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6. Effects of Transcranial Direct Current Stimulation on Clinical Features of Dizziness and Cortical Activation in a Patient with Vestibular Migraine.

Author

Yeo, Sang Seok, Kim, Chang Ju, Yun, Seong Ho, Son, Sung Min, and Kim, Yoon Jae

Subjects
*TRANSCRANIAL direct current stimulation, *VERTIGO, *TEMPORAL lobe, *DIZZINESS, *NEAR infrared spectroscopy, *MIGRAINE
Abstract

Background: Vestibular migraine (VM) is common migraine that occurs in patients with dizziness. Vestibular rehabilitation for managing VM generally remains unclear. Recently, it has been reported that transcranial direct current stimulation (tDCS) has positive effects in alleviating dizziness. This study investigated the effects of tDCS on dizziness and cortical activation in a patient with VM. Methods: We recruited a male patient aged 31 years with no dizziness. The patient watched a video to induce dizziness using a virtual reality device. The study applied the intervention using tDCS for 4 weeks and measured 4 assessments: functional near-infrared spectroscopy (fNIRS), quantitative electroencephalography (qEEG), dizziness handicap inventory, and visual vertigo analog scale. Results: We showed the activation in the middle temporal gyrus and inferior temporal gyrus (ITG) of the left hemisphere and in the superior temporal gyrus and ITG of the right hemisphere in the pre-intervention. After the intervention, the activation of these areas decreased. In the results of qEEG, excessive activation of C3, P3, and T5 in the left hemisphere and C4 in the right hemisphere before intervention disappeared after the intervention. Conclusions: This study indicated that tDCS-based intervention could be considered a viable approach to treating patients with vestibular dysfunction and dizziness caused by VM. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Antifatigue Potential of Loquat Leaf Extract in Physical Stress in C2C12 Myotubes and In Vivo Models.

Author

Kim, Hee-Yun, Kang, Soonsik, Min, Kyunghwon, Kweon, Minson, Kim, Jungeun, Choi, Su-Young, Kim, Chang-Ju, Kim, Hyung-Min, and Jeong, Hyun-Ja

Subjects
LOQUAT, PHYSIOLOGICAL stress, TREADMILL exercise tests, CHLOROGENIC acid, SUPEROXIDE dismutase
Abstract

Recent studies suggest that oxidative stress could be one of the mechanisms contributing to fatigue. The purpose of the present study was to determine the antifatigue potential of loquat leaf (Eriobotrya japonica Lindl., EJ) and its component, chlorogenic acid (CA) in C2C12 myotubes and treadmill stress test (TST), and forced swimming test (FST) in animal models. EJ and CA reduced levels of metabolic factors associated with fatigue and enhanced catalytic properties of superoxide dismutase and catalase in C2C12 myotubes. In the FST and TST, EJ and CA decreased immobility time and prolonged exhaustion time. The administration of EJ and CA reduced the levels of the metabolic factors associated with fatigue and augmented the levels of the substances which relieve fatigue. These results prove that EJ alleviates fatigue by increasing antioxidative activity. Therefore, we suggest that EJ may be a potential candidate for management of fatigue as a health functional food. [ABSTRACT FROM AUTHOR]

Published
2023
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11. Physiotherapy strategies for functional improvement in a child with complicated hereditary spastic paraplegia: 1‐year follow‐up of a case report using a changing criterion design.

Author

Choi, Ji‐Young, Oh, Duck‐Won, Son, Sung‐Min, and Kim, Chang‐Ju

Subjects
HIP joint physiology, PATIENT aftercare, EXERCISE tests, KNEE joint, RANGE of motion of joints, PHYSICAL therapy, FUNCTIONAL status, CARDIOPULMONARY system, GAIT in humans, FAMILIAL spastic paraplegia, TREATMENT effectiveness, SPASTICITY, MUSCLE weakness, LEG, QUALITY assurance, ABDUCTION (Kinesiology), DESCRIPTIVE statistics, DIAGNOSIS, ADDUCTION, DATA analysis software
Abstract

Background: and Purpose: Hereditary spastic paraplegias (HSP) are a group of clinically diverse genetic disorders that share the neurologic symptom of difficulty in walking due to progressive serious muscle weakness and spasticity in the legs. This study describes a physiotherapy program for improving the functional ability of a child diagnosed with complicated HSP and reports the treatment results. Methods: A 10‐year‐old boy with complicated HSP received a physiotherapy intervention that included strengthening of the leg muscles and treadmill training for 1 h per session, three to four times a week for 6 weeks. Outcome measures included sit‐to‐stand, 10‐m walk, 1‐min walk tests, and gross motor function measures (dimensions D and E). Results: After the intervention, the sit‐to‐stand, 1‐min walk, and 10‐m walk test scores improved by 6.75 times, 2.57 m, and 0.05 m/s, respectively. Furthermore, the gross motor function measure dimensions D and E scores improved by 8% (46%–54%) and 5% (22%–27%), respectively. The gains in each parameter were maintained at the 3‐ and 6‐month and 1‐year follow‐ups. Conclusion: These results suggest that structured physiotherapy programs can benefit the functional rehabilitation of children with complicated HSP. [ABSTRACT FROM AUTHOR]

Published
2023
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29. A static model of chip formation in microscale milling

Author

Kim, Chang-Ju, Mayor, J. Rhett, and Ni, Jun

Subjects
Nanotechnology -- Research, Production engineering -- Research, Engineering and manufacturing industries, Science and technology
Abstract

This paper discusses the development of an enhanced, static model of chip formation in micromilling processes that is able to describe the intermittency of the chip formation observed at low feeds per tooth due to the dominance of the minimum chip thickness effect. Experimental analyses demonstrate the validity of the proposed model by verifying the level of periodicity in the cutting forces present at various feeds per tooth. A key finding of this study is the identification of a local maximum in the radial thrust forces in the micromilling process during the noncutting regime, at feeds per tooth that are of the order of the minimum chip thickness. To overcome the challenges in the direct measurement of the minimum chip thickness, this paper presents a method for estimating the minimum chip thickness of various combinations of tools and workpiece materials based on easily attainable cutting-force data. A discussion on the selection of process parameters to avoid intermittent chip formation is also presented. Keywords: Micromilling, Micromanufacturing, Intermittent Chip Formation, Minimum Chip Thickness, Edge-Radius Effect

Published
2004

32. Protective effect of acanthopanax senticosus against ethanol-induced apoptosis of human neuroblastoma cell line SK-N-MC

Author

Jang, Mi-Hyeon, Shin, Min-Chul, Kim, Youn-Jung, Kim, Chang-Ju, Chung, Joo-Ho, Seo, Jung-Chul, Kim, Ee-Hwa, Kim, Kyu-Yeol, Lee, Choong-Yeol, and Kim, Kyeong-Mi

Subjects
Medicinal plants -- Health aspects, Medicinal plants -- Evaluation, Siberian ginseng -- Health aspects, Neuroblastoma -- Care and treatment, Medicine, Chinese -- Research, Medicine, Chinese -- Evaluation, Health
Published
2003

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