38 results on '"Kelly PC"'
Search Results
2. Validation of key indicators in cattle farms at high risk of animal welfare problems: a qualitative case-control study.
- Author
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Kelly PC, More SJ, Blake M, Higgins I, Clegg T, and Hanlon A
- Subjects
- Animals, Case-Control Studies, Cattle, Databases, Factual statistics & numerical data, Female, Ireland, Male, Risk Factors, Animal Husbandry statistics & numerical data, Animal Welfare, Dairying statistics & numerical data
- Abstract
The objective of this study was to validate four key farmer performance indicators (KFPI), identified in a previous study, as indicators of on-farm cattle welfare incidents in Ireland, through comparison of the distribution of these KPFIs in the national herd (n=109,925) and in case herds (n=18), where welfare incidents were previously studied. The KFPIs identified were late registrations, and exits from the herd by on-farm burial, by moves to knackeries and by moves to 'herd unknown'. Data were extracted from two Department of Agriculture, Food and the Marine databases for the national herd and the case herds. All four KFPIs differed significantly between the case herds and the national herd, and one further KFPI was identified, namely moves to factories. The data for these KFPIs are routinely stored on national databases, which were established in order to comply with Regulation (EC) 1760/2000. Based on the results obtained in this study, it may be possible in the future to use routine data capture to improve strategy towards on-farm animal welfare. At this point, however, based on calculated specificities and sensitivities, none of these five KFPIs, at the cut-offs investigated and using several combinations, are able to distinguish herds with and without on-farm animal welfare problems at an accuracy suitable for routine national use in Ireland.
- Published
- 2013
- Full Text
- View/download PDF
3. Identification of key performance indicators for on-farm animal welfare incidents: possible tools for early warning and prevention.
- Author
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Kelly PC, More SJ, Blake M, and Hanlon AJ
- Abstract
Background: The objective of this study was to describe aspects of case study herds investigated by the Department of Agriculture, Fisheries and Food (DAFF) in which animal welfare incidents occurred and to identify key performance indicators (KPIs) that can be monitored to enhance the Early Warning System (EWS). Despite an EWS being in place for a number of years, animal welfare incidents continue to occur. Questionnaires regarding welfare incidents were sent to Superintending Veterinary Inspectors (SVIs), resulting in 18 herds being chosen as case study herds, 12 of which had a clearly defined welfare incident date. For each study herd, data on six potential KPIs were extracted from DAFF databases. The KPIs for those herds with a clearly defined welfare incident date were studied for a consecutive four year window, with the fourth year being the 'incident year', when the welfare incident was disclosed. For study herds without a clearly defined welfare incident date, the KPIs were determined on a yearly basis between 2001 and 2009., Results: We found that the late registration of calves, the use of on-farm burial as a method of carcase disposal, an increasing number of moves to knackeries over time and records of animals moved to 'herd unknown' were notable on the case farms., Conclusion: Four KPIs were prominent on the case study farms and warrant further investigation in control herds to determine their potential to provide a framework for refining current systems of early warning and prevention.
- Published
- 2011
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4. Medical equipment use in children with disabilities: A descriptive survey.
- Author
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Peredo DE, Davis BE, Norvell DC, and Kelly PC
- Abstract
Objective: To investigate the use of medical equipment by children with disabilities, the reasons for use, and prescribers of equipment., Methods: A convenience sample., Setting: Referral clinic for children with developmental conditions., Participants: Caregivers of children with motor disabilities completed an interview survey for children 0-21 years., Results: 108 parents/caregivers reported 467 (mean=4.3 per patient) pieces of owned equipment. The mean age of children was 7.1 years (± 5.0), and 49% were female. The most common diagnoses were cerebral palsy (45%), 'Other' diagnoses including intellectual disability (19%), genetic abnormality (13%), spina bifida (13%), and neuromuscular diseases (7%). Survey participants described use of the following types of equipment: orthotics (82%), bath chair (37%), seating device (34%), stander (19%), augmentative communication devices (17%), walker (14%), and gait trainer (10%). Reasons for "non-use" of equipment included: outgrown (19%), not useful (14%), and child refusal (15%). Physicians were the sole prescriber for 15% of families, whereas physical or occupational therapists most commonly recommended new equipment (76%)., Conclusion: Based on parental report, children with neuromuscular disabilities use most equipment that is medically recommended. The majority of equipment needs are identified by therapists. Pediatricians can benefit from additional expertise in the provision of medical equipment for children.
- Published
- 2010
- Full Text
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5. Public health surveillance for coccidioidomycosis in Arizona.
- Author
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Sunenshine RH, Anderson S, Erhart L, Vossbrink A, Kelly PC, Engelthaler D, and Komatsu K
- Subjects
- Arizona, Communicable Disease Control, Demography, Disease Notification, Disease Outbreaks, Humans, Incidence, Lung Diseases, Fungal epidemiology, Models, Statistical, Population Surveillance, Public Health, Seasons, Time Factors, Coccidioidomycosis diagnosis, Coccidioidomycosis epidemiology, Lung Diseases, Fungal microbiology
- Abstract
Coccidioidomycosis or Valley Fever is a fungal disease that occurs primarily in the southwestern United States. Of the estimated 150,000 U. S. coccidioidomycosis infections per year, approximately 60% occur in Arizona, making this state the focal point for investigation of the disease. In this manuscript, we describe the epidemiology of coccidioidomycosis reported in Arizona over the last decade, hypotheses for the findings, and Arizona's response to the rising epidemic. Coccidioidomycosis surveillance data in Arizona consist of basic demographics of all laboratory and physician-diagnosed cases, the reporting of which has been mandated by law since 1997. The rate of reported coccidioidomycosis has more than quadrupled over the last decade from 21 cases per 100,000 population in 1997 to 91 cases per 100,000 in 2006 (P < 0.001). Case rates in older age groups (>/=65 years old) have more than doubled since 2000 (P < 0.001). These data demonstrate the rising coccidioidomycosis epidemic in Arizona, especially among the elderly. The increase in the numbers of reported cases can be partially explained by the institution of mandatory laboratory reporting in 1997, but the cause of the persistent rise after 1999 is unknown. Further investigation of coccidioidomycosis will not only assist with the development of public health interventions to control this disease in Arizona and the southwestern United States, but will also provide important information to prepare for a bioterrorism event caused by this select agent.
- Published
- 2007
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6. Ghrelin levels in young children with Prader-Willi syndrome.
- Author
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Erdie-Lalena CR, Holm VA, Kelly PC, Frayo RS, and Cummings DE
- Subjects
- Body Mass Index, Child, Preschool, Chromatography, High Pressure Liquid, Female, Ghrelin, Humans, Male, Radioimmunoassay, Peptide Hormones blood, Prader-Willi Syndrome blood
- Abstract
Objective: To explore the hypothesis that high ghrelin levels contribute to obesity in Prader-Willi syndrome (PWS), we assessed whether the increased levels observed in older persons with PWS exist in very young children, before the onset of hyperphagia., Study Design: We measured ghrelin levels in nine children with PWS (17-60 months of age) and eight healthy control subjects of equivalent body mass index (BMI), age, and sex., Results: PWS and control groups had equivalent BMI (16.8 +/- 1.4 vs 16.1 +/- 0.9 kg/m(2), respectively; P = .24), age (37.8 +/- 15.4 vs 50.3 +/- 17.7 months; P = .14), and sex. PWS and control groups also had equivalent fasting levels of total ghrelin (787 +/- 242 vs 716 +/- 135 pg/mL, respectively; P = .24), bioactive ghrelin (102 +/- 35 vs 91 +/- 23 pg/mL; P = .45), insulin, and glucose. Ghrelin correlated negatively with BMI among controls (r = -0.760, P = .029) but not PWS (r = 0.015, P = .97)., Conclusions: Children <5 years of age with PWS, who had not yet developed hyperphagia or excessive obesity, had normal ghrelin levels, in contrast with the hyperghrelinemia of older, hyperphagic people with PWS. It is possible that ghrelin levels increase suddenly before hyperphagia develops.
- Published
- 2006
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7. Mentoring for the New Millennium.
- Author
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Walker WO, Kelly PC, and Hume RF Jr
- Abstract
The challenges and benefits of a formal mentoring program are considered within the context of learning organizations: specifically, graduate medical education and professional development. While no single definition addresses every aspect of mentoring, this process is a distinct one with established traditions and expectations. The core requirements of attraction, action and affect remain and are essential for this adult developmental process to be successful. This paper's review of the literature supports the belief that mentoring has value, even into the next millennium, with some conceptual evolution. We are encouraging a paradigm shift from the traditional dyad model of mentoring to a triad model: organization, mentor, and protégé. The future development of outcome measures will be a necessary goal to demonstrate that both personal and organizational goals can coexist.
- Published
- 2002
- Full Text
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8. Coccidioidomycosis in patients infected with human immunodeficiency virus: review of 91 cases at a single institution.
- Author
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Singh VR, Smith DK, Lawerence J, Kelly PC, Thomas AR, Spitz B, and Sarosi GA
- Subjects
- Adult, Antifungal Agents therapeutic use, CD4 Lymphocyte Count, Female, Humans, Logistic Models, Male, Retrospective Studies, Survival Rate, AIDS-Related Opportunistic Infections diagnosis, AIDS-Related Opportunistic Infections drug therapy, AIDS-Related Opportunistic Infections mortality, AIDS-Related Opportunistic Infections physiopathology, Coccidioidomycosis diagnosis, Coccidioidomycosis drug therapy, Coccidioidomycosis mortality, Coccidioidomycosis physiopathology
- Abstract
We retrospectively evaluated the clinical manifestations, diagnosis, treatment, and outcome of coccidioidomycosis in 91 patients infected with human immunodeficiency virus (HIV) at a single institution. Coccidioidomycosis was the AIDS-defining illness in 37 patients. Fever and chills, weight loss, and night sweats were the most frequent symptoms. The lung was the most frequently involved organ (80%), followed by the meninges (15%). A diffuse reticulonodular infiltrate was seen in 59 patients (65%), and 13 (14%) had focal pulmonary disease; for 15 patients (16%), the chest radiograph was normal. Coccidioidal serologies were positive for 60 patients (68%), while for 23% with proven coccidioidomycosis such tests were negative Most patients were treated with systemic amphotericin B and then an oral azole. The mortality for the whole group was 60%. Patients with diffuse pulmonary disease had the highest mortality (68%), with a median duration of survival of 54 days (P < .05; 95% confidence interval, 147-175 days). The presence of diffuse pulmonary disease and a CD4 lymphocyte count of < 50/microL were independent predictors of death. In our experience, coccidioidomycosis is an important opportunistic infection that causes substantial morbidity and mortality among HIV-infected patients living in an area of endemicity.
- Published
- 1996
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9. Lead screening in children with attention deficit hyperactivity disorder and developmental delay.
- Author
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Kahn CA, Kelly PC, and Walker WO Jr
- Subjects
- Attention Deficit Disorder with Hyperactivity blood, Attention Deficit Disorder with Hyperactivity diagnosis, Child, Child, Preschool, Demography, Developmental Disabilities blood, Developmental Disabilities diagnosis, Environmental Exposure, Female, Health Surveys, Humans, Infant, Lead blood, Lead Poisoning blood, Lead Poisoning diagnosis, Lead Poisoning epidemiology, Male, Mass Screening, Surveys and Questionnaires, Washington epidemiology, Attention Deficit Disorder with Hyperactivity chemically induced, Developmental Disabilities chemically induced, Lead Poisoning complications
- Published
- 1995
- Full Text
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10. Progression of tympanometry and acoustic reflectometry. Findings in children with acute otitis media.
- Author
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Babonis T, Weir MR, Kelly PC, and Krober MS
- Subjects
- Acute Disease, Adolescent, Adult, Amoxicillin administration & dosage, Amoxicillin therapeutic use, Child, Child, Preschool, Cost-Benefit Analysis, Exudates and Transudates, Follow-Up Studies, Humans, Infant, Otitis Media drug therapy, Otitis Media physiopathology, Otolaryngology instrumentation, Pressure, Prognosis, Tympanic Membrane physiopathology, Acoustic Impedance Tests economics, Acoustic Impedance Tests instrumentation, Otitis Media diagnosis, Reflex, Acoustic physiology
- Abstract
The presence of middle ear effusion (MEE) following acute otitis media (AOM) has been assessed by impedance tympanometry and acoustic reflectometry but has not been assessed serially from the time of presentation for AOM in the same group of patients. This descriptive study examined serial measurements by tympanometry and reflectometry in children with clinical AOM at the time of diagnosis, 3 to 5 days later, and at final follow-up 12 to 15 days after diagnosis. The study entry criteria were conservative in order to represent obvious cases of AOM and included 90 patients representing 107 ears. The objective was to describe the evolution of instrumental findings and to attempt to identify unique patient subpopulations with differing prognoses. We found that combined use of initial tympanometry and reflectometry, while yielding intriguing results, does not allow for identification of subpopulations with good or poor progression for MEE clearance at 2-week follow-up. It is our conclusion that initial tympanometry and reflectometry add to the cost of AOM diagnosis without clear benefit for the individual patient.
- Published
- 1994
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11. Coccidioidomycosis and pregnancy.
- Author
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Peterson CM, Schuppert K, Kelly PC, and Pappagianis D
- Subjects
- Adult, Amphotericin B administration & dosage, Coccidioidomycosis drug therapy, Diabetes Mellitus, Type 1 drug therapy, Erythema Multiforme diagnosis, Erythema Multiforme drug therapy, Erythema Nodosum diagnosis, Erythema Nodosum drug therapy, Female, Fetal Death, Humans, Insulin Infusion Systems, Opportunistic Infections drug therapy, Pregnancy, Pregnancy Complications, Infectious drug therapy, Pregnancy Trimester, Second, Pregnancy in Diabetics drug therapy, Coccidioidomycosis diagnosis, Diabetes Mellitus, Type 1 diagnosis, Opportunistic Infections diagnosis, Pregnancy Complications, Infectious diagnosis, Pregnancy in Diabetics diagnosis
- Abstract
Pregnant women with respiratory symptoms of pleuritic pain and productive cough should undergo evaluation for coccidioidomycosis. This should include a history of travel or residency in endemic areas and careful assessment for toxic erythema, erythema nodosum, or erythema multiforme. To confirm a diagnosis of this disease, a sputum culture, wet mount, and serological tests should be performed. The risk of dissemination, which is highest in the second and third trimesters, can be estimated by a complement-fixation titer. In disseminated cases aggressive treatment with amphotericin B has improved the previously reported high maternal and neonatal mortality rate. Fortunately, case reports do not indicate that transplacental spread occurs. Reactivation or exacerbation of a chronic low-grade infection during pregnancy may occur in patients treated for prior disseminated disease (32, 34). Interestingly, both of the reported cases of reactivation or exacerbation occurred in insulin-dependent diabetics.
- Published
- 1993
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12. Impedance tympanometry and acoustic reflectometry at myringotomy.
- Author
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Babonis TR, Weir MR, and Kelly PC
- Subjects
- Acoustic Impedance Tests methods, Child, Child, Preschool, Female, Humans, Infant, Male, Otitis Media with Effusion surgery, Recurrence, Sensitivity and Specificity, Tympanic Membrane surgery, Acoustic Impedance Tests instrumentation, Otitis Media with Effusion diagnosis, Tympanic Membrane physiology
- Abstract
A total of 220 ears undergoing myringotomy and pressure-equalizing tube placement were studied with impedance tympanometry and acoustic reflectometry in a direct comparison for detection of middle-ear effusion. Impedance tympanometry and acoustic reflectometry were equally accurate, detecting the presence or absence of middle-ear effusion in 73% and 72% of ears, respectively. The presence of effusion in ears with tympanographic patterns other than type A and type B was not consistently and reliably predicted. The higher sensitivity of impedance tympanometry (90%) compared with that for acoustic reflectometry (58%) contrasted with the opposite findings for specificities (54% vs 88%). It is concluded that impedance tympanometry and acoustic reflectometry measure different events at the tympanic membrane and their utility lies in the fact that they complement each other. These instruments can aid the experienced otoscopist in confirming a clinical impression and assist the less experienced clinician in validating or improving otoscopic skills.
- Published
- 1991
13. Coccidioidomycosis during human immunodeficiency virus infection. A review of 77 patients.
- Author
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Fish DG, Ampel NM, Galgiani JN, Dols CL, Kelly PC, Johnson CH, Pappagianis D, Edwards JE, Wasserman RB, and Clark RJ
- Subjects
- Adult, Amphotericin B therapeutic use, Arizona, California, Coccidioidomycosis blood, Coccidioidomycosis drug therapy, Dermatomycoses complications, Female, Follow-Up Studies, HIV Infections blood, Humans, Ketoconazole therapeutic use, Leukocyte Count, Liver Diseases complications, Lung Diseases, Fungal complications, Lymphatic Diseases complications, Male, Meningitis complications, Retrospective Studies, T-Lymphocytes, Helper-Inducer pathology, Coccidioidomycosis complications, HIV Infections complications
- Abstract
Through a retrospective review, we identified 77 previously unreported cases of coccidioidomycosis during HIV infection. Patients were classified into 1 of 6 categories based on their primary clinical presentation: 20 had focal pulmonary disease (Group 1), 31 had diffuse pulmonary disease (Group 2), 4 had cutaneous coccidioidomycosis (Group 3), 9 had meningitis (Group 4), 7 had extrathoracic lymph node or liver involvement (Group 5), and 6 has positive coccidioidal serology without a clinical focus of infection (Group 6). Coccidioidal serologies were positive on initial testing in 83% of the patients in whom such serologic testing was performed. Sera from 39% of patients were positive for TP antibodies while 74% had CF antibodies. Eleven of 12 seronegative patients had pulmonary disease (Group 1 or 2). Serologic results of other patients sent to a single reference laboratory were similar, with 26% positive for immunodiffusion TP antibodies and 79% positive for immunodiffusion CF antibodies. For the 77 patients in this study, the CD4-lymphocyte count was below 0.250 X 10(9) cells/L in 46 of the 55 patients who had this test performed, and a low CD4 count was significantly associated with mortality (p less than 0.01). At the time of follow-up, 32 of the 77 patients (42%) had died. There were significantly more deaths in those with diffuse pulmonary disease (Group 2) than in other groups (p less than 0.001). Amphotericin B, ketoconazole, fluconazole, and itraconazole were all used as antifungal therapies. Outcome could not be related to the therapy used. Of note, 3 patients developed coccidioidomycosis while receiving ketoconazole for other conditions.(ABSTRACT TRUNCATED AT 250 WORDS)
- Published
- 1990
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14. Outlier detection in collaborative studies.
- Author
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Kelly PC
- Subjects
- Animals, Meat analysis, Nitrites analysis, Reference Standards, Research Design, Statistics as Topic, Food Analysis
- Abstract
Extended tables of critical values for the reduction in standard deviation tests for single and paired outliers recommended for collaborative studies are presented. Critical values for the single outlier test are derived mathematically and those for the paired test are derived from computer simulations. The single outlier test becomes more and more stringent as the size of the study increases. A confidence interval approach is suggested as a means to treat all sizes of collaborative studies in a uniform manner.
- Published
- 1990
15. Rabies--a brief review of current management.
- Author
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Kelly PC
- Subjects
- Animals, Arizona, Bites and Stings complications, Brain microbiology, Dogs, Fluorescent Antibody Technique, Immune Sera administration & dosage, Rabies diagnosis, Rabies epidemiology, Rabies prevention & control, Rabies veterinary, Rabies Vaccines administration & dosage, Rabies virus isolation & purification, Species Specificity, Staining and Labeling, Rabies therapy
- Published
- 1974
16. Histoplasmin-CYL, a yeast phase reagent in skin test studies with humans.
- Author
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Levine HB, Scalarone GM, Campbell GD, Graybill JR, Kelly PC, and Chaparas SD
- Subjects
- Antibodies, Fungal analysis, Coccidioides immunology, Coccidioidomycosis immunology, Complement Fixation Tests, Histoplasmosis immunology, Humans, Hypersensitivity, Delayed, Histoplasmin immunology, Skin Tests
- Abstract
A yeast phase histoplasmin, designated CYL, was studied in 156 humans living in areas of the United States endemic for histoplasmosis, coccidioidomycosis, or both fungal entities. Comparisons were made with Food and Drug Administration reference mycelial histoplasmin. Among persons without concurrent spherulin sensitivity, reactor rates and sizes were the same with both reagents. Some persons with spherulin sensitivity reacted only to the mycelial reagent. Histoplasmin-CYL skin tests did not induce significant changes in complement-fixing antibody in histoplasmin-reactive subjects.
- Published
- 1979
- Full Text
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17. Direct determination of tobramycin clearance in patients with mild-to-moderate cystic fibrosis.
- Author
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Kildoo CW, Harralson AF, Folli HL, Kelly PC, and Nussbaum E
- Subjects
- Adolescent, Child, Child, Preschool, Female, Humans, Kinetics, Male, Tobramycin blood, Tobramycin urine, Cystic Fibrosis metabolism, Tobramycin metabolism
- Abstract
Studies performed in patients with cystic fibrosis (CF) have suggested altered pharmacokinetic parameters for aminoglycosides. Specifically, increased plasma clearance (Cl) of aminoglycosides and increased apparent volume of distribution have been noted. In the present study, tobramycin Cl is determined by both serum concentration data and direct renal clearance (Clren). Tobramycin Clren appeared to be directly correlated to the measured creatinine clearance (Clcr) (r = 0.93, p less than 0.01). The tobramycin Cl, by both methods of determination, was not elevated in comparison to the Clcr or expected values for patients without the disease. These results appear to corroborate a recent study in which the renal and plasma Cl of gentamicin was measured in patients with mild-to-moderate CF and were not noted to be elevated. It is suggested that standard doses of tobramycin be used initially in patients with mild-to-moderate CF with dosage adjustment based on serum concentration data to achieve the desired goals.
- Published
- 1987
- Full Text
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18. Rapid identification of material colonization with group B streptococci by use of fluorescent antibody.
- Author
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Boyer KM, Gadzala CA, Kelly PC, Burd LC, and Gotoff SP
- Subjects
- Female, Fluorescent Antibody Technique, Humans, Infant, Newborn, Infant, Newborn, Diseases diagnosis, Labor, Obstetric, Pregnancy, Streptococcal Infections microbiology, Streptococcal Infections transmission, Vagina microbiology, Pregnancy Complications, Infectious diagnosis, Streptococcal Infections diagnosis, Streptococcus agalactiae growth & development
- Abstract
To identify women colonized with group B streptococci during parturition, we used pooled type-specific fluorescent antibody to examine vaginal swabs enriched by preincubation in selective broth medium. In preliminary experiments, group B streptococcus strain III-Bell was reliably detectable with fluorescent antibody at concentrations of greater than 10(5) colony-forming units per ml, achieved after 6 h of incubation of small inocula (18 to 26 colony-forming units). Of the vaginal swabs from 924 parturient women examined prospectively by both fluorescent antibody and selective bacteriology techniques, group B streptococci were isolated in 154. The sensitivity of the fluorescent antibody technique increased with increasing incubation time and ranged from 49% (3 to 6 h) to 81% (7 to 12 h) to 83% (13 to 18 h) to 93% (greater than 18 h). Colonized mothers identified within 6 h by the fluorescent antibody technique had higher rates of vertical transmission to their newborn infants (61%) than colonized mothers whose fluorescent antibody examinations were negative within this time interval (32%; P = 0.027). However, because of the timing of their admissions, none of the colonized mothers of the four infants who developed early-onset group B streptococcal sepsis were identified with fluorescent antibody until after delivery. Although its sensitivity approaches selective culture methods after 6 h of incubation, fluorescent antibody examination of vaginal swabs does not appear to offer a practical approach to identifying colonized parturient women for intrapartum antibiotic prophylaxis of group B streptococcal infection.
- Published
- 1981
- Full Text
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19. Enterohepatic fistula associated with amebic liver abscess.
- Author
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Loprinzi C, Heaton JW Jr, and Kelly PC
- Subjects
- Adult, Aged, Biopsy, Needle, Entamoeba histolytica isolation & purification, Entamoebiasis complications, Female, Fistula diagnostic imaging, Humans, Intestinal Fistula diagnostic imaging, Liver Abscess, Amebic diagnostic imaging, Liver Abscess, Amebic therapy, Liver Diseases diagnostic imaging, Male, Metronidazole therapeutic use, Middle Aged, Radiography, Streptococcal Infections complications, Streptococcus isolation & purification, Ultrasonography, Fistula etiology, Intestinal Fistula etiology, Liver Abscess, Amebic complications, Liver Diseases etiology
- Published
- 1983
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20. Facility for small volume parenteral manufacturing.
- Author
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Kelly PC
- Subjects
- Drug Compounding, Health Facilities, Ventilation, Water Supply, Infusions, Parenteral
- Published
- 1976
21. Ring calcification of coronary artery aneurysms.
- Author
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Pearl WR, Kelly PC, and Weir MR
- Subjects
- Child, Humans, Male, Polyarteritis Nodosa complications, Calcinosis diagnostic imaging, Coronary Aneurysm diagnostic imaging, Coronary Angiography
- Published
- 1988
- Full Text
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22. Evidence for antigenic differences among pyocins of Pseudomonas aeruginosa.
- Author
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Allen JC and Kelly PC
- Subjects
- Animals, Epitopes, Humans, Immune Sera, Pseudomonas aeruginosa analysis, Rabbits immunology, Antigens, Bacterial, Bacteriocins immunology, Pyocins immunology
- Published
- 1975
23. Parent, teacher, child. A trilateral approach to attention deficit disorder.
- Author
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Cohen ML, Kelly PC, and Atkinson AW
- Subjects
- Attention Deficit Disorder with Hyperactivity drug therapy, Child Behavior, Female, Humans, Male, Methylphenidate therapeutic use, Neuropsychological Tests, Parents, Schools, Surveys and Questionnaires, Attention Deficit Disorder with Hyperactivity diagnosis
- Abstract
We compared the effectiveness of three instruments in initially diagnosing and monitoring children with attention-deficit disorder with and without hyperactivity (ADD/H). Twenty-one children clinically assessed as having ADD/H and meeting criteria of the Diagnostic and Statistical Manual of Mental Disorders, Third Edition, were examined initially and after treatment with methylphenidate hydrochloride and placebo. The following instruments were used: the ADD-H Comprehensive Teacher Rating Scale, the Connors' Parent Rating Scale-Revised, and the Gordon Diagnostic System. The ADD-H Comprehensive Teacher Rating Scale initially classified 67% of the children as having ADD/H and 14% as borderline. The Connors' Parent Rating Scale-Revised identified 71% as having ADD/H, while the Gordon Diagnostic System assessed 52% as having ADD/H and 29% as borderline. With methylphenidate treatment, the mean scores on the ADD-H Comprehensive Teacher Rating Scale displayed an increase in attention span and a decrease in hyperactivity, the Connors' Parent Rating Scale-Revised showed a significant decrease in ADD/H behavior, and the Gordon Diagnostic System mean scores indicated no significant change.
- Published
- 1989
24. Self-esteem in children medically managed for attention deficit disorder.
- Author
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Kelly PC, Cohen ML, Walker WO, Caskey OL, and Atkinson AW
- Subjects
- Attention Deficit Disorder with Hyperactivity psychology, Attention Deficit Disorder with Hyperactivity therapy, Child, Child Behavior, Double-Blind Method, Female, Follow-Up Studies, Humans, Male, Parents, Personality Inventory, Placebos, Teaching, Attention Deficit Disorder with Hyperactivity drug therapy, Methylphenidate therapeutic use, Self Concept
- Abstract
Self-esteem was measured initially in a group of 21 eight- to 12-year-old children with newly diagnosed attention deficit disorder/hyperactivity and remeasured after 1-month courses of treatment with methylphenidate and placebo given in double-blind crossover fashion. Multimodal management of all patients included diagnosis, demystification, medication, close follow-up with supportive counseling, and referral as indicated for psychosocial and educational assistance. Long-term follow-up of 12 children who continued to receive methylphenidate was done for an average of 16 months. Initial total self-esteem was low in 30% of all subjects, intermediate in 55%, and high in 15%. No statistically significant changes occurred in self-esteem during the short-term phase of the study despite clinically significant behavioral responses to medication as assessed by serial questionnaires. At long-term follow-up, total, general, and academic self-esteem scores were improved significantly, however. These findings indicate that many preadolescents with attention deficit disorder/hyperactivity exhibit low self-esteem. Despite clinical response to medication, short-term improvement in self-esteem may not occur; however, long-term, multimodal management that includes medication does appear to improve self-esteem.
- Published
- 1989
25. A survey of parental opinions on corporal punishment in schools.
- Author
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Kelly PC, Weir MR, and Fearnow RG
- Subjects
- Achievement, Adult, Child, Child Behavior, Female, Humans, Male, Attitude, Parents psychology, Punishment, Schools
- Abstract
Forty-three states permit corporal punishment in schools. This practice continues despite the universal opposition of professional organizations, including the American Academy of Pediatrics. This study determines parental attitudes concerning the use of physical punishment in schools. The surveyed sample is drawn from parents of military dependents who brought their children to this clinic for routine physical examinations. One hundred and twenty-nine of 132 questionnaires were returned for a 98% response rate. Fifty-one percent of the parents supported the use of corporal punishment in schools, 37% disagreed (77% of these strongly), 11% had no opinion, and 1% did not respond to the question. Analysis of the responses displayed a relationship between parental attitudes on the use of corporal punishment and opinion of the positive effects of physical punishment on children's behavior (p less than 0.0001). No relationship was found between position on corporal punishment and the respondent (mother, father, or both), the age of parents, the military rank of the sponsor (the individual whose military service makes the child eligible for military medical care, i.e., father, mother, guardian, etc.), the sex of the children, the marital status of the parents, or the schools attended by the children (public or private). Thirty-four percent of parents believed corporal punishment would improve behavior, and 20% of parents felt that physical punishment would improve their child's academic performance.
- Published
- 1985
26. Antigenic heterogeneity among pyocins of Pseudomonas aeruginosa.
- Author
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Allen JC and Kelly PC
- Subjects
- Absorption, Animals, Antigens, Bacterial, Female, Immune Sera, Male, Pseudomonas Infections immunology, Pseudomonas aeruginosa growth & development, Pseudomonas aeruginosa metabolism, Pyocins metabolism, Rabbits immunology, Serotyping, Structure-Activity Relationship, Bacteriocins immunology, Epitopes, Pseudomonas aeruginosa immunology, Pyocins immunology
- Abstract
We investigated the effect of FeSO4 on phagocytosis-associated, increased oxidative metabolism via the hexose monophosphate shunt, with special attention to its effect on H2O2 levels. The availability of glutathione peroxidase and glutathione reductase for H2O2 disposal and hexose monophosphate shunt stimulation also are evaluated. The results show an impairment of phagocytosis-associated hexose monophosphate shunt activity together with an increase both of resting and phagocytosing formate oxidation. These apparently paradoxical findings are resolved by demonstrating a direct enhancement of formate oxidation by FeSO4 in a cell-free system. In addition, measurement of H2O2 concentrations via scopoletin fluorescence shows reduction of H2O2 by FeSO4. There is no effect on either glutathione peroxidase or glutathione reductase activities. These data suggest that one mechanism of FeSO4 impairment of microbicidal activity is by its removal of H2O2.
- Published
- 1975
- Full Text
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27. Pediatricians' views: "latchkey" children, corporal punishment.
- Author
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Kelly PC, Weir MR, and Fearnow RG
- Subjects
- Child, Humans, Texas, Attitude of Health Personnel, Child Abuse prevention & control, Child Rearing, Punishment
- Published
- 1987
28. Coccidiodal meningitis and pregnancy: a case report.
- Author
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Peterson CM, Johnson SL, Kelly JV, and Kelly PC
- Subjects
- Adult, Amphotericin B administration & dosage, Amphotericin B therapeutic use, Coccidioides isolation & purification, Drug Administration Schedule, Female, Humans, Injections, Intravenous, Injections, Spinal, Pregnancy, Recurrence, Coccidioidomycosis cerebrospinal fluid, Coccidioidomycosis drug therapy, Meningitis cerebrospinal fluid, Meningitis drug therapy, Pregnancy Complications, Infectious cerebrospinal fluid, Pregnancy Complications, Infectious drug therapy
- Abstract
A woman with coccidiodal meningitis had two successive pregnancies and was treated with intrathecal amphotericin B. The outcome was successful.
- Published
- 1989
29. Serious infection as a complication of arterial catheterization.
- Author
-
Kelly PC and Cackler CS
- Subjects
- Blood Pressure, Female, Humans, Middle Aged, Time Factors, Bacterial Infections etiology, Catheterization adverse effects
- Published
- 1976
30. Tonsillar hemorrhage. Unusual complication of infectious mononucleosis.
- Author
-
Kelly PC and Sanders M
- Subjects
- Adult, Female, Humans, Hemorrhage etiology, Infectious Mononucleosis complications, Palatine Tonsil
- Published
- 1974
31. Spherulin skin testing and histoplasmal and coccidioidal serology: lack of effect.
- Author
-
Deresinski SC, Levine HB, Kelly PC, Creasman RJ, and Stevens DA
- Subjects
- Antibodies, Fungal isolation & purification, Coccidioidomycosis diagnosis, Coccidioidomycosis immunology, Complement Fixation Tests, Histoplasmosis diagnosis, Histoplasmosis immunology, Humans, Antigens, Fungal administration & dosage, Coccidioides immunology, Histoplasma immunology, Skin Tests methods
- Abstract
This study demonstrated that the administration of a spherulin skin test to subjects whose skin-test reactions were either positive or negative, at the dose used (Usual Test Strength), did not elicit an antibody response to antigens of Coccidioides immitis or Histoplasma capsulatum, as determined by standard serologic methods. Of 32 subjects, one developed a seroconversion by the latex agglutination test. The data suggested that spherulin can be used clinically as a diagnostic reagent without affecting the serologic reactions, which are of both prognostic and diagnostic value.
- Published
- 1977
- Full Text
- View/download PDF
32. Infantile polyarteritis nodosa with mucocutaneous lymph node syndrome treated with long-term corticosteroids.
- Author
-
Kelly PC, Pearl WR, and Weir MR
- Subjects
- Aneurysm drug therapy, Brachial Artery, Child, Coronary Aneurysm drug therapy, Femoral Artery, Humans, Infant, Long-Term Care, Male, Mucocutaneous Lymph Node Syndrome diagnosis, Polyarteritis Nodosa diagnosis, Mucocutaneous Lymph Node Syndrome drug therapy, Polyarteritis Nodosa drug therapy, Prednisone therapeutic use
- Abstract
Clinical and pathologic similarities between infantile polyarteritis nodosa (IPN) and mucocutaneous lymph node syndrome (MLNS, or Kawasaki disease) have suggested that these entities may be different manifestations of the same basic disease process. We have described a boy with IPN/MLNS treated with long-term corticosteroids for more than eight years after the appearance of multiple aneurysms at 11 months of age. Corticosteroid therapy may be appropriate in the treatment of selected patients with IPN/MLNS if based on age and the presence of aneurysms.
- Published
- 1987
- Full Text
- View/download PDF
33. Liposarcoma of the foot: a case report.
- Author
-
Kelly PC and Shramowiat M
- Subjects
- Female, Foot Diseases pathology, Humans, Liposarcoma pathology, Middle Aged, Foot Diseases surgery, Liposarcoma surgery
- Abstract
A 56-year-old black, apparently healthy female presented with a rapidly growing mass on the medial aspect of her left hallux. The mass was seen on x-ray examination, and did not appear locally invasive. Excision revealed the mass to be a well differentiated liposarcoma, and after further consultation, the left hallux was amputated. Although the incidence of differentiated liposarcoma in the foot is rare, the preceding case should reiterate to all the need for closer investigation of soft tissue masses which may appear in the foot. Prompt excision of malignant tumors results in a good prognosis for the patients, whereas misdiagnosis based on the apparently benign appearance may lead to unnecessary delay and a less fortuitous prognosis for the patient.
- Published
- 1978
34. Tandem Y/6 translocation with partial deletion 6 (p23----pter).
- Author
-
Kelly PC, Blake WW, and Davis JR
- Subjects
- Abnormalities, Multiple surgery, Humans, Infant, Karyotyping, Male, Sex Chromosome Aberrations genetics, Abnormalities, Multiple genetics, Chromosome Deletion, Chromosomes, Human, Pair 6, Translocation, Genetic, Y Chromosome
- Abstract
An infant with multiple malformations had a de novo tandem translocation of the Y chromosome to chromosome 6. The karyotype 45,X,tan(Y;6) (q12;p23) resulted in a partial monosomy of 6p23----pter. Many of the effects of ring chromosome 6 are present in this case.
- Published
- 1989
35. Unsupervised children in motor vehicles.
- Author
-
Kelly PC, Weir MR, and Atkinson AW
- Subjects
- Adolescent, Child, Child, Preschool, Humans, Infant, Military Personnel, Parents, Pediatrics, Surveys and Questionnaires, Accident Prevention, Attitude, Automobiles
- Published
- 1985
- Full Text
- View/download PDF
36. Epidemic hepatitis in a clinical laboratory. Possible association with computer card handling.
- Author
-
Pattison CP, Boyer DM, Maynard JE, and Kelly PC
- Subjects
- Adult, Aged, Aspartate Aminotransferases blood, Blood Banks, Cell Membrane immunology, Computers, Environmental Exposure, Hepatitis B enzymology, Hepatitis B immunology, Hepatitis B Antibodies analysis, Hepatitis B Antigens analysis, Humans, Middle Aged, Occupations, Radioimmunoassay, Skin microbiology, Time Factors, Wounds and Injuries microbiology, Disease Outbreaks, Hepatitis B transmission, Laboratory Infection transmission
- Published
- 1974
37. "Latchkey". Three voices with one message.
- Author
-
Kelly PC, Weir MR, Atkinson AW, Lampe RM, Schydlower M, and Fearnow RG
- Subjects
- Adolescent, Attitude, Child, Humans, Parents, Pediatrics, Child Care, Child Welfare
- Abstract
Two to five million children, 6 through 13 years old, are unsupervised at home after school. This practice, called "latchkey," involves issues of children without adult supervision for periods of time and questions of safety and social isolation. There are no published age guidelines for "latchkey" or data on actual practice. To investigate age guideline opinions and the factors that influence them, a survey of pediatricians (the professional voice), military police (the legal voice), and parents (the popular voice) was undertaken. Solicited opinions concerned ages at which children can be left alone for brief or extended periods and can be allowed to babysit younger children. The three "voices" expressed similar mean ages and distributions for each of the "latchkey" questions. For less than 15 minutes without supervision, the means approximated 9 years; for periods of 1 hour or longer, 12 years; and for babysitting, 14 years. The data presented do not address actual or appropriate practice, but instead provide a basis to begin investigation.
- Published
- 1986
- Full Text
- View/download PDF
38. Studies in kernicterus. II. The determination of the saturation of serum albumin with bilirubin.
- Author
-
Odell GB, Cohen SN, and Kelly PC
- Subjects
- Bilirubin metabolism, Erythroblastosis, Fetal blood, Exchange Transfusion, Whole Blood, Female, Humans, Hydrogen-Ion Concentration, Hyperbilirubinemia blood, Infant, Newborn, Kernicterus metabolism, Mitochondria metabolism, Oleic Acids pharmacology, Pregnancy, Protein Binding, Salicylates pharmacology, Serum Albumin metabolism, Spectrophotometry, Spectrum Analysis, Bilirubin blood, Kernicterus blood, Serum Albumin analysis
- Published
- 1969
- Full Text
- View/download PDF
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