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3. FCC Physics Opportunities

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A. Abada, M. Abbrescia, S. S. AbdusSalam, I. Abdyukhanov, J. Abelleira Fernandez, A. Abramov, M. Aburaia, A. O. Acar, P. R. Adzic, P. Agrawal, J. A. Aguilar-Saavedra, J. J. Aguilera-Verdugo, M. Aiba, I. Aichinger, G. Aielli, A. Akay, A. Akhundov, H. Aksakal, J. L. Albacete, S. Albergo, A. Alekou, M. Aleksa, R. Aleksan, R. M. Alemany Fernandez, Y. Alexahin, R. G. Alía, S. Alioli, N. Alipour Tehrani, B. C. Allanach, P. P. Allport, M. Altınlı, W. Altmannshofer, G. Ambrosio, D. Amorim, O. Amstutz, L. Anderlini, A. Andreazza, M. Andreini, A. Andriatis, C. Andris, A. Andronic, M. Angelucci, F. Antinori, S. A. Antipov, M. Antonelli, M. Antonello, P. Antonioli, S. Antusch, F. Anulli, L. Apolinário, G. Apollinari, A. Apollonio, D. Appelö, R. B. Appleby, Ara. Apyan, Arm. Apyan, A. Arbey, A. Arbuzov, G. Arduini, V. Arı, S. Arias, N. Armesto, R. Arnaldi, S. A. Arsenyev, M. Arzeo, S. Asai, E. Aslanides, R. W. Aßmann, D. Astapovych, M. Atanasov, S. Atieh, D. Attié, B. Auchmann, A. Audurier, S. Aull, S. Aumon, S. Aune, F. Avino, G. Avrillaud, G. Aydın, A. Azatov, G. Azuelos, P. Azzi, O. Azzolini, P. Azzurri, N. Bacchetta, E. Bacchiocchi, H. Bachacou, Y. W. Baek, V. Baglin, Y. Bai, S. Baird, M. J. Baker, M. J. Baldwin, A. H. Ball, A. Ballarino, S. Banerjee, D. P. Barber, D. Barducci, P. Barjhoux, D. Barna, G. G. Barnaföldi, M. J. Barnes, A. Barr, J. Barranco García, J. Barreiro Guimarães da Costa, W. Bartmann, V. Baryshevsky, E. Barzi, S. A. Bass, A. Bastianin, B. Baudouy, F. Bauer, M. Bauer, T. Baumgartner, I. Bautista-Guzmán, C. Bayındır, F. Beaudette, F. Bedeschi, M. Béguin, I. Bellafont, L. Bellagamba, N. Bellegarde, E. Belli, E. Bellingeri, F. Bellini, G. Bellomo, S. Belomestnykh, G. Bencivenni, M. Benedikt, G. Bernardi, J. Bernardi, C. Bernet, J. M. Bernhardt, C. Bernini, C. Berriaud, A. Bertarelli, S. Bertolucci, M. I. Besana, M. Besançon, O. Beznosov, P. Bhat, C. Bhat, M. E. Biagini, J.-L. Biarrotte, A. Bibet Chevalier, E. R. Bielert, M. Biglietti, G. M. Bilei, B. Bilki, C. Biscari, F. Bishara, O. R. Blanco-García, F. R. Blánquez, F. Blekman, A. Blondel, J. Blümlein, T. Boccali, R. Boels, S. A. Bogacz, A. Bogomyagkov, O. Boine-Frankenheim, M. J. Boland, S. Bologna, O. Bolukbasi, M. Bomben, S. Bondarenko, M. Bonvini, E. Boos, B. Bordini, F. Bordry, G. Borghello, L. Borgonovi, S. Borowka, D. Bortoletto, D. Boscherini, M. Boscolo, S. Boselli, R. R. Bosley, F. Bossu, C. Botta, L. Bottura, R. Boughezal, D. Boutin, G. Bovone, I. Božović Jelisavc̆ić, A. Bozbey, C. Bozzi, D. Bozzini, V. Braccini, S. Braibant-Giacomelli, J. Bramante, P. Braun-Munzinger, J. A. Briffa, D. Britzger, S. J. Brodsky, J. J. Brooke, R. Bruce, P. Brückman De Renstrom, E. Bruna, O. Brüning, O. Brunner, K. Brunner, P. Bruzzone, X. Buffat, E. Bulyak, F. Burkart, H. Burkhardt, J.-P. Burnet, F. Butin, D. Buttazzo, A. Butterworth, M. Caccia, Y. Cai, B. Caiffi, V. Cairo, O. Cakir, R. Calaga, S. Calatroni, G. Calderini, G. Calderola, A. Caliskan, D. Calvet, M. Calviani, J. M. Camalich, P. Camarri, M. Campanelli, T. Camporesi, A. C. Canbay, A. Canepa, E. Cantergiani, D. Cantore-Cavalli, M. Capeans, R. Cardarelli, U. Cardella, A. Cardini, C. M. Carloni Calame, F. Carra, S. Carra, A. Carvalho, S. Casalbuoni, J. Casas, M. Cascella, P. Castelnovo, G. Castorina, G. Catalano, V. Cavasinni, E. Cazzato, E. Cennini, A. Cerri, F. Cerutti, J. Cervantes, I. Chaikovska, J. Chakrabortty, M. Chala, M. Chamizo-Llatas, H. Chanal, D. Chanal, S. Chance, A. Chancé, P. Charitos, J. Charles, T. K. Charles, S. Chattopadhyay, R. Chehab, S. V. Chekanov, N. Chen, A. Chernoded, V. Chetvertkova, L. Chevalier, G. Chiarelli, G. Chiarello, M. Chiesa, P. Chiggiato, J. T. Childers, A. Chmielińska, A. Cholakian, P. Chomaz, M. Chorowski, W. Chou, M. Chrzaszcz, E. Chyhyrynets, G. Cibinetto, A. K. Ciftci, R. Ciftci, R. Cimino, M. Ciuchini, P. J. Clark, Y. Coadou, M. Cobal, A. Coccaro, J. Cogan, E. Cogneras, F. Collamati, C. Colldelram, P. Collier, J. Collot, R. Contino, F. Conventi, C. T. A. Cook, L. Cooley, G. Corcella, A. S. Cornell, G. H. Corral, H. Correia-Rodrigues, F. Costanza, P. Costa Pinto, F. Couderc, J. Coupard, N. Craig, I. Crespo Garrido, A. Crivellin, J. F. Croteau, M. Crouch, E. Cruz Alaniz, B. Curé, J. Curti, D. Curtin, M. Czech, C. Dachauer, R. T. D’Agnolo, M. Daibo, A. Dainese, B. Dalena, A. Daljevec, W. Dallapiazza, L. D’Aloia Schwartzentruber, M. Dam, G. D’Ambrosio, S. P. Das, S. DasBakshi, W. da Silva, G. G. da Silveira, V. D’Auria, S. D’Auria, A. David, T. Davidek, A. Deandrea, J. de Blas, C. J. Debono, S. De Curtis, N. De Filippis, D. de Florian, S. Deghaye, S. J. de Jong, C. Del Bo, V. Del Duca, D. Delikaris, F. Deliot, A. Dell’Acqua, L. Delle Rose, M. Delmastro, E. De Lucia, M. Demarteau, D. Denegri, L. Deniau, D. Denisov, H. Denizli, A. Denner, D. d’Enterria, G. de Rijk, A. De Roeck, F. Derue, O. Deschamps, S. Descotes-Genon, P. S. B. Dev, J. B. de Vivie de Régie, R. K. Dewanjee, A. Di Ciaccio, A. Di Cicco, B. M. Dillon, B. Di Micco, P. Di Nezza, S. Di Vita, A. Doblhammer, A. Dominjon, M. D’Onofrio, F. Dordei, A. Drago, P. Draper, Z. Drasal, M. Drewes, L. Duarte, I. Dubovyk, P. Duda, A. Dudarev, L. Dudko, D. Duellmann, M. Dünser, T. du Pree, M. Durante, H. Duran Yildiz, S. Dutta, F. Duval, J. M. Duval, Ya. Dydyshka, B. Dziewit, S. Eisenhardt, M. Eisterer, T. Ekelof, D. El Khechen, S. A. Ellis, J. Ellis, J. A. Ellison, K. Elsener, M. Elsing, Y. Enari, C. Englert, H. Eriksson, K. J. Eskola, L. S. Esposito, O. Etisken, E. Etzion, P. Fabbricatore, A. Falkowski, A. Falou, J. Faltova, J. Fan, L. Fanò, A. Farilla, R. Farinelli, S. Farinon, D. A. Faroughy, S. D. Fartoukh, A. Faus-Golfe, W. J. Fawcett, G. Felici, L. Felsberger, C. Ferdeghini, A. M. Fernandez Navarro, A. Fernández-Téllez, J. Ferradas Troitino, G. Ferrara, R. Ferrari, L. Ferreira, P. Ferreira da Silva, G. Ferrera, F. Ferro, M. Fiascaris, S. Fiorendi, C. Fiorio, O. Fischer, E. Fischer, W. Flieger, M. Florio, D. Fonnesu, E. Fontanesi, N. Foppiani, K. Foraz, D. Forkel-Wirth, S. Forte, M. Fouaidy, D. Fournier, T. Fowler, J. Fox, P. Francavilla, R. Franceschini, S. Franchino, E. Franco, A. Freitas, B. Fuks, K. Furukawa, S. V. Furuseth, E. Gabrielli, A. Gaddi, M. Galanti, E. Gallo, S. Ganjour, Jia. Gao, Jie. Gao, V. Garcia Diaz, M. García Pérez, L. García Tabarés, C. Garion, M. V. Garzelli, I. Garzia, S. M. Gascon-Shotkin, G. Gaudio, P. Gay, S.-F. Ge, T. Gehrmann, M. H. Genest, R. Gerard, F. Gerigk, H. Gerwig, P. Giacomelli, S. Giagu, E. Gianfelice-Wendt, F. Gianotti, F. Giffoni, S. S. Gilardoni, M. Gil Costa, M. Giovannetti, M. Giovannozzi, P. Giubellino, G. F. Giudice, A. Giunta, L. K. Gladilin, S. Glukhov, J. Gluza, G. Gobbi, B. Goddard, F. Goertz, T. Golling, D. Gonçalves, V. P. Goncalves, R. Gonçalo, L. A. Gonzalez Gomez, S. Gorgi Zadeh, G. Gorine, E. Gorini, S. A. Gourlay, L. Gouskos, F. Grancagnolo, A. Grassellino, A. Grau, E. Graverini, H. M. Gray, Ma. Greco, Mi. Greco, J.-L. Grenard, O. Grimm, C. Grojean, V. A. Gromov, J. F. Grosse-Oetringhaus, A. Grudiev, K. Grzanka, J. Gu, D. Guadagnoli, V. Guidi, S. Guiducci, G. Guillermo Canton, Y. O. Günaydin, R. Gupta, R. S. Gupta, J. Gutierrez, J. Gutleber, C. Guyot, V. Guzey, C. Gwenlan, Ch. Haberstroh, B. Hacışahinoğlu, B. Haerer, K. Hahn, T. Hahn, A. Hammad, C. Han, M. Hance, A. Hannah, P. C. Harris, C. Hati, S. Haug, J. Hauptman, V. Haurylavets, H-J. He, A. Hegglin, B. Hegner, K. Heinemann, S. Heinemeyer, C. Helsens, Ana. Henriques, And. Henriques, P. Hernandez, R. J. Hernández-Pinto, J. Hernandez-Sanchez, T. Herzig, I. Hiekkanen, W. Hillert, T. Hoehn, M. Hofer, W. Höfle, F. Holdener, S. Holleis, B. Holzer, D. K. Hong, C. G. Honorato, S. C. Hopkins, J. Hrdinka, F. Hug, B. Humann, H. Humer, T. Hurth, A. Hutton, G. Iacobucci, N. Ibarrola, L. Iconomidou-Fayard, K. Ilyina-Brunner, J. Incandela, A. Infantino, V. Ippolito, M. Ishino, R. Islam, H. Ita, A. Ivanovs, S. Iwamoto, A. Iyer, S. Izquierdo Bermudez, S. Jadach, D. O. Jamin, P. Janot, P. Jarry, A. Jeff, P. Jenny, E. Jensen, M. Jensen, X. Jiang, J. M. Jiménez, M. A. Jones, O. R. Jones, J. M. Jowett, S. Jung, W. Kaabi, M. Kado, K. Kahle, L. Kalinovskaya, J. Kalinowski, J. F. Kamenik, K. Kannike, S. O. Kara, H. Karadeniz, V. Karaventzas, I. Karpov, S. Kartal, A. Karyukhin, V. Kashikhin, J. Katharina Behr, U. Kaya, J. Keintzel, P. A. Keinz, K. Keppel, R. Kersevan, K. Kershaw, H. Khanpour, S. Khatibi, M. Khatiri Yanehsari, V. V. Khoze, J. Kieseler, A. Kilic, A. Kilpinen, Y.-K. Kim, D. W. Kim, U. Klein, M. Klein, F. Kling, N. Klinkenberg, S. Klöppel, M. Klute, V. I. Klyukhin, M. Knecht, B. Kniehl, F. Kocak, C. Koeberl, A. M. Kolano, A. Kollegger, K. Kołodziej, A. A. Kolomiets, J. Komppula, I. Koop, P. Koppenburg, M. Koratzinos, M. Kordiaczyńska, M. Korjik, O. Kortner, P. Kostka, W. Kotlarski, C. Kotnig, T. Köttig, A. V. Kotwal, A. D. Kovalenko, S. Kowalski, J. Kozaczuk, G. A. Kozlov, S. S. Kozub, A. M. Krainer, T. Kramer, M. Krämer, M. Krammer, A. A. Krasnov, F. Krauss, K. Kravalis, L. Kretzschmar, R. M. Kriske, H. Kritscher, P. Krkotic, H. Kroha, M. Kucharczyk, S. Kuday, A. Kuendig, G. Kuhlmann, A. Kulesza, Mi. Kumar, Mu. Kumar, A. Kusina, S. Kuttimalai, M. Kuze, T. Kwon, F. Lackner, M. Lackner, E. La Francesca, M. Laine, G. Lamanna, S. La Mendola, E. Lançon, G. Landsberg, P. Langacker, C. Lange, A. Langner, A. J. Lankford, J. P. Lansberg, T. Lari, P. J. Laycock, P. Lebrun, A. Lechner, K. Lee, S. Lee, R. Lee, T. Lefevre, P. Le Guen, T. Lehtinen, S. B. Leith, P. Lenzi, E. Leogrande, C. Leonidopoulos, I. Leon-Monzon, G. Lerner, O. Leroy, T. Lesiak, P. Lévai, A. Leveratto, E. Levichev, G. Li, S. Li, R. Li, D. Liberati, M. Liepe, D. A. Lissauer, Z. Liu, A. Lobko, E. Locci, E. Logothetis Agaliotis, M. P. Lombardo, A. J. Long, C. Lorin, R. Losito, A. Louzguiti, I. Low, D. Lucchesi, M. T. Lucchini, A. Luciani, M. Lueckhof, A. J. G. Lunt, M. Luzum, D. A. Lyubimtsev, M. Maggiora, N. Magnin, M. A. Mahmoud, F. Mahmoudi, J. Maitre, V. Makarenko, A. Malagoli, J. Malclés, L. Malgeri, P. J. Mallon, F. Maltoni, S. Malvezzi, O. B. Malyshev, G. Mancinelli, P. Mandrik, P. Manfrinetti, M. Mangano, P. Manil, M. Mannelli, G. Marchiori, F. Marhauser, V. Mariani, V. Marinozzi, S. Mariotto, P. Marquard, C. Marquet, T. Marriott-Dodington, R. Martin, O. Martin, J. Martin Camalich, T. Martinez, H. Martinez Bruzual, M. I. Martínez-Hernández, D. E. Martins, S. Marzani, D. Marzocca, L. Marzola, S. Masciocchi, I. Masina, A. Massimiliano, A. Massironi, T. Masubuchi, V. A. Matveev, M. A. Mazzoni, M. McCullough, P. A. McIntosh, P. Meade, L. Medina, A. Meier, J. Meignan, B. Mele, J. G. Mendes Saraiva, F. Menez, M. Mentink, E. Meoni, P. Meridiani, M. Merk, P. Mermod, V. Mertens, L. Mether, E. Métral, M. Migliorati, A. Milanese, C. Milardi, G. Milhano, B. L. Militsyn, F. Millet, I. Minashvili, J. V. Minervini, L. S. Miralles, D. Mirarchi, S. Mishima, D. P. Missiaen, G. Mitselmakher, T. Mitsuhashi, J. Mnich, M. Mohammadi Najafabadi, R. N. Mohapatra, N. Mokhov, J. G. Molson, R. Monge, C. Montag, G. Montagna, S. Monteil, G. Montenero, E. Montesinos, F. Moortgat, N. Morange, G. Morello, M. Moreno Llácer, M. Moretti, S. Moretti, A. K. Morley, A. Moros, I. Morozov, V. Morretta, M. Morrone, A. Mostacci, S. Muanza, N. Muchnoi, M. Mühlegger, M. Mulder, M. Mulders, B. Müller, F. Müller, A.-S. Müller, J. Munilla, M. J. Murray, Y. Muttoni, S. Myers, M. Mylona, J. Nachtman, T. Nakamoto, M. Nardecchia, G. Nardini, P. Nason, Z. Nergiz, A. V. Nesterenko, A. Nettsträter, C. Neubüser, J. Neundorf, F. Niccoli, O. Nicrosini, Y. Nie, U. Niedermayer, J. Niedziela, A. Niemi, S. A. Nikitin, A. Nisati, J. M. No, M. Nonis, Y. Nosochkov, M. Novák, A. Novokhatski, J. M. O’Callaghan, C. Ochando, S. Ogur, K. Ohmi, K. Oide, V. A. Okorokov, Y. Okumura, C. Oleari, F. I. Olness, Y. Onel, M. Ortino, J. Osborne, P. Osland, T. Otto, K. Y. Oyulmaz, A. Ozansoy, V. Özcan, K. Özdemir, C. E. Pagliarone, H. F. Pais da Silva, E. Palmieri, L. Palumbo, A. Pampaloni, R.-Q. Pan, M. Panareo, O. Panella, G. Panico, G. Panizzo, A. A. Pankov, V. Pantsyrny, C. G. Papadopoulos, A. Papaefstathiou, Y. Papaphilippou, M. A. Parker, V. Parma, M. Pasquali, S. K. Patra, R. Patterson, H. Paukkunen, F. Pauss, S. Peggs, J.-P. Penttinen, G. Peón, E. E. Perepelkin, E. Perez, J. C. Perez, G. Perez, F. Pérez, E. Perez Codina, J. Perez Morales, M. Perfilov, H. Pernegger, M. Peruzzi, C. Pes, K. Peters, S. Petracca, F. Petriello, L. Pezzotti, S. Pfeiffer, F. Piccinini, T. Pieloni, M. Pierini, H. Pikhartova, G. Pikurs, E. Pilicer, P. Piminov, C. Pira, R. Pittau, W. Płaczek, M. Plagge, T. Plehn, M.-A. Pleier, M. Płoskoń, M. Podeur, H. Podlech, T. Podzorny, L. Poggioli, A. Poiron, G. Polesello, M. Poli Lener, A. Polini, J. Polinski, S. M. Polozov, L. Ponce, M. Pont, L. Pontecorvo, T. Portaluri, K. Potamianos, C. Prasse, M. Prausa, A. Preinerstorfer, E. Premat, T. Price, M. Primavera, F. Prino, M. Prioli, J. Proudfoot, A. Provino, T. Pugnat, N. Pukhaeva, S. Puławski, D. Pulikowski, G. Punzi, M. Putti, A. Pyarelal, H. Quack, M. Quispe, A. Racioppi, H. Rafique, V. Raginel, M. Raidal, N. S. Ramírez-Uribe, M. J. Ramsey-Musolf, R. Rata, P. Ratoff, F. Ravotti, P. Rebello Teles, M. Reboud, S. Redaelli, E. Renner, A. E. Rentería-Olivo, M. Rescigno, J. Reuter, A. Ribon, A. M. Ricci, W. Riegler, S. Riemann, B. Riemann, T. Riemann, J. M. Rifflet, R. A. Rimmer, R. Rinaldesi, L. Rinolfi, O. Rios Rubiras, T. Risselada, A. Rivetti, L. Rivkin, T. Rizzo, T. Robens, F. Robert, A. J. Robson, E. Rochepault, C. Roda, G. Rodrigo, M. Rodríguez-Cahuantzi, C. Rogan, M. Roig, S. Rojas-Torres, J. Rojo, G. Rolandi, G. Rolando, P. Roloff, A. Romanenko, A. Romanov, F. Roncarolo, A. Rosado Sanchez, G. Rosaz, L. Rossi, A. Rossi, R. Rossmanith, B. Rousset, C. Royon, X. Ruan, I. Ruehl, V. Ruhlmann-Kleider, R. Ruiz, L. Rumyantsev, R. Ruprecht, A. I. Ryazanov, A. Saba, R. Sadykov, D. Saez de Jauregui, M. Sahin, B. Sailer, M. Saito, F. Sala, G. P. Salam, J. Salfeld-Nebgen, C. A. Salgado, S. Salini, J. M. Sallese, T. Salmi, A. Salzburger, O. A. Sampayo, S. Sanfilippo, J. Santiago, E. Santopinto, R. Santoro, A. Sanz Ull, X. Sarasola, I. H. Sarpün, M. Sauvain, S. Savelyeva, R. Sawada, G. F. R. Sborlini, A. Schaffer, M. Schaumann, M. Schenk, C. Scheuerlein, I. Schienbein, K. Schlenga, H. Schmickler, R. Schmidt, D. Schoerling, A. Schoning, T. Schörner-Sadenius, M. Schott, D. Schulte, P. Schwaller, C. Schwanenberger, P. Schwemling, N. Schwerg, L. Scibile, A. Sciuto, E. Scomparin, C. Sebastiani, B. Seeber, M. Segreti, P. Selva, M. Selvaggi, C. Senatore, A. Senol, L. Serin, M. Serluca, N. Serra, A. Seryi, L. Sestini, A. Sfyrla, M. Shaposhnikov, E. Shaposhnikova, B. Yu. Sharkov, D. Shatilov, J. Shelton, V. Shiltsev, I. P. Shipsey, G. D. Shirkov, A. Shivaji, D. Shwartz, T. Sian, S. Sidorov, A. Siemko, L. Silvestrini, N. Simand, F. Simon, B. K. Singh, A. Siódmok, Y. Sirois, E. Sirtori, R. Sirvinskaite, B. Sitar, T. Sjöstrand, P. Skands, E. Skordis, K. Skovpen, M. Skrzypek, E. Slade, P. Slavich, R. Slovak, V. Smaluk, V. Smirnov, W. Snoeys, L. Soffi, P. Sollander, O. Solovyanov, H. K. Soltveit, H. Song, P. Sopicki, M. Sorbi, L. Spallino, M. Spannowsky, B. Spataro, P. Sphicas, H. Spiesberger, P. Spiller, M. Spira, T. Srivastava, J. Stachel, A. Stakia, J. L. Stanyard, E. Starchenko, A. Yu. Starikov, A. M. Staśto, M. Statera, R. Steerenberg, J. Steggemann, A. Stenvall, F. Stivanello, D. Stöckinger, L. S. Stoel, M. Stöger-Pollach, B. Strauss, M. Stuart, G. Stupakov, S. Su, A. Sublet, K. Sugita, L. Sulak, M. K. Sullivan, S. Sultansoy, T. Sumida, K. Suzuki, G. Sylva, M. J. Syphers, A. Sznajder, M. Taborelli, N. A. Tahir, E. Tal Hod, M. Takeuchi, C. Tambasco, J. Tanaka, K. Tang, I. Tapan, S. Taroni, G. F. Tartarelli, G. Tassielli, L. Tavian, T. M. Taylor, G. N. Taylor, A. M. Teixeira, G. Tejeda-Muñoz, V. I. Telnov, R. Tenchini, H. H. J. ten Kate, K. Terashi, A. Tesi, M. Testa, C. Tetrel, D. Teytelman, J. Thaler, A. Thamm, S. Thomas, M. T. Tiirakari, V. Tikhomirov, D. Tikhonov, H. Timko, V. Tisserand, L. M. Tkachenko, J. Tkaczuk, J. Ph. Tock, B. Todd, E. Todesco, R. Tomás Garcia, D. Tommasini, G. Tonelli, F. Toral, T. Torims, R. Torre, Z. Townsend, R. Trant, D. Treille, L. Trentadue, A. Tricoli, A. Tricomi, W. Trischuk, I. S. Tropin, B. Tuchming, A. A. Tudora, B. Turbiarz, I. Turk Cakir, M. Turri, T. Tydecks, J. Usovitsch, J. Uythoven, R. Vaglio, A. Valassi, F. Valchkova, M. A. Valdivia Garcia, P. Valente, R. U. Valente, A.-M. Valente-Feliciano, G. Valentino, L. Vale Silva, J. M. Valet, R. Valizadeh, J. W. F. Valle, S. Vallecorsa, G. Vallone, M. van Leeuwen, U. H. van Rienen, L. van Riesen-Haupt, M. Varasteh, L. Vecchi, P. Vedrine, G. Velev, R. Veness, A. Ventura, W. Venturini Delsolaro, M. Verducci, C. B. Verhaaren, C. Vernieri, A. P. Verweij, O. Verwilligen, O. Viazlo, A. Vicini, G. Viehhauser, N. Vignaroli, M. Vignolo, A. Vitrano, I. Vivarelli, S. Vlachos, M. Vogel, D. M. Vogt, V. Völkl, P. Volkov, G. Volpini, J. von Ahnen, G. Vorotnikov, G. G. Voutsinas, V. Vysotsky, U. Wagner, R. Wallny, L.-T. Wang, R. Wang, K. Wang, B. F. L. Ward, T. P. Watson, N. K. Watson, Z. Wa̧s, C. Weiland, S. Weinzierl, C. P. Welsch, J. Wenninger, M. Widorski, U. A. Wiedemann, H.-U. Wienands, G. Wilkinson, P. H. Williams, A. Winter, A. Wohlfahrt, T. Wojtoń, D. Wollmann, J. Womersley, D. Woog, X. Wu, A. Wulzer, M. K. Yanehsari, G. Yang, H. J. Yang, W.-M. Yao, E. Yazgan, V. Yermolchik, Ay. Yilmaz, Al. Yilmaz, H.-D. Yoo, S. A. Yost, T. You, C. Young, T.-T. Yu, F. Yu, A. Zaborowska, S. G. Zadeh, M. Zahnd, M. Zanetti, L. Zanotto, L. Zawiejski, P. Zeiler, M. Zerlauth, S. M. Zernov, G. Zevi Dell Porta, Z. Zhang, Y. Zhang, C. Zhang, H. Zhang, Z. Zhao, Y.-M. Zhong, J. Zhou, D. Zhou, P. Zhuang, G. Zick, F. Zimmermann, J. Zinn-Justin, L. Zivkovic, A. V. Zlobin, M. Zobov, J. Zupan, J. Zurita, and The FCC Collaboration

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract We review the physics opportunities of the Future Circular Collider, covering its e+e-, pp, ep and heavy ion programmes. We describe the measurement capabilities of each FCC component, addressing the study of electroweak, Higgs and strong interactions, the top quark and flavour, as well as phenomena beyond the Standard Model. We highlight the synergy and complementarity of the different colliders, which will contribute to a uniquely coherent and ambitious research programme, providing an unmatchable combination of precision and sensitivity to new physics.

Published
2019
Full Text
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4. APLIKASI INJEKTOR PADA TUNGKU PELEBURAN PERUNGGU UNTUK MENINGKATKAN KINERJA PRODUKSI GAMELAN BALI

Author

I G N Priambadi, I. G. K Sugita, I Putu Lokantara, I. M. Parwata, and K Astawa

Subjects
General Works
Abstract

Gamelan melting process (casting) plays a role in the process of making Balinese gamelan. Furnace is a major component in this melting process. Craftmen use traditional melting furnace with an open form in which the air flow is needed in the injector fuel combustion using the straight shape. Injector of this model provides less air flow evenly so that the combustion process takes quite a long time. Ergo thermal injector has been introduced in service activities in the village craftmen group Tihingan Banjarangkan District of Klungkung. This furnace has the airflow coming out of the blower which then flows in a flow-shaped convergent-divergent. The function of this model is that the pressure of the incoming air flow passes into the air injectors to increase and spread evenly in the furnace chamber. Craftmen were trained directly how to make this model kitchen and directly transform traditional stoves with models furnace injector is introduced. The results showed that the combustion of fuel use was decreased by 12.96%. Fuel savings resulting from the latest injector models can provide the required distribution of air in the combustion process fuel (charcoal) to be more perfect and resulting high temperatures generated high. Supply of combustion air more evenly on the charcoal have an impact on the optimum combustion processKeywords: gamelan, injector, bronze alloys, smelting

Published
2014

5. HE-LHC: The High-Energy Large Hadron Collider Future Circular Collider Conceptual Design Report Volume 4

Author

Pushpalatha C Bhat, B. Seeber, C. Pagliarone, Marco Statera, Victor P. Goncalves, Daria Astapovych, W. Bartmann, S. Iwamoto, M. Mentink, Alessandro Tricoli, E. R. Bielert, Laurent Chevalier, Patrick Koppenburg, Marco Calviani, C. Montag, P. Spiller, Jan Uythoven, P. Di Nezza, G. Guillermo Canton, B. Sailer, Markus Elsing, Sara Khatibi, Luca Vecchi, Luigi Palumbo, J. P. Penttinen, T. Podzorny, Maneesh Kumar, J. M. Rifflet, C. Kotnig, Jean Zinn-Justin, Christopher B. Verhaaren, A. Chernoded, Alessandro Bertarelli, L. M. Tkachenko, C. Koeberl, P. J. Mallon, M. Takeuchi, W. Venturini Delsolaro, G. Lamanna, S. Weinzierl, J. Gao, W. Kaabi, David D'Enterria, D. Barna, Paolo Castelnovo, Rajat Gupta, Oliver Boine-Frankenheim, Adarsh Pyarelal, Andreas Salzburger, Tessa Charles, M.E. Biagini, O. Panella, M. Stuart, A. Kollegger, V. Garcia Diaz, Olcay Bolukbasi, Maurizio Pierini, H. Aksakal, Tord Riemann, Abhishek M. Iyer, V. Shiltsev, D. Buttazzo, J. Blümlein, Prateek Agrawal, L. Sestini, Martin Bauer, Felicitas Pauss, S. Fiorendi, F. Bossu, Marco Nardecchia, C. Leonidopoulos, Wojciech Kotlarski, A. Saba, I. Bautista-Guzmán, W. Hillert, Giorgio Ambrosio, T. Lehtinen, Michael Andrew Parker, Silvia Taroni, Gian F. Giudice, Ph. Lebrun, Johann A. Briffa, T. Risselada, Giuseppe Lerner, A. Lechner, L. S. Miralles, M. Kuze, J. M. Valet, P. S. B. Dev, S. Holleis, Ph. Schwemling, M. Biglietti, S. Banerjee, Thomas Schörner-Sadenius, A. Sanz Ull, V. Tikhomirov, S. Savelyeva, Jiayin Gu, D. Zhou, Federico Ravotti, S. A. Bogacz, Daniele Mirarchi, R. Tomás García, Yann Coadou, F. Yu, Y. Cai, T. Lari, F. Holdener, D. Shwartz, C. Bhat, Ramesh Gupta, Markus Klute, E. Palmieri, P. Collier, Branislav Sitar, Yves Sirois, Livio Fanò, S. Rojas-Torres, E. Locci, Ruben Garcia Alia, I. Božović Jelisavić, R. Chehab, J. A. Aguilar-Saavedra, M. Pasquali, A. Di Cicco, Bernhard Auchmann, Klaus Heinemann, Alessia Tricomi, D. Lucchesi, B. Haerer, M. Morrone, Paolo Giacomelli, Sonia Carra, A. Senol, Ivan Koop, Luca Silvestrini, Anna Stakia, Heather Gray, E. Skordis, A. D. Kovalenko, Paul Langacker, R. Li, Bernardo Bordini, R. Rata, Arjan Verweij, Shehu S. AbdusSalam, Andrey Karyukhin, U. van Rienen, Gianluigi Arduini, Bernhard Holzer, S. A. Nikitin, S. S. Kozub, Satoshi Mishima, B. Di Micco, S. Izquierdo Bermudez, N. Pukhaeva, Nigel Watson, F. Prino, Jean-Michel Sallese, Sotirios Vlachos, Alessandro Vicini, A. Valassi, Daniel Treille, F. Dordei, A. M. Fernandez Navarro, B. Dziewit, Marcello Abbrescia, J. M. Hauptman, I. Chaikovska, Paolo Giubellino, Michael J. Baker, V.V. Kashikhin, Friedrich Lackner, Filippo Sala, A. Langner, D. Pulikowski, H. Eriksson, Matteo Turri, Andrea Wulzer, M. Aiba, Lisa Borgonovi, I. Morozov, V. Haurylavets, J. F. Croteau, S. Boselli, L. A. Gonzalez Gomez, Claudia Tambasco, F. Mahmoudi, Sébastien Descotes-Genon, A. Luciani, Pavel Piminov, M. Varasteh, T. Herzig, Sandra Aumon, Cristina Bernini, Joseph Bramante, Roberta Arnaldi, G. Zick, Daniel Schulte, R. Santoro, Anna Kulesza, I. Turk Cakir, M. Nonis, Silvia Posada Arias, Livia Soffi, T. Wojtoń, E. Cennini, Florian Bauer, B. Rousset, J.-L. Grenard, C. Neubüser, Frederic Derue, Loukas Gouskos, Rainer Wallny, G. Calderini, M. Merk, M. Mühlegger, Roberto Cimino, M. Ramsey-Musolf, P. Rebello Teles, Mario Galanti, Mikhail Shaposhnikov, A. Andreazza, Maria Vittoria Garzelli, Masaya Ishino, José W. F. Valle, Colin Bernet, G. Velev, Cristina Botta, E. Fischer, J. Malclés, Giuseppe Montenero, Tripurari Srivastava, E. Renner, Shahnam Gorgi Zadeh, D. Cantore-Cavalli, Paul Laycock, J. Komppula, Simon C. Hopkins, Helmut Burkhardt, Eric Lancon, I. Aichinger, Andre Sznajder, F. Bordry, Massimo Giovannozzi, Aidan Robson, Anna Giunta, A. Carvalho, S. Farinon, Daniel Wollmann, M. Fouaidy, Martti Raidal, R. Gerard, Giovanni Volpini, U. Niedermayer, A. Alekou, Alexander J.G. Lunt, Vincenzo Cavasinni, Andrzej Siodmok, U. Kaya, Matthias Schott, Marumi Kado, S. A. Arsenyev, José Zurita, John Osborne, Patrick Meade, Gianmarco Bovone, G. Li, Klaus Schlenga, Antti Stenvall, D. Duellmann, Werner Riegler, I. Garzia, Yasuyuki Okumura, G. Pikurs, F. Maltoni, Massimo Sorbi, M. Arzeo, B. Strauss, Y. W. Baek, Mauro Chiesa, K. Ilyina-Brunner, Javier L. Albacete, R. Farinelli, C. Pes, Nicolas Morange, S. M. Zernov, U. Wagner, Emmanuelle Perez, G. G. Da Silveira, J. Neundorf, Néstor Armesto, T. Hahn, Roman N. Lee, Roderik Bruce, B. Y. Sharkov, T. du Pree, G. Cibinetto, Evelin Meoni, R. Rinaldesi, James A. Ellison, Radim Slovak, Silvia Franchino, Mikko Laine, T. Pugnat, S. P. Das, Yuji Enari, Emanuela Barzi, Cihan Bayindir, R. Boels, Jana Faltova, M. Moreno Llácer, Scott A. Yost, Michael Spannowsky, Florian Burkart, Marcin Chrzaszcz, K. Suzuki, Luca Trentadue, S. Masciocchi, Gilad Perez, Steve Peggs, K. Sugita, Eleonora Belli, Carmine Senatore, K. Y. Oyulmaz, Aldo Deandrea, Irakli Minashvili, Desmond P. Barber, M. I. Martínez-Hernández, A. Apyan, S. Petracca, Mikael Chala, Urs Achim Wiedemann, T. Sian, Olivier Deschamps, R. Monge, G. Avrillaud, Jan Kieseler, Hubert Spiesberger, J. Maitre, G. D. Shirkov, M. Hofer, Emanuela Sirtori, Sinan Kuday, Kirill Skovpen, Sara Casalbuoni, Johann Usovitsch, N. Chen, G. Tejeda-Muñoz, F. Bellini, E. Chyhyrynets, Michael Stöger-Pollach, M. Vogel, J. G. Mendes Saraiva, A. Rivetti, M. Podeur, Luc Poggioli, V. A. Gromov, R. Sirvinskaite, S. B. Leith, Giancarlo D'Ambrosio, Tony Price, Philippe Mermod, Rabindra N. Mohapatra, T. Mitshuhashi, Koji Terashi, Leonel Ferreira, L. Vale Silva, N. Muchnoi, J. L. Stanyard, Thomas Marriott-Dodington, A. Andriatis, Oleg Solovyanov, A. Daljevec, A. Butterworth, S. Myers, D. Chanal, Tatiana Pieloni, M. Rodríguez-Cahuantzi, G. Nardini, D. Boscherini, Kazuhito Ohmi, James Molson, S. Kowalski, Christoph Haberstroh, Martin Aleksa, K. Kershaw, M. Mulder, Leonid Rivkin, G. Vorotnikov, Luigi Salvatore Esposito, J. Kalinowski, Michele Cascella, Francesco Giffoni, Alessandro Polini, Georges Azuelos, M. Prioli, Wolfgang Altmannshofer, S. K. Patra, H. J. He, J. J. Aguilera-Verdugo, Hannu Paukkunen, P. Chomaz, Shoji Asai, Nicolas Magnin, Gavin P. Salam, R. Wang, F. Avino, Alexander Romanenko, A. Rossi, Steve Muanza, Richard Ruiz, Dmitry Teytelman, S. Klöppel, S. Atieh, M. Mohammadi Najafabadi, L. Apolinario, Andrea Tesi, M. Maggiora, A. Falkowski, Janusz Gluza, M. Sauvain, Hamzeh Khanpour, S. Chance, Ansgar Denner, Ma. Greco, Andreas Papaefstathiou, Manuela Boscolo, Joydeep Chakrabortty, E. Franco, R. R. Bosley, G. Peón, Fred Olness, Simone Alioli, Andrea Gaddi, M. K. Sullivan, M. Segreti, M. Panareo, Florian Goertz, Z. G. Zhao, H. Chanal, O. Martin, P. Azzurri, Agnieszka Chmielinska, M. Kordiaczyńska, O. Brunner, J. Von Ahnen, Jose Santiago, K. Foraz, Y. Alexahin, Marcello Mannelli, Christian Schwanenberger, S. Ganjour, Simone Marzani, T. M. Taylor, S. Di Vita, J. Womersley, I. Karpov, Valentina Morretta, Saverio D'Auria, Patrick Draper, B. Hacışahinoğlu, E. Gorini, Andrew J. Long, S. La Mendola, G. Zevi Dell Porta, I. Abdyukhanov, M. Cobal, Luca Marzola, E. Rochepault, A. Kusina, German Rodrigo, R. Schmidt, Jan Steggemann, E. Premat, P. Slavich, F. Gianotti, P. Jarry, Ram Krishna Dewanjee, L. Felsberger, T. Martinez, A. Niemi, Jürgen Reuter, P. A. Bruckman de Renstrom, Ryu Sawada, J. T. Childers, Gelsomina Catalano, P. Barjhoux, O. R. Blanco-García, Pilar Hernández, H. Correia-Rodrigues, V. Ippolito, S. De Curtis, Juan Rojo, Ayberk Yilmaz, S. Baird, Morteza Khatiri Yanehsari, Enrico Scomparin, Daniel Appelö, J. Kozaczuk, Matthew Jones, B. Caiffi, C. Del Bo, Susanna Guiducci, Giuliano Panico, M. Knecht, J. Coupard, M. Ciuchini, H. Kritscher, Claire Gwenlan, P. Costa Pinto, Thibaut Lefèvre, N. Bellegarde, Christian Scheuerlein, P. Ferreira da Silva, M. Verducci, X. Ruan, H. Pikhartova, Juan M. O'Callaghan, Kazuro Furukawa, D. Saez de Jauregui, Maria Rescigno, Stephan Eisenhardt, Andrea Dainese, Z. Drásal, G. H. Corral, J. M. Camalich, John Ellis, E. Gabrielli, L. Rumyantsev, A. Caliskan, K. Brunner, K. Tang, P. Sopicki, J. Fan, Marcin Kucharczyk, S. Gorgi Zadeh, Carlos A. Salgado, Simone Bologna, Y. Muttoni, A. Chancé, Patrick Jenny, Mark Boland, G. Yang, G. Wilkinson, Roger J. Hernández-Pinto, M. Novák, Gennady Stupakov, E. Jensen, Lance D. Cooley, Torbjörn Sjöstrand, S. Su, Matthew Luzum, J. Casas, Per Osland, T. Robens, Oscar A. Sampayo, Evgeny Levichev, P. N. Ratoff, G. Rolandi, M. A. Valdivia Garcia, Anthony Keith Morley, L. van Riesen-Haupt, A. Sublet, M. A. Mazzoni, J.L. Gutierrez, A. Abramov, Abbas Kenan Ciftci, A. Provino, L. Delle Rose, John Fox, Barry M. Dillon, V. Smirnov, G. N. Taylor, Anke-Susanne Müller, C. Pira, Fulvio Piccinini, A. Faus-Golfe, Pietro Antonioli, S. Sanfilippo, Julien Cogan, A. Ribon, Andrew Hutton, Frank Zimmermann, Lev Dudko, Erez Etzion, J. Polinski, G. Bencivenni, M. Gil Costa, L. K. Gladilin, Yannis Papaphilippou, Michael Spira, Maria Paola Lombardo, M. Fiascaris, Darius A. Faroughy, S. O. Kara, Peter Braun-Munzinger, A. Wohlfahrt, A. A. Krasnov, S.A. Gourlay, W. Da Silva, Jacqueline Keintzel, Radja Boughezal, Renat Sadykov, L. R. Sulak, Valentin V. Khoze, T. Tydecks, S. Puławski, Daniel de Florian, Pedro Schwaller, A. Akay, Nicola Serra, Sukanta Dutta, Christophe Royon, Alessandro Ricci, A. Kuendig, C. G. Honorato, K. Kołodziej, L. Deniau, Michael Kramer, J. Ferradas Troitino, A. Arbey, A. M. Staśto, Marcel Demarteau, Ralph Aßmann, O. Grimm, D. Forkel-Wirth, Owain Rhodri Jones, A. M. Kolano, G. Chiarello, William Trischuk, Andrea Dell'Acqua, Elisabetta Gallo, H. Song, Frank Petriello, N. Ibarrola, C. Colldelram, A. I. Ryazanov, A. Meier, Phillip Allport, J. de Blas, S. Chattopadhyay, Massimo Florio, X. Jiang, Bertrand Baudouy, T. Otto, Tevong You, Christoph Englert, Roberto Pittau, G. M. Bilei, Matthew McCullough, N. S. Ramírez-Uribe, J. Charles, Amalia Ballarino, Federico Antinori, A. V. Kotwal, P. Le Guen, Berndt Müller, Chiara Roda, Xavier Buffat, D. K. Hong, Matthias Liepe, G. Gorine, V. A. Okorokov, D. Bozzini, N. Simand, Giuseppe Francesco Tartarelli, C. Marquet, R. Contino, A. M. Teixeira, R. Trant, Roberto Losito, M. Quispe, Valery I. Telnov, Helga Timko, D. Lissauer, Giulio Aielli, Giorgio Chiarelli, M. J. Baldwin, A. Winter, X. Sarasola, E. E. Boos, Aleandro Nisati, Cedric Garion, Monica D'Onofrio, S. M. Gascon-Shotkin, Daniele Barducci, G. Rosaz, Nathaniel Craig, L. D’Aloia Schwartzentruber, A. Falou, A. Henriques, Tobias Hurth, Michael Eisterer, Andreas Grau, Austin Ball, D. Delikaris, P. A. McIntosh, E. Graverini, Kadri Ozdemir, F. Valchkova, Marco Zanetti, Guenakh Mitselmakher, S. Albergo, Peter Levai, Caterina Vernieri, F. Stivanello, Michael Barnes, Henri Bachacou, Daniel Fournier, L. T. Wang, D. Boutin, S. Moretti, B. Riemann, Michael Murray, Aleksandr Azatov, C. T. A. Cook, Valentina Maria Cairo, J. B. De Vivie De Regie, H. Schmickler, M. Schenk, Georgios Voutsinas, André Schöning, S. G. Bondarenko, Giorgio Bellomo, Andrei Seryi, Jane Nachtman, Clement Helsens, E. De Lucia, Jakob Salfeld-Nebgen, Lorenzo Pezzotti, Z. Townsend, B. Dalena, Mogens Dam, Yasar Onel, Yi-Ming Zhong, B. Curé, A. A. Kolomiets, A. M. Valente-Feliciano, Laurette Ponce, David Olivier Jamin, P. Krkotic, Alexandre Louzguiti, Marina Putti, Holger Podlech, Petr Volkov, M. Angelucci, F. Duval, I. Hiekkanen, W. M. Yao, Giancarlo Ferrera, C. Lorin, Y. Dydyshka, Kurt R. Peters, Gergely Gabor Barnafoldi, V. Vysotsky, V. Arı, E. Pilicer, M. Chamizo-Llatas, G. Kuhlmann, Hans Quack, R. Valizadeh, Tiina Salmi, Thomas Kramer, Adam Jeff, A. Abada, J. M. Duval, J. Abelleira Fernandez, A. Leveratto, E. Tal Hod, X. Wu, Laurent Serin, Sarah Aull, Samuele Mariotto, A. Poiron, Sabine Riemann, P. Selva, V. I. Pantsyrny, Gianluca Valentino, K. Kahle, S. Aune, K. Potamianos, Eros Cazzato, M. Giovannetti, Petr Mandrik, S. Sidorov, F. Collamati, Simone Gilardoni, S. Bertolucci, Alexander V. Zlobin, Mehmet Sahin, Marco Delmastro, G. Aydın, A. Doblhammer, Alan S. Cornell, S. J. De Jong, M. Caccia, M. Lueckhof, P. Sollander, Mauro Taborelli, J. Shelton, Frank Gerigk, Robert Rimmer, Ayres Freitas, Pierluigi Bruzzone, Brajesh K. Singh, K. Keppel, N. Alipour Tehrani, C. Prasse, Louis Rinolfi, Emma Slade, W. Flieger, Alexey Dudarev, H. J. Yang, T. Köttig, L. Mether, C. Weiland, Andrea Malagoli, Sunghoon Jung, F. Conventi, I. Tropin, G. H. A. Viehhauser, Tomas Davidek, Y. O. Günaydin, Daniel Andreas Britzger, F. Toral, James John Brooke, R. Steerenberg, G. Morello, Mauro Migliorati, Alexej Grudiev, C. Tetrel, Wolfgang Höfle, J. V. Minervini, L. García Tabarés, V. Yermolchik, Claude Guyot, D. Guadagnoli, Giorgio Vallone, N. De Filippis, Oleksii Beznosov, P. Charitos, N. Schwerg, Ahmed Hammad, P. Manil, F. Niccoli, Lydia Iconomidou-Fayard, R. Aleksan, K. Hahn, P. Meridiani, Peter Skands, Tobias Golling, Lucio Rossi, G. 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Han, Olivier Leroy, R. T. D’Agnolo, N. Klinkenberg, A. Audurier, Tatsushi Nakamoto, Ali Bozbey, Bernd A. Kniehl, Carl J. Debono, I. P. J. Shipsey, Gregorio Bernardi, Paolo Nason, William James Fawcett, J. M. Jiménez, D. Denisov, M. Serluca, David Curtin, Arif Akhundov, M. García Pérez, Iacopo Vivarelli, Emanuele Bacchiocchi, Markus Zerlauth, Julia Hrdinka, F. Butin, F. Müller, D. Tikhonov, Jorg Wenninger, A. Kilic, Fabrizio Ferro, J. Tanaka, S. A. Antipov, Miroslav Atanasov, S. Kuttimalai, A. Y. Starikov, F. R. Blánquez, S. V. Furuseth, G. Gaudio, L. Malgeri, J. Curti, B. Turbiarz, S. Li, A. Romanov, Costas G. Papadopoulos, Brennan Goddard, Frank Krauss, Lidija Zivkovic, Toms Torims, Michaela Lackner, D. A. Lyubimtsev, G. Borghello, J. F. Grosse-Oetringhaus, A. Bogomyagkov, H. Duran Yildiz, N. Foppiani, Arthur Schaffer, J. Zhou, D. Liberati, Vincenzo Guidi, Naeem A. Tahir, M. Besançon, Daniel Schoerling, Joe Incandela, Giacomo Polesello, O. Cakir, I. Ruehl, Ruggero Vaglio, Z. 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Zurita, J, Işık Üniversitesi, Mühendislik Fakültesi, İnşaat Mühendisliği Bölümü, Işık University, Faculty of Engineering, Department of Civil Engineering, Bayındır, Cihan, Universitat Politècnica de Catalunya. Departament de Teoria del Senyal i Comunicacions, Universitat Politècnica de Catalunya. RF&MW - Grup de Recerca de sistemes, dispositius i materials de RF i microones, Abada A., Abbrescia M., AbdusSalam S.S., Abdyukhanov I., Abelleira Fernandez J., Abramov A., Aburaia M., Acar A.O., Adzic P.R., Agrawal P., Aguilar-Saavedra J.A., Aguilera-Verdugo J.J., Aiba M., Aichinger I., Aielli G., Akay A., Akhundov A., Aksakal H., Albacete J.L., Albergo S., Alekou A., Aleksa M., Aleksan R., Alemany Fernandez R.M., Alexahin Y., Alia R.G., Alioli S., Alipour Tehrani N., Allanach B.C., Allport P.P., Altinli M., Altmannshofer W., Ambrosio G., Amorim D., Amstutz O., Anderlini L., Andreazza A., Andreini M., Andriatis A., Andris C., Andronic A., Angelucci M., Antinori F., Antipov S.A., Antonelli M., Antonello M., Antonioli P., Antusch S., Anulli F., Apolinario L., Apollinari G., Apollonio A., Appelo D., Appleby R.B., Apyan A., Arbey A., Arbuzov A., Arduini G., Ari V., Arias S., Armesto N., Arnaldi R., Arsenyev S.A., Arzeo M., Asai S., Aslanides E., Assmann R.W., Astapovych D., Atanasov M., Atieh S., Attie D., Auchmann B., Audurier A., Aull S., Aumon S., Aune S., Avino F., Avrillaud G., Aydin G., Azatov A., Azuelos G., Azzi P., Azzolini O., Azzurri P., Bacchetta N., Bacchiocchi E., Bachacou H., Baek Y.W., Baglin V., Bai Y., Baird S., Baker M.J., Baldwin M.J., Ball A.H., Ballarino A., Banerjee S., Barber D.P., Barducci D., Barjhoux P., Barna D., Barnafoldi G.G., Barnes M.J., Barr A., Barranco Garcia J., Barreiro Guimaraes da Costa J., Bartmann W., Baryshevsky V., Barzi E., Bass S.A., Bastianin A., Baudouy B., Bauer F., Bauer M., Baumgartner T., Bautista-Guzman I., Bayindir C., Beaudette F., Bedeschi F., Beguin M., Bellafont I., Bellagamba L., Bellegarde N., Belli E., Bellingeri E., Bellini F., Bellomo G., Belomestnykh S., Bencivenni G., Benedikt M., Bernardi G., Bernardi J., Bernet C., Bernhardt J.M., Bernini C., Berriaud C., Bertarelli A., Bertolucci S., Besana M.I., Besancon M., Beznosov O., Bhat P., Bhat C., Biagini M.E., Biarrotte J.-L., Bibet Chevalier A., Bielert E.R., Biglietti M., Bilei G.M., Bilki B., Biscari C., Bishara F., Blanco-Garcia O.R., Blanquez F.R., Blekman F., Blondel A., Blumlein J., Boccali T., Boels R., Bogacz S.A., Bogomyagkov A., Boine-Frankenheim O., Boland M.J., Bologna S., Bolukbasi O., Bomben M., Bondarenko S., Bonvini M., Boos E., Bordini B., Bordry F., Borghello G., Borgonovi L., Borowka S., Bortoletto D., Boscherini D., Boscolo M., Boselli S., Bosley R.R., Bossu F., Botta C., Bottura L., Boughezal R., Boutin D., Bovone G., Bozovic Jelisavic I., Bozbey A., Bozzi C., Bozzini D., Braccini V., Braibant-Giacomelli S., Bramante J., Braun-Munzinger P., Briffa J.A., Britzger D., Brodsky S.J., Brooke J.J., Bruce R., Bruckman De Renstrom P., Bruna E., Bruning O., Brunner O., Brunner K., Bruzzone P., Buffat X., Bulyak E., Burkart F., Burkhardt H., Burnet J.-P., Butin F., Buttazzo D., Butterworth A., Caccia M., Cai Y., Caiffi B., Cairo V., Cakir O., Calaga R., Calatroni S., Calderini G., Calderola G., Caliskan A., Calvet D., Calviani M., Camalich J.M., Camarri P., Campanelli M., Camporesi T., Canbay A.C., Canepa A., Cantergiani E., Cantore-Cavalli D., Capeans M., Cardarelli R., Cardella U., Cardini A., Carloni Calame C.M., Carra F., Carra S., Carvalho A., Casalbuoni S., Casas J., Cascella M., Castelnovo P., Castorina G., Catalano G., Cavasinni V., Cazzato E., Cennini E., Cerri A., Cerutti F., Cervantes J., Chaikovska I., Chakrabortty J., Chala M., Chamizo-Llatas M., Chanal H., Chanal D., Chance S., Chance A., Charitos P., Charles J., Charles T.K., Chattopadhyay S., Chehab R., Chekanov S.V., Chen N., Chernoded A., Chetvertkova V., Chevalier L., Chiarelli G., Chiarello G., Chiesa M., Chiggiato P., Childers J.T., Chmielinska A., Cholakian A., Chomaz P., Chorowski M., Chou W., Chrzaszcz M., Chyhyrynets E., Cibinetto G., Ciftci A.K., Ciftci R., Cimino R., Ciuchini M., Clark P.J., Coadou Y., Cobal M., Coccaro A., Cogan J., Cogneras E., Collamati F., Colldelram C., Collier P., Collot J., Contino R., Conventi F., Cook C.T.A., Cooley L., Corcella G., Cornell A.S., Corral G.H., Correia-Rodrigues H., Costanza F., Costa Pinto P., Couderc F., Coupard J., Craig N., Crespo Garrido I., Crivellin A., Croteau J.F., Crouch M., Cruz Alaniz E., Cure B., Curti J., Curtin D., Czech M., Dachauer C., D'Agnolo R.T., Daibo M., Dainese A., Dalena B., Daljevec A., Dallapiazza W., D'Aloia Schwartzentruber L., Dam M., D'Ambrosio G., Das S.P., DasBakshi S., da Silva W., da Silveira G.G., D'Auria V., D'Auria S., David A., Davidek T., Deandrea A., de Blas J., Debono C.J., De Curtis S., De Filippis N., de Florian D., Deghaye S., de Jong S.J., Del Bo C., Del Duca V., Delikaris D., Deliot F., Dell'Acqua A., Delle Rose L., Delmastro M., De Lucia E., Demarteau M., Denegri D., Deniau L., Denisov D., Denizli H., Denner A., d'Enterria D., de Rijk G., De Roeck A., Derue F., Deschamps O., Descotes-Genon S., Dev P.S.B., de Vivie de Regie J.B., Dewanjee R.K., Di Ciaccio A., Di Cicco A., Dillon B.M., Di Micco B., Di Nezza P., Di Vita S., Doblhammer A., Dominjon A., D'Onofrio M., Dordei F., Drago A., Draper P., Drasal Z., Drewes M., Duarte L., Dubovyk I., Duda P., Dudarev A., Dudko L., Duellmann D., Dunser M., du Pree T., Durante M., Duran Yildiz H., Dutta S., Duval F., Duval J.M., Dydyshka Y., Dziewit B., Eisenhardt S., Eisterer M., Ekelof T., El Khechen D., Ellis S.A., Ellis J., Ellison J.A., Elsener K., Elsing M., Enari Y., Englert C., Eriksson H., Eskola K.J., Esposito L.S., Etisken O., Etzion E., Fabbricatore P., Falkowski A., Falou A., Faltova J., Fan J., Fano L., Farilla A., Farinelli R., Farinon S., Faroughy D.A., Fartoukh S.D., Faus-Golfe A., Fawcett W.J., Felici G., Felsberger L., Ferdeghini C., Fernandez Navarro A.M., Fernandez-Tellez A., Ferradas Troitino J., Ferrara G., Ferrari R., Ferreira L., Ferreira da Silva P., Ferrera G., Ferro F., Fiascaris M., Fiorendi S., Fiorio C., Fischer O., Fischer E., Flieger W., Florio M., Fonnesu D., Fontanesi E., Foppiani N., Foraz K., Forkel-Wirth D., Forte S., Fouaidy M., Fournier D., Fowler T., Fox J., Francavilla P., Franceschini R., Franchino S., Franco E., Freitas A., Fuks B., Furukawa K., Furuseth S.V., Gabrielli E., Gaddi A., Galanti M., Gallo E., Ganjour S., Gao J., Garcia Diaz V., Garcia Perez M., Garcia Tabares L., Garion C., Garzelli M.V., Garzia I., Gascon-Shotkin S.M., Gaudio G., Gay P., Ge S.-F., Gehrmann T., Genest M.H., Gerard R., Gerigk F., Gerwig H., Giacomelli P., Giagu S., Gianfelice-Wendt E., Gianotti F., Giffoni F., Gilardoni S.S., Gil Costa M., Giovannetti M., Giovannozzi M., Giubellino P., Giudice G.F., Giunta A., Gladilin L.K., Glukhov S., Gluza J., Gobbi G., Goddard B., Goertz F., Golling T., Goncalves V.P., Goncalo R., Gonzalez Gomez L.A., Gorgi Zadeh S., Gorine G., Gorini E., Gourlay S.A., Gouskos L., Grancagnolo F., Grassellino A., Grau A., Graverini E., Gray H.M., Greco M., Grenard J.-L., Grimm O., Grojean C., Gromov V.A., Grosse-Oetringhaus J.F., Grudiev A., Grzanka K., Gu J., Guadagnoli D., Guidi V., Guiducci S., Guillermo Canton G., Gunaydin Y.O., Gupta R., Gupta R.S., Gutierrez J., Gutleber J., Guyot C., Guzey V., Gwenlan C., Haberstroh C., Hacisahinoglu B., Haerer B., Hahn K., Hahn T., Hammad A., Han C., Hance M., Hannah A., Harris P.C., Hati C., Haug S., Hauptman J., Haurylavets V., He H.-J., Hegglin A., Hegner B., Heinemann K., Heinemeyer S., Helsens C., Henriques A., Hernandez P., Hernandez-Pinto R.J., Hernandez-Sanchez J., Herzig T., Hiekkanen I., Hillert W., Hoehn T., Hofer M., Hofle W., Holdener F., Holleis S., Holzer B., Hong D.K., Honorato C.G., Hopkins S.C., Hrdinka J., Hug F., Humann B., Humer H., Hurth T., Hutton A., Iacobucci G., Ibarrola N., Iconomidou-Fayard L., Ilyina-Brunner K., Incandela J., Infantino A., Ippolito V., Ishino M., Islam R., Ita H., Ivanovs A., Iwamoto S., Iyer A., Izquierdo Bermudez S., Jadach S., Jamin D.O., Janot P., Jarry P., Jeff A., Jenny P., Jensen E., Jensen M., Jiang X., Jimenez J.M., Jones M.A., Jones O.R., Jowett J.M., Jung S., Kaabi W., Kado M., Kahle K., Kalinovskaya L., Kalinowski J., Kamenik J.F., Kannike K., Kara S.O., Karadeniz H., Karaventzas V., Karpov I., Kartal S., Karyukhin A., Kashikhin V., Katharina Behr J., Kaya U., Keintzel J., Keinz P.A., Keppel K., Kersevan R., Kershaw K., Khanpour H., Khatibi S., Khatiri Yanehsari M., Khoze V.V., Kieseler J., Kilic A., Kilpinen A., Kim Y.-K., Kim D.W., Klein U., Klein M., Kling F., Klinkenberg N., Kloppel S., Klute M., Klyukhin V.I., Knecht M., Kniehl B., Kocak F., Koeberl C., Kolano A.M., Kollegger A., Kolodziej K., Kolomiets A.A., Komppula J., Koop I., Koppenburg P., Koratzinos M., Kordiaczynska M., Korjik M., Kortner O., Kostka P., Kotlarski W., Kotnig C., Kottig T., Kotwal A.V., Kovalenko A.D., Kowalski S., Kozaczuk J., Kozlov G.A., Kozub S.S., Krainer A.M., Kramer T., Kramer M., Krammer M., Krasnov A.A., Krauss F., Kravalis K., Kretzschmar L., Kriske R.M., Kritscher H., Krkotic P., Kroha H., Kucharczyk M., Kuday S., Kuendig A., Kuhlmann G., Kulesza A., Kumar M., Kusina A., Kuttimalai S., Kuze M., Kwon T., Lackner F., Lackner M., La Francesca E., Laine M., Lamanna G., La Mendola S., Lancon E., Landsberg G., Langacker P., Lange C., Langner A., Lankford A.J., Lansberg J.P., Lari T., Laycock P.J., Lebrun P., Lechner A., Lee K., Lee S., Lee R., Lefevre T., Le Guen P., Lehtinen T., Leith S.B., Lenzi P., Leogrande E., Leonidopoulos C., Leon-Monzon I., Lerner G., Leroy O., Lesiak T., Levai P., Leveratto A., Levichev E., Li G., Li S., Li R., Liberati D., Liepe M., Lissauer D.A., Liu Z., Lobko A., Locci E., Logothetis Agaliotis E., Lombardo M.P., Long A.J., Lorin C., Losito R., Louzguiti A., Low I., Lucchesi D., Lucchini M.T., Luciani A., Lueckhof M., Lunt A.J.G., Luzum M., Lyubimtsev D.A., Maggiora M., Magnin N., Mahmoud M.A., Mahmoudi F., Maitre J., Makarenko V., Malagoli A., Malcles J., Malgeri L., Mallon P.J., Maltoni F., Malvezzi S., Malyshev O.B., Mancinelli G., Mandrik P., Manfrinetti P., Mangano M., Manil P., Mannelli M., Marchiori G., Marhauser F., Mariani V., Marinozzi V., Mariotto S., Marquard P., Marquet C., Marriott-Dodington T., Martin R., Martin O., Martin Camalich J., Martinez T., Martinez Bruzual H., Martinez-Hernandez M.I., Martins D.E., Marzani S., Marzocca D., Marzola L., Masciocchi S., Masina I., Massimiliano A., Massironi A., Masubuchi T., Matveev V.A., Mazzoni M.A., McCullough M., McIntosh P.A., Meade P., Medina L., Meier A., Meignan J., Mele B., Mendes Saraiva J.G., Menez F., Mentink M., Meoni E., Meridiani P., Merk M., Mermod P., Mertens V., Mether L., Metral E., Migliorati M., Milanese A., Milardi C., Milhano G., Militsyn B.L., Millet F., Minashvili I., Minervini J.V., Miralles L.S., Mirarchi D., Mishima S., Missiaen D.P., Mitselmakher G., Mitshuhashi T., Mnich J., Mohammadi Najafabadi M., Mohapatra R.N., Mokhov N., Molson J.G., Monge R., Montag C., Montagna G., Monteil S., Montenero G., Montesinos E., Moortgat F., Morange N., Morello G., Moreno Llacer M., Moretti M., Moretti S., Morley A.K., Moros A., Morozov I., Morretta V., Morrone M., Mostacci A., Muanza S., Muchnoi N., Muhlegger M., Mulder M., Mulders M., Muller B., Muller F., Muller A.-S., Munilla J., Murray M.J., Muttoni Y., Myers S., Mylona M., Nachtman J., Nakamoto T., Nardecchia M., Nardini G., Nason P., Nergiz Z., Nesterenko A.V., Netto J.A., Nettstrater A., Neubuser C., Neundorf J., Niccoli F., Nicrosini O., Nie Y., Niedermayer U., Niedziela J., Niemi A., Nikitin S.A., Nisati A., No J.M., Nonis M., Nosochkov Y., Novak M., Novokhatski A., O'Callaghan J.M., Ochando C., Ogur S., Ohmi K., Oide K., Okorokov V.A., Okumura Y., Oleari C., Olness F.I., Onel Y., Ortino M., Osborne J., Osland P., Otto T., Oyulmaz K.Y., Ozansoy A., Ozcan V., Ozdemir K., Pagliarone C.E., Pais da Silva H.F., Palmieri E., Palumbo L., Pampaloni A., Pan R.-Q., Panareo M., Panella O., Panico G., Panizzo G., Pankov A.A., Pantsyrny V., Papadopoulos C.G., Papaefstathiou A., Papaphilippou Y., Parker M.A., Parma V., Pasquali M., Patra S.K., Patterson R., Paukkunen H., Pauss F., Peggs S., Penttinen J.-P., Peon G., Perepelkin E.E., Perez E., Perez J.C., Perez G., Perez F., Perez Codina E., Perez Morales J., Perfilov M., Pernegger H., Peruzzi M., Pes C., Peters K., Petracca S., Petriello F., Pezzotti L., Pfeiffer S., Piccinini F., Pieloni T., Pierini M., Pikhartova H., Pikurs G., Pilicer E., Piminov P., Pira C., Pittau R., Placzek W., Plagge M., Plehn T., Pleier M.-A., Ploskon M., Podeur M., Podlech H., Podzorny T., Poggioli L., Poiron A., Polesello G., Poli Lener M., Polini A., Polinski J., Polozov S.M., Ponce L., Pont M., Pontecorvo L., Portaluri T., Potamianos K., Prasse C., Prausa M., Preinerstorfer A., Premat E., Price T., Primavera M., Prino F., Prioli M., Proudfoot J., Provino A., Pugnat T., Pukhaeva N., Pulawski S., Pulikowski D., Punzi G., Putti M., Pyarelal A., Quack H., Quispe M., Racioppi A., Rafique H., Raginel V., Raidal M., Ramirez-Uribe N.S., Ramsey-Musolf M.J., Rata R., Ratoff P., Ravotti F., Rebello Teles P., Reboud M., Redaelli S., Renner E., Renteria-Olivo A.E., Rescigno M., Reuter J., Ribon A., Ricci A.M., Riegler W., Riemann S., Riemann B., Riemann T., Rifflet J.M., Rimmer R.A., Rinaldesi R., Rinolfi L., Rios Rubiras O., Risselada T., Rivetti A., Rivkin L., Rizzo T., Robens T., Robert F., Robson A.J., Rochepault E., Roda C., Rodrigo G., Rodriguez-Cahuantzi M., Rogan C., Roig M., Rojas-Torres S., Rojo J., Rolandi G., Rolando G., Roloff P., Romanenko A., Romanov A., Roncarolo F., Rosado Sanchez A., Rosaz G., Rossi L., Rossi A., Rossmanith R., Rousset B., Royon C., Ruan X., Ruehl I., Ruhlmann-Kleider V., Ruiz R., Rumyantsev L., Ruprecht R., Ryazanov A.I., Saba A., Sadykov R., Saez de Jauregui D., Sahin M., Sailer B., Saito M., Sala F., Salam G.P., Salfeld-Nebgen J., Salgado C.A., Salini S., Sallese J.M., Salmi T., Salzburger A., Sampayo O.A., Sanfilippo S., Santiago J., Santopinto E., Santoro R., Sanz Ull A., Sarasola X., Sarpun I.H., Sauvain M., Savelyeva S., Sawada R., Sborlini G.F.R., Schaffer A., Schaumann M., Schenk M., Scheuerlein C., Schienbein I., Schlenga K., Schmickler H., Schmidt R., Schoerling D., Schoning A., Schorner-Sadenius T., Schott M., Schulte D., Schwaller P., Schwanenberger C., Schwemling P., Schwerg N., Scibile L., Sciuto A., Scomparin E., Sebastiani C., Seeber B., Segreti M., Selva P., Selvaggi M., Senatore C., Senol A., Serin L., Serluca M., Serra N., Seryi A., Sestini L., Sfyrla A., Shaposhnikov M., Shaposhnikova E., Sharkov B.Y., Shatilov D., Shelton J., Shiltsev V., Shipsey I.P., Shirkov G.D., Shivaji A., Shwartz D., Sian T., Sidorov S., Siemko A., Silvestrini L., Simand N., Simon F., Singh B.K., Siodmok A., Sirois Y., Sirtori E., Sirvinskaite R., Sitar B., Sjostrand T., Skands P., Skordis E., Skovpen K., Skrzypek M., Slade E., Slavich P., Slovak R., Smaluk V., Smirnov V., Snoeys W., Soffi L., Sollander P., Solovyanov O., Soltveit H.K., Song H., Sopicki P., Sorbi M., Spallino L., Spannowsky M., Spataro B., Sphicas P., Spiesberger H., Spiller P., Spira M., Srivastava T., Stachel J., Stakia A., Stanyard J.L., Starchenko E., Starikov A.Y., Stasto A.M., Statera M., Steerenberg R., Steggemann J., Stenvall A., Stivanello F., Stockinger D., Stoel L.S., Stoger-Pollach M., Strauss B., Stuart M., Stupakov G., Su S., Sublet A., Sugita K., Sulak L., Sullivan M.K., Sultansoy S., Sumida T., Suzuki K., Sylva G., Syphers M.J., Sznajder A., Taborelli M., Tahir N.A., Takeuchi M., Tal Hod E., Tambasco C., Tanaka J., Tang K., Tapan I., Taroni S., Tartarelli G.F., Tassielli G., Tavian L., Taylor T.M., Taylor G.N., Teixeira A.M., Tejeda-Munoz G., Telnov V.I., Tenchini R., ten Kate H.H.J., Terashi K., Tesi A., Testa M., Tetrel C., Teytelman D., Thaler J., Thamm A., Thomas S., Tiirakari M.T., Tikhomirov V., Tikhonov D., Timko H., Tisserand V., Tkachenko L.M., Tkaczuk J., Tock J.P., Todd B., Todesco E., Tomas Garcia R., Tommasini D., Tonelli G., Toral F., Torims T., Torre R., Townsend Z., Trant R., Treille D., Trentadue L., Tricoli A., Tricomi A., Trischuk W., Tropin I.S., Tuchming B., Tudora A.A., Turbiarz B., Turk Cakir I., Turri M., Tydecks T., Usovitsch J., Uythoven J., Vaglio R., Valassi A., Valchkova F., Valdivia Garcia M.A., Valente P., Valente R.U., Valente-Feliciano A.-M., Valentino G., Vale Silva L., Valet J.M., Valizadeh R., Valle J.W.F., Vallecorsa S., Vallone G., van Leeuwen M., van Rienen U.H., van Riesen-Haupt L., Varasteh M., Vecchi L., Vedrine P., Velev G., Veness R., Ventura A., Venturini Delsolaro W., Verducci M., Verhaaren C.B., Vernieri C., Verweij A.P., Verwilligen O., Viazlo O., Vicini A., Viehhauser G., Vignaroli N., Vignolo M., Vitrano A., Vivarelli I., Vlachos S., Vogel M., Vogt D.M., Volkl V., Volkov P., Volpini G., von Ahnen J., Vorotnikov G., Voutsinas G.G., Vysotsky V., Wagner U., Wallny R., Wang L.-T., Wang R., Wang K., Ward B.F.L., Watson T.P., Watson N.K., Ws Z., Weiland C., Weinzierl S., Welsch C.P., Wenninger J., Widorski M., Wiedemann U.A., Wienands H.-U., Wilkinson G., Williams P.H., Winter A., Wohlfahrt A., Wojton T., Wollmann D., Womersley J., Woog D., Wu X., Wulzer A., Yanehsari M.K., Yang G., Yang H.J., Yao W.-M., Yazgan E., Yermolchik V., Yilmaz A., Yoo H.-D., Yost S.A., You T., Young C., Yu T.-T., Yu F., Zaborowska A., Zadeh S.G., Zahnd M., Zanetti M., Zanotto L., Zawiejski L., Zeiler P., Zerlauth M., Zernov S.M., Zevi Dell Porta G., Zhang Z., Zhang Y., Zhang C., Zhang H., Zhao Z., Zhong Y.-M., Zhou J., Zhou D., Zhuang P., Zick G., Zimmermann F., Zinn-Justin J., Zivkovic L., Zlobin A.V., Zobov M., Zupan J., Zurita J., BAİBÜ, Fen Edebiyat Fakültesi, Fizik Bölümü, Denizli, Haluk, TOBB ETU, Faculty of Engineering, Department of Electrical & Electronics Engineering, TOBB ETU, Faculty of Engineering, Department of Material Science & Nanotechnology Engineering, TOBB ETÜ, Mühendislik Fakültesi, Elektrik ve Elektronik Mühendisliği Bölümü, TOBB ETÜ, Mühendislik Fakültesi, Malzeme Bilimi ve Nanoteknoloji Mühendisliği Bölümü, Bozbey, Ali, Sultansoy, Saleh, Özdemir, Kadri, Giresun Üniversitesi, UCL - SST/IRMP - Institut de recherche en mathématique et physique, and Ege Üniversitesi

Subjects
Beam losses, IMPACT, Physics::Instrumentation and Detectors, Physics beyond the Standard Model, EVENT BUILDER, hadron collider, General Physics and Astronomy, Mathematics and natural science: 400::Physics: 430::Nuclear and elementary particle physics: 431 [VDP], 01 natural sciences, 7. Clean energy, law.invention, Subatomär fysik, chemistry.chemical_compound, Conceptual design, Colliding beam accelerators, law, HE-LHC, Subatomic Physics, General Materials Science, Hadron colliders, Física::Física de partícules::Hadrons [Àrees temàtiques de la UPC], Large Hadron Collider, Acceleradors de partícules, Physics, Settore FIS/01 - Fisica Sperimentale, Beams (radiation), Settore FIS/02 - Fisica Teorica, Modelli e Metodi Matematici, Upgrade, Impact, collimators, partikkelfysikk, Future Circular Collider, High-Energy, Systems engineering, HE-LHC: The High-Energy Large Hadron Collider, Col·lisionadors d'hadrons, Applied physics, Collimators, Socio-culturale, Fizik, Hadrons, Accelerator Physics and Instrumentation, HE-LHC physics, Condensed Matter::Materials Science, 0103 physical sciences, Physics::Atomic and Molecular Clusters, beam losses, ddc:530, High Energy Physics, partikkelakselerator, Physical and Theoretical Chemistry, Niobium-tin, 010306 general physics, Collider, Particle Physics, Beams (radiation) | Collimators | Beam losses, Energies::Energia nuclear [Àrees temàtiques de la UPC], Large Hadron Collider HE-LHC, 010308 nuclear & particles physics, High Energy Physics::Phenomenology, Colliders (Nuclear physics), Acceleratorfysik och instrumentering, Event builder, Accelerators and Storage Rings, Particle accelerators, chemistry, Experimental High Energy Physics, Physics::Accelerator Physics, High Energy Physics::Experiment, Future Colliders
Abstract

Authors: A. AbadaM. AbbresciaS. S. AbdusSalamI. AbdyukhanovJ. Abelleira FernandezA. AbramovM. AburaiaA. O. AcarP. R. AdzicP. AgrawalJ. A. Aguilar-SaavedraJ. J. Aguilera-VerdugoM. AibaI. AichingerG. AielliA. AkayA. AkhundovH. AksakalJ. L. AlbaceteS. AlbergoA. AlekouM. AleksaR. AleksanR. M. Alemany FernandezY. AlexahinR. G. AlíaS. AlioliN. Alipour TehraniB. C. AllanachP. P. AllportM. AltınlıW. AltmannshoferG. AmbrosioD. AmorimO. AmstutzL. AnderliniA. AndreazzaM. AndreiniA. AndriatisC. AndrisA. AndronicM. AngelucciF. AntinoriS. A. AntipovM. AntonelliM. AntonelloP. AntonioliS. AntuschF. AnulliL. ApolinárioG. ApollinariA. ApollonioD. AppelöR. B. ApplebyA. ApyanA. ApyanA. ArbeyA. ArbuzovG. ArduiniV. ArıS. AriasN. ArmestoR. ArnaldiS. A. ArsenyevM. ArzeoS. AsaiE. AslanidesR. W. AßmannD. AstapovychM. AtanasovS. AtiehD. AttiéB. AuchmannA. AudurierS. AullS. AumonS. AuneF. AvinoG. AvrillaudG. AydınA. AzatovG. AzuelosP. AzziO. AzzoliniP. AzzurriN. BacchettaE. BacchiocchiH. BachacouY. W. BaekV. BaglinY. BaiS. BairdM. J. BakerM. J. BaldwinA. H. BallA. BallarinoS. BanerjeeD. P. BarberD. BarducciP. BarjhouxD. BarnaG. G. BarnaföldiM. J. BarnesA. BarrJ. Barranco GarcíaJ. Barreiro Guimarães da CostaW. BartmannV. BaryshevskyE. BarziS. A. BassA. BastianinB. BaudouyF. BauerM. BauerT. BaumgartnerI. Bautista-GuzmánC. BayındırF. BeaudetteF. BedeschiM. BéguinI. BellafontL. BellagambaN. BellegardeE. BelliE. BellingeriF. BelliniG. BellomoS. BelomestnykhG. BencivenniM. BenediktG. BernardiJ. BernardiC. BernetJ. M. BernhardtC. BerniniC. BerriaudA. BertarelliS. BertolucciM. I. BesanaM. BesançonO. BeznosovP. BhatC. BhatM. E. BiaginiJ. -L. BiarrotteA. Bibet ChevalierE. R. BielertM. BigliettiG. M. BileiB. BilkiC. BiscariF. BisharaO. R. Blanco-GarcíaF. R. BlánquezF. BlekmanA. BlondelJ. BlümleinT. BoccaliR. BoelsS. A. BogaczA. BogomyagkovO. Boine-FrankenheimM. J. BolandS. BolognaO. BolukbasiM. BombenS. BondarenkoM. BonviniE. BoosB. BordiniF. BordryG. BorghelloL. BorgonoviS. BorowkaD. BortolettoD. BoscheriniM. BoscoloS. BoselliR. R. BosleyF. BossuC. BottaL. BotturaR. BoughezalD. BoutinG. BovoneI. Božović JelisavićA. BozbeyC. BozziD. BozziniV. BracciniS. Braibant-GiacomelliJ. BramanteP. Braun-MunzingerJ. A. BriffaD. BritzgerS. J. BrodskyJ. J. BrookeR. BruceP. Brückman De RenstromE. BrunaO. BrüningO. BrunnerK. BrunnerP. BruzzoneX. BuffatE. BulyakF. BurkartH. BurkhardtJ. -P. BurnetF. ButinD. ButtazzoA. ButterworthM. CacciaY. CaiB. CaiffiV. CairoO. CakirR. CalagaS. CalatroniG. CalderiniG. CalderolaA. CaliskanD. CalvetM. CalvianiJ. M. CamalichP. CamarriM. CampanelliT. CamporesiA. C. CanbayA. CanepaE. CantergianiD. Cantore-CavalliM. CapeansR. CardarelliU. CardellaA. CardiniC. M. Carloni CalameF. CarraS. CarraA. CarvalhoS. CasalbuoniJ. CasasM. CascellaP. CastelnovoG. CastorinaG. CatalanoV. CavasinniE. CazzatoE. CenniniA. CerriF. CeruttiJ. CervantesI. ChaikovskaJ. ChakraborttyM. ChalaM. Chamizo-LlatasH. ChanalD. ChanalS. ChanceA. ChancéP. CharitosJ. CharlesT. K. CharlesS. ChattopadhyayR. ChehabS. V. ChekanovN. ChenA. ChernodedV. ChetvertkovaL. ChevalierG. ChiarelliG. ChiarelloM. ChiesaP. ChiggiatoJ. T. ChildersA. ChmielińskaA. CholakianP. ChomazM. ChorowskiW. ChouM. ChrzaszczE. ChyhyrynetsG. CibinettoA. K. CiftciR. CiftciR. CiminoM. CiuchiniP. J. ClarkY. CoadouM. CobalA. CoccaroJ. CoganE. CognerasF. CollamatiC. ColldelramP. CollierJ. CollotR. ContinoF. ConventiC. T. A. CookL. CooleyG. CorcellaA. S. CornellG. H. CorralH. Correia-RodriguesF. CostanzaP. Costa PintoF. CoudercJ. CoupardN. CraigI. Crespo GarridoA. CrivellinJ. F. CroteauM. CrouchE. Cruz AlanizB. CuréJ. CurtiD. CurtinM. CzechC. DachauerR. T. D’AgnoloM. DaiboA. DaineseB. DalenaA. DaljevecW. DallapiazzaL. D’Aloia SchwartzentruberM. DamG. D’AmbrosioS. P. DasS. DasBakshiW. da SilvaG. G. da SilveiraV. D’AuriaS. D’AuriaA. DavidT. DavidekA. DeandreaJ. de BlasC. J. DebonoS. De CurtisN. De FilippisD. de FlorianS. DeghayeS. J. de JongC. Del BoV. Del DucaD. DelikarisF. DeliotA. Dell’AcquaL. Delle RoseM. DelmastroE. De LuciaM. DemarteauD. DenegriL. DeniauD. DenisovH. DenizliA. DennerD. d’EnterriaG. de RijkA. De RoeckF. DerueO. DeschampsS. Descotes-GenonP. S. B. DevJ. B. de Vivie de RégieR. K. DewanjeeA. Di CiaccioA. Di CiccoB. M. DillonB. Di MiccoP. Di NezzaS. Di VitaA. DoblhammerA. DominjonM. D’OnofrioF. DordeiA. DragoP. DraperZ. DrasalM. DrewesL. DuarteI. DubovykP. DudaA. DudarevL. DudkoD. DuellmannM. DünserT. du PreeM. DuranteH. Duran YildizS. DuttaF. DuvalJ. M. DuvalY. DydyshkaB. DziewitS. EisenhardtM. EistererT. EkelofD. El KhechenS. A. EllisJ. EllisJ. A. EllisonK. ElsenerM. ElsingY. EnariC. EnglertH. ErikssonK. J. EskolaL. S. EspositoO. EtiskenE. EtzionP. FabbricatoreA. FalkowskiA. FalouJ. FaltovaJ. FanL. FanòA. FarillaR. FarinelliS. FarinonD. A. FaroughyS. D. FartoukhA. Faus-GolfeW. J. FawcettG. FeliciL. FelsbergerC. FerdeghiniA. M. Fernandez NavarroA. Fernández-TéllezJ. Ferradas TroitinoG. FerraraR. FerrariL. FerreiraP. Ferreira da SilvaG. FerreraF. FerroM. FiascarisS. FiorendiC. FiorioO. FischerE. FischerW. FliegerM. FlorioD. FonnesuE. FontanesiN. FoppianiK. ForazD. Forkel-WirthS. ForteM. FouaidyD. FournierT. FowlerJ. FoxP. FrancavillaR. FranceschiniS. FranchinoE. FrancoA. FreitasB. FuksK. FurukawaS. V. FurusethE. GabrielliA. GaddiM. GalantiE. GalloS. GanjourJ. GaoJ. GaoV. Garcia DiazM. García PérezL. García TabarésC. GarionM. V. GarzelliI. GarziaS. M. Gascon-ShotkinG. GaudioP. GayS. -F. GeT. GehrmannM. H. GenestR. GerardF. GerigkH. GerwigP. GiacomelliS. GiaguE. Gianfelice-WendtF. GianottiF. GiffoniS. S. GilardoniM. Gil CostaM. GiovannettiM. GiovannozziP. GiubellinoG. F. GiudiceA. GiuntaL. K. GladilinS. GlukhovJ. GluzaG. GobbiB. GoddardF. GoertzT. GollingV. P. GoncalvesR. GonçaloL. A. Gonzalez GomezS. Gorgi ZadehG. GorineE. GoriniS. A. GourlayL. GouskosF. GrancagnoloA. GrassellinoA. GrauE. GraveriniH. M. GrayMa. GrecoMi. GrecoJ. -L. GrenardO. GrimmC. GrojeanV. A. GromovJ. F. Grosse-OetringhausA. GrudievK. GrzankaJ. GuD. GuadagnoliV. GuidiS. GuiducciG. Guillermo CantonY. O. GünaydinR. GuptaR. S. GuptaJ. GutierrezJ. GutleberC. GuyotV. GuzeyC. GwenlanC. HaberstrohB. HacışahinoğluB. HaererK. HahnT. HahnA. HammadC. HanM. HanceA. HannahP. C. HarrisC. HatiS. HaugJ. HauptmanV. HaurylavetsH. -J. HeA. HegglinB. HegnerK. HeinemannS. HeinemeyerC. HelsensA. HenriquesA. HenriquesP. HernandezR. J. Hernández-PintoJ. Hernandez-SanchezT. HerzigI. HiekkanenW. HillertT. HoehnM. HoferW. HöfleF. HoldenerS. HolleisB. HolzerD. K. HongC. G. HonoratoS. C. HopkinsJ. HrdinkaF. HugB. HumannH. HumerT. HurthA. HuttonG. IacobucciN. IbarrolaL. Iconomidou-FayardK. Ilyina-BrunnerJ. IncandelaA. InfantinoV. IppolitoM. IshinoR. IslamH. ItaA. IvanovsS. IwamotoA. IyerS. Izquierdo BermudezS. JadachD. O. JaminP. JanotP. JarryA. JeffP. JennyE. JensenM. JensenX. JiangJ. M. JiménezM. A. JonesO. R. JonesJ. M. JowettS. JungW. KaabiM. KadoK. KahleL. KalinovskayaJ. KalinowskiJ. F. KamenikK. KannikeS. O. KaraH. KaradenizV. KaraventzasI. KarpovS. KartalA. KaryukhinV. KashikhinJ. Katharina BehrU. KayaJ. KeintzelP. A. KeinzK. KeppelR. KersevanK. KershawH. KhanpourS. KhatibiM. Khatiri YanehsariV. V. KhozeJ. KieselerA. KilicA. KilpinenY. -K. KimD. W. KimU. KleinM. KleinF. KlingN. KlinkenbergS. KlöppelM. KluteV. I. KlyukhinM. KnechtB. KniehlF. KocakC. KoeberlA. M. KolanoA. KolleggerK. KołodziejA. A. KolomietsJ. KomppulaI. KoopP. KoppenburgM. KoratzinosM. KordiaczyńskaM. KorjikO. KortnerP. KostkaW. KotlarskiC. KotnigT. KöttigA. V. KotwalA. D. KovalenkoS. KowalskiJ. KozaczukG. A. KozlovS. S. KozubA. M. KrainerT. KramerM. KrämerM. KrammerA. A. KrasnovF. KraussK. KravalisL. KretzschmarR. M. KriskeH. KritscherP. KrkoticH. KrohaM. KucharczykS. KudayA. KuendigG. KuhlmannA. KuleszaM. KumarM. KumarA. KusinaS. KuttimalaiM. KuzeT. KwonF. LacknerM. LacknerE. La FrancescaM. LaineG. LamannaS. La MendolaE. LançonG. LandsbergP. LangackerC. LangeA. LangnerA. J. LankfordJ. P. LansbergT. LariP. J. LaycockP. LebrunA. LechnerK. LeeS. LeeR. LeeT. LefevreP. Le GuenT. LehtinenS. B. LeithP. LenziE. LeograndeC. LeonidopoulosI. Leon-MonzonG. LernerO. LeroyT. LesiakP. LévaiA. LeverattoE. LevichevG. LiS. LiR. LiD. LiberatiM. LiepeD. A. LissauerZ. LiuA. LobkoE. LocciE. Logothetis AgaliotisM. P. LombardoA. J. LongC. LorinR. LositoA. LouzguitiI. LowD. LucchesiM. T. LucchiniA. LucianiM. LueckhofA. J. G. LuntM. LuzumD. A. LyubimtsevM. MaggioraN. MagninM. A. MahmoudF. MahmoudiJ. MaitreV. MakarenkoA. MalagoliJ. MalclésL. MalgeriP. J. MallonF. MaltoniS. MalvezziO. B. MalyshevG. MancinelliP. MandrikP. ManfrinettiM. ManganoP. ManilM. MannelliG. MarchioriF. MarhauserV. MarianiV. MarinozziS. MariottoP. MarquardC. MarquetT. Marriott-DodingtonR. MartinO. MartinJ. Martin CamalichT. MartinezH. Martinez BruzualM. I. Martínez-HernándezD. E. MartinsS. MarzaniD. MarzoccaL. MarzolaS. MasciocchiI. MasinaA. MassimilianoA. MassironiT. MasubuchiV. A. MatveevM. A. MazzoniM. McCulloughP. A. McIntoshP. MeadeL. MedinaA. MeierJ. MeignanB. MeleJ. G. Mendes SaraivaF. MenezM. MentinkE. MeoniP. MeridianiM. MerkP. MermodV. MertensL. MetherE. MétralM. MiglioratiA. MilaneseC. MilardiG. MilhanoB. L. MilitsynF. MilletI. MinashviliJ. V. MinerviniL. S. MirallesD. MirarchiS. MishimaD. P. MissiaenG. MitselmakherT. MitshuhashiJ. MnichM. Mohammadi NajafabadiR. N. MohapatraN. MokhovJ. G. MolsonR. MongeC. MontagG. MontagnaS. MonteilG. MonteneroE. MontesinosF. MoortgatN. MorangeG. MorelloM. Moreno LlácerM. MorettiS. MorettiA. K. MorleyA. MorosI. MorozovV. MorrettaM. MorroneA. MostacciS. MuanzaN. MuchnoiM. MühleggerM. MulderM. MuldersB. MüllerF. MüllerA. -S. MüllerJ. MunillaM. J. MurrayY. MuttoniS. MyersM. MylonaJ. NachtmanT. NakamotoM. NardecchiaG. NardiniP. NasonZ. NergizA. V. NesterenkoJ. A. NettoA. NettsträterC. NeubüserJ. NeundorfF. NiccoliO. NicrosiniY. NieU. NiedermayerJ. NiedzielaA. NiemiS. A. NikitinA. NisatiJ. M. NoM. NonisY. NosochkovM. NovákA. NovokhatskiJ. M. O’CallaghanC. OchandoS. OgurK. OhmiK. OideV. A. OkorokovY. OkumuraC. OleariF. I. OlnessY. OnelM. OrtinoJ. OsborneP. OslandT. OttoK. Y. OyulmazA. OzansoyV. ÖzcanK. ÖzdemirC. E. PagliaroneH. F. Pais da SilvaE. PalmieriL. PalumboA. PampaloniR. -Q. PanM. PanareoO. PanellaG. PanicoG. PanizzoA. A. PankovV. PantsyrnyC. G. PapadopoulosA. PapaefstathiouY. PapaphilippouM. A. ParkerV. ParmaM. PasqualiS. K. PatraR. PattersonH. PaukkunenF. PaussS. PeggsJ. -P. PenttinenG. PeónE. E. PerepelkinE. PerezJ. C. PerezG. PerezF. PérezE. Perez CodinaJ. Perez MoralesM. PerfilovH. PerneggerM. PeruzziC. PesK. PetersS. PetraccaF. PetrielloL. PezzottiS. PfeifferF. PiccininiT. PieloniM. PieriniH. PikhartovaG. PikursE. PilicerP. PiminovC. PiraR. PittauW. PłaczekM. PlaggeT. PlehnM. -A. PleierM. PłoskońM. PodeurH. PodlechT. PodzornyL. PoggioliA. PoironG. PoleselloM. Poli LenerA. PoliniJ. PolinskiS. M. PolozovL. PonceM. PontL. PontecorvoT. PortaluriK. PotamianosC. PrasseM. PrausaA. PreinerstorferE. PrematT. PriceM. PrimaveraF. PrinoM. PrioliJ. ProudfootA. ProvinoT. PugnatN. PukhaevaS. PuławskiD. PulikowskiG. PunziM. PuttiA. PyarelalH. QuackM. QuispeA. RacioppiH. RafiqueV. RaginelM. RaidalN. S. Ramírez-UribeM. J. Ramsey-MusolfR. RataP. RatoffF. RavottiP. Rebello TelesM. ReboudS. RedaelliE. RennerA. E. Rentería-OlivoM. RescignoJ. ReuterA. RibonA. M. RicciW. RieglerS. RiemannB. RiemannT. RiemannJ. M. RiffletR. A. RimmerR. RinaldesiL. RinolfiO. Rios RubirasT. RisseladaA. RivettiL. RivkinT. RizzoT. RobensF. RobertA. J. RobsonE. RochepaultC. RodaG. RodrigoM. Rodríguez-CahuantziC. RoganM. RoigS. Rojas-TorresJ. RojoG. RolandiG. RolandoP. RoloffA. RomanenkoA. RomanovF. RoncaroloA. Rosado SanchezG. RosazL. RossiA. RossiR. RossmanithB. RoussetC. RoyonX. RuanI. RuehlV. Ruhlmann-KleiderR. RuizL. RumyantsevR. RuprechtA. I. RyazanovA. SabaR. SadykovD. Saez de JaureguiM. SahinB. SailerM. SaitoF. SalaG. P. SalamJ. Salfeld-NebgenC. A. SalgadoS. SaliniJ. M. SalleseT. SalmiA. SalzburgerO. A. SampayoS. SanfilippoJ. SantiagoE. SantopintoR. SantoroA. Sanz UllX. SarasolaI. H. SarpünM. SauvainS. SavelyevaR. SawadaG. F. R. SborliniA. SchafferM. SchaumannM. SchenkC. ScheuerleinI. SchienbeinK. SchlengaH. SchmicklerR. SchmidtD. SchoerlingA. SchoningT. Schörner-SadeniusM. SchottD. SchulteP. SchwallerC. SchwanenbergerP. SchwemlingN. SchwergL. ScibileA. SciutoE. ScomparinC. SebastianiB. SeeberM. SegretiP. SelvaM. SelvaggiC. SenatoreA. SenolL. SerinM. SerlucaN. SerraA. SeryiL. SestiniA. SfyrlaM. ShaposhnikovE. ShaposhnikovaB. Y. SharkovD. ShatilovJ. SheltonV. ShiltsevI. P. ShipseyG. D. ShirkovA. ShivajiD. ShwartzT. SianS. SidorovA. SiemkoL. SilvestriniN. SimandF. SimonB. K. SinghA. SiódmokY. SiroisE. SirtoriR. SirvinskaiteB. SitarT. SjöstrandP. SkandsE. SkordisK. SkovpenM. SkrzypekE. SladeP. SlavichR. SlovakV. SmalukV. SmirnovW. SnoeysL. SoffiP. SollanderO. SolovyanovH. K. SoltveitH. SongP. SopickiM. SorbiL. SpallinoM. SpannowskyB. SpataroP. SphicasH. SpiesbergerP. SpillerM. SpiraT. SrivastavaJ. StachelA. StakiaJ. L. StanyardE. StarchenkoA. Y. StarikovA. M. StaśtoM. StateraR. SteerenbergJ. SteggemannA. StenvallF. StivanelloD. StöckingerL. S. StoelM. Stöger-PollachB. StraussM. StuartG. StupakovS. SuA. SubletK. SugitaL. SulakM. K. SullivanS. SultansoyT. SumidaK. SuzukiG. SylvaM. J. SyphersA. SznajderM. TaborelliN. A. TahirM. TakeuchiE. Tal HodC. TambascoJ. TanakaK. TangI. TapanS. TaroniG. F. TartarelliG. TassielliL. TavianT. M. TaylorG. N. TaylorA. M. TeixeiraG. Tejeda-MuñozV. I. TelnovR. TenchiniH. H. J. ten KateK. TerashiA. TesiM. TestaC. TetrelD. TeytelmanJ. ThalerA. ThammS. ThomasM. T. TiirakariV. TikhomirovD. TikhonovH. TimkoV. TisserandL. M. TkachenkoJ. TkaczukJ. P. TockB. ToddE. TodescoR. Tomás GarciaD. TommasiniG. TonelliF. ToralT. TorimsR. TorreZ. TownsendR. TrantD. TreilleL. TrentadueA. TricoliA. TricomiW. TrischukI. S. TropinB. TuchmingA. A. TudoraB. TurbiarzI. Turk CakirM. TurriT. TydecksJ. UsovitschJ. UythovenR. VaglioA. ValassiF. ValchkovaM. A. Valdivia GarciaP. ValenteR. U. ValenteA. -M. Valente-FelicianoG. ValentinoL. Vale SilvaJ. M. ValetR. ValizadehJ. W. F. ValleS. VallecorsaG. ValloneM. van LeeuwenU. H. van RienenL. van Riesen-HauptM. VarastehL. VecchiP. VedrineG. VelevR. VenessA. VenturaW. Venturini DelsolaroM. VerducciC. B. VerhaarenC. VernieriA. P. VerweijO. VerwilligenO. ViazloA. ViciniG. ViehhauserN. VignaroliM. VignoloA. VitranoI. VivarelliS. VlachosM. VogelD. M. VogtV. VölklP. VolkovG. VolpiniJ. von AhnenG. VorotnikovG. G. VoutsinasV. VysotskyU. WagnerR. WallnyL. -T. WangR. WangK. WangB. F. L. WardT. P. WatsonN. K. WatsonZ. WsC. WeilandS. WeinzierlC. P. WelschJ. WenningerM. WidorskiU. A. WiedemannH. -U. WienandsG. WilkinsonP. H. WilliamsA. WinterA. WohlfahrtT. WojtońD. WollmannJ. WomersleyD. WoogX. WuA. WulzerM. K. YanehsariG. YangH. J. YangW. -M. YaoE. YazganV. YermolchikA. YilmazA. YilmazH. -D. YooS. A. YostT. YouC. YoungT. -T. YuF. YuA. ZaborowskaS. G. ZadehM. ZahndM. ZanettiL. ZanottoL. ZawiejskiP. ZeilerM. ZerlauthS. M. ZernovG. Zevi Dell PortaZ. ZhangY. ZhangC. ZhangH. ZhangZ. ZhaoY. -M. ZhongJ. ZhouD. ZhouP. ZhuangG. ZickF. ZimmermannEmail authorJ. Zinn-JustinL. ZivkovicA. V. ZlobinM. ZobovJ. ZupanJ. Zuritathe FCC Collaboration, In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the fourth volume of the FCC Conceptual Design Report, devoted to the High-Energy Large Hadron Collider HE-LHC. It summarizes the HE-LHC physics discovery opportunities, presents the HE-LHC accelerator design, performance reach, and operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the HE-LHC design aims at a hadron collider with about twice the centre-of-mass collision energy that the LHC can reach. Its performance aims at exploring physics beyond the Standard Model, signi cantly extending the LHC's direct and indirect sensitivity to new physics and discoveries.

Published
2020
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6. 4-HNE-INDUCED INNATE IMMUNE RESPONSES INFLUENCE ANTI-CARCINOGENESIS IN ROS-OVERPRODUCED MODEL MICE

Author

T. Ishii, Y. Yamamoto, N. Ishii, K. Sugita, Philip S. Hartman, S. Asari, and Kayo Yasuda

Subjects
Abstracts, Health (social science), Innate immune system, Innate lymphoid cell, Cancer research, medicine, Biology, Life-span and Life-course Studies, Carcinogenesis, medicine.disease_cause, Health Professions (miscellaneous)
Abstract

Mitochondrial reactive oxygen species (ROS) which are mainly generated as an uncoupled consequence of electron transport cause the cellular and organismal oxidative stress. It has been previously demonstrated that the excessive mitochondrial ROS production caused by mitochondrial complex II SDHC mutation results in premature death in C. elegans mev-1 mutant (G71E) and D. melanogaster mev-1-mimic transgenic flies (I71E), and excessive apoptosis and tumorigenesis in mouse embryonic fibroblast SDHC E69 cells (V69E) (M. Tsuda, et al. BBRC 2007, T. Ishii, et al. Cancer Res. 2005, N. Ishii, et al. Nature 1998).

Published
2017

7. Analysis of matrix metalloproteinase (MMP-8 and MMP-2) activity in gingival crevicular fluid from children with Down's syndrome

Author

T. Yamazaki-Kubota, Y. Sano, Kazuyuki Ishihara, Masashi Yakushiji, Meguru Miyamoto, Takuro Yonezu, M. Kusumoto, Katsuji Okuda, and K. Sugita

Subjects
Male, medicine.medical_specialty, Down syndrome, Pathology, Adolescent, Oral Hygiene Index, Aggregatibacter, Bleeding on probing, Colony Count, Microbial, Dental Plaque, Gingiva, Inflammation, Gingival Pocket, Matrix metalloproteinase, Gastroenterology, Aggregatibacter actinomycetemcomitans, Internal medicine, medicine, Humans, Periodontal Pocket, Child, Porphyromonas gingivalis, Periodontitis, biology, Gingival Crevicular Fluid, biology.organism_classification, medicine.disease, Matrix Metalloproteinase 8, Actinobacillus, Campylobacter rectus, Periodontics, Matrix Metalloproteinase 2, Female, medicine.symptom, Down Syndrome, Periodontal Index, Gingival Hemorrhage
Abstract

Yamazaki-Kubota T, Miyamoto M, Sano Y, Kusumoto M, Yonezu T, Sugita K, Okuda K, Yakushiji M, Ishihara K. Analysis of matrix metalloproteinase (MMP-8 and MMP-2) activity in gingival crevicular fluid from children with Down’s syndrome. J Periodont Res 2010; doi: 10.1111/j.1600-0765.2009.01214.x. © 2009 John Wiley & Sons A/S Background and Objective: High levels of colonization by periodontopathic bacteria and a high prevalence of chronic inflammatory periodontal disease have been reported in children with Down’s syndrome. Matrix metalloproteinases (MMPs) are mediators of extracellular matrix degradation and remodelling, and are deeply involved in the course of periodontal disease. To clarify the relationship between Down’s syndrome and periodontitis, we investigated levels of MMP-2 and MMP-8 in gingival crevicular fluid (GCF) and detection of periodontopathic bacteria from subgingival plaque. Material and Methods: Samples of GCF and plaque were isolated from central incisors. Levels of MMPs were evaluated by enzyme-linked immunosorbent assay, and periodontopathic bacteria were detected by polymerase chain reaction. Results: Levels of MMP-2 and MMP-8 in Down’s syndrome patients were higher than those in healthy control subjects. In the Down’s syndrome group, increases in these MMPs were observed in GCF from patients with an oral hygiene index score of

Published
2010

8. Microneurosurgical Atlas

Author

K. Sugita and K. Sugita

Subjects
Nervous system—Surgery, Neurology, Nervous system—Radiography
Abstract

With the Assistance of Kobayashi, S.

Published
2012

9. Ligation of VLA-4 on T cells stimulates tyrosine phosphorylation of a 105-kD protein

Author

Stuart F. Schlossman, Yoshihisa Nojima, K Sugita, Chikao Morimoto, and David M. Rothstein

Subjects
Antigens, Differentiation, T-Lymphocyte, CD3 Complex, T-Lymphocytes, Immunology, Receptors, Antigen, T-Cell, Protein tyrosine phosphatase, In Vitro Techniques, SH2 domain, Receptor tyrosine kinase, chemistry.chemical_compound, Cell surface receptor, Antigens, CD, Receptors, Very Late Antigen, Immunology and Allergy, Humans, Protein phosphorylation, Phosphotyrosine, biology, Integrin beta1, Receptor Aggregation, Tyrosine phosphorylation, Articles, Protein-Tyrosine Kinases, Phosphoproteins, Molecular biology, Fibronectins, Enzyme Activation, Molecular Weight, chemistry, biology.protein, Phosphorylation, Tyrosine, Platelet-derived growth factor receptor, Signal Transduction
Abstract

The VLA/integrins are a family of heterodimeric adhesion receptors shown to be involved in cell-to-cell and cell-to-extracellular matrix (ECM) interactions. Given recent evidence that VLA molecules can synergize with the CD3/T cell receptor (TCR) pathway to activate T cells, it is important to identify biochemical event(s) generated by these molecules. Here, we report that the engagement of VLA-4 on T cells with specific antibodies or its ligand activates protein-tyrosine kinase (PTK) activity as detected by antiphosphotyrosine immunoblotting. The crosslinking of VLA-beta 1 (CD29) with a specific monoclonal antibody (mAb) (anti-4B4) plus anti-mouse immunoglobulin resulted in the rapid tyrosine phosphorylation of a 105-kD protein (pp105) in the human T cell line H9, as well as in peripheral resting T cells. The increase in tyrosine phosphorylation of pp105 was specifically mediated by VLA-4, since mAbs against alpha 4, but not against other VLA alpha chains, could induce this phosphorylation. In addition, the binding of T cells with the CS1 alternatively spliced segment of fibronectin (the binding site recognized by VLA-4) induced pp105 tyrosine phosphorylation. Crosslinking the CD3 complex or VLA-4 molecules with mAbs demonstrated that each of these molecules stimulated the tyrosine phosphorylation of unique sets of proteins with different kinetics, suggesting that these two receptor systems are coupled to distinct PTKs. Since tyrosine phosphorylation of cellular proteins has been shown to be a crucial biochemical event in cell growth, our findings suggest that the induction of pp105 tyrosine phosphorylation via VLA-4 may play a role in the transduction of activation signals through this molecule.

Published
1992

10. Comparing the Social Construction of Unemployment, in France, Japan and Brazil

Author

Demazière, Didier, K, Sugita., Professions, institutions, temporalités (PRINTEMPS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS), and Fghf, Fdggggdf

Subjects
[SHS.SOCIO]Humanities and Social Sciences/Sociology, [SHS.SOCIO] Humanities and Social Sciences/Sociology
Published
2006

11. Endovascular Treatment of Ruptured Anterior Communicating Artery Aneurysms: Results and Technical Considerations

Author

Noriyuki Kato, S. Okamoto, Makoto Sonobe, Y. Nakai, K. Sugita, and K. Nakamura

Subjects
medicine.medical_specialty, medicine.diagnostic_test, Guglielmi detachable coil, business.industry, medicine.medical_treatment, Perforation (oil well), Original Articles, medicine.disease, Surgery, Anterior communicating artery, Aneurysm, medicine.artery, Angiography, medicine, cardiovascular system, Embolization, cardiovascular diseases, Endovascular treatment, business, Complication
Abstract

The aim of this paper is to provide a review of our experience in using the endovascular treatment of ruptured anterior communicating artery (ACoA) aneurysms. Between March 1997 and May 2004, 211 ruptured aneurysms were treated with Guglielmi detachable coil (GDC) system in Mito Medical Center, 73 were located at the ACoA. Two cases were incomplete embolization, and performed microsurgical clipping. In the initial embolization for the 71 aneurysms, complete occlusion was achieved in 44 aneurysms, neck remnant in 11 aneurysms and body filling in 16 aneurysms. Intra-operative complication was occurred in six cases (8.2%). Aneurysm perforation was occurred in three cases (4.1%), thromboembolic complication was occurred in three cases (4.1%). Acute rebleeding were observed in two cases (2.7%). Endovascular treatment is an effective technique for treating ACoA aneurysms, and 3D-rotational angiography is important diagnostic tool for evaluating the ACoA complex.

Published
2006

12. Unemployed ? No., I'm a job searcher. Institutional frameworks and individual perceptions in a comparative perspective

Author

Demazière, Didier, H, Hirata., K, Sugita., N, Guimaràes, Professions, institutions, temporalités (PRINTEMPS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS), and Fghf, Fdggggdf

Subjects
[SHS.SOCIO]Humanities and Social Sciences/Sociology, [SHS.SOCIO] Humanities and Social Sciences/Sociology
Abstract

24P.

Published
2005

14. Prolonged impairment of very late activating antigen-mediated T cell proliferation via the CD3 pathway after T cell-depleted allogeneic bone marrow transplantation

Author

K Sugita, Kouichi Tachibana, Chikao Morimoto, Robert J. Soiffer, Stuart F. Schlossman, Christopher J L Murray, Jerome Ritz, and Yoshihisa Nojima

Subjects
Integrins, CD3 Complex, CD3, T cell, T-Lymphocytes, Integrin, chemical and pharmacologic phenomena, Lymphocyte Activation, Lymphocyte Depletion, chemistry.chemical_compound, Antigen, immune system diseases, Antigens, CD, Receptors, Very Late Antigen, hemic and lymphatic diseases, medicine, Cell Adhesion, Humans, Transplantation, Homologous, Phosphorylation, Cell adhesion, Receptor, Bone Marrow Transplantation, biology, Integrin beta1, Tyrosine phosphorylation, hemic and immune systems, General Medicine, Molecular biology, Transplantation, medicine.anatomical_structure, surgical procedures, operative, chemistry, Immunology, biology.protein, Tyrosine, Research Article
Abstract

One of the major obstacles in allogeneic bone marrow transplantation (allo-BMT) is prolonged T cell dysfunction resulting in a variety of infectious complications in the months to years after hematologic engraftment. We previously showed that immobilized extracellular matrix (ECM) proteins such as fibronectin (FN), the CS-1 domain of FN, or collagen (CO) acted synergistically with immobilized anti-CD3 to induce T cell proliferation. In addition, the comitogenic effect of ECMs could be mimicked by immobilized mAb reactive with a common beta 1 chain (CD29) of very late activating (VLA) antigens which include ECM receptors. Since the interaction of T cells with ECMs appears to play an important role in the process of T cell reconstitution following allo-BMT, we examined the expression of VLA antigens (alpha 1-alpha 6, beta 1) and their functional roles in CD3-mediated T cell proliferation at various times after T cell depleted allo-BMT. VLA beta 1 as well as VLA alpha 4, alpha 5, and alpha 6 expression was lower than normal controls during the first 3 mo after allo-BMT and auto-BMT, whereas these expressions returned to normal levels by 4 mo after allo-BMT and auto-BMT. Although alpha 1 and alpha 2 were not expressed on lymphocytes from normal controls, these antigens were expressed on lymphocytes at the detectable levels (5-15%) from patients after allo-BMT and auto-BMT. Both CD29 and CD3 were expressed at normal levels on lymphocytes from patients > 3 mo after allo-BMT, whereas T cell interaction with ECM through VLA proteins or crosslinking of VLA beta 1 expressed by T cells with anti-CD29 mAb results in poor induction of CD3-mediated T cell proliferation for a prolonged period (> 1 yr) after allo-BMT. In contrast, T cell proliferation induced by crosslinking of anti-CD2 or anti-CD26 with anti-CD3 was almost fully recovered by 1 yr post-allo-BMT. After autologous BMT, impaired VLA-mediated T cell proliferation via the CD3 pathway after auto-BMT returned to normal levels within 1 yr despite no significant difference in CD3 and CD29 expression following either allo- or auto-BMT. The adhesion of T cells from post-allo-BMT patients to FN-coated plate was normal or increased compared to that of normal controls. Moreover, the induction of the tyrosine phosphorylation of pp105 protein by the ligation of VLA molecules was not impaired in allo-BMT patients. These results suggest that there are some other defects in the process of VLA-mediated signal transduction in such patients. Our results imply that disturbance of VLA function could explain, at least in part, the persistent immunoincompetent state after allo-BMT and may be involved in susceptibility to opportunistic infections after allo-BMT.

Published
1994

15. Feasibility of gene-immunotherapy using WT1-specific T-cell receptor gene transfer for infant acute lymphoblastic leukemia with MLL gene rearrangement

Author

Sachiko Okamoto, Masaki Yasukawa, K Sugita, Hiroshi Shiku, Kozo Nagai, Eiichi Ishii, Toshiki Ochi, Hiroshi Fujiwara, K Koh, and Junichi Mineno

Subjects
medicine.medical_specialty, Hematology, business.industry, medicine.medical_treatment, hemic and immune systems, Immunotherapy, medicine.disease, Infant Acute Lymphoblastic Leukemia, Fusion gene, Leukemia, Haematopoiesis, Oncology, hemic and lymphatic diseases, T-Cell Receptor Gene, Internal medicine, Immunology, Cancer research, Medicine, business, neoplasms, Gene, Letter to the Editor
Abstract

Feasibility of gene-immunotherapy using WT1-specific T-cell receptor gene transfer for infant acute lymphoblastic leukemia with MLL gene rearrangement

Published
2011

19. Current practice regarding the diagnosis and treatment of anorectal malformations in female patients: a multicenter questionnaire survey in Japan.

Author

Harumatsu T, Murakami M, Nagano A, Sugita K, Ishimaru T, Fujino A, Nakata M, Aoi S, Soh H, Kinoshita Y, Uchida K, Hirabayashi T, Fuchimoto Y, Okajima H, Yonekura T, Koshinaga T, Yagi M, Matsufuji H, Hirobe S, Nio M, Ueno S, Iwai J, Kuroda T, and Ieiri S

Abstract

Purpose: This study aimed to investigate the current practices in the diagnosis and surgical management of anorectal malformations (ARMs) in female patients in Japan, specifically focusing on anovestibular fistula (AVF), rectovaginal fistula (RVF), and persistent cloaca (PC)., Methods: An anonymous online survey was conducted with 61 institutional members of the Japanese Study Group for Anorectal Anomalies., Results: Sixty-one institutions (100%) completed the survey. For AVF, fistulography/vaginography was the most common diagnostic method (98.4%), and anorectoplasty was usually performed at 3-6 months of age (86.9%) using anterior sagittal anorectoplasty (62.3%) or anal transposition (39.3%). Distal colostography (100%), MRI (71.7%), and cystscopy/urethroscopy/vaginoscopy (83.3%) were commonly used for PC. Patients with PC underwent anorectoplasty at 7-24 months (93.3%), predominantly posterior sagittal anorecto-urethro-vaginoplasty (PSARUVP) (41.7%), or laparoscopy-assisted anorectoplasty (LAARP) (43.3%). A subgroup analysis revealed that PSARUVP used blunt dissection (70.0% vs. 28.6%, p < 0.05) and visual confirmation by opening the rectum (80.0% vs. 4.8%, p < 0.001) significantly more often than LAARP for PC., Conclusion: This nationwide survey revealed distinct patterns in the diagnostic timing and surgical approaches for female ARMs in Japan, highlighting the varying preferences in fistula management techniques across different types of malformations., Competing Interests: Declarations. Conflict of interest: The authors declare no conflicts of interest in association with the present study., (© 2024. The Author(s) under exclusive licence to Springer Nature Singapore Pte Ltd.)

Published
2024
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20. Real-world safety and efficacy of biologics in elderly patients with psoriasis: A multicenter observational study.

Author

Ohata C, Anezaki H, Yanase T, Katayama E, Kaneko S, Saito K, Yamane M, Nakamaru S, Tsuruta N, Okazaki F, Ito K, Kikuchi S, Koike Y, Miyagi T, Sugita K, Nakahara T, Takezaki D, Saruwatari H, Yoshida Y, Yonekura K, Higashi Y, Sawada Y, Chinuki Y, Yamaguchi K, and Imafuku S

Subjects
Humans, Male, Female, Aged, Japan epidemiology, Middle Aged, Age Factors, Treatment Outcome, Adult, Incidence, Follow-Up Studies, Severity of Illness Index, Dermatologic Agents adverse effects, Dermatologic Agents therapeutic use, Neoplasms drug therapy, Psoriasis drug therapy, Biological Products adverse effects, Biological Products therapeutic use, Registries statistics & numerical data
Abstract

Clinical trials of biologics have frequently excluded elderly patients, resulting in inadequate data on their safety and efficacy. Additionally, evidence of their safety and efficacy remains limited, despite some real-world studies. To assess the safety and efficacy of biologics in elderly patients with psoriasis, we compared these outcomes in younger patients using data from the West Japan Psoriasis Registry (WJPR). The WJPR consists of approximately 30 facilities in Western Japan, including various healthcare settings. This study enrolled 1395 patients who participated in the 2022 follow-up survey of the WJPR and were either using or had used biologics during the survey. These included 456 patients in the elderly group (≥65 years) and 939 patients in the younger group (<65 years). Treatment-ending adverse events (TEAEs) occurred in 15.8% and 11.3% of elderly and younger patients, respectively. The incidence rate per 1000 patient-years (PY) for TEAEs was significantly higher in elderly patients than in younger patients (32.9 vs 23.2, p = 0.0234). Infectious diseases were more prevalent in the elderly group than the younger group; however, no significant difference in the frequency of infectious diseases was found between the two groups (p = 0.0807). Malignant neoplasms occurred significantly more frequently in the elderly group than in the younger group (p = 0.0169). Our results indicate a few concerns about infection when prescribing biologics to elderly patients. Biologics were effective for both elderly and younger patients. We found no significant differences in the proportion of patients with a body surface area score ≤3%, Physician's Global Assessment score 0/1, or Patient's Global Assessment score 0/1, as well as in the mean Dermatology Life Quality Index and the Itch Numerical Rating Scale between the younger and the elderly groups. Overall, our results confirm the appropriateness of using biologics in elderly patients with regard to safety and efficacy., (© 2024 Japanese Dermatological Association.)

Published
2024
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21. Favorable inhibitory effect of clodronate on hepatic steatosis in short bowel syndrome model rats.

Author

Tsuruno Y, Nagano A, Sugita K, Onishi S, Tabata Y, Kedoin C, Murakami M, Yano K, Kawano T, Hasuzawa N, Nomura M, Kaji T, Bitoh Y, and Ieiri S

Subjects
Animals, Rats, Male, Rats, Sprague-Dawley, Liver drug effects, Liver pathology, Short Bowel Syndrome complications, Disease Models, Animal, Fatty Liver, Clodronic Acid therapeutic use
Abstract

Purpose: This study investigated the anti-inflammatory effect of clodronate, a vesicular nucleotide transporter (VNUT) inhibitor, on intestinal-failure-associated liver disease (IFALD) in a rat model of short bowel syndrome (SBS)., Methods: The rats underwent jugular vein catheterization for continuous total parenteral nutrition (TPN) and 90% small bowel resection. The animals were divided into the following groups: TPN/SBS (Control group), TPN/SBS/intravenous administration of low-dose clodronate (20 mg/kg twice per week; Low group), or TPN/SBS/intravenous administration of high-dose clodronate (60 mg/kg twice per week; High group). On day 7, the rats were euthanized. Hepatic steatosis and hepatocellular injury were also assessed., Results: Hepatic steatosis and lobular inflammation in the liver were observed in all groups. The High group showed histologically reduced hepatic steatosis compared with the Control group. IL-6 and Nlrp3 expression in the High group was significantly suppressed compared to that in the Control group. The expression of other inflammatory cytokines tended to be lower in the High dose group than in the control group. The lipid metabolism gene expression in the liver specimens showed no significant differences among the groups., Conclusion: The high-dose administration of clodronate may, therefore, inhibit hepatic steatosis and inflammation associated with IFALD in patients with SBS., Competing Interests: Declarations Conflict of interest Yudai Tsuruno and the other co-authors have no conflicts of interest to declare. Data availability The datasets generated and/or analyzed during the current study are available from the corresponding author upon reasonable request., (© 2024. The Author(s).)

Published
2024
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22. Human Astrovirus Infection and Outbreaks in Japanese Children Before and After the Emergence of COVID-19 Pandemic.

Author

Ushijima H, Pham NTK, Nishimura S, Kobayashi M, Sugita K, Hoque SA, Kumthip K, Kotaki T, Onda-Shimizu Y, Okitsu S, Komoto S, Kobayashi T, Komine-Aizawa S, Hayakawa S, Maneekarn N, and Khamrin P

Subjects
Humans, Japan epidemiology, Child, Preschool, Infant, Child, Female, Male, Prevalence, Adolescent, SARS-CoV-2 genetics, SARS-CoV-2 isolation & purification, Phylogeny, Infant, Newborn, Coinfection epidemiology, Coinfection virology, East Asian People, Astroviridae Infections epidemiology, Astroviridae Infections virology, Feces virology, COVID-19 epidemiology, COVID-19 virology, Mamastrovirus isolation & purification, Mamastrovirus genetics, Mamastrovirus classification, Disease Outbreaks, Diarrhea epidemiology, Diarrhea virology
Abstract

Human astroviruses (HAstVs) were examined in 1625 stool samples collected from outpatient children with diarrhea who visited clinics in 4-6 prefectures in Japan. The study was conducted over a period of 4 years from July 2018 to June 2022, spanning the period before and after the emergence of COVID-19. The HAstV and other diarrheal viruses including group A rotavirus, norovirus and sapovirus were screened by RT-PCR. Of these, HAstV was detected in 140 out of 1625 (8.6%). When the stool samples were categorized by the year of collection, HAstV was detected in 2018-2019, 2019-2020, 2020-2021, and 2021-2022 with the prevalences of 3.1%, 6.6%, 3.0%, and 20.1%, respectively. Among 140 HAstV positive cases, HAstV1, MLB1, MLB2, HAstV3, MLB3, and VA2 were detected in 77, 46, 10, 3, 2, and 2 samples, respectively. High infection rate was found in children 1-3 years of age (95/140; 67.9%). Severity of the disease increased with the co-infection with norovirus. During the surveillance of 2021-2022, two outbreaks of HAstV were detected, one was an outbreak of HAstV1 and MLB2 in September, 2021 in Kyoto, the second was an outbreak of HAstV1 and MLB1 in December, 2021 in Kyoto and Shizuoka. It was interesting to observe that mixed-infection of astroviruses between HAstV1 and MLB1 was reported for the first time in this study. Characterization of the subgenotypes in HAstV1 and HAstV3 indicated that most HAstV1 circulating in Japan belonged to HAstV1a and only a single strain was HAstV1b, whereas all HAstV3 was identified as the HAstV3c subgenotype. In conclusion, several HAstV genotypes, including classic HAstV, novel MLB, and VA genotypes, were detected in this study. The incidence of astrovirus outbreaks was also reported after the pandemic of COVID-19 in 2021-2022., (© 2024 Wiley Periodicals LLC.)

Published
2024
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24. Enhanced lymphangiogenesis in the left lateral segment of a biopsied liver during portoenterostomy for biliary atresia.

Author

Tsuruno Y, Sugita K, Muraji T, Masuya R, Harumatsu T, Yano K, Onishi S, Kawano T, Ichikawa C, Ohtani H, Bitoh Y, and Ieiri S

Subjects
Humans, Male, Female, Infant, Biopsy, Portal Vein surgery, Portal Vein pathology, Lymphatic Vessels pathology, Child, Preschool, Biliary Atresia surgery, Biliary Atresia pathology, Portoenterostomy, Hepatic methods, Lymphangiogenesis, Liver pathology
Abstract

Purpose: We investigate the histopathology of the portal vein branches and lymphatic vessels to elucidate the mechanism of atrophy of the left lateral segment (LLS) of the liver in biliary atresia (BA)., Methods: LLS and right anterior segment (RAS) liver biopsy samples obtained during Kasai portoenterostomy (KPE) from ten consecutive patients with BA underwent histopathological investigation of the portal vein and lymphatic vessels using double chromogenic immunostaining for CD31/D2-40 and the hepatitis-like findings (HLF) score. Each parameter and clinical data were compared between prognostic groups., Results: HLF scores in the LLS were always higher than those in the RAS. There was no difference in portal vein and lymphatic vascular morphology, whereas the number of lymphatic vessels was correlated with the fibrotic area of all specimen areas. Left-to-right ratio of the number of lymphatic vessels was correlated with the age at KPE (r = 0.784, p = 0.007) and the pre-KPE CRP value (r = 0.723, p = 0.018)., Conclusions: Lymphangiogenesis on the LLS compared to the RAS was significantly correlated with the degree of fibrosis and the age at KPE. Further investigation is warranted to clarify the causes of LLS atrophy and lymphangiogenesis relevant to immune dysregulation., (© 2024. The Author(s).)

Published
2024
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25. Persistence of post-stress blood pressure elevation requires activation of astrocytes.

Author

Hasebe Y, Yokota S, Fukushi I, Takeda K, Yoshizawa M, Onimaru H, Kono Y, Sugama S, Uchiyama M, Koizumi K, Horiuchi J, Kakinuma Y, Pokorski M, Toda T, Izumizaki M, Mori Y, Sugita K, and Okada Y

Subjects
Animals, Rats, Male, Hypertension physiopathology, Hypertension metabolism, Rats, Sprague-Dawley, Heart Rate, Neurons metabolism, Brain metabolism, Proto-Oncogene Proteins c-fos metabolism, Astrocytes metabolism, Blood Pressure, Stress, Psychological physiopathology
Abstract

The reflexive excitation of the sympathetic nervous system in response to psychological stress leads to elevated blood pressure, a condition that persists even after the stress has been alleviated. This sustained increase in blood pressure, which may contribute to the pathophysiology of hypertension, could be linked to neural plasticity in sympathetic nervous activity. Given the critical role of astrocytes in various forms of neural plasticity, we investigated their involvement in maintaining elevated blood pressure during the post-stress phase. Specifically, we examined the effects of arundic acid, an astrocytic inhibitor, on blood pressure and heart rate responses to air-jet stress. First, we confirmed that the inhibitory effect of arundic acid is specific to astrocytes. Using c-Fos immunohistology, we then observed that psychological stress activates neurons in cardiovascular brain regions, and that this stress-induced neuronal activation was suppressed by arundic acid pre-treatment in rats. By evaluating astrocytic process thickness, we also confirmed that astrocytes in the cardiovascular brain regions were activated by stress, and this activation was blocked by arundic acid pre-treatment. Next, we conducted blood pressure measurements on unanesthetized, unrestrained rats. Air-jet stress elevated blood pressure, which remained high for a significant period during the post-stress phase. However, pre-treatment with arundic acid, which inhibited astrocytic activation, suppressed stress-induced blood pressure elevation both during and after stress. In contrast, arundic acid had no significant impact on heart rate. These findings suggest that both neurons and astrocytes play integral roles in stress-induced blood pressure elevation and its persistence after stress, offering new insights into the pathophysiological mechanisms underlying hypertension., (© 2024. The Author(s).)

Published
2024
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27. Acute Kidney Injury Associated With Red Yeast Rice (Beni-kōji) Supplement: A Report of Two Cases.

Author

Uchiyama K, Otani M, Chigusa N, Sugita K, Matsuoka R, Hosoya K, Komuta M, Ito J, and Washida N

Abstract

Numerous health concerns, primarily kidney injury, have been reported with the use of Beni-kōji CholesteHelp, a functional food containing red yeast rice. Here, we describe 2 cases of kidney injury caused by beni-kōji. The first case had normal kidney function before consuming the product. After several months of use, she developed hypertension. After 6 months of supplement consumption, her estimated glomerular filtration rate (eGFR) dropped to 22.5 mL/min/1.73 m 2 . A spot urine sample showed a urinary protein-to-creatinine ratio of 2.03 g/g, leading to the diagnosis of Fanconi syndrome. Kidney biopsy showed tubular degeneration. Thirty-five days after discontinuing the supplement, proteinuria resolved and the eGFR returned to baseline level. The second case, who had diabetes and normal kidney function, experienced severe kidney injury (eGFR, 3.5 mL/min/1.73 m 2 ) after 4 months of Beni-kōji CholesteHelp use. He required hemodialysis for >2 weeks but recovered kidney function after the product was discontinued. Kidney biopsy showed tubular injury similar to the first case and glomeruli changes consistent with diabetic nephropathy. These cases indicate that beni-kōji use is associated with tubular toxicity. Further studies are required to identify the precise etiology and mechanism of kidney injury., (© 2024 The Authors.)

Published
2024
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28. Commensal consortia decolonize Enterobacteriaceae via ecological control.

Author

Furuichi M, Kawaguchi T, Pust MM, Yasuma-Mitobe K, Plichta DR, Hasegawa N, Ohya T, Bhattarai SK, Sasajima S, Aoto Y, Tuganbaev T, Yaginuma M, Ueda M, Okahashi N, Amafuji K, Kiridoshi Y, Sugita K, Stražar M, Avila-Pacheco J, Pierce K, Clish CB, Skelly AN, Hattori M, Nakamoto N, Caballero S, Norman JM, Olle B, Tanoue T, Suda W, Arita M, Bucci V, Atarashi K, Xavier RJ, and Honda K

Subjects
Animals, Humans, Mice, Escherichia growth & development, Escherichia pathogenicity, Feces microbiology, Gluconates metabolism, Inflammation microbiology, Inflammation prevention & control, Inflammation therapy, Intestines microbiology, Klebsiella growth & development, Klebsiella pathogenicity, Mice, Inbred C57BL, Probiotics therapeutic use, Drug Resistance, Bacterial, Enterobacteriaceae growth & development, Enterobacteriaceae pathogenicity, Enterobacteriaceae Infections microbiology, Enterobacteriaceae Infections prevention & control, Enterobacteriaceae Infections therapy, Gastrointestinal Microbiome physiology, Symbiosis physiology
Abstract

Persistent colonization and outgrowth of potentially pathogenic organisms in the intestine can result from long-term antibiotic use or inflammatory conditions, and may perpetuate dysregulated immunity and tissue damage 1,2 . Gram-negative Enterobacteriaceae gut pathobionts are particularly recalcitrant to conventional antibiotic treatment 3,4 , although an emerging body of evidence suggests that manipulation of the commensal microbiota may be a practical alternative therapeutic strategy 5-7 . Here we isolated and down-selected commensal bacterial consortia from stool samples from healthy humans that could strongly and specifically suppress intestinal Enterobacteriaceae. One of the elaborated consortia, comprising 18 commensal strains, effectively controlled ecological niches by regulating gluconate availability, thereby re-establishing colonization resistance and alleviating Klebsiella- and Escherichia-driven intestinal inflammation in mice. Harnessing these activities in the form of live bacterial therapies may represent a promising solution to combat the growing threat of proinflammatory, antimicrobial-resistant Enterobacteriaceae infection., (© 2024. The Author(s).)

Published
2024
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29. Current practice of diagnosis and treatment for rectourethral fistula in male patients with anorectal malformation: a multicenter questionnaire survey in Japan.

Author

Harumatsu T, Murakami M, Sugita K, Ishimaru T, Fujino A, Nakata M, Aoi S, Soh H, Kinoshita Y, Uchida K, Hirabayashi T, Fuchimoto Y, Okajima H, Yonekura T, Koshinaga T, Yagi M, Matsufuji H, Hirobe S, Nio M, Ueno S, Iwai J, Kuroda T, and Ieiri S

Subjects
Humans, Male, Japan, Surveys and Questionnaires, Anus, Imperforate surgery, Anus, Imperforate diagnosis, Laparoscopy methods, Rectal Fistula surgery, Rectal Fistula diagnosis, Anorectal Malformations surgery, Urinary Fistula surgery, Urinary Fistula diagnosis, Urethral Diseases surgery, Urethral Diseases diagnosis
Abstract

Purpose: Surgical procedures for anorectoplasty for anorectal malformations (ARMs), particularly rectourethral fistula (RUF), depend on the institution. We investigated the diagnosis and treatment of RUF in male patients with ARMs in Japan using a questionnaire survey., Methods: An online survey inquiring about the diagnosis and treatment (diagnostic modalities, surgical approaches, fistula dissection devices, and fistula closure techniques) of each type of ARM in male patients was conducted among institutional members of the Japanese Study Group of Anorectal Anomalies. Fisher's exact test was used to compare surgical methods between posterior sagittal anorectoplasty (PSARP) and laparoscopy-assisted anorectoplasty (LAARP)., Results: Sixty-one institutions (100%) completed the survey. LAARP was the preferred approach for high-type ARM (75.4%). PSARP was preferred for intermediate-type ARM (59.0%). Monopolar devices were most commonly used (72.1%) for RUF dissection. Blunt dissection was more frequent in the PSARP group (PSARP vs. LAARP: 55.6 vs. 20.0%, p < 0.005). Cystoscopy/urethroscopy to confirm the extent of dissection was used more frequently in the LAARP group (70.0% vs. 25.0%, p < 0.005). Clips and staplers were used more frequently in the LAARP group (p < 0.05)., Conclusion: Distinct fistula management strategies for PSARP and LAARP were revealed. Further studies are needed to investigate the postoperative outcomes associated with these practices., (© 2024. The Author(s).)

Published
2024
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30. Prognostic factors for pediatric patients with severe intestinal motility disorders: a single institution's experience.

Author

Yano K, Muto M, Sugita K, Murakami M, Onishi S, Harumatsu T, Iwamoto Y, Ogata M, Takada L, Nishida N, Kedoin C, Nagano A, Matsui M, Yamada K, Yamada W, Matsukubo M, Kawano T, Kaji T, and Ieiri S

Abstract

Purpose: To identify the prognostic factors for pediatric severe intestinal motility disorder (IMD)., Methods: We reviewed the medical records of patients with severe IMD, who required total parenteral nutrition (TPN) for ≥ 60 days at our institution between April, 1984 and March, 2023, examining their characteristics to identify prognostic factors., Results: The types of IMD in the 14 patients enrolled in this study were as follows: isolated hypoganglionosis (IHG, n = 6), extensive aganglionosis (EAG: n = 6), and chronic idiopathic intestinal pseudo-obstruction (CIIP, n = 2). There was no significant difference in mortality among the three types of severe IMD. Weaning-off TPN and the use of the colon were not significant prognostic factors, but cholestasis was a significant prognostic factor (p = 0.005). There was a high mortality rate (50%), with the major causes of death being intestinal failure-associated liver disease (IFALD) following hepatic failure, and catheter-related blood stream infection (CRBSI). One IHG patient underwent small bowel transplantation but died of acute rejection., Conclusion: Severe IMD is still associated with a high mortality rate and cholestasis predicts the prognosis. Thus, preventing or improving IFALD and CRBSI caused by long-term TPN is important for reducing the mortality rate., (© 2024. The Author(s).)

Published
2024
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31. Functional Outcome in Patients With Anorectal Malformation With Recto-prostatic or Recto-bulbar Urethral Fistula and Comparison Between Different Surgical Approaches: A Multi-center Study.

Author

Wong CWY, Koga H, Sugita K, Kato D, Mutanen A, Chung PHY, Miyano G, Harumatsu T, Ieiri S, Nakagawa Y, Uchida H, Pakarinen MP, and Wong KKY

Abstract

Purpose: To analyze and compare the outcomes in patients with anorectal malformation with rectoprostatic and rectourethral fistula between laparoscopic-assisted anorectoplasty (LAARP) versus posterior sagittal anorectoplasty (PSARP)., Method: We performed a retrospective review on all males with anorectal malformation (ARM) with recto-prostatic (ARM-RP) or recto-bulbar urethral fistula (ARM-RB) treated in five tertiary paediatric surgical centres in the past 25 years. Defecative function was assessed using the Krickenbeck classification and Kelly's score. Functional outcomes between patients with LAARP and PSARP were compared., Results: There were a total of 136 males with ARM-RP and ARM-RB for analysis, among which 73 (53.7%) had ARM-RP and 63 (46.3%) had ARM-RB. The median age of the patients was 9.4 years (range 0.8-24.7 years) and the median age at operation was 0.4 years (0 day-3.1 years). 57 (41.9%) and 79 patients (58.1%) underwent PSARP and LAARP respectively. 34 patients (25%) had VACTERL association. 111 (81.6%) and 103 patients (75.7%) had sacral and spinal cord anomalies respectively. 19 patients (13.9%) eventually required Malone's Antegrade Continence Enema (MACE). For the comparison between PSARP and LAARP, no difference in Kelly scores (4.58 ± 1.63 versus 4.67 ± 1.36) was identified (p = 0.79). Logistic regression for voluntary bowel movement showed that VACTER association (p = 0.02) and fistula location (p = 0.01) were significant prognostic factors, whereas the operation approach (PSARP or LAARP) was not (p = 0.65)., Conclusion: VACTERL association and fistula location were significant prognostic factors for voluntary bowel movement, and there appeared to be no significant difference in functional outcome between PSARP and LAARP., Level of Evidence: IV., Competing Interests: Conflicts of interest All authors have indicated they have no potential conflicts of interest to disclose., (Copyright © 2024 Elsevier Inc. All rights reserved.)

Published
2024
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32. Isolation, structural determination, and antiviral activities of a novel alanine-conjugated polyketide from Talaromyces sp.

Author

Mosu N, Yasukochi M, Nakajima S, Nakamura K, Ogata M, Iguchi K, Kanno K, Ishikawa T, Sugita K, Murakami H, Kuramochi K, Saito T, Takeda S, Watashi K, Fujino K, and Kamisuki S

Subjects
Animals, Herpesvirus 1, Suid drug effects, SARS-CoV-2 drug effects, Swine, Magnetic Resonance Spectroscopy, Molecular Structure, Talaromyces chemistry, Antiviral Agents pharmacology, Antiviral Agents chemistry, Antiviral Agents isolation & purification, Polyketides pharmacology, Polyketides chemistry, Polyketides isolation & purification, Alanine pharmacology, Alanine chemistry, Alanine analogs & derivatives
Abstract

Antiviral agents are highly sought after. In this study, a novel alkylated decalin-type polyketide, alaspelunin, was isolated from the culture broth of the fungus Talaromyces speluncarum FMR 16671, and its structure was determined using spectroscopic analyses (1D/2D NMR and MS). The compound was condensed with alanine, and its absolute configuration was determined using Marfey's method. Furthermore, the antiviral activity of alaspelunin against various viruses was evaluated, and it was found to be effective against both severe acute respiratory syndrome coronavirus 2 and pseudorabies (Aujeszky's disease) virus, a pathogen affecting pigs. Our results suggest that this compound is a potential broad-spectrum antiviral agent., (© 2024. The Author(s), under exclusive licence to the Japan Antibiotics Research Association.)

Published
2024
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33. Freezing treatment under light conditions leads to a dramatic enhancement of freezing tolerance in cold-acclimated Arabidopsis.

Author

Sugita K, Takahashi S, Uemura M, and Kawamura Y

Subjects
Phytochrome B metabolism, Phytochrome B genetics, Mutation, Cold Temperature, Arabidopsis physiology, Arabidopsis genetics, Freezing, Acclimatization, Light, Gene Expression Regulation, Plant, Arabidopsis Proteins metabolism, Arabidopsis Proteins genetics
Abstract

Overwintering plants survive subzero temperatures by cold acclimation (CA), wherein they acquire freezing tolerance through short-term exposure to low temperatures above 0°C. The freezing tolerance of CA plants increases when they are subsequently exposed to mild subzero temperatures, a phenomenon known as second-phase cold hardening (2PH). Here, we explored the molecular mechanism and physiological conditions of 2PH. The results show that, compared with supercooling, a freezing treatment during 2PH after CA enhanced the freezing tolerance of Arabidopsis. This required CA as a pretreatment, and was designated as second-phase freezing acclimation (2PFA). Light increased the effect of 2PFA to enhance freezing tolerance after CA. C-repeat binding factor and cold-regulated genes were downregulated by light during the 2PFA treatment, a different transcription profile from that during CA. The freezing tolerance of 2PFA plants was decreased by the presence of the photosynthetic electron transfer inhibitor 3-(3,4-dichlorophenyl)-1,1-dimethylurea during the 2PFA treatment. Compared with wild-type plants, phototropin1,2 and phyb mutants showed lower freezing tolerance after 2PFA treatment. These results show that exposure to freezing after CA increases freezing tolerance as a secondary process, and that freezing under light conditions further increases freezing tolerance via pathways involving photoreceptors and photosynthetic electron transfer., (© 2024 The Authors. Plant, Cell & Environment published by John Wiley & Sons Ltd.)

Published
2024
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34. Adipose tissue remodeling via TSLP-mediated IL-4/IL-13 signaling: Implications for atopic dermatitis and skin barrier.

Author

Sugita K

Subjects
Humans, Animals, Mice, Dermatitis, Atopic immunology, Dermatitis, Atopic metabolism, Interleukin-13 metabolism, Interleukin-13 immunology, Interleukin-4 metabolism, Interleukin-4 immunology, Signal Transduction, Cytokines metabolism, Thymic Stromal Lymphopoietin, Skin metabolism, Skin immunology, Skin pathology, Adipose Tissue metabolism, Adipose Tissue immunology
Abstract

Competing Interests: Disclosure statement Disclosure of potential conflict of interest: The author declares that he has no relevant conflicts of interest.

Published
2024
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35. Evaluation of skill acquisition characteristics depending on the size of a dry box.

Author

Murakami M, Nishida N, Nagano A, Sugita K, Yano K, Harumatsu T, Onishi S, Yamada K, Yamada W, Kawano T, Muto M, and Ieiri S

Subjects
Humans, Female, Male, Young Adult, Endoscopy education, Endoscopy methods, Adult, Surgical Instruments, Clinical Competence, Students, Medical, Learning Curve
Abstract

Background: Few studies have analyzed the effect of the size of the working space in training on the acquisition of endoscopic skills. In this study, adult- and infant-sized dry boxes (DBs) were used to verify how the size of the working space in training affects forceps manipulation and learning curve., Material and Methods: Seventy-two medical students were enrolled. The task was peg transfer. The training environment was divided into adult- and infant-sized DBs. Skill evaluations were also divided into adult- and infant-sized DBs (four groups in total). The forceps manipulation characteristics and task completion time were compared before and after training., Results: Regarding skill evaluations using adult-sized DBs, there were no significant differences between the infant- and adult-sized DB-trained groups. Regarding skill evaluations using infant-sized DBs, there were no significant differences between the groups before training. After training, there was no significant difference in the total path length or average acceleration of the forceps between the groups. However, the infant-sized DB-trained group had a significantly faster average forceps velocity and faster task completion time than the adult-sized DB-trained group., Conclusion: Training with a small DB is more efficient in acquiring smoother and faster forceps manipulation in a small working space.

Published
2024
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36. Chemoselective one-pot cleavage and oxidation of silyl ethers to corresponding carbonyl compounds using IBX and acid catalysts.

Author

Kamo S, Hori K, and Sugita K

Abstract

Herein, we describe the chemoselective one-pot cleavage and oxidation of silyl ethers using catalytic amount of TsOH·H 2 O and IBX in DMSO. The oxidation of primary alkyl TBS ethers afforded the corresponding aldehydes in 51-94% yields, in the presence of aryl TBS, MOM, and PMB ethers, as well as N -Boc and acetonide groups. Secondary benzyl TBS ethers bearing aryl TBS ethers were also oxidized to ketones in moderate yields. A possible reaction pathway was also proposed.

Published
2024
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37. An ultrasound-guided supraclavicular approach for tunneled central venous catheter insertion can be safely performed by junior residents.

Author

Iwamoto Y, Onishi S, Sugita K, Nakame K, Kaji T, Yano K, Ogata M, Takada L, Kedoin C, Nagano A, Murakami M, Harumatsu T, Yamada K, Yamada W, Masuya R, Kawano T, Muto M, and Ieiri S

Subjects
Humans, Female, Male, Retrospective Studies, Brachiocephalic Veins diagnostic imaging, Brachiocephalic Veins surgery, Child, Infant, Child, Preschool, Central Venous Catheters, Jugular Veins diagnostic imaging, Adolescent, Catheterization, Central Venous methods, Internship and Residency methods, Ultrasonography, Interventional methods, Clinical Competence
Abstract

Purpose: Ultrasound-guided supraclavicular catheterization (UGSC) of the brachiocephalic vein (BCV) for long-term tunneled central venous catheter (tCVC) insertion may be safer than the internal jugular vein approach due to its superior field of view. We examined the clinical outcomes of tCVC insertions performed by junior residents through UGSC of the BCV., Patients and Methods: From January 2018 to December 2023, we assessed clinical outcomes and compared the experience levels of surgeons conducting tCVC insertions. Surgeons were categorized into three groups: junior residency (JR), senior residency (SR), and board-certified pediatric surgeons (BCPS)., Results: 177 tCVC insertions were done on 146 patients. Intraoperative complications included 6 cases of arterial puncture, 1 case of pneumothorax, 1 case of over insertion of catheter tip, and 1 case of suspected hemothorax. Distribution across groups was as follows: 28 cases (15.8%) in JR group, 92 (52.0%) in SR group, and 57 (32.2%) in BCPS group. Although the JR group exhibited longer operation times than the BCPS group, no significant differences in intraoperative complications were noted., Conclusion: Junior residents can safely perform UGSC for tCVC insertion. However, careful consideration of complications such as arterial or thoracic puncture is essential and case selection should be based on experience., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Published
2024
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38. Congenital Risk Factors for Chronic Kidney Disease in Patients With Persistent Cloaca: Results From a Nationwide Survey in Japan.

Author

Nagano A, Harumatsu T, Sugita K, Murakami M, Yano K, Onishi S, Kawano T, Ieiri S, and Kubota M

Abstract

Background: We conducted a nationwide survey of persistent cloaca (PC) to investigate the renal function outcomes and factors affecting chronic kidney disease (CKD) in patients with PC., Method: Information from 466 patients with PC was obtained via a questionnaire in this study. The 290 patients (62.2%) with renal function data were classified into 2 groups based on their estimated glomerular filtration rate: advanced CKD group (<30 mL/min/1.73 m 2 [or post-renal replacement therapy]) and non-advanced CKD group (≥30 mL/min/1.73 m 2 ). Univariate and multivariate analyses were performed to identify risk factors for CKD that may affect the renal function, including renal and urinary tract malformations, associated anomalies, and urinary tract treatment. The advanced CKD group was divided into two groups based on age to evaluate age-related differences (younger- and older-age CKD groups)., Results: A regression analysis revealed that congenital renal malformations (odds ratio [OR]: 14.06, 95% confidence interval [CI]:3.07-131.65, p < 0.0001), urinary tract obstruction (OR:4.28, 95%CI:1.12-24.23, p < 0.05), and sacral agenesis (OR:4.54, 95% CI:0.84-30.67, p < 0.05) were significantly associated with advanced CKD. In the univariate analysis of factors affecting the renal prognosis, clean intermittent catheterization (CIC) (OR:4.18, 95%CI:1.21-16.45, p = 0.015), vesicostomy (OR:3.65, 95%CI:1.11-12.98, p = 0.019), and surgery for vesicoureteral reflux (OR:5.43, 95%CI:1.41-22.73, p = 0.006) were significantly associated with advanced CKD. Based on the univariate analysis, hydrometrocolpos was significantly more prevalent in the older-age CKD group compared to the younger-age CKD group (p < 0.05)., Conclusion: CKD development in patients with PC is influenced by a complex interplay of factors, including renal malformations and neurogenic bladder dysfunction due to spinal anomalies., Level of Evidence: III (Study of Diagnostic Test, Study of nonconsecutive patients, and/or without a universally applied "gold" standard)., Competing Interests: Conflicts of interest The authors declare no conflicts of interest in association with the present study., (Copyright © 2024. Published by Elsevier Inc.)

Published
2024
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39. The Continuous and Reversible Transformation of the Polymorphs of an MGAT2 Inhibitor (S-309309) from the Anhydrate to the Hydrate in Response to Relative Humidity.

Author

Miyano T, Sugita K, and Ueda H

Abstract

Polymorphic control is vital for the quality control of pharmaceutical crystals. Here, we investigated the relationship between the hydrate and anhydrate polymorphs of a monoacylglycerol acyltransferase 2 inhibitor (S-309309). Solvent evaporation and slurry conversion revealed two polymorphs, the hydrate and the solvate. The solvate was transformed into the hydrate by heating. X-ray powder diffraction demonstrated that the hydrate was transformed into an anhydrate via an intermediate state when heated. These crystal forms were confirmed under controlled humidity conditions; the presence of the anhydrate, the intermediate hydrate, or the hydrate depended on the relative humidity at 25 °C. The stoichiometry of S-309309 in water in the hydrate form was 4:1. The hydrates and anhydrates exhibited similar crystal structures and stability. The water of hydration in the intermediate hydrate was 0.1-0.15 mol according to the dynamic vapor sorption profile. The stability and dissolution profile of the anhydrate and hydrate showed no significant change due to similar crystal lattices and quick rehydration of the anhydrate. A mechanism for the reversible crystal transformation between the anhydrate and pseudo-polymorphs of the hydrate was discovered. We concluded that S-309309 causes a pseudo-polymorphic transformation; however, this is not a critical issue for pharmaceutical use.

Published
2024
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40. Inflammation patterns in early post-operative cholangitis predict long-term outcomes in biliary atresia: a potential role of non-suppurative cholangitis.

Author

Harumatsu T, Muraji T, Masuya R, Tsuruno Y, Iwamoto Y, Ogata M, Takada L, Kedoin C, Nagano A, Murakami M, Sugita K, Yano K, Onishi S, Kawano T, Muto M, Kaji T, and Ieiri S

Subjects
Humans, Male, Female, Infant, Prognosis, Retrospective Studies, Child, Preschool, Inflammation blood, Biomarkers blood, Living Donors, Biliary Atresia surgery, Biliary Atresia complications, Cholangitis blood, Postoperative Complications, Liver Transplantation
Abstract

Purpose: Frequent post-operative cholangitis in biliary atresia (BA) affects the long-term native liver survival. This study assessed the characteristics of early cholangitis and their influence on the prognosis., Methods: Forty-three patients with BA who underwent surgery between 2000 and 2020 were analyzed for routine inflammatory markers. Early cholangitis characteristics were compared between native liver survivor (NLS) and living donor liver transplant (LDLT) patients., Results: Among the 43 patients, 30 (69.8%) experienced 130 episodes of cholangitis. In the area under the receiver operating characteristics curve (AUROC) analysis, the cutoff value of the total cholangitis episodes was 3, with an area under the AUROC curve of 0.695 (95% confidence interval 0.522-0.868). Before 3 years old, 113 episodes (86.9%) of cholangitis were observed. The white blood cell, C-reactive protein, and alanine aminotransferase values at cholangitis onset did not markedly differ between the LDLT and NLS groups. Conversely, the neutrophil-to-lymphocyte ratio in the NLS group was significantly lower than in the LDLT group (0.85 vs. 1.63, p < 0.001)., Conclusions: Cholangitis in the NLS group was lymphocyte-dominant and atypical in its pathogenesis. Lymphocyte-dominant cholangitis is non-suppurative, and future research should clarify its pathogenesis to improve the treatment and prognosis of BA., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Published
2024
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41. Impact of hepatocyte growth factor on the colonic morphology and gut microbiome in short bowel syndrome rat model.

Author

Sugita K, Yano K, Onishi S, Tabata Y, Iwamoto Y, Ogata M, Takada L, Kedoin C, Murakami M, Harumatsu T, Matsukubo M, Kawano T, Muto M, Kumagai K, Ido A, Kaji T, and Ieiri S

Subjects
Animals, Rats, Male, Toll-Like Receptor 4 metabolism, Toll-Like Receptor 4 genetics, Tight Junctions drug effects, Tight Junctions metabolism, Claudin-1 metabolism, Claudin-1 genetics, Hepatocyte Growth Factor metabolism, Hepatocyte Growth Factor genetics, Gastrointestinal Microbiome drug effects, Rats, Sprague-Dawley, Colon microbiology, Colon pathology, Disease Models, Animal, Short Bowel Syndrome metabolism, Short Bowel Syndrome microbiology
Abstract

Purpose: This study aimed to investigate the impact of hepatocyte growth factor (HGF) on colonic morphology and gut microbiota in a rat model of short bowel syndrome (SBS)., Methods: SD rats underwent jugular vein catheterization for total parenteral nutrition (TPN) and 90% small bowel resection [TPN + SBS (control group) or TPN + SBS + intravenous HGF (0.3 mg/kg/day, HGF group)]. Rats were harvested on day 7. Colonic morphology, gut microflora, tight junction, and Toll-like receptor-4 (TLR4) were evaluated., Results: No significant differences were observed in the colonic morphological assessment. No significant differences were observed in the expression of tight junction-related genes in the proximal colon. However, the claudin-1 expression tended to increase and the claudin-3 expression tended to decrease in the distal colon of the HGF group. The Verrucomicrobiota in the gut microflora of the colon tended to increase in the HGF group. The abundance of most LPS-producing microbiota was lower in the HGF group than in the control group. The gene expression of TLR4 was significantly downregulated in the distal colon of the HGF group., Conclusion: HGF may enhance the mucus barrier through the tight junctions or gut microbiome in the distal colon., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Published
2024
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42. The postoperative renal function of persistent cloaca patients treated by posterior sagittal anorecto-urethro-vaginopalsty: results of a nationwide survey in Japan.

Author

Sugita K, Harumatsu T, Nagano A, Yano K, Onishi S, Kawano T, Ieiri S, and Kubota M

Subjects
Humans, Japan epidemiology, Female, Male, Surveys and Questionnaires, Infant, Vagina surgery, Urethra surgery, Urethra abnormalities, Postoperative Complications epidemiology, Anal Canal surgery, Anal Canal abnormalities, Rectum surgery, Infant, Newborn, Child, Preschool, Cloaca abnormalities, Cloaca surgery, Kidney abnormalities, Kidney surgery, Kidney physiopathology
Abstract

Purpose: We investigated the postoperative renal function in persistent cloaca (PC) patients who underwent posterior sagittal anorecto-urethro-vaginopalsty (PSARUVP) and factors influencing the renal functional outcomes., Methods: A questionnaire survey was distributed to 244 university and children's hospitals across Japan. Of the 169 patients underwent PSARUVP, 103 patients were enrolled in the present study. Exclusion criteria was patients without data of renal prognosis., Results: The present study showed that renal anomalies (p = 0.09), vesicoureteral reflux (VUR) (p = 0.01), and hydrocolpos (p = 0.07) were potential factors influencing a decline in the renal function. Approximately half of the patients had a normal kidney function, but 45.6% had a reduced renal function (Stage ≥ 2 chronic kidney disease: CKD). The incidence of VUR was significantly higher in the renal function decline (RFD) group than those in the preservation (RFP) group (p = 0.01). Vesicostomy was significantly more frequent in the RFD group than in the RFP group (p = 0.04). Urinary tract infections (p < 0.01) and bladder dysfunction (p = 0.04) were significantly more common in patients with VUR than in patients without VUR. There was no association between the VUR status and the bowel function., Conclusions: Prompt assessment and treatment of VUR along with bladder management may minimize the decline in the renal function., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Published
2024
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43. Sub-acute oral exposure to lowest observed adverse effect level of nivalenol exacerbates atopic dermatitis in mice via direct activation of mitogen-activated protein kinase signal in antigen-presenting cells.

Author

Matsuzaka R, Yamaguchi H, Ohira C, Kurita T, Iwashita N, Takagi Y, Nishino T, Noda K, Sugita K, Kushiro M, Miyake S, and Fukuyama T

Subjects
Animals, Mice, Administration, Oral, RAW 264.7 Cells, Mitogen-Activated Protein Kinases metabolism, Antigen-Presenting Cells drug effects, Antigen-Presenting Cells immunology, MAP Kinase Signaling System drug effects, Disease Models, Animal, Dendritic Cells drug effects, Dendritic Cells metabolism, Dendritic Cells immunology, Phosphorylation, Male, Tumor Necrosis Factor-alpha metabolism, Female, Dermatitis, Atopic chemically induced, Dermatitis, Atopic immunology, Trichothecenes toxicity, Trichothecenes administration & dosage, Cytokines metabolism
Abstract

This study investigated the immunotoxic effects of the mycotoxin nivalenol (NIV) using antigen-presenting cells and a mouse model of atopic dermatitis (AD). In vitro experiments were conducted using a mouse macrophage cell line (RAW 264.7) and mouse dendritic cell line (DC 2.4). After cells were exposed to NIV (0.19-5 µmol) for 24 h, the production of pro-inflammatory cytokines (IL-1β, IL-6, and TNFα) was quantified. To further investigate the inflammatory cytokine production pathway, the possible involvement of mitogen-activated protein kinase (MAPK) pathways, such as ERK1/2, p-38, and JNK, in NIV exposure was analyzed using MAPK inhibitors and phosphorylation analyses. In addition, the pro-inflammatory effects of oral exposure to NIV at low concentrations (1 or 5 ppm) were evaluated in an NC/Nga mouse model of hapten-induced AD. In vitro experiments demonstrated that exposure to NIV significantly enhanced the production of TNFα. In addition, it also directly induced the phosphorylation of MAPK, indicated by the inhibition of TNFα production following pretreatment with MAPK inhibitors. Oral exposure to NIV significantly exacerbated the symptoms of AD, including a significant increase in helper T cells and IgE-produced B cells in auricular lymph nodes and secretion of pro-inflammatory cytokines, such as IL-4, IL-5, and IL-13, compared with the vehicle control group. Our findings indicate that exposure to NIV directly enhanced the phosphorylation of ERK1/2, p-38, and JNK, resulting in a significant increase in TNFα production in antigen-presenting cells, which is closely related to the development of atopic dermatitis., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Published
2024
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45. Protecting Group-Free Total Synthesis of (-)-Boscartin H.

Author

Aihara H, Kounai D, Kasamatsu A, Shiraiwa J, Matsuzawa A, Kamo S, and Sugita K

Abstract

Herein, we report the first protecting group-free total synthesis of (-)-boscartin H, which features a 5-12-5-fused tricyclic structure. The key steps, which include a diastereoselective THF-ring-forming/aldol reaction sequence and ring-closing metathesis, afforded high stereoselectivity with (-)-boscartin H obtained in 3.6% overall yield using a 11-step long linear sequence. In addition, X-ray crystallography clearly confirmed the stereochemistry of boscartin H.

Published
2024
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46. Ovarian endometrioma: a report of a pediatric case diagnosed prior to menstruation.

Author

Takada L, Kawano T, Yano K, Iwamoto Y, Ogata M, Kedoin C, Murakami M, Sugita K, Onishi S, Muto M, Kirishima M, Tanimoto A, and Ieiri S

Abstract

Background: Ovarian endometriomas (OEs) are rarely found in the pediatric population, especially before menstruation. We report a 6-year-old girl who was postoperatively diagnosed with OE before menstruation., Case Presentation: A 6-year-old girl presented to a local pediatrician with abdominal pain and vomiting. Abdominal ultrasonography revealed a multilocular cystic lesion to the left of the bladder. Magnetic resonance imaging (MRI) revealed similar findings, with the contents of the cyst showing a low signal on T1-weighted imaging and a high signal on T2-weighted imaging. The patient was referred to our institution for further examination. Enhanced computed tomography (CT) showed a multilocular cystic lesion sized 56 × 44 × 30 mm with partial calcification. The left ovarian vein was dilated, suggesting the origin of the tumor to be the left ovary. Extirpation of the lesion was performed under laparoscopic assistance. Pathological findings indicated an ovarian endometrioma. To our knowledge, this is the youngest report of an OE diagnosed in a patient prior to menstruation., Conclusions: OEs in children before menstruation are extremely rare; thus, the long-term prognosis is yet to be determined., (© 2024. The Author(s).)

Published
2024
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47. Thick Skin on the Dorsal Spine in Osteoproliferative Disease: Ossification of the Posterior Longitudinal Ligament and Diffuse Idiopathic Skeletal Hyperostosis.

Author

Morimoto T, Kobayashi T, Hirata H, Sugita K, Paholpak P, Tsukamoto M, Umeki S, Yoshihara T, and Toda Y

Abstract

Background Although the correlation between reduced skin thickness and reduced bone density has been investigated, no study has evaluated skin thickness and osteoproliferative diseases, including ossification of the posterior longitudinal ligament (OPLL) and diffuse idiopathic skeletal hyperostosis (DISH). Methodology This retrospective cohort study consisted of 99 consecutive patients aged ≥60 years treated for spinal surgery at our hospital between January 2022 and March 2023. Skin thickness was measured at the dorsal side of the cervical, thoracic, and lumbar vertebrae on the sagittal cross-section image of whole-spine CT. Based on the median value, skin thickness was categorized into two groups based on a median thickness of 4 mm. Bone mineral density (BMD) was assessed. The sum of the vertebral body and intervertebral bridging osteophytes of the anterior longitudinal and posterior longitudinal ligament were defined as the OALL index and OPLL index. Serum levels of bone metabolism-related markers, such as tartrate-resistant acid phosphatase type 5b, procollagen I N-propeptide, 25-hydroxyvitamin D, and periostin, were measured. To assess the association between skin thickness and imaging findings, we calculated the adjusted odds ratios, adjusting for age, sex, and body mass index (BMI) and using univariate and multivariate logistic regression analyses. Results No significant differences were found in skin thickness in the three dorsal regions of the cervical, thoracic, and lumbar spine (median = 3.3 mm versus 3.5 mm versus 3.4 mm, p = 0.357) and bone metabolism-related markers. Adjusting for age, sex, and BMI, cervical, thoracic, and lumbar skin thicknesses were related to DISH, the OPLL index, and the OPLL and OPLL index, respectively. Conclusions Skin thickness did not correlate with BMD but with the amount of spinal ossification. A correlation was found between skin thickness and vertebral and intervertebral ossification; vertebral osteophytes, OPLL, and DISH may be more common in thicker skin., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2024, Morimoto et al.)

Published
2024
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48. A multi-center randomized controlled trial to investigate potential effects of exercise therapy on renal function stratified by renal disorders and renal pathology: beneficial or harmful effect in immunoglobulin a nephropathy.

Author

Kimura T, Washida N, Ohtsuki S, Sugita K, Hosoya K, and Uchiyama K

Subjects
Humans, Male, Female, Middle Aged, Adult, Exercise Therapy methods, Renal Insufficiency, Chronic therapy, Renal Insufficiency, Chronic physiopathology, Cystatin C blood, Aged, Creatinine blood, Treatment Outcome, Resistance Training adverse effects, Exercise Tolerance, Proteinuria etiology, Glomerulonephritis, IGA therapy, Glomerulonephritis, IGA physiopathology, Glomerulonephritis, IGA complications, Glomerular Filtration Rate, Kidney physiopathology, Kidney pathology
Abstract

Background: The effects of exercise therapy (ET) on renal function in chronic kidney disease (CKD) remain unclear., Methods: In a randomized controlled trial (UMIN-CTR number: UMIN000038415), we investigated whether ET affects renal function in CKD; eligible patients had undergone renal biopsy in the past 3 months. We stratified patients by disease (immunoglobulin A [IgA] nephropathy, n = 16; diabetic nephropathy, n = 4; benign nephrosclerosis, n = 13; and other CKD types, n = 13) and randomized them to 12 weeks' observation and 24 weeks' ET comprising home-based aerobic exercise 3×/week and resistance training 2×/week (intervention group) or usual care (non-intervention group). Primary endpoint was creatinine-based estimated glomerular filtration rate (eGFR) or serum cystatin C-based eGFR (eGFRcys). Secondary endpoints included urinary protein and exercise tolerance., Results: Seventy patients were enrolled, 50 fulfilled the inclusion criteria, but 4 discontinued before randomization. No items significantly differed between week 0 to 24 in either group (intervention group, n = 23; non-intervention group, n = 23) or between groups at week 24 (intention-to-treat population) in the total study population. The eGFRcys slope showed no significant intergroup difference in the observation period, but eGFRcys improved significantly in IgA nephropathy patients (n = 16) in the intervention group (stratified comparison; week 0, 48.3 ± 18.2; week 24, 51.6 ± 17.6; p = 0.043). In these patients, urinary protein was significantly worse at week 24 in the non-intervention group (p = 0.046) and worsened significantly less in the intervention group (p = 0.039)., Conclusion: ET did not improve renal function overall in CKD patients but might help maintain renal function in patients with IgA nephropathy., (© 2024. The Author(s), under exclusive licence to Japanese Society of Nephrology.)

Published
2024
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49. Clinical outcome and neurological development of patients with biliary atresia associated with a bleeding tendency: a single institution experience.

Author

Masuya R, Muraji T, Harumatsu T, Machigashira S, Iwamoto Y, Ogata M, Takada L, Nishida N, Kedoin C, Nagano A, Matsui M, Murakami M, Sugita K, Yano K, Onishi S, Yamada K, Yamada W, Matsukubo M, Kawano T, Muto M, Nakame K, Kaji T, Nanashima A, and Ieiri S

Subjects
Humans, Infant, Portoenterostomy, Hepatic methods, Retrospective Studies, Treatment Outcome, Liver surgery, Biliary Atresia surgery, Blood Coagulation Disorders etiology
Abstract

Purpose: We compared the clinical features of patients with biliary atresia (BA) associated with a bleeding tendency (BT) at the time of the diagnosis with those of patients without a bleeding tendency (NBT)., Methods: The patients' background characteristics, age in days at the first visit, Kasai portoenterostomy (KPE), and postoperative course were retrospectively analyzed., Results: Nine of the 93 BA patients (9.7%) showed a BT, including 7 with intracranial hemorrhaging (ICH), 1 with gastrointestinal bleeding, and 1 with a prothrombin time (PT) of 0%. The age at the first visit was 62 ± 12 days old for BT patients and 53 ± 27 days old for NBT patients (p = 0.4); the age at KPE was 77 ± 9 days old for BT patients and 65 ± 24 days old for NBT patients (p = 0.2); the time from the first visit to surgery was 13 ± 7 days for BT patients and 11 ± 10 days for NBT patients (p = 0.5); and the native liver survival rate was 56% for BT patients and 58% for NBT patients (p = 1), with no significant difference in any of the parameters. The neurological outcomes of survivors of ICH were favorable., Conclusions: Appropriate BT correction allowed early KPE even after ICH, resulting in native liver survival rates comparable to those of NBT patients without significant neurological complications., (© 2023. The Author(s) under exclusive licence to Springer Nature Singapore Pte Ltd.)

Published
2024
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50. Discovery of Novel 11-Membered Templates as Squalene Synthase Inhibitors.

Author

Haginoya N, Suzuki M, Suzuki M, Ishigai Y, Terayama K, Kanda A, and Sugita K

Subjects
Cricetinae, Animals, Farnesyl-Diphosphate Farnesyltransferase, Enzyme Inhibitors chemistry, Cholesterol, Liver, Anticholesteremic Agents chemistry
Abstract

Squalene synthase is one of the most promising pharmaceutical targets to treat hyperlipidemia. Inhibition of the squalene synthase causes a decrease in the hepatic cholesterol concentration. We have already reported the design and synthesis of highly potent benzhydrol-type squalene inhibitors. Although these templates showed unique and potent cyclic active conformations via intramolecular hydrogen bonds, the in vivo cholesterol-lowering efficacy was insufficient. We attempted to improve their potential as an orally active medicine. In our medicinal chemistry effort, cyclized 11-membered ring templates were acquired. The novel series of compounds exhibited potent squalene synthase inhibitory activity, and one of the derivatives, isomer A -( 1 S , 3 R )- 14i , showed plasma lipid-lowering efficacy in hamster and marmoset repeated-dose studies. Our findings provide valuable insights into the design and development of novel and unique 11-membered ring-type highly potent squalene synthase inhibitors.

Published
2024
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