4-HNE-INDUCED INNATE IMMUNE RESPONSES INFLUENCE ANTI-CARCINOGENESIS IN ROS-OVERPRODUCED MODEL MICE

Mitochondrial reactive oxygen species (ROS) which are mainly generated as an uncoupled consequence of electron transport cause the cellular and organismal oxidative stress. It has been previously demonstrated that the excessive mitochondrial ROS production caused by mitochondrial complex II SDHC mutation results in premature death in C. elegans mev-1 mutant (G71E) and D. melanogaster mev-1-mimic transgenic flies (I71E), and excessive apoptosis and tumorigenesis in mouse embryonic fibroblast SDHC E69 cells (V69E) (M. Tsuda, et al. BBRC 2007, T. Ishii, et al. Cancer Res. 2005, N. Ishii, et al. Nature 1998).