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A strong economical link has arisen between stock markets and exchange rates as a consequence of increased capital flows between international financial markets. This correlation between stock returns and exchange rates is particularly intriguing for developing countries such as Kazakhstan, whose economies are quite sensitive to capital flows. In the evolving global financial system, comprehension of the correlation between exchange rates and stock prices is vital for policymakers and investors. Knowing this relationship enables the manager to manage risk effectively, contrariwise, it is applied by investors to predict future trends. However, economic and financial policymakers and regulators need to know the interrelation between conversion rate and asset prices, such as stock markets, in order to articulate respective policies. Nevertheless, there are plenty of empirical studies on the interrelation between exchange rates and the stock market in developed and developing countries. This correlation has not been explored in Kazakhstan. The purpose of this study is to explore the correlation between stock prices and exchange rates in Kazakhstan. The relationship between the variables was analyzed via Johansen Cointegration Test and the VECM model. Upon the results of the analysis, the presence of a long-term correlation between the variables is proved. According to the results of the causality test, the Granger exchange rate is the reason for stock prices in Kazakhstan. There is no causality from stock prices to exchange rates. The results of the study also have a guiding quality in guiding investment decisions for both equity market and foreign money exchange market investors.The null hypothesis that there is nocointegration connection between the variablesis rejected, according to the Trace and MaximumEigenvalue test data in Table 4. In other words,it has been established that the variables have along-term connection. Granger causality test basedon VAR model cannot be used when there is acointegration connection. The VECM (6) modelwill be estimated first, followed by the causalitytest. The results of the causality test predicted usingthe error correction model are presented in Table 5.The exchange rate is the Granger cause of stockprices in Kazakhstan, according to the findings ofthe causality test. There is no relationship betweenstock prices and currency rates.

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As the amount of data generated in various distributed environments is rapidly increasing, cloud servers and computing technologies are attracting considerable attention. However, the cloud server has privacy issues, including personal information and requires the help of a Trusted Third Party (TTP) for data sharing. However, because the amount of data generated and value increases, the data owner who produces data must become the subject of data sharing. In this study, we use key aggregate searchable encryption (KASE) technology, which enables keyword search, to efficiently share data without using TTP. The traditional KASE scheme approach only discusses delegation of authority from the data owner to another user. However, if the delegated entity cannot perform time-critical tasks because the shared data are unavailable, the delegate must further delegate the rights given to other users. Consequently, this paper proposes a new KASE scheme that enables multi-delegation without TTP and includes an authentication technique between the user and the server. After that, we perform informal and formal analysis using BAN logic and AVISPA for security evaluation, and compare the security and performance aspects with existing schemes. [ABSTRACT FROM AUTHOR]

Neuroinflammation is a key component of epileptogenesis, the process leading to acquired epilepsy. In recent years, with the development of non-invasive in vivo positron emission tomography (PET) imaging of translocator protein 18 kDa (TSPO), a marker of neuroinflammation, it has become possible to perform longitudinal studies to characterize neuroinflammation at different disease stages in animal models of epileptogenesis. This study aimed to utilize the prognostic capability of TSPO PET imaging at disease onset (2 weeks post-SE) to categorize epileptic rats with distinct seizure burden based on TSPO levels at disease onset and investigate their association to TSPO expression at the chronic epilepsy stage. Controls (n = 14) and kainic acid-induced status epilepticus (KASE) rats (n = 41) were scanned non-invasively with [18F]PBR111 PET imaging measuring TSPO expression. Animals were monitored using video-electroencephalography (vEEG) up to chronic disease (12 weeks post-SE), at which TSPO levels ([3H]PK11195) as well as other post-mortem abnormalities (namely synaptic density ([3H]UCB-J), neuronal loss (NeuN), and neurodegeneration (FjC)) were investigated. By applying multivariate analysis, TSPO PET imaging at disease onset identified three KASE groups with significantly different spontaneous recurrent seizures (SRS) burden (defined as rare SRS, sporadic SRS, and frequent SRS) (p = 0.003). Interestingly, TSPO levels were significantly different when comparing the three KASE groups (p

As the amount of data generated in various distributed environments is rapidly increasing, cloud servers and computing technologies are attracting considerable attention. However, the cloud server has privacy issues, including personal information and requires the help of a Trusted Third Party (TTP) for data sharing. However, because the amount of data generated and value increases, the data owner who produces data must become the subject of data sharing. In this study, we use key aggregate searchable encryption (KASE) technology, which enables keyword search, to efficiently share data without using TTP. The traditional KASE scheme approach only discusses delegation of authority from the data owner to another user. However, if the delegated entity cannot perform time-critical tasks because the shared data are unavailable, the delegate must further delegate the rights given to other users. Consequently, this paper proposes a new KASE scheme that enables multi-delegation without TTP and includes an authentication technique between the user and the server. After that, we perform informal and formal analysis using BAN logic and AVISPA for security evaluation, and compare the security and performance aspects with existing schemes.

Purpose: [18F]UCB-H is a specific positron emission tomography (PET) biomarker for the Synaptic Vesicle protein 2A (SV2A), the binding site of the antiepileptic drug levetiracetam. With a view to optimising acquisition time and simplifying data analysis with this radiotracer, we compared two parameters: the distribution volume (Vt) obtained from Logan graphical analysis using a Population-Based Input Function, and the Standardised Uptake Value (SUV).Procedures: Twelve Sprague Dawley male rats, pre-treated with three different doses of levetiracetam were employed to develop the methodology. Three additional kainic acid (KA) treated rats (temporal lobe epilepsy model) were also used to test the procedure. Image analyses focused on: (i) length of the dynamic acquisition (90 versus 60 min); (ii) correlations between Vt and SUV over 20-min consecutive time-frames; (iii) and (iv) evaluation of differences between groups using the Vt and the SUV; and (v) preliminary evaluation of the methodology in the KA epilepsy model.Results: A large correlation between the Vt issued from 60 to 90-min acquisitions was observed. Further analyses highlighted a large correlation (r > 0.8) between the Vt and the SUV. Equivalent differences between groups were detected for both parameters, especially in the 20-40 and 40-60-min time-frames. The same results were also obtained with the epilepsy model.Conclusions: Our results enable the acquisition setting to be changed from a 90-min dynamic to a 20-min static PET acquisition. According to a better image quality, the 20-40-min time-frame appears optimal. Due to its equivalence to the Vt, the SUV parameter can be considered in order to quantify [18F]UCB-H uptake in the rat brain. This work, therefore, establishes a starting point for the simplification of SV2A in vivo quantification with [18F]UCB-H, and represents a step forward to the clinical application of this PET radiotracer. [ABSTRACT FROM AUTHOR]

This paper presents a general review of Achaemenid bowls, followed by an analysis of diagnostic pottery from Seyitömer Höyük. The bowls named as Achaemenid Bowls were the most popular drinking bowls used in the Persian Empire. Beside the examples, which were generally made of valuable metals like gold, silver and bronze, there are also glass and ceramic imitations of these metal products. Up to the present time, twenty-three sherds have been typologically categorized as Achaemenid bowls. Seventeen of these fragments will be presented and discussed in this study. All these fragments have been grouped based on their fabric color as Red Ware and Gray Ware and belong to shallow and deep types. With the exception of three sherds, which come from the Hellenistic level, all examples have been found in the Achaemenid levels. The usage of these bowls started as early as the 5th century BC at Seyitömer Höyük and continued on into the Hellenistic period. For the time being it is impossible to identify the centre of production for these examples, but their small quantity suggests that they may have been imported from other centres. [ABSTRACT FROM AUTHOR]

Neuroinflammation is a key component of epileptogenesis, the process leading to acquired epilepsy. In recent years, with the development of non-invasive in vivo positron emission tomography (PET) imaging of translocator protein 18 kDa (TSPO), a marker of neuroinflammation, it has become possible to perform longitudinal studies to characterize neuroinflammation at different disease stages in animal models of epileptogenesis. This study aimed to utilize the prognostic capability of TSPO PET imaging at disease onset (2 weeks post-SE) to categorize epileptic rats with distinct seizure burden based on TSPO levels at disease onset and investigate their association to TSPO expression at the chronic epilepsy stage. Controls (n = 14) and kainic acid-induced status epilepticus (KASE) rats (n = 41) were scanned non-invasively with [ 18 F]PBR111 PET imaging measuring TSPO expression. Animals were monitored using video-electroencephalography (vEEG) up to chronic disease (12 weeks post-SE), at which TSPO levels ([ 3 H]PK11195) as well as other post-mortem abnormalities (namely synaptic density ([ 3 H]UCB-J), neuronal loss (NeuN), and neurodegeneration (FjC)) were investigated. By applying multivariate analysis, TSPO PET imaging at disease onset identified three KASE groups with significantly different spontaneous recurrent seizures (SRS) burden (defined as rare SRS, sporadic SRS, and frequent SRS) (p = 0.003). Interestingly, TSPO levels were significantly different when comparing the three KASE groups (p < 0.0001), with the frequent SRS group characterized only by a limited focal TSPO increase at disease onset. On the contrary, TSPO measured during chronic epilepsy was found to be the highest in the frequent SRS group and correlated with seizure burden (r = 0.826, p < 0.0001). Importantly, early and chronic TSPO levels did not correlate (r = -0.05). Finally, significant pathological changes in neuronal loss, synaptic density, and neurodegeneration were found not only when compared to control animals (p < 0.01), but also between the three KASE rat categories in the hippocampus (p < 0.05). Early and chronic TSPO upregulation following epileptogenic insult appear to be driven by two superimposed dynamic processes. The former is associated with epileptogenesis as measured at disease onset, while the latter is related to seizure frequency as quantified during chronic epilepsy., (Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)