1. A Pathoconnectome of Early Neurodegeneration
- Author
-
Kevin Rapp, Alexis R. Houser, James R. Anderson, Crystal Sigulinsky, Hope Morrison, Jessica C. Garcia, Carl B. Watt, Jia-Hui Yang, Daniel Emrich, Rebecca L. Pfeiffer, Jeebika Dahal, Robert E. Marc, and Bryan W. Jones
- Subjects
0303 health sciences ,Neurite sprouting ,Connectomics ,Retina ,Artificial neural network ,Neurodegeneration ,Biology ,medicine.disease ,Network topology ,Photoreceptor degeneration ,3. Good health ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,medicine ,Neuron ,Neuroscience ,030217 neurology & neurosurgery ,030304 developmental biology - Abstract
Connectomics has demonstrated that synaptic networks and their topologies are precise and directly correlate with physiology and behavior. The next extension of connectomics is pathoconnectomics: to map neural network synaptology and circuit topologies corrupted by neurological disease in order to identify robust targets for therapeutics. In this report, we characterize the first pathoconnectome, in this case, generated from a retina with photoreceptor degeneration. We observe aberrant connectivity in the rod-network pathway and novel synaptic connections deriving from neurite sprouting. These observations reveal principles of neuron responses to the loss of network components and can be extended to other neurodegenerative diseases.
- Published
- 2020
- Full Text
- View/download PDF