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A Pathoconnectome of Early Neurodegeneration
- Publication Year :
- 2020
- Publisher :
- Cold Spring Harbor Laboratory, 2020.
-
Abstract
- Connectomics has demonstrated that synaptic networks and their topologies are precise and directly correlate with physiology and behavior. The next extension of connectomics is pathoconnectomics: to map neural network synaptology and circuit topologies corrupted by neurological disease in order to identify robust targets for therapeutics. In this report, we characterize the first pathoconnectome, in this case, generated from a retina with photoreceptor degeneration. We observe aberrant connectivity in the rod-network pathway and novel synaptic connections deriving from neurite sprouting. These observations reveal principles of neuron responses to the loss of network components and can be extended to other neurodegenerative diseases.
- Subjects :
- 0303 health sciences
Neurite sprouting
Connectomics
Retina
Artificial neural network
Neurodegeneration
Biology
medicine.disease
Network topology
Photoreceptor degeneration
3. Good health
03 medical and health sciences
0302 clinical medicine
medicine.anatomical_structure
medicine
Neuron
Neuroscience
030217 neurology & neurosurgery
030304 developmental biology
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....4062bac463abd557b20395ca1ae03430
- Full Text :
- https://doi.org/10.1101/2020.01.31.929265