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2. Prospective evaluation of 92 serum protein biomarkers for early detection of ovarian cancer

Author

Mukama, Trasias, Fortner, Renée Turzanski, Katzke, Verena, Hynes, Lucas Cory, Petrera, Agnese, Hauck, Stefanie M., Johnson, Theron, Schulze, Matthias, Schiborn, Catarina, Rostgaard-Hansen, Agnetha Linn, Tjønneland, Anne, Overvad, Kim, Pérez, María José Sánchez, Crous-Bou, Marta, Chirlaque, María-Dolores, Amiano, Pilar, Ardanaz, Eva, Watts, Eleanor L., Travis, Ruth C., Sacerdote, Carlotta, Grioni, Sara, Masala, Giovanna, Signoriello, Simona, Tumino, Rosario, Gram, Inger T., Sandanger, Torkjel M., Sartor, Hanna, Lundin, Eva, Idahl, Annika, Heath, Alicia K., Dossus, Laure, Weiderpass, Elisabete, and Kaaks, Rudolf

Published
2022
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3. Circulating inflammatory biomarkers, adipokines and breast cancer risk—a case-control study nested within the EPIC cohort

Author

Cairat, Manon, Rinaldi, Sabina, Navionis, Anne-Sophie, Romieu, Isabelle, Biessy, Carine, Viallon, Vivian, Olsen, Anja, Tjønneland, Anne, Fournier, Agnès, Severi, Gianluca, Kvaskoff, Marina, Fortner, Renée T., Kaaks, Rudolf, Aleksandrova, Krasimira, Schulze, Matthias B., Masala, Giovanna, Tumino, Rosario, Sieri, Sabina, Grasso, Chiara, Mattiello, Amalia, Gram, Inger T., Olsen, Karina Standahl, Agudo, Antonio, Etxezarreta, Pilar Amiano, Sánchez, Maria-Jose, Santiuste, Carmen, Barricarte, Aurelio, Monninkhof, Evelyn, Hiensch, Anouk E., Muller, David, Merritt, Melissa A., Travis, Ruth C., Weiderpass, Elisabete, Gunter, Marc J., and Dossus, Laure

Published
2022
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4. Prospective analysis of circulating metabolites and endometrial cancer risk

Author

Dossus, Laure, Kouloura, Eirini, Biessy, Carine, Viallon, Vivian, Siskos, Alexandros P., Dimou, Niki, Rinaldi, Sabina, Merritt, Melissa A., Allen, Naomi, Fortner, Renee, Kaaks, Rudolf, Weiderpass, Elisabete, Gram, Inger T., Rothwell, Joseph A., Lécuyer, Lucie, Severi, Gianluca, Schulze, Matthias B., Nøst, Therese Haugdahl, Crous-Bou, Marta, Sánchez, Maria-Jose, Amiano, Pilar, Colorado-Yohar, Sandra M., Gurrea, Aurelio Barricarte, Schmidt, Julie A., Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Sacerdote, Carlotta, Mattiello, Amalia, Vermeulen, Roel, Heath, Alicia K., Christakoudi, Sofia, Tsilidis, Konstantinos K., Travis, Ruth C., Gunter, Marc J., and Keun, Hector C.

Published
2021
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5. Development and validation of circulating CA125 prediction models in postmenopausal women

Author

Sasamoto, Naoko, Babic, Ana, Rosner, Bernard A., Fortner, Renée T., Vitonis, Allison F., Yamamoto, Hidemi, Fichorova, Raina N., Titus, Linda J., Tjønneland, Anne, Hansen, Louise, Kvaskoff, Marina, Fournier, Agnès, Mancini, Francesca Romana, Boeing, Heiner, Trichopoulou, Antonia, Peppa, Eleni, Karakatsani, Anna, Palli, Domenico, Grioni, Sara, Mattiello, Amalia, Tumino, Rosario, Fiano, Valentina, Onland-Moret, N. Charlotte, Weiderpass, Elisabete, Gram, Inger T., Quirós, J. Ramón, Lujan-Barroso, Leila, Sánchez, Maria-Jose, Colorado-Yohar, Sandra, Barricarte, Aurelio, Amiano, Pilar, Idahl, Annika, Lundin, Eva, Sartor, Hanna, Khaw, Kay-Tee, Key, Timothy J., Muller, David, Riboli, Elio, Gunter, Marc, Dossus, Laure, Trabert, Britton, Wentzensen, Nicolas, Kaaks, Rudolf, Cramer, Daniel W., Tworoger, Shelley S., and Terry, Kathryn L.

Published
2019
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6. An epidemiological model for prediction of endometrial cancer risk in Europe

Author

Hüsing, Anika, Dossus, Laure, Ferrari, Pietro, Tjønneland, Anne, Hansen, Louise, Fagherazzi, Guy, Baglietto, Laura, Schock, Helena, Chang-Claude, Jenny, Boeing, Heiner, Steffen, Annika, Trichopoulou, Antonia, Bamia, Christina, Katsoulis, Michalis, Krogh, Vittorio, Palli, Domenico, Panico, Salvatore, Onland-Moret, N. Charlotte, Peeters, Petra H., Bueno-de-Mesquita, H. Bas, Weiderpass, Elisabete, Gram, Inger T., Ardanaz, Eva, Obón-Santacana, Mireia, Navarro, Carmen, Sánchez-Cantalejo, Emilio, Etxezarreta, Nerea, Allen, Naomi E., Khaw, Kay Tee, Wareham, Nick, Rinaldi, Sabina, Romieu, Isabelle, Merritt, Melissa A., Gunter, Marc, Riboli, Elio, and Kaaks, Rudolf

Published
2016

7. Prediagnostic serum glyceraldehyde‐derived advanced glycation end products and mortality among colorectal cancer patients.

Author

Mao, Ziling, Baker, Jacqueline Roshelli, Takeuchi, Masayoshi, Hyogo, Hideyuki, Tjønneland, Anne, Eriksen, Anne Kirstine, Severi, Gianluca, Rothwell, Joseph, Laouali, Nasser, Katzke, Verena, Kaaks, Rudolf, Schulze, Matthias B., Palli, Domenico, Sieri, Sabina, de Magistris, Maria Santucci, Tumino, Rosario, Sacerdote, Carlotta, Derksen, Jeroen W. G., Gram, Inger T., and Skeie, Guri

Subjects
ADVANCED glycation end-products, COLORECTAL cancer, CANCER patients, PROPORTIONAL hazards models, COLON cancer
Abstract

Glyceraldehyde‐derived advanced glycation end products (glycer‐AGEs) could contribute to colorectal cancer development and progression due to their pro‐oxidative and pro‐inflammatory properties. However, the association of glycer‐AGEs with mortality after colorectal cancer diagnosis has not been previously investigated. Circulating glycer‐AGEs were measured by competitive ELISA. Multivariable Cox proportional hazards models were used to calculate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) for associations of circulating glycer‐AGEs concentrations with CRC‐specific and all‐cause mortality among 1034 colorectal cancer (CRC) cases identified within the European Prospective Investigation into Cancer and Nutrition (EPIC) study between 1993 and 2013. During a mean of 48 months of follow‐up, 529 participants died (409 from CRC). Glycer‐AGEs were statistically significantly positively associated with CRC‐specific (HRQ5 vs Q1 = 1.53, 95% CI: 1.04‐2.25, Ptrend =.002) and all‐cause (HRQ5 vs Q1 = 1.62, 95% CI: 1.16‐2.26, Ptrend <.001) mortality among individuals with CRC. There was suggestion of a stronger association between glycer‐AGEs and CRC‐specific mortality among patients with distal colon cancer (per SD increment: HRproximal colon = 1.02, 95% CI: 0.74‐1.42; HRdistal colon = 1.51, 95% CI: 1.20‐1.91; Peffect modification =.02). The highest HR was observed among CRC cases in the highest body mass index (BMI) and glycer‐AGEs category relative to lowest BMI and glycer‐AGEs category for both CRC‐specific (HR = 1.78, 95% CI: 1.02‐3.01) and all‐cause mortality (HR = 2.15, 95% CI: 1.33‐3.47), although no statistically significant effect modification was observed. Our study found that prediagnostic circulating glycer‐AGEs are positively associated with CRC‐specific and all‐cause mortality among individuals with CRC. Further investigations in other populations and stratifying by tumor location and BMI are warranted. [ABSTRACT FROM AUTHOR]

Published
2023
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9. Endometrial cancer risk prediction including serum‐based biomarkers: results from the EPIC cohort

Author

Fortner, Renée T., Hüsing, Anika, Kühn, Tilman, Konar, Meric, Overvad, Kim, Tjønneland, Anne, Hansen, Louise, BoutronRuault, MarieChristine, Severi, Gianluca, Fournier, Agnès, Boeing, Heiner, Trichopoulou, Antonia, Benetou, Vasiliki, Orfanos, Philippos, Masala, Giovanna, Agnoli, Claudia, Mattiello, Amalia, Tumino, Rosario, Sacerdote, Carlotta, BuenodeMesquita, H.B(as), Peeters, Petra H.M., Weiderpass, Elisabete, Gram, Inger T., Gavrilyuk, Oxana, Quirós, J. Ramón, Maria Huerta, José, Ardanaz, Eva, Larrañaga, Nerea, LujanBarroso, Leila, SánchezCantalejo, Emilio, Butt, Salma Tunå, Borgquist, Signe, Idahl, Annika, Lundin, Eva, Khaw, KayTee, Allen, Naomi E., Rinaldi, Sabina, Dossus, Laure, Gunter, Marc, Merritt, Melissa A., Tzoulaki, Ioanna, Riboli, Elio, and Kaaks, Rudolf

Published
2017
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10. Plasma carotenoids and vitamin C concentrations and risk of urothelial cell carcinoma in the European Prospective Investigation into Cancer and Nutrition

Author

Ros, Martine M, Bueno-de-Mesquita, H Bas, Kampman, Ellen, Aben, Katja KH, Büchner, Frederike L, Jansen, Eugene HJM, van Gils, Carla H, Egevad, Lars, Overvad, Kim, Tjønneland, Anne, Roswall, Nina, Boutron-Ruault, Marie Christine, Kvaskoff, Marina, Perquier, Florence, Kaaks, Rudolf, Chang-Claude, Jenny, Weikert, Steffen, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Dilis, Vardis, Palli, Domenico, Pala, Valeria, Sacerdote, Carlotta, Tumino, Rosario, Panico, Salvatore, Peeters, Petra HM, Gram, Inger T, Skeie, Guri, Huerta, José María, Barricarte, Aurelio, Quirós, José Ramón, Sánchez, María José, Buckland, Genevieve, Larrañaga, Nerea, Ehrnström, Roy, Wallström, Peter, Ljungberg, Börje, Hallmans, Göran, Key, Timothy J, Allen, Naomi E, Khaw, Kay-Tee, Wareham, Nick, Brennan, Paul, Riboli, Elio, and Kiemeney, Lambertus A

Published
2012
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11. Coffee and tea consumption and the risk of ovarian cancer: a prospective cohort study and updated meta-analysis

Author

Braem, Marieke GM, Onland-Moret, N Charlotte, Schouten, Leo J, Tjønneland, Anne, Hansen, Louise, Dahm, Christina C, Overvad, Kim, Lukanova, Annekatrin, Dossus, Laure, Floegel, Anna, Boeing, Heiner, Clavel-Chapelon, Francoise, Chabbert-Buffet, Nathalie, Fagherazzi, Guy, Trichopoulou, Antonia, Benetou, Vassiliki, Goufa, Ioulia, Pala, Valeria, Galasso, Rocco, Mattiello, Amalia, Sacerdote, Carlotta, Palli, Domenico, Tumino, Rosario, Gram, Inger T, Lund, Eiliv, Gavrilyuk, Oxana, Sánchez, Maria-José, Quirós, Ramón, Gonzales, Carlos A, Dorronsoro, Miren, Castaño, José M Huerta, Gurrea, Aurelio Barricarte, Idahl, Annika, Ohlson, Nina, Lundin, Eva, Jirstrom, Karin, Wirfalt, Elisabet, Allen, Naomi E, Tsilidis, Konstantinos K, Kaw, Kay-Tee, Bueno-de-Mesquita, H Bas, Dik, Vincent K, Rinaldi, Sabina, Fedirko, Veronika, Norat, Teresa, Riboli, Elio, Kaaks, Rudolf, and Peeters, Petra HM

Published
2012
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12. Menopausal hormone therapy and risk of ovarian cancer in the European prospective investigation into cancer and nutrition

Author

Tsilidis, Konstantinos K., Allen, Naomi E., Key, Timothy J., Dossus, Laure, Kaaks, Rudolf, Bakken, Kjersti, Lund, Eiliv, Fournier, Agnès, Dahm, Christina C., Overvad, Kim, Hansen, Louise, Tjønneland, Anne, Rinaldi, Sabina, Romieu, Isabelle, Boutron-Ruault, Marie-Christine, Clavel-Chapelon, Francoise, Lukanova, Annekatrin, Boeing, Heiner, Schütze, Madlen, Benetou, Vassiliki, Palli, Domenico, Berrino, Franco, Galasso, Rocco, Tumino, Rosario, Sacerdote, Carlotta, Bueno-de-Mesquita, H. Bas, van Duijnhoven, Fränzel J. B., Braem, Marieke G. M., Onland-Moret, N. Charlotte, Gram, Inger T., Rodríguez, Laudina, Duell, Eric J., Sánchez, María-José, Huerta, José María, Ardanaz, Eva, Amiano, Pilar, Khaw, Kay-Tee, Wareham, Nick, and Riboli, Elio

Published
2011

14. Cigarette Smoking and Colorectal Cancer Risk in the European Prospective Investigation Into Cancer and Nutrition Study

Author

Leufkens, Anke M., Van Duijnhoven, Fränzel J.B., Siersema, Peter D., Boshuizen, Hendriek C., Vrieling, Alina, Agudo, Antonio, Gram, Inger T., Weiderpass, Elisabete, Dahm, Christina, Overvad, Kim, Tjønneland, Anne, Olsen, Anja, Boutron–Ruault, Marie–Christine, Clavel–Chapelon, Françoise, Morois, Sophie, Palli, Domenico, Grioni, Sara, Tumino, Rosario, Sacerdote, Charlotta, Mattiello, Amalia, Herman, Silke, Kaaks, Rudolf, Steffen, Annika, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Peeters, Petra H., van Gils, Carla H., van Kranen, Henk, Lund, Eliv, Dumeaux, Vanessa, Engeset, Dagrun, Rodríguez, Laudina, Sánchez, Maria–José, Chirlaque, Maria–Dolores, Barricarte, Aurelio, Manjer, Jonas, Almquist, Martin, van Guelpen, Bethany, Hallmans, Göran, Khaw, Kay–Tee, Wareham, Nick, Tsilidis, Konstantinos K., Straif, Kurt, Leon–Roux, Maria, Vineis, Paul, Norat, Teresa, Riboli, Elio, and Bueno–de–Mesquita, H. Bas

Published
2011
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15. Factors associated with predictors of smoking cessation from a Norwegian internet-based smoking cessation intervention study.

Author

Gram, Inger T., Antypas, Konstantinos, Wangberg, Silje C., Løchen, Maja-Lisa, and Larbi, Dillys

Subjects
SMOKING cessation, NORWEGIANS, PUBLIC health, QUESTIONNAIRES, INFORMATION retrieval
Abstract

INTRODUCTION We examined if we could identify predictors for smoking cessation at six months post cessation, among smokers enrolled in a large Norwegian populationbased intervention study. METHODS We followed 4333 (72.1% women) smokers who enrolled in an internetbased smoking cessation intervention during 2010-2012. The baseline questionnaire collected information on sociodemographic and lifestyle factors, including current snus use. The cessation outcome was self-reported no smoking past seven days, at six months. We used logistic regression to estimate odds ratios (ORs) with 95% confidence intervals, to identify predictors of smoking cessation, adjusting for potential confounders. RESULTS Women (OR=1.30; 95% CI: 1.01-1.69) compared with men, and those with medium (OR=1.31; 95% CI: 1.02-1.68) and longer (OR=1.42; 95% CI: 1.06-1.90) education compared with those with shorter education, were more likely to be successful quitters. Overall, being a student (OR=0.56; 95% CI: 0.37-0.85) compared with having fulltime work, and a moderate to high Fagerström test for nicotine dependence (FTND) score (OR=0.69; 95% CI: 0.55-0.87) compared with a low score, were predictors for unsuccessful cessation. Current snus use was a predictor for unsuccessful cessation compared to no snus use for both men (OR=0.49; 95% CI: 0.28-0.88) and women (OR=0.49; 95% CI: 0.32-0.75). CONCLUSIONS Our study identifies female sex and longer education as predictors for successful smoking cessation, while a medium or high FTND score, being a student, and current snus use, were predictors for unsuccessful smoking cessation. Only current snus use was a predictor for unsuccessful cessation for both sexes. Our results indicate that smokers should be warned that snus use may prevent successful smoking cessation. [ABSTRACT FROM AUTHOR]

Published
2022
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17. Endogenous androgens and risk of epithelial invasive ovarian cancer by tumor characteristics in the European Prospective Investigation into Cancer and Nutrition

Author

Ose, Jennifer, Fortner, Renée T., Rinaldi, Sabina, Schock, Helena, Overvad, Kim, Tjonneland, Anne, Hansen, Louise, Dossus, Laure, Fournier, Agnes, Baglietto, Laura, Romieu, Isabelle, Kuhn, Elisabetta, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Palli, Domenico, Masala, Giovanna, Sieri, Sabina, Tumino, Rosario, Sacerdote, Carlotta, Mattiello, Amalia, Quiros, Jose Ramon, Obón-Santacana, Mireia, Larrañaga, Nerea, Chirlaque, María-Dolores, Sánchez, María-José, Barricarte, Aurelio, Peeters, Petra H., Bueno-de-Mesquita, H. B(as), Onland-Moret, Charlotte N., Brändstedt, Jenny, Lundin, Eva, Idahl, Annika, Weiderpass, Elisabete, Gram, Inger T., Lund, Eiliv, Kaw, Kay-Tee, Travis, Ruth C., Merritt, Melissa A., Gunther, Marc J., Riboli, Elio, and Kaaks, Rudolf

Published
2015
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18. Long-term weight change and risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Author

Ellingjord-Dale, Merete, Christakoudi, Sofia, Weiderpass, Elisabete, Panico, Salvatore, Dossus, Laure, Olsen, Anja, Tjonneland, Anne, Kaaks, Rudolf, Schulze, Matthias B., Masala, Giovanna, Gram, Inger T., Skeie, Guri, Rosendahl, Ann H., Sund, Malin, Key, Tim, Ferrari, Pietro, Gunter, Marc, Heath, Alicia K., Tsilidis, Konstantinos K., Riboli, Elio, Jose Sanchez, Maria, Chirlaque Lopez, Maria Dolores, Peppa, Eleni, Trichopoulou, Antonia, Martimianaki, Georgia, Agudo, Antonio, Santiuste, Carmen, Ardanaz, Eva, Amiano, Pilar, Boutron-Ruault, Marie-Christine, Simeon, Vittorio, Berrino, Franco, Tumino, Rosario, Severi, Gianluca, Stocks, Tanja, Turzanski-Fortner, Renee, Aleksandrova, Krasimira, Rylander, Charlotta, Aune, Dagfinn, Dahm, Christina C., Department of Surgery, and HUS Abdominal Center

Subjects
0301 basic medicine, Epidemiology, medicine.medical_treatment, Weight Gain, Body Mass Index, 0302 clinical medicine, Risk Factors, Prospective Studies, skin and connective tissue diseases, Public, Environmental & Occupational Health, 2. Zero hunger, Obstetrics, Hazard ratio, 0104 Statistics, Hormone replacement therapy (menopause), General Medicine, Middle Aged, EARLY ADULTHOOD, 3142 Public health care science, environmental and occupational health, 3. Good health, European Prospective Investigation into Cancer and Nutrition, Additional Authors, long-term weight change, POSTMENOPAUSAL WOMEN, 030220 oncology & carcinogenesis, OBESITY, Obesitat, Female, medicine.symptom, Life Sciences & Biomedicine, Cohort study, Adult, medicine.medical_specialty, MENOPAUSE, Breast Neoplasms, SEX STEROIDS, Càncer de mama, 1117 Public Health and Health Services, Young Adult, 03 medical and health sciences, Breast cancer, breast cancer, BODY FATNESS, medicine, cohort study, Humans, AcademicSubjects/MED00860, VALIDITY, Science & Technology, OVERWEIGHT, business.industry, Kirurgi, Weight change, ANTHROPOMETRIC MEASURES, medicine.disease, 030104 developmental biology, Surgery, GAIN, business, Weight gain, Body mass index
Abstract

The coordination of EPIC is financially supported by the European Commission (DG-SANCO) and the International Agency for Research on Cancer. The national cohorts are supported by the Danish Cancer Society (Kræftens Bekæmpelse) (Denmark), German Cancer Aid (Deutsche Krebshilfe), German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), Federal Ministry of Education and Research (Bundesministerium fu¨ r Bildung und Forschung, BMBF) (Germany), Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy and National Research Council (Italy), Swedish Cancer Society (Cancerfonden), Swedish Research Council (Vetenskapsra° det), County Councils of Ska°ne and Va¨sterbotten (Sweden), Cancer Research UK (14136 to EPIC-Norfolk; C570/ A16491 and C8221/A19170 to EPIC-Oxford), Medical Research Council (1000143 to EPIC-Norfolk; MR/M012190/1 to EPICOxford) (UK). Infrastructure support for the Department of Epidemiology and Biostatistics at Imperial College London (UK) was provided by the NIHR Imperial Biomedical Research Centre (BRC). The funders had no role in the design and conduct of the study; the collection, analysis and interpretation of the data; or the preparation, review and approval of the manuscript; or in the decision to submit the manuscript for publication., Background: The role of obesity and weight change in breast-cancer development is complex and incompletely understood. We investigated long-term weight change and breast-cancer risk by body mass index (BMI) at age 20 years, menopausal status, hormone replacement therapy (HRT) and hormone-receptor status. Methods: Using data on weight collected at three different time points from women who participated in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, we investigated the association between weight change from age 20 years until middle adulthood and risk of breast cancer. Results: In total, 150 257 women with a median age of 51 years at cohort entry were followed for an average of 14 years (standard deviation¼3.9) during which 6532 breast-cancer cases occurred. Compared with women with stable weight (62.5 kg), long-term weight gain >10 kg was positively associated with postmenopausal breast-cancer risk in women who were lean at age 20 [hazard ratio (HR)¼1.42; 95% confidence interval 1.22–1.65] in ever HRT users (HR¼1.23; 1.04–1.44), in never HRT users (HR¼1.40; 1.16–1.68) and in oestrogen-and-progesterone-receptor-positive (ERþPRþ) breast cancer (HR¼1.46; 1.15–1.85). Conclusion: Long-term weight gain was positively associated with postmenopausal breast cancer in women who were lean at age 20, both in HRT ever users and non-users, and hormone-receptor-positive breast cancer., European Commission (DG-SANCO), International Agency for Research on Cancer, Danish Cancer Society (Kraftens Bekampelse), German Cancer Aid, German Cancer Research Center, Federal Ministry of Education and Research, Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy and National Research Council, Swedish Cancer Society, Swedish Research Council, County Councils of Skane and Vasterbotten, 14136 Cancer Research UK, C570/A16491 EPIC-Norfolk, 1000143 Medical Research Council, Infrastructure support for the Department of Epidemiology and Biostatistics at Imperial College London (UK) was provided by the NIHR Imperial Biomedical Research Centre (BRC)

Published
2021

19. Cigarette Smoking and Endometrial Cancer Risk: Observational and Mendelian Randomization Analyses.

Author

Dimou, Niki, Omiyale, Wemimo, Biessy, Carine, Viallon, Vivian, Kaaks, Rudolf, O'Mara, Tracy A., Aglago, Elom K., Ardanaz, Eva, Bergmann, Manuela M., Bondonno, Nicola P., Braaten, Tonje, Colorado-Yohar, Sandra M., Crous-Bou, Marta, Dahm, Christina C., Fortner, Renée T., Gram, Inger T., Harlid, Sophia, Heath, Alicia K., Idahl, Annika, and Kvaskoff, Marina

Abstract

Background: Current epidemiologic evidence indicates that smoking is associated with a lower endometrial cancer risk. However, it is unknown if this association is causal or confounded. To further elucidate the role of smoking in endometrial cancer risk, we conducted complementary observational and Mendelian randomization (MR) analyses. Methods: The observational analyses included 286,415 participants enrolled in the European Prospective Investigation into Cancer and Nutrition and 179,271 participants in the UK Biobank, and multivariable Cox proportional hazards models were used. In two-sample MR analyses, genetic variants robustly associated with lifetime amount of smoking (n = 126 variants) and ever having smoked regularly (n = 112 variants) were selected and their association with endometrial cancer risk (12,906 cancer/108,979 controls from the Endometrial Cancer Association Consortium) was examined. Results: In the observational analysis, lifetime amount of smoking and ever having smoked regularly were associated with a lower endometrial cancer risk. In the MR analysis accounting for body mass index, a genetic predisposition to a higher lifetime amount of smoking was not associated with endometrial cancer risk (OR per 1-SD increment: 1.15; 95% confidence interval: 0.91-1.44). Genetic predisposition to ever having smoked regularly was not associated with risk of endometrial cancer. Conclusions: Smoking was inversely associated with endometrial cancer in the observational analyses, although unsupported by the MR. Additional studies are required to better understand the possible confounders and mechanisms underlying the observed associations between smoking and endometrial cancer. [ABSTRACT FROM AUTHOR]

Published
2022
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20. Smoking as a major risk factor for cervical cancer and pre-cancer: Results from the EPIC cohort

Author

Roura, Esther, Castellsagué, Xavier, Pawlita, Michael, Travier, Noémie, Waterboer, Tim, Margall, Núria, Bosch, Xavier F., de Sanjosé, Silvia, Dillner, Joakim, Gram, Inger T., Tjønneland, Anne, Munk, Christian, Pala, Valeria, Palli, Domenico, Khaw, Kay-Tee, Barnabas, Ruanne V., Overvad, Kim, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Fagherazzi, Guy, Kaaks, Rudolf, Lukanova, Annekatrin, Steffen, Annika, Trichopoulou, Antonia, Trichopoulos, Dimitrios, Klinaki, Eleni, Tumino, Rosario, Sacerdote, Carlotta, Panico, Salvatore, Bueno-de-Mesquita, H. B(as), Peeters, Petra H., Lund, Eiliv, Weiderpass, Elisabete, Redondo, Luisa M., Sánchez, María-José, Tormo, Maria-José, Barricarte, Aurelio, Larrañaga, Nerea, Ekström, Johanna, Hortlund, Maria, Lindquist, David, Wareham, Nick, Travis, Ruth C., Rinaldi, Sabina, Tommasino, Massimo, Franceschi, Silvia, and Riboli, Elio

Published
2014
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21. Prospective seroepidemiologic study on the role of Human Papillomavirus and other infections in cervical carcinogenesis: Evidence from the EPIC cohort

Author

Castellsagué, Xavier, Pawlita, Michael, Roura, Esther, Margall, Núria, Waterboer, Tim, Bosch, Xavier F., de Sanjosé, Silvia, Gonzalez, Carlos Alberto, Dillner, Joakim, Gram, Inger T., Tjønneland, Anne, Munk, Christian, Pala, Valeria, Palli, Domenico, Khaw, Kay-Tee, Barnabas, Ruanne V., Overvad, Kim, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Fagherazzi, Guy, Kaaks, Rudolf, Lukanova, Annekatrin, Steffen, Annika, Trichopoulou, Antonia, Trichopoulos, Dimitrios, Klinaki, Eleni, Tumino, Rosario, Sacerdote, Carlotta, Mattiello, Amalia, Bueno-de-Mesquita, H. B(as), Peeters, Petra H., Lund, Eiliv, Weiderpass, Elisabete, Quirós, Ramón J., Sánchez, María-José, Navarro, Carmen, Barricarte, Aurelio, Larrañaga, Nerea, Ekström, Johanna, Hortlund, Maria, Lindquist, David, Wareham, Nick, Travis, Ruth C., Rinaldi, Sabina, Tommasino, Massimo, Franceschi, Silvia, and Riboli, Elio

Published
2014
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22. Active and passive cigarette smoking and breast cancer risk: Results from the EPIC cohort

Author

Dossus, Laure, Boutron-Ruault, Marie-Christine, Kaaks, Rudolf, Gram, Inger T., Vilier, Alice, Fervers, Béatrice, Manjer, Jonas, Tjonneland, Anne, Olsen, Anja, Overvad, Kim, Chang-Claude, Jenny, Boeing, Heiner, Steffen, Annika, Trichopoulou, Antonia, Lagiou, Pagona, Sarantopoulou, Maria, Palli, Domenico, Berrino, Franco, Tumino, Rosario, Vineis, Paolo, Mattiello, Amalia, Bueno-de-Mesquita, Bas H., van Duijnhoven, Franzel J.B., Bakker, Marieke F., Peeters, Petra HM, Weiderpass, Elisabete, Bjerkaas, Eivind, Braaten, Tonje, Menéndez, Virginia, Agudo, Antonio, Sanchez, Maria-Jose, Amiano, Pilar, Tormo, Maria-Jose, Barricarte, Aurelio, Butt, Salma, Khaw, Kay-Tee, Wareham, Nicholas, Key, Tim J., Travis, Ruth C., Rinaldi, Sabina, McCormack, Valerie, Romieu, Isabelle, Cox, David G., Norat, Teresa, Riboli, Elio, and Clavel-Chapelon, Françoise

Published
2014
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23. Cigarette smoking and risk of histological subtypes of epithelial ovarian cancer in the EPIC cohort study

Author

Gram, Inger T., Lukanova, Annekatrin, Brill, Ilene, Braaten, Tonje, Lund, Eiliv, Lundin, Eva, Overvad, Kim, Tjnneland, Anne, Clavel-Chapelon, Francoise, Chabbert-Buffet, Nathalie, Bamia, Christina, Trichopoulou, Antonia, Zylis, Dimosthenis, Masala, Giovanna, Berrino, Franco, Galasso, Rocco, Tumino, Rosario, Sacerdote, Carlotta, Gavrilyuk, Oxana, Kristiansen, Steinar, Rodríguez, Laudina, Bonet, Catalina, Huerta, José María, Barricarte, Aurelio, Sánchez, Maria-José, Dorronsoro, Miren, Jirström, Karin, Almquist, Martin, Idahl, Annika, Bueno-de-Mesquita, Bas H., Braem, Marie, Onland-Moret, Charlotte, Tsilidis, Konstantinos K., Allen, Naomi E., Fedirko, Veronika, Riboli, E., and Kaaks, Rudolf

Published
2012
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24. N-Acetyltransferase 2 Polymorphisms, Tobacco Smoking, and Breast Cancer Risk in the Breast and Prostate Cancer Cohort Consortium

Author

Cox, David G., Dostal, Lucie, Hunter, David J., Le Marchand, Loïc, Hoover, Robert, Ziegler, Regina G., Thun, Michael J., Diver, W. Ryan, Stevens, Victoria L., Amiano, Pilar, Boutron-Rualt, Marie-Christine, Campa, Daniele, van Duijnhoven, Fränzel J. B., Gram, Inger T., Kaaks, Rudolf, Khaw, Kay-Tee, Riboli, Elio, Sund, Malin, Trichopoulos, Demitrios, Tumino, Rosario, Vogel, Ulla, Kraft, Peter, Buring, Julie E., Hankinson, Susan E., Lee, I-Min, Zhang, Shumin M., Lindstrom, Sara, Berg, Christine D., Chanock, Stephen, Isaacs, Claudine, McCarty, Catherine, Haiman, Christopher A., and Henderson, Brian E.

Published
2011
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25. Variety in vegetable and fruit consumption and risk of bladder cancer in the European Prospective Investigation into Cancer and Nutrition

Author

Büchner, Frederike L., Bueno-de-Mesquita, Bas H., Ros, Martine M., Kampman, Ellen, Egevad, Lars, Overvad, Kim, Tjønneland, Anne, Roswall, Nina, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Touillaud, Marina, Kaaks, Rudolf, Chang-Claude, Jenny, Boeing, Heiner, Weikert, Steffen, Trichopoulou, Antonia, Naska, Ada, Benetou, Vicky, Palli, Domenico, Sieri, Sabina, Vineis, Paolo, Tumino, Rosario, Panico, Salvatore, van Duijnhoven, Fränzel J.B., Peeters, Petra H.M., van Gils, Carla H., Lund, Eiliv, Gram, Inger T., Sánchez, Maria-José, Jakszyn, Paula, Larrañaga, Nerea, Ardanaz, Eva, Navarro, Carmen, Rodríguez, Laudina, Manjer, Jonas, Ehrnström, Roy, Hallmans, Göran, Ljungberg, Börje, Key, Tim J., Allen, Naomi E., Khaw, Kay-Tee, Wareham, Nicholas, Slimani, Nadia, Jenab, Mazda, Boffetta, Paolo, Kiemeney, Lambertus A.L.M, and Riboli, Elio

Published
2011
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26. Fluid intake and the risk of urothelial cell carcinomas in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author

Ros, Martine M., Bas Bueno-de-Mesquita, H. B., Büchner, Frederike L., Aben, Katja K.H., Kampman, Ellen, Egevad, Lars, Overvad, Kim, Tjnneland, Anne, Roswall, Nina, Clavel-Chapelon, Francoise, Kaaks, Rudolf, Chang-Claude, Jenny, Boeing, Heiner, Weikert, Steffen, Trichopoulou, Antonia, Orfanos, Philippos, Stasinopulou, Georgia, Saieva, Calogero, Krogh, Vittorio, Vineis, Paolo, Tumino, Rosario, Mattiello, Amalia, Peeters, Petra H.M., van Duijnhoven, Fränzel J.B., Lund, Eiliv, Gram, Inger T, Chirlaque, Maria D, Barricarte, Aurelio, Rodríguez, Laudina, Molina, Esther, Gonzalez, Carlos, Dorronsoro, Miren, Manjer, Jonas, Ehrnström, Roy, Ljungberg, Börje, Allen, Naomi E., Roddam, Andrew W., Khaw, Kay-Tee, Wareham, Nick, Boffetta, Paolo, Slimani, Nadia, Michaud, Dominique S., Kiemeney, Lambertus A.L.M., and Riboli, Elio

Published
2011
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27. Cigarette smoking, environmental tobacco smoke exposure and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition

Author

Vrieling, Alina, Bueno-de-Mesquita, Bas H., Boshuizen, Hendriek C., Michaud, Dominique S., Severinsen, Marianne T., Overvad, Kim, Olsen, Anja, Tjnneland, Anne, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Kaaks, Rudolf, Rohrmann, Sabine, Boeing, Heiner, Nöthlings, Ute, Trichopoulou, Antonia, Moutsiou, Eftihia, Dilis, Vardis, Palli, Domenico, Krogh, Vittorio, Panico, Salvatore, Tumino, Rosario, Vineis, Paolo, van Gils, Carla H., Peeters, Petra H.M., Lund, Eiliv, Gram, Inger T., Rodríguez, Laudina, Agudo, Antonio, Larrañaga, Nerea, Sánchez, María-José, Navarro, Carmen, Barricarte, Aurelio, Manjer, Jonas, Lindkvist, Björn, Sund, Malin, Ye, Weimin, Bingham, Sheila, Khaw, Kay-Tee, Roddam, Andrew, Key, Tim, Boffetta, Paolo, Duell, Eric J., Jenab, Mazda, Gallo, Valentina, and Riboli, Elio

Published
2010
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28. Consumption of vegetables and fruit and the risk of bladder cancer in the European Prospective Investigation into Cancer and Nutrition

Author

Büchner, Frederike L., Bueno-de-Mesquita, Bas H., Ros, Martine M., Kampman, Ellen, Egevad, Lars, Overvad, Kim, Raaschou-Nielsen, Ole, Tjnneland, Anne, Roswall, Nina, Clavel-Chapelon, Francoise, Boutron-Ruault, Marie-Christine, Touillaud, Marina, Chang-Claude, Jenny, Kaaks, Rudolf, Boeing, Heiner, Weikert, Steffen, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Palli, Domenico, Sieri, Sabina, Vineis, Paolo, Tumino, Rosario, Panico, Salvatore, Vrieling, Alina, Peeters, Petra H.M., van Gils, Carla H., Lund, Eiliv, Gram, Inger T., Engeset, Dagrun, Martinez, Carmen, Gonzalez, Carlos A., Larrañaga, Nerea, Ardanaz, Eva, Navarro, Carmen, Rodríguez, Laudina, Manjer, Jonas, Ehrnström, Roy A., Hallmans, Goran, Ljungberg, Borje, Allen, Naomi E., Roddam, Andrew W., Bingham, Sheila, Khaw, Kay-Tee, Slimani, Nadia, Boffetta, Paolo, Jenab, Mazda, Mouw, Traci, Michaud, Dominique S., Kiemeney, Lambertus A.L.M., and Riboli, Elio

Published
2009
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29. The Role of Smoking and Diet in Explaining Educational Inequalities in Lung Cancer Incidence

Author

Menvielle, Gwenn, Boshuizen, Hendriek, Kunst, Anton E., Dalton, Susanne O., Vineis, Paolo, Bergmann, Manuela M., Hermann, Silke, Ferrari, Pietro, Raaschou-Nielsen, Ole, Tjønneland, Anne, Kaaks, Rudolf, Linseisen, Jakob, Kosti, Maria, Trichopoulou, Antonia, Dilis, Vardis, Palli, Domenico, Krogh, Vittorio, Panico, Salvatore, Tumino, Rosario, Büchner, Frederike L., van Gils, Carla H., Peeters, Petra H. M., Braaten, Tonje, Gram, Inger T., Lund, Eiliv, Rodriguez, Laudina, Agudo, Antonio, Sánchez, Maria-José, Tormo, Maria-José, Ardanaz, Eva, Manjer, Jonas, Wirfält, Elisabet, Hallmans, Göran, Rasmuson, Torgny, Bingham, Sheila, Khaw, Kay-Tee, Allen, Naomi, Key, Tim, Boffetta, Paolo, Duell, Eric J., Slimani, Nadia, Gallo, Valentina, Riboli, Elio, and Bueno-de-Mesquita, H. Bas

Published
2009

30. Never-smokers and the fraction of breast cancer attributable to second-hand smoke from parents during childhood: the Norwegian Women and Cancer Study 1991-2018.

Author

Gram, Inger T, Wiik, Arne Bastian, Lund, Eiliv, Licaj, Idlir, and Braaten, Tonje

Subjects
*PROPORTIONAL hazards models, *BREAST cancer, *CANCER patients, *TOBACCO smoke pollution, *SMOKE, *PARENTS, *BREAST, *PASSIVE smoking, *BREAST tumors, *LONGITUDINAL method
Abstract

Background: Second-hand smoke (SHS) is not an established risk factor for breast cancer. We examined exposure to SHS from parents during childhood and breast-cancer risk overall and by oestrogen- and progesterone-receptor status in the Norwegian Women and Cancer Study. Furthermore, we utilized our nationally representative prospective cohort study to estimate the fraction of breast cancer attributable to parental SHS during childhood.Methods: We followed 45 923 never-smoking women, aged 34-70 years, who completed a baseline questionnaire between 1991 and 2007 through linkages to national registries through December 2018. We used Cox proportional-hazards models to estimate age-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs). We estimated the attributable and the population attributable fraction of breast cancer with 95% CIs.Results: During a mean follow-up of 19.8 (6.8) years, 2185 women developed invasive breast cancer, confirmed by histology. Women exposed to SHS from parents during childhood had an 11% higher (95% CI: 1.02-1.22) risk of breast cancer compared with those who were not. No difference was found for oestrogen (Pheterogeneity = 0.31) and progesterone (Pheterogeneity = 0.95) receptor status. For women exposed, the attributable fraction was 10.3% (95% CI: 1.8-18.0), whereas the population attributable fraction of breast cancer was 7.0% (95% CI: 1.0-13.0).Conclusions: Our results suggest that 1 in 14 breast-cancer cases could have been avoided in the absence of SHS exposure from parents during childhood in a population of never-smoking women. The cancer burden attributable to SHS may be underestimated. [ABSTRACT FROM AUTHOR]

Published
2021
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32. Ovarian cancer risk factors by tumor aggressiveness: An analysis from the Ovarian Cancer Cohort Consortium

Author

Fortner, Renee T. Poole, Elizabeth M. Wentzensen, Nicolas A. and Trabert, Britton White, Emily Arslan, Alan A. Patel, V, Alpa and Setiawan, V. Wendy Visvanathan, Kala Weiderpass, Elisabete and Adami, Hans-Olov Black, Amanda Bernstein, Leslie and Brinton, Louise A. Buring, Julie Clendenen, V, Tess and Fournier, Agnes Fraser, Gary Gapstur, Susan M. Gaudet, Mia M. Giles, Graham G. Gram, Inger T. Hartge, Patricia and Hoffman-Bolton, Judith Idahl, Annika Kaaks, Rudolf Kirsh, Victoria A. Knutsen, Synnove Koh, Woon-Puay Lacey, Jr., James V. Lee, I-Min Lundin, Eva Merritt, Melissa A. and Milne, Roger L. Onland-Moret, N. Charlotte Peters, Ulrike and Poynter, Jenny N. Rinaldi, Sabina Robien, Kim Rohan, Thomas and Sanchez, Maria-Jose Schairer, Catherine Schouten, Leo J. and Tjonneland, Anne Townsend, Mary K. Travis, Ruth C. and Trichopoulou, Antonia van den Brandt, Piet A. Vineis, Paolo and Wilkens, Lynne Wolk, Alicja Yang, Hannah P. and Zeleniuch-Jacquotte, Anne Tworoger, Shelley S.

Abstract

Ovarian cancer risk factors differ by histotype; however, within subtype, there is substantial variability in outcomes. We hypothesized that risk factor profiles may influence tumor aggressiveness, defined by time between diagnosis and death, independent of histology. Among 1.3 million women from 21 prospective cohorts, 4,584 invasive epithelial ovarian cancers were identified and classified as highly aggressive (death in = 35 vs. 20 to < 25 kg/m(2), 1.93 [1.46-2.56] and current smoking (vs. never, 1.30 [1.07-1.57]) were associated with increased risk of highly aggressive disease. Results were similar within histotypes. Ovarian cancer risk factors may be directly associated with subtypes defined by tumor aggressiveness, rather than through differential effects on histology. Studies to assess biological pathways are warranted.

Published
2019

34. Fruit and vegetable consumption and lung cancer risk: Updated information from the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author

Linseisen, Jakob, Rohrmann, Sabine, Miller, Anthony B., Bueno-de-Mesquita, Bas H., Büchner, Frederike L., Vineis, Paolo, Agudo, Antonio, Gram, Inger T., Janson, Lars, Krogh, Vittorio, Overvad, Kim, Rasmuson, Torgny, Schulz, Mandy, Pischon, Tobias, Kaaks, Rudolf, Nieters, Alexandra, Allen, Naomi E., Key, Timothy J., Bingham, Sheila, Khaw, Kay-Tee, Amiano, Pilar, Barricarte, Aurelio, Martinez, Carmen, Navarro, Carmen, Quirós, Ramón, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Touvier, Mathilde, Peeters, Petra H.M., Berglund, Göran, Hallmans, Göran, Lund, Eiliv, Palli, Domenico, Panico, Salvatore, Tumino, Rosario, Tjnneland, Anne, Olsen, Anja, Trichopoulou, Antonia, Trichopoulos, Dimitrios, Autier, Philippe, Boffetta, Paolo, Slimani, Nadia, and Riboli, Elio

Published
2007
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36. Smoking Cessation and Short- and Longer-Term Mortality.

Author

Cho, Eo Rin, Brill, Ilene K., Gram, Inger T., Brown, Patrick E., and Jha, Prabhat

Subjects
PREVENTIVE medicine, MORTALITY prevention, SMOKING cessation, DISEASES, DESCRIPTIVE statistics, TUMORS
Abstract

BACKGROUND Smoking cessation reduces mortality and morbidity. However, the extent and rapidity at which cessation reduces contemporary death rates from smoking-related illnesses remain uncertain. METHODS We pooled current or former versus never cigarette smoker hazard ratios from four national cohorts with linkage to death registries in the United States, United Kingdom, Norway, and Canada among adults 20 to 79 years of age from 1974 to 2018. We calculated excess risk differences and survival, comparing current or never smokers with age-specific cessation and cessation fewer than 3, 3 to 9, or 10 or more years earlier. RESULTS Among 1.48 million adults followed for 15 years, 122,697 deaths occurred. Adjusting for age, education, alcohol use, and obesity, current smokers had higher hazard ratios for death compared with never smokers (2.8 for women, 2.7 for men). Survival between 40 and 79 years of age was 12 and 13 years less in women and men, respectively, who smoked compared with never smokers (about 24 to 26 years of life lost for smokers who died from smoking combined with zero loss for smokers who did not die from smoking). Former smokers showed lower hazard ratios (1.3 in both women and men). Short-term cessation for fewer than 3 years was associated with a lower excess risk of 95% in women and 90% in men younger than 40 years of age, with notable beneficial associations also in women and men 40 to 49 years of age (81% and 61%, respectively) and 50 to 59 years of age (63% and 54%, respectively). Cessation at every age was associated with longer survival, particularly cessation before 40 years of age. Among all ages and compared with continued smoking, cessation of fewer than 3 years potentially averted 5 years of life lost and cessation for 10 or more years averted about 10 years of life lost, yielding survival similar to that of never smokers. CONCLUSIONS Quitting smoking at any age, but particularly in younger years, was associated with lower excess mortality overall and from vascular, respiratory, and neoplastic diseases. Beneficial associations were evident as early as 3 years after cessation. (Funded by Canadian Institutes of Health Research [FDN-154277].) [ABSTRACT FROM AUTHOR]

Published
2024
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37. Genotypes and haplotypes in the insulin-like growth factors, their receptors and binding proteins in relation to plasma metabolic levels and mammographic density

Author

Chanock Stephen J, Bremnes Yngve, Fagerheim Toril, Alnaes Grethe IG, Solvang Hiroko K, Johansen Fredrik, Brill Ilene, Gram Inger T, Biong Margarethe, Burdett Laurie, Yeager Meredith, Ursin Giske, and Kristensen Vessela N

Subjects
Internal medicine, RC31-1245, Genetics, QH426-470
Abstract

Abstract Background Increased mammographic density is one of the strongest independent risk factors for breast cancer. It is believed that one third of breast cancers are derived from breasts with more than 50% density. Mammographic density is affected by age, BMI, parity, and genetic predisposition. It is also greatly influenced by hormonal and growth factor changes in a woman's life cycle, spanning from puberty through adult to menopause. Genetic variations in genes coding for hormones and growth factors involved in development of the breast are therefore of great interest. The associations between genetic polymorphisms in genes from the IGF pathway on mammographic density and circulating levels of IGF1, its binding protein IGFBP3, and their ratio in postmenopausal women are reported here. Methods Samples from 964 postmenopausal Norwegian women aged 55-71 years were collected as a part of the Tromsø Mammography and Breast Cancer Study. All samples were genotyped for 25 SNPs in IGF1, IGF2, IGF1R, IGF2R, IGFALS and IGFBP3 using Taqman (ABI). The main statistical analyses were conducted with the PROC HAPLOTYPE procedure within SAS/GENETICS™ (SAS 9.1.3). Results The haplotype analysis revealed six haploblocks within the studied genes. Of those, four had significant associations with circulating levels of IGF1 or IGFBP3 and/or mammographic density. One haplotype variant in the IGF1 gene was found to be associated with mammographic density. Within the IGF2 gene one haplotype variant was associated with levels of both IGF1 and IGFBP3. Two haplotype variants in the IGF2R were associated with the level of IGF1. Both variants of the IGFBP3 haplotype were associated with the IGFBP3 level and indicate regulation in cis. Conclusion Polymorphisms within the IGF1 gene and related genes were associated with plasma levels of IGF1, IGFBP3 and mammographic density in this study of postmenopausal women.

Published
2010
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38. Association of prediagnostic vitamin D status with mortality among colorectal cancer patients differs by common, inherited vitamin D‐binding protein isoforms.

Author

Gibbs, David Corley, Bostick, Roberd M., McCullough, Marjorie L., Um, Caroline Y., Flanders, W. Dana, Jenab, Mazda, Weiderpass, Elisabete, Gylling, Björn, Gram, Inger T., Heath, Alicia K., Colorado‐Yohar, Sandra, Dahm, Christina C., Bueno‐de‐Mesquita, Bas, Perez‐Cornago, Aurora, Trichopoulou, Antonia, Tumino, Rosario, Kühn, Tilman, and Fedirko, Veronika

Subjects
VITAMIN D, COLORECTAL cancer, CANCER patients, VITAMIN D metabolism, CALCITRIOL, VITAMINS
Abstract

Lower prediagnostic circulating 25‐hydroxyvitamin D (25[OH]D)—considered the best marker of total vitamin D exposure—is associated with higher mortality risk among colorectal cancer (CRC) patients. However, it is unknown whether this association differs by the vitamin D‐binding protein (GC) isoform Gc2 (encoded by GC rs4588*C>A, Thr436Lys), which may substantially affect vitamin D metabolism and modify associations of 25(OH)D with colorectal neoplasm risk. Prediagnostic 25(OH)D‐mortality associations according to Gc2 isoform were estimated using multivariable Cox proportional hazards regression among 1281 CRC cases (635 deaths, 483 from CRC) from two large prospective cohorts conducted in the United States (Cancer Prevention Study‐II) and Europe (European Prospective Investigation into Cancer and Nutrition). 25(OH)D measurements were calibrated to a single assay, season standardized, and categorized using Institute of Medicine recommendations (deficient [<30], insufficient [30 ‐ <50], sufficient [≥50 nmol/L]). In the pooled analysis, multivariable‐adjusted hazard ratios (HRs) for CRC‐specific mortality associated with deficient relative to sufficient 25(OH)D concentrations were 2.24 (95% CI 1.44‐3.49) among cases with the Gc2 isoform, and 0.94 (95% CI 0.68‐1.22) among cases without Gc2 (Pinteraction =.0002). The corresponding HRs for all‐cause mortality were 1.80 (95% CI 1.24‐2.60) among those with Gc2, and 1.12 (95% CI 0.84‐1.51) among those without Gc2 (Pinteraction =.004). Our findings suggest that the association of prediagnostic vitamin D status with mortality among CRC patients may differ by functional GC isoforms, and patients who inherit the Gc2 isoform (GC rs4588*A) may particularly benefit from higher circulating 25(OH)D for improved CRC prognosis. What's new? Vitamin D regulates molecular pathways that are relevant to cancer progression. In patients with colorectal cancer (CRC), low serum levels of vitamin D have been associated with increased mortality. A protein called GC binds vitamin D and delivers it to tissues. In this study, the authors found that the increased mortality risk with low vitamin D was only seen in those CRC patients who carry a genetic variant of GC called Gc2. These results may help to identify a vulnerable subgroup of CRC patients, who may particularly benefit from vitamin D supplementation. [ABSTRACT FROM AUTHOR]

Published
2020
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39. Ovarian Cancer Risk Factor Associations by Primary Anatomic Site: The Ovarian Cancer Cohort Consortium.

Author

Fortner, Renée T., Rice, Megan S., Knutsen, Synnove F., Orlich, Michael J., Visvanathan, Kala, Patel, Alpa V., Gaudet, Mia M., Tjønneland, Anne, Kvaskoff, Marina, Kaaks, Rudolf, Trichopolou, Antonia, Pala, Valeria, Onland-Moret, N. Charlotte, Gram, Inger T., Amiano, Pilar, Idahl, Annika, Allen, Naomi E., Weiderpass, Elisabete, Poynter, Jenny N., and Robien, Kim

Abstract

Background: Epithelial ovarian, fallopian tube, and primary peritoneal cancers have shared developmental pathways. Few studies have prospectively examined heterogeneity in risk factor associations across these three anatomic sites. Methods: We identified 3,738 ovarian, 337 peritoneal, and 176 fallopian tube incident cancer cases in 891,731 women from 15 prospective cohorts in the Ovarian Cancer Cohort Consortium. Associations between 18 putative risk factors and risk of ovarian, peritoneal, and fallopian tube cancer, overall and for serous and high-grade serous tumors, were evaluated using competing risks Cox proportional hazards regression. Heterogeneity was assessed by likelihood ratio tests. Results: Most associations did not vary by tumor site (Phet = 0.05). Associations between first pregnancy (Phet = 0.04), tubal ligation (Phet = 0.01), and early-adult (age 18-21 years) body mass index (BMI; Phet = 0.02) and risk differed between ovarian and peritoneal cancers. The association between early-adult BMI and risk further differed between peritoneal and fallopian tube cancer (Phet = 0.03). First pregnancy and tubal ligation were inversely associated with ovarian, but not peritoneal, cancer. Higher early-adult BMI was associated with higher risk of peritoneal, but not ovarian or fallopian tube, cancer. Patterns were generally similar when restricted to serous and high-grade serous cases. Conclusions: Ovarian, fallopian tube, and primary peritoneal cancers appear to have both shared and distinct etiologic pathways, although most risk factors appear to have similar associations by anatomic site. Impact: Further studies on the mechanisms underlying the differences in risk profiles may provide insights regarding the developmental origins of tumors arising in the peritoneal cavity and inform prevention efforts. [ABSTRACT FROM AUTHOR]

Published
2020
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40. Endometrial cancer risk prediction including serum-based biomarkers: results from the EPIC cohort

Author

Fortner, Renee T. Huesing, Anika Kuehn, Tilman Konar, Meric and Overvad, Kim Tjonneland, Anne Hansen, Louise and Boutron-Ruault, Marie-Christine Severi, Gianluca Fournier, Agnes and Boeing, Heiner Trichopoulou, Antonia Benetou, Vasiliki and Orfanos, Philippos Masala, Giovanna Agnoli, Claudia and Mattiello, Amalia Tumino, Rosario Sacerdote, Carlotta and Bueno-de-Mesquita, H. B(as) Peeters, Petra H. M. Weiderpass, Elisabete Gram, Inger T. Gavrilyuk, Oxana Ramon Quiros, J. and Maria Huerta, Jose Ardanaz, Eva Larranaga, Nerea and Lujan-Barroso, Leila Sanchez-Cantalejo, Emilio Butt, Salma Tuna and Borgquist, Signe Idahl, Annika Lundin, Eva Khaw, Kay-Tee and Allen, Naomi E. Rinaldi, Sabina Dossus, Laure Gunter, Marc Merritt, Melissa A. Tzoulaki, Ioanna Riboli, Elio and Kaaks, Rudolf

Abstract

Endometrial cancer risk prediction models including lifestyle, anthropometric and reproductive factors have limited discrimina-tion. Adding biomarker data to these models may improve predictive capacity; to our knowledge, this has not been investigat-ed for endometrial cancer. Using a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, we investigated the improvement in discrimination gained by adding serum biomarker concentrations to risk estimates derived from an existing risk prediction model based on epidemiologic factors. Serum concentrations of sex steroid hormones, metabolic markers, growth factors, adipokines and cytokines were evaluated in a step-wise backward selec-tion process; biomarkers were retained at p < 0.157 indicating improvement in the Akaike information criterion (AIC). Improvement in discrimination was assessed using the C-statistic for all biomarkers alone, and change in C-statistic from addition of biomarkers to preexisting absolute risk estimates. We used internal validation with bootstrapping (1000-fold) to adjust for over-fitting. Adiponectin, estrone, interleukin-1 receptor antagonist, tumor necrosis factor-alpha and triglycerides were select-ed into the model. After accounting for over-fitting, discrimination was improved by 2.0 percentage points when all evaluated biomarkers were included and 1.7 percentage points in the model including the selected biomarkers. Models including eti-ologic markers on independent pathways and genetic markers may further improve discrimination.

Published
2017

42. Adult weight change and premenopausal breast cancer risk: A prospective pooled analysis of data from 628,463 women.

Author

Schoemaker, Minouk J., Nichols, Hazel B., Wright, Lauren B., Brook, Mark N., Jones, Michael E., O'Brien, Katie M., Adami, Hans‐Olov, Baglietto, Laura, Bernstein, Leslie, Bertrand, Kimberly A., Boutron‐Ruault, Marie‐Christine, Chen, Yu, Connor, Avonne E., Dossus, Laure, Eliassen, A. Heather, Giles, Graham G., Gram, Inger T., Hankinson, Susan E., Kaaks, Rudolf, and Key, Timothy J.

Subjects
BREAST cancer, DATA analysis, BODY size, WEIGHT gain, BODY weight
Abstract

Early‐adulthood body size is strongly inversely associated with risk of premenopausal breast cancer. It is unclear whether subsequent changes in weight affect risk. We pooled individual‐level data from 17 prospective studies to investigate the association of weight change with premenopausal breast cancer risk, considering strata of initial weight, timing of weight change, other breast cancer risk factors and breast cancer subtype. Hazard ratios (HR) and 95% confidence intervals (CI) were obtained using Cox regression. Among 628,463 women, 10,886 were diagnosed with breast cancer before menopause. Models adjusted for initial weight at ages 18–24 years and other breast cancer risk factors showed that weight gain from ages 18–24 to 35–44 or to 45–54 years was inversely associated with breast cancer overall (e.g., HR per 5 kg to ages 45–54: 0.96, 95% CI: 0.95–0.98) and with oestrogen‐receptor(ER)‐positive breast cancer (HR per 5 kg to ages 45–54: 0.96, 95% CI: 0.94–0.98). Weight gain from ages 25–34 was inversely associated with ER‐positive breast cancer only and weight gain from ages 35–44 was not associated with risk. None of these weight gains were associated with ER‐negative breast cancer. Weight loss was not consistently associated with overall or ER‐specific risk after adjusting for initial weight. Weight increase from early‐adulthood to ages 45–54 years is associated with a reduced premenopausal breast cancer risk independently of early‐adulthood weight. Biological explanations are needed to account for these two separate factors. What's new? Body weight in childhood and early adulthood plays a key role in determining premenopausal breast cancer risk but little is conclusively known about how subsequent weight changes affect this risk. Here the authors pooled results from existing studies on weight changes and breast cancer risk including more than 600,000 premenopausal women. The results show that weight gain >10–15 kg from early adulthood on lowers the risk of developing premenopausal breast cancer, providing further evidence of body weight as an important determinant of breast cancer risk. [ABSTRACT FROM AUTHOR]

Published
2020
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43. Menstrual Factors, Reproductive History, Hormone Use, and Urothelial Carcinoma Risk: A Prospective Study in the EPIC Cohort.

Author

Lujan-Barroso, Leila, Botteri, Edoardo, Caini, Saverio, Ljungberg, Börje, Roswall, Nina, Tjønneland, Anne, Bueno-de-Mesquita, Bas, Gram, Inger T., Tumino, Rosario, Kiemeney, Lambertus A., Liedberg, Fredrik, Stocks, Tanja, Gunter, Marc J., Murphy, Neil, Cervenka, Iris, Fournier, Agnès, Kvaskoff, Marina, Häggström, Christel, Overvad, Kim, and Lund, Eiliv

Abstract

Background: Urothelial carcinoma is the predominant (95%) bladder cancer subtype in industrialized nations. Animal and epidemiologic human studies suggest that hormonal factors may influence urothelial carcinoma risk. Methods: We used an analytic cohort of 333,919 women from the European Prospective Investigation into Cancer and Nutrition Cohort. Associations between hormonal factors and incident urothelial carcinoma (overall and by tumor grade, tumor aggressiveness, and non-muscle-invasive urothelial carcinoma) risk were evaluated using Cox proportional hazards models. Results: During a mean of 15 years of follow-up, 529 women developed urothelial carcinoma. In a model including number of full-term pregnancies (FTP), menopausal status, and menopausal hormone therapy (MHT), number of FTP was inversely associated with urothelial carcinoma risk (HR≥5vs1 = 0.48; 0.25-0.90; Ptrend in parous women = 0.010) and MHT use (compared with nonuse) was positively associated with urothelial carcinoma risk (HR = 1.27; 1.03-1.57), but no dose response by years of MHT use was observed. No modification of HRs by smoking status was observed. Finally, sensitivity analyses in never smokers showed similar HR patterns for the number of FTP, while no association between MHT use and urothelial carcinoma risk was observed. Association between MHT use and urothelial carcinoma risk remained significant only in current smokers. No heterogeneity of the risk estimations in the final model was observed by tumor aggressiveness or by tumor grade. A positive association between MTH use and non-muscle-invasive urothelial carcinoma risk was observed. Conclusions: Our results support that increasing the number of FTP may reduce urothelial carcinoma risk. Impact: More detailed studies on parity are needed to understand the possible effects of perinatal hormone changes in urothelial cells. [ABSTRACT FROM AUTHOR]

Published
2020
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44. Smoking-Related Risks of Colorectal Cancer by Anatomical Subsite and Sex.

Author

Gram, Inger T, Park, Song-Yi, Wilkens, Lynne R, Haiman, Christopher A, and Marchand, Loïc Le

Subjects
*ADENOCARCINOMA, *CANCER invasiveness, *COLON (Anatomy), *COLON tumors, *CONFIDENCE intervals, *ETHNIC groups, *LONGITUDINAL method, *MULTIVARIATE analysis, *SEX distribution, *SMOKING, *PROPORTIONAL hazards models, *DESCRIPTIVE statistics, *DISEASE risk factors, RECTUM tumors
Abstract

The purpose of this study was to examine whether the increased risk of colorectal cancer due to cigarette smoking differed by anatomical subsite or sex. We analyzed data from 188,052 participants aged 45–75 years (45% men) who were enrolled in the Multiethnic Cohort Study in 1993–1996. During a mean follow-up period of 16.7 years, we identified 4,879 incident cases of invasive colorectal adenocarcinoma. In multivariate Cox regression models, as compared with never smokers of the same sex, male ever smokers had a 39% higher risk (hazard ratio (HR) = 1.39, 95% confidence interval (CI): 1.16, 1.67) of cancer of the left (distal or descending) colon but not of the right (proximal or ascending) colon (HR = 1.03, 95% CI: 0.89, 1.18), while female ever smokers had a 20% higher risk (HR = 1.20, 95% CI: 1.06, 1.36) of cancer of the right colon but not of the left colon (HR = 0.96, 95% CI: 0.80, 1.15). Compared with male smokers, female smokers had a greater increase in risk of rectal cancer with number of pack-years of smoking (P for heterogeneity = 0.03). Our results suggest that male smokers are at increased risk of left colon cancer and female smokers are at increased risk of right colon cancer. Our study also suggests that females who smoke may have a higher risk of rectal cancer due to smoking than their male counterparts. [ABSTRACT FROM AUTHOR]

Published
2020
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46. An epidemiological model for prediction of endometrial cancer risk in Europe

Author

Huesing, Anika Dossus, Laure Ferrari, Pietro Tjonneland, Anne Hansen, Louise Fagherazzi, Guy Baglietto, Laura and Schock, Helena Chang-Claude, Jenny Boeing, Heiner Steffen, Annika Trichopoulou, Antonia Bamia, Christina Katsoulis, Michalis Krogh, Vittorio Palli, Domenico Panico, Salvatore and Onland-Moret, N. Charlotte Peeters, Petra H. and Bueno-de-Mesquita, H. Bas Weiderpass, Elisabete Gram, Inger T. and Ardanaz, Eva Obon-Santacana, Mireia Navarro, Carmen and Sanchez-Cantalejo, Emilio Etxezarreta, Nerea Allen, Naomi E. and Khaw, Kay Tee Wareham, Nick Rinaldi, Sabina Romieu, Isabelle and Merritt, Melissa A. Gunter, Marc Riboli, Elio Kaaks, Rudolf

Abstract

Endometrial cancer (EC) is the fourth most frequent cancer in women in Europe, and as its incidence is increasing, prevention strategies gain further pertinence. Risk prediction models can be a useful tool for identifying women likely to benefit from targeted prevention measures. On the basis of data from 201,811 women (mostly aged 30-65 years) including 855 incident EC cases from eight countries in the European Prospective Investigation into Cancer and Nutrition cohort, a model to predict EC was developed. A step-wise model selection process was used to select confirmed predictive epidemiologic risk factors. Piece-wise constant hazard rates in 5-year age-intervals were estimated in a cause-specific competing risks model, five-fold-cross-validation was applied for internal validation. Risk factors included in the risk prediction model were body-mass index (BMI), menopausal status, age at menarche and at menopause, oral contraceptive use, overall and by different BMI categories and overall duration of use, parity, age at first full-term pregnancy, duration of menopausal hormone therapy and smoking status (specific for pre, peri- and post-menopausal women). These variables improved the discriminating capacity to predict risk over 5 years from 71 % for a model based on age alone to 77 % (overall C statistic), and the model was well-calibrated (ratio of expected to observed cases = 0.99). Our model could be used for the identification of women at increased risk of EC in Western Europe. To achieve an EC-risk model with general validity, a large-scale cohort-consortium approach would be needed to assess and adjust for population variation.

Published
2016

47. The Influence of Hormonal Factors on the Risk of Developing Cervical Cancer and Pre-Cancer: Results from the EPIC Cohort

Author

Roura, Esther Travier, Noemie Waterboer, Tim de Sanjose, Silvia Bosch, F. Xavier Pawlita, Michael Pala, Valeria and Weiderpass, Elisabete Margall, Nuria Dillner, Joakim Gram, Inger T. Tjonneland, Anne Munk, Christian Palli, Domenico and Khaw, Kay-Tee Overvad, Kim Clavel-Chapelon, Franoise and Mesrine, Sylvie Fournier, Agnes Fortner, Renee T. Ose, Jennifer Steffen, Annika Trichopoulou, Antonia Lagiou, Pagona Orfanos, Philippos Masala, Giovanna Tumino, Rosario and Sacerdote, Carlotta Polidoro, Silvia Mattiello, Amalia and Lund, Eiliv Peeters, Petra H. Bueno-de-Mesquita, H. B(as). and Quiros, J. Ramon Sanchez, Maria-Jose Navarro, Carmen and Barricarte, Aurelio Larranaga, Nerea Ekstrom, Johanna and Lindquist, David Idahl, Annika Travis, Ruth C. Merritt, Melissa A. Gunter, Marc J. Rinaldi, Sabina Tommasino, Massimo Franceschi, Silvia Riboli, Elio Castellsague, Xavier

Abstract

Background In addition to HPV, high parity and hormonal contraceptives have been associated with cervical cancer (CC). However, most of the evidence comes from retrospective case-control studies. The aim of this study is to prospectively evaluate associations between hormonal factors and risk of developing cervical intraepithelial neoplasia grade 3 (CIN3)/carcinoma in situ (CIS) and invasive cervical cancer (ICC). Methods and Findings We followed a cohort of 308,036 women recruited in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study. At enrollment, participants completed a questionnaire and provided serum. After a 9-year median follow-up, 261 ICC and 804 CIN3/CIS cases were reported. In a nested case-control study, the sera from 609 cases and 1,218 matched controls were tested for L1 antibodies against HPV types 11,16,18,31,33,35,45, 52,58, and antibodies against Chlamydia trachomatis and Human herpesvirus 2. Multivariate analyses were performed to estimate hazard ratios (HR), odds ratios (OR) and corresponding 95% confidence intervals (CI). The cohort analysis showed that number of fullterm pregnancies was positively associated with CIN3/CIS risk (p-trend = 0.03). Duration of oral contraceptives use was associated with a significantly increased risk of both CIN3/CIS and ICC (HR = 1.6 and HR = 1.8 respectively for >= 15 years versus never use). Ever use of menopausal hormone therapy was associated with a reduced risk of ICC (HR = 0.5, 95% CI: 0.4-0.8). A non-significant reduced risk of ICC with ever use of intrauterine devices (IUD) was found in the nested case-control analysis (OR = 0.6). Analyses restricted to all cases and HPV seropositive controls yielded similar results, revealing a significant inverse association with IUD for combined CIN3/CIS and ICC (OR = 0.7). Conclusions Even though HPV is the necessary cause of CC, our results suggest that several hormonal factors are risk factors for cervical carcinogenesis. Adherence to current cervical cancer screening guidelines should minimize the increased risk of CC associated with these hormonal risk factors.

Published
2016

48. Combined effects of smoking and HPV16 in oropharyngeal cancer

Author

Anantharaman, Devasena Muller, David C. Lagiou, Pagona and Ahrens, Wolfgang Holcatova, Ivana Merletti, Franco and Kjaerheim, Kristina Polesel, Jerry Simonato, Lorenzo Canova, Cristina Castellsague, Xavier Macfarlane, Tatiana V. Znaor, Ariana Thomson, Peter Robinson, Max Conway, David I. and Healy, Claire M. Tjonneland, Anne Westin, Ulla Ekstrom, Johanna Chang-Claude, Jenny Kaaks, Rudolf Overvad, Kim and Drogan, Dagmar Hallmans, Goran Laurell, Goran and Bueno-de-Mesquita, H. B. Peeters, Petra H. Agudo, Antonio and Larranaga, Nerea Travis, Ruth C. Palli, Domenico Barricarte, Aurelio Trichopoulou, Antonia George, Saitakis Trichopoulos, Dimitrios Ramon Quiros, J. Grioni, Sara Sacerdote, Carlotta and Navarro, Carmen Sanchez, Maria-Jose Tumino, Rosario and Severi, Gianluca Boutron-Ruault, Marie-Christine and Clavel-Chapelon, Francoise Panico, Salvatore Weiderpass, Elisabete Lund, Eiliv Gram, Inger T. Riboli, Elio and Pawlita, Michael Waterboer, Tim Kreimer, Aimee R. Johansson, Mattias Brennan, Paul

Abstract

Background: Although smoking and HPV infection are recognized as important risk factors for oropharyngeal cancer, how their joint exposure impacts on oropharyngeal cancer risk is unclear. Specifically, whether smoking confers any additional risk to HPV-positive oropharyngeal cancer is not understood. Methods: Using HPV serology as a marker of HPV-related cancer, we examined the interaction between smoking and HPV16 in 459 oropharyngeal (and 1445 oral cavity and laryngeal) cancer patients and 3024 control participants from two large European multicentre studies. Odds ratios and credible intervals [CrI], adjusted for potential confounders, were estimated using Bayesian logistic regression. Results: Both smoking [odds ratio (OR [CrI]: 6.82 [4.52, 10.29]) and HPV seropositivity (OR [CrI]: 235.69 [99.95, 555.74]) were independently associated with oropharyngeal cancer. The joint association of smoking and HPV seropositivity was consistent with that expected on the additive scale (synergy index [CrI]: 1.32 [0.51, 3.45]), suggesting they act as independent risk factors for oropharyngeal cancer. Conclusions: Smoking was consistently associated with increase in oropharyngeal cancer risk in models stratified by HPV16 seropositivity. In addition, we report that the prevalence of oropharyngeal cancer increases with smoking for both HPV16-positive and HPV16-negative persons. The impact of smoking on HPV16-positive oropharyngeal cancer highlights the continued need for smoking cessation programmes for primary prevention of head and neck cancer.

Published
2016

49. Investigation of Dietary Factors and Endometrial Cancer Risk Using a Nutrient-wide Association Study Approach in the EPIC and Nurses' Health Study (NHS) and NHSII

Author

Merritt, Melissa A. Tzoulaki, Ioanna Tworoger, Shelley S. De Vivo, Immaculata Hankinson, Susan E. Fernandes, Judy and Tsilidis, Konstantinos K. Weiderpass, Elisabete Tjonneland, Anne and Petersen, Kristina E. N. Dahm, Christina C. Overvad, Kim and Dossus, Laure Boutron-Ruault, Marie-Christine Fagherazzi, Guy and Fortner, Renee T. Kaaks, Rudolf Aleksandrova, Krasimira and Boeing, Heiner Trichopoulou, Antonia Bamia, Christina and Trichopoulos, Dimitrios Palli, Domenico Grioni, Sara Tumino, Rosario Sacerdote, Carlotta Mattiello, Amalia and Bueno-de-Mesquita, H. B. (as) Onland-Moret, N. Charlotte and Peeters, Petra H. Gram, Inger T. Skeie, Guri Ramon Quiros, J. Duell, Eric J. Sanchez, Maria-Jose Salmeron, D. and Barricarte, Aurelio Chamosa, Saioa Ericson, Ulrica and Sonestedt, Emily Nilsson, Lena Maria Idahl, Annika Khaw, Kay-Tee Wareham, Nicholas Travis, Ruth C. Rinaldi, Sabina and Romieu, Isabelle Patel, Chirag J. Riboli, Elio Gunter, Marc J.

Abstract

Data on the role of dietary factors in endometrial cancer development are limited and inconsistent. We applied a “nutrient-wide association study” approach to systematically evaluate dietary risk associations for endometrial cancer while controlling for multiple hypothesis tests using the false discovery rate (FDR) and validating the results in an independent cohort. We evaluated endometrial cancer risk associations for dietary intake of 84 foods and nutrients based on dietary questionnaires in three prospective studies, the European Prospective Investigation into Cancer and Nutrition (EPIC; N = 1,303 cases) followed by validation of nine foods/nutrients (FDR

Published
2015

50. Endogenous androgens and risk of epithelial invasive ovarian cancer by tumor characteristics in the European Prospective Investigation into Cancer and Nutrition

Author

Ose, Jennifer Fortner, Renee T. Rinaldi, Sabina Schock, Helena Overvad, Kim Tjonneland, Anne Hansen, Louise and Dossus, Laure Fournier, Agnes Baglietto, Laura Romieu, Isabelle Kuhn, Elisabetta Boeing, Heiner Trichopoulou, Antonia Lagiou, Pagona Trichopoulos, Dimitrios Palli, Domenico Masala, Giovanna Sieri, Sabina Tumino, Rosario and Sacerdote, Carlotta Mattiello, Amalia Ramon Quiros, Jose and Obon-Santacana, Mireia Larranaga, Nerea Chirlaque, Maria-Dolores and Sanchez, Maria-Jose Barricarte, Aurelio Peeters, Petra H. and Bueno-de-Mesquita, H. B(as) Onland-Moret, N. Charlotte and Braendstedt, Jenny Lundin, Eva Idahl, Annika Weiderpass, Elisabete Gram, Inger T. Lund, Eiliv Kaw, Kay-Tee and Travis, Ruth C. Merritt, Melissa A. Gunther, Marc J. Riboli, Elio Kaaks, Rudolf

Subjects
endocrine system diseases, female genital diseases and pregnancy complications
Abstract

The role of endogenous androgens and sex hormone-binding globulin (SHBG) in ovarian carcinogenesis is poorly understood. Epithelial invasive ovarian cancer (EOC) is a heterogeneous disease and there are no prospective data on endogenous androgens and EOC risk by tumor characteristics (histology, grade, stage) or the dualistic model of ovarian carcinogenesis (i.e. type I vs. type II, leading to less or more aggressive tumors). We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort evaluating androgens and SHBG and invasive EOC risk by tumor characteristics. Female participants who provided a blood sample and were not using exogenous hormones at blood donation were eligible (n = 183,257). A total of 565 eligible women developed EOC; two controls (n = 1,097) were matched per case. We used multivariable conditional logistic regression models. We observed no association between androgens, SHBG and EOC overall. A doubling of androstenedione reduced risk of serous carcinomas by 21% (odds ratio (OR)log2=0.79, 95% confidence interval [CI]=[0.64-0.97]). Moreover, associations differed for low-grade and high-grade carcinomas, with positive associations for low-grade and inverse associations for high-grade carcinomas (e.g. androstenedione: low grade: ORlog2=1.99 [0.98-4.06]; high grade: ORlog2=0.75 [0.61-0.93], p(het)0.01), similar associations were observed for type I/II tumors. This is the first prospective study to evaluate androgens, SHBG and EOC risk by tumor characteristics and type I/II status. Our findings support a possible role of androgens in ovarian carcinogenesis. Additional studies exploring this association are needed. What’s new? There appear to be several types of epithelial invasive ovarian cancer (EOC), and hormone-related risk factors are poorly understood. In this study, the authors found that the impact of endogenous androgens on the risk of developing EOC differed depending upon tumor characteristics. Androgen concentrations were positively associated with the risk of low-grade and type-I carcinomas, but the study found an inverse association for high-grade tumors. These findings support a possible role for androgens in ovarian carcinogenesis, and emphasize the need for additional research.

Published
2015

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