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Investigation of Dietary Factors and Endometrial Cancer Risk Using a Nutrient-wide Association Study Approach in the EPIC and Nurses' Health Study (NHS) and NHSII

Authors :
Merritt, Melissa A. Tzoulaki, Ioanna Tworoger, Shelley S. De Vivo, Immaculata Hankinson, Susan E. Fernandes, Judy and Tsilidis, Konstantinos K. Weiderpass, Elisabete Tjonneland, Anne and Petersen, Kristina E. N. Dahm, Christina C. Overvad, Kim and Dossus, Laure Boutron-Ruault, Marie-Christine Fagherazzi, Guy and Fortner, Renee T. Kaaks, Rudolf Aleksandrova, Krasimira and Boeing, Heiner Trichopoulou, Antonia Bamia, Christina and Trichopoulos, Dimitrios Palli, Domenico Grioni, Sara Tumino, Rosario Sacerdote, Carlotta Mattiello, Amalia and Bueno-de-Mesquita, H. B. (as) Onland-Moret, N. Charlotte and Peeters, Petra H. Gram, Inger T. Skeie, Guri Ramon Quiros, J. Duell, Eric J. Sanchez, Maria-Jose Salmeron, D. and Barricarte, Aurelio Chamosa, Saioa Ericson, Ulrica and Sonestedt, Emily Nilsson, Lena Maria Idahl, Annika Khaw, Kay-Tee Wareham, Nicholas Travis, Ruth C. Rinaldi, Sabina and Romieu, Isabelle Patel, Chirag J. Riboli, Elio Gunter, Marc J.
Publication Year :
2015

Abstract

Data on the role of dietary factors in endometrial cancer development are limited and inconsistent. We applied a “nutrient-wide association study” approach to systematically evaluate dietary risk associations for endometrial cancer while controlling for multiple hypothesis tests using the false discovery rate (FDR) and validating the results in an independent cohort. We evaluated endometrial cancer risk associations for dietary intake of 84 foods and nutrients based on dietary questionnaires in three prospective studies, the European Prospective Investigation into Cancer and Nutrition (EPIC; N = 1,303 cases) followed by validation of nine foods/nutrients (FDR

Details

Language :
English
Database :
OpenAIRE
Accession number :
edsair.od......2127..a3f947787ccc4bfaf8541de7dc0755d7

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