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4. The need for central and peripheral tolerance in the B cell repertoire.

Author

Goodnow, C.C. and Adelstein, S.

Subjects
*IMMUNITY
Abstract

Describes research into the two phases of the antibody diversity generated within the B cell repertoire. Differences in development of T and B cell repertoires; Self tolerance models in Ig transgenic mice; Specificity for lysozyme; MHC specificity; Tolerance.

Published
1990
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5. Breakdown of self-tolerance in anergic B lymphocytes.

Author

Goodnow, C.C. and Brink, R.

Subjects
*CANCER research
Abstract

Demonstrates that clonal anergy in B lymphocytes is a reversible process, and that silenced self-reactive B cells can be reactivated under particular conditions to give rise to vigorous antibody responses. Methods; Results; Discussion.

Published
1991
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6. Induction of self-tolerance in mature peripheral B lymphocytes.

Author

Goodnow, C.C. and Crosbie, J.

Subjects
*IMMUNITY
Abstract

Describes the use of a transgenic mouse model to follow the fate of self-reactive B cells when they encounter self-antigen only at the mature stage of development, in peripheral lymphoid organs. Low-lysozyme double-transgenic mice; Transfer of nontolerant B cells; Tolerance and IgM-down-regulation in transgenic mice; Discussion.

Published
1989
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