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The need for central and peripheral tolerance in the B cell repertoire.

Authors :
Goodnow, C.C.
Adelstein, S.
Source :
Science. 6/15/1990, Vol. 248 Issue 4961, p1373. 7p. 7 Diagrams, 2 Graphs.
Publication Year :
1990

Abstract

Describes research into the two phases of the antibody diversity generated within the B cell repertoire. Differences in development of T and B cell repertoires; Self tolerance models in Ig transgenic mice; Specificity for lysozyme; MHC specificity; Tolerance.

Subjects

Subjects :
*IMMUNITY

Details

Language :
English
ISSN :
00368075
Volume :
248
Issue :
4961
Database :
Academic Search Index
Journal :
Science
Publication Type :
Academic Journal
Accession number :
9007160234
Full Text :
https://doi.org/10.1126/science.2356469
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