125 results on '"Günhan O"'
Search Results
2. Multiple and familial malignant fibrous histiocytoma of bone. A report of two cases.
- Author
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Finci, R, Günhan, O, Uçmakli, E, and Sarlak, O
- Published
- 1990
3. Peripheral giant cell granuloma associated with dental implants: a rare case report.
- Author
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Özden FO, Özden B, Kurt M, Gündüz K, and Günhan O
- Abstract
The peripheral giant cell granuloma is a benign reactive exophytic lesion of unknown etiology occurring on the gingiva and alveolar ridge. Different local causal factors have been associated with this type of lesion. Although peripheral giant cell granuloma is the most common giant cell lesion of the jaws, it is rarely seen in association with implants. This report discusses the etiology and management of a peripheral giant cell granuloma around dental implants in a 60-year-old woman. A new implant-supported prosthesis with adequate marginal adaptation between the restoration and abutments was made. There were no complications during 1 year of clinical and radiologic follow-up. [ABSTRACT FROM AUTHOR]
- Published
- 2009
4. Postpubertal nonfamilial cherubism and teeth transposition
- Author
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Ozan B., Muğlali M., Celenk P., Günhan O., and Ondokuz Mayıs Üniversitesi
- Abstract
PubMed: 20856051 Cherubism is a rare, nonneoplastic, fibro-osseous disease. It is an autosomal-dominant disorder in which the normal bone is replaced by cellular fibrous tissue and immature bone. It is genetically inherited, although many nonfamilial cases have been reported. Cherubism is a bone disease clinically characterized by bilateral, painless enlargements of the jaws. The mandible is the most severely affected craniofacial component, in which uncontrolled growth of the malady deteriorates the aesthetic balance of the face. A malocclusive and abnormal dentition, worse in the mandible, can be seen. Histopathologically, numerous randomly distributed multinucleated giant cells and vascular spaces within a fibrous connective tissue stroma with or without eosinophilic collagen perivascular cuffing were apparent. The appearance of the affected children is normal at birth. Between the ages of 2 and 7 years, swellings within the mandibular body or tuberosities of maxilla appear. This article relates to a postpubertal nonfamilial cherubism case that was noticed with multiple radiolucencies in radiographic examination and its effects on teeth.
- Published
- 2010
5. Odontogenic tumours. A series of 409 cases.
- Author
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Günhan, Ömer, Erseven, Gülçin, Ruacan, Şevket, Celasun, Bülent, Aydintug, Yavuz, Ergun, Ender, Demiriz, Murat, Günhan, O, Erseven, G, Ruacan, S, Celasun, B, Aydintug, Y, Ergun, E, and Demiriz, M
- Published
- 1990
- Full Text
- View/download PDF
6. Generalized gingival enlargement due to accumulation of amyloid-like material.
- Author
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ÖGünhan, Makoto, Celasun, B., Perrini, F., Covani, U., Perrini, N., Özdemir, A., Bostanci, H., Finci, R., Günhan, O, and Ozdemir, A
- Subjects
AMYLOID ,GINGIVAL diseases ,GINGIVAL hyperplasia ,EPITHELIAL cells ,AMYLOIDOSIS ,CONJUNCTIVITIS ,CYSTS (Pathology) ,STYE ,IMMUNOHISTOCHEMISTRY ,DISEASE complications - Abstract
Hyaline or amyloid-like substances may be seen in several oral lesions. Some of these originate from epithelial cells and some from connective tissue components. In this study, amyloid-like material causing gingival enlargement in three patients, with eyelid involvement in two, was examined using histochemistry, immunohistochemistry and electron microscopy. These accumulations did not share the classical features of amyloid such as green birefringence under polarized light after Congo red staining. Our findings suggest that epithelial degeneration plays an important role in the pathogenesis of these amyloid-like accumulations. These substances may be the result of defective amyloidogenesis and our cases may represent an oral counterpart of ligneous conjunctivitis or colloid milium of the skin. [ABSTRACT FROM AUTHOR]
- Published
- 1994
- Full Text
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7. Examination of periodontal tissues by a cutting-grinding technique.
- Author
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Günhan, Meral, Günhan, Ömer, Celasun, Bülent, Safali, Mükerrem, Günhan, M, Günhan, O, Celasun, B, and Safali, M
- Published
- 1996
- Full Text
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8. A comparative histological study of non-porous and micro-porous (algae-derived) hydroxylapatite ceramics.
- Author
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Günhan, Ömer, Bal, Erol, Celasun, Bülent, Şengün, Onur, Finci, Rifki, Günhan, O, Bal, E, Celasun, B, Sengün, O, and Finci, R
- Published
- 1994
- Full Text
- View/download PDF
9. Ameloblastic fibro-odontoma. Case report.
- Author
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Günhan, Ömer, Celasun, Bülent, Günhan, O, and Celasun, B
- Published
- 1989
- Full Text
- View/download PDF
10. Metastasis of lung adenocarcinoma to the mandible: Report of a case.
- Author
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Misir AF, Mercan U, and Günhan O
- Abstract
Adenocarcinoma of the lung that metastasizes to the mandible is uncommon. There are only a few cases described in the English-language literature regarding metastasis to mandible from adenocarcinoma of the lung. This article shows a metastasis from adenocarcinoma of the lung affecting the mandible of a 55-year-old male patient where the metastatic lesion was detected before primary tumor. This article emphasizes the importance of detailed dentoalveolar examination and early diagnosis for finding the primary focus of metastatic lesions.
- Published
- 2013
- Full Text
- View/download PDF
11. Ex vivo produced oral mucosa equivalent by using the direct explant cell culture technique.
- Author
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Bayar GR, Aydıntuğ YS, Günhan O, Oztürk K, and Gülses A
- Abstract
Objective: The aim of this study is the histological and immunohistochemical evaluation of ex vivo produced oral mucosal equivalents using keratinocytes cultured by direct explant technique., Material and Methods: Oral mucosa tissue samples were obtained from the keratinized gingival tissues of 14 healthy human subjects. Human oral mucosa keratinocytes from an oral mucosa biopsy specimen were dissociated by the explant technique. Once a sufficient population of keratinocytes was reached, they were seeded onto the type IV collagen coated "AlloDerm" and taken for histological and immunohistochemical examinations at 11 days postseeding of the keratinocytes on the cadaveric human dermal matrix., Results: Histopathologically and immunohistochemically, 12 out of 14 successful ex vivo produced oral mucosa equivalents (EVPOME) that consisted of a stratified epidermis on a dermal matrix have been developed with keratinocytes cultured by the explant technique., Conclusion: The technical handling involved in the direct explant method at the beginning of the process has fewer steps than the enzymatic method and use of the direct explant technique protocol for culturing of human oral mucosa keratinocyte may be more adequate for EVPOME production.
- Published
- 2012
- Full Text
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12. The cell with a thousand faces: detection of myoepithelial cells and their contributions in the cytological diagnosis of salivary gland tumors.
- Author
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Avci A, Günhan O, Cakalağaoğlu F, Günal A, and Celasun B
- Subjects
- Adenoma, Pleomorphic pathology, Carcinoma pathology, Carcinoma, Adenoid Cystic pathology, Cell Differentiation, Humans, Epithelial Cells pathology, Myocytes, Smooth Muscle pathology, Salivary Gland Neoplasms pathology
- Abstract
Myoepithelial cells are an important component of salivary gland tumors and are partly responsible from the diverse histology of them. In this study, we focus on the myoepithelial cell differentiation by using cytological morphology in a various types of salivary gland tumors especially with regard to their contribution to the diagnosis. The relation of myoepithelial cells with stromal matrix and the associated epithelial cells were evaluated. Cytologic slides of one hundred and forty one benign and twenty malignant salivary gland tumors were examined for identification of morphologically different myoepithelial cells such as; spindle-stellate, polygonal-epitheloid, plasmacytoid, basal and clear types. The best examples of myoepithelial cells were detected in pleomorphic adenomas, in some monomorphic adenomas and in the adenoid cystic carcinoma cases. Most of the pleomorphic adenomas were composed more than one type of myoepithelial cells and epitheloid-spindle cell combination was frequent. Basal and clear cell types of myoepithelial cells closely resembled the epithelial cells and their identification was relatively difficult. Identification of myoepithelial cell types was easier when they were associated with stromal matrix material and stood as a secondary layer around tubule-forming epithelial cells. Myoepithelial cell components of various salivary gland tumors may be quite different and identification of myoepithelial cell types may pose difficulties. A confident cytologic identification of myoepithelial cells may be critical part of diagnosing salivary gland tumors., (Copyright © 2010 Wiley Periodicals, Inc.)
- Published
- 2012
- Full Text
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13. Reconstruction of a patient with Rosai-Dorfman disease using ramus graft and osseointegrated implants: a case report.
- Author
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Tekin U, Tüz HH, and Günhan O
- Subjects
- Alveolar Ridge Augmentation methods, Dental Implant-Abutment Design, Female, Follow-Up Studies, Humans, Mandible surgery, Tissue and Organ Harvesting methods, Young Adult, Bone Transplantation methods, Dental Implantation, Endosseous methods, Dental Implants, Histiocytosis, Sinus surgery, Mandibular Diseases surgery, Plastic Surgery Procedures methods
- Published
- 2012
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14. Eosinophilic granuloma: resolution of lesion after biopsy.
- Author
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Baş B, Duran H, Şenyurt Ö, and Günhan O
- Subjects
- Biopsy, Child, Eosinophilic Granuloma diagnostic imaging, Eosinophilic Granuloma surgery, Female, Humans, Mandibular Diseases diagnostic imaging, Mandibular Diseases surgery, Radiography, Panoramic, Eosinophilic Granuloma pathology, Mandibular Diseases pathology
- Abstract
Langerhans cell histiocytosis is a collective term used to describe a group of enigmatic proliferative disorders. Three disease variants include eosinophilic granuloma, Letterer-Siwe disease, and Hand-Schuller-Christian syndrome. Eosinophilic granuloma is reported to be the most benign type of the triad. In this report, a 7-year-old child with an eosinophilic granuloma of the left side of her mandible is presented. There was a painless, hard, tender mass arising from the left side of the molar region. Panoramic radiographs showed a radiolucent area at the molar region. The lesion was resolved 2 weeks after the biopsy. The 1.5 years of radiographic and clinical follow-up was satisfactory.
- Published
- 2011
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15. Nasopharyngeal nonkeratinizing (undifferentiated) monstrous cell carcinoma. A case report.
- Author
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Avci A, Günhan O, Karslioğlu Y, and Celasun B
- Subjects
- Aneuploidy, Antigens, Viral metabolism, Biopsy, Capsid Proteins metabolism, Cell Differentiation, Giant Cell Tumors virology, Humans, Male, Middle Aged, Nasopharyngeal Neoplasms virology, Prognosis, Epstein-Barr Virus Infections pathology, Giant Cell Tumors pathology, Herpesvirus 4, Human isolation & purification, Nasopharyngeal Neoplasms pathology
- Abstract
Background: The histologic type of nasopharyngeal carcinoma can be an important factor in the prognosis. The effects, if any, of the degree of cellular pleomorphism is uncertain., Case: In this report, we present a case of nonkeratinizing, undifferentiated nasopharyngeal carcinoma with monstrous tumor giant cells. An extremely high level of aneuploidy and dense cytoplasmic accumulation of Epstein-Barr virus capsid antigen were found in tumor cells. The patient was treated with concomitant chemoradiotherapy., Conclusion: Nine years of follow-up with no recurrences suggests that this extreme morphologic variation may impart no adverse prognostic effect.
- Published
- 2011
16. Histomorphometric analysis of different latency periods effect on new bone obtained by periosteal distraction: an experimental study in the rabbit model.
- Author
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Altuğ HA, Aydintuğ YS, Sençimen M, Günhan O, Ortakoğlu K, Bayar GR, and Doğan N
- Subjects
- Adipose Tissue, Alveolar Ridge Augmentation instrumentation, Animals, Mandible cytology, Osteocytes, Osteogenesis, Distraction instrumentation, Rabbits, Time Factors, Alveolar Ridge Augmentation methods, Bone Regeneration, Mandible surgery, Osteogenesis, Distraction methods, Periosteum surgery
- Abstract
Objectives: The aim of this study was to evaluate the effects of latency period on the bone formation after periosteal distraction. For this purpose, a rabbit model was developed and histologic and histomorphometric analyses were conducted., Study Design: Periosteal distractors were custom designed and built from stainless steel. Rabbits were divided into 2 groups of 18 each according to the duration of latency period. In group 1, the latency period was 7 days, and in group 2 it was 1 day. Distraction was performed by activating the distractor 0.25 mm twice per day. A periosteal distraction of 7.0 mm was achieved after a distraction period of 10 days. Both groups were divided to 3 subgroups according to the rabbits being killed on the 15th, 30th, or 60th day of the consolidation period. Histologic and histomorphometric analyses were performed to evaluate the bone formation., Results: In the histologic evaluation, new bone formation was observed on the lateral side of the mandible of all the rabbits. Histomorphometric measurements revealed that the mean area of newly formed bone formation was 2.62 cm(2) in group 1 and 3.26 cm(2) in group 2., Conclusions: Periosteal distraction osteogenesis is a viable method in acquired and congenital alveolar ridge defects, resulting in new bone formation. Newly formed bone can be obtained by periosteal distraction osteogenesis applying different latency periods., (Copyright © 2011 Mosby, Inc. All rights reserved.)
- Published
- 2011
- Full Text
- View/download PDF
17. Diffuse large B-cell lymphoma with oral manifestations.
- Author
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Bulut E, Bekçioğlu B, Günhan O, and Sener I
- Subjects
- Aged, Biopsy, Fatal Outcome, Humans, Immunohistochemistry, Male, Tomography, X-Ray Computed, Lymphoma, Large B-Cell, Diffuse pathology, Mandibular Neoplasms pathology
- Abstract
Non-Hodgkin lymphomas (NHLs) are a heterogenic group of lymphoproliferative diseases with their different behavior pattern and response to treatments. As a Hodgkin disease, NHL occurs from lymphoid tissues and can spread to other organs. Prognosis depends on histologic type, grade, and treatment. In the World Health Organization classification, aggressive B-cell lymphomas are diffuse large B-cell lymphoma, Burkitt lymphoma/leukemia, and precursor lymphoblastic leukemia/lymphoma. They may present either nodal or extranodal disease, which may be either localized or disseminated. Diffuse large B-cell lymphoma is the most common type of lymphoma in adults and is clinically, morphologically, and genetically a heterogeneous group of malignant proliferations of mature B cells, too. Diffuse large B-cell lymphoma is the most common type of NHL and accounts for about 30% of the cases. In this clinical report, we evaluated clinically and histopathologically a 64-year-old male patient who had mild pain and edema in his mandibular premolar region, and the excisional biopsy showed diffuse large B-cell lymphoma.
- Published
- 2011
- Full Text
- View/download PDF
18. The efficacy of fine needle aspiration cytology in the preoperative evaluation of parakeratotic odontogenic keratocysts.
- Author
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Dereci O, Oztürk A, and Günhan O
- Subjects
- Biopsy, Fine-Needle, Female, Humans, Jaw pathology, Male, Odontogenic Cysts diagnostic imaging, Parakeratosis diagnostic imaging, Radiography, Treatment Outcome, Odontogenic Cysts complications, Odontogenic Cysts pathology, Parakeratosis complications, Parakeratosis pathology, Preoperative Care
- Abstract
Objective: To assess the performance of fine needle aspiration cytology (FNAC) in preoperative diagnosis of parakeratotic odontogenic keratocyst., Study Design: Twenty-three cases of odontogenic keratocyst which were evaluated with FNAC prior to enucleation were included in the study. Aspiration smears were stained with Papanicolaou and hematoxylin-eosin stain. Results obtained from FNAC were compared with histopathologic data obtained from the excisional biopsies., Results: Keratotic cell clusters with or without inflammation were identified in all the cytologic smears. No dysplastic changes were seen. The evaluation of the excisional biopsies revealed cystic epithelium which is characterized by palisaded basal cells, a corrugated surface with a lumen containing keratin debris. Two of the cases which revealed satellite cysts were not associated with Gorlin-Goltz syndrome due to the absence of other findings., Conclusion: Parakeratotic odontogenic keratocyst can be substantially diagnosed preoperatively utilizing FNAC with a careful evaluation., (Copyright © 2011 S. Karger AG, Basel.)
- Published
- 2011
- Full Text
- View/download PDF
19. An unusual presentation of extramedullary plasmacytoma in testis and review of the literature.
- Author
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Turk HM, Komurcu S, Ozet A, Kuzhan O, and Günhan O
- Subjects
- Aged, Diagnosis, Differential, Humans, Male, Multiple Myeloma complications, Multiple Myeloma therapy, Plasmacytoma complications, Plasmacytoma therapy, Prognosis, Radiotherapy Dosage, Testicular Neoplasms complications, Testicular Neoplasms therapy, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Multiple Myeloma diagnosis, Orchiectomy, Plasmacytoma diagnosis, Testicular Neoplasms diagnosis
- Abstract
Extramedullary plasmacytoma is a rare plasma cell neoplasm, and it is extremely uncommon in the testicles. We report a 73-year-old man with multiple myeloma presented with testicular plasmacytoma. He complained of left leg pain and scrotal swelling. Ultrasonography revealed testicular masses. Pathologic examination of the orchiectomy specimen showed plasmocytoma with kappa expression. Multiple lytic bone lesions were seen in bone survey scans, serum immunoelectrophoresis and bone marrow aspiration aided to the diagnosis of multiple myeloma. He received chemotherapy, melphalan and prednisolone, and palliative radiotherapy. He succumbed to disease after 8 months.
- Published
- 2010
- Full Text
- View/download PDF
20. Postpubertal nonfamilial cherubism and teeth transposition.
- Author
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Ozan B, Muğlali M, Celenk P, and Günhan O
- Subjects
- Diagnosis, Differential, Female, Humans, Radiography, Panoramic, Surgical Flaps, Tomography, X-Ray Computed, Young Adult, Cherubism diagnostic imaging, Cherubism surgery, Tooth Abnormalities diagnostic imaging, Tooth Abnormalities surgery
- Abstract
Cherubism is a rare, nonneoplastic, fibro-osseous disease. It is an autosomal-dominant disorder in which the normal bone is replaced by cellular fibrous tissue and immature bone. It is genetically inherited, although many nonfamilial cases have been reported. Cherubism is a bone disease clinically characterized by bilateral, painless enlargements of the jaws. The mandible is the most severely affected craniofacial component, in which uncontrolled growth of the malady deteriorates the aesthetic balance of the face. A malocclusive and abnormal dentition, worse in the mandible, can be seen. Histopathologically, numerous randomly distributed multinucleated giant cells and vascular spaces within a fibrous connective tissue stroma with or without eosinophilic collagen perivascular cuffing were apparent. The appearance of the affected children is normal at birth. Between the ages of 2 and 7 years, swellings within the mandibular body or tuberosities of maxilla appear. This article relates to a postpubertal nonfamilial cherubism case that was noticed with multiple radiolucencies in radiographic examination and its effects on teeth.
- Published
- 2010
- Full Text
- View/download PDF
21. Central osteoma associated with root resorption.
- Author
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Bulut E, Ozan B, and Günhan O
- Subjects
- Biopsy, Diagnosis, Differential, Female, Follow-Up Studies, Humans, Middle Aged, Molar pathology, Radiography, Panoramic, Mandibular Neoplasms complications, Osteoma complications, Root Resorption etiology
- Abstract
Osteomas of the jaws are rare osteogenic lesions considered to be true neoplasms, characterized by the proliferation of compact and/or cancellous bone. It can be central, peripheral, or of an extraskeletal type. The central osteoma arises from the endosteum, the peripheral osteoma from the periosteum, and the extraskeletal soft tissue osteoma usually develops within a muscle. However, in a previous work we have suggested that at least some peripheral osteomas may be reactive rather than neoplasms, probably associated with trauma. Some reported cases did have a clear history of trauma; however, this was not the case in the majority of cases. Whereas peripheral osteomas are fairly easy to diagnose, central osteomas pose a more challenging diagnostic problem and need to be differentiated from other similar lesions of the jaws, such as central ossifying fibroma, condensing osteitis, idiopathic osteosclerosis, osteoblastoma, cementoblastoma, and complex odontoma. With such a low number of case of central osteoma reported, the objectives of the present report are to describe a case of the central osteoma associated with partially root resorption of the mandibular first molar. Our case report participates to literature as a 11th case.
- Published
- 2010
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22. A distinct microvascular pattern accompanied by aggressive clinical course in breast carcinomas: a fact or a coincidence?
- Author
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Safali M, Karslioğlu Y, Arpaci F, Kurt B, and Günhan O
- Subjects
- Adult, Aged, Antigens, CD34 biosynthesis, Breast Neoplasms mortality, Carcinoma, Ductal, Breast mortality, Female, Humans, Image Processing, Computer-Assisted, Immunohistochemistry, Middle Aged, Neovascularization, Pathologic metabolism, Neovascularization, Pathologic pathology, Prognosis, Breast Neoplasms blood supply, Breast Neoplasms pathology, Carcinoma, Ductal, Breast blood supply, Carcinoma, Ductal, Breast pathology
- Abstract
The aim of this study was to evaluate the potential relationship of microvascular growth patterns with survival in invasive breast carcinomas. Thirty-one invasive ductal carcinoma cases, followed up at least for 38 months, constituted our series. All cases had been studied for ER/PR and HER2/neu expression. Clinicopathological and survival data were obtained from the archives. Tissue sections from all cases were stained with CD34 antibody to highlight the microvascular network and to measure microvessel density (MVD). The cases were then classified according to the dominance of one of the five recognizable microvascular patterns. Cox proportional hazard regression model, Fisher's exact test, and multivariate general linear model (GLM) were used to uncover the effects of the variables, such as nodal status, distant metastasis, angiogenic patterns, and MVD, on survival. There was an association between only one of the microvascular patterns and aggressive clinical course. Increased blood-filled capillaries with some clustering in the tumor might be a predictor of aggressive biological behavior in invasive breast carcinomas. Similar studies investigating larger series are needed before a generalized conclusion can be made., (Copyright 2009 Elsevier GmbH. All rights reserved.)
- Published
- 2010
- Full Text
- View/download PDF
23. Treatment of localized Langerhans' cell histiocytosis of the mandible with intralesional steroid injection: report of a case.
- Author
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Esen A, Dolanmaz D, Kalayci A, Günhan O, and Avunduk MC
- Subjects
- Adult, Fractures, Spontaneous diagnostic imaging, Histiocytosis, Langerhans-Cell diagnostic imaging, Histiocytosis, Langerhans-Cell pathology, Humans, Injections, Intralesional, Male, Mandibular Diseases diagnostic imaging, Mandibular Diseases pathology, Mandibular Fractures diagnostic imaging, Radiography, Panoramic, Fractures, Spontaneous drug therapy, Glucocorticoids administration & dosage, Histiocytosis, Langerhans-Cell drug therapy, Mandibular Diseases drug therapy, Mandibular Fractures drug therapy, Methylprednisolone Hemisuccinate administration & dosage
- Abstract
Localized Langerhans cell histiocytosis (LLCH), formerly known as eosinophilic granuloma, mainly affects the skull, mandible, vertebrae, and ribs in children and the long bones of adults. Symptoms range from none to pain, swelling, and tenderness over the site of the lesion. General malaise and fever occasionally are present. Radiographically, lesions appear as radiolucent areas with well demarcated borders. LLCH may resolve spontaneously after biopsy in a period of months to years. However, if features include continuous pain, decrease of function, pathologic fractures, migration and resorption of teeth, or rapid progression, then active treatment needs to be considered. Treatment approaches include surgery, radiotherapy, chemotherapy, and intralesional injection of corticosteroids. In children with mandibular LLCH, 1 dose of methyprednisolone succinate injection has proven to be adequate. However, injections have not been performed in cases involving pathologic fracture. We report a new case of LLCH of the mandible that caused a pathologic fracture in an adult patient. Repeated intralesional corticosteroid injections resulted in fracture line disappearance within 14 months and lesion healing by the end of the 36-month follow-up., (Copyright (c) 2010 Mosby, Inc. All rights reserved.)
- Published
- 2010
- Full Text
- View/download PDF
24. Juvenile hyaline fibromatosis of the mandible with bone involvement: report of a rare case.
- Author
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Altuğ HA, Günal A, Günhan O, and Sençimen M
- Subjects
- Fibroma complications, Humans, Hyalin, Male, Mandibular Neoplasms complications, Tooth, Impacted etiology, Young Adult, Fibroma pathology, Fibromatosis, Gingival pathology, Mandibular Neoplasms pathology
- Abstract
Juvenile hyaline fibromatosis (JHF) is a rare autosomal-recessive hereditary disease, characterized by gingival hypertrophy, flexion contractures of joints, bone lesions, hyaline deposition in the extracellular spaces of the dermis and soft tissues, stunted growth, and skin lesions such as multiple nodules, tumors and pink, pearly papules. No case of JHF with a mandibular bone involvement, exists in the literature. Bone involvement in JHF is an uncommon finding and distinct solitary lesions in the calvarial bones has been reported by some authors. A 21-year-old male patient was referred to Diyarbakir Military Hospital, Department of Dental Service. Clinical findings were consistent with a solid alveolar mass in the right mandibular premolar-molar region and displaced right mandibular molar teeth. Orthopantomographic examination showed impaction of all lower right molars in a mixed radioopaque/radiolucent area. Microscopically, increased nodular connective tissue was seen under the lobulated mucosal surfaces of the resected area. The case presented here had a localized fibrous proliferation that infiltrated bone trabeculae and caused displacement of teeth. Juvenile hyaline fibromatosis should be considered in the differential diagnosis with the other intraosseous radiolucent-patchy opaque lesions of jaw bones. Based on the clinical and histopathological findings, a diagnosis of JHF was made.
- Published
- 2009
- Full Text
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25. Human cytomegalovirus in peripheral giant cell granuloma.
- Author
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Saygun I, Sahin S, Muşabak U, Enhoş S, Kubar A, Günhan O, and Slots J
- Subjects
- Biopsy, CD3 Complex analysis, CD4-Positive T-Lymphocytes pathology, Cuspid pathology, Cytomegalovirus isolation & purification, Cytomegalovirus Infections pathology, Epstein-Barr Virus Infections virology, Female, Gingival Diseases pathology, Granuloma, Giant Cell pathology, Herpesvirus 4, Human isolation & purification, Herpesvirus 4, Human physiology, Humans, Lewis X Antigen analysis, Middle Aged, Neutrophils pathology, Receptors, Interleukin-8A analysis, T-Lymphocytes pathology, Cytomegalovirus physiology, Cytomegalovirus Infections virology, Gingival Diseases virology, Granuloma, Giant Cell virology
- Abstract
Background: The peripheral giant cell granuloma is a relatively common non-neoplastic inflammatory lesion of gingiva, but the etiopathogeny remains unknown. This study aimed to evaluate the importance of human cytomegalovirus and Epstein-Barr virus in a peripheral giant cell granuloma of a 47-year-old female., Methods: The lesion was studied clinically, histopathologically, immunologically and virologically using established procedures., Results: The gingival growth was located at the mesial surface of the maxillary left canine having a vital pulp. The mass was 12 x 21 mm in size and exhibited a smooth surface with no evidence of fluctuation on palpation. An excisional biopsy revealed giant cells in a fibrohistiocytic stroma with areas of haemorrhage. Serum protein levels and lymphocyte subsets were within normal limits, except CD3(+) and CD4(+) cells were below normal ranges. Polymorphonuclear leukocytes expressed p150,95 (CD11c/CD18) and CXCR-2 receptors within normal ranges, but the CXCR1 receptor showed decreased density, and CD15 were below normal range. A virological sample of the tooth surface adjacent to the gingival swelling yielded 7.6 x 10(3) copy-counts of cytomegalovirus and 4.3 x 10(3) copy-counts of Epstein-Barr virus., Conclusions: The clinical and histological findings were consistent with the diagnosis of peripheral giant cell granuloma. Cytomegalovirus has the potential to induce multinucleated giant cells, and the possibility that the virus contribute to the development of peripheral giant cell granuloma merits further study.
- Published
- 2009
- Full Text
- View/download PDF
26. Osseous choristoma of the submandibular region: case report.
- Author
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Kamburoglu K, Ozen T, Sençimen M, Ortakoglu K, and Günhan O
- Subjects
- Adult, Bone and Bones diagnostic imaging, Bone and Bones surgery, Choristoma diagnostic imaging, Choristoma surgery, Female, Humans, Mandibular Injuries complications, Radiography, Panoramic, Submandibular Gland Diseases diagnostic imaging, Submandibular Gland Diseases pathology, Submandibular Gland Diseases surgery, Tomography, X-Ray Computed, Bone and Bones pathology, Choristoma pathology
- Abstract
This report presents a case of osseous choristoma in the submandibular region of a 33-year-old female. Her chief complaint was painless swelling in the submandibular region. Panoramic radiography showed a well-defined, round, radiopaque lesion near the inferior border of the right mandibular angle. Coronal and sagittal tomographic images indicated a high-density area in the right submandibular region with no bony connection. The lesion was diagnosed as an osseous choristoma based on histopathological examination of the surgical specimen. A 1-year follow-up period was uneventful.
- Published
- 2009
- Full Text
- View/download PDF
27. Serous psammocarcinoma of the ovary and peritoneum: two case reports and review of the literature.
- Author
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Alanbay I, Dede M, Ustün Y, Karaşahin E, Deveci S, Günhan O, and Yenen MC
- Subjects
- Adult, Female, Humans, Middle Aged, Carcinoma pathology, Ovarian Neoplasms pathology, Ovary pathology, Peritoneal Neoplasms pathology, Peritoneum pathology
- Abstract
Serous psammocarcinoma (SPC) is a rare variant of ovarian carcinoma or peritoneum that may present with features consistent with malignancy, or tumors of low malignant potential. This is two-case reports of a SPC of the ovary and peritoneum and review of the literature. A 41-year-old woman was referred to our clinic for adnexal mass. Ultrasonography revealed endometrioma. Endometriotic cyst excision and sacrouterine biopsy were performed via laparoscopy. Histological examination revealed endometrioma and psammocarcinoma of the peritoneum. Staging laparotomy was performed. She received six courses of chemotherapy. She has no evidence of disease after 6 years from surgical therapy and chemotherapy. A 50-year-old woman presented with pelvic pain and discomfort in the upper abdomen with nausea and emesis. CT scan showed extensive tumor in the lower abdomen, and free fluid in the abdomen and pelvis which appeared to be an ovarian tumor. She underwent a laparotomy and a right and left ovarian tumor measuring about 20 x 15 and 8 x 8 cm, respectively, were seen. Staging procedure was performed. Microscopic examination revealed SPC of the ovary. Chemotherapy was planned. The biologic behavior of this disease remains unresolved. Primary surgical debulking should be attempted, while the utility of postoperative chemotherapy remains unknown.
- Published
- 2009
- Full Text
- View/download PDF
28. Histomorphometric evaluation of delayed changes in masseter muscle after lengthening the rabbit mandible by distraction osteogenesis.
- Author
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Tüz HH, Dolanmaz D, Pampu AA, Kişnişci RS, and Günhan O
- Subjects
- Animals, Longitudinal Studies, Male, Masseter Muscle physiology, Muscle Fibers, Skeletal cytology, Muscle Fibers, Skeletal physiology, Rabbits, Regeneration, Adaptation, Physiological, Mandible surgery, Mandibular Advancement methods, Masseter Muscle anatomy & histology, Osteogenesis, Distraction methods
- Abstract
Objective: The aim of the study was to evaluate the delayed responses and changes of gradually lengthened masseter muscles of rabbit mandibles., Study Design: Unilateral lengthening of rabbit mandibles was performed in 18 New Zealand rabbits for 7 days at the rate of 1 mm day(-1). Mandibles of animals were removed at months 3, 4, and 6 after distraction. Biopsy samples of distracted and contralateral side masseter muscles were histopathologically evaluated and mean area of muscle fibers (MAF) was evaluated with histomorphometric methods. Results were statistically analyzed., Results: Mild to moderate atrophy of the fibers, and necrosis and myophagocytosis in some areas were the leading features at month 3 and which were decreased at month 4 in distracted side-muscle specimens, with no statistically significant differences when compared with non-distracted side muscles at the same periods. Almost completely, normal fibers were detected in distracted muscle specimens at month 6. Evidence of myopathic changes was found to disappear at month 6 and no significant difference was found in the MAF of distracted side muscles., Conclusion: This study showed that the masseter muscle could adapt to gradual lengthening of the mandible within 6 months. Regenerative features and some degree of atrophic changes that could be observed at months 3 and 4 disappeared at month 6, with adaptation of the fibers.
- Published
- 2009
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29. Concurrent oral and genital involvement in lichen planus.
- Author
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Eralp A, Yüksel N, Kaymak Y, Canbazoğlu M, Ekşioğlu M, and Günhan O
- Subjects
- Adolescent, Adult, Aged, Female, Genital Diseases, Female complications, Genital Diseases, Male complications, Humans, Lichen Planus complications, Lichen Planus diagnosis, Lichen Planus, Oral complications, Male, Middle Aged, Young Adult, Genital Diseases, Female diagnosis, Genital Diseases, Male diagnosis, Lichen Planus, Oral diagnosis
- Published
- 2009
- Full Text
- View/download PDF
30. Effects of hyperbaric oxygen on energy production and xanthine oxidase levels in striated muscle tissue of healthy rats.
- Author
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Kurt B, Kurt Y, Karslioğlu Y, Topal T, Erdamar H, Korkmaz A, Türközkan N, Yaman H, Odabaşi Z, and Günhan O
- Subjects
- Adenosine Monophosphate, Animals, In Vitro Techniques, Male, Rats, Rats, Sprague-Dawley, Succinate Dehydrogenase metabolism, Time Factors, Adenosine Triphosphate metabolism, Hyperbaric Oxygenation, Muscle, Skeletal metabolism, Xanthine Oxidase metabolism
- Abstract
We investigated the effects of hyperbaric oxygen (HBO) treatment on striated muscle tissue in healthy rats. The treatment group of rats (n=16) was given HBO daily on weekdays for 2 h over a 4-week period while a control group (n=8) was not treated. Tissue samples were taken from the left and right vastus lateralis before and after the HBO treatment period, respectively, for all rats in both groups. Levels of adenosine monophosphate (AMP), adenosine diphosphate, andenosine triphosphate (ATP) and xanthine oxidase in the muscle tissue were determined. HBO treatment caused a statistically significant increase in ATP (p=0.001) and decrease in AMP (p=0.02) in the HBO-treated group, while there were no significant differences in metabolites in the control group. These results suggest that HBO treatment induces an increase in the ATP levels of muscle tissue with normal mitochondria. Thus, HBO might have some beneficial effects in the treatment of heteroplasmic mitochondrial disease, where normal and defective mitochondria coexist.
- Published
- 2008
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31. Rosai-Dorfman disease involving maxilla: a case report.
- Author
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Keskin A, Genç F, and Günhan O
- Subjects
- Adult, Diagnosis, Differential, Female, Histiocytosis, Sinus mortality, Histiocytosis, Sinus surgery, Humans, Maxilla diagnostic imaging, Maxilla surgery, Maxillary Diseases diagnostic imaging, Maxillary Diseases surgery, Radiography, Toothache diagnostic imaging, Toothache pathology, Toothache surgery, Histiocytosis, Sinus pathology, Maxilla pathology, Maxillary Diseases pathology
- Published
- 2007
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32. Comparative morphometric analysis of intraepidermal and dermal lymphocytes in early mycosis fungoides and some inflammatory dermatoses.
- Author
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Gamsizkan M, Demiriz M, Karslioğlu Y, and Günhan O
- Subjects
- Adult, Aged, Dermis anatomy & histology, Epidermis anatomy & histology, Female, Humans, Inflammation, Male, Middle Aged, Dermis pathology, Epidermis pathology, Lymphocytes pathology, Mycosis Fungoides pathology, Skin Diseases pathology, Skin Neoplasms pathology
- Abstract
Objective: Early stage mycosis fungoides (MF) may be indistinguishable from some inflammatory dermatoses (IDs) histopathologically. Various morphologic features of lymphocytes in epidermis and dermis may help to differentiate early-stage MF from other IDs., Study Design: We studied 25 cases of early-stage MF and 30 cases of various IDs with prominent exocytosis. The following nuclear variables were measured on dermal and epidermal lymphocytes in MF and IDs (control) groups: nuclear area and perimeter, area convex hull, perimeter convex hull, diameter equivalent circle, minimum feret, maximum feret and form factor. All measurements were done using routinely prepared and hematoxylin-eosin-stained slides., Results: There were statistically significant differences (p < 0.01) for all of the morphometric variables between early-stage MF and IDs., Conclusion: Our results revealed that the nuclear contour irregularities of intraepidermal lymphocytes are higher than those of dermal lymphocytes in MF. Their nuclear geometry is also different. Comparison of the nuclear features of intraepidermal with dermal lymphocytes may provide additional support in the diagnosis of early-stage MF.
- Published
- 2007
33. Eccrine porocarcinoma: a case with an obscure primary tumor diagnosed from lymph node metastasis.
- Author
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Günhan O, Karslioğlu Y, Alömeroğlu M, and Berberoğlu U
- Subjects
- Carcinoma, Skin Appendage complications, Carcinoma, Skin Appendage diagnosis, Carcinoma, Skin Appendage immunology, Cell Proliferation, Chronic Disease, Dermatitis pathology, Eccrine Glands immunology, Female, Humans, Ki-67 Antigen analysis, Lymphatic Metastasis, Middle Aged, Paraneoplastic Syndromes pathology, Prognosis, Sweat Gland Neoplasms complications, Sweat Gland Neoplasms diagnosis, Sweat Gland Neoplasms immunology, Carcinoma, Skin Appendage pathology, Dermatitis etiology, Eccrine Glands pathology, Lymph Nodes pathology, Paraneoplastic Syndromes etiology, Sweat Gland Neoplasms pathology
- Abstract
Eccrine porocarcinoma (EPC), a rare malignant epidermal appendage tumor, is mainly seen in elderly patients. A long history is one of its main characteristics. Two types of EPC are known: juxtaepidermal and dermal. The juxtaepidermal type usually has a more aggressive behavior. Lymph node metastasis and high mitotic activity are associated with poor prognosis. A case of EPC with a long-standing but indolent primary site diagnosed from lymph node metastasis is presented here. There was also accompanying chronic dermatitis as a paraneoplastic syndrome. Diagnosing EPC prior to the regional lymph node involvement is the most valuable factor for a successful treatment. Persistent examinations and attempts to find the primary site(s) have to be made in such cases.
- Published
- 2007
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34. Mandibular involvement of solitary plasmocytoma: a case report.
- Author
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Canger EM, Celenk P, Alkan A, and Günhan O
- Subjects
- Aged, Female, Humans, Mandibular Neoplasms diagnosis, Plasmacytoma diagnosis
- Abstract
Plasma cell neoplasms (multiple myeloma, solitary plasmocytoma of bone and extra medullar plasmocytoma) are characterized by a monoclonal neoplastic proliferation of plasma cells. Solitary plasmocytoma of bone (SPB) is a localized form of them. SPB is most frequently seen in vertebrae and secondarily in long bones. Its presence in jaws is extremely rare and when it is seen, angulus and ramus mandible are most common sites of occurrence. Prognosis of SPB is worse than extra medullar plasmacytoma (EMP) and approximately 50% of SPB will transform to multiple myelom. A 76-year old woman consulted to our clinic with a chief complaint of slowly developed swelling in her mandible. She had an operation from caput femur because of plasmocytoma two months before. Panoramic radiography revealed a radiolucent lesion in the mandibular anterior region, 60x35 mm in dimension. Aspiration biopsy was performed and histopathological examination was reported as plasmocytoma. She was referred to the oncology department for treatment but died before the treatment finished.
- Published
- 2007
35. Co-expression of cyclooxygenase-2 and vascular endothelial growth factor in inflamed human pulp: an immunohistochemical study.
- Author
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Güven G, Altun C, Günhan O, Gurbuz T, Basak F, Akbulut E, and Cehreli ZC
- Subjects
- Adolescent, Adult, Dental Pulp blood supply, Dental Pulp enzymology, Humans, Antigens, CD34 analysis, Cyclooxygenase 2 analysis, Dental Pulp chemistry, Vascular Endothelial Growth Factor A analysis
- Abstract
Recent data from the medical literature indicates that cyclooxygenase-2 (COX-2) plays a key role in the production of vascular endothelial growth factor (VEGF), a glycoprotein that has the ability to increase the permeability of blood vessels and to induce angiogenesis. This study was undertaken to investigate the immunohistological co-expression of COX-2 and VEGF in inflamed human pulp, in conjunction with the expression of CD34, a transmembrane glycoprotein expressed in endothelial cells. Pulp tissue of extracted carious human third molars with a recent history of spontaneous pain were collected and processed for immunostaining of COX-2, VEGF, and CD34 using the biotin-streptoavidin method. Healthy pulp samples served as controls. COX-2 expression was not observed in healthy pulps, whereas all inflamed pulps demonstrated COX-2-expressing cells. Similarly, VEGF was not expressed in normal pulp tissue, but was strongly positive in inflamed pulps. CD34 was expressed in the endothelium of both normal and inflamed pulp tissues. Co-expression of COX-2 and VEGF in all consecutive sections of inflamed pulps could be suggestive of a possible release of VEGF via a COX-2-dependent pathway.
- Published
- 2007
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36. Molecular and clinical spectrum of type I plasminogen deficiency: A series of 50 patients.
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Tefs K, Gueorguieva M, Klammt J, Allen CM, Aktas D, Anlar FY, Aydogdu SD, Brown D, Ciftci E, Contarini P, Dempfle CE, Dostalek M, Eisert S, Gökbuget A, Günhan O, Hidayat AA, Hügle B, Isikoglu M, Irkec M, Joss SK, Klebe S, Kneppo C, Kurtulus I, Mehta RP, Ornek K, Schneppenheim R, Seregard S, Sweeney E, Turtschi S, Veres G, Zeitler P, Ziegler M, and Schuster V
- Subjects
- Animals, Blood Coagulation Disorders genetics, Conjunctivitis etiology, Conjunctivitis genetics, Gene Expression Regulation, Genetic Carrier Screening, Humans, Mice, Mice, Knockout, Plasminogen chemistry, Plasminogen metabolism, Protein Conformation, Plasminogen deficiency, Plasminogen genetics
- Abstract
Severe type I plasminogen (PLG) deficiency has been causally linked to a rare chronic inflammatory disease of the mucous membranes that may be life threatening. Here we report clinical manifestations, PLG plasma levels, and molecular genetic status of the PLG gene of 50 patients. The most common clinical manifestations among these patients were ligneous conjunctivitis (80%) and ligneous gingivitis (34%), followed by less common manifestations such as ligneous vaginitis (8%), and involvement of the respiratory tract (16%), the ears (14%), or the gastrointestinal tract (2%). Four patients showed congenital occlusive hydrocephalus, 2 with Dandy-Walker malformation of cerebellum. Venous thrombosis was not observed. In all patients, plasma PLG levels were markedly reduced. In 38 patients, distinct mutations in the PLG gene were identified. The most common genetic alteration was a K19E mutation found in 34% of patients. Transient in vitro expression of PLG mutants R134K, delK212, R216H, P285T, P285A, T319_N320insN, and R776H in transfected COS-7 cells revealed significantly impaired secretion and increased degradation of PLG. These results demonstrate impaired secretion of mutant PLG proteins as a common molecular pathomechanism in type I PLG deficiency.
- Published
- 2006
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37. The effect of sodium hypochlorite application on the success of calcium hydroxide pulpotomy in primary teeth.
- Author
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Tunç ES, Saroğlu I, Sari S, and Günhan O
- Subjects
- Adolescent, Calcium Hydroxide, Child, Humans, Molar, Tooth, Deciduous, Hemostatics therapeutic use, Pulpotomy methods, Sodium Hypochlorite therapeutic use
- Abstract
Objective: The aim of this study was to evaluate the effects of 3% sodium hypochlorite (NaOCl) used as a hemostatic agent on the outcome of calcium hydroxide pulpotomies of primary teeth., Study Design: A total of 18 primary molars with advanced caries and root resorption of approximately half the root length were randomly placed into 2 groups. Conventional calcium hydroxide pulpotomies were performed on teeth in both groups; however, a cotton pellet saturated with 3% sodium hypochlorite was applied to teeth in the treatment group for 30 seconds before the pulpotomy to control hemorrhage. After the extraction of the teeth, they were examined histologically., Results: In the histologic evaluation it was found that none of the specimens in the control group showed necrosis and 1 specimen in the treatment group showed partial necrosis., Conclusion: It was found that the use of 3% NaOCl as a hemostatic agent had no effect on the outcome of calcium hydroxide pulpotomies with the given concentration and timing of the NaOCl treatment and the given observation period.
- Published
- 2006
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38. A simple method for the evaluation of epidermal thickness variations in psoriasis vulgaris.
- Author
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Demiriz M, Kurumlu Z, Celasun B, and Günhan O
- Subjects
- Biopsy, Follow-Up Studies, Humans, Psoriasis diagnosis, Psoriasis therapy, Retrospective Studies, Sensitivity and Specificity, Epidermis pathology, Image Processing, Computer-Assisted methods, Psoriasis pathology
- Abstract
Objective: To evaluate the "variation" of the epidermal thickness and variables such as the mean, maximum, and minimum thickness for the diagnosis and follow-up of some skin diseases such as psoriasis., Study Design: A simple quantitative method is described. A series of psoriasis vulgaris cases is provided as an example. Biopsy samples taken before and after topical treatment were used., Results: The mean thickness was higher in lesions compared to the perilesional control skin (p < 0.001) and post-treatment lesional area (p < 0.001)., Conclusion: The thickness of the epidermis varies due to a multitude of factors. Measuring the mean epidermal thickness may be important. However, this measurement may not be the best way for studies involving a series of patients and a variety of lesion sites. The natural variations in the thickness of the epidermis of different body sites and of different persons may prevent the usage of thickness measurements alone on a wider scale. It is hoped that this method can be used for evaluation of certain skin diseases affecting epidermal thickness where variation of the epidermal thickness is a potentially useful diagnostic and therapeutic variable.
- Published
- 2006
39. Evaluation of nuclear morphometry and DNA ploidy status for detection of malignant and premalignant oral lesions: quantitative cytologic assessment and review of methods for cytomorphometric measurements.
- Author
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Pektas ZO, Keskin A, Günhan O, and Karslioğlu Y
- Subjects
- Adult, Aged, Biopsy methods, Carcinoma, Squamous Cell genetics, Cell Nucleus pathology, Coloring Agents, DNA, Neoplasm analysis, Early Diagnosis, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Mouth Mucosa pathology, Mouth Neoplasms genetics, Precancerous Conditions genetics, Reproducibility of Results, Rosaniline Dyes, Sensitivity and Specificity, Aneuploidy, Carcinoma, Squamous Cell pathology, Image Cytometry methods, Mouth Neoplasms pathology, Precancerous Conditions pathology
- Abstract
Purpose: Detection of a precancerous or cancerous lesion when small is one of the most important factors to improve 5-year survival rates of oral cancer. Although surgical biopsy is the most definitive method for diagnosing oral lesions, it is impractical to routinely subject large numbers of patients to biopsy. Recently, cytomorphometric assessments improved by advanced computer-assisted image analysis systems have gained importance. This study was established to evaluate the efficacy of nuclear cytomorphometric analysis and DNA ploidy status for the detection of oral malignancies. Methods used for cytomorphometric analysis were also reviewed., Patients and Methods: Oral mucosal smears (n = 44) were obtained from patients (n = 22) presenting with various oral lesions using a cytobrush immediately before biopsy. Cytomorphometric measurements and nuclear Feulgen DNA content analysis were carried out after the Feulgen staining procedure. Smears from the lesion site constituted the study group whereas contralateral healthy mucosal sites served as control., Results: DNA ploidy analysis revealed 20 diploid (90.9%) and 2 aneuploid DNA patterns (9.1%) sampled from the lateral margin of the tongue and floor of the mouth. When only malignant lesions were considered, aneuploidy rate was 16.7% whereas a diploid pattern was indicated for 83.3% of the sample. With cytomorphometric measurements, a statistically significant difference was shown for nuclear perimeter, area, diameter equivalent to circle, minimum and maximum Feret, intensity, DNA content (c) and DNA index values., Conclusions: Cytomorphometric analysis via oral brush biopsy is a valuable adjunct to biopsy for identification of premalignant and early stage cancerous oral lesions as a rapid and minimally invasive procedure with high specificity and sensitivity rates, requiring no topical or local anesthetic.
- Published
- 2006
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40. A histopathologic investigation on the effects of electrical stimulation on periodontal tissue regeneration in experimental bony defects in dogs.
- Author
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Kaynak D, Meffert R, Günhan M, and Günhan O
- Subjects
- Animals, Bone Resorption pathology, Dental Cementum pathology, Dogs, Epithelial Attachment pathology, Female, Inflammation, Male, Mandible, Osteoblasts pathology, Osteoclasts pathology, Periodontal Ligament pathology, Time Factors, Tooth Apex pathology, Tooth Cervix pathology, Alveolar Bone Loss therapy, Alveolar Process pathology, Bone Regeneration physiology, Electric Stimulation Therapy instrumentation, Electric Stimulation Therapy methods
- Abstract
Background: One endpoint of periodontal therapy is to regenerate the structure lost due to periodontal disease. In the periodontium, gingival epithelium is regenerated by oral epithelium. Underlying connective tissue, periodontal ligament, bone, and cementum are derived from connective tissue. Primitive connective tissue cells may develop into osteoblasts and cementoblasts, which form bone and cementum. Several procedural advances may support these regenerations; however, the regeneration of alveolar bone does not always occur. Therefore, bone stimulating factors are a main topic for periodontal reconstructive research. The present study was designed to examine histopathologically whether the application of an electrical field could demonstrate enhanced alveolar and cementum regeneration and modify tissue factors., Methods: Seven beagle dogs were used for this experiment. Mandibular left and right sides served as control and experimental sides, respectively, and 4-walled intrabony defects were created bilaterally between the third and fourth premolars. The experimental side was treated with a capacitively coupled electrical field (CCEF) (sinusoidal wave, 60 kHz, and 5 V peak-to-peak), applied for 14 hours per day. The following measurements were performed on the microphotographs: 1) the distance from the cemento-enamel junction to the apical notch (CEJ-AN) and from the crest of newly formed bone (alveolar ridge) to the apical notch (AR-AN); 2) the thickness of new cementum in the apical notch region; and 3) the length of junctional epithelium. The following histopathologic parameters were assessed by a semiquantitative subjective method: 1) inflammatory cell infiltration (ICI); 2) cellular activity of the periodontal ligament; 3) number and morphology of osteoclasts; 4) resorption lacunae; and 5) osteoblastic activity., Results: The results showed that the quantity of new bone fill and the mean value of the thickness of the cementum were significantly higher for the experimental side (P < 0.01). The location of the base of the pocket was positioned more coronally with respect to the apical point of the coronal notch in the experimental side (statistically significant P < 0.01). The length of the junctional epithelium and the number of osteoclasts were higher in the stimulated side than the coronal side; these findings were also statistically significant (P < 0.01). The comparison of the electrically stimulated versus non-stimulated mandibles with the semiquantitative subjective method demonstrated statistically significant differences in defined histopathologic parameters, except for osteoclast morphologies (P > 0.05)., Conclusions: This study demonstrated that the CCEF method has the potential to produce reconstructive effects and bone deposits. Further investigations with respect to the theoretical determination of local field parameters of the periodontal tissue complex, such as permittivity, conductivity, strength of the field electrical stimulation applied to the periodontal field current density, wavelength, and signal frequency appropriate for this field, should be undertaken. Using different electromotive forces alone or in combination with bone graft materials, guided tissue regeneration techniques, and dental implants may achieve a new dimension in periodontal therapy in the near future.
- Published
- 2005
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41. Chondrosarcoma of the parapharyngeal space. A case report.
- Author
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Simşek B, Köybaşioğlu A, Yücel E, and Günhan O
- Subjects
- Aged, Chondrosarcoma surgery, Female, Humans, Pharyngeal Neoplasms surgery, Chondrosarcoma pathology, Pharyngeal Neoplasms pathology
- Abstract
Chondrosarcomas are the malignant cartilagenous tumors and they are seen rarely in the head and neck area. They are usually slow growing lesions. The head and neck chondrosarcomas may show an aggressive course and the occurrence of this malignant cartilagenous tumor in the parapharyngeal space is only a few. They are mostly located in relation with jaw bones and base of the skull. Chondrosarcomas of the parapharyngeal space are limited in number and among them there is no low-grade one. In this case report, a case of low-grade chondrosarcoma which was treated with a simple excision without neck dissection was reported.
- Published
- 2005
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42. Botryoid odontogenic cyst: report of a case with extensive epithelial proliferation.
- Author
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Uçok O, Yaman Z, Günhan O, Uçok C, Doğan N, and Baykul T
- Subjects
- Adult, Cell Proliferation, Epithelial Cells pathology, Female, Humans, Mandibular Diseases pathology, Odontogenic Cysts pathology
- Abstract
Botyroid odontogenic cyst (BOC) is considered a rare multilocular variant of the lateral periodontal cyst. In this report; clinical and histopathological features of a case of BOC found in mandibular mental region of a 32-year-old woman is presented. There was a multilocular radiolucency extending from the roots of the right premolar to the left premolar, involving almost the whole height of the mandible. Histologically, there was extensive intraluminal epithelial proliferation in the lining and MIB-1 positive cells were noted in the basal layer.
- Published
- 2005
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43. MIB-1 expression in odontogenic epithelial rests, epithelium of healthy oral mucosa and epithelium of selected odontogenic cysts. An immunohistochemical study.
- Author
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Saraçoğlu U, Kurt B, Günhan O, and Güven O
- Subjects
- Cell Proliferation, Cells, Cultured, Dental Sac cytology, Humans, Immunoenzyme Techniques, Mouth Mucosa cytology, Tooth, Unerupted pathology, Tooth, Unerupted surgery, Dental Sac metabolism, Epithelial Cells metabolism, Ki-67 Antigen biosynthesis, Mouth Mucosa metabolism, Odontogenic Cysts metabolism, Tooth, Unerupted metabolism
- Abstract
The aim of this study is to investigate the proliferative potential of rests of odontogenic epithelium found in follicles of unerupted teeth, epithelium of oral mucosa and epithelial linings of various odontogenic cysts. MIB-1 expression was studied in the rests of odontogenic epithelium (n=10), healthy oral mucosa (n=10), odontogenic keratocysts (n=10) and other odontogenic cysts (n=10) using an avidin-biotin peroxidase technique on paraffin sections. The number of positively stained cells was counted on 10 representative areas of epithelium using a x40 objective. The average number of MIB-1 positive cells in each group was calculated. No MIB-1 positive cells were seen in the rests of odontogenic epithelium. The mean numbers of MIB-1 positive cells detected within the epithelium of oral mucosa, and of radicular and dentigerous cysts were similar. The number of MIB-1 positive cells was found to be increased in the presence of marked inflammatory cell infiltration. The highest number of MIB-1 positive cells was seen in the keratocysts. These findings suggest that removal of an unerupted tooth to prevent the possibility of neoplastic transformation of rests of odontogenic epithelium is not a justifiable rationale.
- Published
- 2005
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44. Contribution of morphometry in the differential diagnosis of fine-needle thyroid aspirates.
- Author
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Karslioğlu Y, Celasun B, and Günhan O
- Subjects
- Adenocarcinoma, Follicular diagnosis, Adenoma diagnosis, Analysis of Variance, Carcinoma diagnosis, Carcinoma, Papillary diagnosis, Cell Nucleus metabolism, Diagnosis, Differential, Goiter diagnosis, Humans, Image Processing, Computer-Assisted, Multivariate Analysis, Sensitivity and Specificity, Software, Statistics as Topic methods, Thyroid Diseases diagnosis, Biopsy, Fine-Needle methods, Cell Biology, Thyroid Gland pathology, Thyroid Neoplasms diagnosis
- Abstract
Background: Cytologic discrimination of cellular nodules, follicular adenoma, and follicular carcinoma in the thyroid is problematic. Methods are needed to achieve a reliable diagnosis. Some sophisticated tools, such as microarrays, offer great potential but lack accompanying morphologic information., Methods: One hundred twelve samples obtained from patients with lesions histopathologically diagnosed as nodular goiter, follicular adenoma, follicular carcinoma, and papillary carcinoma were used. Eight geometric features, such as nuclear area and circular form factor, were measured. The dataset was divided into six overlapping groups to represent the frequently encountered situations in routine practice. Multivariate analysis of variance, Tukey's honestly significant differences test, and discriminant analysis were performed. Statistical analysis was carried out with two conceptually different approaches. In the first, data from all measured nuclei were used. In the second, a subset of data representing the most extreme values of variables was extracted from the entire dataset to simulate the "selection procedure" performed during conventional morphologic examination., Results: When the selected dataset instead of data from all measured nuclei was used, the correct classification rates in discriminant analysis improved considerably., Conclusions: Morphologic examination is based primarily on selection. Using data obtained from all of the cells in morphometry may cause a dilution effect in diagnostically important features. Morphometric studies may also be planned with a proper selection "bias." This may be particularly helpful when isolated abnormal cells carry most of the diagnostic information., (Copyright 2005 Wiley-Liss, Inc.)
- Published
- 2005
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45. Periodontal regenerative potential of autogenous periodontal ligament grafts in Class II furcation defects.
- Author
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Akbay A, Baran C, Günhan O, Ozmeriç N, and Baloş K
- Subjects
- Adult, Analysis of Variance, Cell Transplantation, Female, Humans, Male, Mandible, Middle Aged, Molar surgery, Periodontal Ligament cytology, Surgical Flaps, Furcation Defects surgery, Oral Surgical Procedures methods, Periodontal Ligament transplantation, Regeneration
- Abstract
Background: The aim of the present study was to evaluate the regenerative potential of autogenous periodontal ligament (PDL) grafts in the treatment of Class II furcation defects., Methods: Twenty mandibular Class II furcation defects from 10 systemically healthy patients with chronic periodontitis were selected. In experimental defects, flaps were coronally positioned following placing autogenous PDL grafts that were obtained from third molars; in controls, coronally advanced flap procedure without graft was applied. Clinical measurements including plaque index, gingival index, probing depth (PD), vertical and horizontal clinical attachment level (CAL), and gingival recession (GR) were obtained at baseline and after 3 and 6 months postoperatively. Vertical and horizontal defect fill was evaluated with open clinical measurements at initial surgery and reentry after 6 months. Gingival biopsies from the experimental and control defects were obtained at reentry and evaluated histopathologically in order to examine the soft tissue response towards PDL grafts., Results: Sites treated with PDL grafts demonstrated significant improvement in vertical and horizontal defect fill, PD, and CAL at 3 and 6 months compared to presurgical values. The difference determined for the PD values of both groups at a statistically significant degree in favor of grafted sites was maintained at all observation periods. No foreign body reaction was observed in PDL grafts., Conclusions: These short-term results point to the potential of PDL grafts in promoting healing of furcation lesions. This preliminary study suggests that the use of PDL grafts may have beneficial effects in the treatment of furcation defects.
- Published
- 2005
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46. Fibrolipomatous hamartoma in a patient with tuberous sclerosis: report of a case.
- Author
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Celenk P, Alkan A, Canger EM, and Günhan O
- Subjects
- Adipocytes pathology, Adolescent, Calcinosis pathology, Collagen, Curettage, Hamartoma pathology, Humans, Male, Mandibular Diseases pathology, Tomography, X-Ray Computed, Hamartoma complications, Mandibular Diseases complications, Tuberous Sclerosis complications
- Abstract
Tuberous sclerosis is a rare congenital disorder with an incidence of 1 in 6000 births. The classic triad is seizure, mental deficiency, and angiofibromas. Orofacial manifestations include fibrous hyperplasia, hemangioma, bifid uvula, cleft lip and palate, macroglossia, high arched palate, and enamel defects. Benign tumors of the jaws including desmoplastic fibroma, calcifying odontogenic tumor, and odontogenic myxoma have been recently reported in tuberous sclerosis. This case report adds fibrolipomatous hamartoma of the mandible to this list.
- Published
- 2005
- Full Text
- View/download PDF
47. Role of fine needle aspiration cytology in the preoperative presumptive diagnosis of ameloblastoma.
- Author
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Uçok O, Doğan N, Uçok C, and Günhan O
- Subjects
- Adult, Ameloblastoma pathology, Biopsy, Fine-Needle, Diagnosis, Differential, Female, Follow-Up Studies, Humans, Male, Mandibular Neoplasms pathology, Mandibular Neoplasms surgery, Maxillary Neoplasms pathology, Maxillary Neoplasms surgery, Neoplasm Recurrence, Local, Retrospective Studies, Ameloblastoma diagnosis, Mandibular Neoplasms diagnosis, Maxillary Neoplasms diagnosis
- Abstract
Objective: To determine the role of fine needle aspiration cytology (FNAC) on the preoperative presumptive diagnosis of ameloblastoma., Study Design: Sixty-three patients, diagnosed preoperatively and postoperatively with ameloblastoma, were evaluated between 1990 and 2003. The patients were classified according to whether they were diagnosed with ameloblastoma preoperatively or postoperatively, on histologic examination., Results: The accuracy rate for ameloblastoma was 0.95% for all biopsy methods, while the incisional biopsy rate was 75.00%. Concerning clinical diagnosis, ameloblastoma was mistaken mostly (56.41%) for odontogenic cysts (22 of 39)., Conclusion: FNAC should be utilized more commonly on intraosseous and soft tissue lesions in the oral and maxillofacial regions, to obtain sufficient material. It is convenient, inexpensive and noninvasive as compared with other biopsy methods.
- Published
- 2005
- Full Text
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48. Persistent painful swelling in the posterior mandible.
- Author
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Oz G, Dolanmaz D, Uçkan S, Günhan O, and Armstrong JW
- Subjects
- Adult, Diagnosis, Differential, Female, Fibrosis, Follow-Up Studies, Hemorrhage pathology, Humans, Radiography, Panoramic, Tomography, X-Ray Computed, Bone Cysts, Aneurysmal pathology, Mandibular Diseases pathology
- Published
- 2004
- Full Text
- View/download PDF
49. Comparison of C-erbB2 (HER-2/Neu) immunohistochemistry results on invasive breast carcinomas. Experience of 2 Pathology departments in Turkey and Greece.
- Author
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Günhan O, Kafousi M, Kurt B, Koutsopoulos AV, Karslioğlu Y, Stathopoulos E, and Celasun B
- Subjects
- Greece, Humans, Immunohistochemistry, Neoplasm Invasiveness, Reproducibility of Results, Turkey, Breast Neoplasms metabolism, Breast Neoplasms pathology, Pathology standards, Receptor, ErbB-2 analysis
- Abstract
Objective: To compare c-erbB2 (HER-2/Neu) immunohistochemical staining results obtained in 2 pathology departments and evaluate the reproducibility of staining and assessments., Study Design: Ninety primary invasive ductal carcinoma cases constituted the material of this study. For concordant assessment, serial sections from the same tissue blocks were prepared in both Turkey and Greece and were sent to each other. Evaluation of c-erbB2 (HER-2/Neu) staining was done independently in 2 departments by experienced pathologists. Stained slides were evaluated semiquantitatively in Turkey and both semiquantitatively and automatically in Greece., Results: There was complete agreement on staining density in 58 (64.4%) cases in both centers. In 15 cases there were major discordances in staining degrees, and in 17 cases there was a major discordance. Hypothetical treatment decisions based on these results showed that 82% of patients would have been handled the same way., Conclusion: Comparison of immunostaining patterns performed at 2 centers provided valuable data that may be used in the development of quality assurance policies. The present study showed the usefulness of multicenter comparative studies in initiating the development of guidelines.
- Published
- 2004
50. Morphological and immunohistochemical changes on rat skin exposed to nitrogen mustard.
- Author
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Günhan O, Kurt B, Karayilanoğlu T, Kenar L, and Celasun B
- Subjects
- Animals, Burns, Chemical pathology, Erythema chemically induced, Erythema pathology, Immunohistochemistry, Neutrophils drug effects, Neutrophils pathology, Rats, Burns, Chemical etiology, Chemical Warfare Agents toxicity, Mustard Gas toxicity, Skin drug effects, Skin pathology
- Abstract
Objective: The aim of this study was to understand the mechanism of nitrogen mustard on skin., Methods: Nitrogen mustard was applied on ventral skin of 30 rats. Sequential biopsies were taken during the postexposure period. Slides were stained with hematoxylin-eosin and keratin PAN and high molecular weight cytokeratin and keratin 5., Results: The earliest findings are minimal polymorphonuclear leukocytes extravasation and edema. Heavy inflammation with formation of vesicles and bulla were present at 24 hours. At 6 hours, the upper epidermal cells showed weak staining with high molecular weight cytokeratin and keratin PAN. At 24 and 48 hours, only patchy areas of staining with high molecular weight cytokeratin and keratin 5 were present., Conclusion: One of the major mechanisms of injury by nitrogen mustard may be the disruption of cytoskeletal filament network.
- Published
- 2004
- Full Text
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