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Treatment of localized Langerhans' cell histiocytosis of the mandible with intralesional steroid injection: report of a case.
- Source :
-
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics [Oral Surg Oral Med Oral Pathol Oral Radiol Endod] 2010 Feb; Vol. 109 (2), pp. e53-8. - Publication Year :
- 2010
-
Abstract
- Localized Langerhans cell histiocytosis (LLCH), formerly known as eosinophilic granuloma, mainly affects the skull, mandible, vertebrae, and ribs in children and the long bones of adults. Symptoms range from none to pain, swelling, and tenderness over the site of the lesion. General malaise and fever occasionally are present. Radiographically, lesions appear as radiolucent areas with well demarcated borders. LLCH may resolve spontaneously after biopsy in a period of months to years. However, if features include continuous pain, decrease of function, pathologic fractures, migration and resorption of teeth, or rapid progression, then active treatment needs to be considered. Treatment approaches include surgery, radiotherapy, chemotherapy, and intralesional injection of corticosteroids. In children with mandibular LLCH, 1 dose of methyprednisolone succinate injection has proven to be adequate. However, injections have not been performed in cases involving pathologic fracture. We report a new case of LLCH of the mandible that caused a pathologic fracture in an adult patient. Repeated intralesional corticosteroid injections resulted in fracture line disappearance within 14 months and lesion healing by the end of the 36-month follow-up.<br /> (Copyright (c) 2010 Mosby, Inc. All rights reserved.)
- Subjects :
- Adult
Fractures, Spontaneous diagnostic imaging
Histiocytosis, Langerhans-Cell diagnostic imaging
Histiocytosis, Langerhans-Cell pathology
Humans
Injections, Intralesional
Male
Mandibular Diseases diagnostic imaging
Mandibular Diseases pathology
Mandibular Fractures diagnostic imaging
Radiography, Panoramic
Fractures, Spontaneous drug therapy
Glucocorticoids administration & dosage
Histiocytosis, Langerhans-Cell drug therapy
Mandibular Diseases drug therapy
Mandibular Fractures drug therapy
Methylprednisolone Hemisuccinate administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1528-395X
- Volume :
- 109
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
- Publication Type :
- Academic Journal
- Accession number :
- 20123398
- Full Text :
- https://doi.org/10.1016/j.tripleo.2009.10.015