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1. Exploring the association between physical activity and gut microbiota composition: a review of current evidence

Author

Gallè, F., Valeriani, F., Cattaruzza, M. S., Ubaldi, F., Romano Spica, V., Liguori, G., GSMS-SItI, Calimeri, S., Bono, R., Privitera, G., Fabiani, L., D’Aloisio, F., Baccari, G., Leoni, E., Tafuri, S., Brandi, G., Gervasi, G., Dell’Eva, A., Gradilone, A., Frangella, C., La Torre, A., Galle F., Valeriani F., Cattaruzza M.S., Ubaldi F., Romano Spica V., Liguori G., Baccari G., Bono R., Calimeri S., D'Aloisio F, Dell'Eva A., Fabiani L., Frangella C., Gerais G., Gradilone A., La Torre A., Leoni E., Privitera G., and Tafuri S.

Subjects
Bacteroidetes, Health, Animals, Firmicutes, Humans, Gut Microbiota, Health, Physical Activity, Exercise, Physical Activity, Gut Microbiota, digestive system, Exercise, Diet, Gastrointestinal Microbiome
Abstract

The gut microbiota is implicated in digestive, metabolic and immune processes of the host. The physiological and pathophysiological functions of the intestinal microbiota depend of its composition, and several individual or external factors may be associated with the presence of some categories, phyla or species of microorganisms in the gut. In particular, two bacterial phyla - Firmicutes and Bacteroidetes - are predominant in the human gut and their relative concentrations seem to be related with age, gender, diet habits and weight status. In the last decade, several studies have tried to characterize the possible role of physical activity in determining qualitative and quantitative composition of the intestinal microbiota. This review is aimed at exploring the current evidences regarding the association between physical activity and gut microbiota composition in animal models and in the humans. Further studies are needed to clarify the mutual relationships among exercise, diet, nutritional supplements/doping agents and gut microbiota.

Published
2019

2. Higher education on physical activity and sport: The Movement Sciences graduate as a resource to promote healthy lifestyles in the National Health System

Author

Liguori, G., Gallé, F., Di Onofrio, V., Valeriani, F., Romano Spica, V., Wdpp, GSMS-SItI, Trenti, T., Pasquarella, C., Fallace, P., Calimeri, S., Bono, R., Privitera, G., Fabiani, L., D’Aloisio, F., Baccari, G., Leoni, E., Tafuri, S., Brandi, G., Gervasi, G., Dell’Eva, A., Gradilone, A., Frangella, C., A. La Torre., Liguori G., Galle F., Di Onofrio V., Valeriani F., Romano Spica V., Baccari G., Bono R., Calimeri S., D'Aloisio F, Dell'Eva A., Fabiani L., Frangella C., Gerais G., Gradilone A., La Torre A., Leoni E., Privitera G., and Tafuri S.

Subjects
Movement Sciences, Health Promotion, Physical Activity, State Medicine, Professional Competence, Italy, Education, Professional, Quality of Life, Humans, Physical Activity, Movement Sciences, Health Promotion, Curriculum, Healthy Lifestyle, Movement Science, Cooperative Behavior, Exercise, Health Education, Sports
Abstract

Currently, physical activity is an important tool that may be useful to improve people health and quality of life through sustainable and effective interventions. In order to obtain durable improvements of individuals' behaviors, however, consistent changes in services organization and the creation of new opportunities in life settings are needed. This requires necessarily the involvement of complementary figures with specific competences. Considering their peculiar training curriculum, Movement Sciences graduates represent key figures in this context and they can operate fully in interventions of health education and promotion, within multidisciplinary teams collaborating with the National Health System (NHS), in order to obtain the global undertaking of citizens.

Published
2019

3. Mediterranean diet as a natural supplemental resource for athletes and physical activity

Author

Alonzo, E., Fardella, M., Cannizzaro, V., Faraoni, F., La Carrubba, R., Trille, S., Leonardi, F., WFG-SItI, Working Group Food Hygiene, Italian Society of Hygiene, Alonzo, Preventive Medicine and Public Health: E., Arras, P., Belotti, D., Bonaccorsi, G., Bonura, A. G., Cairella, G., Carreri, V., Chioffi, L., Cosentino, S., De Castelli, L., Di Giusto, M., De Giusti, M., Del Pio, T., Delia, S. A., Fabiani, R., Giostra, G., Grosso, G., Guberti, E., Laganà, P., Macchioni, D., Nucci, D., Panunzio, M., Perdelli, F., Pontieri, V., Schiavano, G., Sciarrone, R., Tamburro, M., Troiano, G., Ugolini, G., Villarini, M., Vino, F., Wdpp, Romano Spica, Working Group Doping Prevention: V., Savino, G., Trenti, T., Pasquarella, C., Liguori, G., Fallace, P., GSMS-SItI, Working Group on Movement Sciences for Health, Baccari, Italian Society of Hygiene Preventive Medicine and Public Health: G., Brandi, G., Bono, R., Calimeri, S., D’Aloisio, F., Dell’Eva, A., Fabiani, L., Frangella, C., Gervasi, G., Gradilone, A., La Torre, A., Leoni, E., Privitera, G., Tafuri, S., Alonzo E., Fardella M., Cannizzaro V., Faraoni F., La Carrubba R., Trille S.S., Leonardi F., Baccari G., Bono R., Calimeri S., D'Aloisio F, Dell'Eva A., Fabiani L., Frangella C., Gerais G., Gradilone A., La Torre A., Leoni E., Liguori G., Privitera G., and Tafuri S.

Subjects
Doping in Sports, Books, Doping prevention, Health literacy, Food education, Mediterranean diet, Sport, Mediterranean, Diet, Mediterranean, Peer Group, Diet, Italy, Athletes, Dietary Supplements, Humans, Cookbooks as Topic, Exercise, Health Education, human activities, Mediterranean diet, Sport, Doping prevention, Food education, Health literacy
Abstract

The WHO Global Action Plan on physical activity underlines the binomial "diet and physical activity" for the maintenance of well-being state. The adequate nutritional intake is required for sport and can be achieved by a well-adjusted diet without adding artificial food supplements, whose abuse can even represent a risk and appear as an antechamber of doping. Within a national doping prevention project, a peer education tool was realized in the form of a book and e-book, based on the principle of the Mediterranean Diet as an effective nutritional support in sport and physical activity. This health-literacy book contains recipes from all Italian regions revised for their capability to satisfy sport nutritional needs.

Published
2019

4. The prevention of doping and the improper use of drugs and food supplements in sports and physical activities: A survey on the activity of the prevention departments of Italian local health authorities

Author

Pasquarella C., Pompili M., Valeriani F., Morgado M., Milicia G. M., Veronesi L., Odone A., Zoni R., Saccani E., Savino G., Persi Y., Pinelli M., Liguori G., Galle F., Di Onofrio V., Fallace P., Romano Spica V., Calimeri S., Bono R., Privitera G., Fabiani L., D'Aloisio F., Baccari G., Leoni E., Tafuri S., Brandi G., Gervasi G., Dell'Eva A., Gradilone A., Frangella C., La Torre A., Trenti T., Agostini D., Aini M. A., Alonzo E., Assisi E., Belotti D., Cagnin R., Coppola L., Giorgino A., Libardi L., Manfredi Selvaggi T. M., Morgantini F., Parodi G., Pompei D., Santini I., Sticchi C., Ursino S., Pasquarella, C., Pompili, M., Valeriani, F., Morgado, M., Milicia, G. M., Veronesi, L., Odone, A., Zoni, R., Saccani, E., Savino, G., Persi, Y., Pinelli, M., Liguori, G., Galle, F., Di Onofrio, V., Fallace, P., Romano Spica, V., Calimeri, S., Bono, R., Privitera, G., Fabiani, L., D'Aloisio, F., Baccari, G., Leoni, E., Tafuri, S., Brandi, G., Gervasi, G., Dell'Eva, A., Gradilone, A., Frangella, C., La Torre, A., Trenti, T., Agostini, D., Aini, M. A., Alonzo, E., Assisi, E., Belotti, D., Cagnin, R., Coppola, L., Giorgino, A., Libardi, L., Manfredi Selvaggi, T. M., Morgantini, F., Parodi, G., Pompei, D., Santini, I., Sticchi, C., and Ursino, S.

Subjects
Doping in Sports, Prevention, Drugs, Health Promotion, State Medicine, Prevention departments, Italy, Athletes, Food supplements, Surveys and Questionnaires, Dietary Supplements, Doping, Humans, Public Health
Abstract

Introduction. Doping is an important public health problem widespread not only among elite athletes, but also among amateur and recreational athletes and the general population. In Italy the introduction of doping prevention within the Essential Levels of Care (LEA) with the DPCM 12/1/2017 represents a crucial step towards the implementation of education and health promotion interventions. In this context, the Departments of Prevention (DP) of the Local Health Authorities (LHA) have to play a fundamental role, becoming the cultural and operational reference on this issue. As part of the "Doping prevention: development of a permanent educational tool coordinated by the National Health Service Prevention Departments" project, funded by the Italian Ministry of Health, a survey was conducted on the activities carried out by the DP regarding doping prevention and improper use and abuse of drugs and food supplements in sports and physical activities, as a basis for the harmonization of organizational structures and prevention programs and the creation of a collaboration network at a regional and national level. Methods. A semi-structured questionnaire consisting of 11 questions, prepared on an electronic platform, was sent to the DP of all the Italian LHA. Results. A total of 38 DP out of 131 (29%) completed the questionnaire, with representation from all regions. 42.1% of DP carried out or are still running programs for the prevention of doping, a percentage that decreases to 27% considering the programs for the prevention of misuse and abuse of drugs and food supplements in sports and in physical activities; in less than half of the DP, 37.5% and 41.7%, respectively, dedicated funds have been allocated. The professionals most involved in prevention of doping are the Specialists in Sport Medicine (81.3%) followed by Specialists in Hygiene (43.8%) and Psychologists (37.5%), while Health Care Assistants (50%) are the professionals most involved in the prevention of the improper use of drugs and food supplements, followed by Specialists in Hygiene and Specialists in Sport Medicine (40%). Most of the DP (71.9%) believe that the introduction of programs to prevent and counteract doping in the LEA will have repercussions on their approach against doping. Conclusions. The survey, although conducted on a limited sample, has provided an important framework relating to programs for the prevention of doping and the misuse and abuse of drugs and food supplements in sports and in the physical activities carried out by DP. A remarkable heterogeneity has been highlighted, both at national and regional level. It is urgent to provide DP with homogeneous and effective organizational models and adequate operational tools, paying particular attention to the training of all the professionals involved. It is also essential to implement permanent monitoring tools.

Published
2019

5. Adapted Physical Activity for the Promotion of Health and the Prevention of Multifactorial Chronic Diseases: the Erice Charter

Author

Spica V. R., Macini P., Galeone D., Liguori G., Signorelli C., Marensi L., Vagali P., Guberti E., Goletti M., Mammina C., Tabacchi G., Izzotti A., Cinquetti S., Pellizzari B., Beltrami P., Alonzo E., Gradilone A., Leoni E., Buono P., Brandi G., Di Rosa E., Parisi A., Capolongo S., Fantuzzi G., Aggazzotti G., Grillo C., Borella P., Manzoli L., Fabiani L., Faggiano F., Mete R., Privitera G., Coniglio M. A., Frangella C., Rossi D., Lagorio S., Pasquarella M. L., Isabella A., Tripi F., Franceschetti R., Commare A. L., Galle F., Brandimarte M. A., Savino G., Di Onofrio V., Tortorella F., Gabriele M., Monreale V., Abrignani M., Ferreri G., Cacciapuoti A., Valeriani F., Raffo M., Matarese M., Ripani M., Altana V., Antonioni S., Anzalone C., Astorino G., Azzollini A., Belfiore P., Valentini F. B., Bragazzi N. L., Calaciura A., Casano D., Ciulla A., Cono O. E., Contrisciani R., Cosenza B., D'Aloisio F., Antonino D. F., Marchis A. D., Francesco D. N., Fabri S., Famiglietti E., Gandolfi A., Genovese C., Genovesi A., Gianfredi V., Gigante S., Gigliotti A., Iacona C., Innocenzi L., Laurita V., Maratea F., Meletti L., Memmini S., Messana M. A., Morelli C., Nappi M. R., Nucci D., Orlandi P., Palamara M. A. R., Patti A., Persi Y., Polisano B., Roccaro D., Ricchiuti R., Sanclemente L., Scanavini S., Sirtori M. D., Soncini F., Stelitano G. I., Valenzano A. A., Veicsteinas A., Fara G. M., Giammanco G., Romano-Spica V., Spica V.R., Macini P., Galeone D., Liguori G., Signorelli C., Marensi L., Vagali P., Guberti E., Goletti M., Mammina C., Tabacchi G., Izzotti A., Cinquetti S., Pellizzari B., Beltrami P., Alonzo E., Gradilone A., Leoni E., Buono P., Brandi G., Di Rosa E., Parisi A., Capolongo S., Fantuzzi G., Aggazzotti G., Grillo C., Borella P., Manzoli L., Fabiani L., Faggiano F., Mete R., Privitera G., Coniglio M.A., Frangella C., Rossi D., Lagorio S., Pasquarella M.L., Isabella A., Tripi F., Franceschetti R., Commare A.L., Galle F., Brandimarte M.A., Savino G., Di Onofrio V., Tortorella F., Gabriele M., Monreale V., Abrignani M., Ferreri G., Cacciapuoti A., Valeriani F., Raffo M., Matarese M., Ripani M., Altana V., Antonioni S., Anzalone C., Astorino G., Azzollini A., Belfiore P., Valentini F.B., Bragazzi N.L., Calaciura A., Casano D., Ciulla A., Cono O.E., Contrisciani R., Cosenza B., D'Aloisio F., Antonino D.F., Marchis A.D., Francesco D.N., Fabri S., Famiglietti E., Gandolfi A., Genovese C., Genovesi A., Gianfredi V., Gigante S., Gigliotti A., Iacona C., Innocenzi L., Laurita V., Maratea F., Meletti L., Memmini S., Messana M.A., Morelli C., Nappi M.R., Nucci D., Orlandi P., Palamara M.A.R., Patti A., Persi Y., Polisano B., Roccaro D., Ricchiuti R., Sanclemente L., Scanavini S., Sirtori M.D., Soncini F., Stelitano G.I., Valenzano A.A., Veicsteinas A., Fara G.M., Giammanco G., and Romano-Spica V.

Subjects
Biomedical Research, Prevention parole chiave, Adapted physical activity, Health Promotion, Motor Activity, Health promotion, Prevention, Primary Prevention, Attività fisica adattata, Prevenzione, Italy, Physician, Promozione della salute, Chronic Disease, Public Health, Human, Specialization
Abstract

The Erice Charter was unanimously approved at the conclusion of the 47th Residential Course "Adapted Physical Activity in Sport, Wellness and Fitness: New Challenges for Prevention and Health Promotion", held on 20-24 April 2015 in Erice, Italy, at the "Ettore Majorana" Foundation and Centre for Scientific Culture, and promoted by the International School of Epidemiology and Preventive Medicine "G. D'Alessandro" and the Study Group on Movement Sciences for Health of the Italian Society of Hygiene, Preventive Medicine and Public Health. After an intense discussion the participants identified the main points associated with the relevance of physical activity for Public Health, claiming the pivotal role of the Department of Prevention in coordinating and managing preventive actions. The participants underlined the importance of the physicians specialized in Hygiene, Preventive Medicine and Public Health. The contribution of other operators such as physicians specialized in Sport Medicine was stressed. Further, the holders of the new degree in Human Movement and Sport Sciences were considered fundamental contributors for the performance of physical activity and their presence was seen as a promising opportunity for the Departments of Prevention. Primary prevention based on recreational physical activities should become easily accessible for the population, avoiding obstacles such as certification steps or complex bureaucracy. The Sport Doctor is recognized as the principal referent for preliminary physical evaluation and clinical monitoring in secondary and tertiary prevention actions based on adapted physical activities. Developing research in the field is essential as well as implementing higher education on physical activity management in Schools of Public Health.

Published
2015

6. Adapted physical activity for the promotion of health and the prevention of multifactorial chronic diseases: The Erice Charter

Author

Spica, V. R., Macini, P., Galeone, D., Liguori, G., Signorelli, C., Marensi, L., Vagali, P., Guberti, E., Goletti, M., Mammina, C., Tabacchi, G., Izzotti, A., Cinquetti, S., Pellizzari, B., Beltrami, P., Alonzo, E., Gradilone, A., Leoni, E., Buono, P., Brandi, G., Di Rosa, E., Parisi, A., Capolongo, S., Fantuzzi, G., Aggazzotti, G., Grillo, C., Borella, P., Manzoli, L., Fabiani, L., Faggiano, F., Mete, R., Privitera, G., Coniglio, M. A., Frangella, C., Rossi, D., Lagorio, S., Pasquarella, M. L., Isabella, A., Tripi, F., Franceschetti, R., Commare, A. L., Galle, F., Brandimarte, M. A., Savino, G., Di Onofrio, V., Tortorella, F., Gabriele, M., Monreale, V., Abrignani, M., Ferreri, G., Cacciapuoti, A., Valeriani, F., Raffo, M., Matarese, M., Ripani, M., Altana, V., Antonioni, S., Anzalone, C., Astorino, G., Azzollini, A., Belfiore, P., Valentini, F. B., Bragazzi, N. L., Calaciura, A., Casano, D., Ciulla, A., Cono, O. E., Contrisciani, R., Cosenza, B., D'Aloisio, F., Antonino, D. F., Marchis, A. D., Francesco, D. N., Fabri, S., Famiglietti, E., Gandolfi, A., Genovese, C., Genovesi, A., Gianfredi, V., Gigante, S., Gigliotti, A., Iacona, C., Innocenzi, L., Laurita, V., Maratea, F., Meletti, L., Memmini, S., Messana, M. A., Morelli, C., Nappi, M. R., Nucci, D., Orlandi, P., Palamara, M. A. R., Patti, A., Persi, Y., Polisano, B., Roccaro, D., Ricchiuti, R., Sanclemente, L., Scanavini, S., Sirtori, M. D., Soncini, F., Stelitano, G. I., Valenzano, A. A., Veicsteinas, A., Fara, G. M., Giammanco, G., and Romano-Spica, V.

Subjects
Biomedical Research, Prevention, Adapted physical activity, Health Promotion, Motor Activity, Primary Prevention, Attività fisica adattata, Italy, Physicians, Chronic Disease, Humans, Public Health, Adapted physical activity, Attività fisica adattata, Health promotion, Prevention, Biomedical Research, Chronic Disease, Health Promotion, Humans, Italy, Motor Activity, Physicians, Primary Prevention, Specialization, Public Health, Specialization
Published
2015

9. Adapted Physical Activity for the Promotion of Health and the Prevention of Multifactorial Chronic Diseases: the Erice Charter

Author

Spica, Vincenzo Romano, Macini, Pierluigi, Galeone, Daniela, Liguori, Giorgio, Signorelli, Carlo, Marensi, Lorenzo, Vagali, Pierluigi, Guberti, Emilia, Goletti, Mauro, Mammina, Caterina, Tabacchi, Garden, Izzotti, Alberto, Cinquetti, Sandro, Pellizzari, Barbara, Beltrami, Patrizia, Alonzo, Elena, Gradilone, Antonio, Leoni, Erica, Buono, Pasqualina, Brandi, Giorgio, Rosa, Enrico Di, Parisi, Attilio, Capolongo, Stefano, Fantuzzi, Guglielmina, Aggazzotti, Gabriella, Grillo, Claudio, Borella, Paola, Manzoli, Lamberto, Fabiani, Leila, Faggiano, Fabrizio, Mete, Rosario, Privitera, GAETANO PIERPAOLO, Coniglio, Maria Anna, Frangella, Claudia, Rossi, Daniela, Lagorio, Silvia, Pasquarella, Maria Luisa, Isabella, Albino, Tripi, Ferdinando, Franceschetti, Romano, Commare, Antonella La, Gallè, Francesca, Brandimarte, Maria Alessandra, Savino, Gustavo, Onofrio, Valeria Di, Tortorella, Franco, Gabriele, Michele, Monreale, Vincenzo, Abrignani, Maurizio, Ferreri, Giovanni, Cacciapuoti, Antonio, Valeriani, Federica, Raffo, Marisa, Matarese, Massimo, Ripani, Maurizio, Altana, Valentina, Antonioni, Stefania, Anzalone, Concetta, Astorino, Gerardo, Azzollini, Annunziata, Belfiore, Patrizia, Valentini, Fabio Besozzi, Bragazzi, Nicola Luigi, Calaciura, Antonella, Casano, Diego, Ciulla, Antonio, Cono, Osvaldo Ernandez, Contrisciani, Roberta, Cosenza, Bruno, D’Aloisio, Francesco, Antonino, De Francesco, Marchis, Antonella De, Francesco, Di Nardo, Fabri, Serena, Famiglietti, Elena, Gandolfi, Angela, Genovese, Cristina, Genovesi, Antonio, Gianfredi, Vincenza, Gigante, Sebastiano, Gigliotti, Alfredina, Iacona, Claudia, Innocenzi, Ludovico, Laurita, Vincenzo, Maratea, Fabio, Meletti, Luca, Memmini, Silvia, Messana, Maria Anna, Morelli, Cristina, Nappi, Maria Rosaria, Nucci, Daniele, Orlandi, Pierluigi, Palamara, Maria Angela Rita, Patti, Anna, Persi, Ylenia, Polisano, Benedetta, Roccaro, Davide, Ricchiuti, Roberta, Sanclemente, Leonardo, Scanavini, Sara, Sirtori, Mario Donato, Soncini, Francesco, Stelitano, Gilda Immacolata, Valenzano, Anna Antonia, Veicsteinas, Arsenio, Fara, Gaetano Maria, Giammanco, Giuseppe, Spica, V. R., Macini, P., Galeone, D., Liguori, G., Signorelli, C., Marensi, L., Vagali, P., Guberti, E., Goletti, M., Mammina, C., Tabacchi, G., Izzotti, A., Cinquetti, S., Pellizzari, B., Beltrami, P., Alonzo, E., Gradilone, A., Leoni, E., Buono, P., Brandi, G., Di Rosa, E., Parisi, A., Capolongo, S., Fantuzzi, G., Aggazzotti, G., Grillo, C., Borella, P., Manzoli, L., Fabiani, L., Faggiano, F., Mete, R., Privitera, G., Coniglio, M. A., Frangella, C., Rossi, D., Lagorio, S., Pasquarella, M. L., Isabella, A., Tripi, F., Franceschetti, R., Commare, A. L., Galle, F., Brandimarte, M. A., Savino, G., Di Onofrio, V., Tortorella, F., Gabriele, M., Monreale, V., Abrignani, M., Ferreri, G., Cacciapuoti, A., Valeriani, F., Raffo, M., Matarese, M., Ripani, M., Altana, V., Antonioni, S., Anzalone, C., Astorino, G., Azzollini, A., Belfiore, P., Valentini, F. B., Bragazzi, N. L., Calaciura, A., Casano, D., Ciulla, A., Cono, O. E., Contrisciani, R., Cosenza, B., D'Aloisio, F., Antonino, D. F., Marchis, A. D., Francesco, D. N., Fabri, S., Famiglietti, E., Gandolfi, A., Genovese, C., Genovesi, A., Gianfredi, V., Gigante, S., Gigliotti, A., Iacona, C., Innocenzi, L., Laurita, V., Maratea, F., Meletti, L., Memmini, S., Messana, M. A., Morelli, C., Nappi, M. R., Nucci, D., Orlandi, P., Palamara, M. A. R., Patti, A., Persi, Y., Polisano, B., Roccaro, D., Ricchiuti, R., Sanclemente, L., Scanavini, S., Sirtori, M. D., Soncini, F., Stelitano, G. I., Valenzano, A. A., Veicsteinas, A., Fara, G. M., and Giammanco, G.

Subjects
Biomedical Research, Adapted physical activity, Health promotion, Prevention, Chronic Disease, Health Promotion, Humans, Italy, Motor Activity, Physicians, Primary Prevention, Specialization, Public Health, Prevention parole chiave, Physical Activity, Health Promotion, Prevention, Chronic Diseases, Erice Charter, Physical Activity, Erice Charter, Attività fisica adattata, Prevenzione, Promozione della salute, Chronic Diseases, health promotion, prevention
Abstract

The Erice Charter was unanimously approved at the conclusion of the 47th Residential Course "Adapted Physical Activity in Sport, Wellness and Fitness: New Challenges for Prevention and Health Promotion", held on 20-24 April 2015 in Erice, Italy, at the "Ettore Majorana" Foundation and Centre for Scientific Culture, and promoted by the International School of Epidemiology and Preventive Medicine "G. D'Alessandro" and the Study Group on Movement Sciences for Health of the Italian Society of Hygiene, Preventive Medicine and Public Health. After an intense discussion the participants identified the main points associated with the relevance of physical activity for Public Health, claiming the pivotal role of the Department of Prevention in coordinating and managing preventive actions. The participants underlined the importance of the physicians specialized in Hygiene, Preventive Medicine and Public Health. The contribution of other operators such as physicians specialized in Sport Medicine was stressed. Further, the holders of the new degree in Human Movement and Sport Sciences were considered fundamental contributors for the performance of physical activity and their presence was seen as a promising opportunity for the Departments of Prevention. Primary prevention based on recreational physical activities should become easily accessible for the population, avoiding obstacles such as certification steps or complex bureaucracy. The Sport Doctor is recognized as the principal referent for preliminary physical evaluation and clinical monitoring in secondary and tertiary prevention actions based on adapted physical activities. Developing research in the field is essential as well as implementing higher education on physical activity management in Schools of Public Health.

Published
2015

10. Systematic Review and Meta-Analysis of Dietary Interventions and Microbiome in Phenylketonuria.

Author

Ubaldi F, Frangella C, Volpini V, Fortugno P, Valeriani F, and Romano Spica V

Subjects
Adult, Humans, Diet, Phenylketonurias complications, Gastrointestinal Microbiome
Abstract

Inborn errors of metabolism (IEMs) comprise a diverse group of monogenic disorders caused by enzyme deficiencies that result either in a toxic accumulation of metabolic intermediates or a shortage of essential end-products. Certain IEMs, like phenylketonuria (PKU), necessitate stringent dietary intervention that could lead to microbiome dysbiosis, thereby exacerbating the clinical phenotype. The objective of this systematic review was to examine the impact of PKU therapies on the intestinal microbiota. This research was conducted following the PRISMA Statement, with data from PubMed, Scopus, ScienceDirect, and Web of Science. A total of 18 articles meeting the inclusion criteria were published from 2011 to 2022. Significant reductions in several taxonomic groups in individuals with PKU when compared to the control group were detected in a quantitative analysis conducted across seven studies. The meta-analysis synthesis indicates a contrast in biodiversity between PKU subjects and the control population. Additionally, the meta-regression results, derived from the Bacillota/Bacteroidota ratio data, suggest a potential influence of diet in adult PKU populations ( p = 0.004). It is worth noting that the limited number of studies calls for further research and analysis in this area. Our findings indicate the necessity of enhancing understanding of microbiota variability in reaction to treatments among PKU subjects to design tailored therapeutic and nutritional interventions to prevent complications resulting from microbiota disruption.

Published
2023
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11. Air-dried smears for optimal diagnostic immunocytochemistry.

Author

Fulciniti F, Frangella C, Staiano M, La Vecchia F, Botti G, Demuru A, Magliulo G, and Boon ME

Subjects
Air, Antigen-Antibody Reactions, Ethanol, Fixatives, Formaldehyde, Humans, Reproducibility of Results, Biopsy, Fine-Needle, Desiccation, Immunohistochemistry, Specimen Handling methods, Tissue Fixation methods
Abstract

Objective: To exploit formalin-postfixed, air-dried smears for diagnostic immunocytochemistry (ICC)., Study Design: A series of 144 cases of diagnostic fine needle cytology samples in which air-dried, supplementary smears were available was used to exploit postfixation in the process of antigenic stabilization and rescue for immunocytochemical staining., Results: Postfixation with formalin and with a formalin/ethanol solution gave comparable results as far as recovery and immunocytochemical detection of most monoclonal and polyclonal antibodies. The visualization of the antibody reactions was often superior to that obtained with wet-fixed slides, probably due to the interaction of slow cell dehydration with their consequent optimal flattening observed with formalin postfixation after short rehydration in physiologic saline., Conclusion: Although wet fixation of cytopathologic slides in 95% ethanol represents a common standard for ICC, the usage of formalin-postfixed air-dried smears proved reliable and efficient for antigenic rescue and may enter routine usage in cytopathology laboratories. Moreover, in some instances, the visual evaluation of results was easier in the larger, well-flattened cells obtained in air-dried cells.

Published
2008
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