527 results on '"Dartigues, J.-F."'
Search Results
2. The French Model of Senior Housing to Tackle Housing Inequalities
- Author
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Boucaud-Maitre, D., Letenneur, L., Dartigues, J.-F., Amieva, H., and Tabue-Teguo, M.
- Published
- 2024
- Full Text
- View/download PDF
3. Social Vulnerability Predicts Frailty: Towards a Distinction between Fragility and Frailty?
- Author
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Amieva, Hélène, Ouvrard-Brouillou, C., Dartigues, J.-F., Pérès, K., Tabue Teguo, M., and Avila-Funes, A.
- Published
- 2022
- Full Text
- View/download PDF
4. Co-Occurrence of Geriatric Syndromes and Diseases in the General Population: Assessment of the Dimensions of Aging
- Author
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Dartigues, J.-F., Le Bourdonnec, K., Tabue-Teguo, M., Le Goff, M., Helmer, C., Avila-Funes, J. A., Coureau, G., Feart, C., Pérès, K., Genuer, R., Letenneur, L., Amieva, H., and Proust-Lima, Cécile
- Published
- 2022
- Full Text
- View/download PDF
5. A Literature Review of Healthy Aging Trajectories Through Quantitative and Qualitative Studies: A Psycho-Epidemiological Approach on Community-Dwelling Older Adults
- Author
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Zamudio-Rodríguez, Alfonso, Dartigues, J.-F., Amieva, H., and Pérès, K.
- Published
- 2021
- Full Text
- View/download PDF
6. Frailty Index, Hospital Admission and Number of Days Spent in Hospital in Nursing Home Residents: Results from the INCUR Study
- Author
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Simo, N., Cesari, M., Tchiero, H., Rolland, Y., De Souto Barreto, P., Dartigues, J. F., Vellas, B., and Tabue-Teguo, Maturin
- Published
- 2021
- Full Text
- View/download PDF
7. Older People Facing the Crisis of COVID-19: Between Fragility and Resilience
- Author
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Amieva, Helene, Avila-Funes, J.-A., Caillot-Ranjeva, S., Dartigues, J.-F., Koleck, M., Letenneur, L., Pech, M., Pérès, K., Raoux, N., Rascle, N., Ouvrard, C., Tabue-Teguo, M., Villeneuve, R., and Bergua, V.
- Published
- 2021
- Full Text
- View/download PDF
8. Targeted sequencing to identify novel genetic risk factors for deep vein thrombosis: a study of 734 genes
- Author
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de Haan, H.G., van Hylckama Vlieg, A., Lotta, L.A., Gorski, M.M., Bucciarelli, P., Martinelli, I., Baglin, T.P., Peyvandi, F., Rosendaal, F.R., Amouyel, P., de Andrade, M., Basu, S., Berr, C., Brody, J.A., Chasman, D. I, Dartigues, J.‐F., Folsom, A.R., Germain, M., Heit, J., Houwing‐Duitermaat, J., Kabrhel, C., Kraft, P., Le Gal, G., Lindström, S., Monajemi, R., Morange, P.‐E., Psaty, B.M., Reitsma, P.H., Ridker, P.M., Rose, L.M., Saut, N., Slagboom, E., Smadja, D., Smith, N.L., Suchon, P., Tang, W., Taylor, K.D., Trégouët, D.‐A., Tzourio, C., de Visser, M.C.H., Weng, L.‐C., and Wiggins, K.L.
- Published
- 2018
- Full Text
- View/download PDF
9. Psychosocioeconomic Precariousness and Frailty: The Respective Contribution in Predicting Mortality
- Author
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Ouvrard, Camille, Meillon, C., Dartigues, J.-F., Tabue Teguo, M., Avila-Funes, J. A., and Amieva, H.
- Published
- 2019
- Full Text
- View/download PDF
10. Dyspnea and 8-Year Mortality among Elderly Men and Women: The PAQUID Cohort Study
- Author
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Tessier, J. F., Nejjari, C., Letenneur, L., Filleul, L., Marty, M. L., Gateau, P. Barberger, and Dartigues, J. F.
- Published
- 2001
11. Mortality of Elderly Subjects with Self-Reported Asthma in a French Cohort, 1991-1996
- Author
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Dantzer, C., Tessier, J. F., Nejjari, C., Barberger-Gateau, P., and Dartigues, J. F.
- Published
- 2001
12. New insights into the genetic etiology of Alzheimer's disease and related dementias
- Author
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Bellenguez, C., Küçükali, F., Jansen, I. E., Kleineidam, L., Moreno-Grau, S., Amin, N., Naj, A. C., Campos-Martin, R., Grenier-Boley, B., Andrade, V., Holmans, P. A., Boland, A., Damotte, V., van der Lee, S. J., Costa, M. R., Kuulasmaa, T., Yang, Q., de Rojas, I., Bis, J. C., Yaqub, A., Prokic, I., Chapuis, J., Ahmad, S., Giedraitis, V., Aarsland, D., Garcia-Gonzalez, P., Abdelnour, C., Alarcón-Martín, E., Alcolea, D., Alegret, M., Alvarez, I., Álvarez, V., Armstrong, N. J., Tsolaki, A., Antúnez, C., Appollonio, I., Arcaro, M., Archetti, S., Pastor, A. A., Arosio, B., Athanasiu, L., Bailly, H., Banaj, N., Baquero, M., Barral, S., Beiser, A., Pastor, A. B., Below, J. E., Benchek, P., Benussi, L., Berr, C., Besse, C., Bessi, V., Binetti, G., Bizarro, A., Blesa, R., Boada, M., Boerwinkle, E., Borroni, B., Boschi, S., Bossù, P., Bråthen, G., Bressler, J., Bresner, C., Brodaty, H., Brookes, K. J., Brusco, L. I., Buiza-Rueda, D., Bûrger, K., Burholt, V., Bush, W. S., Calero, M., Cantwell, L. B., Chene, G., Chung, J., Cuccaro, M. L., Carracedo, Á., Cecchetti, R., Cervera-Carles, L., Charbonnier, C., Chen, H. -H., Chillotti, C., Ciccone, S., Claassen, J. A. H. R., Clark, C., Conti, E., Corma-Gómez, A., Costantini, E., Custodero, C., Daian, D., Dalmasso, M. C., Daniele, A., Dardiotis, E., Dartigues, J. -F., de Deyn, P. P., de Paiva Lopes, K., de Witte, L. D., Debette, S., Deckert, J., del Ser, T., Denning, N., Destefano, A., Dichgans, M., Diehl-Schmid, J., Diez-Fairen, M., Rossi, P. D., Djurovic, S., Duron, E., Düzel, E., Dufouil, C., Eiriksdottir, G., Engelborghs, S., Escott-Price, V., Espinosa, A., Ewers, M., Faber, K. M., Fabrizio, T., Nielsen, S. F., Fardo, D. W., Farotti, L., Fenoglio, C., Fernández-Fuertes, M., Ferrari, R., Ferreira, C. B., Ferri, E., Fin, B., Fischer, P., Fladby, T., Fließbach, K., Fongang, B., Fornage, M., Fortea, J., Foroud, T. M., Fostinelli, S., Fox, N. C., Franco-Macías, E., Bullido, M. J., Frank-García, A., Froelich, L., Fulton-Howard, B., Galimberti, D., García-Alberca, J. M., García-González, P., Garcia-Madrona, S., Garcia-Ribas, G., Ghidoni, R., Giegling, I., Giorgio, G., Goate, A. M., Goldhardt, O., Gomez-Fonseca, D., González-Pérez, A., Graff, C., Grande, G., Green, E., Grimmer, T., Grünblatt, E., Grunin, M., Gudnason, V., Guetta-Baranes, T., Haapasalo, A., Hadjigeorgiou, G., Haines, J. L., Hamilton-Nelson, K. L., Hampel, H., Hanon, O., Hardy, J., Hartmann, A. M., Hausner, L., Harwood, J., Heilmann-Heimbach, S., Helisalmi, S., Heneka, M. T., Hernández, I., Herrmann, M. J., Hoffmann, P., Holmes, C., Holstege, H., Vilas, R. H., Hulsman, M., Humphrey, J., Biessels, G. J., Jian, X., Johansson, C., Jun, G. R., Kastumata, Y., Kauwe, J., Kehoe, P. G., Kilander, L., Ståhlbom, A. K., Kivipelto, M., Koivisto, A., Kornhuber, J., Kosmidis, M. H., Kukull, W. A., Kuksa, P. P., Kunkle, B. W., Kuzma, A. B., Lage, C., Laukka, E. J., Launer, L., Lauria, A., Lee, C. -Y., Lehtisalo, J., Lerch, O., Lleó, A., Longstreth, W., Lopez, O., de Munain, A. L., Love, S., Löwemark, M., Luckcuck, L., Lunetta, K. L., Ma, Y., Macías, J., Macleod, C. A., Maier, W., Mangialasche, F., Spallazzi, M., Marquié, M., Marshall, R., Martin, E. R., Montes, A. M., Rodríguez, C. M., Masullo, C., Mayeux, R., Mead, S., Mecocci, P., Medina, M., Meggy, A., Mehrabian, S., Mendoza, S., Menéndez-González, M., Mir, P., Moebus, S., Mol, M., Molina-Porcel, L., Montrreal, L., Morelli, L., Moreno, F., Morgan, K., Mosley, T., Nöthen, M. M., Muchnik, C., Mukherjee, S., Nacmias, B., Ngandu, T., Nicolas, G., Nordestgaard, B. G., Olaso, R., Orellana, A., Orsini, M., Ortega, G., Padovani, A., Paolo, C., Papenberg, G., Parnetti, L., Pasquier, F., Pastor, P., Peloso, G., Pérez-Cordón, A., Pérez-Tur, J., Pericard, P., Peters, O., Pijnenburg, Y. A. L., Pineda, J. A., Piñol-Ripoll, G., Pisanu, C., Polak, T., Popp, J., Posthuma, D., Priller, J., Puerta, R., Quenez, O., Quintela, I., Thomassen, J. Q., Rábano, A., Rainero, I., Rajabli, F., Ramakers, I., Real, L. M., Reinders, M. J. T., Reitz, C., Reyes-Dumeyer, D., Ridge, P., Riedel-Heller, S., Riederer, P., Roberto, N., Rodriguez-Rodriguez, E., Rongve, A., Allende, I. R., Rosende-Roca, M., Royo, J. L., Rubino, E., Rujescu, D., Sáez, M. E., Sakka, P., Saltvedt, I., Sanabria, Á., Sánchez-Arjona, M. B., Sanchez-Garcia, F., Juan, P. S., Sánchez-Valle, R., Sando, S. B., Sarnowski, C., Satizabal, C. L., Scamosci, M., Scarmeas, N., Scarpini, E., Scheltens, P., Scherbaum, N., Scherer, M., Schmid, M., Schneider, A., Schott, J. M., Selbæk, G., Seripa, D., Serrano, M., Sha, J., Shadrin, A. A., Skrobot, O., Slifer, S., Snijders, G. J. L., Soininen, H., Solfrizzi, V., Solomon, A., Song, Y. E., Sorbi, S., Sotolongo-Grau, O., Spalletta, G., Spottke, A., Squassina, A., Stordal, E., Tartan, J. P., Tárraga, L., Tesí, N., Thalamuthu, A., Thomas, T., Tosto, G., Traykov, L., Tremolizzo, L., Tybjærg-Hansen, A., Uitterlinden, A., Ullgren, A., Ulstein, I., Valero, S., Valladares, O., Broeckhoven, C. V., Vance, J., Vardarajan, B. N., van der Lugt, A., Dongen, J. V., van Rooij, J., van Swieten, J., Vandenberghe, R., Verhey, F., Vidal, J. -S., Vogelgsang, J., Vyhnalek, M., Wagner, M., Wallon, D., Wang, L. -S., Wang, R., Weinhold, L., Wiltfang, J., Windle, G., Woods, B., Yannakoulia, M., Zare, H., Zhao, Y., Zhang, X., Zhu, C., Zulaica, M., Laczo, J., Matoska, V., Serpente, M., Assogna, F., Piras, F., Ciullo, V., Shofany, J., Ferrarese, C., Andreoni, S., Sala, G., Zoia, C. P., Zompo, M. D., Benussi, A., Bastiani, P., Takalo, M., Natunen, T., Laatikainen, T., Tuomilehto, J., Antikainen, R., Strandberg, T., Lindström, J., Peltonen, M., Abraham, R., Al-Chalabi, A., Bass, N. J., Brayne, C., Brown, K. S., Collinge, J., Craig, D., Deloukas, P., Fox, N., Gerrish, A., Gill, M., Gwilliam, R., Harold, D., Hollingworth, P., Johnston, J. A., Jones, L., Lawlor, B., Livingston, G., Lovestone, S., Lupton, M., Lynch, A., Mann, D., Mcguinness, B., Mcquillin, A., O’Donovan, M. C., Owen, M. J., Passmore, P., Powell, J. F., Proitsi, P., Rossor, M., Shaw, C. E., Smith, A. D., Gurling, H., Todd, S., Mummery, C., Ryan, N., Lacidogna, G., Adarmes-Gómez, A., Mauleón, A., Pancho, A., Gailhajenet, A., Lafuente, A., Macias-García, D., Martín, E., Pelejà, E., Carrillo, F., Merlín, I. S., Garrote-Espina, L., Vargas, L., Carrion-Claro, M., Marín, M., Labrador, M., Buendia, M., Alonso, M. D., Guitart, M., Moreno, M., Ibarria, M., Periñán, M., Aguilera, N., Gómez-Garre, P., Cañabate, P., Escuela, R., Pineda-Sánchez, R., Vigo-Ortega, R., Jesús, S., Preckler, S., Rodrigo-Herrero, S., Diego, S., Vacca, A., Roveta, F., Salvadori, N., Chipi, E., Boecker, H., Laske, C., Perneczky, R., Anastasiou, C., Janowitz, D., Malik, R., Anastasiou, A., Parveen, K., López-García, S., Antonell, A., Mihova, K. Y., Belezhanska, D., Weber, H., Kochen, S., Solis, P., Medel, N., Lisso, J., Sevillano, Z., Politis, D. G., Cores, V., Cuesta, C., Ortiz, C., Bacha, J. I., Rios, M., Saenz, A., Abalos, M. S., Kohler, E., Palacio, D. L., Etchepareborda, I., Kohler, M., Novack, G., Prestia, F. A., Galeano, P., Castaño, E. M., Germani, S., Toso, C. R., Rojo, M., Ingino, C., Mangone, C., Rubinsztein, D. C., Teipel, S., Fievet, N., Deramerourt, V., Forsell, C., Thonberg, H., Bjerke, M., Roeck, E. D., Martínez-Larrad, M. T., Olivar, N., Cano, A., Macias, J., Maroñas, O., Nuñez-Llaves, R., Olivé, C., Adarmes-Gómez, A. D., Amer-Ferrer, G., Antequera, M., Burguera, J. A., Casajeros, M. J., Martinez de Pancorbo, M., Hevilla, S., Espinosa, M. A. L., Legaz, A., Manzanares, S., Marín-Muñoz, J., Marín, T., Martínez, B., Martínez, V., Martínez-Lage Álvarez, P., Iriarte, M. M., Periñán-Tocino, M. T., Real de Asúa, D., Rodrigo, S., Sastre, I., Vicente, M. P., Vivancos, L., Epelbaum, J., Hannequin, D., Campion, D., Deramecourt, V., Tzourio, C., Brice, A., Dubois, B., Williams, A., Thomas, C., Davies, C., Nash, W., Dowzell, K., Morales, A. C., Bernardo-Harrington, M., Turton, J., Lord, J., Brown, K., Vardy, E., Fisher, E., Warren, J. D., Ryan, N. S., Guerreiro, R., Uphill, J., Bass, N., Heun, R., Kölsch, H., Schürmann, B., Lacour, A., Herold, C., Powell, J., Patel, Y., Hodges, A., Becker, T., Warden, D., Wilcock, G., Clarke, R., Ben-Shlomo, Y., Hooper, N. M., Pickering-Brown, S., Sussams, R., Warner, N., Bayer, A., Heuser, I., Drichel, D., Klopp, N., Mayhaus, M., Riemenschneider, M., Pinchler, S., Feulner, T., Gu, W., van den Bussche, H., Hüll, M., Frölich, L., Wichmann, H. -E., Jöckel, K. -H., O’Donovan, M., Owen, M., Bahrami, S., Bosnes, I., Selnes, P., Bergh, S., Palotie, A., Daly, M., Jacob, H., Matakidou, A., Runz, H., John, S., Plenge, R., Mccarthy, M., Hunkapiller, J., Ehm, M., Waterworth, D., Fox, C., Malarstig, A., Klinger, K., Call, K., Behrens, T., Loerch, P., Mäkelä, T., Kaprio, J., Virolainen, P., Pulkki, K., Kilpi, T., Perola, M., Partanen, J., Pitkäranta, A., Kaarteenaho, R., Vainio, S., Turpeinen, M., Serpi, R., Laitinen, T., Mäkelä, J., Kosma, V. -M., Kujala, U., Tuovila, O., Hendolin, M., Pakkanen, R., Waring, J., Riley-Gillis, B., Liu, J., Biswas, S., Diogo, D., Marshall, C., Hu, X., Gossel, M., Graham, R., Cummings, B., Ripatti, S., Schleutker, J., Arvas, M., Carpén, O., Hinttala, R., Kettunen, J., Mannermaa, A., Laukkanen, J., Julkunen, V., Remes, A., Kälviäinen, R., Peltola, J., Tienari, P., Rinne, J., Ziemann, A., Esmaeeli, S., Smaoui, N., Lehtonen, A., Eaton, S., Lahdenperä, S., van Adelsberg, J., Michon, J., Kerchner, G., Bowers, N., Teng, E., Eicher, J., Mehta, V., Gormley, P., Linden, K., Whelan, C., Xu, F., Pulford, D., Färkkilä, M., Pikkarainen, S., Jussila, A., Blomster, T., Kiviniemi, M., Voutilainen, M., Georgantas, B., Heap, G., Rahimov, F., Usiskin, K., Lu, T., Oh, D., Kalpala, K., Miller, M., Mccarthy, L., Eklund, K., Palomäki, A., Isomäki, P., Pirilä, L., Kaipiainen-Seppänen, O., Huhtakangas, J., Lertratanakul, A., Hochfeld, M., Bing, N., Gordillo, J. E., Mars, N., Pelkonen, M., Kauppi, P., Kankaanranta, H., Harju, T., Close, D., Greenberg, S., Chen, H., Betts, J., Ghosh, S., Salomaa, V., Niiranen, T., Juonala, M., Metsärinne, K., Kähönen, M., Junttila, J., Laakso, M., Pihlajamäki, J., Sinisalo, J., Taskinen, M. -R., Tuomi, T., Challis, B., Peterson, A., Chu, A., Parkkinen, J., Muslin, A., Joensuu, H., Meretoja, T., Aaltonen, L., Mattson, J., Auranen, A., Karihtala, P., Kauppila, S., Auvinen, P., Elenius, K., Popovic, R., Schutzman, J., Loboda, A., Chhibber, A., Lehtonen, H., Mcdonough, S., Crohns, M., Kulkarni, D., Kaarniranta, K., Turunen, J. A., Ollila, T., Seitsonen, S., Uusitalo, H., Aaltonen, V., Uusitalo-Järvinen, H., Luodonpää, M., Hautala, N., Loomis, S., Strauss, E., Podgornaia, A., Hoffman, J., Tasanen, K., Huilaja, L., Hannula-Jouppi, K., Salmi, T., Peltonen, S., Koulu, L., Harvima, I., Wu, Y., Choy, D., Pussinen, P., Salminen, A., Salo, T., Rice, D., Nieminen, P., Palotie, U., Siponen, M., Suominen, L., Mäntylä, P., Gursoy, U., Anttonen, V., Sipilä, K., Davis, J. W., Quarless, D., Petrovski, S., Wigmore, E., Chen, C. -Y., Bronson, P., Tsai, E., Huang, Y., Maranville, J., Shaikho, E., Mohammed, E., Wadhawan, S., Kvikstad, E., Caliskan, M., Chang, D., Bhangale, T., Pendergrass, S., Holzinger, E., Chen, X., Hedman, Å., King, K. S., Wang, C., Xu, E., Auge, F., Chatelain, C., Rajpal, D., Liu, D., Xia, T. -H., Brauer, M., Kurki, M., Karjalainen, J., Havulinna, A., Jalanko, A., Palta, P., della Briotta Parolo, P., Zhou, W., Lemmelä, S., Rivas, M., Harju, J., Lehisto, A., Ganna, A., Llorens, V., Laivuori, H., Rüeger, S., Niemi, M. E., Tukiainen, T., Reeve, M. P., Heyne, H., Palin, K., Garcia-Tabuenca, J., Siirtola, H., Kiiskinen, T., Lee, J., Tsuo, K., Elliott, A., Kristiansson, K., Hyvärinen, K., Ritari, J., Koskinen, M., Pylkäs, K., Kalaoja, M., Karjalainen, M., Mantere, T., Kangasniemi, E., Heikkinen, S., Laakkonen, E., Sipeky, C., Heron, S., Karlsson, A., Jambulingam, D., Rathinakannan, V. S., Kajanne, R., Aavikko, M., Jiménez, M. G., della Briotta Parola, P., Kanai, M., Kaunisto, M., Kilpeläinen, E., Sipilä, T. P., Brein, G., Awaisa, G., Shcherban, A., Donner, K., Loukola, A., Laiho, P., Sistonen, T., Kaiharju, E., Laukkanen, M., Järvensivu, E., Lähteenmäki, S., Männikkö, L., Wong, R., Mattsson, H., Hiekkalinna, T., Paajanen, T., Pärn, K., Gracia-Tabuenca, J., Abner, E., Adams, P. M., Aguirre, A., Albert, M. S., Albin, R. L., Allen, M., Alvarez, L., Apostolova, L. G., Arnold, S. E., Asthana, S., Atwood, C. S., Ayres, G., Baldwin, C. T., Barber, R. C., Barnes, L. L., Beach, T. G., Becker, J. T., Beecham, G. W., Beekly, D., Benitez, B. A., Bennett, D., Bertelson, J., Margaret, F. E., Bird, T. D., Blacker, D., Boeve, B. F., Bowen, J. D., Boxer, A., Brewer, J., Burke, J. R., Burns, J. M., Buxbaum, J. D., Cairns, N. J., Cao, C., Carlson, C. S., Carlsson, C. M., Carney, R. M., Carrasquillo, M. M., Chasse, S., Chesselet, M. -F., Chesi, A., Chin, N. A., Chui, H. C., Craft, S., Crane, P. K., Cribbs, D. H., Crocco, E. A., Cruchaga, C., Cullum, M., Darby, E., Davis, B., De Jager, P. L., Decarli, C., Detoledo, J., Dick, M., Dickson, D. W., Dombroski, B. A., Doody, R. S., Duara, R., Ertekin-Taner, N., Evans, D. A., Fairchild, T. J., Fallon, K. B., Farlow, M. R., Farrell, J. J., Fernandez-Hernandez, V., Ferris, S., Frosch, M. P., Galasko, D. R., Gamboa, A., Gearing, M., Geschwind, D. H., Ghetti, B., Gilbert, J. R., Grabowski, T. J., Graff-Radford, N. R., Grant, S. F. A., Green, R. C., Growdon, J. H., Hakonarson, H., Hall, J., Hamilton, R. L., Harari, O., Harrell, L. E., Haut, J., Head, E., Henderson, V. W., Hernandez, M., Hohman, T., Honig, L. S., Huebinger, R. M., Huentelman, M. J., Hulette, C. M., Hyman, B. T., Hynan, L. S., Ibanez, L., Jarvik, G. P., Jayadev, S., Jin, L. -W., Johnson, K., Johnson, L., Kamboh, M. I., Karydas, A. M., Katz, M. J., Kaye, J. A., Keene, C. D., Khaleeq, A., Kim, R., Knebl, J., Kowall, N. W., Kramer, J. H., Laferla, F. M., Lah, J. J., Larson, E. B., Lee, E. B., Lerner, A., Leung, Y. Y., Leverenz, J. B., Levey, A. I., Li, M., Lieberman, A. P., Lipton, R. B., Logue, M., Lyketsos, C. G., Malamon, J., Mains, D., Marson, D. C., Martiniuk, F., Mash, D. C., Masliah, E., Massman, P., Masurkar, A., Mccormick, W. C., Mccurry, S. M., Mcdavid, A. N., Mckee, A. C., Mesulam, M., Mez, J., Miller, B. L., Miller, C. A., Miller, J. W., Montine, T. J., Monuki, E. S., Morris, J. C., Myers, A. J., Nguyen, T., O’Bryant, S., Olichney, J. M., Ory, M., Palmer, R., Parisi, J. E., Paulson, H. L., Pavlik, V., Paydarfar, D., Perez, V., Peskind, E., Petersen, R. C., Phillips-Cremins, J. E., Pierce, A., Polk, M., Poon, W. W., Potter, H., Qu, L., Quiceno, M., Quinn, J. F., Raj, A., Raskind, M., Reiman, E. M., Reisberg, B., Reisch, J. S., Ringman, J. M., Roberson, E. D., Rodriguear, M., Rogaeva, E., Rosen, H. J., Rosenberg, R. N., Royall, D. R., Sager, M. A., Sano, M., Saykin, A. J., Schneider, J. A., Schneider, L. S., Seeley, W. W., Small, S., Smith, A. G., Smith, J. P., Sonnen, J. A., Spina, S., George-Hyslop, P. 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M, Rossi, P, Djurovic, S, Duron, E, Düzel, E, Dufouil, C, Eiriksdottir, G, Engelborghs, S, Escott-Price, V, Espinosa, A, Ewers, M, Faber, K, Fabrizio, T, Nielsen, S, Fardo, D, Farotti, L, Fenoglio, C, Fernández-Fuertes, M, Ferrari, R, Ferreira, C, Ferri, E, Fin, B, Fischer, P, Fladby, T, Fließbach, K, Fongang, B, Fornage, M, Fortea, J, Foroud, T, Fostinelli, S, Fox, N, Franco-Macías, E, Bullido, M, Frank-García, A, Froelich, L, Fulton-Howard, B, Galimberti, D, García-Alberca, J, García-González, P, Garcia-Madrona, S, Garcia-Ribas, G, Ghidoni, R, Giegling, I, Giorgio, G, Goate, A, Goldhardt, O, Gomez-Fonseca, D, González-Pérez, A, Graff, C, Grande, G, Green, E, Grimmer, T, Grünblatt, E, Grunin, M, Gudnason, V, Guetta-Baranes, T, Haapasalo, A, Hadjigeorgiou, G, Haines, J, Hamilton-Nelson, K, Hampel, H, Hanon, O, Hardy, J, Hartmann, A, Hausner, L, Harwood, J, Heilmann-Heimbach, S, Helisalmi, S, Heneka, M, Hernández, I, Herrmann, M, Hoffmann, P, Holmes, C, Holstege, H, Vilas, R, Hulsman, M, Humphrey, J, Biessels, G, Jian, X, Johansson, C, Jun, G, Kastumata, Y, Kauwe, J, Kehoe, P, Kilander, L, Ståhlbom, A, Kivipelto, M, Koivisto, A, Kornhuber, J, Kosmidis, M, Kukull, W, Kuksa, P, Kunkle, B, Kuzma, A, Lage, C, Laukka, E, Launer, L, Lauria, A, Lee, C, Lehtisalo, J, Lerch, O, Lleó, A, Longstreth, W, Lopez, O, de Munain, A, Love, S, Löwemark, M, Luckcuck, L, Lunetta, K, Ma, Y, Macías, J, Macleod, C, Maier, W, Mangialasche, F, Spallazzi, M, Marquié, M, Marshall, R, Martin, E, Montes, A, Rodríguez, C, Masullo, C, Mayeux, R, Mead, S, Mecocci, P, Medina, M, Meggy, A, Mehrabian, S, Mendoza, S, Menéndez-González, M, Mir, P, Moebus, S, Mol, M, Molina-Porcel, L, Montrreal, L, Morelli, L, Moreno, F, Morgan, K, Mosley, T, Nöthen, M, Muchnik, C, Mukherjee, S, Nacmias, B, Ngandu, T, Nicolas, G, Nordestgaard, B, Olaso, R, Orellana, A, Orsini, M, Ortega, G, Padovani, A, Paolo, C, Papenberg, G, Parnetti, L, Pasquier, F, Pastor, P, Peloso, G, Pérez-Cordón, A, Pérez-Tur, J, Pericard, P, Peters, O, Pijnenburg, Y, Pineda, J, Piñol-Ripoll, G, Pisanu, C, Polak, T, Popp, J, Posthuma, D, Priller, J, Puerta, R, Quenez, O, Quintela, I, Thomassen, J, Rábano, A, Rainero, I, Rajabli, F, Ramakers, I, Real, L, Reinders, M, Reitz, C, Reyes-Dumeyer, D, Ridge, P, Riedel-Heller, S, Riederer, P, Roberto, N, Rodriguez-Rodriguez, E, Rongve, A, Allende, I, Rosende-Roca, M, Royo, J, Rubino, E, Rujescu, D, Sáez, M, Sakka, P, Saltvedt, I, Sanabria, Á, Sánchez-Arjona, M, Sanchez-Garcia, F, Juan, P, Sánchez-Valle, R, Sando, S, Sarnowski, C, Satizabal, C, Scamosci, M, Scarmeas, N, Scarpini, E, Scheltens, P, Scherbaum, N, Scherer, M, Schmid, M, Schneider, A, Schott, J, Selbæk, G, Seripa, D, Serrano, M, Sha, J, Shadrin, A, Skrobot, O, Slifer, S, Snijders, G, Soininen, H, Solfrizzi, V, Solomon, A, Song, Y, Sorbi, S, Sotolongo-Grau, O, Spalletta, G, Spottke, A, Squassina, A, Stordal, E, Tartan, J, Tárraga, L, Tesí, N, Thalamuthu, A, Thomas, T, Tosto, G, Traykov, L, Tremolizzo, L, Tybjærg-Hansen, A, Uitterlinden, A, Ullgren, A, Ulstein, I, Valero, S, Valladares, O, Broeckhoven, C, Vance, J, Vardarajan, B, van der Lugt, A, Dongen, J, van Rooij, J, van Swieten, J, Vandenberghe, R, Verhey, F, Vidal, J, Vogelgsang, J, Vyhnalek, M, Wagner, M, Wallon, D, Wang, L, Wang, R, Weinhold, L, Wiltfang, J, Windle, G, Woods, B, Yannakoulia, M, Zare, H, Zhao, Y, Zhang, X, Zhu, C, Zulaica, M, Andreoni, S, Ferrarese, C, Sala, G, Zoia, C, Farrer, L, Psaty, B, Ghanbari, M, Raj, T, Sachdev, P, Mather, K, Jessen, F, Ikram, M, de Mendonça, A, Hort, J, Tsolaki, M, Pericak-Vance, M, Amouyel, P, Williams, J, Frikke-Schmidt, R, Clarimon, J, Deleuze, J, Rossi, G, Seshadri, S, Andreassen, O, Ingelsson, M, Hiltunen, M, Sleegers, K, Schellenberg, G, van Duijn, C, Sims, R, van der Flier, W, Ruiz, A, Ramirez, A, Lambert, J, VU University medical center, Amsterdam Neuroscience - Neurodegeneration, Neurology, Human genetics, Amsterdam Neuroscience - Complex Trait Genetics, Amsterdam Neuroscience - Compulsivity, 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Spec Psychiatrie (9), UAM. Departamento de Biología Molecular, University of Helsinki, Department of Neurosciences, HUS Internal Medicine and Rehabilitation, Timo Strandberg / Principal Investigator, Department of Medicine, Clinicum, HUS Neurocenter, Neurologian yksikkö, Centre of Excellence in Complex Disease Genetics, HUS Abdominal Center, Institut Pasteur, Institut National de la Santé et de la Recherche Médicale (France), European Commission, LabEx DISTALZ, Pérez-Tur, Jordi, University Children’s Hospital Basel (Suiza), INSERM (Francia), Lille Métropole Communauté Urbaine, Government of France (Francia), EADB, GR@ACE, DEGESCO, EADI, GERAD, Demgene, FinnGen, ADGC, CHARGE, Holmans, Peter A. [0000-0003-0870-9412], van der Lee, Sven J. [0000-0003-1606-8643], Costa, Marcos R. [0000-0002-4928-2163], Bis, Joshua C. [0000-0002-3409-1110], Brookes, Keeley J. [0000-0003-2427-2513], Bush, William S. [0000-0002-9729-6519], de Witte, Lot D. [0000-0002-7235-9958], del Ser, Teodoro [0000-0001-9806-7083], Fox, Nick C. [0000-0002-6660-657X], Bullido, María J. [0000-0002-6477-1117], Goate, Alison M. [0000-0002-0576-2472], Herrmann, Martin J. [0000-0001-9970-2122], Jun, Gyungah R. [0000-0002-3230-8697], Kehoe, Patrick G. [0000-0002-7542-1139], Kosmidis, Mary H. [0000-0001-8790-1220], Lunetta, Kathryn L. [0000-0002-9268-810X], MacLeod, Catherine A. [0000-0002-9314-7380], Nöthen, Markus M. [0000-0002-8770-2464], Nordestgaard, Børge G. [0000-0002-1954-7220], Pineda, Juan A. [0000-0002-3751-0296], Real, Luis M. [0000-0003-4932-7429], Reinders, Marcel J. T. [0000-0002-1148-1562], Satizabal, Claudia L. [0000-0002-1115-4430], Schott, Jonathan M. [0000-0003-2059-024X], Shadrin, Alexey A. [0000-0002-7467-250X], Farrer, Lindsay A. [0000-0001-5533-4225], Psaty, Bruce M. [0000-0002-7278-2190], Ikram, M. Arfan [0000-0003-0372-8585], Pericak-Vance, Margaret A. [0000-0001-7283-8804], Andreassen, Ole A. [0000-0002-4461-3568], van Duijn, Cornelia M. [0000-0002-2374-9204], van der Flier, Wiesje M. [0000-0001-8766-6224], and Molecular Neuroscience and Ageing Research (MOLAR)
- Subjects
tau Proteins/genetics ,Alzheimer`s disease Donders Center for Medical Neuroscience [Radboudumc 1] ,Neurologi ,MED/03 - GENETICA MEDICA ,45/43 ,Medizin ,Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13] ,genetics [Alzheimer Disease] ,Genome-Wide Association Study ,Humans ,tau Proteins ,Alzheimer Disease ,Cognitive Dysfunction ,VARIANTS ,pathology [Alzheimer Disease] ,Tau Proteins ,Settore BIO/13 - Biologia Applicata ,Cognitive Dysfunction/psychology ,692/699/375/365/1283 ,IMPUTATION ,article ,1184 Genetics, developmental biology, physiology ,Biología y Biomedicina / Biología ,AMYLOID-BETA ,Settore MED/26 - NEUROLOGIA ,Neurology ,psychology [Cognitive Dysfunction] ,Medical Genetics ,Human ,Neuroscience(all) ,631/208/205/2138 ,All institutes and research themes of the Radboud University Medical Center ,SDG 3 - Good Health and Well-being ,ddc:570 ,Genetics ,Genetic Predisposition to Disease ,GENOME-WIDE ASSOCIATION ,METAANALYSIS ,Medicinsk genetik ,MED/26 - NEUROLOGIA ,Alzheimer Disease/genetics ,neurology ,tau Protein ,NECROSIS-FACTOR-ALPHA ,RISK LOCI ,genetics [tau Proteins] ,PREDICTION MODELS ,Human medicine ,GENERATION ,RESPONSES - Abstract
25 páginas, 6 figuras, 2 tablas, Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele., This work was funded by a grant (EADB) from the EU Joint Programme – Neurodegenerative Disease Research. INSERM UMR1167 is also funded by the INSERM, Institut Pasteur de Lille, Lille Métropole Communauté Urbaine and French government’s LABEX DISTALZ program (development of innovative strategies for a transdisciplinary approach to AD). Full consortium acknowledgements and funding are in the Supplementary Not
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- 2022
13. 17q21.31 duplication causes prominent tau-related dementia with increased MAPT expression
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Le Guennec, K, Quenez, O, Nicolas, G, Wallon, D, Rousseau, S, Richard, A-C, Alexander, J, Paschou, P, Charbonnier, C, Bellenguez, C, Grenier-Boley, B, Lechner, D, Bihoreau, M-T, Olaso, R, Boland, A, Meyer, V, Deleuze, J-F, Amouyel, P, Munter, H M, Bourque, G, Lathrop, M, Frebourg, T, Redon, R, Letenneur, L, Dartigues, J-F, Martinaud, O, Kalev, O, Mehrabian, S, Traykov, L, Ströbel, T, Le Ber, I, Caroppo, P, Epelbaum, S, Jonveaux, T, Pasquier, F, Rollin-Sillaire, A, Génin, E, Guyant-Maréchal, L, Kovacs, G G, Lambert, J-C, Hannequin, D, Campion, D, and Rovelet-Lecrux, A
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- 2017
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14. SORL1 rare variants: a major risk factor for familial early-onset Alzheimer’s disease
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Nicolas, G, Charbonnier, C, Wallon, D, Quenez, O, Bellenguez, C, Grenier-Boley, B, Rousseau, S, Richard, A-C, Rovelet-Lecrux, A, Le Guennec, K, Bacq, D, Garnier, J-G, Olaso, R, Boland, A, Meyer, V, Deleuze, J-F, Amouyel, P, Munter, H M, Bourque, G, Lathrop, M, Frebourg, T, Redon, R, Letenneur, L, Dartigues, J-F, Génin, E, Lambert, J-C, Hannequin, D, and Campion, D
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- 2016
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15. Why is later age at retirement beneficial for cognition? Results from a French population-based study
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Grotz, Catherine, Meillon, C., Amieva, H., Stern, Y., Dartigues, J.-F., Adam, S., and Letenneur, L.
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- 2016
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16. A novel Alzheimer disease locus located near the gene encoding tau protein
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Jun, G, Ibrahim-Verbaas, C A, Vronskaya, M, Lambert, J-C, Chung, J, Naj, A C, Kunkle, B W, Wang, L-S, Bis, J C, Bellenguez, C, Harold, D, Lunetta, K L, Destefano, A L, Grenier-Boley, B, Sims, R, Beecham, G W, Smith, A V, Chouraki, V, Hamilton-Nelson, K L, Ikram, M A, Fievet, N, Denning, N, Martin, E R, Schmidt, H, Kamatani, Y, Dunstan, M L, Valladares, O, Laza, A R, Zelenika, D, Ramirez, A, Foroud, T M, Choi, S-H, Boland, A, Becker, T, Kukull, W A, van der Lee, S J, Pasquier, F, Cruchaga, C, Beekly, D, Fitzpatrick, A L, Hanon, O, Gill, M, Barber, R, Gudnason, V, Campion, D, Love, S, Bennett, D A, Amin, N, Berr, C, Tsolaki, Magda, Buxbaum, J D, Lopez, O L, Deramecourt, V, Fox, N C, Cantwell, L B, Tárraga, L, Dufouil, C, Hardy, J, Crane, P K, Eiriksdottir, G, Hannequin, D, Clarke, R, Evans, D, Mosley, Jr., T H, Letenneur, L, Brayne, C, Maier, W, De Jager, P, Emilsson, V, Dartigues, J-F, Hampel, H, Kamboh, M I, de Bruijn, R F A G, Tzourio, C, Pastor, P, Larson, E B, Rotter, J I, O'Donovan, M C, Montine, T J, Nalls, M A, Mead, S, Reiman, E M, Jonsson, P V, Holmes, C, St George-Hyslop, P H, Boada, M, Passmore, P, Wendland, J R, Schmidt, R, Morgan, K, Winslow, A R, Powell, J F, Carasquillo, M, Younkin, S G, Jakobsdóttir, J, Kauwe, J S K, Wilhelmsen, K C, Rujescu, D, Nöthen, M M, Hofman, A, Jones, L, Haines, J L, Psaty, B M, Van Broeckhoven, C, Holmans, P, Launer, L J, Mayeux, R, Lathrop, M, Goate, A M, Escott-Price, V, Seshadri, S, Pericak-Vance, M A, Amouyel, P, Williams, J, van Duijn, C M, Schellenberg, G D, and Farrer, L A
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- 2016
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17. ETNA3, a clinical randomized study assessing three cognitive-oriented therapies in dementia: Rationale and general design
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Amieva, H. and Dartigues, J.-F.
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- 2013
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18. The impact of chronic psychiatric disorders on cognitive decline
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Villeneuve, R., Blanchard, C., Rullier, L., Raoux, N., Bergua, V., Dartigues, J.‐F., Pérès, K., and Amieva, H.
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- 2017
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19. Diet, alcohol consumption and cognitive disorders in Central Africa: A study from the EPIDEMCA program
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Pilleron, S., Desport, Jean-Claude, Jésus, P., Mbelesso, P., Ndamba-Bandzouzi, B., Dartigues, J. -F., Clément, J. -P., Preux, P. -M., Guerchet, M., and For the EPIDEMCA Group
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- 2015
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20. A genome-wide association meta-analysis of plasma Aβ peptides concentrations in the elderly
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Chouraki, V, De Bruijn, R F A G, Chapuis, J, Bis, J C, Reitz, C, Schraen, S, Ibrahim-Verbaas, C A, Grenier-Boley, B, Delay, C, Rogers, R, Demiautte, F, Mounier, A, Fitzpatrick, A L, Berr, C, Dartigues, J-F, Uitterlinden, A G, Hofman, A, Breteler, M, Becker, J T, Lathrop, M, Schupf, N, Alpérovitch, A, Mayeux, R, van Duijn, C M, Buée, L, Amouyel, P, Lopez, O L, Ikram, M A, Tzourio, C, and Lambert, J-C
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- 2014
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21. Change in leisure and social activities and risk of dementia in elderly cohort
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Foubert-Samier, A., Le Goff, M., Helmer, C., Pérès, K., Orgogozo, J. -M., Barberger-Gateau, P., Amieva, H., and Dartigues, J. -F.
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- 2014
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22. New insights into the genetic etiology of Alzheimer's disease and related dementias
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Bellenguez, C. Küçükali, F. Jansen, I.E. Kleineidam, L. Moreno-Grau, S. Amin, N. Naj, A.C. Campos-Martin, R. Grenier-Boley, B. Andrade, V. Holmans, P.A. Boland, A. Damotte, V. van der Lee, S.J. Costa, M.R. Kuulasmaa, T. Yang, Q. de Rojas, I. Bis, J.C. Yaqub, A. Prokic, I. Chapuis, J. Ahmad, S. Giedraitis, V. Aarsland, D. Garcia-Gonzalez, P. Abdelnour, C. Alarcón-Martín, E. Alcolea, D. Alegret, M. Alvarez, I. Álvarez, V. Armstrong, N.J. Tsolaki, A. Antúnez, C. Appollonio, I. Arcaro, M. Archetti, S. Pastor, A.A. Arosio, B. Athanasiu, L. Bailly, H. Banaj, N. Baquero, M. Barral, S. Beiser, A. Pastor, A.B. Below, J.E. Benchek, P. Benussi, L. Berr, C. Besse, C. Bessi, V. Binetti, G. Bizarro, A. Blesa, R. Boada, M. Boerwinkle, E. Borroni, B. Boschi, S. Bossù, P. Bråthen, G. Bressler, J. Bresner, C. Brodaty, H. Brookes, K.J. Brusco, L.I. Buiza-Rueda, D. Bûrger, K. Burholt, V. Bush, W.S. Calero, M. Cantwell, L.B. Chene, G. Chung, J. Cuccaro, M.L. Carracedo, Á. Cecchetti, R. Cervera-Carles, L. Charbonnier, C. Chen, H.-H. Chillotti, C. Ciccone, S. Claassen, J.A.H.R. Clark, C. Conti, E. Corma-Gómez, A. Costantini, E. Custodero, C. Daian, D. Dalmasso, M.C. Daniele, A. Dardiotis, E. Dartigues, J.-F. de Deyn, P.P. de Paiva Lopes, K. de Witte, L.D. Debette, S. Deckert, J. Del Ser, T. Denning, N. DeStefano, A. Dichgans, M. Diehl-Schmid, J. Diez-Fairen, M. Rossi, P.D. Djurovic, S. Duron, E. Düzel, E. Dufouil, C. Eiriksdottir, G. Engelborghs, S. Escott-Price, V. Espinosa, A. Ewers, M. Faber, K.M. Fabrizio, T. Nielsen, S.F. Fardo, D.W. Farotti, L. Fenoglio, C. Fernández-Fuertes, M. Ferrari, R. Ferreira, C.B. Ferri, E. Fin, B. Fischer, P. Fladby, T. Fließbach, K. Fongang, B. Fornage, M. Fortea, J. Foroud, T.M. Fostinelli, S. Fox, N.C. Franco-Macías, E. Bullido, M.J. Frank-García, A. Froelich, L. Fulton-Howard, B. Galimberti, D. García-Alberca, J.M. García-González, P. Garcia-Madrona, S. Garcia-Ribas, G. Ghidoni, R. Giegling, I. Giorgio, G. Goate, A.M. Goldhardt, O. Gomez-Fonseca, D. González-Pérez, A. Graff, C. Grande, G. Green, E. Grimmer, T. Grünblatt, E. Grunin, M. Gudnason, V. Guetta-Baranes, T. Haapasalo, A. Hadjigeorgiou, G. Haines, J.L. Hamilton-Nelson, K.L. Hampel, H. Hanon, O. Hardy, J. Hartmann, A.M. Hausner, L. Harwood, J. Heilmann-Heimbach, S. Helisalmi, S. Heneka, M.T. Hernández, I. Herrmann, M.J. Hoffmann, P. Holmes, C. Holstege, H. Vilas, R.H. Hulsman, M. Humphrey, J. Biessels, G.J. Jian, X. Johansson, C. Jun, G.R. Kastumata, Y. Kauwe, J. Kehoe, P.G. Kilander, L. Ståhlbom, A.K. Kivipelto, M. Koivisto, A. Kornhuber, J. Kosmidis, M.H. Kukull, W.A. Kuksa, P.P. Kunkle, B.W. Kuzma, A.B. Lage, C. Laukka, E.J. Launer, L. Lauria, A. Lee, C.-Y. Lehtisalo, J. Lerch, O. Lleó, A. Longstreth, W., Jr Lopez, O. de Munain, A.L. Love, S. Löwemark, M. Luckcuck, L. Lunetta, K.L. Ma, Y. Macías, J. MacLeod, C.A. Maier, W. Mangialasche, F. Spallazzi, M. Marquié, M. Marshall, R. Martin, E.R. Montes, A.M. Rodríguez, C.M. Masullo, C. Mayeux, R. Mead, S. Mecocci, P. Medina, M. Meggy, A. Mehrabian, S. Mendoza, S. Menéndez-González, M. Mir, P. Moebus, S. Mol, M. Molina-Porcel, L. Montrreal, L. Morelli, L. Moreno, F. Morgan, K. Mosley, T. Nöthen, M.M. Muchnik, C. Mukherjee, S. Nacmias, B. Ngandu, T. Nicolas, G. Nordestgaard, B.G. Olaso, R. Orellana, A. Orsini, M. Ortega, G. Padovani, A. Paolo, C. Papenberg, G. Parnetti, L. Pasquier, F. Pastor, P. Peloso, G. Pérez-Cordón, A. Pérez-Tur, J. Pericard, P. Peters, O. Pijnenburg, Y.A.L. Pineda, J.A. Piñol-Ripoll, G. Pisanu, C. Polak, T. Popp, J. Posthuma, D. Priller, J. Puerta, R. Quenez, O. Quintela, I. Thomassen, J.Q. Rábano, A. Rainero, I. Rajabli, F. Ramakers, I. Real, L.M. Reinders, M.J.T. Reitz, C. Reyes-Dumeyer, D. Ridge, P. Riedel-Heller, S. Riederer, P. Roberto, N. Rodriguez-Rodriguez, E. Rongve, A. Allende, I.R. Rosende-Roca, M. Royo, J.L. Rubino, E. Rujescu, D. Sáez, M.E. Sakka, P. Saltvedt, I. Sanabria, Á. Sánchez-Arjona, M.B. Sanchez-Garcia, F. Juan, P.S. Sánchez-Valle, R. Sando, S.B. Sarnowski, C. Satizabal, C.L. Scamosci, M. Scarmeas, N. Scarpini, E. Scheltens, P. Scherbaum, N. Scherer, M. Schmid, M. Schneider, A. Schott, J.M. Selbæk, G. Seripa, D. Serrano, M. Sha, J. Shadrin, A.A. Skrobot, O. Slifer, S. Snijders, G.J.L. Soininen, H. Solfrizzi, V. Solomon, A. Song, Y. Sorbi, S. Sotolongo-Grau, O. Spalletta, G. Spottke, A. Squassina, A. Stordal, E. Tartan, J.P. Tárraga, L. Tesí, N. Thalamuthu, A. Thomas, T. Tosto, G. Traykov, L. Tremolizzo, L. Tybjærg-Hansen, A. Uitterlinden, A. Ullgren, A. Ulstein, I. Valero, S. Valladares, O. Broeckhoven, C.V. Vance, J. Vardarajan, B.N. van der Lugt, A. Dongen, J.V. van Rooij, J. van Swieten, J. Vandenberghe, R. Verhey, F. Vidal, J.-S. Vogelgsang, J. Vyhnalek, M. Wagner, M. Wallon, D. Wang, L.-S. Wang, R. Weinhold, L. Wiltfang, J. Windle, G. Woods, B. Yannakoulia, M. Zare, H. Zhao, Y. Zhang, X. Zhu, C. Zulaica, M. Farrer, L.A. Psaty, B.M. Ghanbari, M. Raj, T. Sachdev, P. Mather, K. Jessen, F. Ikram, M.A. de Mendonça, A. Hort, J. Tsolaki, M. Pericak-Vance, M.A. Amouyel, P. Williams, J. Frikke-Schmidt, R. Clarimon, J. Deleuze, J.-F. Rossi, G. Seshadri, S. Andreassen, O.A. Ingelsson, M. Hiltunen, M. Sleegers, K. Schellenberg, G.D. van Duijn, C.M. Sims, R. van der Flier, W.M. Ruiz, A. Ramirez, A. Lambert, J.-C. EADB GR@ACE DEGESCO EADI GERAD Demgene FinnGen ADGC CHARGE
- Abstract
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele. © 2022. The Author(s).
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- 2022
23. Analysing time to event data in dementia prevention trials: The example of the guidage study of EGB761®
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Scherrer, Bruno, Andrieu, S., Ousset, P.-J., Berrut, G., Dartigues, J.-F., Dubois, B., Pasquier, F., Piette, F., Robert, P., Touchon, J., Garnier, P., Mathiex-Fortunet, H., Vellas, B., and The Guidage Study Group
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- 2015
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24. Hierarchical structure of the activities of daily living scale in dementia
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Delva, F., Edjolo, A., Peres, K., Berr, C., Barberger-Gateau, P., and Dartigues, J. F.
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- 2014
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25. Becoming a nonagenarian: Factors associated with survival up to 90 years old in 70+ men and women. Results from the paquid longitudinal cohort
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Edjolo, Arlette, Helmer, C., Barberger-Gateau, P., Dartigues, J. -F., Maubaret, C., and Peres, K.
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- 2013
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26. Risk Factors among Elderly for Short Term Deaths Related to High Levels of Air Pollution
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Filleul, L., Baldi, I., Dartigues, J.-F., and Tessier, J.-F.
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- 2003
27. Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype
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Vermunt, L., Sikkes, S. A. M., van den Hout, A., Handels, R., Bos, I., van der Flier, W. M., Kern, S., Ousset, P. -J., Maruff, P., Skoog, I., Verhey, F. R. J., Freund-Levi, Y., Tsolaki, M., Wallin, A. K., Olde Rikkert, M., Soininen, H., Spiru, L., Zetterberg, H., Blennow, K., Scheltens, P., Muniz-Terrera, G., Visser, P. J., Vellas, B., Reynish, E., Ousset, P. J., Andrieu, S., Burns, A., Pasquier, F., Frisoni, G., Salmon, E., Michel, J. P., Zekry, D. S., Boada, M., Dartigues, J. F., Olde-Rikkert, M. G. M., Rigaud, A. S., Winblad, B., Malick, A., Sinclair, A., Frolich, L., Ribera, C., Touchon, J., Robert, P., Salva, A., Waldemar, G., Bullock, R., Rodriguez, G., Jones, R. W., Stiens, G., Stoppe, G., Eriksdotter Jonhagen, M., Cherubini, A., Lage, P. M., Gomez-Isla, T., Camus, V., Aguera-Morales, E., Lopez, F., Savy, S., Cantet, C., Coley, N., Psychiatrie & Neuropsychologie, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, MUMC+: MA Med Staf Spec Psychiatrie (9), Neurology, Amsterdam Neuroscience - Neurodegeneration, NCA - neurodegeneration, APH - Personalized Medicine, APH - Methodology, Epidemiology and Data Science, Clinical Neuropsychology, and Zekry Berger, Dina Selma
- Subjects
0301 basic medicine ,Apolipoprotein E ,Oncology ,Male ,NATIONAL INSTITUTE ,MILD COGNITIVE IMPAIRMENT ,Neurology ,Alzheimer`s disease Donders Center for Medical Neuroscience [Radboudumc 1] ,Time Factors ,Epidemiology ,Apolipoprotein E4 ,Disease ,RECOMMENDATIONS ,0302 clinical medicine ,Cerebrospinal fluid ,Genotype ,Longitudinal Studies ,Apolipoprotein E4/genetics ,Stage (cooking) ,Progression ,Health Policy ,Cognitive Dysfunction/pathology ,NEURODEGENERATION ,Alzheimer's disease ,Preclinical ,3. Good health ,PREVALENCE ,Psychiatry and Mental health ,Disease Progression ,lipids (amino acids, peptides, and proteins) ,Female ,ASSOCIATION WORKGROUPS ,APOE ,medicine.medical_specialty ,Amyloid ,Multistate model ,BETA-AMYLOID 1-42 ,Prodromal Symptoms ,tau Proteins ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,Sex Factors ,Developmental Neuroscience ,SDG 3 - Good Health and Well-being ,Alzheimer Disease ,Internal medicine ,mental disorders ,medicine ,Dementia ,Humans ,Biomarkers/cerebrospinal fluid ,Cognitive Dysfunction ,Alleles ,Aged ,Disease duration ,DECLINE ,business.industry ,tau Proteins/cerebrospinal fluid ,Alzheimer Disease/genetics/pathology ,medicine.disease ,Institutional repository ,Clinical setting ,030104 developmental biology ,Prodromal ,Positron-Emission Tomography ,ddc:618.97 ,RISK-FACTORS ,DIAGNOSTIC GUIDELINES ,Neurology (clinical) ,Geriatrics and Gerontology ,business ,030217 neurology & neurosurgery ,Biomarkers - Abstract
Introduction: We estimated the age-specific duration of the preclinical, prodromal, and dementia stages of Alzheimer's disease (AD) and the influence of sex, setting, apolipoprotein E (APOE) genotype, and cerebrospinal fluid tau on disease duration.Methods: We performed multistate modeling in a combined sample of 6 cohorts (n = 3268) with death as the end stage and estimated the preclinical, prodromal, and dementia stage duration.Results: The overall AD duration varied between 24 years (age 60) and 15 years (age 80). For individuals presenting with preclinical AD, age 70, the estimated preclinical AD duration was 10 years, prodromal AD 4 years, and dementia 6 years. Male sex, clinical setting, APOE epsilon 4 allele carriership, and abnormal cerebrospinal fluid tau were associated with a shorter duration, and these effects depended on disease stage.Discussion: Estimates of AD disease duration become more accurate if age, sex, setting, APOE, and cerebrospinal fluid tau are taken into account. This will be relevant for clinical practice and trial design. (C) 2019 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
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- 2019
28. Recommendations for ICT use in Alzheimer’s disease assessment: Monaco CTAD expert meeting
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Robert, Philippe H., Konig, A., Andrieu, S., Bremond, F., Chemin, I., Chung, P. C., Dartigues, J. F., Dubois, B., Feutren, G., Guillemaud, R., Kenisberg, P. A., Nave, S., Vellas, B., Verhey, F., Yesavage, J., and Mallea, P.
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- 2013
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29. High frequency of potentially pathogenic SORL1 mutations in autosomal dominant early-onset Alzheimer disease
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Pottier, C, Hannequin, D, Coutant, S, Rovelet-Lecrux, A, Wallon, D, Rousseau, S, Legallic, S, Paquet, C, Bombois, S, Pariente, J, Thomas-Anterion, C, Michon, A, Croisile, B, Etcharry-Bouyx, F, Berr, C, Dartigues, J-F, Amouyel, P, Dauchel, H, Boutoleau-Bretonnière, C, Thauvin, C, Frebourg, T, Lambert, J-C, and Campion, D
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- 2012
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30. Recruitment strategies for preventive trials. The MAPT study (Multidomain Alzheimer Preventive Trial)
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Carrie, I., Abellan Van Kan, G., Gillette-Guyonnet, S., Andrieu, S., Dartigues, J. -F., Touchon, J., Dantoine, T., Rouaud, O., Bonnefoy, M., Robert, P., Cuffi, M. -N., Bories, L., Bordes, S., Gasnier, Y., Desclaux, F., Sudres, K., Pesce, A., and Vellas, B.
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- 2012
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31. APOE and Alzheimer disease: a major gene with semi-dominant inheritance
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Genin, E, Hannequin, D, Wallon, D, Sleegers, K, Hiltunen, M, Combarros, O, Bullido, M J, Engelborghs, S, De Deyn, P, Berr, C, Pasquier, F, Dubois, B, Tognoni, G, Fiévet, N, Brouwers, N, Bettens, K, Arosio, B, Coto, E, Del Zompo, M, Mateo, I, Epelbaum, J, Frank-Garcia, A, Helisalmi, S, Porcellini, E, Pilotto, A, Forti, P, Ferri, R, Scarpini, E, Siciliano, G, Solfrizzi, V, Sorbi, S, Spalletta, G, Valdivieso, F, Vepsäläinen, S, Alvarez, V, Bosco, P, Mancuso, M, Panza, F, Nacmias, B, Bossù, P, Hanon, O, Piccardi, P, Annoni, G, Seripa, D, Galimberti, D, Licastro, F, Soininen, H, Dartigues, J-F, Kamboh, M I, Van Broeckhoven, C, Lambert, J C, Amouyel, P, and Campion, D
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- 2011
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32. Detection of moving foreground objects in videos with strong camera motion
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Szolgay, D., Benois-Pineau, J., Megret, R., Gaestel, Y., and Dartigues, J.-F.
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- 2011
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33. Diagnosis of Alzheimer’s disease patients with rapid cognitive decline in clinical practice: Interest of the Deco questionnaire
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Carcaillon, Laure, Berrutp, G., Sellalm, F., Dartigues, J. F., Gillette, S., Pere, J. J., and Bourdeix, I.
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- 2011
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34. IAGG Workshop: Identification of the main domains for quality of care and clinical research in nursing homes
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Rolland, Y., Aquino, J. -P., Andrieu, S., Beard, J., Benetos, A., Berrut, G., Coll-Planas, L., Dartigues, J. -F., Dong, B. R., Forette, F., Franco, A., Franzoni, S., Hornez, T., Metais, P., Ruault, G., Stephan, E., Swagerty, D., Tolson, D., Volicer, L., Vellas, B., and Morley, J.
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- 2011
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35. Nutrition and age-related eye diseases: The Alienor (Antioxydants, lipides essentiels, nutrition et maladies oculaires) study
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Delcourt, Cécile, Korobelnik, J. -F., Barberger-Gateau, P., Delyfer, M. -N., Rougier, M. -B., Le Goff, M., Malet, F., Colin, J., and Dartigues, J. -F.
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- 2010
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36. Dementia case management effectiveness on health care costs and resource utilization: a systematic review of randomized controlled trials
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Pimouguet, Clément, Lavaud, T., Dartigues, J. F., and Helmer, C.
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- 2010
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37. Polysomnographic data in patients with isolated memory complaints or mild cognitive impairment: P769
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Sagaspe, P., Taillard, J., Chaufton, C., Berthomier, C., Brandewinder, M., Amiéva, H., Dartigues, J.-F., and Philip, P.
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- 2014
38. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease
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Chapuis, J, Hot, D, Hansmannel, F, Kerdraon, O, Ferreira, S, Hubans, C, Maurage, C A, Huot, L, Bensemain, F, Laumet, G, Ayral, A M, Fievet, N, Hauw, J J, DeKosky, S T, Lemoine, Y, Iwatsubo, T, Wavrant-Devrièze, F, Dartigues, J F, Tzourio, C, Buée, L, Pasquier, F, Berr, C, Mann, D, Lendon, C, Alpérovitch, A, Kamboh, M I, Amouyel, P, and Lambert, J C
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- 2009
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39. Long-term correlates of future incident AD in prospective population cohorts according to education. Longitudinal neurocognitive data: OS1110
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Orgogozo, J.-M., Amieva, H., Jacqmin-Gadda, H., Stern, Y., and Dartigues, J.-F.
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- 2014
40. Mild Alzheimer’s disease: A «Position Paper»
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Delrieu, J., Voisin, T., Andrieu, S., Belliard, S., Belmin, J., Blanchard, F., Ceccaldi, M., Dartigues, J. F., Defontaines, B., Lehericy, S., Mekies, C., Moreaud, O., Naccache, L., Nourhashemi, F., Ousset, P. J., Pasquier, F., Payoux, P., Puisieux, F., Robert, P., Touchon, J., Vellas, B., and Dubois, B.
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- 2009
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41. Rapid cognitive decline in Alzheimer’s disease. Consensus paper
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Soto, M. E., Andrieu, S., Arbus, C., Ceccaldi, M., Couratier, P., Dantoine, T., Dartigues, J. -F., Gillette-guyonette, S., Nourhashemi, F., Ousset, P. -J., Poncet, M., Portet, F., Touchon, J., and Vellas, B.
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- 2008
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42. Prevention of progression to dementia in the elderly: Rationale and proposal for a health-promoting memory consultation (an IANA task force)
- Author
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Gillette-Guyonnet, S., Van Kan, G. Abellan, Andrieu, S., Aquino, J. P., Arbus, C., Becq, J. P., Berr, C., Bismuth, S., Chamontin, B., Dantoine, T., Dartigues, J. F., Dubois, B., Fraysse, B., Hergueta, T., Hanaire, H., Jeandel, C., Lagleyre, S., Lala, F., Nourhashemi, F., Ousset, P. J., Portet, F., Ritz, P., Robert, P., Rolland, Y., Sanz, C., Soto, M., Touchon, J., and Vellas, B.
- Published
- 2008
- Full Text
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43. 3rd IANA (International Academy on Nutrition and Aging) Meeting Nutrition, Exercise & Alzheimer and Clinical Trials on Sarcopenia August 1–2, 2008 Hyatt Regency Tamaya Resort 1300 Tuyuna Trail Santa Ana Pueblo, NM USA
- Author
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Andrieu, S., Barberger-Gateau, P., Raffaitin, C., Berr, C., Tzourio, C., Dartigues, J. -F., Gin, H., Fitten, L. J., Ortiz, F., Fairbanks, L., Bartzokis, G., Lu, P., Ringman, J., Heyn, P. C., Locher, J. L., Salvà, A., Andrieu, S., Fernández, E., Vellas, B., van de Rest, O., Geleijnse, J. M., Kok, F. J., van Staveren, W. A., Beekman, A. T. F., Hoefnagels, W. H. L., de Groot, C. P. G. M., Angevaren, M., Aufdemkampe, G., Verhaar, H. J. J., Aleman, A., Vannees, L., Arkin, S., Florez, H., Gerstein, H., Sheridan, P., Bosch, J., Goldberg, R., Kaspar, K. M., Drawert, S. M., Marcus, R. L., Kidde, J., Dibble, L., Addison, O., LaStayo, P. C., Scarmeas, N., Stern, Y., Schupf, N., Luchsinger, J. A., Sharkey, J. R., Laditka, J. N., Laditka, S. B., Liu, R., Hochhalter, A., Robare, J. F., Türner, N., Judge, M., Foster, T. C., Erdos, B., Cudykier, I., Scarpace, P. J., Weiss, L. A., Bergstrom, J., Kritz-Silverstein, D., Barrett-Connor, Elizabeth, Yurko-Mauro, K., Nelson, E., Quinn, J., Sattler, F. R., Castaneda-Sceppa, C., Binder, E. F., Schroeder, E. T., Wang, Y., Bhasin, S., Kawakubo, M., Stewart, Y., Hahn, C., Colletti, P., Roubenoff, R., Yarasheski, K. E., Azen, S. P., Aoki, Y., Yamamoto, T., Otuka, T., Blanc-Bisson, C., Bourdel-Marchasson, I., Bocock, M. A., Keller, H. H., Bowman, G., Baxter, J., Oken, B., Frei, B., Traber, M., Leonard, S., Kaye, J., Shannon, J., Quinn, J., Carlsson, M., Gustafson, Y., Eriksson, S., Littbrand, H., Håglin, L., Danthiir, V., Wilson, C., Nettelbeck, T., Burns, N., Wittert, G., Noakes, M., Clifton, P., DiMaria-Ghalili, R. A., Grieger, J. A., Nowson, C. A., Wattanapenpaiboon, N. T., Holstein, J., Robinson, C., Hartmann, C., Rueb, S., Heffel, L., Dintaman, S., Reynolds, J., Fleming, L., Crull, M., Goldey, J., Serper, L. L., Hubbard, R., Westengard, J., Horning, M., Ishige, Y., Aoki, Y., Keller, H. H., Keller, H. H., LaStayo, P. C., Marcus, R. L., Smith, S., Kidde, J., Dibble, L., Butler, C., Hill, M., LaStayo, P. C., Marcus, R. L., Dibble, L., Kidde, J., Peters, C., Meier, W., Laughlin, G. A., Kritz-Silverstein, D., von Muhlen, D., Barrett-Connor, E., Olariu, L., Petcu, M., Tulcan, C., Pup, M., Otilingam, P., Gate, M., Pasinetti, G. M., Ray, B., Chauhan, N. B., Bailey, J. A., Lahiri, D. K., Shatenstein, B., Kergoat, M. -J., Reid, I., Chicoine, M. -E., Vaz, L., Stewart, R., Sabbah, W., Tsakos, G., D’Aiuto, F., Watt, R. G., Sturman, M., Kelly, J., Fleischman, D., Leurgans, S., Bennett, D., Morris, M. C., Suominen, M. H., Muurinen, S., Soini, H., Pitkälä, K. H., Yamamoto, T., Fujinoki, C., and Aoki, Y.
- Published
- 2008
- Full Text
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44. Risk profiles for mild cognitive impairment and progression to dementia are gender specific
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Artero, S., Ancelin, M.-L., Portet, F., Dupuy, A., Berr, C., Dartigues, J.-F., Tzourio, C., Rouaud, O., Poncet, M., Pasquier, F., Auriacombe, S., Touchon, J., and Ritchie, K.
- Subjects
Dementia -- Development and progression ,Dementia -- Demographic aspects ,Cognition disorders -- Risk factors ,Cognition disorders -- Demographic aspects ,Parasympatholytic agents -- Usage ,Health ,Psychology and mental health - Published
- 2008
45. Characteristics of undiagnosed diabetes in community-dwelling French elderly: The 3C study
- Author
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Bourdel-Marchasson, I., Helmer, C., Barberger-Gateau, P., Peuchant, E., Février, B., Ritchie, K., and Dartigues, J.-F.
- Published
- 2007
- Full Text
- View/download PDF
46. Association between antioxidant nutritional indicators and the incidence of dementia: results from the PAQUID prospective cohort study
- Author
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Helmer, C, Peuchant, E, Letenneur, L, Bourdel-Marchasson, I, Larrieu, S, Dartigues, J F, Dubourg, L, Thomas, M-J, and Barberger-Gateau, P
- Published
- 2003
- Full Text
- View/download PDF
47. Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology
- Author
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Chapuis, J, Hansmannel, F, Gistelinck, M, Mounier, A, Van Cauwenberghe, C, Kolen, K V, Geller, F, Sottejeau, Y, Harold, D, Dourlen, P, Grenier-Boley, B, Kamatani, Y, Delepine, B, Demiautte, F, Zelenika, D, Zommer, N, Hamdane, M, Bellenguez, C, Dartigues, J-F, Hauw, J-J, Letronne, F, Ayral, A-M, Sleegers, K, Schellens, A, Broeck, L V, Engelborghs, S, De Deyn, P P, Vandenberghe, R, OʼDonovan, M, Owen, M, Epelbaum, J, Mercken, M, Karran, E, Bantscheff, M, Drewes, G, Joberty, G, Campion, D, Octave, J-N, Berr, C, Lathrop, M, Callaerts, P, Mann, D, Williams, J, Buée, L, Dewachter, I, Van Broeckhoven, C, Amouyel, P, Moechars, D, Dermaut, B, and Lambert, J-C
- Published
- 2013
- Full Text
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48. Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimerʼs disease
- Author
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Lambert, J-C, Grenier-Boley, B, Harold, D, Zelenika, D, Chouraki, V, Kamatani, Y, Sleegers, K, Ikram, M A, Hiltunen, M, Reitz, C, Mateo, I, Feulner, T, Bullido, M, Galimberti, D, Concari, L, Alvarez, V, Sims, R, Gerrish, A, Chapman, J, Deniz-Naranjo, C, Solfrizzi, V, Sorbi, S, Arosio, B, Spalletta, G, Siciliano, G, Epelbaum, J, Hannequin, D, Dartigues, J-F, Tzourio, C, Berr, C, Schrijvers, E MC, Rogers, R, Tosto, G, Pasquier, F, Bettens, K, Van Cauwenberghe, C, Fratiglioni, L, Graff, C, Delepine, M, Ferri, R, Reynolds, C A, Lannfelt, L, Ingelsson, M, Prince, J A, Chillotti, C, Pilotto, A, Seripa, D, Boland, A, Mancuso, M, Bossù, P, Annoni, G, Nacmias, B, Bosco, P, Panza, F, Sanchez-Garcia, F, Del Zompo, M, Coto, E, Owen, M, OʼDonovan, M, Valdivieso, F, Caffara, P, Scarpini, E, Combarros, O, Buée, L, Campion, D, Soininen, H, Breteler, M, Riemenschneider, M, Van Broeckhoven, C, Alpérovitch, A, Lathrop, M, Trégouët, D-A, Williams, J, Amouyel, P, consortium, E ADI, and consortium, G ERAD
- Published
- 2013
- Full Text
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49. Detection of depressive symptomatology in elderly people: A short version of the CES-D scale
- Author
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Rouch-Leroyer, I., Sourgen, C., Barberger-Gateau, P., Fuhrer, R., and Dartigues, J. F.
- Published
- 2000
- Full Text
- View/download PDF
50. Intake of flavonoids and risk of dementia
- Author
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Commenges, D., Scotet, V., Renaud, S., Jacqmin-Gadda, H., Barberger-Gateau, P., and Dartigues, J.-F.
- Published
- 2000
- Full Text
- View/download PDF
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