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1. Students Encouraging Other Students' Learning: Leadership Shared Metacognition in Practice

Author: Sharrell Hassell-Goodman, Aoi Yamanaka, Janet Athanasiou, and Jan Arminio
Abstract: This article discusses the conceptual bridges between the leadership learning framework; specifically, its emphasis on metacognition and social justice advocacy, and explores how leadership education might be revamped. The focus of the article is practicing socially shared metacognition using the American Counseling Association's (ACA) advocacy competencies model. The purpose of the ACA advocacy model is to offer comprehensive advocacy--at individual, group, and community dimensions--with interventions aimed at systematic change. The model stresses creating alliances and working with the community. The article concludes with the practical implications of applying metacognition in leadership education and additional resources. A case example (Kai) is used throughout this article.
Published: 2024
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2. Evolution of Self-reported Neuropsychiatric Symptoms After Switching from Dolutegravir/Abacavir/Lamivudine to Bictegravir/Emtricitabine/Tenofovir Alafenamide: Results from the Randomized DOBINeuro Trial

Author: Rossetti, Barbara, Ferrara, Micol, Taramasso, Lucia, Bai, Francesca, Lombardi, Francesca, Ciccarelli, Nicoletta, Durante, Miriam, Alladio, Francesca, Bonazza, Federica, Rancan, Ilaria, Montagnani, Francesca, Di Biagio, Antonio, Monforte, Antonella d’Arminio, Zazzi, Maurizio, and Fabbiani, Massimiliano
Published: 2024
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3. Committing to Intentional Practice: Using the Practitioner Scholarship of Adam Peck to Demonstrate an Innovative Path for Campus Activities

Author: Arminio, Jan and Preston, Michael
Abstract: At the time of his death, Dr. Adam Peck served as Assistant Vice President for Student Affairs at Illinois State University. During his 25 years in student affairs, he served in a variety of other roles, including assistant vice president and dean of students at Stephen F. Austin State University and director of student life at Saint Louis University. Adam was unique in that he was a student affairs professional who met the criteria of being a practitioner-scholar, an administrator in which research, contributing to it and consuming it, plays a significant role. Dr. Peck not only wanted to engage in scholarly pursuits, he needed to because he believed writing clarified his thinking about complex issues and guided his practice. On the morning of September 30th, 2022, Adam died from injuries sustained in a pedestrian accident. He was 49 years old. His name may not be well recognized in higher education, but he was not one for fanfare or the spotlight. Yet, he did his best to help students succeed. As highlighted in this article, to those who knew Dr. Peck, he was a storyteller. He told and enacted stories of caring, curiosity, compassion, scholarship, and intellectualism -- a life lived well. This article is his story as well as the story of how the campus activities profession must continue his work.
Published: 2023

4. Clinical Outcome and 7-Day Virological Clearance in High-Risk Patients with Mild–Moderate COVID-19 Treated with Molnupiravir, Nirmatrelvir/Ritonavir, or Remdesivir

Author: Bai, Francesca, Beringheli, Tomaso, Vitaletti, Virginia, Santoro, Andrea, Molà, Francesco, Copes, Alessandro, Gemignani, Nicole, Pettenuzzo, Sofia, Castoldi, Roberto, Varisco, Benedetta, Nardo, Riccardo, Lundgren, Lorenzo Brando, Ligresti, Riccardo, Sala, Matteo, Albertini, Lorenzo, Augello, Matteo, Biasioli, Lorenzo, Bono, Valeria, Rovito, Roberta, Bini, Teresa, Passarella, Sabrina, Orfeo, Nicola Vincenzo, Monforte, Antonella d’Arminio, and Marchetti, Giulia
Published: 2024
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5. Do we Still Need Eligibility Criteria to Recommend PrEP? Impact of National Prescribing Requirements on Retention in Care and Sexually Transmitted Infections Acquisition

Author: Rossotti, Roberto, Tavelli, Alessandro, Calzavara, Daniele, De Bona, Anna, Muccini, Camilla, Moschese, Davide, Caruso, Enrico, Soria, Alessandro, Bossolasco, Simona, Lapadula, Giuseppe, Cernuschi, Massimo, and Monforte, Antonella d’Arminio
Published: 2024
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6. The Important Role of Distortion Recognition in Student Advocacy Leadership Development

Author: Aoi Yamanaka, Sharrell Hassell-Goodman, Janet Athanasiou, and Jan Arminio
Abstract: Though promoting student advocacy has become an essential part of leadership education, few studies explore development of advocacy in leadership education. This article offers how distortions, an aspect of a Black feminist reframing of dissonance, is related to existing leadership education literature. It then introduces students' voices demonstrating the importance of the realization of distortions in student advocacy development and links distortions with how power communicates and upholds systemic oppression. Finally, we offer practical recommendations based on a case scenario that utilize Black feminist perspectives of dissonance in refining student advocacy leadership education. Such insight prompts more effective strategies in student advocate development.
Published: 2024
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7. The Need for More Alliances in Advocating for, with, and to Others in Higher Education

Author: Jan Arminio, Aoi Yamanaka, Sharrell Hassell-Goodman, Janet Athanasiou, and Richard M. Hess
Abstract: Though advocacy and activism have been frequent topics of research, few studies explore this work across campus roles, meaning inclusive of students, faculty, and staff. A more holistic understanding of advocacy would pave the way for more effective social justice efforts. Researchers used hermeneutic phenomenology to engage with 26 advocates finding that identity influences advocacy; advocates work for, with, and to others; and advocates take risks with consequences associated with their identities. The American Counseling Association's Advocacy Competencies extended the analysis to reveal the lack of alliances in cross-campus advocacy.
Published: 2024
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8. Kinetics of hepatitis B virus replication in anti-HBc positive/HBsAg-negative people with HIV switching to tenofovir sparing therapy

Author: Romina Salpini, Stefano D'Anna, Mohammad Alkhatib, Lorenzo Piermatteo, Alessandro Tavelli, Livia Benedetti, Eugenia Quiros Roldan, Antonella Cingolani, Chiara Papalini, Stefania Carrara, Vincenzo Malagnino, Massimo Puoti, Loredana Sarmati, Francesca Ceccherini-Silberstein, Carlo Federico Perno, Antonella d'Arminio Monforte, and Valentina Svicher
Subjects: HBV/HIV co-infection, TDF/TAF, Ultrasensitive HBV-DNA, HBV-RNA, Infectious and parasitic diseases, RC109-216
Abstract: Objectives: To unravel the still unexplored HBV-replicative kinetics in anti-HBc-positive/HBsAg-negative people-with-HIV (PWH) suspending tenofovir disoproxil-fumarate/tenofovir-alafenamide (TDF/TAF). Methods: A total of 101 anti-HBc-positive/HBsAg-negative PWH switching to TDF/TAF-sparing therapy were included. Serum HBV-DNA and HBV-RNA were quantified by droplet-digital-PCR at switching (T0), within 12 months (T1) and 12-24 months postswitch (T2). Results: At T0, 33.7% had cryptic HBV-DNA (undetected by commercial assays, median [interquartile range (IQR)]: 2 [1-5] IU/mL) and 22% were positive to HBV-RNA alone (median [IQR]: 4 [3-4] IU/mL), indicating an active HBV-reservoir despite HBsAg-negativity and TDF/TAF-pressure. Notably, anti-HBs-titer 10 IU/mL increased from 12.9% at T1 to 42.6% at T2 (P < 0.0001). Likewise, a rise from 2 to 11% was observed for HBV-DNA >100 IU/mL (P = 0.02); median (IQR) HBV-DNA: 579 (425-770) IU/mL. Notably, HBV-DNA >10 IU/mL at T2 occurred in 70% of PWH with cryptic HBV-DNA, in 38.5% with HBV-RNA alone and in 25% negative to both HBV-markers at T0 (P = 0.01). Cryptic HBV-DNA at T0 and lower nadir CD4+ T-cell-count independently predicted HBV-DNA >10 IU/mL at T2 (OR [95% CI]: 8.2 [1.7-40.6], P = 0.01; OR [95% CI]: 8.1 [1.3-52.1], P = 0.03). Lastly, persistent HBV-DNA positivity was independently associated with a reduced CD4+ T-cell recovery at T2 (OR [95% CI]: 0.07 [0.01-0.77], P = 0.03). Conclusion: This study underlines the importance to regularly monitor anti-HBc-positive/HBsAg-negative PWH undergoing TDF/TAF-sparing regimen and the role of highly-sensitive HBV markers in optimizing their management.
Published: 2025
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9. Clinical and laboratory predictors of mpox severity and duration: an Italian multicentre cohort study (mpox-Icona)

Author: Antinori, Andrea, Antinori, Spinello, Baiguera, Chiara, Baldin, Gianmaria, Bassetti, Matteo, Biasioli, Lorenzo, Bonfanti, Paolo, Brucci, Giorgia, Bruzzesi, Elena, Candela, Caterina, Cascio, Antonio, Castagna, Antonella, Monforte, Antonella d'Arminio, Delama, Andrea, D'Ettorre, Gabriella, Farinacci, Damiano, Fusco, Francesco Maria, Gismondo, Maria Rita, Gori, Andrea, Lanini, Simone, Lanzafame, Massimiliano, Lapadula, Giuseppe, Lichtner, Miriam, Maci, Chiara, Mancarella, Giulia, Mancon, Alessandro, Marchetti, Giulia, Matusali, Giulia, Mazzotta, Valentina, Nicastri, Emanuele, Nozza, Silvia, Pandolfo, Alessandro, Panzo, Francesca, Piconi, Stefania, Pinnetti, Carmela, Pipitò, Luca, Raccagni, Angelo Roberto, Raimondi, Alessandro, Ridolfi, Marco, Rizzardini, Giuliano, Rodanò, Alessandra, Rossotti, Roberto, Sambo, Margherita, Sangiovanni, Vincenzo, Sangiovanni, Nadia, Tamburrini, Enrica, Tavelli, Alessandro, Tesoro, Daniele, Vita, Serena, Moschese, Davide, Mileto, Davide, Di Biagio, Antonio, and Monforte, Antonella d’Arminio
Published: 2024
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10. Monoclonal antibodies against SARS-CoV-2 to prevent COVID-19 worsening in a large multicenter cohort

Author: Alessandro Soria, Francesca Graziano, Giulia Ghilardi, Giuseppe Lapadula, Daniela Dalla Gasperina, Simone Vasilij Benatti, Eugenia Quiros-Roldan, Maurizio Milesi, Francesca Bai, Marco Merli, Davide Minisci, Marco Franzetti, Erika Asperges, Filippo Chiabrando, Daria Pocaterra, Alessandro Pandolfo, Fabio Zanini, Domenico Lombardi, Anna Cappelletti, Alban Rugova, Maria Lucia Borghesi, Nicola Squillace, Luigi Pusterla, Stefania Piconi, Paola Morelli, Patrizia Rovere Querini, Raffaele Bruno, Stefano Rusconi, Salvatore Casari, Alessandra Bandera, Fabio Franzetti, Giovanna Travi, Antonella D'Arminio Monforte, Giulia Marchetti, Angelo Pan, Francesco Castelli, Marco Rizzi, Francesco Dentali, Maria Mallardo, Emanuela Rossi, Maria Grazia Valsecchi, Stefania Galimberti, and Paolo Bonfanti
Subjects: Monoclonal antibodies, COVID-19, SARS-CoV-2, Hospitalization, Immunodeficiency, Omicron variant, Science (General), Q1-390, Social sciences (General), H1-99
Abstract: Objective: Monoclonal antibodies (mAbs) against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) reduced Coronavirus Disease 2019 (COVID-19) hospitalizations in people at risk of clinical worsening. Real-world descriptions are limited. Methods: CONDIVIDIAMO, a two-year multicenter observational study, consecutively enrolled SARS-CoV-2 outpatients with ≥1 risk factor for COVID-19 progression receiving mAbs. Demographic data, underlying medical condition, type of mAbs combination received, duration of symptoms before mAbs administration, COVID-19 vaccination history, were collected upon enrolment and centrally recorded. Data on outcomes (hospitalizations, reasons of hospitalization, deaths) were prospectively collected. The primary endpoint was the rate of hospitalization or death in a 28-day follow-up, whichever occurred first; subjects were censored at the day of last follow-up or up to 28 days. The Kaplan-Meier method was used to estimate the incidence rate curve in time. The Cox regression model was used to assess potential risk factors for unfavorable outcome. Results were shown as hazard ratio (HR) along with the corresponding 95 % Confidence Interval (95%CI). Results: Among 1534 subjects (median [interquartile range, IQR] age 66.5 [52.4–74.9] years, 693 [45.2 %] women), 632 (41.2 %) received bamlanivimab ± etesevimab, 209 (13.6 %) casirivimab/imdevimab, 586 (38.2 %) sotrovimab, 107 (7.0 %) tixagevimab/cilgavimab. After 28-day follow-up, 87/1534 (5.6 %, 95%CI: 4.4%–6.8 %) met the primary outcome (85 hospitalizations, 2 deaths). Hospitalizations for COVID-19 (52, 3.4 %) occurred earlier than for other reasons (33, 2.1 %), after a median (IQR) of 3.5 (1–7) versus 8 (3–15) days (p = 0.006) from mAbs administration.In a multivariable Cox regression model, factors independently associated with increased hospitalization risk were age (hazard ratio [HR] 1.02, 95%CI 1.00–1.03, p = 0.021), immunodeficiency (HR 1.78, 95%CI 1.11–2.85, p = 0.017), pre-Omicron calendar period (HR 1.66, 95%CI 1.02–2.69, p = 0.041). Conclusions: MAbs real-world data over a 2-year changing pandemic landscape showed the feasibility of the intervention, although the hospitalization rate was not negligible. Immunosuppressed subjects remain more at risk of clinical worsening.
Published: 2024
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11. Theoretical study based on molecular docking to investigate the potential interaction of known antiviral food components with SARS-CoV-2 proteins

Author: Giordano, Deborah, Argenio, Maria Antonia, Scafuri, Bernardina, Carbone, Virginia, Bonora, Simone, D'Arminio, Nancy, Marabotti, Anna, and Facchiano, Angelo
Published: 2024
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12. Problemas do controle monetário no Brasil

Author: ARMINIO FRAGA NETO
Subjects: Política monetária, inflação, estabilização, Economics as a science, HB71-74
Abstract: RESUMO O controle dos agregados monetários no Brasil enfrenta três grandes problemas: 1) alto déficit orçamentário do governo; 2) a ineficácia da taxa de juros como instrumento de política em um ambiente de alta inflação; 3) inovação financeira imprevisível. Os dois primeiros problemas são especialmente importantes quando se tenta projetar programas de estabilização. Depois que a inflação atinge um certo nível, as políticas monetárias padrão tornam-se impotentes. O controle do déficit orçamentário (ou seja, a limitação do uso do imposto inflacionário) torna-se uma condição necessária para a estabilização.
Published: 2024
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13. Impact of COVID Pandemic on Sexual Habits and Pre-exposure Prophylaxis Retention in Care in a Community-Based Service

Author: Rossotti, Roberto, Tavelli, Alessandro, Calzavara, Daniele, De Bona, Anna, Vinti, Pietro, Muccini, Camilla, Tesoro, Daniele, Bossolasco, Simona, Cernuschi, Massimo, and Monforte, Antonella d’Arminio
Published: 2023
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14. Technical Report on the New Ultrasound Lateral Mid-Shaft Approach to the Sciatic Nerve: A Never-Ending Story

Author: Giuseppe Sepolvere, Mario Tedesco, Mario Cibelli, Dario Cirillo, Angelo Sparaco, Giuseppe Gagliardi, Giuseppina Costagliola, Loredana Cristiano, Valeria Rita Scialdone, Maria Rosaria Pasquariello, Fabrizio Di Zazzo, Luigi Merola, Mirco Della Valle, Daniela Arminio, Leonardo Maria Bottazzo, Marco Folliero, Giorgio Ranieri, Domenico Pietro Santonastaso, and Antonio Coviello
Subjects: loco-regional anesthesia, nerve block, sciatic nerve, lower limb, Medicine (General), R5-920
Abstract: The anatomy of the sciatic nerve allows it to be blocked at different levels using various anesthetic approaches. However, for several reasons, performing these approaches may be challenging or disadvantageous in specific categories of patients, particularly in obese patients. The objective of this brief technical report is to describe a new technical approach to sciatic nerve block, designed to simplify the procedure for certain categories of patients and less experienced practitioners. Since 2010, more than 5000 procedures have been performed by both experienced anesthesiologists and novice trainees in several hospitals. The ultrasound lateral mid-shaft technique appears to be a safe and effective method for performing a sciatic nerve block, even in obese patients with significant subcutaneous fat and unclear ultrasound images. This approach is particularly beneficial given the various anatomical variations that can occur. By targeting the mid-thigh area, the ultrasound beam accesses anatomical structures that are more superficial, improving the technique’s efficacy. Various hospital groups have been performing this technique as a routine procedure, achieving a success rate of nearly 100%. This impressive success rate exceeds that of other conventional techniques documented in the literature. Additionally, there have been significant improvements in comfort and ease for anesthetists. This method allows the anesthetic to spread around the paraneural sheath, covering the posterior femoral cutaneous nerve. Finally, it is performed in the supine position without the need to mobilize the lower limbs, ensuring patient comfort, especially in cases of fractures or lower limb injuries. Further studies are needed to confirm these results.
Published: 2025
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15. Probability of Starting Two-Drug Regimen (2DR) vs. Three-Drug Regimen (3DR) in ART-Naïve and ART-Experienced Person with HIV (PWH) Across the First Wave of COVID-19 Pandemic

Author: Alessandra Vergori, Nicola Gianotti, Alessandro Tavelli, Camilla Tincati, Andrea Giacomelli, Elena Matteini, Giuseppe Lapadula, Lucia Taramasso, Loredana Sarmati, Antonella D’Arminio Monforte, Andrea Antinori, Alessandro Cozzi-Lepri, and on behalf of the ICONA Foundation Study
Subjects: HIV, COVID-19 lockdown, 2DR, 3DR, Microbiology, QR1-502
Abstract: Background: This study examined the impact of the COVID-19 lockdown on antiretroviral therapy (ART) prescriptions among persons living with HIV (PWH) in Italy. Methods: Data from the ICONA cohort included ART-naïve individuals who started ART between January 2019 and December 2022, and ART-experienced individuals who started new ART with HIV RNA ≤50 cps/mL from January 2016 to December 2022. The analysis focused on the proportion of PWH starting or switching to dual (2DR) versus triple (3DR) ART regimens. Comparisons were made using Chi-square and Kruskal-Wallis tests, with logistic regression (LR) to assess associations, adjusting for sex and age. Results: Among 2481 ART-naïve PWH, 17% were female, with a median age of 40. Using 2020 as the comparator (the lockdown year), the odds ratio (OR) from fitting a LR showed a reduced probability of prescribing 2DR both before and after 2020. The proportion of PWH starting 2DR was 9% in 2019, 18% in 2020, 13% in 2021, and 10% in 2022. Among 12,335 ART-experienced PWH, 20% were female, with a median age of 47. The proportion switching to 2DR rose from 24% in 2016 to 38% in 2020, 62% in 2021, and 65% in 2022, showing a >3-fold higher probability to be switched to 2DR instead of 3DR in recent years (2021-2022). Conclusions: For ART-naive PWH, 2DR initiation did not decrease during the 2020 lockdown but changed in the following years, possibly indicating shifts in clinical practice or resuming HIV services. For ART-experienced PWH, 2DR prescriptions increased significantly over time, especially for INSTI-based regimens.
Published: 2024
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16. SARS-CoV-2 mRNA vaccination and short-term changes in viral load and CD4/CD8 T-cell counts in people living with HIV

Author: Alessandra Vergori, Alessandro Cozzi-Lepri, Alessandro Tavelli, Valentina Mazzotta, Anna Maria Azzini, Roberta Gagliardini, Ilaria Mastrorosa, Alessandra Latini, Giovanni Pellicanò, Lucia Taramasso, Francesca Ceccherini-Silberstein, Maddalena Giannella, Evelina Tacconelli, Giulia Marchetti, Antonella d'Arminio Monforte, and Andrea Antinori
Subjects: HIV, mRNA SARS-CoV-2 vaccine, CD4 count, CD8 count, HIV RNA, Viro-immunological changes, Infectious and parasitic diseases, RC109-216
Abstract: Objectives: To investigate whether SARS-CoV-2 messenger RNA (mRNA) vaccination has an impact on HIV-related viro-immunological parameters. Methods: People with HIV (PWH) in the VAXICONA-ORCHESTRA cohort who received one or more doses of SARS-CoV-2 mRNA vaccine and for whom paired measures of immuno-virological markers (viral load, clusters of differentiation [CD]4, and CD8 count 1 month before and after a vaccine dose [VD]) were available were included. Paired t-test and generalized estimating equation linear regression analyses were used to study changes over ± 1 month around the VD. Subgroup analyses were performed. Results: A total of 510 PWH were enrolled: the median age was 55 years (interquartile range 46-60 years), the CD4 and CD8 count were 489 (287-719) and 790 (59-1104) cells/mm3, respectively, and 81% received three VDs. After a median of 28 (3-53) days from VD, CD4 count increased by +15 cells/mm3 (SD ± 129.7, P = 0.001) and CD8 by +12 (±250.5, P = 0.199) and the viral load decreased by −0.11 log10 (±0.88, P = 0.001). Similar results were observed after restricting the analysis to viro-suppressed PWH, with CD4 ≤200/mm3, more than 6 months of antiretroviral therapy before VD and after excluding previous COVID-19. Conclusions: A small significant increase in CD4 count and a negligible drop in HIV RNA were observed. Our findings are consistent with the hypothesis that SARS-CoV-2 mRNA vaccine can prime CD4 T spike-specific cells, even in the more immuno-compromised PWH.
Published: 2024
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17. Fluid-structure interaction simulation of mechanical aortic valves: a narrative review exploring its role in total product life cycle

Author: Mariachiara Arminio, Dario Carbonaro, Umberto Morbiducci, Diego Gallo, and Claudio Chiastra
Subjects: heart valve prosthesis, mechanical aortic valve, valve fluid dynamics, in silico medicine, computer modelling, fluid-structure interaction simulation, Medical technology, R855-855.5
Abstract: Over the last years computer modelling and simulation has emerged as an effective tool to support the total product life cycle of cardiovascular devices, particularly in the device preclinical evaluation and post-market assessment. Computational modelling is particularly relevant for heart valve prostheses, which require an extensive assessment of their hydrodynamic performance and of risks of hemolysis and thromboembolic complications associated with mechanically-induced blood damage. These biomechanical aspects are typically evaluated through a fluid-structure interaction (FSI) approach, which enables valve fluid dynamics evaluation accounting for leaflets movement. In this context, the present narrative review focuses on the computational modelling of bileaflet mechanical aortic valves through FSI approach, aiming to foster and guide the use of simulations in device total product life cycle. The state of the art of FSI simulation of heart valve prostheses is reviewed to highlight the variety of modelling strategies adopted in the literature. Furthermore, the integration of FSI simulations in the total product life cycle of bileaflet aortic valves is discussed, with particular emphasis on the role of simulations in complementing and potentially replacing the experimental tests suggested by international standards. Simulations credibility assessment is also discussed in the light of recently published guidelines, thus paving the way for a broader inclusion of in silico evidence in regulatory submissions. The present narrative review highlights that FSI simulations can be successfully framed within the total product life cycle of bileaflet mechanical aortic valves, emphasizing that credible in silico models evaluating the performance of implantable devices can (at least) partially replace preclinical in vitro experimentation and support post-market biomechanical evaluation, leading to a reduction in both time and cost required for device development.
Published: 2024
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18. Heavily treatment-experienced persons living with HIV currently in care in Italy: characteristics, risk factors, and therapeutic options—the ICONA Foundation cohort study

Author: Sergio Lo Caputo, Mariacristina Poliseno, Alessandro Tavelli, Roberta Gagliardini, Stefano Rusconi, Giuseppe Lapadula, Andrea Antinori, Daniela Francisci, Loredana Sarmati, Andrea Gori, Vincenzo Spagnuolo, Francesca Ceccherini-Silberstein, Antonella d'Arminio Monforte, and Alessandro Cozzi-Lepri
Subjects: Heavily treatment-experienced, HIV, Antiretroviral treatment, Immune-virological failure, Resistance mutations, Infectious and parasitic diseases, RC109-216
Abstract: Objectives: Heavily treatment-experienced (HTE) people living with HIV (PLWH) pose unique challenges due to limited antiretroviral treatment (ART) options. Our study aimed to investigate the prevalence and features of HTE individuals followed up in the Italian Cohort Naïve Antiretrovirals (ICONA) cohort as of December 31, 2021. Methods: HTE were defined based on meeting specific conditions concerning their current ART and their ART history up to December 31, 2021. Descriptive statistics were performed by HTE status. Regression analyses explored factors associated with becoming HTE based on pre-ART patients' characteristics. Cluster dendrogram analysis provided insights into subgroups with inadequate responses based on clusters of differentiation (CD4) counts and viral load (VL) trajectories. Results: Among the 8758 PLWH actively followed in our cohort, 163 individuals (1.9%), mainly female, younger, Italian, and infected through heterosexual contact, met the HTE criteria. A lower CD4 count at ART initiation (odds ratio [OR] 1.60 per 100 cells/mmc lower CD4, 95% confidence interval [CI] 1.06-2.41, P = 0.03) and hepatitis C virus antibody positivity (OR 1.90, 95% CI 1.16-3.11, P = 0.01) were associated with higher HTE risk. Thirty PLWH exhibited ongoing immune-virological failure (18% of the HTE subgroup and 0.003% of the total population). Thirty PLWH exhibited ongoing immune-virological failure (i.e., with a current CD4 count 200 copies/mL). A cluster analysis identified 13 (43%) with a current CD4 count
Published: 2024
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19. Persistent poor clinical outcomes of people living with HIV presenting with AIDS and late HIV diagnosis – results from the ICONA cohort in Italy, 2009-2022

Author: Annalisa Mondi, Alessandro Cozzi-Lepri, Alessandro Tavelli, Antonella Cingolani, Andrea Giacomelli, Giancarlo Orofino, Gabriella De Girolamo, Carmela Pinnetti, Andrea Gori, Annalisa Saracino, Alessandra Bandera, Giulia Marchetti, Enrico Girardi, Cristina Mussini, Antonella d'Arminio Monforte, and Andrea Antinori
Subjects: Late presenters, AIDS, Mortality, HIV, Immune recovery, Infectious and parasitic diseases, RC109-216
Abstract: Objectives: Limited data are available on the long-term outcomes in recent years for late HIV diagnosis (LD). Methods: All subjects with HIV enrolled in the ICONA cohort in 2009-2022 who started antiretroviral treatment (ART) within 4 months from diagnosis were included and divided into: (i) pre-ART CD4 count ≥350/mm3 without AIDS (non-LD), (ii) pre-ART CD4 count
Published: 2024
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20. Dynamics of viral DNA shedding and culture viral DNA positivity in different clinical samples collected during the 2022 mpox outbreak in Lombardy, Italy

Author: Antonio Piralla, Davide Mileto, Alberto Rizzo, Guglielmo Ferrari, Federica Giardina, Stefano Gaiarsa, Greta Petazzoni, Micol Bianchi, Federica Salari, Fiorenza Bracchitta, Josè Camilla Sammartino, Alessandro Ferrari, Gloria Gagliardi, Alessandro Mancon, Claudio Fenizia, Mara Biasin, Francesca Rovida, Stefania Paolucci, Elena Percivalle, Alessandra Lombardi, Valeria Micheli, Silvia Nozza, Antonella Castagna, Davide Moschese, Spinello Antinori, Andrea Gori, Paolo Bonfanti, Roberto Rossotti, Antonella D'Arminio Monforte, Federica Attanasi, Marcello Tirani, Danilo Cereda, Fausto Baldanti, Maria Rita Gismondo, Miriam Cutrera, Marianna Cuomo, Federica De Poli, Giulia Campanini, Antonino Maria Guglielmo Pitrolo, Elizabeth Iskandar, Irene Cassaniti, Raffaele Bruno, Giuliano Rizzardini, Massimo Puoti, Francesco Castelli, Laura Corsico, Andrea Giacomelli, Giacomo Pozza, Giacomo Casalini, Angelo Raccagni, Bendetta Trentacapilli, Costanza Bertoni, Elena Bruzzesi, Caterina Candela, Daniele Tesoro, Giovanni Mule, Alessandra Bandera, Antonio Muscatello Bianca Mariani, Manuel Maffeo, Riccardo Vecchio, and Sara Piccinelli
Subjects: Mpox virus, Molecular epidemiology, Next generation sequencing, Re-Emerging virus, Multiple samples, Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216
Abstract: Background: Mpox virus (MPXV) has recently spread outside of sub-Saharan Africa. This large multicentre study was conducted in Lombardy, the most densely populated Italian region accounting for more than 40% of Italian cases. The present study aims to: i) evaluate the presence and the shedding duration of MPXV DNA in different body compartments correlating the MPXV viability with the time to onset of symptoms; ii) provide evidence of MPXV persistence in different body compartment as a source of infection and iii) characterize the MPXV evolution by whole genome sequencing (WGS) during the outbreak occurred in Italy. Material and methods: The study included 353 patients with a laboratory-confirmed diagnosis of MPXV infection screened in several clinical specimens in the period May 24th - September 1st, 2022. Viral isolation was attempted from different biological matrices and complete genome sequencing was performed for 61 MPXV strains. Results: MPXV DNA detection was more frequent in the skin (94.4%) with the longest median time of viral clearance (16 days). The actively-replicating virus in cell culture was obtained for 123/377 (32.6%) samples with a significant higher viral quantity on isolation positive samples (20 vs 31, p
Published: 2024
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21. Host genetics and COVID-19 severity: increasing the accuracy of latest severity scores by Boolean quantum features

Author: Gabriele Martelloni, Alessio Turchi, Chiara Fallerini, Andrea Degl’Innocenti, Margherita Baldassarri, Simona Olmi, Simone Furini, Alessandra Renieri, GEN-COVID Multicenter study, Francesca Mari, Sergio Daga, Ilaria Meloni, Mirella Bruttini, Susanna Croci, Mirjam Lista, Debora Maffeo, Elena Pasquinelli, Giulia Brunelli, Kristina Zguro, Viola Bianca Serio, Enrica Antolini, Simona Letizia Basso, Samantha Minetto, Giulia Rollo, Martina Rozza, Angela Rina, Rossella Tita, Maria Antonietta Mencarelli, Caterina Lo Rizzo, Anna Maria Pinto, Francesca Ariani, Francesca Montagnani, Mario Tumbarello, Ilaria Rancan, Massimiliano Fabbiani, Elena Bargagli, Laura Bergantini, Miriana d’Alessandro, Paolo Cameli, David Bennett, Federico Anedda, Simona Marcantonio, Sabino Scolletta, Federico Franchi, Maria Antonietta Mazzei, Susanna Guerrini, Edoardo Conticini, Luca Cantarini, Bruno Frediani, Danilo Tacconi, Chiara Spertilli Raffaelli, Arianna Emiliozzi, Marco Feri, Alice Donati, Raffaele Scala, Luca Guidelli, Genni Spargi, Marta Corridi, Cesira Nencioni, Leonardo Croci, Gian Piero Caldarelli, Davide Romani, Paolo Piacentini, Maria Bandini, Elena Desanctis, Silvia Cappelli, Anna Canaccini, Agnese Verzuri, Valentina Anemoli, Manola Pisani, Agostino Ognibene, Maria Lorubbio, Alessandro Pancrazzi, Massimo Vaghi, Antonella D’Arminio Monforte, Federica Gaia Miraglia, Mario U. Mondelli, Stefania Mantovani, Raffaele Bruno, Marco Vecchia, Marcello Maffezzoni, Enrico Martinelli, Massimo Girardis, Stefano Busani, Sophie Venturelli, Andrea Cossarizza, Andrea Antinori, Alessandra Vergori, Stefano Rusconi, Matteo Siano, Arianna Gabrieli, Agostino Riva, Daniela Francisci, Elisabetta Schiaroli, Carlo Pallotto, Saverio Giuseppe Parisi, Monica Basso, Sandro Panese, Stefano Baratti, Pier Giorgio Scotton, Francesca Andretta, Mario Giobbia, Renzo Scaggiante, Francesca Gatti, Francesco Castelli, Eugenia Quiros-Roldan, Melania Degli Antoni, Isabella Zanella, Matteo della Monica, Carmelo Piscopo, Mario Capasso, Roberta Russo, Immacolata Andolfo, Achille Iolascon, Giuseppe Fiorentino, Massimo Carella, Marco Castori, Giuseppe Merla, Gabriella Maria Squeo, Filippo Aucella, Pamela Raggi, Rita Perna, Matteo Bassetti, Antonio Di Biagio, Maurizio Sanguinetti, Luca Masucci, Alessandra Guarnaccia, Serafina Valente, Alex Di Florio, Marco Mandalà, Alessia Giorli, Lorenzo Salerni, Patrizia Zucchi, Pierpaolo Parravicini, Elisabetta Menatti, Tullio Trotta, Ferdinando Giannattasio, Gabriella Coiro, Fabio Lena, Gianluca Lacerenza, Cristina Mussini, Luisa Tavecchia, Lia Crotti, Gianfranco Parati, Roberto Menè, Maurizio Sanarico, Marco Gori, Francesco Raimondi, Alessandra Stella, Filippo Biscarini, Tiziana Bachetti, Maria Teresa La Rovere, Maurizio Bussotti, Serena Ludovisi, Katia Capitani, Simona Dei, Sabrina Ravaglia, Annarita Giliberti, Giulia Gori, Rosangela Artuso, Elena Andreucci, Angelica Pagliazzi, Erika Fiorentini, Antonio Perrella, Francesco Bianchi, Paola Bergomi, Emanuele Catena, Riccardo Colombo, Sauro Luchi, Giovanna Morelli, Paola Petrocelli, Sarah Iacopini, Sara Modica, Silvia Baroni, Giulia Micheli, Marco Falcone, Donato Urso, Giusy Tiseo, Tommaso Matucci, Davide Grassi, Claudio Ferri, Franco Marinangeli, Francesco Brancati, Antonella Vincenti, Valentina Borgo, Stefania Lombardi, Mirco Lenzi, Massimo Antonio Di Pietro, Francesca Vichi, Benedetta Romanin, Letizia Attala, Cecilia Costa, Andrea Gabbuti, Alessio Bellucci, Marta Colaneri, Patrizia Casprini, Cristoforo Pomara, Massimiliano Esposito, Roberto Leoncini, Michele Cirianni, Lucrezia Galasso, Marco Antonio Bellini, Chiara Gabbi, and Nicola Picchiotti
Subjects: COVID-19, host genetics, integrated polygenic score, genetic algorithm, logistic regression, genetic science modeling, Genetics, QH426-470
Abstract: The impact of common and rare variants in COVID-19 host genetics has been widely studied. In particular, in Fallerini et al. (Human genetics, 2022, 141, 147–173), common and rare variants were used to define an interpretable machine learning model for predicting COVID-19 severity. First, variants were converted into sets of Boolean features, depending on the absence or the presence of variants in each gene. An ensemble of LASSO logistic regression models was used to identify the most informative Boolean features with respect to the genetic bases of severity. After that, the Boolean features, selected by these logistic models, were combined into an Integrated PolyGenic Score (IPGS), which offers a very simple description of the contribution of host genetics in COVID-19 severity.. IPGS leads to an accuracy of 55%–60% on different cohorts, and, after a logistic regression with both IPGS and age as inputs, it leads to an accuracy of 75%. The goal of this paper is to improve the previous results, using not only the most informative Boolean features with respect to the genetic bases of severity but also the information on host organs involved in the disease. In this study, we generalize the IPGS adding a statistical weight for each organ, through the transformation of Boolean features into “Boolean quantum features,” inspired by quantum mechanics. The organ coefficients were set via the application of the genetic algorithm PyGAD, and, after that, we defined two new integrated polygenic scores (IPGSph1 and IPGSph2). By applying a logistic regression with both IPGS, (IPGSph2 (or indifferently IPGSph1) and age as inputs, we reached an accuracy of 84%–86%, thus improving the results previously shown in Fallerini et al. (Human genetics, 2022, 141, 147–173) by a factor of 10%.
Published: 2024
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22. Risk of COVID-19 in-hospital mortality in people living with HIV compared to general population according to age and CD4 strata: data from the ICONA network

Author: Andrea Giacomelli, Roberta Gagliardini, Alessandro Tavelli, Sara De Benedittis, Valentina Mazzotta, Giuliano Rizzardini, Annalisa Mondi, Matteo Augello, Spinello Antinori, Alessandra Vergori, Andrea Gori, Marianna Menozzi, Lucia Taramasso, Francesco Maria Fusco, Andrea De Vito, Giulia Mancarella, Giulia Marchetti, Antonella D'Arminio Monforte, Andrea Antinori, and Alessandro Cozzi-Lepri
Subjects: SARS-CoV-2, Death, Hospitalization, Immunodepression, People living with HIV, Infectious and parasitic diseases, RC109-216
Abstract: Objectives: We aimed to study whether people living with HIV (PLWH) are at higher risk of in-hospital COVID-19 mortality compared to the general population (GenPop). Methods: This was a retrospective study in 19 Italian centers (February 2020 to November 2022) including hospitalized PLWH and GenPop with SARS-CoV-2 infection. The main outcome was in-hospital mortality. Competing risk analyses by Fine-Gray regression model were used to estimate the association between in-hospital mortality and HIV status/age. Results: A total of 7399 patients with COVID-19 were included, 239 (3.2%) PLWH, and 7160 (96.8%) GenPop. By day 40, in-hospital death occurred in 1283/7160 (17.9%) among GenPop and 34/239 (14.2%) among PLWH. After adjusting for potential confounders, compared to GenPop 350 (aSHR 1.11 [95% CI 0.41-2.99]). Conclusions: In PLWH aged
Published: 2023
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23. Efficacy and Safety of Reparixin in Patients with Severe COVID-19 Pneumonia: A Phase 3, Randomized, Double-Blind Placebo-Controlled Study

Author: Piemonti, Lorenzo, Landoni, Giovanni, Voza, Antonio, Puoti, Massimo, Gentile, Ivan, Coppola, Nicola, Nava, Stefano, Mattei, Alessia, Marinangeli, Franco, Marchetti, Giulia, Bonfanti, Paolo, Mastroianni, Claudio Maria, Bassetti, Matteo, Crisafulli, Ernesto, Grossi, Paolo Antonio, Zangrillo, Alberto, Desai, Antonio, Merli, Marco, Foggia, Maria, Carpano, Marco, Schiavoni, Lorenzo, D’Arminio Monforte, Antonella, Bisi, Luca, Russo, Gianluca, Busti, Fabiana, Rovelli, Cristina, Perrotta, Elisabetta, Goisis, Giovanni, Gavioli, Elizabeth M., Toya, Sophie, De Pizzol, Maria, Mantelli, Flavio, Allegretti, Marcello, and Minnella, Enrico Maria
Published: 2023
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24. Associations between change in BMI and the risk of hypertension and dyslipidaemia in people receiving integrase strand-transfer inhibitors, tenofovir alafenamide, or both compared with other contemporary antiretroviral regimens: a multicentre, prospective observational study from the RESPOND consortium cohorts

Author: Byonanebye, Dathan M, Polizzotto, Mark N, Maltez, Fernando, Rauch, Andri, Grabmeier-Pfistershammer, Katharina, Wit, Ferdinand, De Wit, Stéphane, Castagna, Antonella, d'Arminio Monforte, Antonella, Mussini, Cristina, Wasmuth, Jan-Christian, Fontas, Eric, Abela, Irene, Sarcletti, Mario, Bansi-Matharu, Loveleen, Jaschinski, Nadine, Peters, Lars, Hosein, Sean R, Vannappagari, Vani, Cohen, Cal, Bissio, Emiliano, Mocroft, Amanda, Law, Matthew, Ryom, Lene, and Petoumenos, Kathy
Published: 2024
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25. Association between tight junction proteins and cognitive performance in untreated persons with HIV

Author: Bai, Francesca, Bono, Valeria, Borghi, Lidia, Bonazza, Federica, Falcinella, Camilla, Vitaletti, Virginia, Miraglia, Federica, Trunfio, Mattia, Calcagno, Andrea, Cusato, Jessica, Vegni, Elena, d’Arminio Monforte, Antonella, and Marchetti, Giulia
Published: 2024
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26. Longitudinal trends in causes of death among adults with HIV on antiretroviral therapy in Europe and North America from 1996 to 2020: a collaboration of cohort studies

Author: Trickey, Adam, McGinnis, Kathleen, Gill, M John, Abgrall, Sophie, Berenguer, Juan, Wyen, Christoph, Hessamfar, Mojgan, Reiss, Peter, Kusejko, Katharina, Silverberg, Michael J, Imaz, Arkaitz, Teira, Ramon, d'Arminio Monforte, Antonella, Zangerle, Robert, Guest, Jodie L, Papastamopoulos, Vasileios, Crane, Heidi, Sterling, Timothy R, Grabar, Sophie, Ingle, Suzanne M, and Sterne, Jonathan A C
Published: 2024
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27. Impact of COVID-19 pandemic on retention in care of native and migrant people with HIV in the ICONA cohort

Author: Gagliardini, Roberta, Giacomelli, Andrea, Bozzi, Giorgio, D'Arminio Monforte, Antonella, Tavelli, Alessandro, Mazzotta, Valentina, Bruzzesi, Elena, Cervo, Adriana, Saracino, Annalisa, Mussini, Cristina, Girardi, Enrico, Cozzi-Lepri, Alessandro, and Antinori, Andrea
Published: 2024
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28. EuCARE-POSTCOVID Study: a multicentre cohort study on long-term post-COVID-19 manifestations

Author: Benedetta Varisco, Francesca Bai, Sara De Benedittis, Alessandro Tavelli, Alessandro Cozzi-Lepri, Matteo Sala, Federica Gaia Miraglia, Maria Mercedes Santoro, Francesca Ceccherini-Silberstein, Yishai Shimoni, Sivan Ravid, Tal Kozlovski, Florian König, Nico Pfeifer, Elham Shamsara, Milosz Parczewski, Antonella d’Arminio Monforte, Francesca Incardona, Chiara Mommo, and Giulia Marchetti
Subjects: Post-COVID-19 condition, Post Acute Sequelae of SARS CoV-2 infection, Long COVID, Residual organ damage in COVID-19, Follow-up after COVID-19, Persistence of COVID-19 symptoms, Infectious and parasitic diseases, RC109-216
Abstract: Abstract Background Post-COVID-19 condition refers to persistent or new onset symptoms occurring three months after acute COVID-19, which are unrelated to alternative diagnoses. Symptoms include fatigue, breathlessness, palpitations, pain, concentration difficulties ("brain fog"), sleep disorders, and anxiety/depression. The prevalence of post-COVID-19 condition ranges widely across studies, affecting 10–20% of patients and reaching 50–60% in certain cohorts, while the associated risk factors remain poorly understood. Methods This multicentre cohort study, both retrospective and prospective, aims to assess the incidence and risk factors of post-COVID-19 condition in a cohort of recovered patients. Secondary objectives include evaluating the association between circulating SARS-CoV-2 variants and the risk of post-COVID-19 condition, as well as assessing long-term residual organ damage (lung, heart, central nervous system, peripheral nervous system) in relation to patient characteristics and virology (variant and viral load during the acute phase). Participants will include hospitalised and outpatient COVID-19 patients diagnosed between 01/03/2020 and 01/02/2025 from 8 participating centres. A control group will consist of hospitalised patients with respiratory infections other than COVID-19 during the same period. Patients will be followed up at the post-COVID-19 clinic of each centre at 2–3, 6–9, and 12–15 months after clinical recovery. Routine blood exams will be conducted, and patients will complete questionnaires to assess persisting symptoms, fatigue, dyspnoea, quality of life, disability, anxiety and depression, and post-traumatic stress disorders. Discussion This study aims to understand post-COVID-19 syndrome's incidence and predictors by comparing pandemic waves, utilising retrospective and prospective data. Gender association, especially the potential higher prevalence in females, will be investigated. Symptom tracking via questionnaires and scales will monitor duration and evolution. Questionnaires will also collect data on vaccination, reinfections, and new health issues. Biological samples will enable future studies on post-COVID-19 sequelae mechanisms, including inflammation, immune dysregulation, and viral reservoirs. Trial registration This study has been registered with ClinicalTrials.gov under the identifier NCT05531773.
Published: 2023
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29. Differences in clinical characteristics and quantitative lung CT features between vaccinated and not vaccinated hospitalized COVID-19 patients in Italy

Author: Chiumello, Davide, Tavelli, Alessandro, Serio, Lorenzo, De Benedittis, Sara, Pozzi, Tommaso, Maj, Roberta, Velati, Mara, Brusatori, Serena, D’Albo, Rosanna, Zinnato, Carmelo, Marchetti, Giulia, Camporota, Luigi, Coppola, Silvia, and D’Arminio Monforte, Antonella
Published: 2023
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30. Association between SARS-CoV-2 RNAemia, skewed T cell responses, inflammation, and severity in hospitalized COVID-19 people living with HIV

Author: Augello, Matteo, Bono, Valeria, Rovito, Roberta, Tincati, Camilla, Bianchi, Silvia, Taramasso, Lucia, Di Biagio, Antonio, Callegaro, Annapaola, Maggiolo, Franco, Borghi, Elisa, Monforte, Antonella d’Arminio, and Marchetti, Giulia
Published: 2024
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31. Characterization and outcomes of difficult-to-treat patients starting modern first-line ART regimens: Data from the ICONA cohort

Author: Gagliardini, Roberta, Tavelli, Alessandro, Rusconi, Stefano, Lo Caputo, Sergio, Spagnuolo, Vincenzo, Santoro, Maria Mercedes, Costantini, Andrea, Vergori, Alessandra, Maggiolo, Franco, Giacomelli, Andrea, Burastero, Giulia, Madeddu, Giordano, Quiros Roldan, Eugenia, d'Arminio Monforte, Antonella, Antinori, Andrea, and Cozzi-Lepri, Alessandro
Published: 2024
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32. Heavy antiretroviral exposure and exhausted/limited antiretroviral options: predictors and clinical outcomes

Author: Mocroft, Amanda, Pelchen-Matthews, Annegret, Hoy, Jennifer, Llibre, Josep M., Neesgaard, Bastian, Jaschinski, Nadine, Domingo, Pere, Rasmussen, Line Dahlerup, Günthard, Huldrych F., Surial, Bernard, Öllinger, Angela, Knappik, Michael, de Wit, Stephane, Wit, Ferdinand, Mussini, Cristina, Vehreschild, Joerg, Monforte, Antonella D’Arminio, Sonnerborg, Anders, Castagna, Antonella, Anne, Alain Volny, Vannappagari, Vani, Cohen, Cal, Greaves, Wayne, Wasmuth, Jan C., Spagnuolo, Vincenzo, and Ryom, Lene
Published: 2024
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33. Integrase strand-transfer inhibitor use and cardiovascular events in adults with HIV: an emulation of target trials in the HIV-CAUSAL Collaboration and the Antiretroviral Therapy Cohort Collaboration

Author: Rein, Sophia M, Lodi, Sara, Logan, Roger W, Touloumi, Giota, Antoniadou, Anastasia, Wittkop, Linda, Bonnet, Fabrice, van Sighem, Ard, van der Valk, Marc, Reiss, Peter, Klein, Marina B, Young, James, Jarrin, Inmaculada, d'Arminio Monforte, Antonella, Tavelli, Alessandro, Meyer, Laurence, Tran, Laurent, Gill, Michael J, Lang, Raynell, Surial, Bernard, Haas, Andreas D, Justice, Amy C, Rentsch, Christopher T, Phillips, Andrew, Sabin, Caroline A, Miro, Jose M, Trickey, Adam, Ingle, Suzanne M, Sterne, Jonathan A C, and Hernán, Miguel A
Published: 2023
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34. HIV-1 drug resistance in people on dolutegravir-based antiretroviral therapy: a collaborative cohort analysis

Author: Loosli, Tom, Hossmann, Stefanie, Ingle, Suzanne M, Okhai, Hajra, Kusejko, Katharina, Mouton, Johannes, Bellecave, Pantxika, van Sighem, Ard, Stecher, Melanie, d'Arminio Monforte, Antonella, Gill, M John, Sabin, Caroline A, Maartens, Gary, Günthard, Huldrych F, Sterne, Jonathan A C, Lessells, Richard, Egger, Matthias, and Kouyos, Roger D
Published: 2023
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35. Pillars of long-term antiretroviral therapy success

Author: Taramasso, Lucia, Andreoni, Massimo, Antinori, Andrea, Bandera, Alessandra, Bonfanti, Paolo, Bonora, Stefano, Borderi, Marco, Castagna, Antonella, Cattelan, Anna Maria, Celesia, Benedetto Maurizio, Cicalini, Stefania, Cingolani, Antonella, Cossarizza, Andrea, D'Arminio Monforte, Antonella, D'Ettorre, Gabriella, Di Biagio, Antonio, Di Giambenedetto, Simona, Di Perri, Giovanni, Esposito, Vincenzo, Focà, Emanuele, Gervasoni, Cristina, Gori, Andrea, Gianotti, Nicola, Guaraldi, Giovanni, Gulminetti, Roberto, Lo Caputo, Sergio, Madeddu, Giordano, Maggi, Paolo, Marandola, Giorgio, Marchetti, Giulia Carla, Mastroianni, Claudio Maria, Mussini, Cristina, Perno, Carlo Federico, Rizzardini, Giuliano, Rusconi, Stefano, Santoro, Maria, Sarmati, Loredana, Zazzi, Maurizio, and Maggiolo, Franco
Published: 2023
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36. Standardizing macromolecular structure files: further efforts are needed

Author: D’Arminio, Nancy, Giordano, Deborah, Scafuri, Bernardina, Facchiano, Angelo, and Marabotti, Anna
Published: 2023
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37. Life expectancy after 2015 of adults with HIV on long-term antiretroviral therapy in Europe and North America: a collaborative analysis of cohort studies

Author: Trickey, Adam, Sabin, Caroline A, Burkholder, Greer, Crane, Heidi, d'Arminio Monforte, Antonella, Egger, Matthias, Gill, M John, Grabar, Sophie, Guest, Jodie L, Jarrin, Inma, Lampe, Fiona C, Obel, Niels, Reyes, Juliana M, Stephan, Christoph, Sterling, Timothy R, Teira, Ramon, Touloumi, Giota, Wasmuth, Jan-Christian, Wit, Ferdinand, Wittkop, Linda, Zangerle, Robert, Silverberg, Michael J, Justice, Amy, and Sterne, Jonathan A C
Published: 2023
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38. An automated pipeline integrating AlphaFold 2 and MODELLER for protein structure prediction

Author: Fabio Hernan Gil Zuluaga, Nancy D’Arminio, Francesco Bardozzo, Roberto Tagliaferri, and Anna Marabotti
Subjects: Protein structure prediction, Deep learning, MODELLER, AlphaFold 2, Biotechnology, TP248.13-248.65
Abstract: The ability to predict a protein's three-dimensional conformation represents a crucial starting point for investigating evolutionary connections with other members of the corresponding protein family, examining interactions with other proteins, and potentially utilizing this knowledge for the purpose of rational drug design. In this work, we evaluated the feasibility of improving AlphaFold2’s three-dimensional protein predictions by developing a novel pipeline (AlphaMod) that incorporates AlphaFold2 with MODELLER, a template-based modeling program. Additionally, our tool can drive a comprehensive quality assessment of the tertiary protein structure by incorporating and comparing a set of different quality assessment tools. The outcomes of selected tools are combined into a composite score (BORDASCORE) that exhibits a meaningful correlation with GDT_TS and facilitates the selection of optimal models in the absence of a reference structure. To validate AlphaMod's results, we conducted evaluations using two distinct datasets summing up to 72 targets, previously used to independently assess AlphaFold2's performance. The generated models underwent evaluation through two methods: i) averaging the GDT_TS scores across all produced structures for a single target sequence, and ii) a pairwise comparison of the best structures generated by AlphaFold2 and AlphaMod. The latter, within the unsupervised setups, shows a rising accuracy of approximately 34% over AlphaFold2. While, when considering the supervised setup, AlphaMod surpasses AlphaFold2 in 18% of the instances. Finally, there is an 11% correspondence in outcomes between the diverse methodologies. Consequently, AlphaMod’s best-predicted tertiary structures in several cases exhibited a significant improvement in the accuracy of the predictions with respect to the best models obtained by AlphaFold2. This pipeline paves the way for the integration of additional data and AI-based algorithms to further improve the reliability of the predictions.
Published: 2023
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39. Mpox in people with advanced HIV infection: a global case series

Author: Leiro, Viviana, Marchetta, Lucila, Fernandez Pardal, Patricia, Figueroa, María Inés, Cahn, Pedro, Grabmeier-Pfistershammer, Katharina, Libois, Agnes, Liesenborghs, Laurens, Grinsztejn, Beatriz, Schechter, Mauro, dos Santos de Lemos, Alberto, Furtado Costa, Alvaro, Queiroz Rocha, Simone, Valdez Madruga, José, S. Tan, Darrell H., Mishra, Sharmistha, Shah, Shreya, Jorquera, Camila, Castillo, Alberto, Carrión, Mauricio, Cevallos, Nelson, Palich, Romain, Pourcher, Valerie, Rubenstein, Emma, Migaud, Pascal, Boesecke, Christoph, Hoffmann, Christian, Protopapas, Konstantinos, Nozza, Silvia, Cattelan, Anna Maria, Mussini, Cristina, d'Arminio Monforte, Antonella, Cruz Flores, Raúl Adrian, Pérez Barragán, Edgar, Rodríguez Guzmán, Alma Leticia, Ogoina, Dimie, Chika-Igwenyi, Nneka Marian, Chizaram, Onyeaghala, Valverde López, Jenny, García Tello, Angelica, Ubals, Maria, Vall, Martí, Mendoza, Adrià, Suñer, Clara, Clotet, Bonaventura, Bechini, Jordi, Lepe, Jose A, Navarro-Amuedo, M. Dolores, Bernadino, Jose Ignacio, Català, Alba, Tarín Vicente, Eloy José, González Rodríguez, Borja, Rodriguez-Mercader, Sergi, Sánchez-Martinez, Francisca, Cañas-Ruano, Esperanza, Parra-Navarro, Laura, Filén, Finn, Tallón de Lara, Carmen, Braun, Dominique, Piezzi, Vanja, Burkhard, Michael, Kovari, Helen, Mönch, Anja, Dunning, Jake, Simoes, Pedro, Nori, Achyuta, Keegan, Sarah, Thornhill, John P, Apea, Vanessa, Noori, Teymur, Jones, Joyce L., Judson, Seth, Gilliams, Elizabeth A., Hamill, Matthew M., Keruly, Jeanne, Henao Martínez, Andrés F., Lin, Aung, So, Jessica, Davar, Kusha, Villareal, Diana, Tapia Paredes, Miguel, Mitjà, Oriol, Alemany, Andrea, Marks, Michael, Lezama Mora, Jezer I, Rodríguez-Aldama, Juan Carlos, Torres Silva, Mayara Secco, Corral Herrera, Ever Arturo, Crabtree-Ramirez, Brenda, Blanco, José Luis, Girometti, Nicolo, Mazzotta, Valentina, Hazra, Aniruddha, Silva, Macarena, Montenegro-Idrogo, Juan José, Gebo, Kelly, Ghosn, Jade, Peña Vázquez, María Fernanda, Matos Prado, Eduardo, Unigwe, Uche, Villar-García, Judit, Wald-Dickler, Noah, Zucker, Jason, Paredes, Roger, Calmy, Alexandra, Waters, Laura, Galvan-Casas, Cristina, Walmsley, Sharon, and Orkin, Chloe M
Published: 2023
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40. Sarilumab plus standard of care vs standard of care for the treatment of severe COVID-19: a phase 3, randomized, open-labeled, multi-center study (ESCAPE study)

Author: Agrati, Chiara, Andreoni, Massimo, Antinori, Andrea, Bai, Francesca, Beccacece, Alessia, Barreca, Filippo, Bertuccio, Maria Paola, Bini, Teresa, Boumis, Evangelo, Camici, Marta, Cauda, Roberto, Cerva, Carlotta, Cicalini, Stefania, Cingolani, Antonella, D'Arminio Monforte, Antonella, D'Urso, Angela, De Masi, Margherita, De Zottis, Federico, Del Borgo, Cosmo, Di Gennaro, Francesco, Emiliozzi, Arianna, Fantoni, Massimo, Fondaco, Laura, Fusto, Marisa, Gagliardini, Roberta, Giovannenze, Francesca, Grilli, Elisabetta, Iannetta, Marco, Iodice, Daniele, Lichtner, Miriam, Lorenzini, Patrizia, Maffongelli, Gaetano, Masone, Erminia, Massa, Barbara, Mastrorosa, Ilaria, Mazzotta, Valentina, Mencarini, Paola, Milozzi, Eugenia, Mondi, Annalisa, Mosti, Silvia, Murri, Rita, Negri, Marcantonio, Nicastri, Emanuele, Oliva, Gian Piero, Onnelli, Giovanna, Ottou, Sandrine, Pace, Pier Giorgio, Palmieri, Fabrizio, Paulicelli, Jessica, Pinnetti, Carmela, Plazzi, Maria Maddalena, Sarmati, Loredana, Segala, Francesco Vladimiro, Sorace, Chiara, Taddei, Eleonora, Vergori, Alessandra, Vitale, Pietro, Lamonica, Silvia, Girardi, Enrico, and Vaia, Francesco
Published: 2023
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41. Bacterial Patterns and Empiric Antibiotic Use in COPD Patients With Community-Acquired Pneumonia

Author: Aruj, Patricia Karina, Attorri, Silvia, Barimboim, Enrique, Caeiro, Juan Pablo, Garzón, María I., Cambursano, Victor Hugo, Ceccato, Adrian, Chertcoff, Julio, Lascar, Florencia, Tulio, Fernando Di, Díaz, Ariel Cordon, Vedia, Lautaro de, Ganaha, Maria Cristina, Lambert, Sandra, Lopardo, Gustavo, Luna, Carlos M., Malberti, Alessio Gerardo, Morcillo, Nora, Tartara, Silvina, Pensotti, Claudia, Pereyra, Betiana, Scapellato, Pablo Gustavo, Stagnaro, Juan Pablo, Shah, Sonali, Lötsch, Felix, Thalhammer, Florian, Anseeuw, Kurt, Francois, Camille A., Braeckel, Eva Van, Vincent, Jean Louis, Djimon, Marcel Zannou, Bashi, Jules, Dodo, Roger, Nouér, Simone Aranha, Chipev, Peter, Encheva, Milena, Miteva, Darina, Petkova, Diana, Balkissou, Adamou Dodo, Pefura Yone, Eric Walter, Mbatchou Ngahane, Bertrand Hugo, Shen, Ning, Xu, Jin-fu, Bustamante Rico, Carlos Andres, Buitrago, Ricardo, Pereira Paternina, Fernando Jose, Kayembe Ntumba, Jean-Marie, Carevic, Vesna Vladic, Jakopovic, Marko, Jankovic, Mateja, Matkovic, Zinka, Mitrecic, Ivan, Bouchy Jacobsson, Marie-Laure, Christensen, Anette Bro, Bødtger, Uffe, Meyer, Christian Niels, Jensen, Andreas Vestergaard, Baunbæk-knudsen, Gertrud, Petersen, Pelle Trier, Andersen, Stine, Abd El-Wahhab, Ibrahim El-Said, Morsy, Nesreen Elsayed, Shafiek, Hanaa, Sobh, Eman, Abdulsemed, Kedir Abdella, Bertrand, Fabrice, Brun-Buisson, Christian, Montmollin, Etienne de, Fartoukh, Muriel, Messika, Jonathan, Tattevin, Pierre, Khoury, Abdo, Ebruke, Bernard, Dreher, Michael, Kolditz, Martin, Meisinger, Matthias, Pletz, Mathias W., Hagel, Stefan, Rupp, Jan, Schaberg, Tom, Spielmanns, Marc, Creutz, Petra, Suttorp, Norton, Siaw-Lartey, Beatrice, Dimakou, Katerina, Gaga, Mina, Papapetrou, Dimosthenis, Tsigou, Evdoxia, Ampazis, Dimitrios, Kaimakamis, Evangelos, Bhatia, Mohit, Dhar, Raja, D'Souza, George, Garg, Rajiv, Koul, Parvaiz A., Mahesh, P.A., Jayaraj, B.S., Narayan, Kiran Vishnu, Udnur, Hirennappa B., Krishnamurthy, Shashi Bhaskara, Kant, Surya, Swarnakar, Rajesh, Limaye, Sneha, Salvi, Sundeep, Golshani, Keihan, Keatings, Vera M., Martin-Loeches, Ignacio, Maor, Yasmin, Strahilevitz, Jacob, Battaglia, Salvatore, Carrabba, Maria, Ceriana, Piero, Confalonieri, Marco, Monforte, Antonella d’Arminio, Prato, Bruno Del, Rosa, Marino De, Fantini, Riccardo, Faverio, Paola, Fiorentino, Giuseppe, Gammino, Maria Antonia, Menzella, Francesco, Milani, Giuseppe, Nava, Stefano, Palmiero, Gerardo, Petrino, Roberta, Gabrielli, Barbara, Rossi, Paolo, Sorino, Claudio, Steinhilber, Gundi, Zanforlin, Alessandro, Franzetti, Fabio, Carugati, Manuela, Morosi, Manuela, Monge, Elisa, Carone, Mauro, Patella, Vincenzo, Scarlata, Simone, Comel, Andrea, Kurahashi, Kiyoyasu, Bacha, Zeina Aoun, Ugalde, Daniel Barajas, Zuñiga, Omar Ceballos, Villegas, José F., Medenica, Milic, Garde, E.M.W. van de, Mihsra, Deebya Raj, Shrestha, Poojan, Ridgeon, Elliott, Awokola, Babatunde Ishola, Nwankwo, Ogonna N.O., Olufunlola, Adefuye Bolanle, Olumide, Segaolu, Ukwaja, Kingsley N., Irfan, Muhammad, Minarowski, Lukasz, Szymon, Skoczyński, Froes, Felipe, Leuschner, Pedro, Meireles, Mariana, Ferrão, Cláudia, Neves, João, Ravara, Sofia B., Brocovschii, Victoria, Ion, Chesov, Rusu, Doina, Toma, Cristina, Chirita, Daniela, Dorobat, Carmen Mihaela, Birkun, Alexei, Kaluzhenina, Anna, Almotairi, Abdullah, Ali Bukhary, Zakeya Abdulbaqi, Edathodu, Jameela, Fathy, Amal, Abdulaziz Enani, Abdullah Mushira, Mohamed, Nazik Eltayeb, Memon, Jawed Ulhadi, Bella, Abdelhaleem, Bogdanović, Nada, Milenkovic, Branislava, Pesut, Dragica, Borderìas, Luis, Bordon Garcia, Noel Manuel, Alarcón, Hugo Cabello, Cilloniz, Catia, Torres, Antoni, Diaz-Brito, Vicens, Casas, Xavier, González, Alicia Encabo, Fernández-Almira, Maria Luisa, Gallego, Miguel, Gaspar-García, Inmaculada, Castillo, Juan González del, Victoria, Patricia Javaloyes, Martínez, Elena Laserna, Molina, Rosa Malo de, Marcos, Pedro J., Menéndez, Rosario, Pando-Sandoval, Ana, Aymerich, Cristina Prat, Torre, Alicia Lacoma de la, García-Olivé, Ignasi, Rello, Jordi, Moyano, Silvia, Sanz, Francisco, Sibila, Oriol, Rodrigo-Troyano, Ana, Solé-Violán, Jordi, Uranga, Ane, Boven, Job F.M. van, Torra, Ester Vendrell, Pujol, Jordi Almirall, Feldman, Charles, Yum, Ho Kee, Fiogbe, Arnauld Attannon, Yangui, Ferdaous, Bilaceroglu, Semra, Dalar, Levent, Yilmaz, Ufuk, Bogomolov, Artemii, Elahi, Naheed, Dhasmana, Devesh J., Feneley, Andrew, Ions, Rhiannon, Skeemer, Julie, Woltmann, Gerrit, Hancock, Carole, Hill, Adam T., Rudran, Banu, Ruiz-Buitrago, Silvia, Campbell, Marion, Whitaker, Paul, Youzguin, Alexander, Singanayagam, Anika, Allen, Karen S., Brito, Veronica, Dietz, Jessica, Dysart, Claire E., Kellie, Susan M., Franco-Sadud, Ricardo A., Meier, Garnet, Holland, Thomas L., Bergin, Stephen P., Kheir, Fayez, Landmeier, Mark, Lois, Manuel, Nair, Girish B., Patel, Hemali, Reyes, Katherine, Rodriguez-Cintron, William, Saito, Shigeki, Soni, Nilam J., Noda, Julio, Hinojosa, Cecilia I., Levine, Stephanie M., Angel, Luis F., Reyes, Luis F., Anzueto, Antonio, Whitlow, K. Scott, Hipskind, John, Sukhija, Kunal, Totten, Vicken, Wunderink, Richard G., Shah, Ray D., Mateyo, Kondwelani John, Noriega, Lorena, Alvarado, Ezequiel, Aman, Mohamed, Labra, Lucía, Pascual-Guardia, Sergi, Amati, Francesco, Marin-Corral, Judith, Aliberti, Stefano, Gea, Joaquim, Rodriguez, Alejandro, Sotgiu, Giovanni, Meyer, Christian N., Anzueto, Antonio R., and Restrepo, Marcos I.
Published: 2023
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42. Association between SARS-CoV-2 RNAemia and dysregulated immune response in acutely ill hospitalized COVID-19 patients

Author: Roberta Rovito, Valeria Bono, Matteo Augello, Camilla Tincati, Federica Mainoldi, Guillaume Beaudoin-Bussières, Alexandra Tauzin, Silvia Bianchi, Mohamad Hadla, Vaibhav Yellenki, Antonella d’Arminio Monforte, Stefano Casola, Elisa Borghi, Andrés Finzi, and Giulia Marchetti
Subjects: Medicine, Science
Abstract: Abstract Severe/critical COVID-19 is associated with immune dysregulation and plasmatic SARS-CoV-2 detection (i.e. RNAemia). We detailed the association of SARS-CoV-2 RNAemia with immune responses in COVID-19 patients at the end of the first week of disease. We enrolled patients hospitalized in acute phase of ascertained SARS-CoV-2 pneumonia, and evaluated SARS-CoV-2 RNAemia, plasmatic cytokines, activated/pro-cytolytic T-cells phenotypes, SARS-CoV-2-specific cytokine-producing T-cells (IL-2, IFN-γ, TNF-α, IL-4, IL-17A), simultaneous Th1-cytokines production (polyfunctionality) and amount (iMFI). The humoral responses were assessed with anti-S1/S2 IgG, anti-RBD total-Ig, IgM, IgA, IgG1 and IgG3, neutralization and antibody-dependent cellular cytotoxicity (ADCC). Out of 54 patients, 27 had detectable viremia (viremic). Albeit comparable age and co-morbidities, viremic more frequently required ventilatory support, with a trend to higher death. Viremic displayed higher pro-inflammatory cytokines (IFN-α, IL-6), lower activated T-cells (HLA-DR+CD38+), lower functional SARS-CoV-2-specific T-cells (IFN-γ+CD4+, TNF-α+CD8+, IL-4+CD8+, IL-2+TNF-α+CD4+, and IL-2+TNF-α+CD4+ iMFI) and SARS-CoV-2-specific Abs (anti-S IgG, anti-RBD total-Ig, IgM, IgG1, IgG3; ID50, %ADCC). These data suggest a link between SARS-CoV-2 RNAemia at the end of the first stage of disease and immune dysregulation. Whether high ab initium viral burden and/or intrinsic host factors contribute to immune dysregulation in severe COVID-19 remains to be elucidated, to further inform strategies of targeted therapeutic interventions.
Published: 2022
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43. A Multicenter Phase 2 Randomized Controlled Study on the Efficacy and Safety of Reparixin in the Treatment of Hospitalized Patients with COVID-19 Pneumonia

Author: Landoni, Giovanni, Piemonti, Lorenzo, Monforte, Antonella d’Arminio, Grossi, Paolo, Zangrillo, Alberto, Bucci, Enrico, Allegretti, Marcello, Goisis, Giovanni, Gavioli, Elizabeth M., Patel, Neal, De Pizzol, Maria, Pasedis, Georgea, and Mantelli, Flavio
Published: 2022
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44. Six-month immune responses to mRNA-1273 Vaccine in cART-treated late presenter people living with HIV according to previous SARS-CoV-2 Infection

Author: Augello, Matteo, Bono, Valeria, Rovito, Roberta, Tincati, Camilla, Monforte, Antonella D’arminio, and Marchetti, Giulia
Published: 2023
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45. What is the impact of SARS-CoV-2 pandemic on antimicrobial stewardship programs (ASPs)? The results of a survey among a regional network of infectious disease centres

Author: Agnese Comelli, Camilla Genovese, Andrea Lombardi, Chiara Bobbio, Luigia Scudeller, Umberto Restelli, Antonio Muscatello, Spinello Antinori, Paolo Bonfanti, Salvatore Casari, Antonella Castagna, Francesco Castelli, Antonella d’Arminio Monforte, Fabio Franzetti, Paolo Grossi, Matteo Lupi, Paola Morelli, Stefania Piconi, Massimo Puoti, Luigi Pusterla, Angelo Regazzetti, Marco Rizzi, Stefano Rusconi, Valentina Zuccaro, Andrea Gori, Alessandra Bandera, and the ASP Lomb Study Group
Subjects: COVID-19, SARS-CoV-2, Antimicrobial stewardship, Multidrug resistant organisms, Antimicrobials use, Infectious and parasitic diseases, RC109-216
Abstract: Abstract Discontinuation of antimicrobial stewardship programs (ASPs) and increased antibiotic use were described during SARS-CoV-2 pandemic. In order to measure COVID-19 impact on ASPs in a setting of high multidrug resistance organisms (MDRO) prevalence, a qualitative survey was designed. In July 2021, eighteen ID Units were asked to answer a questionnaire about their hospital characteristics, ASPs implementation status before the pandemic and impact of SARS-CoV-2 pandemic on ASPs after the 1st and 2nd pandemic waves in Italy. Nine ID centres (50%) reported a reduction of ASPs and in 7 cases (38.9%) these were suspended. After the early pandemic waves, the proportion of centres that restarted their ASPs was higher among the ID centres where antimicrobial stewardship was formally identified as a priority objective (9/11, 82%, vs 2/7, 28%). SARS-CoV-2 pandemic had a severe impact in ASPs in a region highly affected by COVID-19 and antimicrobial resistance but weaknesses related to the pre-existent ASPs might have played a role.
Published: 2022
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46. Six-month immune responses to mRNA-1273 vaccine in combination antiretroviral therapy treated late presenter people with HIV according to previous SARS-CoV-2 infection

Author: Augello, Matteo, Bono, Valeria, Rovito, Roberta, Tincati, Camilla, d’Arminio Monforte, Antonella, and Marchetti, Giulia
Published: 2023
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47. Associations between integrase strand-transfer inhibitors and cardiovascular disease in people living with HIV: a multicentre prospective study from the RESPOND cohort consortium

Author: Neesgaard, Bastian, Greenberg, Lauren, Miró, Jose M, Grabmeier-Pfistershammer, Katharina, Wandeler, Gilles, Smith, Colette, De Wit, Stéphane, Wit, Ferdinand, Pelchen-Matthews, Annegret, Mussini, Cristina, Castagna, Antonella, Pradier, Christian, d'Arminio Monforte, Antonella, Vehreschild, Jörg J, Sönnerborg, Anders, Anne, Alain V, Carr, Andrew, Bansi-Matharu, Loveleen, Lundgren, Jens D, Garges, Harmony, Rogatto, Felipe, Zangerle, Robert, Günthard, Huldrych F, Rasmussen, Line D, Necsoi, Coca, van der Valk, Marc, Menozzi, Marianna, Muccini, Camilla, Peters, Lars, Mocroft, Amanda, and Ryom, Lene
Published: 2022
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48. Prevalence of Chagas disease and strongyloidiasis among HIV-infected Latin American immigrants in Italy – The CHILI study

Author: Rodari, Paola, Tamarozzi, Francesca, Tais, Stefano, Degani, Monica, Perandin, Francesca, Buonfrate, Dora, Nicastri, Emanuele, Lepore, Luciana, Giancola, Maria Letizia, Carrara, Stefania, Tavelli, Alessandro, Cozzi-Lepri, Alessandro, D'Arminio Monforte, Antonella, Silva, Ronaldo, and Angheben, Andrea
Published: 2022
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49. Remdesivir and three other drugs for hospitalised patients with COVID-19: final results of the WHO Solidarity randomised trial and updated meta-analyses

Author: Pan, Hongchao, Peto, Richard, Henao Restrepo, Ana Maria, Preziosi, Marie-Pierre, Sathiyamoorthy, Vasee, Karim, Quarraisha Abdool, Alejandria, Marissa, Hernàndez García, César, Kieny, Marie-Paule, Malekzadeh, Reza, Murthy, Srinivas, Reddy, K. Srinath, Periago, Mirta Roses, Hanna, Pierre Abi, Abutidze, Akaki, Ader, Florence, Al-Bader, Abdullah, Alhasawi, Almonther, Allum, Emma, Al Mawali, Adhra, Alotaibi, Athari, Alvarez- Moreno, Carlos, Appadoo, Sheila, Arts, Derk, Asiri, Abdullah, Aukrust, Pål, Barratt-Due, Andreas, Genetu Bayih, Abebe, Beaumont, Helena, Bellani, Samir, Benassi, Virginia, Bhargava, Balram, Branca, Mattia, Cappel-Porter, Heike, Cerrato, Nery, Cheick Haidara, Fadima, Chow, Ting Soo, Como, Nadia, Eustace, Joe, Gabunia, Tamar, García, Patricia, Godbole, Sheela, Gotuzzo, Eduardo, Griskevicius, Laimonas, Hamra, Rasha, Hassan, Mariam, Hassany, Mohamed, Hutton, David, Irmansyah, Irmansyah, Jancoriene, Ligita, Khamis, Faryal, Kirwan, Jana, Kumar, Suresh, Lennon, Peter, Lopardo, Gustavo, Lydon, Patrick, Magrini, Nicola, Manevska, Suzana, Manuel, Oriol, McGinty, Sybil, Medina, Marco, Mesa Rubio, Maria Lucia, Miranda Montoya, Maria Consuelo, Nel, Jeremy, Nunes, Estevao, Perola, Markus, Portoles, Antonio, Rasmin, Menaldi, Raza, Aun, Rees, Helen, Reges, Paula, Rogers, Chris, Salami, Kolawole, Salvadori, Marina, Sauermann, Mamatha, Sinani, Narvina, Sow, Samba, Sterne, Jonathan AC, Stevanovikj, Milena, Tacconelli, Evelina, Tavares Maltez, Fernando Manuel, Teferi, Mekonnen, Tikkinen, Kari, Trelle, Sven, Tsertsvadze, Tengiz, Zaid, Hala, Røttingen, John-Arne, Swaminathan, Soumya, Ryan, Michael, Gjermeni, Nevila, Meta, Esmeralda, Aguila, Damian, Alonso, Ignacio, Altamirano, Marcos, Alvarez, María, Alzola, Rodrigo, Arce, Veronica, Arribillaga, Patricia, Avila, Rafael, Balbuena, Juan, Barcelona, Laura, Barletta, José, Benedetti, María, Berdiñas, Verónica, Burgui, Julieta, Caimi, Sabrina, Carrillo, Juan, Carrizo, Juan, Castelli, Juan, Cazaux, Alexis, Cervellino, Flavia, Chalco, Angelo, Chediack, Viviana, Cunto, Eleonora, D'Amico, Nicolàs, de Vedia, Lautaro, Delgado, Carolina, Di Pilla, Debora, Díaz, Miguel, Díaz Aguiar, Pablo, Domínguez, Cecilia, Ellero, Leonor, Farina, Javier, Fernàndez, José, Ferreyra, Roxana, Filippi, María, Fogar, Carolina, Frare, Pablo, Giudiche, Celeste, Golikow, Mariana, Gomez, Maria Georgina, Hermida, Laura, Hurtado, Mariano, Jacobo, Mariela, Jaume, Martin, Laplume, Diego, Lescano, María, Lista, Nicolàs, Loiacono, Flavia, López, Ana Belen, Losso, Marcelo, Luna, Cecilia, Lupo, Sergio, Marianelli, Leonardo, Martin, Anabella, Masciottra, Florencia, Mykietiuk, Analía, Orellano, Lorena, Pachioli, Valeria, Padilla, María José, Pallavicini, Cecilia, Patroso, Jazmin, Perez Blanco, Luz, Presas, Jose Louis, Provenzano, Matias, Lavera, Lorena, Reichert, Viviana, Riveros, Florencia, Rodríguez, Alejandra, Rolon, María José, Salvay, Carolina, Simonetta, María, Sisto, Alicia, Themines, Sandra, Tito, Fernando, Toibaro, Javier, Torales, Graciela, Verón, Luciano, Vizzotti, Carla, Egle, Alexander, Greil, Richard, Joannidis, Michael, Altdorfer, Antoine, Belkhir, Leila, Fraipont, Vincent, Hites, Maya, Arruda, Erico, Breda, Giovanni, Colussi, Arthur, Corradi, Miran, Croda, Julio, Duani, Helena, João, Esaú, Machado, Elizabeth, Mello, Fernanda, Miranda Filho, Demócrito, Monteiro, Poliana, Nunes, Ceuci, Pereira Junior, Luiz Carlos, Pinto, Gustavo, Raboni, Sonia, Ramos, Marcelo, Ruffing, Leonardo, Santos, Valdilea, Souza, Tamara, Medeiros, Melissa, Schwarzbold, Alexandre, Ali, Karim, Azher, Tanweer, Bellemare, David, Binnie, Alexandra, Borgia, Sergio, Cavayas, Yiorgos Alexandros, Chagnon, Nicholas, Cheng, Matthew, Cloutier, Eve, Conly, John, Costiniuk, Cecilia, Daneman, Nick, Douglas, James, Downey, Catarina, Duan, Erick, Durand, Medeline, English, Shane, Farjou, George, Fera, Evadiki, Fontela, Patricia, Fowler, Rob, Fralick, Mike, Gamble, David Gregory, Geagea, Anna, Grant, Jennifer, Harrison, Luke, Havey, Thomas, Hoang, Holly, Kelly, Lauren, Keynan, Yoav, Khwaja, Kosar, Klein, Marina, Kolan, Christophe, Kronfli, Nadine, Lamontagne, Francois, Lee, Nelson, Lee, Todd, Lim, Rachel, Lostun, Alexandra, MacIntyre, Erika, Malhamé, Isabelle, Martin-Carrier, Francois, McGuinty, Marlee, Munan, Matthew, O'Neil, Conar, Ovakim, Daniel, Papenburg, Jesse, Parhar, Ken, Parvathy, SeemaNair, Perez-Patrigeon, Santiago, Rishu, Asgar, Rushton, Moira, Scherr, Kim, Schwartz, Kevin, Semret, Makeda, Silverman, Micahel, Singh, Ameeta, Sligl, Wendy, Smith, Stephanie, Somayaji, Ranjani, Tan, Darrell, Tran, Tuong-Vi, Tremblay, Alain, Tsang, Jennifer, Turgeon, Alexis, Vakil, Erik, Weatherald, Jason, Yansouni, Cedric, Zarychanski, Ryan, Aristizabal, Claudia, Bravo, Juan, Caicedo, Monica, Chacón, Julio, Garzón, Diego, Guevara, Fredy, Lozano-Gonzàlez, Silvia, Macareno, Hugo, Montañez-Ayala, Anita, Oñate, Jose, Rojas-Gambasica, Jose, Rosso, Fernando, Saavedra, Carlos, Valderrama, Sandra, Vàquiro-Herrera, Eliana, Varón-Vega, Fabio, Zuluaga, Ivan, Abdel Baki, Amin, Abdelbary, Akram, Abdel-Razek, Wael, Amin, Wagdi, Asem, Noha, Elassal, Gehan, Elshesheny, Marwa, Fathy, Mohamed, Fathy, Naglaa, Fayed, Notaila, Hammam, Ahmed, Hassany, Sahar, Ibrahim, Hamdy, Kamal, Ehab, Masoud, Hossam, Mohamed, Maryam, Mohamed Gouda, Abdullah, Moustafa, Ehab, Okasha, Shaimaa, Rafik, Ahmed, Said, Ahmed, Sedky, Asmaa, Solyman Kabil, Mohamed, Tarek, Sara, Tharwat, Ahmed, Zaky, Samy, Abegaz, Emawayish Tesema, Bekele, Zelalem Mekonnen, Asfaw, Filmona Mekuria, Tegegne, Netsanet Aragaw, Teklemariam, Miheret Fikre, Nigusse, Frehiwot Tamiru, Achalu, Daniel Legesse, Weldegergs, Shewit Tesfagabr, Huluka, Dawit Kebede, Tereda, Addisu Birhanu, Ala-Kokko, Tero, Delany, Jutta, Ekroos, Heikki, Hankkio, Riina, Haukipää, Mia, Hetemäki, Iivo, Holma, Pia, Holmberg, Ville, Horstia, Saana, Jalkanen, Ville, Jämsänen, Toni, Järventie, Juuso, Järvinen, Petrus, Kalliala, Ilkka, Kauma, Heikki, Kilpeläinen, Tuomas, Kreivi, Hanna-Riikka, Kuitunen, Ilari, Lamminmäki, Satu, Mäkinen, Laura, Mäntylä, Jarkko, Mattila, Tiina, Myllärniemi, Marjukka, Niskanen, Joni, Nykänen, Taina, Nyqvist, Miro, Paajanen, Juuso, Partanen, Terhi, Patovirta, Riitta-Liisa, Paukkeri, Erja-Leena, Puusti, Emmi, Renner, Andreas, Reponen, Emma, Risku, Sari, Rosberg, Tuomas, Rutanen, Jarno, Säilä, Petrus, Salonen, Päivi, Sinisalo, Marjatta, Sivenius, Katariina, Tuominen, Susanna, Aboab, Jerone, Alfaiate, Toni, Andrejak, Claire, Andreu, Pascal, Belhadi, Drifa, Benezit, Francois, Botelho-Nevers, Elisabeth, Bouadma, Lila, Bougon, David, Bouiller, Kevin, Bounes, Fanny, Boyer, Alexandre, Bruel, Cédric, Buffet, Alexandre, Burdet, Charles, Cazanave, Charles, Chabertier, Cyrille, Clere-Jehl, Rapahel, Costagliola, Dominique, Courjon, Johan-Victor, Crockett, Flora, Danion, Francois, Dechanet, Aline, Dellamonica, Jean, Delmas, Christelle, Diallo, Alpha, Djossou, Felix, Dubost, Clement, Dupont, Axelle, Epaulard, Olivier, Faure, Emmmanuel, Faure, Karine, Fayol, Antoine, Figueiredo, Samy, Fougerou, Claire, Gaborit, Benjamin, Gaci, Rostane, Gagneux-Brunon, Amandine, Gallien, Sebastien, Garot, D, Goehringer, Francois, Gruson, Didier, Hinschberger, Olivier, Hulot, Jean-Sebastien, Jaureguiberry, Stephane, Jean-Michel, Vanessa, Kerneis, Solen, Kimmoun, Antoine, Klouche, Kada, Lachatre, Marie, Lacombe, Karine, Laine, Fabrice, Lanoix, Jean Philippe, Laribi, Samira, Launay, Odile, Laviolle, Bruno, Le Moing, Vincent, Le Pavec, Jerome, Lebeaux, David, Leroy, Sylvie, Lescure, Xavier, Livrozet, Marine, Makinson, Alain, Malvy, Denis, Marquette, Charles-Hugo, Martin-Blondel, Guillaume, Mayaux, Julien, Mekontso Dessap, Armand, Mentre, France, Mercier, Noemie, Meziani, Ferhat, Molina, Jean Michel, Mootien, Yoganaden, Mourvillier, Bruno, Navellou, Jean Christoph, Noret, M, Peiffer- Smadja, Nathan, Peytavin, Gilles, Pialoux, Gilles, Pilmis, Benoît, Piroth, Lionel, Poindron, Vincent, Poissy, Julien, Pourcher, Valerie, Quenot, Jean Pierre, Raffi, Francois, Reignier, Jean, Richard, Jean Christoph, Robert, Céline, Saillard, Juliette, Sayre, Naomi, Senneville, Eric, Stefan, Francois, Tellier, Marie Capucine, Terzi, Nicolas, Textoris, Julien, Thiery, Guillame, Timsit, Jean Francois, Tolsma, Violaine, Tubiana, Sarah, Wallet, Florent, Yazdanpanah, Yazdan, Zerbib, Yoann, Aguilar, Carlos, Erazo, Laura, Fiallos, Angel, Figueroa, Rosbinda, Flores, Juan Jose, Melendez, Lesddyy, Moncada, Wendy, Abraham, Ooriapadickal Cherian, Acharya, Chetankumar, Aedula, Vinaya Sekhar, Aggarwal, Richa, Agrawal, Nishant, Agrawal, Umang, Agrawal, Abhishekh, Ahmad, Mohammad, Atal, Shubham, Babu, Avinash, Baidya, Dalim Kumar, Balachandran, Amith, Bangar, Rakhee, Bhadade, Rakesh, Bhandari, Sudhir, Bhapal, Meghavi, Bhardwaj, Pankaj, Bhati, Gaurav, Bhatia, Pradeep, Bhatt, Krishnakant, Bingi, Thrilok Chander, Borse, Rohidas, Buch, Vyom, Chand, Dipti, Chandwani, Ashish, Charan, Jaykaran, Chaudhari, Mayur, Chaudhari, Kirti, Chaudhary, Vipul, Chauhan, Nishant, Chikara, Gaurav, Daswani, Bharti, de Souza, Rosemarie, Desai, Chetna, Divakar, Balusamy, Divhare, Sujeet, Dorairajan, Suresh Kumar, Dutt, Naveen, Ethirajan, Therani Rajan, Gamit, Amit, Gamit, Sweta, Garg, Mahendra, Goenka, Ajay, Goenka, Aniket, Guleria, Randeep, Gupta, Paras, Gupta, Nivedita, Gupta, Madhur, Harde, Minal, Ingle, Vaibhav, Iyer, Shivkumar, Jamalapuram, Vaishnavi, Jayanthi, Rangarajan, Joshi, Rajnish, Kadam, Abhijeet, Kalakuntla, Hemanth, Kalikar, Mrunalini, Kalme, Sayali, Kamble, Suchit, Kant, Ravi, Kantharia, Bansari, Kashikar, Arundhati, Kavishvar, Abhay, Kayina, Choro Athipro, Kerkar, Pranali, Khadanga, Sagar, Khandare, Sagar, Kokate, Pranjali, Komathi, Jayavelu, Krishnan, Vijay, Krishnan, Jayasree, Krishnan, Sumitra, Kulur Mukhyaprana, Sudha, Kumarasamy, N, Mahavar, Sunil, Maitra, Souvik, Majumdar, Falguni, Malhotra, Supriya, Mamulwar, Megha, Malini, Padma, Marwah, Vikas, Maurya, Akhilesh, Mehta, Kedar, Mesipogu, Rajarao, Misra, Shobha, Mitra, Sajal, Mittal, Ankit, Mohan, Bharathi, Momin, Mohmmedirfan, Nag, Vijaya, Nagarajan, Ramakrishnan, Nagmani, Kammili, Narlawar, Uday, Natarajan, Gopalakrishnan, Nischal, Neeraj, Ogale, Dhananjay, Palat, Paltial, Panda, Prasan, Panda, Samiran, Pandya, Amee, Parate, Rohit, Paritekar, Arunita, Patel, Parvati, 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Published: 2022
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50. Predictors for choosing doravirine‐based versus INSTI‐based regimen in ART‐naïve and ART‐experienced people with HIV in real‐world setting: Data from the Icona cohort.

Author: d'Arminio Monforte, Antonella, Tavelli, Alessandro, Quiros‐Roldan, Eugenia, Fabbiani, Massimiliano, Ferrara, Micol, Lo Caputo, Sergio, Squillace, Nicola, Rusconi, Stefano, Ponzano, Marta, Bovis, Francesca, Antinori, Andrea, Saracino, Annalisa, and Cozzi‐Lepri, Alessandro
Subjects: *GLOMERULAR filtration rate, *BIOMARKERS, *BODY mass index, *ASPARTATE aminotransferase, *INTEGRASE inhibitors
Abstract: Rationale Methods Results Conclusions Doravirine (DOR) is an attractive new option both for ART‐naïve people with HIV (PWH) and those with suppressed HIV‐RNA who seek treatment simplification. We used real‐world data to examine the pattern of use of DOR‐containing regimens in these settings.All PWH enrolled in the Icona cohort after January 2020 who initiated a three‐drug regimen (3‐DR) with DOR or an integrase inhibitor (INSTI)‐based regimen as first antiretroviral therapy (ART) or when switching ART, with HIV‐RNA ≤50 copies/mL, were included. We used univariate and multivariable logistic regression models to identify demographic factors, immuno‐virological and laboratory markers associated with the prescription of 3‐DR DOR instead of INSTI‐based regimens.A total of 5803 PWH were included; 1958 were in the first regimen (80 DOR, 1,878 INSTI) and 3854 (387 DOR, 3,458 INSTI) were ART‐experienced virologically suppressed. In the first line, 3‐DR DOR was more frequently started in people who inject drugs, and its use was also associated with higher body mass index, higher low‐density lipoprotein levels, and less advanced HIV disease compared with PWH initiating an INSTI‐based regimen. In the switch setting, older age, Italian origin, higher estimated glomerular filtration rate and aspartate aminotransferase levels were all strongly associated with 3‐DR DOR use, as well as higher a CD4/CD8 ratio (only vs. 3‐DR INSTI), while the association with lipid abnormalities was attenuated.Our analysis shows that among PWH in care in Italy, those with less advanced HIV disease but with other fragilities and potential risk factors for comorbidities are more likely to use DOR‐ than INSTI‐based regimens, regardless of prior treatment history. [ABSTRACT FROM AUTHOR]
Published: 2024
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