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The article discusses a patent issued to AmiLyfe LLC for materials and methods aimed at inhibiting tumor growth. The patent focuses on the use of specific amino acids to develop compositions that can potentially inhibit cancer cell growth and proliferation. The inventors highlight the importance of early cancer detection and the challenges associated with current treatment modalities like chemotherapy and radiation therapy. The patent aims to develop novel and effective therapies for cancer treatment that are cost-effective and improve patient tolerance. [Extracted from the article]

A recent study conducted by researchers at the University of Massachusetts Chan Medical School focused on malaria and the challenges posed by deletions of the pfhrp2 and pfhrp3 genes in Plasmodium falciparum parasites, which can render them undetectable by rapid diagnostic tests. The study analyzed over 19,000 whole-genome-sequenced P. falciparum field samples to better understand these deletions, revealing different patterns of deletions and translocations driven by interchromosomal segmental duplications. The research suggests that specific conditions are required for the emergence and spread of these deletions, which can inform surveillance strategies for malaria. [Extracted from the article]

A recent study conducted by researchers at the University of Buea focused on malaria in Cameroon, specifically examining false-negative rapid diagnostic tests (RDTs) due to the non-detection of Plasmodium falciparum histidine-rich protein 2/3 (Pfhrp2/3) and gene deletions. The study found that Plasmodium falciparum is the most dominant species across different transmission and ecological zones in Cameroon. While the low prevalence of gene deletions supports the continued use of HRP2-based RDTs for routine malaria diagnosis, the high proportion of false-negatives due to gene-deleted parasites highlights the need for ongoing surveillance to inform control and elimination efforts. [Extracted from the article]

A patent application titled "Enhanced Expression Of An Aromatic Amino Acid Decarboxylase (Aadc) In The Substantia Nigra For The Treatment Of Parkinson's Disease" has been published online. The inventors propose methods and compositions for treating Parkinson's disease by enhancing the expression of AADC in the substantia nigra. This can be achieved by administering an agent, such as a nucleic acid or vector, that increases the expression of AADC. The patent application also mentions the use of levodopa and carbidopa in conjunction with the treatment. [Extracted from the article]

Researchers from Shaanxi University of Chinese Medicine have developed a new method for selectively detecting and quantifying the amino acid histidine (His) and its related metabolites. Histidine plays a crucial role in various physiological processes, and imbalances in its levels can lead to diseases. The researchers designed and synthesized a DMSO-assisted iridium(iii) complex that acts as a luminescent "turn-on" sensor for detecting histidine. The complex demonstrated good sensitivity, selectivity, and anti-interference capabilities, making it a promising tool for future molecular recognition sensing platforms. The research has been peer-reviewed and published in Analytical Methods. [Extracted from the article]

A new report from the Technical University of Denmark (DTU) explores the encapsulation and oxidative stability of vitamin A palmitate within electrosprayed core-shell microcapsules. The study investigates the antioxidant efficacy of various amino acids added to the core of the microcapsules. The research found that histidine was the most efficient amino acid in enhancing the oxidative stability of the vitamin, while lysine showed the lowest protection. The study suggests that the enhancement of oxidative stability is due to hydrophobic interactions and the adsorption of the vitamin on the surface of amino acid crystals. [Extracted from the article]

A study conducted by Xuzhou Medical University in Jiangsu, China, investigated the effects of electroacupuncture (EA) treatment on Parkinson's disease (PD). The study used a PD mouse model and found that EA treatment improved motor dysfunction and restored neuronal function. It was also observed that EA treatment inhibited the enrichment of pro-inflammatory cytokines and suppressed neuronal pyroptosis. The study concluded that EA treatment promotes METTL9 histidine methylation of NF-kappa B/NLRP3 signaling, leading to the improvement of PD symptoms. [Extracted from the article]

A groundbreaking study led by Sarah Worthan, Ph.D., at Vanderbilt University has successfully evolved microbial cultures with the ability to sense pH changes, which is crucial for responding to environmental fluctuations. This discovery has also led to the identification of similar mutations in nature in emerging pathogens and coral symbionts, organisms that face challenging pH shifts in their environments. The study found that a mutation in the Rho protein, involving the replacement of an arginine amino acid with a histidine, allows bacteria to sense pH and rapidly impact gene expression. The research highlights the power of lab-driven evolution and has implications for understanding how organisms adapt to changing pH conditions. [Extracted from the article]

A patent application titled "Anti-Connexin Antibody Formulations" has been published online. The application discusses the challenges associated with stabilizing antibodies for transport and storage, and proposes a pharmaceutical formulation for anti-Cx43 antibodies. The formulation includes an anti-Cx43 antibody, a buffer, a surfactant, and a stabilizer, with a pH between 5 and 6. The patent application also provides information on the amino acid sequences of the antibody and the epitope it binds to. The formulation is intended for inhibiting the opening of Cx43 hemichannels in cells, potentially for treating inflammatory or neurodegenerative diseases. [Extracted from the article]

A recent study conducted by researchers at Novartis explores the effects of alternative buffer systems on the stability of biopharmaceutical drugs. The researchers found that conventional buffers like histidine and phosphate may not always be the best choice for all monoclonal antibodies (mAbs). They investigated the effects of various alternative buffer systems on seven different mAbs and found that certain buffers, such as arginine/citrate, were effective in preserving protein stability. The study suggests that the development of biopharmaceutical formulations should consider alternative buffer systems, as they may offer comparable or even superior performance. [Extracted from the article]

This article discusses the impact of culturing bacteria on rich media, which can lead to the loss of intrinsic metabolic traits and the accumulation of unnoticed mutations. The study focuses on Klebsiella pneumoniae and identifies two sub-populations within a frozen stock that differ in their ability to grow without L-histidine. The researchers used microbiological culture, whole genome sequencing, and metabolic modeling to investigate these auxotrophs. The study highlights the prevalence of such auxotrophies in public genome collections and emphasizes the need to consider the effects of rich-media culturing on wild type domestication. [Extracted from the article]

A recent preprint abstract discusses the deletion of the pfhrp2 and pfhrp3 genes in Plasmodium falciparum, the parasite that causes malaria. These deletions can make the parasites undetectable by malaria rapid diagnostic tests (RDTs). The study analyzed over 19,000 P. falciparum field samples and found that pfhrp2 deletion occurred through chromosomal breakage and subsequent telomere healing, while pfhrp3 deletions involved loss from pfhrp3 to the telomere and showed different patterns. The researchers also identified a hybrid chromosome with long-read sequencing, suggesting a translocation product arising from recombination between large interchromosomal ribosome-containing segmental duplications. The findings provide insights into the emergence and spread of pfhrp3 deletions and can help refine surveillance strategies for malaria. [Extracted from the article]

Regeneron Pharmaceuticals Inc. has been issued a patent for anti-VEGF protein compositions and methods for producing them. These protein-based biopharmaceutical compositions are used in the treatment of ophthalmological diseases, cancer, autoimmune disease, and infection. The patent describes the production of aflibercept, a fusion protein, using chemically defined media (CDM) and soy hydrolysate medium. The invention also includes methods for preparing a prefilled syringe containing aflibercept, which can be used to treat various eye disorders associated with pathological angiogenesis. [Extracted from the article]

Regeneron Pharmaceuticals Inc. has been issued a patent for stabilized formulations containing anti-interleukin-6 receptor (IL-6R) antibodies. These antibodies are used in the treatment and prevention of diseases such as rheumatoid arthritis. The patent describes the formulation of the antibodies, which includes amino acids, carbohydrates, and a non-ionic surfactant. The formulations are designed to maintain the stability of the antibodies during storage and have a suitable viscosity for administration to patients. The patent also includes claims for a pen delivery device containing the stable liquid pharmaceutical formulation. [Extracted from the article]

A recent report discusses research on sepsis conducted by a researcher at Kyushu University in Fukuoka, Japan. The study focused on the association between histidine-rich glycoprotein (HRG) concentrations and critical conditions such as septic shock, disseminated intravascular coagulation (DIC), and acute respiratory distress syndrome (ARDS). Blood samples were collected from 53 critically ill patients, and it was found that HRG levels were significantly reduced in patients with septic shock and DIC but not in those with ARDS. Decreased HRG levels were also associated with higher mortality rates. The study suggests that HRG could be a potential intervention for sepsis patients, but further research is needed to explore its therapeutic potential. [Extracted from the article]

Researchers at Addis Ababa University conducted a study to explore the genetic diversity of Plasmodium falciparum histidine-rich protein 2/3 (PfHRP2/3) in malaria cases in Ethiopia. They collected blood samples from three health centers and analyzed the DNA using molecular techniques. The study found small variations in the frequency and number of amino acid repeat types in PfHRP2/3 across the health centers. The researchers concluded that there is significant diversity in PfHRP2/3 among clinical isolates of Plasmodium falciparum in Ethiopia, highlighting the need for monitoring the efficacy of PfHRP2-based rapid diagnostic tests. [Extracted from the article]

A patent application has been submitted for the approval of formulations of anti-PD1 antibodies. PD-1 is a cell surface protein that regulates immune responses, and inhibiting its interaction with PD-L1 can enhance T cell responses and mediate antitumor activity. Several antibodies targeting PD-1 have been developed, including pembrolizumab and nivolumab. The patent application describes liquid pharmaceutical compositions containing an anti-PD1 antibody, amino acids, a non-ionic surfactant, and citrate buffer, with a pH between 5.0 and 5.8. These compositions may be used for the treatment of various cancers. [Extracted from the article]

A study conducted at Ain Shams University in Cairo, Egypt compared the effectiveness of two cardioplegia methods, histidine-tryptophan-ketoglutarate (HTK) cardioplegia and cold blood cardioplegia (CBC), in patients undergoing surgical repair for tetralogy of Fallot. The study found that the HTK group showed a significant reduction in vasoactive inotropic score and lower lactate levels compared to the CBC group. Additionally, postoperative echocardiographic assessments showed better right ventricular function in the HTK group. The researchers concluded that HTK cardioplegia may offer better cardiac protection and recovery for patients undergoing tetralogy of Fallot repair. [Extracted from the article]

The article reports on a study from Harbin Medical University that examines the relationship between dietary amino acids glycine and histidine and their effects on hyperlipidemia and hypertension. Topics discussed include the nutritional roles of these amino acids, their antioxidant and anti-inflammatory properties, and the findings of a significant inverse association between high dietary intake of glycine and histidine and the prevalence of these health conditions.

A recent study conducted at Brigham and Women's Hospital has shed light on the role of membrane proteins in the production of outer membrane vesicles (OMVs) in Gram-negative bacteria. The researchers found that the outer membrane protein PagC plays a crucial role in OMV production through pH-dependent interactions with lipopolysaccharide (LPS). Specifically, a pH-sensitive amino acid motif in PagC, containing histidine residues, was found to be essential for OMV formation. These findings provide insights into the mechanisms by which bacteria sense and respond to environmental pH and control membrane dynamics through outer membrane proteins. [Extracted from the article]

A study conducted by researchers at the University of Hawaii at Manoa has provided new insights into Burkholderia pseudomallei, the bacterium that causes the tropical disease melioidosis. The study identified a transcriptional regulator called BP1026B_II1561 that plays a role in the pathogenesis of the bacterium. The regulator controls secondary metabolite biosynthesis, fatty acid degradation, and propanoate metabolism, as well as the expression of an outer membrane porin and genes in the shikimate biosynthetic pathway. The study suggests that these pathways could be potential targets for therapeutic intervention against melioidosis. [Extracted from the article]

A recent study conducted by the Russian Academy of Sciences has explored the potential of synthetic antimicrobial peptides (SAMPs) as antifungal agents. The researchers synthesized a series of histidine-containing SAMPs with a "linear" type of amphipathicity and compared their antifungal activity to that of a natural antifungal peptide. The results showed that the histidine-containing SAMPs exhibited increased antifungal activity with an increase in the number of histidine residues. The peptide H10, which had the highest antifungal activity and low hemolytic toxicity, was identified as a promising antifungal peptide drug. [Extracted from the article]

The article focuses on a patent application for the acute and rapid treatment of headaches, such as migraines, using anti-CGRP antibodies. Topics include the role of Calcitonin Gene Related Peptide (CGRP) in migraine development, the use of CGRP-targeting antibodies for treatment, and the advancement of these therapies compared to existing treatments.

The article highlights research from the Department of Chemical and Process Engineering at Midlands State University, Zimbabwe, focusing on a histidine-functionalised polypyrrole nanocomposite for effectively removing toxic hexavalent chromium from water. It demonstrates that the nanocomposite exhibits high adsorption capacity and excellent recyclability, making it suitable for large-scale water purification.

A patent has been issued to the University of California for compositions and methods related to ordered and continuous complementary DNA (cDNA) synthesis across non-continuous templates. The invention addresses the challenge of converting RNA to cDNA for various research and clinical applications, such as nucleic acid hybridization and high-throughput sequencing. The patent describes an isolated eukaryotic non-long terminal repeat reverse transcriptase (non-LTR RT) protein with specific characteristics, including a truncated N-terminal region and a mutation that abolishes endonuclease function. The protein is derived from the Bombyx mori arthropod. The patent also includes claims related to the protein's structure and additional components, such as stabilizer proteins and purification tags. [Extracted from the article]

A recent report from Washington University discusses the study of plant proteins known as phytochromes. Phytochromes are proteins that detect light and undergo a conformational change between dark-adapted and photoactivated states. The researchers used high-resolution cryo-EM maps to build models of these proteins and found that light absorption leads to a cascade of conformational changes that accelerate signaling by phytochrome kinases. This research provides insights into how plants respond to light and may have implications for understanding plant growth and development. [Extracted from the article]

The article provides information on a patent issued for anti-vascular endothelial cell growth factor (anti-VEGF) protein compositions and methods for producing the same, filed by the inventors including Thomas Daly, Ning Li, and Nisha Palackal on July 6, 2022 and published online on August 6, 2024. It mentions the assignee for the patent application, quote from the background information supplied by the inventors, and claims supplied by the inventors.

A study conducted in Bouake, Cote d'Ivoire aimed to estimate the prevalence of asymptomatic and subpatent Plasmodium falciparum infections and investigate potential gene deletions. The study found that 97.2% of individuals were asymptomatic, and the prevalence of P. falciparum infection was higher in school-age children compared to younger and older age groups. The study also found that light microscopy and rapid diagnostic tests were reliable only at high parasite densities. No gene deletions were observed. The high prevalence of asymptomatic and subpatent infections highlights the need for targeted strategies to reduce malaria in urban Cote d'Ivoire. [Extracted from the article]

A recent study conducted at the William S. Middleton Memorial Veterans Hospital in Madison, Wisconsin, has found that reducing dietary levels of the amino acid histidine can lead to weight loss and improved metabolic health in male mice. The researchers observed that reducing histidine intake by 67% resulted in decreased weight gain, reduced adipose and lean mass, and increased insulin sensitivity in the mice. These findings suggest that reducing histidine intake may be a potential treatment for obesity in humans. The study also found that variation in dietary histidine levels may help explain differences in body mass index among humans. [Extracted from the article]

A study conducted at Yan'an University in Shaanxi, China, has developed a smart two-dimensional photonic hydrogel sensor for detecting the amino acid histidine. The sensor, called CD-2DPCH, was created by modifying a hydrogel with NH2-beta-cyclodextrin and polystyrene two-dimensional photonic crystal array. The sensor demonstrated a good linear correlation in detecting histidine concentrations ranging from 0.1 to 1 and 10 to 400 μM, with a limit of detection of 58 nM. The researchers believe this sensor could be used to detect other amino acids by modifying different recognition groups. [Extracted from the article]

A patent application has been made available online for pharmaceutical compositions containing bispecific anti-CD37 antibodies. These antibodies target a protein called CD37, which is found on B cells and certain cancer cells. The patent application describes the development of stable formulations of these antibodies that have enhanced effectiveness and interaction with the target. The compositions include specific sequences of antibodies, as well as other ingredients such as a buffer, sugar or polyol, and polysorbate 80. The patent application also covers methods of using these compositions for the treatment of cancer, specifically B-cell malignancies like non-Hodgkin lymphoma and chronic lymphocytic leukemia. [Extracted from the article]

A new report from the University of Puerto Rico explores the relationship between branched-chain and aromatic amino acids (BCAAs/AAAs) and type 2 diabetes (T2D) in Puerto Rican adults. The study found that higher levels of BCAAs were associated with a higher risk of prevalent and incident T2D, as well as increases in measures of glycemia, dyslipidemia, and obesity. Additionally, the amino acid tyrosine was identified as a significant predictor of incident T2D and worsening insulin resistance over time. These findings suggest that BCAAs and tyrosine could serve as early markers of future glycemic changes in Puerto Ricans. [Extracted from the article]

The article focuses on the recent issuance of a patent for pharmaceutical formulations containing IL-6 antagonists, specifically designed to modulate IL-6 cytokines and treat various disorders. It states that the patent, assigned to F. Hoffmann-La Roche Inc., details specific formulations of IL-6 antibodies and their potential therapeutic uses, particularly in treating diseases associated with IL-6.

According to a preprint abstract from biorxiv.org, researchers have discovered that the VanS sensor histidine kinase from type-B vancomycin-resistant enterococci (VRE) is able to directly recognize vancomycin, an antibiotic commonly used to treat infections. The VanS protein plays a crucial role in antibiotic resistance by detecting vancomycin and transmitting this signal to the VanR transcription factor. This finding represents the first confirmation of a direct sensing mechanism for any VanS protein. The research has not yet undergone peer review. [Extracted from the article]

A new report discusses research findings on amino acids, specifically focusing on the peptide/histidine transporter PHT1 (SLC15A4). This transporter is found in the lysosomal membranes of immune cells and plays a role in metabolic and inflammatory signaling. The research presents a novel transport assay based on solid-supported membrane-based electrophysiology (SSME) to study PHT1 in its native lysosomal environment. The findings include the first recordings of electrophysiological properties, a pH dependence analysis, substrate selectivity, and transport kinetics. This new assay is expected to contribute to the understanding of PHT1's functional properties and its pharmacological potential. [Extracted from the article]

A patent has been issued to Nanyang Technological University for peptide coacervates derived from histidine-rich proteins, which can be used for the efficient delivery of active agents. These peptide coacervates have the potential to be used in the management and treatment of diseases such as cancer and diabetes. The coacervates can encapsulate multiple active agents and can be designed to respond to specific conditions or stimuli. This patent provides guidelines for designing peptides with liquid-liquid phase separation ability for various applications, including smart drug-delivery systems. [Extracted from the article]