42 results on '"Carella, Maria"'
Search Results
2. Assessment and management of heart failure in patients with chronic kidney disease
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Guaricci, Andrea Igoren, Sturdà, Francesca, Russo, Roberto, Basile, Paolo, Baggiano, Andrea, Mushtaq, Saima, Fusini, Laura, Fazzari, Fabio, Bertandino, Fulvio, Monitillo, Francesco, Carella, Maria Cristina, Simonini, Marco, Pontone, Gianluca, Ciccone, Marco Matteo, Grandaliano, Giuseppe, Vezzoli, Giuseppe, and Pesce, Francesco
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- 2024
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3. Heart Failure and Erectile Dysfunction: a Review of the Current Evidence and Clinical Implications
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Carella, Maria Cristina, Forleo, Cinzia, Stanca, Alessandro, Carulli, Eugenio, Basile, Paolo, Carbonara, Umberto, Amati, Fabio, Mushtaq, Saima, Baggiano, Andrea, Pontone, Gianluca, Ciccone, Marco Matteo, and Guaricci, Andrea Igoren
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- 2023
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4. Cardiomyopathies and Psychiatric Disorders: An Overview and General Clinical Recommendations
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Stanca, Alessandro, Carella, Maria Cristina, Basile, Paolo, Forleo, Cinzia, Ciccone, Marco Matteo, and Guaricci, Andrea Igoren
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- 2024
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5. Cardiac magnetic resonance reveals concealed structural heart disease in patients with frequent premature ventricular contractions and normal echocardiography: A systematic review
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Basile, Paolo, Soldato, Nicolò, Pedio, Erika, Siena, Paola, Carella, Maria Cristina, Dentamaro, Ilaria, Khan, Yamna, Baggiano, Andrea, Mushtaq, Saima, Forleo, Cinzia, Ciccone, Marco Matteo, Pontone, Gianluca, and Guaricci, Andrea Igoren
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- 2024
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6. ECG/echo indexes in the diagnostic approach to amyloid cardiomyopathy: A head-to-head comparison from the AC-TIVE study
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Longo, Francesca, Rossi, Maddalena, Varrà, Guerino Giuseppe, Saro, Riccardo, Dore, Franca, Girardi, Francesca, Vergaro, Giuseppe, Musumeci, Beatrice, Autore, Camillo, Cappelli, Francesco, Perfetto, Federico, Olivotto, Iacopo, Favale, Stefano, Carella, Maria Cristina, Guaricci, Andrea Igoren, Ciccone, Marco Matteo, Di Bella, Gianluca, Tomasoni, Daniela, Rella, Valeria, Branzi, Giovanna, Badano, Luigi, Parati, Gianfranco, Palmiero, Giuseppe, Caiazza, Martina, Caponetti, Angelo Giuseppe, Saturi, Giulia, Labate, Marianna Eleonora, Andreis, Alessandro, Paneva, Elena, De Ferrari, Gaetano Maria, Di Ienno, Luca, De Carli, Giuseppe, Giacomin, Elisa, Arzilli, Chiara, Pagura, Linda, Porcari, Aldostefano, Cameli, Matteo, Biagini, Elena, Canepa, Marco, Crotti, Lia, Imazio, Massimo, Forleo, Cinzia, Pavasini, Rita, Limongelli, Giuseppe, Perlini, Stefano, Metra, Marco, Boriani, Giuseppe, Emdin, Michele, Sinagra, Gianfranco, and Merlo, Marco
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- 2024
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7. Comparative effectiveness of Cangrelor in patients with acute coronary syndrome undergoing percutaneous coronary intervention: an observational investigation from the M.O.Ca. registry
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Pepe, Martino, Carulli, Eugenio, Larosa, Claudio, Napoli, Gianluigi, Nestola, Palma Luisa, Carella, Maria Cristina, Giordano, Salvatore, Tritto, Rocco, Bartolomucci, Francesco, Cirillo, Plinio, Zoccai, Giuseppe Biondi, Giordano, Arturo, and Ciccone, Marco Matteo
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- 2023
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8. Modelling geographical variations in fertility and population density of Italian and foreign populations at the local scale: a spatial Durbin approach for Italy (2002–2018)
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Benassi, Federico and Carella, Maria
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- 2023
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9. Non-intact Families and Children’s Educational Outcomes: Comparing Native and Migrant Pupils
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Guetto, Raffaele, Zanasi, Francesca, and Carella, Maria
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- 2022
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10. Subjective Well-Being, Transnational Families and Social Integration of Married Immigrants in Italy
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Carella, Maria, García-Pereiro, Thaís, and Pace, Roberta
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- 2022
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11. Beyond Stress Ischemia: Unveiling the Multifaceted Nature of Coronary Vulnerable Plaques Using Cardiac Computed Tomography.
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Napoli, Gianluigi, Mushtaq, Saima, Basile, Paolo, Carella, Maria Cristina, De Feo, Daniele, Latorre, Michele Davide, Baggiano, Andrea, Ciccone, Marco Matteo, Pontone, Gianluca, and Guaricci, Andrea Igoren
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CORONARY artery calcification ,EPICARDIAL adipose tissue ,PROGNOSIS ,COMPUTED tomography ,CARDIOVASCULAR diseases risk factors ,ATHEROSCLEROTIC plaque - Abstract
Historically, cardiovascular prevention has been predominantly focused on stress-induced ischemia, but recent trials have challenged this paradigm, highlighting the emerging role of vulnerable, non-flow-limiting coronary plaques, leading to a shift towards integrating plaque morphology with functional data into risk prediction models. Coronary computed tomography angiography (CCTA) represents a high-resolution, low-risk, and largely available non-invasive modality for the precise delineation of plaque composition, morphology, and inflammatory activity, further enhancing our ability to stratify high-risk plaque and predict adverse cardiovascular outcomes. Coronary artery calcium (CAC) scoring, derived from CCTA, has emerged as a promising tool for predicting future cardiovascular events in asymptomatic individuals, demonstrating incremental prognostic value beyond traditional cardiovascular risk factors in terms of myocardial infarction, stroke, and all-cause mortality. Additionally, CCTA-derived information on adverse plaque characteristics, geometric characteristics, and hemodynamic forces provides valuable insights into plaque vulnerability and seems promising in guiding revascularization strategies. Additionally, non-invasive assessments of epicardial and pericoronary adipose tissue (PCAT) further refine risk stratification, adding prognostic significance to coronary artery disease (CAD), correlating with plaque development, vulnerability, and rupture. Moreover, CT imaging not only aids in risk stratification but is now emerging as a screening tool able to monitor CAD progression and treatment efficacy over time. Thus, the integration of CAC scoring and PCAT evaluation into risk stratification algorithms, as well as the identification of high-risk plaque morphology and adverse geometric and hemodynamic characteristics, holds promising results for guiding personalized preventive interventions, helping physicians in identifying high-risk individuals earlier, tailoring lifestyle and pharmacological interventions, and improving clinical outcomes in their patients. [ABSTRACT FROM AUTHOR]
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- 2024
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12. Abstract 15052: A Young Patient Who Presented With Dilated Cardiomyopathy and Renal Infarction During Treatment With Isotretinoin
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Napoli, Gianluigi, De Feo, Daniele, Carella, Maria Cristina, Forleo, Cinzia, Favale, Stefano, and Pepe, Martino
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- 2022
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13. Missense and Non-Missense Lamin A/C Gene Mutations Are Similarly Associated with Major Arrhythmic Cardiac Events: A 20-Year Single-Centre Experience.
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Forleo, Cinzia, Carella, Maria Cristina, Basile, Paolo, Carulli, Eugenio, Dadamo, Michele Luca, Amati, Francesca, Loizzi, Francesco, Sorrentino, Sandro, Dentamaro, Ilaria, Dicorato, Marco Maria, Ricci, Stefano, Bagnulo, Rosanna, Iacoviello, Matteo, Santobuono, Vincenzo Ezio, Caiati, Carlo, Pepe, Martino, Desaphy, Jean-Francois, Ciccone, Marco Matteo, Resta, Nicoletta, and Guaricci, Andrea Igoren
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GENETIC mutation ,FRAMESHIFT mutation ,MAJOR adverse cardiovascular events ,MISSENSE mutation ,CARDIAC arrest ,BRUGADA syndrome ,ARRHYTHMIA - Abstract
Arrhythmic risk stratification in patients with Lamin A/C gene (LMNA)-related cardiomyopathy influences clinical decisions. An implantable cardioverter defibrillator (ICD) should be considered in patients with an estimated 5-year risk of malignant ventricular arrhythmia (MVA) of ≥10%. The risk prediction score for MVA includes non-missense LMNA mutations, despite their role as an established risk factor for sudden cardiac death (SCD) has been questioned in several studies. The purpose of this study is to investigate cardiac features and find gene–phenotype correlations that would contribute to the evidence on the prognostic implications of non-missense vs. missense mutations in a cohort of LMNA mutant patients. An observational, prospective study was conducted in which 54 patients positive for a Lamin A/C mutation were enrolled, and 20 probands (37%) were included. The median age at first clinical manifestation was 41 (IQR 19) years. The median follow-up was 8 years (IQR 8). The type of LMNA gene mutation was distributed as follows: missense in 26 patients (48%), non-frameshift insertions in 16 (30%), frameshift deletions in 5 (9%), and nonsense in 7 (13%). Among the missense mutation carriers, two (8%) died and four (15%) were admitted onto the heart transplant list or underwent transplantation, with a major adverse cardiovascular event (MACE) rate of 35%. No statistically significant differences in MACE prevalence were identified according to the missense and non-missense mutation groups (p value = 0.847). Our data shift the spotlight on this considerable topic and could suggest that some missense mutations may deserve attention regarding SCD risk stratification in real-world clinical settings. [ABSTRACT FROM AUTHOR]
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- 2024
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14. The Role of Magnetic Resonance Imaging in Cardiomyopathies in the Light of New Guidelines: A Focus on Tissue Mapping.
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Forleo, Cinzia, Carella, Maria Cristina, Basile, Paolo, Mandunzio, Donato, Greco, Giulia, Napoli, Gianluigi, Carulli, Eugenio, Dicorato, Marco Maria, Dentamaro, Ilaria, Santobuono, Vincenzo Ezio, Memeo, Riccardo, Latorre, Michele Davide, Baggiano, Andrea, Mushtaq, Saima, Ciccone, Marco Matteo, Pontone, Gianluca, and Guaricci, Andrea Igoren
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MAGNETIC resonance imaging , *CARDIAC magnetic resonance imaging , *CARDIOMYOPATHIES , *MYOCARDIUM , *CONGENITAL heart disease - Abstract
Cardiomyopathies (CMPs) are a group of myocardial disorders that are characterized by structural and functional abnormalities of the heart muscle. These abnormalities occur in the absence of coronary artery disease (CAD), hypertension, valvular disease, and congenital heart disease. CMPs are an increasingly important topic in the field of cardiovascular diseases due to the complexity of their diagnosis and management. In 2023, the ESC guidelines on cardiomyopathies were first published, marking significant progress in the field. The growth of techniques such as cardiac magnetic resonance imaging (CMR) and genetics has been fueled by the development of multimodal imaging approaches. For the diagnosis of CMPs, a multimodal imaging approach, including CMR, is recommended. CMR has become the standard for non-invasive analysis of cardiac morphology and myocardial function. This document provides an overview of the role of CMR in CMPs, with a focus on tissue mapping. CMR enables the characterization of myocardial tissues and the assessment of cardiac functions. CMR sequences and techniques, such as late gadolinium enhancement (LGE) and parametric mapping, provide detailed information on tissue composition, fibrosis, edema, and myocardial perfusion. These techniques offer valuable insights for early diagnosis, prognostic evaluation, and therapeutic guidance of CMPs. The use of quantitative CMR markers enables personalized treatment plans, improving overall patient outcomes. This review aims to serve as a guide for the use of these new tools in clinical practice. [ABSTRACT FROM AUTHOR]
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- 2024
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15. The Beneficial Role of Telemedicine for Arrhythmic Risk Stratification in Asymptomatic Brugada Syndrome: An Exemplary Case Report.
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Santobuono, Vincenzo Ezio, Carella, Maria Cristina, Guaricci, Andrea Igoren, Carulli, Eugenio, Basile, Paolo, Dicorato, Marco Maria, Ciccone, Marco Matteo, and Forleo, Cinzia
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ARRHYTHMIA , *BRUGADA syndrome , *CARDIAC arrest , *VENTRICULAR tachycardia , *TELEMEDICINE , *IMPLANTABLE cardioverter-defibrillators , *ASYMPTOMATIC patients - Abstract
Telemedicine and remote monitoring devices, including implantable loop recorders (ILR), are increasingly adopted in the cardiologic setting. These are valuable tools in the arrhythmic stratification of patients at risk of sudden cardiac death, providing a tailored therapeutic management to prevent lethal arrhythmias. We report a case of an asymptomatic 18-year-old boy with a family history of syncope and cardiac arrest, who had a diagnosis of Brugada syndrome with an inducible type 1 pattern and carrier of a missense mutation of the SCN5A gene. In light of the risk factors, although not recommended by current guidelines, we decided to proceed with the implantation of an ILR with remote monitoring service. A few months later, an episode of asymptomatic sustained polymorphic ventricular tachycardia was promptly observed by the remote monitoring, leading to a timely implantation of a subcutaneous cardiac implantable defibrillator. [ABSTRACT FROM AUTHOR]
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- 2024
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16. Bifocal coronary sinus pacing and transcatheter tricuspid valve-in-valve implantation: an innovative combined approach.
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Santobuono, Vincenzo Ezio, Basile, Paolo, Gentile, Marco, Logiacco, Annalisa, Amati, Francesca, Carella, Maria Cristina, Memeo, Riccardo, Cillis, Emanuela De, Bortone, Alessandro Santo, Forleo, Cinzia, Ciccone, Marco Matteo, and Guaricci, Andrea Igoren
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One of the most common complications of tricuspid valve replacement is atrioventricular block (AVB), often requiring permanent pacing. The endocardial pacemaker lead, placed in the right ventricle, may sometimes interfere with the implanted prosthesis, causing its early dysfunction and the need for alternative sites of pacing. To the best of our knowledge, we present the first case of a successful combined percutaneous procedure consisting of the implantation of two leads in the coronary sinus for univentricular bifocal pacing and a transcatheter tricuspid valve-in-valve implantation in a young patient with severe dysfunction of the tricuspid bioprosthesis, requiring permanent pacing for a postsurgical complete atrioventricular block. Tricuspid valve replacement with surgery can often lead to cardiac rhythm disorders requiring a permanent pacemaker. This device may occasionally damage the tricuspid prosthesis. We present the first case of a combined procedure of tricuspid valve replacement and device implantation distant from the prosthesis without the need for a surgical approach in a young patient with severe tricuspid prosthesis malfunctioning and permanent pacing. Article highlights Right-sided infective endocarditis in young patients may be caused by intravenous drug use, leading to tricuspid valve injury and the need for valve replacement with a prosthesis. Complete atrioventricular block represents an important postoperative complication of valve surgery requiring, frequently, the implantation of a permanent pacemaker. The endocardial pacemaker lead in the right ventricle may sometimes interfere with the implanted bioprosthesis, causing its early degeneration with the need for prosthesis replacement and research of other sites of pacing. Surgical replacement of a malfunctioning tricuspid prosthesis is among the highest-risk procedures. A combined percutaneous implantation of two pacing leads in the coronary sinus for univentricular bifocal pacing and a transcatheter tricuspid valve-in-valve may be a safe and effective alternative to surgery in patients requiring a permanent pacing site. In the case of pacemaker dependency, the use of actively fixating leads should be preferable to passive ones in order to minimize the risk of lead dislocation. Other strategies such as pacing with epicardial leads, the use of his-bundle pacing, or leadless pacemakers were taken into account but not deemed suitable. The Heart Team plays a critical role in decision-making in these particular conditions. [ABSTRACT FROM AUTHOR]
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- 2024
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17. The Postoperative Paradoxical Septum (POPS): A Comprehensive Review on Physio-Pathological Mechanisms.
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Di Virgilio, Emanuele, Basile, Paolo, Carella, Maria Cristina, Monitillo, Francesco, Santoro, Daniela, Latorre, Michele Davide, D'Alessandro, Silvia, Fusini, Laura, Fazzari, Fabio, Pontone, Gianluca, and Guaricci, Andrea Igoren
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VENTRICULAR septum ,CARDIAC surgery ,CARDIAC imaging - Abstract
The interventricular septum (IVS) is a core myocardial structure involved in biventricular coupling and performance. Physiologically, during systole, it moves symmetrically toward the center of the left ventricle (LV) and opposite during diastole. Several pathological conditions produce a reversal or paradoxical septal motion, such as after uncomplicated cardiac surgery (CS). The postoperative paradoxical septum (POPS) was observed in a high rate of cases, representing a unicum in the panorama of paradoxical septa as it does not induce significant ventricular morpho-functional alterations nor negative clinical impact. Although it was previously considered a postoperative event, evidence suggests that it might also appear during surgery and gradually resolve over time. The mechanism behind this phenomenon is still debated. In this article, we will provide a comprehensive review of the various theories generated over the past fifty years to explain its pathological basis. Finally, we will attempt to give a heuristic interpretation of the biventricular postoperative motion pattern based on the switch of the ventricular anchor points. [ABSTRACT FROM AUTHOR]
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- 2024
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18. Correction to: Subjective Well-Being, Transnational Families and Social Integration of Married Immigrants in Italy
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Carella, Maria, García-Pereiro, Thaís, and Pace, Roberta
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- 2022
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19. Percutaneous extraction of a Micra AV transcatheter pacing system due to a rare sudden battery failure after 19 months from implantation: A first experience worldwide.
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Santobuono, Vincenzo Ezio, Basile, Paolo, Carella, Maria Cristina, Pomarico, Francesca, Favale, Stefano, Ciccone, Marco Matteo, and Guaricci, Andrea Igoren
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MEDICAL equipment reliability ,MEDICAL device removal ,FLUOROSCOPY ,ELECTROCARDIOGRAPHY ,ELECTRIC power supplies to apparatus ,CARDIAC pacemakers - Abstract
Introduction: Micra AV Transcatheter Pacing System (TPS) represents an innovative second‐generation leadless pacemaker which represents an effective alternative to conventional devices in selected cases. Intrinsic malfunctions of these devices are rare, requiring sometimes their retrieval. When performed in experienced centers, this procedure is safe. Case Presentation: We describe a case of sudden battery malfunction of a Micra AV TPS, which required the extraction and the placement of a new pacing system in the right ventricle. Discussion: This case, which has never been reported, highlights the need to a careful fluoroscopic evaluation and the usefulness of remote monitoring. [ABSTRACT FROM AUTHOR]
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- 2024
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20. CMR Mapping: The 4th-Era Revolution in Cardiac Imaging.
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Carrabba, Nazario, Amico, Mattia Alexis, Guaricci, Andrea Igoren, Carella, Maria Cristina, Maestrini, Viviana, Monosilio, Sara, Pedrotti, Patrizia, Ricci, Fabrizio, Monti, Lorenzo, Figliozzi, Stefano, Torlasco, Camilla, Barison, Andrea, Baggiano, Andrea, Scatteia, Alessandra, Pontone, Gianluca, and Dellegrottaglie, Santo
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HEART valve diseases ,CARDIAC magnetic resonance imaging ,CARDIAC imaging ,CORONARY disease ,MAGNETIC resonance imaging - Abstract
Cardiac magnetic resonance (CMR) imaging has witnessed substantial progress with the advent of parametric mapping techniques, most notably T1 and T2 mapping. These advanced techniques provide valuable insights into a wide range of cardiac conditions, including ischemic heart disease, cardiomyopathies, inflammatory cardiomyopathies, heart valve disease, and athlete's heart. Mapping could be the first sign of myocardial injury and oftentimes precedes symptoms, changes in ejection fraction, and irreversible myocardial remodeling. The ability of parametric mapping to offer a quantitative assessment of myocardial tissue properties addresses the limitations of conventional CMR methods, which often rely on qualitative or semiquantitative data. However, challenges persist, especially in terms of standardization and reference value establishment, hindering the wider clinical adoption of parametric mapping. Future developments should prioritize the standardization of techniques to enhance their clinical applicability, ultimately optimizing patient care pathways and outcomes. In this review, we endeavor to provide insights into the potential contributions of CMR mapping techniques in enhancing the diagnostic processes across a range of cardiac conditions. [ABSTRACT FROM AUTHOR]
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- 2024
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21. A comparison of intracardiac echocardiography and transesophageal echocardiography for guiding device closure of ostium secundum atrial septal defect: A 15‐year experience.
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De Cillis, Emanuela, Acquaviva, Tommaso, Ursi, Raffaella, Soldato, Nicolò, Basile, Paolo, Siena, Paola, Cristina Carella, Maria, Baggiano, Andrea, Mushtaq, Saima, Fusini, Laura, Rabbat, Mark G., Pontone, Gianluca, Bottio, Tomaso, Santo Bortone, Alessandro, Matteo Ciccone, Marco, Domenico Milano, Aldo, and Igoren Guaricci, Andrea
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ECHOCARDIOGRAPHY ,RADIOGRAPHIC magnification ,TRANSESOPHAGEAL echocardiography ,TIME ,ATRIAL fibrillation ,SURGICAL complications ,ATRIAL septal defects ,FLUOROSCOPY ,COMPARATIVE studies ,DESCRIPTIVE statistics ,HEART atrium ,TACHYCARDIA ,VASCULAR closure devices ,PATIENT safety - Abstract
Background and aim: Our aim was to evaluate the fluoroscopy time (FT), procedure time (PT) safety and efficacy when using intracardiac echocardiography (ICE) in comparison to transesophageal echocardiography (TEE) guidance for transcatheter closure of Ostium Secundum Atrial Septal Defect (OS‐ASD). Method: Ninety patients (n = 90) diagnosed with OS‐ASD underwent transcatheter closure between March 2006 and October 2021. Fifty‐seven patients were treated under ICE guidance, while 33 patients were treated under TEE guidance. Results: Mean age was 43 ± 15 years and 42 ± 10 years in the ICE and TEE groups, respectively. The majority of patients had a centrally placed defect. Median FT was 8.40 min versus 11.70 min (p <.001) in the ICE group compared to the TEE group, respectively. Median PT was 43 min versus 94 min (p <.001) in the ICE group compared to the TEE group, respectively. Both ICE and TEE provided high quality images. All interventions were completed successfully, except for one patient in the ICE group who experienced a device migration, the development of atrial tachycardia in one patient and atrial fibrillation in two patients in the ICE group which spontaneously cardioverted. There were no other complications. Conclusion: This study on a consistent cohort of patients with OS‐ASD undergoing percutaneous closure suggests that use of ICE is safe and efficacious. Compared to TEE, ICE demonstrated significantly shorter FT and PT, decreasing the entire duration of the procedure and x‐ray exposure. No relevant differences were observed in terms of success rate and complications. [ABSTRACT FROM AUTHOR]
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- 2024
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22. Left atrial strain is a good predictor of atrio‐ventricular synchrony in leadless pacemaker pacing.
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Troisi, Federica, Caccavo, Vincenzo P., Santobuono, Vincenzo E., Sgarra, Luca, Carella, Maria C., Basile, Paolo, Guaricci, Andrea I., and Grimaldi, Massimo
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ATRIOVENTRICULAR node ,ECHOCARDIOGRAPHY ,CARDIAC contraction ,ACCELEROMETERS ,CARDIAC pacing ,DESCRIPTIVE statistics ,CARDIAC pacemakers ,LEFT heart atrium - Abstract
Introduction: The importance of atrio‐ventricular synchrony pacing in sinus rhythm patients is known. To identify patients in whom leadless pacemakers are able to guarantee this atrio‐ventricular synchrony, we explored correlations among echocardiographic measures of left atrial (LA) size and function (doppler parameter and strain) with A4 amplitude in patients implanted with new generation Micra‐AV device. Methods: After implantation with Micra‐AV system, patients underwent device interrogation to evaluate AV synchrony based on the sensing of atrial mechanics and echocardiographic exam to assess LA morphology and LA function. Results: In the 21 studied patients (14 males, 72 ± 13 years), the A4 wave amplitude values inversely correlated with LA antero‐posterior diameter, LA volume, LA contraction strain and LA conduit strain, while they were positively related with LA reservoir strain. Discussion: Our results indicate a statistically significant relationship between morphological echocardiographic LA parameters and atrial contraction signal (A4), detected by leadless pacemakers and used to synchronize ventricular pacing with the atrium. Instantaneous LA function assessment obtained with LA strain provides incremental information over morphological parameters. LA strain evaluates atrial myocardial deformation during the whole cardiac cycle. We found higher value of A4 in patients that have grater absolute value of LAsr, LAscd and LAsct, that are simple and measurable parameters of LA functional capacity. Conclusion: Preimplant echocardiographic evaluation of the atrial contractility may be useful in predicting adequate A4 sensing and consequently a good atrio‐ventricular synchrony pacing. Echocardiography LA strain study seems promising in Micra‐AV patient selection. [ABSTRACT FROM AUTHOR]
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- 2024
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23. Improvement of myocardial contractility with leadless endocardial single-lead atrial sensing ventricular pacing in patients with prolonged PQ interval.
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Guaricci, Andrea Igoren, Santobuono, Vincenzo Ezio, Soldato, Nicolò, Basile, Paolo, Bozza, Nicola, Carella, Maria Cristina, Siena, Paola, Forleo, Cinzia, Pontone, Gianluca, and Ciccone, Marco Matteo
- Abstract
Aim: Micra AV represents a leadless endocardial pacing system able to detect atrial contractions providing atrioventricular synchrony. A reduction of myocardial contractility may be detected in case of first-degree atrioventricular block (AVB). Materials & methods: In six patients with first-degree AVB (PQ interval ≥220 msec) was evaluated the left ventricle global longitudinal strain (LV GLS) by speckle tracking (ST) echocardiography during single-lead atrial sensing ventricular pacing (VDD) stimulation as compared with spontaneous rhythm (SR), 24–48 h after Micra AV implantation. Results: A statistically significant difference between the two modalities was observed (LV GLS during SR: -14.7% [interquartile range (IQR) 5.5], LV GLS during VDD pacing: -16.1% [IQR 5.2]; p value = 0.041). Conclusion: Our preliminary results suggest an improvement of myocardial contractility with VDD pacing as compared with SR. The Micra AV is an electronic device placed in the heart chambers capable to supply the electrical activity of the heart. A reduction of cardiac contractility may be observed in patients with electrical disorders of the heart. In six patients affected by electrical cardiac disorders, we observed an improvement of cardiac contractility using Micra AV as compared with the spontaneous electrical activity of the heart. The results of this study suggest that in patients carrying this electronic device should be preferred a specific modality of activation of the device as compared with the spontaneous electrical activity of the heart in order to improve the contractility of the cardiac walls. An improvement of myocardial contractility was observed during VDD pacing as compared with spontaneous rhythm in 6 patients with first-degree AVB after 24–48 h from Micra AV implantation. [ABSTRACT FROM AUTHOR]
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- 2024
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24. The “dating game”: age differences at first sex of college students in Italy
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Carella, Maria, García-Pereiro, Thaís, Pace, Roberta, and Paterno, Anna
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- 2020
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25. Cardiac Magnetic Resonance as Risk Stratification Tool in Non-Ischemic Dilated Cardiomyopathy Referred for Implantable Cardioverter Defibrillator Therapy—State of Art and Perspectives.
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Argentiero, Adriana, Carella, Maria Cristina, Mandunzio, Donato, Greco, Giulia, Mushtaq, Saima, Baggiano, Andrea, Fazzari, Fabio, Fusini, Laura, Muscogiuri, Giuseppe, Basile, Paolo, Siena, Paola, Soldato, Nicolò, Napoli, Gianluigi, Santobuono, Vincenzo Ezio, Forleo, Cinzia, Garrido, Eduard Claver, Di Marco, Andrea, Pontone, Gianluca, and Guaricci, Andrea Igoren
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CARDIAC magnetic resonance imaging , *IMPLANTABLE cardioverter-defibrillators , *DILATED cardiomyopathy , *CARDIAC arrest , *VENTRICULAR arrhythmia - Abstract
Non-ischemic dilated cardiomyopathy (DCM) is a disease characterized by left ventricular dilation and systolic dysfunction. Patients with DCM are at higher risk for ventricular arrhythmias and sudden cardiac death (SCD). According to current international guidelines, left ventricular ejection fraction (LVEF) ≤ 35% represents the main indication for prophylactic implantable cardioverter defibrillator (ICD) implantation in patients with DCM. However, LVEF lacks sensitivity and specificity as a risk marker for SCD. It has been seen that the majority of patients with DCM do not actually benefit from the ICD implantation and, on the contrary, that many patients at risk of SCD are not identified as they have preserved or mildly depressed LVEF. Therefore, the use of LVEF as unique decision parameter does not maximize the benefit of ICD therapy. Multiple risk factors used in combination could likely predict SCD risk better than any single risk parameter. Several predictors have been proposed including genetic variants, electric indexes, and volumetric parameters of LV. Cardiac magnetic resonance (CMR) can improve risk stratification thanks to tissue characterization sequences such as LGE sequence, parametric mapping, and feature tracking. This review evaluates the role of CMR as a risk stratification tool in DCM patients referred for ICD. [ABSTRACT FROM AUTHOR]
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- 2023
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26. A Young Patient Presenting with Dilated Cardiomyopathy and Renal Infarction during Treatment with Isotretinoin: Mere Coincidence or Serious Side Effect of a Drug Commonly Used in Adolescence?
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Pepe, Martino, Napoli, Gianluigi, Carella, Maria Cristina, De Feo, Daniele, Tritto, Rocco, Guaricci, Andrea Igoren, Forleo, Cinzia, and Ciccone, Marco Matteo
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DILATED cardiomyopathy ,CARDIAC magnetic resonance imaging ,ISOTRETINOIN ,HEART failure ,INFARCTION ,IMPLANTABLE cardioverter-defibrillators - Abstract
Highlights: What are the main findings? We presented a case of new onset dilated cardiomyopathy (DCM) with renal infarction in a young man on a treatment with high-dose isotretinoin. Possible known causes of DCM using a complete cardiac imaging assessment, genetic testing, and laboratory analysis have been ruled out. What is the implication of the main finding? The possible association of DCM with isotretinoin assumption is, to the authors' opinion, deserving of further investigations. Isotretinoin or 13-cis-retinoic acid (RA) is one of the most effective and widely used drugs for the treatment of severe acne vulgaris. Despite being deemed safe, no definite consensus has been reached on the cardiovascular risk of RA derivatives. We report a case of heart failure due to dilated cardiomyopathy (DCM) and concomitant renal infarction occurring after 5 months of isotretinoin use in a previously healthy 18-year-old male. The patient, with a history of acne vulgaris, presented to our emergency department with left iliac fossa pain and effort dyspnea. A trans-thoracic echocardiogram showed DCM and severely reduced left ventricle ejection fraction (LVEF: 29%). During hospitalization, a total body computed tomography (CT) showed an ischemic lesion in the left kidney. Ischemic, autoimmune, infective, and heritable causes of DCM were ruled out. Cardiac magnetic resonance (CMR) evidenced LV circumferential mid-wall late gadolinium enhancement. Heart failure therapy was promptly started and up-titrated, but only poor LVEF improvement was detected overtime. Our case aims to raise awareness on rare life-threatening cardiovascular events possibly associated with isotretinoin use. To the best of our knowledge, this is the first described case of renal thromboembolism and severe DCM leading to implantable cardioverter-defibrillator (ICD) implantation occurring during isotretinoin treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
27. A novel multidisciplinary approach in an LMNA-mutated patient: the importance of considering the overall clinical picture for the early diagnosis
- Author
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Santobuono, Vincenzo Ezio, Guaricci, Andrea Igoren, Carulli, Eugenio, Bozza, Nicola, Pepe, Martino, Ranauro, Alfredo, Ranieri, Carlotta, Carella, Maria Cristina, Loizzi, Francesco, Resta, Nicoletta, Favale, Stefano, and Forleo, Cinzia
- Published
- 2022
- Full Text
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28. Population and Space in the Mediterranean: The Challenges of the 21st Century
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Carella, Maria, Bellis, Gil, and Parant, Alain
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POPULATION_SITUATION ,parasitic diseases ,fungi ,DEMOGRAPHY ,MEDITERRANEAN_COUNTRIES ,FERTILITY ,POPULATION_DISTRIBUTION ,AGE_DISTRIBUTION ,POPULATION_DYNAMICS ,humanities ,geographic locations ,POPULATION - Abstract
The Mediterranean region features diverse and overlapping socioeconomic and demographic dynamics, with collateral effects that have become increasingly more significant and difficult to solve. The region’s demographic evolution has been uneven. Indeed, while natural population increase in the countries of the northern shore has been weak for several decades (when it did not turn negative, as it did in Italy), the southern and eastern shores continue to benefit from a still considerable natural surplus despite a sharp decline in fertility (Angeli & Salvini, 2018; Bellis, Carella, Léger, Parant, 2021a). Furthermore, the contrasting demographic regimes along the northern (European), eastern (Asian) and southern (African) shores have resulted in a major change in the distribution of the populations whose composition by age group is also very different (Parant & Léger, 2020). In 2020, the countries of the African shore represent the most populated area of the Mediterranean Basin (39% vs. 38% for the countries of the European shore), while in 1950 the northern shore grouped two-thirds of the total population. Moreover, 47% of individuals on the southern shore and 42% of those residing on the eastern shore are now under 25 years old; while the under 25s represent just over a quarter of the population (26%) on the northern shore (Bellis, Carella, Léger, Parant, 2021b). The population of the northern shore is inexorably aging, whereas those of the southern and eastern shores have remained young despite the increase in life expectancy.
- Published
- 2022
29. Improvement of Left Ventricular Global Longitudinal Strain after 6-Month Therapy with GLP-1RAs Semaglutide and Dulaglutide in Type 2 Diabetes Mellitus: A Pilot Study.
- Author
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Basile, Paolo, Guaricci, Andrea Igoren, Piazzolla, Giuseppina, Volpe, Sara, Vozza, Alfredo, Benedetto, Marina, Carella, Maria Cristina, Santoro, Daniela, Monitillo, Francesco, Baggiano, Andrea, Mushtaq, Saima, Fusini, Laura, Fazzari, Fabio, Forleo, Cinzia, Ribecco, Nunziata, Pontone, Gianluca, Sabbà, Carlo, and Ciccone, Marco Matteo
- Subjects
GLOBAL longitudinal strain ,TYPE 2 diabetes ,SPECKLE tracking echocardiography ,ECHOCARDIOGRAPHY ,SEMAGLUTIDE - Abstract
(1) Background: Glucagone-Like Peptide-1 Receptor Agonists (GLP-1 RAs) (GLP-1 RAs) are incretine-based medications recommended in the treatment of type 2 Diabetes Mellitus (DM2) with atherosclerotic cardiovascular disease (ASCVD) or high or very high cardiovascular (CV) risk. However, knowledge of the direct mechanism of GLP-1 RAs on cardiac function is modest and not yet fully elucidated. Left ventricular (LV) Global Longitudinal Strain (GLS) with Speckle Tracking Echocardiography (STE) represents an innovative technique for the evaluation of myocardial contractility. (2) Methods: an observational, perspective, monocentric study was conducted in a cohort of 22 consecutive patients with DM2 and ASCVD or high/very high CV risk, enrolled between December 2019 and March 2020 and treated with GLP-1 RAs dulaglutide or semaglutide. The echocardiographic parameters of diastolic and systolic function were recorded at baseline and after six months of treatment. (3) Results: the mean age of the sample was 65 ± 10 years with a prevalence of the male sex (64%). A significant improvement in the LV GLS (mean difference: −1.4 ± 1.1%; p value < 0.001) was observed after six months of treatment with GLP-1 RAs dulaglutide or semaglutide. No relevant changes were seen in the other echocardiographic parameters. (4) Conclusions: six months of treatment with GLP-1 RAs dulaglutide or semaglutide leads to an improvement in the LV GLS in subjects with DM2 with and high/very high risk for ASCVD or with ASCVD. Further studies on larger populations and with a longer follow-up are warranted to confirm these preliminary results. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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30. The role of non-profit organisations in migration policies: Spain and Italy compared
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Carella, Maria, Gurrieri, Antonia Rosa, and Lorizio, Marilene
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Immigration policy -- Comparative analysis ,Nonprofit organizations -- Social aspects ,Government aid -- Analysis ,Government funding ,Business ,Social sciences - Abstract
The role of non-profit organizations in migration policies is analyzed by looking into immigrant services offered in Italy and Spain. The lack of awareness of population movement is seen as a reason behind the lack of government measures that look after the needs of immigrants, thus leading to non-profit organizations to take on the role with regard to immigrant concerns.
- Published
- 2007
31. Downgrading among higher education graduates in Italy and France: exploring regional differences.
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Carella, Maria and Léger, Jean-François
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- *
GRADUATE education , *HIGHER education , *REGIONAL differences , *SCIENTIFIC literature , *SOCIOECONOMIC factors - Abstract
In France and Italy – like all the countries of the European Union – the proportion of higher education graduates in the working population has continued to increase. At the same time, the number of jobs requiring this level of education has not grown as quickly. In France and Italy, this has meant a decrease in the proportion of tertiary graduates who occupy managerial positions, and a growing share of these graduates hold jobs as middle and low ranking employees. Several studies have investigated the phenomenon of professional downgrading, focusing on its structural determinants and socio-economic implications at the national level and examining international differences. Nevertheless, only a few studies explore disparities in over-education and compare nations at the regional level. By addressing the need for a spatial approach to this subject, which is so far lacking in the scientific literature, this paper examines the downgrading of higher education graduates in Italy and France at the regional level and discusses the real occupational returns for high levels of education. Using data from the Italian and French censuses, the findings of this analysis show significant sub-regional heterogeneities regarding access to managerial positions for graduates according to the territorial unit observed. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
32. Population and Space in the Mediterranean: The Challenges of the 21st Century (Introduction).
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Carella, Maria, Bellis, Gil, and Parant, Alain
- Subjects
- *
TWENTY-first century , *GLOBAL environmental change - Published
- 2022
33. Migration in the Mediterranean region: A response to crises and an emergency in its own right.
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Benassi, Federico, Carella, Maria, and Heins, Frank
- Subjects
- *
HUMAN migration patterns , *CRISES , *GEOPOLITICS - Abstract
Migration is an obvious response to political, economic, socio-demographic, and ecological crises. In recent decades, several crises have occurred in the Mediterranean region; consequently, migration has intensified, the geography of flows has been altered, and the roles of some countries within the Mediterranean migration system have rapidly changed. This paper aims to delineate an overview of migration flows in this region over the last 20 years, focusing on the new migration flows related to humanitarian crises. In doing so, the present study also examines similarities and differences between past and current migration factors that shape the decisions of individuals. Migration flows are closely linked to the needs and fears of European societies. Following this logic, and by analysing challenges related to demographic and geopolitical dimensions in the future scenario, this study discusses the necessity of new policy responses. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
34. Phosphorylation and Stabilization of PIN1 by JNK Promote Intrahepatic Cholangiocarcinoma Growth.
- Author
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Lepore, Alessio, Choy, Pui Man, Lee, Nathan C.W., Carella, Maria Annunziata, Favicchio, Rosy, Briones‐Orta, Marco A., Glaser, Shannon S., Alpini, Gianfranco, D'Santos, Clive, Tooze, Reuben M., Lorger, Mihaela, Syn, Wing‐Kin, Papakyriakou, Athanasios, Giamas, Georgios, Bubici, Concetta, and Papa, Salvatore
- Published
- 2021
- Full Text
- View/download PDF
35. Adverse Events in Italian Nursing Homes During the COVID-19 Epidemic: A National Survey.
- Author
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Lombardo, Flavia L., Salvi, Emanuela, Lacorte, Eleonora, Piscopo, Paola, Mayer, Flavia, Ancidoni, Antonio, Remoli, Giulia, Bellomo, Guido, Losito, Gilda, D'Ancona, Fortunato, Canevelli, Marco, Onder, Graziano, Vanacore, Nicola, Bacigalupo, Ilaria, Bertinato, Luigi, Carbonari, Patrizia, Carella, Maria Grazia, Confaloni, Annamaria, Crestini, Alessio, and Faralli, Carla
- Subjects
COVID-19 ,NURSING care facilities ,COVID-19 pandemic ,NURSING care facility administration ,MEDICAL care ,OLDER people - Abstract
Older people living in nursing homes (NHs) are particularly vulnerable in the ongoing COVID-19 pandemic, due to the high prevalence of chronic diseases and disabilities (e.g., dementia). The phenomenon of adverse events (AEs), intended as any harm or injury resulting from medical care or to the failure to provide care, has not yet been investigated in NHs during the pandemic. We performed a national survey on 3,292 NHs, either public or providing services both privately and within the national health system, out of the 3,417 NHs covering the whole Italian territory. An online questionnaire was addressed to the directors of each facility between March 24 and April 27, 2020. The list of NHs was provided by the Dementia Observatory, an online map of Italian services for people with dementia, which was one of the objectives of the implementation of the Italian National Dementia Plan. About 26% of residents in the Italian NHs for older people listed within the Dementia Observatory site had dementia. The objective of our study was to report the frequency of AEs that occurred during the months when SARS-CoV-2 spreading rate was at its highest in the Italian NHs and to identify which conditions and attributes were most associated with the occurrence of AEs by means of multivariate regression logistic analysis. Data are referred to 1,356 NHs that participated in the survey. The overall response rate was 41.2% over a time-period of six weeks (from March 24 to May 5). About one third of the facilities (444 out of 1,334) (33.3%) reported at least 1 adverse event, with a total of 2,000 events. Among the included NHs, having a bed capacity higher than the median of 60 beds (OR=1.57, CI95% 1.17–2.09; p=0.002), an observed increased in the use of psychiatric drugs (OR=1.80, CI95% 1.05–3.07; p=0.032), adopting physical restraint measures (OR=1.97, CI95% 1.47–2.64; p<0.001), residents hospitalized due to flu-like symptoms (OR =1.73, CI95% 1.28–2.32; p<0.001), and being located in specific geographic areas (OR=3.59, CI95% 1.81–7.08; OR = 2.90, CI95% 1.45–5.81 and OR = 4.02, CI05% 2.01–8.04 for, respectively, North-West, North-East and Centre vs South, p<0.001) were all factors positively associated to the occurrence of adverse events in the facility. Future recommendations for the management and care of residents in NHs during the COVID-19 pandemic should include specific statements for the most vulnerable populations, such as people with dementia. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
36. Balkan Countries in the World: Aging Process within the Age Structural Transition.
- Author
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Carella, Maria and Grubanov-Bošković, Sara
- Abstract
This article intends to approach the phenomenon of population aging within the conceptual framework of structural transition. In this work the authors put forward a method of defining the variety of evolutionary trajectories - the result of different sets of fertility-mortality interactions - on the global level and hence identify the position of each Balkan country within the worldwide demographic order of the past four decades (1971-2015). The authors then propose a specific index - the structural dissimilarity index - to measure the corresponding transformations inherent to the population age structure and link the results with the prospects that emerge on the basis of the interaction between fertility and mortality. This has finally enabled the authors to formulate some broad assumptions regarding the current and future intensity and trends of structural transformations. For this purpose, the authors have gathered a sample of 142 national populations, including all Balkan countries, with the exception of Montenegro, and employed different techniques such as Partial Order Structuple (Scalogram) Analysis with Coordinates (POSAC) and the cohort-component population projections for the timeframes 1971-2015 and 2015-2060. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
37. Age-Structural Transition and Demographic Windows Around the Mediterranean.
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Carella, Maria and Parant, Alain
- Published
- 2016
- Full Text
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38. Some Migration Dynamics Specific to Southern Europe: South-North and East-West Axis.
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Carella, Maria and Pace, Roberta
- Subjects
- *
EMIGRATION & immigration - Abstract
This article examines the magnitude and determinants of migration from east to west (Europe) following the collapse of communism, and from south (Africa) to north (Europe). Special attention is given to assessing numbers and characteristics (including illegal) of the flows, and also to reasons for and success of bilateral agreements and cooperative projects by the governments of Italy and Spain designed to check and control the flows. Notwithstanding tighter controls on visas for Third World nationals, migration to western Europe does not seem to have abated. In Italy, illegal migration from the east (Albania in particular) is connected, directly or indirectly, with the criminal underworld. The inventory of legal texts and agreement protocols between Spain and Morocco designed to resolve many issues relating to migration, reflect long-standing relations between the two countries. Political and economic relations between Italy and Albania, on the other hand, have developed only within the framework of recent policies. While the presence of Moroccans in Spain and Albanians in Italy is not yet demographically significant, the authors predict that, in the absence of further appropriate political and economic measures, numbers will increase. [ABSTRACT FROM AUTHOR]
- Published
- 2001
- Full Text
- View/download PDF
39. The Evolution of the First Cohabitation of Women in Spain: Change or Stability?
- Author
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García-Pereiro, Thaís, Pace, Roberta, and Carella, Maria
- Subjects
- *
UNMARRIED couples , *MARRIAGE , *SEPARATION (Law) , *HUMAN life cycle , *INTERPERSONAL relations , *CIVIL unions , *DOMESTIC partnership - Abstract
In Spain cohabitation the prevalence of cohabiting couples is no longer marginal. Not only the incidence but also the nature of cohabiting couples is diverse: in Spain cohabitation is considered a temporal alternative that generally ends with the legalization of the union (marriage). The main purpose of this paper is to examine the incidence, duration and development of cohabitation using a life course comparative approach, identifying also the profiles of women who split up against those who decide to marry. Results show the prevalence of the transition from cohabitation to marriage in Spain, establishing this type of union as a prelude and not as a definitive alternative to marriage. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
40. Unmasking the prevalence of amyloid cardiomyopathy in the real world: results from Phase 2 of the AC-TIVE study, an Italian nationwide survey.
- Author
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Merlo M, Pagura L, Porcari A, Cameli M, Vergaro G, Musumeci B, Biagini E, Canepa M, Crotti L, Imazio M, Forleo C, Cappelli F, Perfetto F, Favale S, Di Bella G, Dore F, Girardi F, Tomasoni D, Pavasini R, Rella V, Palmiero G, Caiazza M, Carella MC, Igoren Guaricci A, Branzi G, Caponetti AG, Saturi G, La Malfa G, Merlo AC, Andreis A, Bruno F, Longo F, Rossi M, Varrà GG, Saro R, Di Ienno L, De Carli G, Giacomin E, Arzilli C, Limongelli G, Autore C, Olivotto I, Badano L, Parati G, Perlini S, Metra M, Emdin M, Rapezzi C, and Sinagra G
- Subjects
- Humans, Middle Aged, Prevalence, Prospective Studies, Stroke Volume, Ventricular Function, Left, Amyloidosis diagnosis, Cardiomyopathies diagnostic imaging, Cardiomyopathies epidemiology, Heart Failure
- Abstract
Aim: To investigate the prevalence of amyloid cardiomyopathy (AC) and the diagnostic accuracy of echocardiographic red flags of AC among consecutive adult patients undergoing transthoracic echocardiogram for reason other than AC in 13 Italian institutions., Methods and Results: This is an Italian prospective multicentre study, involving a clinical and instrumental work-up to assess AC prevalence among patients ≥55 years old with an echocardiogram suggestive of AC (i.e. at least one echocardiographic red flag of AC in hypertrophic, non-dilated left ventricles with preserved ejection fraction). The study was registered at ClinicalTrials.gov (NCT04738266). Overall, 381 patients with an echocardiogram suggestive of AC were identified among a cohort of 5315 screened subjects, and 217 patients completed the investigations. A final diagnosis of AC was made in 62 patients with an estimated prevalence of 29% (95% confidence interval 23%-35%). Transthyretin-related AC (ATTR-AC) was diagnosed in 51 and light chain-related AC (AL-AC) in 11 patients. Either apical sparing or a combination of ≥2 other echocardiographic red flags, excluding interatrial septum thickness, provided a diagnostic accuracy >70%., Conclusion: In a cohort of consecutive adults with echocardiographic findings suggestive of AC and preserved left ventricular ejection fraction, the prevalence of AC (either ATTR or AL) was 29%. Easily available echocardiographic red flags, when combined together, demonstrated good diagnostic accuracy., (© 2022 European Society of Cardiology.)
- Published
- 2022
- Full Text
- View/download PDF
41. Importance of clinical suspicion and multidisciplinary management for early diagnosis of a cardiac laminopathy patient: A case report.
- Author
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Santobuono VE, Guaricci AI, Carulli E, Bozza N, Pepe M, Ranauro A, Ranieri C, Carella MC, Loizzi F, Resta N, Favale S, and Forleo C
- Abstract
Background: Laminopathies are rare diseases, whose cardiac manifestations are heterogeneous and, especially in their initial stage, similar to those of more common conditions, such as ischemic heart disease. Early diagnosis is essential, as these conditions can first manifest themselves with sudden cardiac death. Electrical complications usually appear before structural complications; therefore, it is important to take into consideration these rare genetic disorders for the differential diagnosis of brady and tachyarrhythmias, even when left ventricle systolic function is still preserved., Case Summary: A 60-year-old man, without history of previous disorders, presented in September 2019 to the emergency department because of the onset of syncope associated with hypotension. The patient was diagnosed with a high-grade atrioventricular block. A dual chamber pacemaker was implanted, but after the onset of a sustained ventricular tachycardia during physical exertion, a drug eluting stent was implanted on an intermediate stenosis on the left anterior descending artery, which had previously been considered non-haemodynamically significant. During the follow-up, the treating cardiologist, suspicious of the overall clinical picture, recommended a genetic test for the diagnosis of cardiomyopathies, which tested positive for a pathogenetic mutation of the lamin A/C gene. While awaiting the result of the genetic test and, later, the pacemaker to be upgraded to a biventricular defibrillator, a remote monitoring device was given to the patient in order to minimize in-person clinical evaluations during the coronavirus disease 2019-related lockdown., Conclusion: This case aims to raise awareness of the cardiological manifestations of laminopathies, which can be dangerously misdiagnosed as other, more common conditions., Competing Interests: Conflict-of-interest statement: No conflicts of interest to declare., (©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF
42. High Expression of Glycolytic Genes in Cirrhosis Correlates With the Risk of Developing Liver Cancer.
- Author
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Lee NCW, Carella MA, Papa S, and Bubici C
- Abstract
A marked increase in the rate of glycolysis is a key event in the pathogenesis of hepatocellular carcinoma (HCC), the main type of primary liver cancer. Liver cirrhosis is considered to be a key player in HCC pathogenesis as it precedes HCC in up to 90% of patients. Intriguingly, the biochemical events that underlie the progression of cirrhosis to HCC are not well understood. In this study, we examined the expression profile of metabolic gene transcripts in liver samples from patients with HCC and patients with cirrhosis. We found that gene expression of glycolytic enzymes is up-regulated in precancerous cirrhotic livers and significantly associated with an elevated risk for developing HCC. Surprisingly, expression levels of genes involved in mitochondrial oxidative metabolism are markedly increased in HCC compared to normal livers but remain unchanged in cirrhosis. Our findings suggest that key glycolytic enzymes such as hexokinase 2 (HK2), aldolase A (ALDOA), and pyruvate kinase M2 (PKM2) may represent potential markers and molecular targets for early detection and chemoprevention of HCC.
- Published
- 2018
- Full Text
- View/download PDF
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