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1. Outcomes of mechanical thrombectomy for medium vessel occlusion in acute ischemic stroke patients with ASPECTS 4–5 vs. 6–7: a retrospective, multicenter, and multinational study

Author

Musmar, Basel, Salim, Hamza Adel, Adeeb, Nimer, Yedavalli, Vivek, Lakhani, Dhairya, El Naamani, Kareem, Henninger, Nils, Sundararajan, Sri Hari, Kühn, Anna Luisa, Khalife, Jane, Ghozy, Sherief, Scarcia, Luca, Tan, Benjamin Y. Q., Regenhardt, Robert W., Heit, Jeremy J., Cancelliere, Nicole M., Bernstock, Joshua D., Rouchaud, Aymeric, Fiehler, Jens, Sheth, Sunil, Puri, Ajit S., Dyzmann, Christian, Colasurdo, Marco, Barreau, Xavier, Renieri, Leonardo, Filipe, João Pedro, Harker, Pablo, Radu, Răzvan Alexandru, Abdalkader, Mohamad, Klein, Piers, Marotta, Thomas R., Spears, Julian, Ota, Takahiro, Mowla, Ashkan, Jabbour, Pascal, Biswas, Arundhati, Clarençon, Frédéric, Siegler, James E., Nguyen, Thanh N., Varela, Ricardo, Baker, Amanda, Essibayi, Muhammed Amir, Altschul, David, Gonzalez, Nestor R., Möhlenbruch, Markus A., Costalat, Vincent, Gory, Benjamin, Stracke, Christian Paul, Aziz-Sultan, Mohammad Ali, Hecker, Constantin, Shaikh, Hamza, Liebeskind, David S., Pedicelli, Alessandro, Alexandre, Andrea M., Tancredi, Illario, Faizy, Tobias D., Kalsoum, Erwah, Lubicz, Boris, Patel, Aman B., Pereira, Vitor Mendes, Guenego, Adrien, and Dmytriw, Adam A.

Published
2025
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3. Comparative Efficacy of Flow Diverter Devices in the Treatment of Carotid Sidewall Intracranial Aneurysms: a Retrospective, Multicenter Study

Author

Dmytriw, Adam A., Salim, Hamza Adel, Musmar, Basel, Cancelliere, Nicole M., Griessenauer, Christoph J., Regenhardt, Robert W., Jones, Jesse, Tutino, Vincent, Hasan, Zuha, Limbucci, Nicola, Lay, Sovann V., Spears, Julian, Rabinov, James D., Harrigan, Mark R., Siddiqui, Adnan H., Levy, Elad I., Stapleton, Christopher J., Renieri, Leonardo, Cognard, Christophe, Shaikh, Hamza, Kühn, Anna Luisa, Möhlenbruch, Markus A., Tjoumakaris, Stavropoula I., Jabbour, Pascal, Taussky, Philipp, Settecase, Fabio, Heran, Manraj K. S., Nguyen, Anh, Volders, David, Harker, Pablo, Devia, Diego A., Puri, Ajit S., Psychogios, Marios, Puentes, Juan C., Leone, Giuseppe, Buono, Giuseppe, Tarantino, Margherita, Muto, Mario, Briganti, Francesco, Dalal, Shamsher, Gontu, Vamsi, Alcedo Guardia, Rodolfo E., Vicenty-Padilla, Juan C., Brouwer, Patrick, Schmidt, Matthias H., Schirmer, Clemens, Pickett, Gwynedd E., Andersson, Tommy, Söderman, Michael, Marotta, Thomas R., Cuellar-Saenz, Hugo, Thomas, Ajith J., Patel, Aman B., Mendes Pereira, Vitor, and Adeeb, Nimer

Published
2024
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4. Outcomes with General Anesthesia Compared to Conscious Sedation for Endovascular Treatment of Medium Vessel Occlusions: Results of an International Multicentric Study

Author

Radu, Răzvan Alexandru, Costalat, Vincent, Romoli, Michele, Musmar, Basel, Siegler, James E., Ghozy, Sherief, Khalife, Jane, Salim, Hamza, Shaikh, Hamza, Adeeb, Nimer, Cuellar-Saenz, Hugo H., Thomas, Ajith J., Kadirvel, Ramanathan, Abdalkader, Mohamad, Klein, Piers, Nguyen, Thanh N., Heit, Jeremy J., Regenhardt, Robert W., Bernstock, Joshua D., Patel, Aman B., Rabinov, James D., Stapleton, Christopher J., Cancelliere, Nicole M., Marotta, Thomas R., Mendes Pereira, Vitor, El Naamani, Kareem, Amllay, Abdelaziz, Tjoumakaris, Stavropoula I., Jabbour, Pascal, Meyer, Lukas, Fiehler, Jens, Faizy, Tobias D., Guerreiro, Helena, Dusart, Anne, Bellante, Flavio, Forestier, Géraud, Rouchaud, Aymeric, Mounayer, Charbel, Kühn, Anna Luisa, Puri, Ajit S., Dyzmann, Christian, Kan, Peter T., Colasurdo, Marco, Marnat, Gaultier, Berge, Jérôme, Barreau, Xavier, Sibon, Igor, Nedelcu, Simona, Henninger, Nils, Ota, Takahiro, Dofuku, Shogo, Yeo, Leonard L. L., Tan, Benjamin YQ, Gopinathan, Anil, Martinez-Gutierrez, Juan Carlos, Salazar-Marioni, Sergio, Sheth, Sunil, Renieri, Leonardo, Capirossi, Carolina, Mowla, Ashkan, Chervak, Lina M., Vagal, Achala, Khandelwal, Priyank, Biswas, Arundhati, Clarençon, Frédéric, Elhorany, Mahmoud, Premat, Kevin, Valente, Iacopo, Pedicelli, Alessandro, Alexandre, Andrea M., Filipe, João Pedro, Varela, Ricardo, Quintero-Consuegra, Miguel, Gonzalez, Nestor R., YMD, Markus A., Jesser, Jessica, Weyland, Charlotte, ter Schiphorst, Adrien, Yedavalli, Vivek, Harker, Pablo, Aziz, Yasmin, Gory, Benjamin, Paul Stracke, Christian, Hecker, Constantin, Killer-Oberpfalzer, Monika, Griessenauer, Christoph J., Hsieh, Cheng-Yang, Liebeskind, David S., Tancredi, Illario, Fahed, Robert, Lubicz, Boris, Essibayi, Muhammed Amir, Baker, Amanda, Altschul, David, Scarcia, Luca, Kalsoum, Erwah, Dmytriw, Adam A., and Guenego, Adrien

Published
2024
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5. Risk of adjacent level fracture after percutaneous vertebroplasty and kyphoplasty vs natural history for the management of osteoporotic vertebral compression fractures: a network meta-analysis of randomized controlled trials

Author

Essibayi, Muhammed Amir, Mortezaei, Ali, Azzam, Ahmed Y., Bangash, Ali Haider, Eraghi, Mohammad Mirahmadi, Fluss, Rose, Brook, Allan, Altschul, David J., Yassari, Reza, Chandra, Ronil V., Cancelliere, Nicole M., Pereira, Vitor Mendes, Jennings, Jack W., Gilligan, Christopher J., Bono, Christopher M., Hirsch, Joshua A., and Dmytriw, Adam A.

Published
2024
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6. Multicenter evaluation of mechanical thrombectomy for distal medium vessel occlusions with National Institute of Health Stroke Scale Scores ≥ 6 and ≤ 6

Author

Kühn, Anna Luisa, Puri, Ajit S., Salim, Hamza Adel, Musmar, Basel, Ghozy, Sherief, Siegler, James, Shaikh, Hamza, Khalife, Jane, Abdalkader, Mohamad, Klein, Piers, Nguyen, Thanh N., Heit, Jeremy J., Regenhardt, Robert W., Diestro, Jose Danilo Bengzon, Cancelliere, Nicole M., Sweid, Ahmad, Naamani, Kareem El, Hasan, Zuha, Gopinathan, Anil, Amllay, Abdelaziz, Meyer, Lukas, Dusart, Anne, Bellante, Flavio, Forestier, Géraud, Rouchaud, Aymeric, Saleme, Suzana, Mounayer, Charbel, Fiehler, Jens, Dyzmann, Christian, Kan, Peter T., Singh, Jasmeet, Colasurdo, Marco, Marnat, Gaultier, Berge, Jérôme, Barreau, Xavier, Sibon, Igor, Nedelcu, Simona, Henninger, Nils, Marotta, Thomas R., Stapleton, Christopher J., Rabinov, James D., Ota, Takahiro, Dofuku, Shogo, Yeo, Leonard LL., Tan, Benjamin Y. Q., Martinez-Gutierrez, Juan Carlos, Salazar-Marioni, Sergio, Sheth, Sunil, Renieri, Leonardo, Capirossi, Carolina, Mowla, Ashkan, Tjoumakaris, Stavropoula I., Jabbour, Pascal, Khandelwal, Priyank, Biswas, Arundhati, Clarençon, Frédéric, Elhorany, Mahmoud, Premat, Kevin, Valente, Iacopo, Pedicelli, Alessandro, Filipe, João Pedro, Varela, Ricardo, Quintero-Consuegra, Miguel, Gonzalez, Nestor R., Möhlenbruch, Markus A., Jesser, Jessica, Costalat, Vincent, ter Schiphorst, Adrien, Yedavalli, Vivek, Harker, Pablo, Chervak, Lina, Aziz, Yasmin, Gory, Benjamin, Stracke, Christian Paul, Hecker, Constantin, Killer-Oberpfalzer, Monika, Griessenauer, Christoph J., Thomas, Ajith, Hsieh, Cheng-Yang, Liebeskind, David S., Radu, Răzvan Alexandru, Alexandre, Andrea M., Fahed, Robert, Tancredi, Illario, Faizy, Tobias D., Weyland, Charlotte, Lubicz, Boris, Patel, Aman B., Pereira, Vitor Mendes, Guenego, Adrien, and Dmytriw, Adam A.

Published
2024
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10. Dual Layer vs Single Layer Woven EndoBridge Device in the Treatment of Intracranial Aneurysms: A Propensity Score-Matched Analysis

Author

Dmytriw, Adam A., Salim, Hamza, Musmar, Basel, Aslan, Assala, Cancelliere, Nicole M., McLellan, Rachel M., Algin, Oktay, Ghozy, Sherief, Dibas, Mahmoud, Lay, Sovann V., Guenego, Adrien, Renieri, Leonardo, Carnevale, Joseph, Saliou, Guillaume, Mastorakos, Panagiotis, Naamani, Kareem El, Shotar, Eimad, Premat, Kevin, Möhlenbruch, Markus, Kral, Michael, Doron, Omer, Chung, Charlotte, Salem, Mohamed M., Lylyk, Ivan, Foreman, Paul M., Vachhani, Jay A., Shaikh, Hamza, Župančić, Vedran, Hafeez, Muhammad U., Catapano, Joshua, Waqas, Muhammad, Tutino, Vincent M., Ibrahim, Mohamed K., Mohammed, Marwa A., Imamoglu, Cetin, Bayrak, Ahmet, Rabinov, James D., Ren, Yifan, Schirmer, Clemens M., Piano, Mariangela, Kühn, Anna L., Michelozzi, Caterina, Elens, Stéphanie, Starke, Robert M., Hassan, Ameer E., Ogilvie, Mark, Sporns, Peter, Jones, Jesse, Brinjikji, Waleed, Nawka, Marie T., Psychogios, Marios, Ulfert, Christian, Diestro, Jose Danilo Bengzon, Pukenas, Bryan, Burkhardt, Jan-Karl, Huynh, Thien, Martinez-Gutierrez, Juan Carlos, Essibayi, Muhammed Amir, Sheth, Sunil A., Spiegel, Gary, Tawk, Rabih, Lubicz, Boris, Panni, Pietro, Puri, Ajit S., Pero, Guglielmo, Nossek, Erez, Raz, Eytan, Killer-Oberfalzer, Monika, Griessenauer, Christoph J., Asadi, Hamed, Siddiqui, Adnan, Brook, Allan L., Altschul, David, Ducruet, Andrew F., Albuquerque, Felipe C., Regenhardt, Robert W., Stapleton, Christopher J., Kan, Peter, Kalousek, Vladimir, Lylyk, Pedro, Boddu, Srikanth, Knopman, Jared, Aziz-Sultan, Mohammad A., Tjoumakaris, Stavropoula I., Clarençon, Frédéric, Limbucci, Nicola, Cuellar-Saenz, Hugo H., Jabbour, Pascal M., Pereira, Vitor Mendes, Patel, Aman B., and Adeeb, Nimer

Published
2024
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11. Infusing 21st-Century Competencies into Scripted Foundation Phase Literacy Lessons

Author

Cancelliere, Semoni, Ramsaroop, Sarita, and Petersen, Nadine

Abstract

Background: Despite large-scale interventions aimed at developing literacy skills, children's reading competence levels in South Africa continue to remain an area of concern. In addition, the need to prepare learners for the increased demands of a fast-changing world of learning and working is gaining attention in educational policy and practice. Aim: Using a qualitative multi-site case study research design, the authors aimed to explore teachers' understanding and enactment of scripted literacy lessons that are designed to promote 21st-century competencies. Setting: Five Grade 1 teachers were selected from four schools, three of which are in periurban and the other in a township area. Methods: Data were generated in two phases across three teaching cycles. In the first phase, lessons were observed and recorded on video. The second phase consisted of stimulated recall interviews (SRIs) in which teachers commented on their recorded lessons. Results: The findings showed that when teachers had relevant prior knowledge of specific competencies, they were better positioned to leverage these as a basis for their lessons. However, the findings also indicated that teachers' entrenched methods and ways of thinking were obstacles for change. Conclusion: Training and development opportunities should pay sufficient attention to the practicalities of changing pedagogies and using scripted lesson plans. Contribution: The findings contribute to knowledge on the affordances and challenges when designing training opportunities aimed at integrating 21st-century competencies into scripted literacy lessons.

Published
2023

13. Long-Term Follow-Up of Cerebral Aneurysms Completely Occluded at 6 Months After Intervention with the Woven EndoBridge (WEB) Device: a Retrospective Multicenter Observational Study

Author

El Naamani, Kareem, Mastorakos, Panagiotis, Adeeb, Nimer, Lan, Mathews, Castiglione, James, Khanna, Omaditya, Diestro, Jose Danilo Bengzon, McLellan, Rachel M., Dibas, Mahmoud, Vranic, Justin E., Aslan, Assala, Cuellar-Saenz, Hugo H., Guenego, Adrien, Carnevale, Joseph, Saliou, Guillaume, Ulfert, Christian, Möhlenbruch, Markus, Foreman, Paul M., Vachhani, Jay A., Hafeez, Muhammad U., Waqas, Muhammad, Tutino, Vincent M., Rabinov, James D., Ren, Yifan, Michelozzi, Caterina, Spears, Julian, Panni, Pietro, Griessenauer, Christoph J., Asadi, Hamed, Regenhardt, Robert W., Stapleton, Christopher J., Ghozy, Sherief, Siddiqui, Adnan, Patel, Nirav J., Kan, Peter, Boddu, Srikanth, Knopman, Jared, Aziz-Sultan, Mohammad A., Zanaty, Mario, Ghosh, Ritam, Abbas, Rawad, Amllay, Abdelaziz, Tjoumakaris, Stavropoula I., Gooch, Michael R., Cancelliere, Nicole M., Herial, Nabeel A., Rosenwasser, Robert H., Zarzour, Hekmat, Schmidt, Richard F., Pereira, Vitor Mendes, Patel, Aman B., Jabbour, Pascal, and Dmytriw, Adam A.

Published
2024
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14. Mechanical Thrombectomy Versus Intravenous Thrombolysis in Distal Medium Vessel Acute Ischemic Stroke: A Multinational Multicenter Propensity Score-Matched Study

Author

Hamza Adel Salim, Vivek Yedavalli, Basel Musmar, Nimer Adeeb, Muhammed Amir Essibayi, Kareem El Naamani, Nils Henninger, Sri Hari Sundararajan, Anna Luisa Kühn, Jane Khalife, Sherief Ghozy, Luca Scarcia, Benjamin Y.Q. Tan, Benjamin Pulli, Jeremy J. Heit, Robert W. Regenhardt, Nicole M. Cancelliere, Joshua D. Bernstock, Aymeric Rouchaud, Jens Fiehler, Sunil Sheth, Ajit S. Puri, Christian Dyzmann, Marco Colasurdo, Xavier Barreau, Leonardo Renieri, João Pedro Filipe, Pablo Harker, Razvan Alexandru Radu, Thomas R. Marotta, Julian Spears, Takahiro Ota, Ashkan Mowla, Pascal Jabbour, Arundhati Biswas, Frédéric Clarençon, James E. Siegler, Thanh N. Nguyen, Ricardo Varela, Amanda Baker, David Altschul, Nestor R. Gonzalez, Markus A. Möhlenbruch, Vincent Costalat, Benjamin Gory, Christian Paul Stracke, Mohammad Ali Aziz-Sultan, Constantin Hecker, Hamza Shaikh, David S. Liebeskind, Alessandro Pedicelli, Andrea M. Alexandre, Illario Tancredi, Tobias D. Faizy, Erwah Kalsoum, Boris Lubicz, Aman B. Patel, Vitor Mendes Pereira, Adrien Guenego, and Adam A. Dmytriw

Subjects
stroke, mechanical thrombectomy, distal medium vessel occlusions, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background and Purpose The management of acute ischemic stroke (AIS) due to distal medium vessel occlusion (DMVO) remains uncertain, particularly in comparing the effectiveness of intravenous thrombolysis (IVT) plus mechanical thrombectomy (MT) versus IVT alone. This study aimed to evaluate the safety and efficacy in DMVO patients treated with either MT-IVT or IVT alone. Methods This multinational study analyzed data from 37 centers across North America, Asia, and Europe. Patients with AIS due to DMVO were included, with data collected from September 2017 to July 2023. The primary outcome was functional independence, with secondary outcomes including mortality and safety measures such as types of intracerebral hemorrhage. Results The study involved 1,057 patients before matching, and 640 patients post-matching. Functional outcomes at 90 days showed no significant difference between groups in achieving good functional recovery (modified Rankin Scale 0–1 and 0–2), with adjusted odds ratios (OR) of 1.21 (95% confidence interval [CI] 0.81 to 1.79; P=0.35) and 1.00 (95% CI 0.66 to 1.51; P>0.99), respectively. Mortality rates at 90 days were similar between the two groups (OR 0.75, 95% CI 0.44 to 1.29; P=0.30). The incidence of symptomatic intracerebral hemorrhage was comparable, but any type of intracranial hemorrhage was significantly higher in the MT-IVT group (OR 0.43, 95% CI 0.29 to 0.63; P

Published
2024
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15. Use of the pRESET LITE thrombectomy device in combined approach for medium vessel occlusions: A multicenter evaluation

Author

Wang, Maud, Henkes, Hans, Ghozy, Sherief, Siegler, James E., Shaikh, Hamza, Khalife, Jane, Abdalkader, Mohamad, Klein, Piers, Nguyen, Thanh N., Heit, Jeremy J., Sweid, Ahmad, Naamani, Kareem El, Regenhardt, Robert W., Diestro, Jose Danilo Bengzon, Cancelliere, Nicole M., Amllay, Abdelaziz, Meyer, Lukas, Dusart, Anne, Bellante, Flavio, Forestier, Géraud, Rouchaud, Aymeric, Saleme, Suzana, Mounayer, Charbel, Fiehler, Jens, Kühn, Anna Luisa, Puri, Ajit S., Dyzmann, Christian, Kan, Peter T., Colasurdo, Marco, Marnat, Gaultier, Berge, Jérôme, Barreau, Xavier, Sibon, Igor, Nedelcu, Simona, Henninger, Nils, Weyland, Charlotte, Marotta, Thomas R., Stapleton, Christopher J., Rabinov, James D., Ota, Takahiro, Dofuku, Shogo, Yeo, Leonard LL., Tan, Benjamin Y. Q., Martinez-Gutierrez, Juan Carlos, Salazar-Marioni, Sergio, Sheth, Sunil, Renieri, Leonardo, Capirossi, Carolina, Mowla, Ashkan, Tjoumakaris, Stavropoula I., Jabbour, Pascal, Khandelwal, Priyank, Biswas, Arundhati, Clarençon, Frédéric, Elhorany, Mahmoud, Premat, Kevin, Valente, Iacopo, Pedicelli, Alessandro, Filipe, João Pedro, Varela, Ricardo, Quintero-Consuegra, Miguel, Gonzalez, Nestor R., Möhlenbruch, Markus A., Jesser, Jessica, Costalat, Vincent, ter Schiphorst, Adrien, Yedavalli, Vivek, Harker, Pablo, Chervak, Lina M., Aziz, Yasmin, Gory, Benjamin, Stracke, Christian Paul, Hecker, Constantin, Killer-Oberpfalzer, Monika, Griessenauer, Christoph J., Thomas, Ajith J., Hsieh, Cheng-Yang, Liebeskind, David S., Radu, Răzvan Alexandru, Alexandre, Andrea M., Tancredi, Illario, Faizy, Tobias D., Patel, Aman B., Pereira, Vitor Mendes, Fahed, Robert, Lubicz, Boris, Dmytriw, Adam A., and Guenego, Adrien

Published
2024
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16. Transcriptome‐wide gene expression outlier analysis pinpoints therapeutic vulnerabilities in colorectal cancer

Author

Elisa Mariella, Gaia Grasso, Martina Miotto, Kristi Buzo, Nicole Megan Reilly, Pietro Andrei, Pietro Paolo Vitiello, Giovanni Crisafulli, Sabrina Arena, Giuseppe Rospo, Giorgio Corti, Annalisa Lorenzato, Carlotta Cancelliere, Ludovic Barault, Giulia Gionfriddo, Michael Linnebacher, Mariangela Russo, Federica Di Nicolantonio, and Alberto Bardelli

Subjects
biomarkers, colorectal cancer, drug targets, gene expression outliers, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Multiple strategies are continuously being explored to expand the drug target repertoire in solid tumors. We devised a novel computational workflow for transcriptome‐wide gene expression outlier analysis that allows the systematic identification of both overexpression and underexpression events in cancer cells. Here, it was applied to expression values obtained through RNA sequencing in 226 colorectal cancer (CRC) cell lines that were also characterized by whole‐exome sequencing and microarray‐based DNA methylation profiling. We found cell models displaying an abnormally high or low expression level for 3533 and 965 genes, respectively. Gene expression abnormalities that have been previously associated with clinically relevant features of CRC cell lines were confirmed. Moreover, by integrating multi‐omics data, we identified both genetic and epigenetic alternations underlying outlier expression values. Importantly, our atlas of CRC gene expression outliers can guide the discovery of novel drug targets and biomarkers. As a proof of concept, we found that CRC cell lines lacking expression of the MTAP gene are sensitive to treatment with a PRMT5‐MTA inhibitor (MRTX1719). Finally, other tumor types may also benefit from this approach.

Published
2024
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18. Predictors and Outcomes of Excellent Recanalization Versus Successful Recanalization After Thrombectomy in Proximal and Distal Medium Vessel Occlusion Strokes: A Multinational Study

Author

Vivek Yedavalli, Hamza Adel Salim, Basel Musmar, Nimer Adeeb, Kareem El Naamani, Nils Henninger, Sri Hari Sundararajan, Anna Luisa Kühn, Jane Khalife, Sherief Ghozy, Luca Scarcia, Benjamin Y. Q. Tan, Jeremy J. Heit, Robert W. Regenhardt, Nicole M. Cancelliere, Joshua D. Bernstock, Aymeric Rouchaud, Jens Fiehler, Sunil Sheth, Muhammed Amir Essibayi, Ajit S. Puri, Christian Dyzmann, Marco Colasurdo, Xavier Barreau, Leonardo Renieri, João Pedro Filipe, Pablo Harker, Răzvan Alexandru Radu, Mohamad Abdalkader, Piers Klein, Thomas R. Marotta, Julian Spears, Takahiro Ota, Ashkan Mowla, Pascal Jabbour, Arundhati Biswas, Frédéric Clarençon, James E. Siegler, Thanh N. Nguyen, Ricardo Varela, Amanda Baker, David Altschul, Nestor R. Gonzalez, Markus A. Möhlenbruch, Vincent Costalat, Benjamin Gory, Christian Paul Stracke, Mohammad Ali Aziz‐Sultan, Constantin Hecker, Hamza Shaikh, David S. Liebeskind, Alessandro Pedicelli, Andrea M. Alexandre, Illario Tancredi, Tobias D. Faizy, Erwah Kalsoum, Boris Lubicz, Aman B. Patel, Vitor Mendes Pereira, Adrien Guenego, and Adam A. Dmytriw

Subjects
acute ischemic stroke, mechanical thrombectomy, medium vessel occlusions, mTICI score, Neurology. Diseases of the nervous system, RC346-429, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background Acute ischemic stroke arising from medium vessel occlusions (MeVO) poses substantial challenges in treatment and management. This study aims to elucidate the outcomes and factors contributing to achieving excellent recanalization (modified Thrombolysis in Cerebral Infarction [mTICI] 2c–3) versus successful recanalization (mTICI 2b) in patients with MeVO stroke undergoing mechanical thrombectomy (MT). Methods We conducted a multinational study analyzing data from the MAD‐MT (Multicenter Analysis of Distal Medium Vessel Occlusions: Effect of Mechanical Thrombectomy) registry, encompassing 37 centers across North America, Asia, and Europe, collected between September 2017 and July 2023. The study included acute ischemic stroke patients with MeVO treated with MT, with or without intravenous thrombolysis, who achieved mTICI 2b–3 post‐MT. Results Among 1463 patients with successful recanalization (mTICI 2b–3), 523 achieved mTICI 2b recanalization, and 940 achieved mTICI 2c–3. Distal occlusions exhibited higher odds of excellent recanalization compared with proximal MeVO vessel occlusions (odds ratio, 1.58; 95% CI, 1.17–2.15; P = 0.003). Cardioembolic stroke pathogenesis was associated with a higher likelihood of excellent recanalization (1.67; 95% CI, 1.07–2.59; P = 0.018). Patients achieving mTICI 2c–3 recanalization demonstrated lower initial National Institutes of Health Stroke Scale scores, significant improvements in postprocedural National Institutes of Health Stroke Scale shift, and a higher percentage of favorable 90‐day outcomes compared with those with mTICI 2b. However, no significant difference in 90‐day mortality rates was observed. Conclusion This study underscores that among patients with MeVO stroke with successful recanalization (mTICI 2b–3) there is higher likelihood of achieving excellent recanalization (mTICI 2c–3) in distal occlusions and cardioembolic pathogenesis. mTICI 2c–3 scores post‐MT correlate with improved clinical outcomes compared with mTICI 2b, affirming the superiority of excellent recanalization over successful recanalization in patients with MeVO stroke. Further prospective studies and randomized controlled trials are warranted for validation.

Published
2024
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21. Improving Rehabilitation Research to Optimize Care and Outcomes for People with Chronic Primary Low Back Pain: Methodological and Reporting Recommendations from a WHO Systematic Review Series

Author

Cancelliere, Carol, Yu, Hainan, Southerst, Danielle, Connell, Gaelan, Verville, Leslie, Bussières, André, Gross, Douglas P., Pereira, Paulo, Mior, Silvano, Tricco, Andrea C., Cedraschi, Christine, Brunton, Ginny, Nordin, Margareta, Shearer, Heather M., Wong, Jessica J., Hayden, Jill A., Ogilvie, Rachel, Wang, Dan, Côté, Pierre, and Hincapié, Cesar A.

Published
2023
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22. Systematic Review Procedures for the World Health Organization (WHO) Evidence Syntheses on Benefits and Harms of Structured and Standardized Education/Advice, Structured Exercise Programs, Transcutaneous Electrical Nerve Stimulation (TENS), and Needling Therapies for the Management of Chronic Low Back Pain in Adults

Author

Cancelliere, Carol, Verville, Leslie, Southerst, Danielle, Yu, Hainan, Hayden, Jill A., Ogilvie, Rachel, Bussières, André, Gross, Douglas P., Pereira, Paulo, Mior, Silvano, Tricco, Andrea C., Cedraschi, Christine, Brunton, Ginny, Nordin, Margareta, Wong, Jessica J., Shearer, Heather M., Connell, Gaelan, and Hincapié, Cesar A.

Published
2023
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23. Systematic Review to Inform a World Health Organization (WHO) Clinical Practice Guideline: Benefits and Harms of Needling Therapies for Chronic Primary Low Back Pain in Adults

Author

Yu, Hainan, Wang, Dan, Verville, Leslie, Southerst, Danielle, Bussières, André, Gross, Douglas P., Pereira, Paulo, Mior, Silvano, Tricco, Andrea C., Cedraschi, Christine, Brunton, Ginny, Nordin, Margareta, Shearer, Heather M., Wong, Jessica J., Connell, Gaelan, Myrtos, Danny, da Silva-Oolup, Sophia, Young, James J., Funabashi, Martha, Romanelli, Andrew, Lee, Joyce G. B., Stuber, Kent, Guist, Brett, Muñoz Laguna, Javier, Hofstetter, Léonie, Murnaghan, Kent, Hincapié, Cesar A., and Cancelliere, Carol

Published
2023
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24. Systematic Review to Inform a World Health Organization (WHO) Clinical Practice Guideline: Benefits and Harms of Structured and Standardized Education or Advice for Chronic Primary low back pain in Adults

Author

Southerst, Danielle, Hincapié, Cesar A., Yu, Hainan, Verville, Leslie, Bussières, André, Gross, Douglas P., Pereira, Paulo, Mior, Silvano, Tricco, Andrea C., Cedraschi, Christine, Brunton, Ginny, Nordin, Margareta, Wong, Jessica J., Connell, Gaelan, Shearer, Heather M., DeSouza, Astrid, Muñoz Laguna, Javier, Lee, Joyce G. B., To, Daphne, Lalji, Rahim, Stuber, Kent, Funabashi, Martha, Hofstetter, Léonie, Myrtos, Danny, Romanelli, Andrew, Guist, Brett, Young, James J., da Silva-Oolup, Sophia, Stupar, Maja, Wang, Dan, Murnaghan, Kent, and Cancelliere, Carol

Published
2023
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25. Systematic Review to Inform a World Health Organization (WHO) Clinical Practice Guideline: Benefits and Harms of Transcutaneous Electrical Nerve Stimulation (TENS) for Chronic Primary Low Back Pain in Adults

Author

Verville, Leslie, Hincapié, Cesar A., Southerst, Danielle, Yu, Hainan, Bussières, André, Gross, Douglas P., Pereira, Paulo, Mior, Silvano, Tricco, Andrea C., Cedraschi, Christine, Brunton, Ginny, Nordin, Margareta, Connell, Gaelan, Shearer, Heather M., Wong, Jessica J., Hofstetter, Léonie, Romanelli, Andrew, Guist, Brett, To, Daphne, Stuber, Kent, da Silva-Oolup, Sophia, Stupar, Maja, Myrtos, Danny, Lee, Joyce G.B., DeSouza, Astrid, Muñoz Laguna, Javier, Murnaghan, Kent, and Cancelliere, Carol

Published
2023
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26. Systematic Review to Inform a World Health Organization (WHO) Clinical Practice Guideline: Benefits and Harms of Structured Exercise Programs for Chronic Primary Low Back Pain in Adults

Author

Verville, Leslie, Ogilvie, Rachel, Hincapié, Cesar A., Southerst, Danielle, Yu, Hainan, Bussières, André, Gross, Douglas P., Pereira, Paulo, Mior, Silvano, Tricco, Andrea C., Cedraschi, Christine, Brunton, Ginny, Nordin, Margareta, Connell, Gaelan, Wong, Jessica J., Shearer, Heather M., Lee, Joyce G. B., Wang, Dan, Hayden, Jill A., and Cancelliere, Carol

Published
2023
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28. Off-Label use of Woven EndoBridge device for intracranial brain aneurysm treatment: Modeling of occlusion outcome

Author

Dibas, Mahmoud, Spears, Julian, Sundararajan, Sri Hari, Al Balush, Ali, Vranic, Justin E., Inoue, Yasuaki, Mirshahi, Shervin, Alotaibi, Naif M., Harker, Pablo, Tutino, Vincent M., Sporns, Peter, Brehm, Alex, Essibayi, Muhammed Amir, Jabal, Mohamed Sobhi, Musmar, Basel, Adeeb, Nimer, Salim, Hamza, Aslan, Assala, Cancelliere, Nicole M., McLellan, Rachel M., Algin, Oktay, Ghozy, Sherief, Lay, Sovann V., Guenego, Adrien, Renieri, Leonardo, Carnevale, Joseph, Saliou, Guillaume, Mastorakos, Panagiotis, Naamani, Kareem El, Shotar, Eimad, Premat, Kevin, Möhlenbruch, Markus, Kral, Michael, Doron, Omer, Chung, Charlotte, Salem, Mohamed M, Lylyk, Ivan, Foreman, Paul M., Vachhani, Jay A., Shaikh, Hamza, Župančić, Vedran, Hafeez, Muhammad U., Catapano, Joshua, Waqas, Muhammad, Yavuz, Kivilcim, Gunes, Yasin Celal, Rabinov, James D., Ren, Yifan, Schirmer, Clemens M., Piano, Mariangela, Kühn, Anna L., Michelozzi, Caterina, Starke, Robert M., Hassan, Ameer, Ogilvie, Mark, Nguyen, Anh, Jones, Jesse, Brinjikji, Waleed, Nawka, Marie T., Psychogios, Marios, Ulfert, Christian, Diestro, Jose Danilo Bengzon, Pukenas, Bryan, Burkhardt, Jan-Karl, Huynh, Thien, Gutierrez, Juan Carlos Martinez, Sheth, Sunil A., Spiegel, Gary, Tawk, Rabih, Lubicz, Boris, Panni, Pietro, Puri, Ajit S., Pero, Guglielmo, Nossek, Erez, Raz, Eytan, Killer-Oberfalzer, Monika, Griessenauer, Christoph J., Asadi, Hamed, Siddiqui, Adnan, Brook, Allan L., Haranhalli, Neil, Ducruet, Andrew F., Albuquerque, Felipe C., Regenhardt, Robert W., Stapleton, Christopher J., Kan, Peter, Kalousek, Vladimir, Lylyk, Pedro, Boddu, Srikanth, Knopman, Jared, Aziz-Sultan, Mohammad A., Tjoumakaris, Stavropoula I., Clarençon, Frédéric, Limbucci, Nicola, Cuellar-Saenz, Hugo H., Jabbour, Pascal M, Pereira, Vitor Mendes, Patel, Aman B., Altschul, David, and Dmytriw, Adam A.

Published
2024
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30. Decoupling immunomodulatory properties from lipid binding in the α-pore-forming toxin Sticholysin II

Author

Rivero-Hernández, Ada L., Hervis, Yadira P., Valdés-Tresanco, Mario E., Escalona-Rodríguez, Felipe A., Cancelliere, Rocco, Relova-Hernández, Ernesto, Romero-Hernández, Glenda, Pérez-Rivera, Eric, Torres-Palacios, Yusniel, Cartaya-Quintero, Patricia, Ros, Uris, Porchetta, Alessandro, Micheli, Laura, Fernández, Luis E., Laborde, Rady, Álvarez, Carlos, Sagan, Sandrine, Lanio, Maria Eliana, and Pazos Santos, Isabel F.

Published
2024
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31. Differential effect of asparagine and glutamine removal on three adenocarcinoma cell lines

Author

Greta Pessino, Leonardo Lonati, Claudia Scotti, Silvia Calandra, Ornella Cazzalini, Ombretta Iaria, Andrea Previtali, Giorgio Baiocco, Paola Perucca, Anna Tricarico, Martina Vetro, Lucia Anna Stivala, Carlo Ganini, Marta Cancelliere, Massimo Zucchetti, Isabella Guardamagna, and Maristella Maggi

Subjects
Asparaginase, Cell cycle, Adenocarcinoma, Solid tumors, Renal cell carcinoma, Breast carcinoma, Science (General), Q1-390, Social sciences (General), H1-99
Abstract

Asparagine and glutamine depletion operated by the drug Asparaginase (ASNase) has revolutionized therapy in pediatric patients affected by Acute Lymphoblastic Leukemia (ALL), bringing remissions to a remarkable 90 % of cases. However, the knowledge of the proproliferative role of asparagine in adult and solid tumors is still limited. We have here analyzed the effect of ASNase on three adenocarcinoma cell lines (A549, lung adenocarcinoma, MCF-7, breast cancer, and 786-O, kidney cancer). In contrast to MCF-7 cells, 786-O and A549 cells proved to be a relevant target for cell cycle perturbation by asparagine and glutamine shortage. Indeed, when the cell-cycle was analyzed by flow cytometry, A549 showed a canonical response to asparaginase, 786-O cells, instead, showed a reduction of the percentage of cells in the G1 phase and an increase of those in the S-phase. Despite an increased number of PCNA and RPA70 positive nuclear foci, BrdU and EdU incorporation was absent or strongly delayed in treated 786-O cells, thus indicating a readiness of replication forks unmatched by DNA synthesis. In 786-O asparagine synthetase was reduced following treatment and glutamine synthetase was totally absent. Interestingly, DNA synthesis could be recovered by adding Gln to the medium. MCF-7 cells showed no significant changes in the cell cycle phases, in DNA-bound PCNA and in total PCNA, but a significant increase in ASNS and GS mRNA and protein expression. The collected data suggest that the effect observed on 786-O cells following ASNase treatment could rely on mechanisms which differ from those well-known and described for leukemic blasts, consisting of a complete block in the G1/S transition in proliferating cells and on an increase on non-proliferative (G0) blasts.

Published
2024
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32. A high-throughput approach to identify BRCA1-downregulating compounds to enhance PARP inhibitor sensitivity

Author

Erin Sellars, Margarita Savguira, Jie Wu, Sabrina Cancelliere, Mark Jen, Rehna Krishnan, Anne Hakem, Dalia Barsyte-Lovejoy, Razqallah Hakem, Steven A. Narod, Joanne Kotsopoulos, and Leonardo Salmena

Subjects
Pharmacology, Cell biology, Cancer, Science
Abstract

Summary: PARP inhibitors (PARPi) are efficacious in BRCA1-null tumors; however, their utility is limited in tumors with functional BRCA1. We hypothesized that pharmacologically reducing BRCA1 protein levels could enhance PARPi effectiveness in BRCA1 wild-type tumors. To identify BRCA1 downregulating agents, we generated reporter cell lines using CRISPR-mediated editing to tag endogenous BRCA1 protein with HiBiT. These reporter lines enable the sensitive measurement of BRCA1 protein levels by luminescence. Validated reporter cells were used in a pilot screen of epigenetic-modifying probes and a larger screen of more than 6,000 compounds. We identified 7 compounds that could downregulate BRCA1-HiBiT expression and synergize with olaparib. Three compounds, N-acetyl-N-acetoxy chlorobenzenesulfonamide (NANAC), A-443654, and CHIR-124, were validated to reduce BRCA1 protein levels and sensitize breast cancer cells to the toxic effects of olaparib. These results suggest that BRCA1-HiBiT reporter cells hold promise in developing agents to improve the clinical utility of PARPi.

Published
2024
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33. BRCA-associated hereditary male cancers: can gender affect the prevalence and spectrum of germline pathogenic variants?

Author

Daniele Fanale, Lidia Rita Corsini, Chiara Brando, Ugo Randazzo, Marco Bono, Erika Pedone, Alessandro Perez, Roberta Sciacchitano, Daniela Cancelliere, Paola Piraino, Ambra Giurintano, Tancredi Didier Bazan Russo, Pietro Ferraro, Gaetana Rinaldi, Valeria Spinnato, Vincenzo Gennusa, Gianfranco Pernice, Salvatore Vieni, Gianni Pantuso, Antonio Russo, and Viviana Bazan

Subjects
BRCA1, BRCA2, germline pathogenic variants, HBOC, male breast cancer, melanoma, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

IntroductionAlthough hereditary male neoplasms are quite rare, individuals harbouring germline BRCA1/2 pathogenic variants (PVs) may have a risk of developing tumours associated with Hereditary Breast and Ovarian Cancer (HBOC) syndrome, including male breast (MBC), prostate (PCa) and pancreatic (PC) cancers, and melanoma. Women and men showed a comparable genetic architecture of cancer susceptibility, but there are some gender-specific features. Since little is known about cancer genetic susceptibility in male population, our study was aimed at investigating the frequency of BRCA1/2 PVs in men with HBOC syndrome-associated tumors, in order to understand whether differences in gender may reflect in the prevalence and spectrum of germline alterations.Patients and methodsWe retrospectively collected and analysed clinical information of 352 HBOC-associated male cancer patients genetically tested for germline BRCA1/2 PVs by Next-Generation Sequencing analysis, enrolled, from February 2018 to January 2024, at the “Regional Center for the prevention, diagnosis and treatment of rare and heredo-familial tumors of adults” of the University-Hospital Policlinico “P. Giaccone” of Palermo (Italy).ResultsOur investigation revealed that 7.4% of patients was carrier of a germline BRCA PV, with an almost total prevalence of BRCA2 alterations. In particular, 65.4% of BRCA-positive patients developed MBC, 19.2% had PC, 11.6% developed PCa, and only 3.8% had melanoma. Specifically, MBC individuals showed a BRCA-associated genetic predisposition in 17% of cases, whereas patients with PCa or PC exhibited a lower frequency of BRCA2 PVs, taking into account the current national criteria for access to germline genetic testing.DiscussionOur study showed a high heterogeneity in prevalence of germline BRCA2 PVs among men which could reflect a potential gender-specific genetic heterogeneity. Therefore, BRCA-associated male tumours could be due to BRCA2 PVs different from those usually detected in women. In the event that it is demonstrated, in future, that male cancers are genetically distinct entities from those female this could improve personalized risk evaluation and guide therapeutic choices for patients of both sexes, in order to obtain a gender equality in cancer care.

Published
2024
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36. Evaluation of an Enzyme-Linked Magnetic Electrochemical Assay for Hepatitis a Virus Detection in Drinking and Vegetable Processing Water

Author

Cristine D’Agostino, Rocco Cancelliere, Antonio Ceccarelli, Danila Moscone, Loredana Cozzi, Giuseppina La Rosa, Elisabetta Suffredini, and Laura Micheli

Subjects
HAV, ELIME, screen-printed electrodes, drinking water, vegetable processing water, Biochemistry, QD415-436
Abstract

Globally, waterborne viral infections significantly threaten public health. While current European Union regulations stipulate that drinking water must be devoid of harmful pathogens, they do not specifically address the presence of enteric viruses in water used for irrigation or food production. Traditional virus detection methods rely on molecular biology assays, requiring specialized personnel and laboratory facilities. Here, we describe an electrochemical sandwich enzyme-linked immunomagnetic assay (ELIME) for the detection of the hepatitis A virus (HAV) in water matrices. This method employed screen-printed electrodes as the sensing platform and utilized commercially available pre-activated magnetic beads to provide a robust foundation for the immunological reaction. The ELIME assay demonstrated exceptional analytical performance in only 185 min achieving a detection limit of 0.5 genomic copies per milliliter (g.c./mL) and exhibiting good reproducibility with a relative standard deviation (RSD) of 7% in HAV-spiked drinking and processing water samples. Compared with the real-time RT-qPCR method described in ISO 15216-1, the ELIME assay demonstrated higher sensitivity, although the overall linearity of the method was moderate. These analytical attributes highlight the potential of the ELIME assay as a rapid and viable alternative for HAV detection in water used for agriculture and food processing.

Published
2024
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37. Care at a distance: Understanding lived experiences of people with MSK disorders receiving non-pharmacological interventions delivered through synchronous telehealth: A systematic rapid review

Author

Melissa Atkinson-Graham, Ginny Brunton, Carol Cancelliere, Melissa Corso, Annemarie de Zoete, Sidney M Rubinstein, Kent Murnaghan, and Silvano Mior

Subjects
Computer applications to medicine. Medical informatics, R858-859.7
Abstract

Background Little is known about lived experience of synchronous telehealth in patients with musculoskeletal (MSK) disorders. Objective We conducted a rapid systematic review to answer: (1) what are the lived experiences and/or perspectives of people with MSK disorders receiving non-pharmacological interventions delivered through synchronous telehealth; and (2) what clinical implications can be inferred from qualitative studies focusing on lived experiences for how telehealth is delivered in the management of MSK disorders? Data sources A comprehensive search of MEDLINE, CINAHL, PsycINFO, ProQuest, and Google Scholar from June 2010 to July 2023. Eligible qualitative and mixed methods studies capturing lived experiences of adults with MSK disorders receiving non-pharmacological interventions via synchronous telehealth were included. Study methods Systematic rapid review conducted according to WHO guidelines. Titles and abstracts screened by reviewers independently, eligible studies critically appraised, and data was extracted. Themes summarized using the Consolidated Framework for Implementation Research (CFIR). GRADE-CERQual (Confidence in the Evidence from Reviews of Qualitative research) used to assess confidence in synthesis findings. Results We identified 9782 references, screened 8029, and critically appraised 22, and included 17 studies. There is evidence to suggest that the experience of telehealth prior to and during the pandemic was shaped by (1) patient perception of telehealth, (2) existing relationships with practitioners, (3) availability and accessibility of telehealth technologies, and (4) perceptions about the importance of the role of the physical exam in assessing and treating MSK disorders. Conclusion The five identified implications could be used to inform future research, policy, and strategy development.

Published
2024
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39. Effectiveness of postsurgical rehabilitation following lumbar disc herniation surgery: A systematic review

Author

Yu, Hainan, Cancelliere, Carol, Mior, Silvano, Pereira, Paulo, Nordin, Margareta, Brunton, Ginny, Wong, Jessica J., Shearer, Heather M., Connell, Gaelan, Ead, Lauren, Verville, Leslie, Rezai, Mana, Myrtos, Danny, Wang, Dan, Marchand, Andrée-Anne, Romanelli, Andrew, Germann, Darrin, To, Daphne, Young, James J., Southerst, Danielle, Candelaria, Henry, Hogg-Johnson, Sheilah, and Côté, Pierre

Published
2024
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40. Clinical relevance of exosome-derived microRNAs in Ovarian Cancer: Looking for new tumor biological fingerprints

Author

Fanale, Daniele, Corsini, Lidia Rita, Bono, Marco, Randazzo, Ugo, Barraco, Nadia, Brando, Chiara, Cancelliere, Daniela, Contino, Silvia, Giurintano, Ambra, Magrin, Luigi, Pedone, Erika, Perez, Alessandro, Piraino, Paola, Pivetti, Alessia, Giovanni, Emilia Di, Russo, Tancredi Didier Bazan, Prestifilippo, Ornella, Gennusa, Vincenzo, Pantuso, Gianni, Russo, Antonio, and Bazan, Viviana

Published
2024
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41. Management of Adult Unruptured Brain Arteriovenous Malformations: An Updated Network Meta-Analysis

Author

Adam A. Dmytriw, Jerry Ku, Sherief Ghozy, Sahibjot Grewal, Nicole M. Cancelliere, Ahmed Y. Azzam, Robert W. Regenhardt, James D. Rabinov, Christopher J. Stapleton, Krunal Patel, Aman B. Patel, Vitor Mendes Pereira, and Michael Tymianski

Subjects
arteriovenous malformation, a randomized trial of unruptured brain arteriovenous malformations, neurosurgery, Medicine (General), R5-920, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

The management of unruptured brain arteriovenous malformations (ubAVMs) is a complex challenge to neurovascular practitioners. This meta-analysis aimed to identify the optimal management of ubAVMs comparing conservative management, embolization, radiosurgery, microsurgical resection, and multimodality. The search strategy was developed a priori according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We searched the Ovid Medline, Embase, Web of Science, and Cochrane Library databases to identify relevant papers. Using R version 4.1.1., a frequentist network meta-analysis was conducted to compare different management modalities for the ubAVMs. Overall, the conservative group had the lowest risk of rupture (P-score=0.77), and the lowest rate of complications was found in the conservative group (P-score=1). Among different interventions, the multimodality group had the highest rupture risk (P-score=0.34), the lowest overall complications (P-score=0.75), the best functional improvement (P-score=0.65), and the lowest overall mortality (P-score=0.8). However, multimodality treatment showed a significantly higher risk of rupture (odds ratio [OR]=2.13; 95% confidence interval [95% CI]=1.18–3.86) and overall complication rate (OR=5.56; 95% CI=3.37–9.15) compared to conservative management; nevertheless, there were no significant differences in overall mortality or functional independence when considered independently. Conservative management is associated with the lowest rupture risk and complication rate overall. A multimodal approach is the best option when considering mortality rates and functional improvement in the context of existing morbidity/symptoms. Microsurgery, embolization, and radiosurgery alone are similar to the natural history in terms of functional improvement and mortality, but have higher complication rates.

Published
2023
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42. Theranostic biomarkers and PARP-inhibitors effectiveness in patients with non-BRCA associated homologous recombination deficient tumors: Still looking through a dirty glass window?

Author

Incorvaia, Lorena, Perez, Alessandro, Marchetti, Claudia, Brando, Chiara, Gristina, Valerio, Cancelliere, Daniela, Pivetti, Alessia, Contino, Silvia, Di Giovanni, Emilia, Barraco, Nadia, Bono, Marco, Giurintano, Ambra, Bazan Russo, Tancredi Didier, Gottardo, Andrea, Cutaia, Sofia, Pedone, Erika, Peri, Marta, Corsini, Lidia Rita, Fanale, Daniele, Galvano, Antonio, Scambia, Giovanni, Badalamenti, Giuseppe, Russo, Antonio, and Bazan, Viviana

Published
2023
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48. Using principal component analysis to incorporate multi-layer soil moisture information in hydrometeorological thresholds for landslide prediction: an investigation based on ERA5-Land reanalysis data

Author

N. Palazzolo, D. J. Peres, E. Creaco, and A. Cancelliere

Subjects
Environmental technology. Sanitary engineering, TD1-1066, Geography. Anthropology. Recreation, Environmental sciences, GE1-350, Geology, QE1-996.5
Abstract

A key component for landslide early warning systems (LEWSs) is constituted by thresholds providing the conditions above which a landslide can be triggered. Traditionally, thresholds based on rainfall characteristics have been proposed, but recently, the hydrometeorological approach, combining rainfall with soil moisture or catchment storage information, is becoming widespread. Most of the hydrometeorological thresholds proposed in the literature use the soil moisture from a single layer (i.e., depth or depth range). On the other hand, multi-layered soil moisture information can be measured or can be available from reanalysis projects as well as from hydrological models. Approaches using this multi-layered information are lacking, perhaps because of the need to keep the thresholds simple and two-dimensional. In this paper, we propose principal component analysis (PCA) as an approach for deriving two-dimensional hydrometeorological thresholds that use multi-layered soil moisture information. To perform a more objective assessment we also propose a piecewise linear equation for the identification of the threshold's shape, which is more flexible than traditional choices (e.g., power law or bilinear). Comparison of the receiver operating characteristic (ROC) (true skill statistic, TSS) of thresholds based on single- and multi-layered soil moisture information also provides a novel tool for identifying the significance of multi-layered information on landslide triggering in a given region. Results for Sicily island, considering the ERA5-Land reanalysis soil moisture data (available at four different depth layers), corroborate the advantages of the hydrometeorological approach gained in spite of the coarse spatial resolution and the limited accuracy of reanalysis data. Specifically, the TSS of traditional precipitation intensity–duration thresholds is equal to 0.5, while those of the proposed hydrometeorological thresholds is significantly higher (TSS=0.71). For the analyzed region, however, multi-layered information seems not to be relevant, as performances in terms of TSS are similar to those obtained with single-layer soil moisture at the upper depths, namely 0–7 and 7–28 cm, which can imply that in Sicily landslide phenomena are mainly influenced by soil moisture in most shallow soil layers.

Published
2023
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49. An Intelligent Hierarchical Cyber-Physical System for Beach Waste Management: The BIOBLU Case Study

Author

Giovanni Cicceri, Dario C. Guastella, Giuseppe Sutera, Francesco Cancelliere, Mario Vitti, Giovanni Randazzo, Salvatore DiStefano, and Giovanni Muscato

Subjects
Intelligent cyber-physical systems, multi-robot systems, unmanned aerial vehicles, computer vision, unmanned ground vehicles, beach waste management, Electrical engineering. Electronics. Nuclear engineering, TK1-9971
Abstract

Nestled at the confluence of nature grandeur and human civilization, beaches command an influential presence that resonates throughout the environment, society, and culture. However, climate change and pollution overhang the beach health and need to be properly dealt with. Proactive measures involve education, responsible waste management, sustainable infrastructure, and environmental regulations, while reactive ones focus on immediate response and cleanup efforts. Nevertheless, continuous monitoring and cleaning are challenging due to various factors such as beach characteristics, hidden waste, weather conditions and, consequently, high costs. To overcome such challenges, this paper proposes an autonomous system for beach cleaning adopting an Intelligent Hierarchical Cyber-Physical System (IHCPS) approach and Information and Communication Technologies. The proposed beach waste management (BeWastMan) solution integrates an Unmanned Aerial Vehicle for the beach aerial surveillance and monitoring, a ground station for data processing, and an Unmanned Ground Vehicle to collect and sort waste autonomously. The research findings contribute to the development of innovative and fully automated approaches in beach waste management, and demonstrate the feasibility and effectiveness of the BeWastMan IHCPS by a real case study, developed in the frame of the BIOBLU project.

Published
2023
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50. Label-free electrochemical immunosensor as a reliable point-of-care device for the detection of Interleukin-6 in serum samples from patients with psoriasis

Author

Rocco Cancelliere, Terenzio Cosio, Elena Campione, Martina Corvino, Maria Pia D’Amico, Laura Micheli, Emanuela Signori, and Giorgio Contini

Subjects
interleukin-6, sandwich-based immunosensor, biochar, serum samples, psoriasis, point-ofcare, Chemistry, QD1-999
Abstract

Interleukin-6 (IL-6) plays a crucial role in autoimmunity and chronic inflammation. This study aims to develop a low-cost, simple-to-manufacture, and user-friendly label-free electrochemical point-of-care device for the rapid detection of IL-6 in patients with psoriasis. Precisely, a sandwich-based format immunosensor was developed using two primary antibodies (mAb-IL6 clone-5 and clone-7) and screen-printed electrodes modified with an inexpensive recycling electrochemical enhancing material, called biochar. mAb-IL6 clone-5 was used as a covalently immobilized capture bioreceptor on modified electrodes, and mAb-IL6 clone-7 was used to recognize the immunocomplex (Anti-IL6 clone-5 and IL-6) and form the sandwich. Cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were used to conduct electrochemical characterization of the layer-by-layer assembly of the immunosensor, while square wave voltammetry (SWV) was used to perform the sensing. The developed immunosensor demonstrated robust analytical performance in buffer solution, with a wide linear range (LR) by varying from 2 to 250 pg/mL, a good limit of detection (LOD) of 0.78 pg/mL and reproducibility (RSD

Published
2023
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