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Introduction: Walking stands as the most prevalent physical activity in the daily lives of individuals and is closely associated with physical functioning and the aging process. Nonetheless, the precise cause-and-effect connection between walking and aging remains unexplored. The epigenetic clock emerges as the most promising biological indicator of aging, capable of mirroring the biological age of the human body and facilitating an investigation into the association between walking and aging. Our primary objective is to investigate the causal impact of walking with epigenetic age acceleration (EAA). Methods: We conducted a two-sample two-way Mendelian randomization (MR) study to investigate the causal relationship between walking and EAA. Walking and Leisure sedentary behavior data were sourced from UK Biobank, while EAA data were gathered from a total of 28 cohorts. The MR analysis was carried out using several methods, including the inverse variance weighted (IVW), weighted median, MR-Egger, and robust adjusted profile score (RAPS). To ensure the robustness of our findings, we conducted sensitivity analyses, which involved the MR-Egger intercept test, Cochran's Q test, and MR-PRESSO, to account for and mitigate potential pleiotropy. Results: The IVW MR results indicate a significant impact of usual walking pace on GrimAge (BETA = − 1.84, 95% CI (− 2.94, − 0.75)), PhenoAge (BETA = − 1.57, 95% CI (− 3.05, − 0.08)), Horvath (BETA = − 1.09 (− 2.14, − 0.04)), and Hannum (BETA = − 1.63, 95% CI (− 2.70, − 0.56)). Usual walking pace is significantly associated with a delay in epigenetic aging acceleration (EAA) (P < 0.05). Moreover, the direction of effect predicted by the gene remained consistent across RAPS outcomes and sensitivity MR analyses. There is a lack of robust causal relationships between other walking conditions, such as walking duration and walking frequency, on EAA (P > 0.05). Conclusion: Our evidence demonstrates that a higher usual walking pace is associated with a deceleration of the acceleration of all four classical epigenetic clocks acceleration. Key messages: In recent years, observational studies have found that there is a correlation between walking and aging, but the specific relationship is not clear We used a Mendelian randomization approach to test the causal effect of walking and sedentarism on epigenetic clock acceleration Mendelian randomization studies have found that faster walking speed may delay physiological aging through causal analysis at the genetic level [ABSTRACT FROM AUTHOR]

Background: Requirements of blood transfusions rise rapidly in China. Improving the efficiency of blood donation could help maintaining sufficient blood supplement. We conducted a pilot research to investigate the reliability and safety of collecting more units of red blood cell by apheresis. Methods: Thirty‐two healthy male volunteers were randomized into two groups: red blood cell apheresis (RA) (n = 16) and whole blood (WB) donation (n = 16). RA group donated individualized RBC volumes by apheresis according to the volunteers' basal total blood volumes and haematocrit levels, WB group donated 400 mL whole blood. All volunteers were scheduled seven visit times in 8 weeks' study period. The cardiovascular functions were assessed by laboratory examinations, echocardiography and cardiopulmonary functional tests. All results were compared between groups at the same visit time and compared between visit 1(before donation) and other visit times within the same group. Results: The average donated RBC volume in RA group and in WB group was 627.25 ± 109.74 mL and 175.28 ± 8.85 mL, respectively(p < 0.05); the RBC, haemoglobin and haematocrit levels changed significantly between times and between groups (p < 0.05). Cardiac biomarker levels such as NT‐proBNP, hs‐TnT and CK‐MB did not change significantly between times or between groups (p > 0.05). The echocardiographic and cardiopulmonary results did not change significantly between times or between groups during the whole study period(p > 0.05). Conclusions: We provided an efficient and secure method for RBC apheresis. By harvesting more RBC volumes at one single‐time, the cardiovascular functions did not change significantly compared with traditional whole blood donation. [ABSTRACT FROM AUTHOR]

Background: Music intervention can reduce anxiety. This study analyzed the physiological changes from using music intervention after cardiothoracic surgery. Methods: Subjects were randomly assigned to the music group or the control group. The maximal inspiratory pressure/maximal expiratory pressure (MIP/MEP), pulse oximeter oxygen saturation (SpO2), visual analogue scale (VAS) for pain, and State-Trait Anxiety Inventory (STAI) were compared. Results: Compared to the control group (n = 9), the music group (n = 9) had higher MIP and MEP during the overall test (p < 0.05), with significant differences in the changes and time (p < 0.001). However, only MEP was significant in terms of the interaction between music intervention and time (p < 0.001). In terms of the groups, SpO2 and VAS were significant (p < 0.05). SBP, SpO2, and VAS over time showed significant differences between the two groups (p < 0.05). In terms of the interaction between music intervention and time, only SpO2 was significant (p < 0.05). The STAI-S scale decreased by −5.7 ± 5.8 in the music group vs. −0.47 ± 9.37 in control group and the STAI-T scale increased by 4.17 ± 12.31 in the music group vs. 1.9 ± 9.29 in the control group, but showed no significance. Conclusions: Music intervention with nature sounds has a positive physiological impact and can reduce postoperative pain and anxiety in cardiothoracic surgery patients. [ABSTRACT FROM AUTHOR]

This paper investigates a dynamic 3D trajectory design of multiple cache-enabled unmanned aerial vehicles (UAVs) in a wireless device-to-device (D2D) caching network with the goal of maximizing the long-term network throughput. By storing popular content at the nearby mobile user devices, D2D caching is an efficient method to improve network throughput and alleviate backhaul burden. With the attractive features of high mobility and flexible deployment, UAVs have recently attracted significant attention as cache-enabled flying base stations. The use of cache-enabled UAVs opens up the possibility of tracking the mobility pattern of the corresponding users and serving them under limited cache storage capacity. However, it is challenging to determine the optimal UAV trajectory due to the dynamic environment with frequently changing network topology and the coexistence of aerial and terrestrial caching nodes. In response, we propose a novel multi-agent reinforcement learning based framework to determine the optimal 3D trajectory of each UAV in a distributed manner without a central coordinator. In the proposed method, multiple UAVs can cooperatively make flight decisions by sharing the gained experiences within a certain proximity to each other. Simulation results reveal that our algorithm outperforms the traditional single- and multi-agent Q-learning algorithms. This work confirms the feasibility and effectiveness of cache-enabled UAVs which serve as an important complement to terrestrial D2D caching nodes. [ABSTRACT FROM AUTHOR]

A large number of instability cases and laboratory tests of expansive soil slopes show that its shallow layer destruction happens because of the insufficient shear strength under the usual action of low stress and repeated dry-wet cycles. We can obtain the strength nonlinear distribution law fitted by generalized power function based on a series of shear strength tests of expansive soil considering low stress and can construct the numerical model considering the nonlinear strength distribution by FISH, to realize the shear strength dynamic distribution with the vertical stress. Based on the numerical model, the whole-process contrastive analysis has been conducted on the stress field, the slip surface depth, and the seepage field of plain soil and reinforced expansive soil cut slope under different rainfall conditions. Besides, the mechanics characteristic of the geogrid under various design schemes has been compared and analyzed. A further explanation has been given for the expansive soil cut slope prone to shallow layer failure after rainfall and on the effect of geogrid reinforcement. The numerical results provide a reference for slope stability analysis in rainy expansive soil areas. [ABSTRACT FROM AUTHOR]

We investigate the ionospheric responses to the 2014–2015 sudden stratospheric warming (SSW) event in winter and summer hemisphere by using ionosondes distributed in Equatorial Ionization Anomaly (EIA) crests. Daily mean value of foF2 at each station shows obvious semimonthly lunar tide (∼14.5‐day period) modulation from lower to higher latitude in both hemispheres during SSW period. Besides, lunar tide modulation in summer hemisphere is later than that in winter hemisphere, which can be explained by the planetary wave penetrating across the equator from winter to summer hemisphere. In addition, lunar semidiurnal tide extracted from foF2 presents evident enhancement after warming onset. Our results demonstrate the quasi 16‐day periodic oscillations in F region of EIA crests are caused by the enhanced lunar tide in dynamo wind of mesosphere and lower thermosphere region, which is due to the disturbances in the zonal mean wind distribution in connection with SSW.Plain Language Summary: The sudden stratospheric warming (SSW) is a large‐scale meteorological event in the winter polar stratosphere, and the connection between SSW and ionosphere variability is now well established observationally, however, the mechanisms responsible for generating the ionosphere disturbances remains an active area of research. In this study, we try to investigate the lunar tide modulation in ionospheric Equatorial Ionization Anomaly crest in both hemispheres and its latitudinal dependence during a minor SSW event. We analyze the possible mechanism for explaining the enhanced lunar modulation which occurs successively from lower to higher latitude.Key Points: Semimonthly lunar tide modulation in foF2 occurs in sequence from lower to higher latitude in Equatorial Ionization Anomaly crest of both hemispheres during sudden stratospheric warming (SSW)The peak of quasi 16‐day oscillation in foF2 also appears from lower to higher latitude in both hemispheres in sequenceLunar effect on foF2 in winter hemisphere is earlier than that in summer hemisphere during SSW [ABSTRACT FROM AUTHOR]

In the present study, a highly efficient CaO-based catalyst was synthesized by using abalone shell as a precursor and ethanol as a modification agent for biodiesel production. The physico/chemical properties of the catalysts, which could be tailored by altering the ethanol-treatment temperature (room temperature, 100 °C and 160 °C), were monitored by X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer–Emmett–Teller (BET) analysis and Hammett indicator. Once treated with ethanol, the modified CaO (M-CaO) catalyst exhibited an increased catalytic activity mainly due to the high surface area, increased specific basicity and decreased crystalline size compared to the unmodified CaO (U-CaO) catalyst. Particularly, when the ethanol treatment temperature was 100 °C, the maximal yield of fatty acid methyl ester (FAME) for the M-CaO catalyst could reach 96.2% (87.5% for the U-CaO catalyst). Furthermore, the M-CaO catalyst exhibited good reusability, having a superior catalytic activity compared to the U-CaO catalyst after recycling for more than five cycles. [ABSTRACT FROM AUTHOR]

In the present study, rice husk ash (RHA, a solid waste from agriculture) was served as the support for loading calcined eggshell (another material derived from waste source) to prepare solid base catalyst. This catalyst was then applied for catalytically converting palm oil into biodiesel. The effects of catalyst preparation conditions (such as rice husk treatment temperature, the loading of calcined eggshell on the RHA, and the calcination temperature of eggshell-loaded RHA), reaction conditions (such as reaction time, methanol-to-oil molar ratio and catalyst loading) and the catalyst reusability were carefully studied. The experimental results revealed that 30% RHA 800 -800 exhibited the highest catalytic activity. More specifically, when the reaction was carried out with a reaction time of 4 h, methanol-to-oil molar ratio of 9:1, and catalyst loading of 7 wt.%, the biodiesel yield could reach 91.5%. Besides, after reused for more than 8 cycles, the catalyst could still possess a rather high biodiesel yield (above 80%). [ABSTRACT FROM AUTHOR]

Microbial fuel cells (MFCs) are devices that exploit microorganisms as biocatalysts to degrade organic matter or sludge present in wastewater (WW), and thereby generate electricity. We developed a simple, low-cost single-chamber microbial fuel cell (SCMFC)-type biochemical oxygen demand (BOD) sensor using carbon felt (anode) and activated sludge, and demonstrated its feasibility in the construction of a real-time BOD measurement system. Further, the effects of anodic pH and organic concentration on SCMFC performance were examined, and the correlation between BOD concentration and its response time was analyzed. Our results demonstrated that the SCMFC exhibited a stable voltage after 132 min following the addition of synthetic WW (BOD concentration: 200 mg/L). Notably, the response signal increased with an increase in BOD concentration (range: 5-200 mg/L) and was found to be directly proportional to the substrate concentration. However, at higher BOD concentrations (>120 mg/L) the response signal remained unaltered. Furthermore, we optimized the SCMFC using synthetic WW, and tested it with real WW. Upon feeding real WW, the BOD values exhibited a standard deviation from 2.08 to 8.3% when compared to the standard BOD5 method, thus demonstrating the practical applicability of the developed system to real treatment effluents.