35 results on '"Aydın, Emre"'
Search Results
2. Clinical and histopathological characteristics of primary focal segmental glomerulosclerosis in Turkish adults
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Kurultak, Ilhan, Gungor, Ozkan, Ozturk, Savas, Dirim, Ahmet Burak, Eren, Necmi, Yenigün, Ezgi, Dal, Elbis Ahbab, Dincer, Mevlut Tamer, Bora, Feyza, Akgur, Suat, Sumnu, Abdullah, Dursun, Belda, Sipahi, Savas, Cetinkaya, Hakki, Sahin, Idris, Sahin, Garip, Yilmaz, Murvet, Vatansever, Bulent, Aydın, Emre, Ulu, Memnune Sena, Gundogdu, Ali, Ustundag, Sedat, Sayarlioglu, Hayriye, Kumru, Gizem, Elcioglu, Omer C., Aydın, Zeki, Selcuk, Nedim Yılmaz, Onal Guclu, Ceren, Oruc, Meric, Kucuk, Mehmet, Aktas, Nimet, Derici, Ulver, and Suleymanlar, Gultekin
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- 2024
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3. Comparison of choroidal thickness, superficial and deep retinal vascular indices, and foveal avascular zones: Martial arts athletes vs healthy non-athletes
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Genç, Çiğdem Deniz, Yılmaz, Ali Kerim, Kurt, Muhammed Mustafa, Özgür, Gökhan, Aydın, Emre, and Yılmaz, Coşkun
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- 2024
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4. Left ventricular global longitudinal strain can detect subclinical left ventricular systolic dysfunction in adult patients with primary nephrotic syndrome
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Çap, Neşe Kanbal, Aydın, Emre, Kadiroğlu, Ali Kemal, Özbek, Mehmet, Yıldırım, Yaşar, Yılmaz, Zülfikar, Aydın, Fatma Yılmaz, and Çap, Murat
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- 2023
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5. Evaluation of whole blood thiamine pyrophosphate concentrations in critically ill patients receiving chronic diuretic therapy prior to admission to Turkish intensive care units: A pragmatic, multicenter, prospective study
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Gundogan, Kursat, Sahin, Gulsah G., Ergul, Serap S., Ozer, Nurhayat T., Temel, Sahin, Akbas, Turkay, Ercan, Talha, Yildiz, Hamit, Dizdar, Oguzhan S., Simsek, Zuhal, Aydın, Kaniye, Ulu, Ramazan, Zerman, Avsar, Dal, Hayriye C., Aydin, Emre, Ozyilmaz, Ezgi, Ateş, Nazire, Gonderen, Kamil, Yalcin, Nazif, Topeli, Arzu, Tok, Gulay, Edipoglu, Ozlem, Ergan, Begum, Aydemir, Ferhan D., Akbudak, Ismail H., Ergun, Recai, Yuksel, Recep C., Sungur, Murat, Griffith, Daniel P., and Ziegler, Thomas R.
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- 2023
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6. Performance models of passenger aircraft and propulsion systems based on particle swarm and Spotted Hyena Optimization methods
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Aydın, Emre and Turan, Onder
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- 2023
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7. Clinical predictors of incipient vertebral fractures and bone mineral density in kidney transplant patients
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Gogas Yavuz, Dilek, Aydin, Kadriye, Apaydin, Tugce, Velioglu, Arzu, Mert, Meral, Pekkolay, Zafer, Parmaksiz, Ergun, Mese, Meral, Esen Pazir, Ayse, Aydın, Emre, Bugdayci, Onur, and Tuglular, Serhan
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- 2022
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8. Preschoolers’ learning of information from fantastical narrative versus expository books
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Aydin, Emre, Ilgaz, Hande, and Allen, Jedediah W.P.
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- 2021
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9. The efficiency and safety of oxygen-supplemented accelerated transepithelial corneal cross-linking
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Aydın, Emre and Aslan, Mehmet Gökhan
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- 2021
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10. Could the appropriate anti-diabetic therapy be mixed insulin in dialysis patients?
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Demircan, Vehbi, Yıldırım, Yaşar, Aydın, Emre, Kara, Ali Veysel, Aydın, Fatma Yılmaz, Yılmaz, Zülfükar, Kadiroğlu, Ali Kemal, Tuzcu, Alpaslan Kemal, and Pekkolay, Zafer
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- 2021
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11. The impact of hybrid contact lenses on keratoconus progression after accelerated transepithelial corneal cross-linking
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Aslan, Mehmet Gökhan, Fındık, Hüseyin, Okutucu, Murat, Aydın, Emre, and Uzun, Feyzahan
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- 2021
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12. Characteristics and outcomes of critically ill injured patients admitted to intensive care units after the earthquake in Southeast Turkiye: Multicenter retrospective analysis
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Kaya, Esat Kivanc, Guven, Goksel, Yildirim, Mehmet, Seven, Asir Eren, Yuksel, Recep Civan, Bulut, Kadir, Gulen, Derful, Yuksel, Nihal Deniz Bulut, Kocak, Gamze, Deveci, Kamil, Mendil, Nilgun Alptekinoglu, Elay, Gulseren, Sullu, Begum Erdemir, Kilicaslan, Banu, Akinci, Seda Banu, Aydin, Emre, Kaynar, Ahmet Safa, Temel, Sahin, Halacli, Burcin, Ersoy, Nazmiye Ebru Ortac, Ulger, Birkan, Coruh, Aliye Esmaoglu, Dundar, Nazlihan Boyaci, Sungur, Murat, Gundogan, Kursat, and Topeli, Arzu
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- 2024
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13. Serum 25-Hydroxy Vitamin D, Vitamin B12, and Folic Acid Levels in Progressive and Nonprogressive Keratoconus
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Aslan, Mehmet Gökhan, Fındık, Hüseyin, Okutucu, Murat, Aydın, Emre, Oruç, Yavuz, Arpa, Medeni, and Uzun, Feyzahan
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- 2020
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14. Fast Multiplier Generator for FPGAs with LUT based Partial Product Generation and Column/row Compression
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Kakacak, Ahmet, Guzel, Aydin Emre, Cihangir, Ozan, Gören, Sezer, and Ugurdag, H. Fatih
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- 2017
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15. Evaluation of fluid status related parameters in hemodialysis and peritoneal dialysis patients: Clinical usefulness of bioimpedance analysis
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Yılmaz, Zülfükar, Yıldırım, Yaşar, Aydın, Fatma Yılmaz, Aydın, Emre, Kadiroğlu, Ali Kemal, Yılmaz, Mehmet Emin, and Acet, Halit
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- 2014
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16. Management of side branch stenosis with pre-dilatation in coronary bifurcation disease.
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Çörekçioğlu, Büşra, Aydın, Emre, Aydın, Merve, Uysal, Hande, Güner, Ahmet, and Uzun, Fatih
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- 2024
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17. Frequency and relationship of ABO blood groups in patients with nephrotic syndrome.
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Oruç, İdris, Sarı, Hıdır, Araç, Songül, Eynel, Eren, Pekkolay, Zafer, Kadiroğlu, Ali Kemal, Yılmaz, Zülfikar, Aydın, Fatma Yılmaz, Aydın, Emre, and Yıldırım, Yaşar
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ABO blood group system ,NEPHROTIC syndrome diagnosis ,PROTEINURIA ,GLOMERULOSCLEROSIS ,DATA analysis - Abstract
Aim of the study: To investigate the frequency of ABO blood groups and the relationship between nephrotic syndrome (NS) and blood groups in patients with NS. Material and methods: 199 patients with a diagnosis of NS and 200 healthy individuals, who applied to Dicle University Faculty of Medicine, Department of Nephrology between 2016 and 2020, and whose blood group information was in the records, were included in the study as the control group. This study was carried out retrospectively using data from the file registration system in our hospital. Results: In the study, there were 199 patients: 52.8% (n = 105) male and 47.2% (n = 94) female and 200 healthy individuals: 47.5% male (n = 95) 52.5% female (n = 105). The mean age of the patients was 35.79 ± 12.21 (min-max: 17-71), and the mean proteinuria was 7.08 ± 4.33 (min-max: 3.50-25.50). There was no difference between sick and healthy individuals in terms of age or sex (p > 0.05). It was determined that 43.2% of the patients had blood group A, 26.1% blood group O, 25.1% blood group B, and 5.5% blood group AB. There was no significant difference between blood groups of patients with NS and individuals in the healthy group (p > 0.05). Membranous glomerulonephritis (MGN) (27.9%) was most common in blood group A; FSGS was detected most frequently in blood groups B (46.0%), O (28.8%), and AB (36.4%). The most common cause of NS was focal segmental glomerulosclerosis (FSGS) in 31.2% (n = 62), and MGN was the second common cause in 19.1% (n = 38), blood group B (37.1%) in FSGS, blood group O (46.7%) in systemic lupus erythematosus, MGN (63.2%), IgA nephropathy (50%), and MPGN (52.2%) was found most frequently in blood group A. Conclusions: We did not find a significant relationship between the blood group and NS in our study. [ABSTRACT FROM AUTHOR]
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- 2021
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18. The effect of RAAS inhibitors on acute hypoxemic respiratory failure and in-hospital mortality in the hypertensive Covid-19 patients.
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Akyüz, Abdurrahman, Işık, Ferhat, Aslan, Burhan, Çap, Murat, Kaya, İlyas, Atlı, Özgür, İnci, Ümit, Taştan, Ercan, Aktan, Adem, Bilge, Önder, Okşul, Metin, Aydın, Emre, Karahan, Zülküf, Altıntaş, Derya Deniz, Altındağ, Rojhat, Adıyaman, Mehmet Şahin, and Altıntaş, Bernas
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COVID-19 ,HOSPITAL mortality ,HYPERTENSION ,CORONARY artery disease ,ADRENERGIC beta blockers ,ANTIHYPERTENSIVE agents ,FIBRIN fragment D - Abstract
We have aimed to investigate the relationship between use of angiotensin-converting-enzyme inhibitor (ACEI) or angiotensin-receptor-blocker (ARB) drugs and acute hypoxemic respiratory failure (AHRF) and in-hospital mortality in hypertensive Covid-19 patients. Consecutive 1345 patients diagnosed with Covid-19 between April and October 2020 who met inclusion criteria were divided into two groups based on presence and absence of AHRF and mortality. The groups were compared regarding epidemiological, clinical, radiological, laboratory findings and treatments methods. The patient groups ACEI, ARB and other antihypertensive drugs (non-ACEI/ARB) were compared regarding same parameters. Median age was 68 (60–76) years in the patient group including 805 (59.9.1%) females. Of the patients, 475 (35.3%), 644 (47.9%) and 226 (16.8%) were using ACEIs, ARBs and non-ACEI/ARB, respectively. AHRF and in-hospital mortality developed in 1053 (78.3%) and 290 (21.6%) patients, respectively. Age, gender, coronary artery disease, diabetes mellitus (DM), neutrophil, lymphocyte, creatinine, D-dimer, C-reactive protein (CRP), ACEI, beta blocker and aspartate transaminase (AST) found statistically significant in the univariable logistic regression performed to identify independent predictors of mortality were included multivariable logistic regression model. Age (OR: 1.066, 95%CI: 1.049–1.083; p <.001), DM (OR: 1.682, 95%CI: 1.238–2.286; p =.001), neutrophil (OR: 1.041, 95%CI: 1.007–1.077; p =.019), creatinine (OR: 1.178, 95%CI: 1.048–1.325; p =.006), CRP (OR: 1.008, 95%CI: 1.006–1.010; p <.001), ACEI (OR: 0.718, 95%CI: 0.521–0.988; p =.042), AST (OR: 1.005, 95%CI: 1.001–1.010; p =.010) were found associated with in-hospital mortality. In our study, it was not detected clinically significant difference between three groups with regard to their relation with in-hospital mortality. [ABSTRACT FROM AUTHOR]
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- 2021
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19. Clinical Outcomes and Independent Risk Factors for 90-Day Mortality in Critically Ill Patients with Respiratory Failure Infected with SARS-CoV-2: A Multicenter Study in Turkish Intensive Care Units.
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Gündoğan, Kürşat, Akbudak, İsmail Hakkı, Hancı, Pervin, Halaçlı, Burçin, Temel, Şahin, Güllü, Zuhal, İnci, Kamil, Bilir, Yeliz, Bozkurt, Firdevs Tuğba, Yıldırım, Fatma, Şimşek, Meltem, Yüksel, Recep Civan, Eren, Esma, Altıntaş, Neriman Defne, Talan, Leyla, Elay, Gülseren, Güven, Göksel, Kara, İskender, Aydın, Emre, and Yılmaz, Seda
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MORTALITY risk factors ,INTENSIVE care units ,RESEARCH ,LENGTH of stay in hospitals ,VASOCONSTRICTORS ,EVALUATION of medical care ,RESPIRATORY insufficiency ,SCIENTIFIC observation ,CONFIDENCE intervals ,CRITICALLY ill ,OPERATIVE surgery ,PATIENTS ,MEDICAL cooperation ,RETROSPECTIVE studies ,HOSPITAL mortality ,ARTIFICIAL respiration ,TREATMENT effectiveness ,DESCRIPTIVE statistics ,LACTATES ,ODDS ratio - Abstract
Background: There are limited data on the long-term outcomes of COVID-19 from different parts of the world. Aims: To determine risk factors of 90-day mortality in critically ill patients in Turkish intensive care units (ICUs), with respiratory failure. Study design: Retrospective, observational cohort. Methods: Patients with laboratory-confirmed COVID-19 and who had been followed up in the ICUs with respiratory failure for more than 24 hours were included in the study. Their demographics, clinical characteristics, laboratory variables, treatment protocols, and survival data were recorded. Results: A total of 421 patients were included. The median age was 67 (IQR: 57-76) years, and 251 patients (59.6%) were men. The 90-day mortality rate was 55.1%. The factors independently associated with 90-day mortality were invasive mechanical ventilation (IMV) (HR 4.09 [95% CI: [2.20-7.63], P < .001), lactate level >2 mmol/L (2.78 [1.93-4.01], P < .001), age >60 years (2.45 [1.48-4.06)], P < .001), cardiac arrhythmia during ICU stay (2.01 [1.27-3.20], P = .003), vasopressor treatment (1.94 [1.32-2.84], P = .001), positive fluid balance of ≥600 mL/day (1.68 [1.21-2.34], P = .002), PaO
2 /FiO2 ratio of ≤150 mmHg (1.66 [1.18-2.32], P = .003), and ECOG score ≥ 1 (1.42 [1.00-2.02], P = .050). Conclusion: Long-term mortality was high in critically ill patients with COVID-19 hospitalized in intensive care units in Turkey. Invasive mechanical ventilation, lactate level, age, cardiac arrhythmia, vasopressor therapy, positive fluid balance, severe hypoxemia and ECOG score were the independent risk factors for 90-day mortality. [ABSTRACT FROM AUTHOR]- Published
- 2021
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20. Anaokulu çağındaki çocukların hikâye ve bilgilendirici kitaplardan bilgi edinimleri
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Aydın, Emre and Ilgaz, Hande
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False information ,Preschool children ,Expository books ,Narrative books ,Selective-learning - Abstract
Cataloged from PDF version of article. Thesis (M.S.): Bilkent University, Department of Psychology, İhsan Doğramacı Bilkent University, 2017. Includes bibliographical references (leaves 54-58). Expository and narrative books differ in terms of their structure, content, and language. This study investigated 3- and 5-year-old children’s learning of information from different genres, and whether children differ in their preference for the expository genre. Seventy six Turkish-speaking 3- and 5-year olds were presented with expository and narrative books that cover the same topic (i.e., caterpillars). These books contained 4 types of facts (i.e., Narrative-only, Expository-only, Conflicting and Supporting) that aim to investigate: (1) Amount of information children learned from the expository and the narrative book, (2) Children’s preference for the expository book when information between genres conflicted, (3) The effect of convergent information in both the expository and the narrative book on children’s learning. After hearing both the expository and the narrative book each child was asked questions related to information presented in the books. Analysis of children’s answers revealed that 5-year-olds learned more information from both the narrative and the expository book. When information conflicted between narrative and expository books, 3- and 5-year-olds differed in their preference for the expository book. Five-year-olds showed a preference for the expository book whereas 3-year-olds were at chance level indicating susceptibility to learn false information. Lastly, when information converged across the two genres all children regardless of age retained more information. Findings and their implications are discussed in light of the literature. by Emre Aydın. M.A.
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- 2017
21. Serum 25-Hydroxy Vitamin D, Vitamin B12, and Folic Acid.
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Aslan, Mehmet Gökhan, Fındık, Hüseyin, Okutucu, Murat, Aydın, Emre, Oruç, Yavuz, Arpa, Medeni, and Uzun, Feyzahan
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- 2021
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22. Evaluation of the effect of red cell distribution width on the development of acute renal failure in patients with sepsis.
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Kara, Ali Veysel, Tanrikulu, Sema, Aydın, Emre, Aydın, Fatma, Soylu, Hikmet, Yıldırım, Yaşar, Yılmaz, Zülfükar, Kadiroğlu, Ali Kemal, and Yılmaz, Mehmet Emin
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ERYTHROCYTES , *ACUTE kidney failure , *SEPSIS , *PATIENTS - Abstract
Objective: Acute kidney injury (AKI) is an important clinical entity that is known to increase mortality in patients with sepsis. Erythrocyte maturation and proliferation are inhibited by pro-inflammatory cytokines; these cytokines exert effects on red cell distribution width (RDW) well. Based on this knowledge; our aim in this study was to evaluate the impact of RDW on acute kidney injury in patients with sepsis. Methods: 120 patients diagnosed with sepsis and admitted to intesive care unit (ICU) and treated between 2009-2013 were retrospectively evaluated. Patients were divided into two groups as follows: group 1 (RDW≥16.8) and group 2 (RDW<16.8). Multiple logistic regression analysis was used to determine the association between RDW and AKI and mortality. Results: There was a statistically significant relationship between AKI and RDW (p<0.001, OR=11.52) but there were no statistically significant relationship between AKI and sex, age, serum lactate levels as well as SOFA score. Also, there were statistically significant relationship between mortality and RDW (p=0.044, OR=5), serum lactate levels (p=0.030) and SOFA score (p<0.001). RDW was found associated with both AKI and mortality. Conclusions: Results suggest that RDW is an important parameter for predicting development of AKI and mortality in ICU patients with sepsis. [ABSTRACT FROM AUTHOR]
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- 2017
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23. The effect of RAAS inhibitors on acute hypoxemic respiratory failure and in-hospital mortality in the hypertensive Covid-19 patients
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Özgür Atlı, Ümit İnci, Abdurrahman Akyüz, Adem Aktan, Metin Okşul, Emre Aydin, Ercan Taştan, İlyas Kaya, Derya Deniz Altıntaş, Bernas Altıntaş, Murat Çap, Rojhat Altındağ, Önder Bilge, Burhan Aslan, Zülküf Karahan, Ferhat Işık, Mehmet Şahin Adıyaman, Dicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıklar Ana Bilim Dalı, and Aydın, Emre
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Male ,Physiology ,Angiotensin-Converting Enzyme Inhibitors ,030204 cardiovascular system & hematology ,Logistic regression ,Covid-19 infection ,Coronary artery disease ,Renin-Angiotensin System ,chemistry.chemical_compound ,0302 clinical medicine ,Epidemiology ,030212 general & internal medicine ,Hospital Mortality ,Acute hypoxemic respiratory failure ,biology ,General Medicine ,Middle Aged ,ARB ,Hypertension ,Female ,Respiratory Insufficiency ,Research Article ,ACEI ,medicine.medical_specialty ,hypertension ,medicine.drug_class ,Aspartate transaminase ,İn-hospital mortality ,03 medical and health sciences ,Angiotensin Receptor Antagonists ,Internal medicine ,Diabetes mellitus ,Internal Medicine ,medicine ,Humans ,cardiovascular diseases ,Beta blocker ,Aged ,Retrospective Studies ,Creatinine ,business.industry ,acute hypoxemic respiratory failure ,COVID-19 ,Retrospective cohort study ,medicine.disease ,COVID-19 Drug Treatment ,chemistry ,biology.protein ,business ,in-hospital mortality - Abstract
WOS:000648071100001 PMID: 33955313 Introduction We have aimed to investigate the relationship between use of angiotensin-converting-enzyme inhibitor (ACEI) or angiotensin-receptor-blocker (ARB) drugs and acute hypoxemic respiratory failure (AHRF) and in-hospital mortality in hypertensive Covid-19 patients. Material and method Consecutive 1345 patients diagnosed with Covid-19 between April and October 2020 who met inclusion criteria were divided into two groups based on presence and absence of AHRF and mortality. The groups were compared regarding epidemiological, clinical, radiological, laboratory findings and treatments methods. The patient groups ACEI, ARB and other antihypertensive drugs (non-ACEI/ARB) were compared regarding same parameters. Results Median age was 68 (60-76) years in the patient group including 805 (59.9.1%) females. Of the patients, 475 (35.3%), 644 (47.9%) and 226 (16.8%) were using ACEIs, ARBs and non-ACEI/ARB, respectively. AHRF and in-hospital mortality developed in 1053 (78.3%) and 290 (21.6%) patients, respectively. Age, gender, coronary artery disease, diabetes mellitus (DM), neutrophil, lymphocyte, creatinine, D-dimer, C-reactive protein (CRP), ACEI, beta blocker and aspartate transaminase (AST) found statistically significant in the univariable logistic regression performed to identify independent predictors of mortality were included multivariable logistic regression model. Age (OR: 1.066, 95%CI: 1.049-1.083; p < .001), DM (OR: 1.682, 95%CI: 1.238-2.286; p = .001), neutrophil (OR: 1.041, 95%CI: 1.007-1.077; p = .019), creatinine (OR: 1.178, 95%CI: 1.048-1.325; p = .006), CRP (OR: 1.008, 95%CI: 1.006-1.010; p < .001), ACEI (OR: 0.718, 95%CI: 0.521-0.988; p = .042), AST (OR: 1.005, 95%CI: 1.001-1.010; p = .010) were found associated with in-hospital mortality. Conclusion In our study, it was not detected clinically significant difference between three groups with regard to their relation with in-hospital mortality.
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- 2021
24. Comparison of the treatment efficacy of continuous renal replacement therapy and intermittent hemodialysis in patients with acute kidney injury admitted to the intensive care unit
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Fatma, Yılmaz Aydın, Emre, Aydın, Ali Kemal, Kadiroglu, Dicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıklar Ana Bilim Dalı, Aydın, Fatma Yılmaz, Aydın, Emre, and Kadiroğlu, Ali Kemal
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General Engineering ,Renal replacement therapy (rrt) ,Intensive care unit ,Mortality ,Continuous renal replacement therapy (crrt) ,Intermittent hemodialysis ,Acute kidney injury - Abstract
WOS:000758928100011 PMID: 35242474 Abstract Introduction and aim Acute kidney injury (AKI) is part of the multiple organ dysfunction syndrome in critically ill patients and is a common condition in intensive care units (ICUs). Renal replacement therapy (RRT) is the cornerstone of treatment for AKI in critically ill patients. This patient population has a high mortality rate despite RRT. There are two methods of RRT for patients in ICUs: intermittent hemodialysis (IHD) and continuous renal replacement therapy (CRRT). Both CRRT and IHD similarly provide adequate metabolic control. We aimed to compare these two RRT modalities in terms of ICU stay, mortality, and laboratory recovery in these patients with high mortality. Materials and methods A total of 120 patients with AKI who needed RRT in the ICU were included in the study (CRRT, n:40; IHD, n:80). Acute Physiology and Chronic Health Evaluation (APACHE) II, Sepsis-related Organ Failure Assessment (SOFA), and Simplified Acute Physiology Score (SAPS)-II scores at the time of admission to the ICU were calculated. Mean arterial pressure, urea, creatinine, sodium, potassium, calcium, pH, lactate, and bicarbonate levels were measured before and after dialysis. Patients were classified as living and deceased. Factors affecting the length of stay in the intensive care unit and 30-day mortality were evaluated. The variability in laboratory parameters between groups before and after dialysis was examined. The groups were compared with these parameters. Results Sixty-one point seven percent (61.7%, n:74) of the patients were female. The mean age was 62.90 +/- 13.64 years. At the time of admission to the ICU, the patients' SAPS II score was 45.05 +/- 12.76, APACHE II score was 22.05 +/- 6.32, and SOFA score was 8.26 +/- 2.48. 66.7% (n:80) of the patients included in the study died, and the length of stay of these patients in the ICU was 12.85 +/- 10.23 days. When the groups were compared, SAPS II, APACHE II scores, and SOFA scores were significantly higher in the CRRT group than in the IHD group (p:0.038, p:0.015, p:0.027, respectively). Although the length of stay in the ICU was shorter in the CRRT group, it was not statistically significant (p:0.075). There was no statistically significant difference between the groups in terms of mortality (p: 0.891). SAPS-II, APACHE II, and SOFA score affected 30-day mortality while age, gender, and RRT modalities were not associated with mortality. The improvement in laboratory parameters between the pre and post-RRT groups was statistically more significant in the IHD group (p
- Published
- 2022
25. Evaluation of hospital acquired infections in the tertiary intensive care unit: a three-year analysis
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Fatma YILMAZ AYDIN, Emre AYDIN, Dicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıklar Ana Bilim Dalı, Aydın, Fatma Yılmaz, and Aydın, Emre
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Cultural Studies ,Urinary tract ,Linguistics and Language ,History ,Intensive care units ,Intensive Care Unit,Hospital Infections,Hospital-Acquired Infection Rate,Infectious Agents,Central Venous Catheter ,Infection control ,Language and Linguistics ,Hospital infections ,Health Care Sciences and Services ,Anthropology ,Sağlık Bilimleri ve Hizmetleri ,Catheter related infections ,Central venous catheter ,Gram negative bacteria - Abstract
Introduction: Hospital-acquired infections (HAI) occurring in intensive care units (ICUs) are an important risk factor for mortality and morbidity. In some patient groups followed in ICUs, the risk of developing nosocomial infections increases even more. Especially, patients with end-stage renal disease (ESRD) carry a serious risk for HAI when they are hospitalized in ICUs. Our aim is to determine the rate and incidence of hospital infection, the distribution of infections and the most common microorganisms in our ICU, to initiate appropriate empirical treatment and to prevent the development of antibiotic resistance. Material and Method: A total 158 patients with a diagnosis of hospital-acquired infection hospitalized between January 2017 and December 2019 at general internal medicine intensive care unit, were included in this study. The clinical findings, culture results and laboratory data of the patients were recorded. According to years, the HAI rate, density and infection agents in the ICU were determined. Results: 158 episodes of nosocomial infections were detected in 128 of 556 patients who were hospitalized within three years. The hospitalization day was 9048, and the three-year ICU HAI rate was calculated as 29.19%. HAI density was 17.45 in 1000 patient days. Bloodstream infection was the most common (30.38%), followed by ventilator-associated pneumonia (28.48%) and catheter-related urinary tract infection (24.68%). Gram-negative microorganisms were the most common infectious agents. Among the Gram-negative bacteria, the most frequently isolated bacteria were A. baumannii, K. pneumoniae and P. aeruginosa. Among Gram-positive bacteria, Enterococcus spp. was most frequently isolated Conclusion: The risk of HAI is high in patients hospitalized in ICUs. In order to control nosocomial infections, HAI incidences and rates should be evaluated, infectious agents, and prospective effective infection control strategies should be developed by taking necessary precautions according to surveillance results. These measures will significantly reduce the incidence of HAI.
- Published
- 2021
26. Evaluation of factors affecting morbidity, mortality, and graft survival in kidney transplant patients
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Emre Aydin, Muhammed Emre Sevim, Fatma Yilmaz Aydin, Dicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıklar Ana Bilim Dalı, Sevim, Muhammed Emre, Aydın, Fatma Yılmaz, and Aydın, Emre
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medicine.medical_specialty ,Medicine (General) ,General Mathematics ,graft survival ,kidney transplantation ,Böbrek nakli ,Kidney transplant ,acute rejection ,Kidney transplantation ,R5-920 ,Health Care Sciences and Services ,medicine ,Morbidity mortality ,Sağlık Bilimleri ve Hizmetleri ,Akut rejeksiyon ,business.industry ,Kidney Transplantation,Acute Rejection,Graft Survival ,Graft survival ,Greft sağkalımı ,medicine.disease ,Surgery ,surgical procedures, operative ,Medicine ,Acute rejection ,business - Abstract
Objective: The aim of this study is to examine and evaluate the clinical findings and affecting factors related to graft and patient survival in kidney transplant patients at Dicle University Hospital. Method: 72 patients who underwent kidney transplantation at Dicle University Medical Faculty Hospital between January 2012 and September 2019 were included in the study. Demographic characteristics of patients, transplantation types, clinical and laboratory findings, pre-transplant dialysis types, renal failure etiologies, post-transplant complications, average patient and graft survival times and patient characteristics at the time of diagnosis, laboratory values, and treatment modalities were investigated. Results: In this study, the data collected from 72 patients who had kidney transplantation and 68 donors was analysed. The mean age of the patients was 32,7±13,8 years. 31 of patients were female, 41 were male. 56 of the transplants were performed living donors and 12 from cadavers. 9 patients died. The mean of patient survival was 94±3,4 months. Graft loss occured in 15 patients. The mean of graft survival was 86±4,3 months. Acute rejection occured in 10 patients. Chronic allograft nephropathy occured in 19 patients. Chronic allograft nephropathy was found more frequently in patients with acute rejection (p=0.017). In addition, graft loss was more common in patients with chronic allograft nephropathy (p=0.002). The dialysis duration was less than 12 months, and the BMI of the recipient was below 30 had a positive effect on patient survival. Conclusion: Recipient obesity and long-term dialysis programs reduce patient survival. In addition, prevention of rejection has a positive effect on patient and graft survival. Amaç: Bu çalışmanın amacı Dicle Üniversitesi Hastanesi’nde böbrek nakli yapılan hastalarda greft ve hasta sağkalımına ilişkin klinik bulguları ve etki eden faktörleri incelemek ve değerlendirmektir. Yöntemler: Çalışmaya Ocak 2012- Eylül 2019 tarihleri arasında Dicle Üniversitesi Tıp Fakültesi Hastanesi’nde böbrek nakli yapılan 72 hasta dahil edildi. Çalışmaya dahil edilen hastaların demografik özellikleri, nakil tipleri, klinik ve laboratuvar bulguları, nakil öncesi diyaliz tipleri, böbrek yetmezliği etyolojileri, nakil sonrası gelişen komplikasyonlar, ortalama hasta ve greft sağkalım süreleri ve bu süreleri etkileyen tanı anındaki hasta özellikleri, laboratuvar değerleri, tedavi modaliteleri araştırıldı. Bulgular: Çalışmamızda böbrek nakli yapılan 72 hastanın ve 68 vericinin verileri analiz edildi. Hastaların ortalama yaşı 32,7±13,8 yıldı. 31 kadın, 41 erkek hasta vardı. Nakillerin 56’sı canlıdan, 12’si kadavradan yapılmıştı. Ortalama hasta sağkalımı 94±3,4 aydı. 15 hastada greft kaybı gelişmişti. 9 hasta eksitus olmuştu. Ortalama greft sağkalımı 86±4,3 aydı. 10 hastada akut rejeksiyon gelişmişti. 19 hastada kronik allograft nefropatisi gelişmişti. Kronik allograft nefropatisi, akut rejeksiyon gelişen hastalarda (p=0,017) daha sık saptandı. Ayrıca kronik allograft nefropatisi gelişen hastalarda greft kaybı daha sık olmaktaydı (p=0,002). Alıcının diyaliz süresinin ≤12 ay ve BKİ≤30 olması hasta sağkalımını olumlu etkilemişti. Sonuç: Alıcı obezitesi ve uzun süreli diyaliz programları hasta sağkalımını azaltmaktadır. Ayrıca rejeksiyonun önlenmesinin, hasta ve greft sağkalımına olumlu etkisi olmaktadır.
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- 2021
27. DETERMINING OF THE PREVALENCE OF NOSOCOMIAL INFECTIONS AND CAUSATIVE GRAM NEGATIVE BACILLI IN THE INTENSIVE CARE UNIT.
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Yılmaz, Süreyya, Yıldırım, Yaşar, Yılmaz, Zülfükar, Aydın, Emre, Aydın, Fatma Yılmaz, Barutcu, Sezgin, Kara, Ali Veysel, Kadiroğlu, Ali Kemal, and Yılmaz, Mehmet Emin
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Purpose: Nosocomial infections develop after 48-72 hours of hospitalization. Gram negative bacilli are generally the causative agent. 25% of all nosocomial infections develop in the intensive care units. Therefore, patients in the intensive care units are at high risk. This study aimed to determine the prevalence of nosocomial infections and causative gram negative bacilli in the Intensive Care Unit (ICU). Materials and Methods: 269 patients who were hospitalized in internal medicine intensive care unit (IMICU) of Dicle University Faculty of Medicine between june 2010- December 2010 were included in this study. Culture samples were taken from all of the patients who develops fever ( ≥38.5 C) after the hospitalization to the IMICU. Culture of blood, urine, sputum, central venous catheters, open wounds and deep tracheal aspirate were taken. Source and the prevalence of infection and distribution of the isolated causative pathogens were determined in the patients with gram negative bacilli reproduction. Results: 158 of the patients were male ( 58.7%) and 111 of the patients were female ( 41.3%). The mean ages of men and female were 58.81±16.91 and 56.44±19.16 years, respectively (p= 0.286). culture samples were taken from blood (16%), urine ( 8.6%), central venous catheter tips ( 6.3%), deep tracheal aspirates (10%), sputum (2.2%) and wound stabs (2.2%). Nosocomial infections were detected in 109 patients ( 40.5%). Pneumonia, urinary tract infections and gastrointestinal system infections were the most frequent infections respectively. Microorganisms were isolated from one sample in 97 patients, while 12 patients had more than focus. The most commonly isolated organisms were E.Coli (13.8%) and Pseudomonas Aeruginosa (7.4%), followed by Acinetobacter Baumannii (6.3%) and Stenotrophomonas Maltophilia (3.3%). Conclusion: Nosocomial infections in intensive care units have proved to be a serious problem. Surveillance studies should be performed for the isolated causative pathogens and measures should be taken to prevent the development of the ICU infections. [ABSTRACT FROM AUTHOR]
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- 2014
28. The relationship between acute kidney injury and inflammation-based parameters and mortality in oncologic intensive care patients
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Emre Aydin, Ali Kemal Kadiroglu, Mehmet Emin Yilmaz, Ali Veysel Kara, Fatma Yilmaz Aydin, Zülfükar Yilmaz, Yasar Yildirim, Mehmet Kucukoner, Abdurrahman Isikdogan, Dicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıklar Ana Bilim Dalı, Aydın, Emre E., Kadiroǧlu, Ali Kemal, Yilmaz Aydin, Fatma, and Kara, Ali Veysel
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medicine.medical_specialty ,business.industry ,Acute kidney injury ,Inflammation ,Critical Care and Intensive Care Medicine ,medicine.disease ,Intensive care ,medicine ,Intensive care unit ,medicine.symptom ,Mortality ,Intensive care medicine ,business ,Cancer - Abstract
WOS:000614471900004 Background and Aims: Cancer patients are admitted to intensive care units (ICU) due to primary diseases, treatment-related conditions or comorbid diseases. Acute kidney injury (AKI) and infections appear to be factors affecting mortality and morbidity in ICU follow-up. Therefore, in our study, we investigated the effect of AKI and inflammation-based parameters on mortality in cancer patients admitted to the ICU. Materials and Methods: In this study, 386 patients diagnosed with malignancy hospitalized between 2010 and 2014 in Dicle University Medical Faculty Internal Medicine ICU were included. The study was designed retrospectively. The demographic characteristics and clinical information of the patients were obtained from the files. Subsequently, patients were classified as non-survivors (group 1) and survivors (group 2). Both groups were compared in terms of the presence and stage of AKI by KDIGO definition, neutrophil / lymphocyte ratio (NLR) and platelet / lymphocyte ratio (PLR). Results: Creatinine, CRP, neutrophil counts were found to be significantly higher and albumin, hemoglobin, platelet and lymphocyte counts were found to be lower in group 1 (n=276) compared to group 2 (n=110). Length of ICU was longer in group 2 patients. There was a positive correlation between mortality and KDIGO stages and NLR. Mortality rate was increased 1.9 fold in KDIGO stage 1, 2.3 fold in stage 2, 2.4 fold in stage 3 and 1.5 fold if NLR>5. There was no statistically significant relationship between PLR and mortality. Conclusion: The presence of AKI and elevated inflammation-based parameters were associated with mortality in oncologic patients admitted to the ICU.
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- 2020
29. Evaluation of the effect of intraperitoneal etanercept administration on oxidative stress and inflammation indicators in the kidney and blood of experimental sepsis-induced rats
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İbrahim Kaplan, Mehmet Veysi Bahadir, Muzaffer Aydın Ketani, Mehmet Emin Yilmaz, Fatma Yilmaz Aydin, Zülfükar Yilmaz, Ali Kemal Kadiroglu, Berfin Kadiroğlu, Emre Aydin, Yasar Yildirim, Dicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıklar Ana Bilim Dalı, Aydın, Emre E., Yıldırım, Yaşar, Aydın, Fatma Yılmaz, Bahadır, Mehmet Veysi, Kaplan, İbrahim, Kadiroğlu, Berfin, Ketani, Muzaffer Aydın, Yılmaz, Zülfükar, Kadiroǧlu, Ali Kemal, and Yılmaz, Mehmet Emin
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0301 basic medicine ,Microbiology (medical) ,medicine.medical_specialty ,RC955-962 ,030231 tropical medicine ,030106 microbiology ,Inflammation ,Kidney ,medicine.disease_cause ,Gastroenterology ,Etanercept ,Rats, Sprague-Dawley ,Sepsis ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Arctic medicine. Tropical medicine ,Internal medicine ,Major Article ,medicine ,Animals ,biology ,Tumor Necrosis Factor-alpha ,business.industry ,Anti-Inflammatory Agents, Non-Steroidal ,C-reactive protein ,Triggering receptor expressed on myeloid cells ,Malondialdehyde ,medicine.disease ,Rats ,Disease Models, Animal ,Oxidative Stress ,Infectious Diseases ,medicine.anatomical_structure ,chemistry ,Oxidative stress ,biology.protein ,Parasitology ,Tumor necrosis factor alpha ,medicine.symptom ,business ,Injections, Intraperitoneal ,medicine.drug ,TNF-alpha - Abstract
INTRODUCTION: Sepsis is an important cause of mortality and morbidity, and inflammatory response and oxidative stress play major roles underlying its pathophysiology. Here, we evaluated the effect of intraperitoneal etanercept administration on oxidative stress and inflammation indicators in the kidney and blood of experimental sepsis-induced rats. METHODS: Twenty-eight adult Sprague Dawley rats were classified into Control (Group 1), Sepsis (Group 2), Sepsis+Cefazolin (Group 3), and Sepsis+Cefazolin+Etanercept (Group 4) groups. Kidney tissue and serum samples were obtained for biochemical and histopathological investigations and examined for the C reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), triggering receptor expressed on myeloid cells (TREM), and malondialdehyde (MDA) levels. RESULTS: The levels of TNF-α, TREM, and MDA in serum and kidney samples were significantly higher in rats from sepsis group than in rats from control group (p < 0.05). Group 3 showed a significant reduction in serum levels of TNF-α, CRP, and TREM as compared with Group 2 (p < 0.05). Serum TNF-α, CRP, TREM, and MDA levels and kidney TNF-α and TREM levels were significantly lower in Group 4 than in Group 2 (p < 0.05). Serum TNF-α and TREM levels in Group 4 were significantly lower than those in Group 3, and histopathological scores were significantly lower in Group 3 and Group 4 than in Group 2 (p < 0.05). Histopathological scores of Group 4 were significantly lower than those of Group 3 (p < 0.05). CONCLUSIONS: Etanercept, a TNF-α inhibitor, may ameliorate sepsis-induced oxidative stress, inflammation, and histopathological damage.
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- 2020
30. Relationship between epicardial adipose tissue and body composition as determined by multi-frequency bioelectrical impedance analysis in patients with stage 5 chronic kidney disease
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Aziz Karabulut, Fatma Yilmaz Aydin, Lezgin Dursun, Mehmet Emin Yilmaz, Zülfükar Yilmaz, Enver Yuksel, Ali Kemal Kadiroglu, Yasar Yildirim, Emre Aydin, Hasan İnce, Dicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıklar Ana Bilim Dalı, Yılmaz, Zülfükar, Aydın, Emre E., Yıldırım, Yaşar, Aydın, Fatma Yılmaz, Karabulut, Aziz, Dursun, Lezgin, Kadiroǧlu, Ali Kemal, and Yılmaz, Mehmet Emin
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Male ,medicine.medical_specialty ,medicine.medical_treatment ,Adipose tissue ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Clinical Research ,Internal medicine ,Electric Impedance ,Medicine ,Humans ,Renal Insufficiency ,Risk factor ,Renal Insufficiency, Chronic ,Chronic ,Dialysis ,business.industry ,Case-control study ,General Medicine ,Middle Aged ,medicine.disease ,Blood pressure ,Adipose Tissue ,Echocardiography ,030220 oncology & carcinogenesis ,Case-Control Studies ,Cardiology ,Linear Models ,Body Composition ,Kidney Failure, Chronic ,Female ,business ,Body mass index ,Bioelectrical impedance analysis ,Pericardium ,Kidney disease - Abstract
WOS:000513527600001 PMID: 32029697 Background: The main cause of mortality among chronic kidney disease (CKD) patients is cardiovascular disease (CVD). Epicardial adipose tissue (EAT) is considered to be novel cardiovascular risk factor. We assessed EAT in non-dialyzed stage 5 CKD patients and explored the association of EAT with body composition as determined by multi-frequency BIA. Material/Methods: The present included 70 stage 5 CKD patients who had not undergone dialysis and 40 healthy control subjects. EAT thickness was assessed by echocardiography. Hydration status and body composition were evaluated by multi-frequency bioelectrical impedance analysis. Results: Stage 5 CKD patients had significantly higher EAT thickness than healthy subjects (6.56±1.18 vs. 4.05±1.45, p
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- 2020
31. Management of side branch stenosis with pre-dilatation in coronary bifurcation disease.
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Çörekçioğlu B, Aydın E, Aydın M, Uysal H, Güner A, and Uzun F
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- Humans, Male, Middle Aged, Angioplasty, Balloon, Coronary, Coronary Angiography, Coronary Artery Disease therapy, Coronary Stenosis surgery, Coronary Stenosis therapy, Coronary Stenosis diagnostic imaging
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- 2024
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32. Retrobulbar Blood Flow Parameters in Patients With Anisometropic Amblyopia.
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Aydın E, Özgür E, İnsan A, and Gürün E
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Introduction We aim to compare retrobulbar blood flow parameters between the amblyopic eye and the fellow eye in patients with anisometropic amblyopia. Methods Peak systolic velocity (PSV) and end-diastolic velocity (EDV) of the ophthalmic artery (OA), central retinal artery (CRA), and posterior ciliary artery (PCA) were measured by color Doppler imaging (CDI), and the resistivity index (RI) and pulsatility index (PI) were calculated in 62 patients aged 12-40 years with anisometropic amblyopia. Results The mean PSV values of OA, CRA, and PCA in amblyopic and fellow eyes were 30.38 ± 10.34, 8.45 ± 2.27, and 8.03 ± 2.77, and 33.73 ± 14.46, 8.35 ± 2.05, and 8.81 ± 2.77, respectively. The mean EDV values of OA, CRA, and PCA in amblyopic and fellow eyes were 6.86 ± 2.64, 1.47 ± 1.59, and 1.94 ± 2.03, and 8.57 ± 4.30, 1.80 ± 1.73, and 2.32 ± 1.20, respectively. The mean RI values of OA, CRA, and PCA in amblyopic and fellow eyes were 0.77 ± 0.10, 0.85 ± 0.14, and 0.78 ± 0.15, and 0.75 ± 0.07, 0.79 ± 0.20, and 0.74 ± 0.13, respectively. OA-PSV and OA-EDV values were significantly lower in the amblyopic eye than in the healthy eye (p < 0.05). OA-RI values were significantly higher (p < 0.05) in the amblyopic eye than in the healthy eye. Conclusions Considering the decrease in PSV and EDV and the increase in RI, which are the blood flow parameters of the amblyopic eye, our study may provide guidance to focus on increasing blood flow in the treatment of amblyopia., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2023, Aydın et al.)
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- 2023
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33. Comparison of the Treatment Efficacy of Continuous Renal Replacement Therapy and Intermittent Hemodialysis in Patients With Acute Kidney İnjury Admitted to the Intensive Care Unit.
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Yılmaz Aydın F, Aydın E, and Kadiroglu AK
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Introduction and aim Acute kidney injury (AKI) is part of the multiple organ dysfunction syndrome in critically ill patients and is a common condition in intensive care units (ICUs). Renal replacement therapy (RRT) is the cornerstone of treatment for AKI in critically ill patients. This patient population has a high mortality rate despite RRT. There are two methods of RRT for patients in ICUs: intermittent hemodialysis (IHD) and continuous renal replacement therapy (CRRT). Both CRRT and IHD similarly provide adequate metabolic control. We aimed to compare these two RRT modalities in terms of ICU stay, mortality, and laboratory recovery in these patients with high mortality. Materials and methods A total of 120 patients with AKI who needed RRT in the ICU were included in the study (CRRT, n:40; IHD, n:80). Acute Physiology and Chronic Health Evaluation (APACHE) II, Sepsis-related Organ Failure Assessment (SOFA), and Simplified Acute Physiology Score (SAPS)-II scores at the time of admission to the ICU were calculated. Mean arterial pressure, urea, creatinine, sodium, potassium, calcium, pH, lactate, and bicarbonate levels were measured before and after dialysis. Patients were classified as living and deceased. Factors affecting the length of stay in the intensive care unit and 30-day mortality were evaluated. The variability in laboratory parameters between groups before and after dialysis was examined. The groups were compared with these parameters. Results Sixty-one point seven percent (61.7%, n:74) of the patients were female. The mean age was 62.90±13.64 years. At the time of admission to the ICU, the patients' SAPS II score was 45.05±12.76, APACHE II score was 22.05±6.32, and SOFA score was 8.26±2.48. 66.7% (n:80) of the patients included in the study died, and the length of stay of these patients in the ICU was 12.85±10.23 days. When the groups were compared, SAPS II, APACHE II scores, and SOFA scores were significantly higher in the CRRT group than in the IHD group (p:0.038, p:0.015, p:0.027, respectively). Although the length of stay in the ICU was shorter in the CRRT group, it was not statistically significant (p:0.075). There was no statistically significant difference between the groups in terms of mortality (p: 0.891). SAPS-II, APACHE II, and SOFA score affected 30-day mortality while age, gender, and RRT modalities were not associated with mortality. The improvement in laboratory parameters between the pre and post-RRT groups was statistically more significant in the IHD group (p<0.001). It was determined that there was a statistically greater decrease in mean arterial pressure in the IHD group (p<0.001). Conclusions It was determined that there was no difference between the CRRT and IHD modalities applied in patients with AKI admitted to the ICU in terms of mortality and length of stay in the ICU. It was observed that both modalities improved on laboratory parameters, but the improvement was greater in the IHD group. However, it was determined that there was a statistically greater decrease in mean arterial pressure in the IHD group., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2022, Yılmaz Aydın et al.)
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- 2022
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34. The Role of Monocyte to High-Density Lipoprotein Cholesterol Ratio in Predicting the Severity of Proteinuria and Renal Dysfunction in Primary Nephrotic Syndrome.
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Yılmaz Aydın F, Eynel E, Oruç İ, Ince H, Yüksel E, and Aydın E
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Introduction: Monocyte to high-density lipoprotein (HDL) cholesterol ratio (MHR) has emerged as a novel marker of endothelial injury, inflammation, and oxidative stress. This study aimed to investigate the effect of MHR on primary nephrotic syndrome (NS) and its relationship with the severity of proteinuria., Methods: This study enrolled 161 patients newly diagnosed with primary NS and 100 healthy individuals. Demographic characteristics of the patients, primary NS diagnosis, basal laboratory parameters, the amount of 24-hour urinary protein excretion, and MHR were recorded. The groups were compared regarding these parameters., Results: MHR was significantly higher in patients with primary NS compared with the healthy group (12.89 ± 4.86 and 9.71 ± 2.30, respectively; p < 0.001). There was no difference between the groups in terms of age and sex. The amount of protein in the 24-hour urine in patients with a diagnosis of primary NS was 6.91 ± 3.73 g/day. The correlation analysis showed a positive correlation between MHR and the amount of proteinuria (r = 0.519, p < 0.001) and creatinine level (r = 0.167, p = 0.034). The multivariate regression analysis found that the severity of proteinuria was independently correlated to MHR (p < 0.001). According to the receiver operating characteristic curve analysis, the optimal cut-off level for MHR in NS was 10.08 (area under the curve of 0.704, sensitivity of 68%, and a specificity of 62%)., Conclusion: Our study is the first to compare the severity of proteinuria and renal functions with MHR in patients with primary NS. We believe that MHR can be used as a biomarker to determine inflammation, endothelial injury, and the level of oxidative stress, and may be useful to predict prognosis in patients with primary NS., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2021, Yılmaz Aydın et al.)
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- 2021
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35. Evaluation of the effect of intraperitoneal etanercept administration on oxidative stress and inflammation indicators in the kidney and blood of experimental sepsis-induced rats.
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Aydın E, Yıldırım Y, Aydın FY, Bahadır MV, Kaplan İ, Kadiroğlu B, Ketani MA, Yılmaz Z, Kadiroğlu AK, and Yılmaz ME
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- Animals, Anti-Inflammatory Agents, Non-Steroidal pharmacology, Disease Models, Animal, Etanercept pharmacology, Inflammation pathology, Injections, Intraperitoneal, Rats, Rats, Sprague-Dawley, Sepsis blood, Anti-Inflammatory Agents, Non-Steroidal administration & dosage, Etanercept administration & dosage, Inflammation prevention & control, Kidney drug effects, Oxidative Stress drug effects, Sepsis pathology, Tumor Necrosis Factor-alpha blood
- Abstract
Introduction: Sepsis is an important cause of mortality and morbidity, and inflammatory response and oxidative stress play major roles underlying its pathophysiology. Here, we evaluated the effect of intraperitoneal etanercept administration on oxidative stress and inflammation indicators in the kidney and blood of experimental sepsis-induced rats., Methods: Twenty-eight adult Sprague Dawley rats were classified into Control (Group 1), Sepsis (Group 2), Sepsis+Cefazolin (Group 3), and Sepsis+Cefazolin+Etanercept (Group 4) groups. Kidney tissue and serum samples were obtained for biochemical and histopathological investigations and examined for the C reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), triggering receptor expressed on myeloid cells (TREM), and malondialdehyde (MDA) levels., Results: The levels of TNF-α, TREM, and MDA in serum and kidney samples were significantly higher in rats from sepsis group than in rats from control group (p < 0.05). Group 3 showed a significant reduction in serum levels of TNF-α, CRP, and TREM as compared with Group 2 (p < 0.05). Serum TNF-α, CRP, TREM, and MDA levels and kidney TNF-α and TREM levels were significantly lower in Group 4 than in Group 2 (p < 0.05). Serum TNF-α and TREM levels in Group 4 were significantly lower than those in Group 3, and histopathological scores were significantly lower in Group 3 and Group 4 than in Group 2 (p < 0.05). Histopathological scores of Group 4 were significantly lower than those of Group 3 (p < 0.05)., Conclusions: Etanercept, a TNF-α inhibitor, may ameliorate sepsis-induced oxidative stress, inflammation, and histopathological damage.
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- 2020
- Full Text
- View/download PDF
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