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Glioma is the most common primary intracranial neoplasm in adults. Radiotherapy is a treatment approach in glioma patients, and Magnetic Resonance Imaging (MRI) is a beneficial diagnostic tool in treatment planning. Treatment response assessment in glioma patients is usually based on the Response Assessment in Neuro Oncology (RANO) criteria. The limitation of assessment based on RANO is two-dimensional (2D) manual measurements. Deep learning (DL) has great potential in neuro-oncology to improve the accuracy of response assessment. In the current research, firstly, the BraTS 2018 Challenge dataset included 210 HGG and 75 LGG were applied to train a designed U-Net network for automatic tumor and intra-tumoral segmentation, followed by training of the designed classifier with transfer learning for determining grading HGG and LGG. Then, designed networks were employed for the segmentation and classification of local MRI images of 49 glioma patients pre and post-radiotherapy. The results of tumor segmentation and its intra-tumoral regions were utilized to determine the volume of different regions and treatment response assessment. Treatment response assessment demonstrated that radiotherapy is effective on the whole tumor and enhancing region with p-value ≤ 0.05 with a 95% confidence level, while it did not affect necrosis and peri-tumoral edema regions. This work demonstrated the potential of using deep learning in MRI images to provide a beneficial tool in the automated treatment response assessment so that the patient can obtain the best treatment., (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

This study introduces TooT-PLM-ionCT, a comprehensive framework that consolidates three distinct systems, each meticulously tailored for one of the following tasks: distinguishing ion channels (ICs) from membrane proteins (MPs), segregating ion transporters (ITs) from MPs, and differentiating ICs from ITs. Drawing upon the strengths of six Protein Language Models (PLMs)-ProtBERT, ProtBERT-BFD, ESM-1b, ESM-2 (650M parameters), and ESM-2 (15B parameters), TooT-PLM-ionCT employs a combination of traditional classifiers and deep learning models for nuanced protein classification. Originally validated on an existing dataset by previous researchers, our systems demonstrated superior performance in identifying ITs from MPs and distinguishing ICs from ITs, with the IC-MP discrimination achieving state-of-the-art results. In light of recommendations for additional validation, we introduced a new dataset, significantly enhancing the robustness and generalization of our models across bioinformatics challenges. This new evaluation underscored the effectiveness of TooT-PLM-ionCT in adapting to novel data while maintaining high classification accuracy. Furthermore, this study explores critical factors affecting classification accuracy, such as dataset balancing, the impact of using frozen versus fine-tuned PLM representations, and the variance between half and full precision in floating-point computations. To facilitate broader application and accessibility, a web server (https://tootsuite.encs.concordia.ca/service/TooT-PLM-ionCT) has been developed, allowing users to evaluate unknown protein sequences through our specialized systems for IC-MP, IT-MP, and IC-IT classification tasks., (© 2024 The Authors. Proteins: Structure, Function, and Bioinformatics published by Wiley Periodicals LLC.)

Background: Breath-holding (BH) for cine balanced steady state free precession (bSSFP) imaging is challenging for patients with impaired BH capacity. Deep learning-based reconstruction (DLR) of undersampled k-space promises to shorten BHs while preserving image quality and accuracy of ventricular assessment., Purpose: To perform a systematic evaluation of DLR of cine bSSFP images from undersampled k-space over a range of acceleration factors., Study Type: Retrospective., Subjects: Fifteen pectus excavatum patients (mean age 16.8 ± 5.4 years, 20% female) with normal cardiac anatomy and function and 12-second BH capability., Field Strength/sequence: 1.5-T, cine bSSFP., Assessment: Retrospective DLR was conducted by applying compressed sensitivity encoding (C-SENSE) acceleration to systematically undersample fully sampled k-space cine bSSFP acquisition data over an acceleration/undersampling factor (R) considering a range of 2 to 8. Quality imperceptibility (QI) measures, including structural similarity index measure, were calculated using images reconstructed from fully sampled k-space as a reference. Image quality, including contrast and edge definition, was evaluated for diagnostic adequacy by three readers with varying levels of experience in cardiac MRI (>4 years, >18 years, and 1 year). Automated DL-based biventricular segmentation was performed commercially available software by cardiac radiologists with more than 4 years of experience., Statistical Tests: Tukey box plots, linear mixed effects model, analysis of variance (ANOVA), weighted kappa, Kruskal-Wallis test, and Wilcoxon signed-rank test were employed as appropriate. A P-value <0.05 was considered statistically significant., Results: There was a significant decrease in the QI values and edge definition scores as R increased. Diagnostically adequate image quality was observed up to R = 5. The effect of R on all biventricular volumetric indices was non-significant (P = 0.447)., Data Conclusion: The biventricular volumetric indices obtained from the reconstruction of fully sampled cine bSSFP acquisitions and DLR of the same k-space data undersampled by C-SENSE up to R = 5 may be comparable., Evidence Level: 3 TECHNICAL EFFICACY: Stage 1., (© 2023 The Authors. Journal of Magnetic Resonance Imaging published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.)

Magnetic resonance imaging (MRI) is a ubiquitous medical imaging technology with applications in disease diagnostics, intervention, and treatment planning. Accurate MRI segmentation is critical for diagnosing abnormalities, monitoring diseases, and deciding on a course of treatment. With the advent of advanced deep learning frameworks, fully automated and accurate MRI segmentation is advancing. Traditional supervised deep learning techniques have advanced tremendously, reaching clinical-level accuracy in the field of segmentation. However, these algorithms still require a large amount of annotated data, which is oftentimes unavailable or impractical. One way to circumvent this issue is to utilize algorithms that exploit a limited amount of labeled data. This paper aims to review such state-of-the-art algorithms that use a limited number of annotated samples. We explain the fundamental principles of self-supervised learning, generative models, few-shot learning, and semi-supervised learning and summarize their applications in cardiac, abdomen, and brain MRI segmentation. Throughout this review, we highlight algorithms that can be employed based on the quantity of annotated data available. We also present a comprehensive list of notable publicly available MRI segmentation datasets. To conclude, we discuss possible future directions of the field-including emerging algorithms, such as contrastive language-image pretraining, and potential combinations across the methods discussed-that can further increase the efficacy of image segmentation with limited labels., (© 2024 The Authors. NMR in Biomedicine published by John Wiley & Sons Ltd.)

Objective: This study aimed to evaluate the significance of background noise in machine learning models assessing the GRBAS scale for voice disorders., Methods: A dataset of 1406 voice samples was collected from retrospective data, and a 5-layer 1D convolutional neural network (CNN) model was constructed using TensorFlow. The dataset was divided into training, validation, and test data. Gaussian noise was added to test samples at various intensities to assess the model's noise resilience. The model's performance was evaluated using accuracy, F1 score, and quadratic weighted Cohen's kappa score., Results: The model's performance on the GRBAS scale generally declined with increasing noise intensities. For the G scale, accuracy dropped from 70.9% (original) to 8.5% (at the highest noise), F1 score from 69.2% to 1.3%, and Cohen's kappa from 0.679 to 0.0. Similar declines were observed for the remaining RBAS components., Conclusion: The model's performance was affected by background noise, with substantial decreases in evaluation metrics as noise levels intensified. Future research should explore noise-tolerant techniques, such as data augmentation, to improve the model's noise resilience in real-world settings., Level of Evidence: This study evaluates a machine learning model using a single dataset without comparative controls. Given its non-comparative design and specific focus, it aligns with Level 4 evidence (Case-series) under the 2011 OCEBM guidelines Laryngoscope, 134:3537-3541, 2024., (© 2024 The Authors. The Laryngoscope published by Wiley Periodicals LLC on behalf of The American Laryngological, Rhinological and Otological Society, Inc.)

Purpose: Irradiation of the brain regions from nasopharyngeal carcinoma (NPC) radiotherapy (RT) is frequently unavoidable, which may result in radiation-induced cognitive deficit. Using deep learning (DL), the study aims to develop prediction models in predicting compromised cognition in patients following NPC RT using remote assessments and determine their relation to the quality of life (QoL) and MRI changes., Methods: Seventy patients (20-76 aged) with MRI imaging (pre- and post-RT (6 months-1 year)) and complete cognitive assessments were recruited. Hippocampus, temporal lobes (TLs), and cerebellum were delineated and dosimetry parameters were extracted. Assessments were given post-RT via telephone (Telephone Interview Cognitive Status (TICS), Telephone Montreal Cognitive Assessment (T-MoCA), Telephone Mini Addenbrooke's Cognitive Examination (Tele-MACE), and QLQ-H&N 43). Regression and deep neural network (DNN) models were used to predict post-RT cognition using anatomical and treatment dose features., Results: Remote cognitive assessments were inter-correlated (r > 0.9). TLs showed significance in pre- and post-RT volume differences and cognitive deficits, that are correlated with RT-associated volume atrophy and dose distribution. Good classification accuracy based on DNN area under receiver operating curve (AUROC) for cognitive prediction (T-MoCA AUROC = 0.878, TICS AUROC = 0.89, Tele-MACE AUROC = 0.919)., Conclusion: DL-based prediction models assessed using remote assessments can assist in predicting cognitive deficit following NPC RT. Comparable results of remote assessments in assessing cognition suggest its possibility in replacing standard assessments., Implications for Cancer Survivors: Application of prediction models in individual patient enables tailored interventions to be provided in managing cognitive changes following NPC RT., (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

Precision in the diagnosis of diverse central nervous system (CNS) tumor types is crucial for optimal treatment. DNA methylation profiles, which capture the methylation status of thousands of individual CpG sites, are state-of-the-art data-driven means to enhance diagnostic accuracy but are also time consuming and not widely available. Here, to address these limitations, we developed Deep lEarning from histoPathoLOgy and methYlation (DEPLOY), a deep learning model that classifies CNS tumors to ten major categories from histopathology. DEPLOY integrates three distinct components: the first classifies CNS tumors directly from slide images ('direct model'), the second initially generates predictions for DNA methylation beta values, which are subsequently used for tumor classification ('indirect model'), and the third classifies tumor types directly from routinely available patient demographics. First, we find that DEPLOY accurately predicts beta values from histopathology images. Second, using a ten-class model trained on an internal dataset of 1,796 patients, we predict the tumor categories in three independent external test datasets including 2,156 patients, achieving an overall accuracy of 95% and balanced accuracy of 91% on samples that are predicted with high confidence. These results showcase the potential future use of DEPLOY to assist pathologists in diagnosing CNS tumors within a clinically relevant short time frame., (© 2024. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.)

Background: Hyperspectral imaging (HSI), combined with machine learning, can help to identify characteristic tissue signatures enabling automatic tissue recognition during surgery. This study aims to develop the first HSI-based automatic abdominal tissue recognition with human data in a prospective bi-center setting., Methods: Data were collected from patients undergoing elective open abdominal surgery at two international tertiary referral hospitals from September 2020 to June 2021. HS images were captured at various time points throughout the surgical procedure. Resulting RGB images were annotated with 13 distinct organ labels. Convolutional Neural Networks (CNNs) were employed for the analysis, with both external and internal validation settings utilized., Results: A total of 169 patients were included, 73 (43.2%) from Strasbourg and 96 (56.8%) from Verona. The internal validation within centers combined patients from both centers into a single cohort, randomly allocated to the training (127 patients, 75.1%, 585 images) and test sets (42 patients, 24.9%, 181 images). This validation setting showed the best performance. The highest true positive rate was achieved for the skin (100%) and the liver (97%). Misclassifications included tissues with a similar embryological origin (omentum and mesentery: 32%) or with overlaying boundaries (liver and hepatic ligament: 22%). The median DICE score for ten tissue classes exceeded 80%., Conclusion: To improve automatic surgical scene segmentation and to drive clinical translation, multicenter accurate HSI datasets are essential, but further work is needed to quantify the clinical value of HSI. HSI might be included in a new omics science, namely surgical optomics, which uses light to extract quantifiable tissue features during surgery., (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

Objectives: To evaluate the relationship of changes in the deep learning-based CT quantification of interstitial lung disease (ILD) with changes in forced vital capacity (FVC) and visual assessments of ILD progression, and to investigate their prognostic implications., Methods: This study included ILD patients with CT scans at intervals of over 2 years between January 2015 and June 2021. Deep learning-based texture analysis software was used to segment ILD findings on CT images (fibrosis: reticular opacity + honeycombing cysts; total ILD extent: ground-glass opacity + fibrosis). Patients were grouped according to the absolute decline of predicted FVC (< 5%, 5-10%, and ≥ 10%) and ILD progression assessed by thoracic radiologists, and their quantification results were compared among these groups. The associations between quantification results and survival were evaluated using multivariable Cox regression analysis., Results: In total, 468 patients (239 men; 64 ± 9.5 years) were included. Fibrosis and total ILD extents more increased in patients with larger FVC decline (p < .001 in both). Patients with ILD progression had higher fibrosis and total ILD extent increases than those without ILD progression (p < .001 in both). Increases in fibrosis and total ILD extent were significant prognostic factors when adjusted for absolute FVC declines of ≥ 5% (hazard ratio [HR] 1.844, p = .01 for fibrosis; HR 2.484, p < .001 for total ILD extent) and ≥ 10% (HR 2.918, p < .001 for fibrosis; HR 3.125, p < .001 for total ILD extent)., Conclusion: Changes in ILD CT quantification correlated with changes in FVC and visual assessment of ILD progression, and they were independent prognostic factors in ILD patients., Clinical Relevance Statement: Quantifying the CT features of interstitial lung disease using deep learning techniques could play a key role in defining and predicting the prognosis of progressive fibrosing interstitial lung disease., Key Points: • Radiologic findings on high-resolution CT are important in diagnosing progressive fibrosing interstitial lung disease. • Deep learning-based quantification results for fibrosis and total interstitial lung disease extents correlated with the decline in forced vital capacity and visual assessments of interstitial lung disease progression, and emerged as independent prognostic factors. • Deep learning-based interstitial lung disease CT quantification can play a key role in diagnosing and prognosticating progressive fibrosing interstitial lung disease., (© 2023. The Author(s), under exclusive licence to European Society of Radiology.)

Background: Quantification of metabolites concentrations in institutional unit (IU) is important for inter-subject and long-term comparisons in the applications of magnetic resonance spectroscopy (MRS). Recently, deep learning (DL) algorithms have found a variety of applications on the process of MRS data. A quantification strategy compatible to DL base MRS spectral processing method is, therefore, useful., Materials and Methods: This study aims to investigate whether metabolite concentrations quantified using a convolutional neural network (CNN) based method, coupled with a scaling procedure that normalizes spectral signals for CNN input and linear regression, can effectively reflect variations in metabolite concentrations in IU across different brain regions with varying signal-to-noise ratios (SNR) and linewidths (LW). An error index based on standard error (SE) is proposed to indicate the confidence levels associated with metabolite predictions. In vivo MRS spectra were acquired from three brain regions of 43 subjects using a 3T system., Results: The metabolite concentrations in IU of five major metabolites, quantified using CNN and LCModel, exhibit similar ranges with Pearson's correlation coefficients ranging from 0.24 to 0.78. The SE of the metabolites shows a positive correlation with Cramer-Rao lower bound (CRLB) (r=0.46) and  absolute CRLB (r=0.81), calculated by multiplying CRLBs with the quantified metabolite content., Conclusion: In conclusion, the CNN based method with the proposed scaling procedures can be employed to quantify in vivo MRS spectra and derive metabolites concentrations in IU. The SE can be used as error index, indicating predicted uncertainties for metabolites and sharing information similar to the absolute CRLB., (© 2023. The Author(s), under exclusive licence to European Society for Magnetic Resonance in Medicine and Biology (ESMRMB).)

The use of Artificial Intelligence (AI) to preserve and promote cultural heritage has experienced significant growth in recent years. Among the various areas of cultural heritage, numismatics have emerged as a particularly promising field where we can develop AI solutions. Numismatics refers to the study of coins, tokens, paper money, and medals, which play a critical role in understanding human history and culture. However, there are still limited resources available to help researchers and collectors in the identification of coins. This is due to the vast number of coins in circulation, which presents a significant challenge in developing smart tools for classification tasks. This paper aims to provide a contribution to this setting. In particular, we start by creating a new dataset called EURO-Coin, which consists of images showing the side of coins with reliefs and is designed to facilitate the training and testing of AI models for euro coin classification. Then, we propose two approaches that leverage Convolutional Neural Networks and self-attention layers to classify the country and value of the coins. In our experiments, we obtain an accuracy of 86.9% for country classification and an accuracy of 96.4% for value classification. Finally, we conduct an ablation study to evaluate the impact of the preprocessing activities and attention layers in our approaches. [ABSTRACT FROM AUTHOR]

• We propose a semi-automatic annotation pipeline to obtain high-quality annotations for scientific papers. • We use a transformer-based generative model to generate both high quality layouts of papers and their annotations. • We populate layout regions with synthetically generated content exploiting a layout-agnostic technique. [Display omitted] Document layout analysis is an important task to extract information from scientific literature. Deep-learning solutions for document layout analysis require large collections of training data that are not always available. We generate a large number of synthetic pages to subsequently train a neural network to perform document object detection. The proposed pipeline allows users to deal with less common layouts for which it is not easy to find large annotated datasets. High-quality annotations for a small collection of papers are obtained through a semi-automatic approach. Then, a generative model, based on LayoutTransformer, is used to generate plausible layouts that are subsequently populated with random information to perform data augmentation. We evaluate the proposed method considering scientific articles with two different types of layouts: double and single columns. For double-column papers, we improve detection by 1% starting from 385 manually annotated scientific articles. For single-column papers, we improve detection by 49% starting from 218 articles. [ABSTRACT FROM AUTHOR]

Since deep low‐frequency tremors are considered to be associated with large earthquakes that occur adjacently on the same subducting plate interface, it is important to investigate tremors that occurred before the establishment of modern seismograph networks such as the High Sensitivity Seismograph Network (Hi‐net). We propose a deep‐learning solution to detect evidence of tremors in scanned images of paper seismogram records from over 50 years ago. In this study, we fine‐tuned a convolutional neural network (CNN) based on the Residual Network, which was pre‐trained using images of synthetic waveforms from our previous study, using a data set comprised of images generated from real seismic data recorded digitally by Hi‐net to facilitate a supervised analysis. The fine‐tuned CNN was able to predict the presence or absence of tremors in the Hi‐net images with an accuracy of 98.64%. Gradient‐weighted Class Activation Mapping heatmaps created to visualize model predictions indicated that the CNN's ability to detect tremors is not degraded by the presence of teleseisms. Once validated using the Hi‐net images, the CNN was applied to paper seismograms recorded from 1966 to 1977 at the Kumano observatory in southwest Japan, operated by Earthquake Research Institute, The University of Tokyo. The CNN showed potential for detecting tremors in scanned images of paper seismogram records from the past, facilitating downstream tasks such as the creation of new tremor catalogs. However, further training using an augmented data set to control for variables such as inconsistent plotting pen thickness is required to develop a universally applicable model. Plain Language Summary: In 2002, deep low‐frequency tremors, which periodically occur with much smaller amplitudes and longer durations than common earthquakes, were discovered owing to the establishment of dense seismic arrays in Japan. These tremors are considered to be associated with megathrust earthquakes because they occur in deeper regions of plate boundaries compared with common earthquakes. Investigating tremors that occurred before the establishment of dense seismic arrays is important since megathrust earthquakes recur on intervals of 100–200 years, and digital records from modern seismic arrays cover only a fraction of that time. In this study, we developed a convolutional neural network based on the Residual Network (ResNet) that extracts tremors from images of waveforms recorded more than 50 years ago, when seismometers drew waveforms directly on drum‐rolled paper using a pen. The proposed ResNet, which was trained on seismogram images generated from synthetic waveforms and real data recorded digitally by modern seismic arrays, was applied to scanned images of paper seismograms recorded from 1966 to 1977 at an observatory in southwest Japan. A list of tremors was successfully obtained; however, further training using data that accounts for variables such as inconsistent plotting pen thickness is required to develop a universally applicable model. Key Points: Convolutional neural network model for detection of deep low‐frequency tremors from seismogram images is proposedThe model trained with seismogram images converted from real seismic data successfully detects tremorsThe detection performances of the trained model for the paper records at the Kumano observatory in southwest Japan are discussed [ABSTRACT FROM AUTHOR]

Background: Breast cancer is a major public health concern, and early diagnosis and classification are critical for effective treatment. Machine learning and deep learning techniques have shown great promise in the classification and diagnosis of breast cancer., Purpose: In this review, we examine studies that have used these techniques for breast cancer classification and diagnosis, focusing on five groups of medical images: mammography, ultrasound, MRI, histology, and thermography. We discuss the use of five popular machine learning techniques, including Nearest Neighbor, SVM, Naive Bayesian Network, DT, and ANN, as well as deep learning architectures and convolutional neural networks., Conclusion: Our review finds that machine learning and deep learning techniques have achieved high accuracy rates in breast cancer classification and diagnosis across various medical imaging modalities. Furthermore, these techniques have the potential to improve clinical decision-making and ultimately lead to better patient outcomes., (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Background: Recent advancements in Deep Learning (DL) methodologies have led to state-of-the-art performance in a wide range of applications especially in object recognition, classification, and segmentation of medical images. However, training modern DL models requires a large amount of computation and long training times due to the complex nature of network structures and the large number of training datasets involved. Moreover, it is an intensive, repetitive manual process to select the optimized configuration of hyperparameters for a given DL network., Purpose: In this study, we present a novel approach to accelerate the training time of DL models via the progressive feeding of training datasets based on similarity measures for medical image segmentation. We term this approach Progressive Deep Learning (PDL)., Methods: The two-stage PDL approach was tested on the auto-segmentation task for two imaging modalities: CT and MRI. The training datasets were ranked according to similarity measures between each sample based on Mean Square Error (MSE), Peak Signal-to-Noise Ratio (PSNR), Structural Similarity Index (SSIM), and the Universal Quality Image Index (UQI) values. At the start of the training process, a relatively coarse sampling of training datasets with higher ranks was used to optimize the hyperparameters of the DL network. Following this, the samples with higher ranks were used in step 1 to yield accelerated loss minimization in early training epochs and the total dataset was added in step 2 for the remainder of training., Results: Our results demonstrate that the PDL approach can reduce the training time by nearly half (∼49%) and can predict segmentations (CT U-net/DenseNet dice coefficient: 0.9506/0.9508, MR U-net/DenseNet dice coefficient: 0.9508/0.9510) without major statistical difference (Wilcoxon signed-rank test) compared to the conventional DL approach. The total training times with a fixed cutoff at 0.95 DSC for the CT dataset using DenseNet and U-Net architectures, respectively, were 17 h, 20 min and 4 h, 45 min in the conventional case compared to 8 h, 45 min and 2 h, 20 min with PDL. For the MRI dataset, the total training times using the same architectures were 2 h, 54 min and 52 min in the conventional case and 1 h, 14 min and 25 min with PDL., Conclusion: The proposed PDL training approach offers the ability to substantially reduce the training time for medical image segmentation while maintaining the performance achieved in the conventional case., (© 2023 American Association of Physicists in Medicine.)

As more people express their thoughts on products on various online shopping platforms, the feelings expressed in these opinions are becoming a significant source of information for marketers and buyers. These opinions have a big impact on consumers' decision to buy the best quality product. When there are too many features or a small number of records to analyze, the decision-making process gets difficult. A recent stream of study has used the conventional quantitative star score ratings and textual content reviews in this context. In this research, a decision-making framework is proposed that relies on feature-based opinions to analyze the textual content of reviews and classify buyer's opinions, thereby assisting consumers in making long-term purchases. The framework is proposed in this paper for product purchase decision making based on feature-based opinions and deep learning. Framework consists of four components: i) Pre-processing, ii) Feature extraction, iii) Feature-based opinion classification, and iv) Decision-making. Web scraping is used to obtain the dataset of Smartphone reviews, which is subsequently clean and pre-processed using tokenization and POS tagging. From the tagged dataset, noun labeled words are retrieved, and then the probable product's features are extracted. These feature-based sentences or reviews are processed using a word embedding to generate review vectors that identify contextual information. These word vectors are used to construct hidden vectors at the word and sentence levels using a hierarchical attention method. With respect to each feature, reviews are divided into five classes: extremely positive, positive, extremely negative, negative, and neutral. The proposed method may readily detect a customer's opinion on the quality of a product based on a certain attribute, which is beneficial in making a purchase choice. [ABSTRACT FROM AUTHOR]

This research aimed to compare two strategies for vocabulary learning (digital-game-based learning and paper-based learning). The research was conducted during the first semester of the academic year 2022/2023. A total of 40 EFL undergraduate students within the Applied English Program of a private university located in the middle part of Taiwan were selected and divided into two groups: digital-based (n = 20) and paper-based (n = 20). The instrument developed by the researcher was pre- and post-vocabulary tests for both groups. The pre-vocabulary test was implemented to identify the level of students' prior knowledge of vocabulary mastery. For the intervention, Kahoot! quiz exercises were conducted weekly for the digital-game-based group, while the paper-based group received the same quiz on paper every week. The post-vocabulary tests showed no significant difference between the students using digital-game-based quizzes and paper-based quizzes during the six-week intervention. [ABSTRACT FROM AUTHOR]

Machine learning has been leveraged for image analysis applications throughout a multitude of subspecialties. This position paper provides a perspective on the evolutionary trajectory of practical deep learning tools for genitourinary pathology through evaluating the most recent iterations of such algorithmic devices. Deep learning tools for genitourinary pathology demonstrate potential to enhance prognostic and predictive capacity for tumor assessment including grading, staging, and subtype identification, yet limitations in data availability, regulation, and standardization have stymied their implementation. [ABSTRACT FROM AUTHOR]

The last decade has seen increasing use of advanced imaging techniques in platelet research. However, there has been a lag in the development of image analysis methods, leaving much of the information trapped in images. Herein, we present a robust analytical pipeline for finding and following individual platelets over time in growing thrombi. Our pipeline covers four steps: detection, tracking, estimation of tracking accuracy, and quantification of platelet metrics. We detect platelets using a deep learning network for image segmentation, which we validated with proofreading by multiple experts. We then track platelets using a standard particle tracking algorithm and validate the tracks with custom image sampling - essential when following platelets within a dense thrombus. We show that our pipeline is more accurate than previously described methods. To demonstrate the utility of our analytical platform, we use it to show that in vivo thrombus formation is much faster than that ex vivo . Furthermore, platelets in vivo exhibit less passive movement in the direction of blood flow. Our tools are free and open source and written in the popular and user-friendly Python programming language. They empower researchers to accurately find and follow platelets in fluorescence microscopy experiments.

Purpose: To investigate whether parallel imaging-imposed geometric coil constraints can be relaxed when using a deep learning (DL)-based image reconstruction method as opposed to a traditional non-DL method., Theory and Methods: Traditional and DL-based MR image reconstruction approaches operate in fundamentally different ways: Traditional methods solve a system of equations derived from the image data whereas DL methods use data/target pairs to learn a generalizable reconstruction model. Two sets of head coil profiles were evaluated: (1) 8-channel and (2) 32-channel geometries. A DL model was compared to conjugate gradient SENSE (CG-SENSE) and L1-wavelet compressed sensing (CS) through quantitative metrics and visual assessment as coil overlap was increased., Results: Results were generally consistent between experiments. As coil overlap increased, there was a significant (p < 0.001) decrease in performance in most cases for all methods. The decrease was most pronounced for CG-SENSE, and the DL models significantly outperformed (p < 0.001) their non-DL counterparts in all scenarios. CS showed improved robustness to coil overlap and signal-to-noise ratio (SNR) versus CG-SENSE, but had quantitatively and visually poorer reconstructions characterized by blurriness as compared to DL. DL showed virtually no change in performance across SNR and very small changes across coil overlap., Conclusion: The DL image reconstruction method produced images that were robust to coil overlap and of higher quality than CG-SENSE and CS. This suggests that geometric coil design constraints can be relaxed when using DL reconstruction methods., (© 2024 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.)

To enable a quick and accurate access of targeted scientific and technological literature from massive stocks, here a deep content-based collaborative filtering method, namely DeepCCF, for personalized scientific and technological literature resources recommendation was proposed. By combining content-based filtering (CBF) and neural network-based collaborative filtering (NCF), the approach transforms the problem of scientific and technological literature recommendation into a binary classification task. Firstly, the word2vec is used to train the words embedding of the papers' titles and abstracts. Secondly, an academic literature topic model is built using term frequency–inverse document frequency (TF-IDF) and word embedding. Thirdly, the search and view history and published papers of researchers are utilized to construct the model that portrays the interests of researchers. Deep neural networks (DNNs) are then used to learn the nonlinear and complicated high-order interaction features between users and papers, and the top k recommendation list is generated by predicting the outputs of the model. The experimental results show that our proposed method can quickly and accurately capture the latent relations between the interests of researchers and the topics of paper, and be able to acquire the researchers' preferences effectively as well. The proposed method has tremendous implications in personalized academic paper recommendation, to propel technological progress. [ABSTRACT FROM AUTHOR]

In the production of paper cups in industrial factories, it is tried to print high quality cups with less waste loss with the help of sensors and heating resistances mounted on the paper cup machine. In this study, a system that detects faulty products based on image processing and removes it by controlling the machine with servo motors, asynchronous motors and programmable logic controller (PLC) is designed. For fault product detection, classification has been performed using real-time Haarcascade algorithm and You Only Look Once (YOLO) algorithm which is a deep learning methods, and real-time object detection has been carried out using the OpenCv library. With this study, an effective faulty product detection and removing hardware system was realized by adapting artificial intelligence algorithms to a machine used in industry. Based on the results, a whole system can be applied to systems that involve removing a faulty product from a band in any production, packaging etc. facility is proposed. A hardware consisting of servo motors, asynchronous motors and PLC was designed to separate faulty cups from the existing paper cup production machine in this study. Then, a data set composed of 1068 images was created with images taken from the camera for faulty and faultless paper cups. Using this dataset, the effect of different deep learning methods on performance in the real-time system has been examined and successful results have been obtained. The optimal outcome was achieved, yielding a real-time application accuracy rate of 90.8% through the utilization of the Yolov5x architecture. [ABSTRACT FROM AUTHOR]

Background: Multimedia creation and curation for assignments have the potential to engage students in deeper learning. Objective: This study explored whether the same homework assignments delivered in paper versus multimedia format resulted in different student experiences. Method: Introductory psychology students submitted either traditional papers or multimedia projects to address the same assignment prompt, a process that was repeated seven times throughout four courses and was either instructor-determined or student-selected. Students were surveyed about the assignment formats, and assignment grades were analyzed. Results: Overall, students found the multimedia assignments more engaging, more enjoyable, more interesting, and more difficult than paper assignments. When assignments were instructor-determined, students reported higher perceived learning for the multimedia assignments. Assignment grades were not significantly different between assignment formats. Conclusion and teaching implications: These results suggest that moving traditional paper assignments into a multimedia format is a no-cost way to improve the student experience. [ABSTRACT FROM AUTHOR]

Accurate shelf-life estimation of food products has the potential to improve the safety, reliability, and sustainability of food supply chains. Here, a scalable system for accurately indicating the freshness-related information of salmon for consumers was developed and characterized. The system comprises two parts, an optically changeable colorimetric sensor by dye incorporated with sol-gel functionalized paper sensor and a deep convolutional neural network (DCNN)-based freshness estimation system based on images. The paper sensor was produced based on paper and immersed, coated, or printed with (3-aminopropyl) triethoxysilane (APTMS) and tetraethyl orthosilicate (TEOS) sol-gel particles and indicators (e.g., pH indicator, ammonia gas indicator, oxidation indicator, and other volatile organic compounds indicators). After being augmented by machine learning, the limit of detection reaches as low as 17.1 ppm for ammonia detection and the accuracy achieved up to 99.2% for salmon freshness estimation, which satisfied the application in food supply chains. The system balanced the trade-off between detection sensitivity, stability, and cost with the ability for scalable batch production. [ABSTRACT FROM AUTHOR]

Purpose: Urolithiasis is a chronic condition that leads to repeated CT scans throughout the patient's life. The goal was to assess the diagnostic performance and image quality of submillisievert abdominopelvic computed tomography (CT) using deep learning-based image reconstruction (DLIR) in urolithiasis., Methods: 57 patients with suspected urolithiasis underwent both non-contrast low-dose (LD) and ULD abdominopelvic CT. Raw image data of ULD CT were reconstructed using hybrid iterative reconstruction (ASIR-V 70%) and high-strength-level DLIR (DLIR-H). The performance of ULD CT for the detection of urinary stones was assessed by two readers and compared with LD CT with ASIR-V 70% as a reference standard. Image quality was assessed subjectively and objectively., Results: 266 stones were detected in 38 patients. Mean effective dose was 0.59 mSv for ULD CT and 1.96 mSv for LD CT. For diagnostic performance, sensitivity and specificity were 89% and 94%, respectively, for ULDCT with DLIR-H. There was an almost perfect intra-observer concordance on ULD CT with DLIR-H versus LDCT with ASIR-V 70% (ICC = 0.90 and 0.90 for the two readers). Image noise was significantly lower and signal-to-noise ratio significantly higher with DLIR-H compared to ASIR-V 70%. Subjective image quality was also significantly better with ULDCT with DLIR-H., Conclusion: ULD CT with Deep Learning Image Reconstruction maintains a good diagnostic performance in urolithiasis, with better image quality than hybrid iterative reconstruction and a significant radiation dose reduction., (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

Objectives: Accurate risk stratification of patients with stage II and III colorectal cancer (CRC) prior to treatment selection enables limited health resources to be efficiently allocated to patients who are likely to benefit from adjuvant chemotherapy. We aimed to investigate the cost-effectiveness of a recently developed deep learning-based prognostic method, Histotyping, from the perspective of the Norwegian healthcare system., Methods: Two partitioned survival models were developed to assess the cost-effectiveness of Histotyping for two treatment cohorts: patients with CRC stage II and III. For each of the two cohorts, Histotyping was used for risk stratification to assign adjuvant chemotherapy and was compared with the standard of care (SOC) (adjuvant chemotherapy to all patients). Health outcomes measured in the model were quality-adjusted life years (QALYs) and life years (LYs) gained. Deterministic and probabilistic sensitivity analyses were performed to determine the impact of uncertainty. Scenario analyses were performed to assess the impact of the parameters with the greatest uncertainty., Results: Risk-stratifying patients with CRC stage II and III using Histotyping was dominant (less costly and more effective) compared to SOC. In patients with CRC stage II, the net monetary benefit of Histotyping was 270,934 Norwegian kroners (NOK) (year of valuation is 2021), and the net health benefit of Histotyping was 0.99. In stage III, the net monetary benefit of Histotyping was 195,419 NOK, and the net health benefit of Histotyping was 0.71., Conclusions:  Risk-stratifying patients with CRC using Histotyping prior to the administration of adjuvant chemotherapy is likely to be a cost-effective strategy in Norway., (© 2024. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)

Background: In radiotherapy, real-time tumor tracking can verify tumor position during beam delivery, guide the radiation beam to target the tumor, and reduce the chance of a geometric miss. Markerless kV x-ray image-based tumor tracking is challenging due to the low tumor visibility caused by tumor-obscuring structures. Developing a new method to enhance tumor visibility for real-time tumor tracking is essential., Purpose: To introduce a novel method for markerless kV image-based tracking of lung tumors via deep learning-based target decomposition., Methods: We utilized a conditional Generative Adversarial Network (cGAN), known as Pix2Pix, to build a patient-specific model and generate the synthetic decomposed target image (sDTI) to enhance tumor visibility on the real-time kV projection images acquired by the onboard kV imager equipped on modern linear accelerators. We used 4DCT simulation images to generate the digitally reconstructed radiograph (DRR) and DTI image pairs for model training. We augmented the training dataset by randomly shifting the 4DCT in the superior-inferior, anterior-posterior, and left-right directions during the DRR and DTI generation process. We performed real-time 2D tumor tracking via template matching between the DTI generated from the CT simulation and the sDTI generated from the real-time kV projection images. We validated the proposed method using nine patients' datasets with implanted beacons near the tumor., Results: The sDTI can effectively improve the image contrast around the lung tumors on the kV projection images for the nine patients. With the beacon motion as ground truth, the tracking errors were on average 0.8 ± 0.7 mm in the superior-inferior (SI) direction and 0.9 ± 0.8 mm in the in-plane left-right (IPLR) direction. The percentage of successful tracking, defined as a tracking error less than 2 mm in the SI direction, is 92.2% on the 4312 tested images. The patient-specific model took approximately 12 h to train. During testing, it took approximately 35 ms to generate one sDTI, and 13 ms to perform the tumor tracking using template matching., Conclusions: Our method offers the potential solution for nearly real-time markerless lung tumor tracking. It achieved a high level of accuracy and an impressive tracking rate. Further development of 3D lung tumor tracking is warranted., (© 2024 American Association of Physicists in Medicine.)

This review article focuses on the applications of deep learning with neural networks and multimodal neural networks in the orthopaedic domain. By providing practical examples of how artificial intelligence (AI) is being applied successfully in orthopaedic surgery, particularly in the realm of imaging data sets and the integration of clinical data, this study aims to provide orthopaedic surgeons with the necessary tools to not only evaluate existing literature but also to consider AI's potential in their own clinical or research pursuits. We first review standard deep neural networks which can analyze numerical clinical variables, then describe convolutional neural networks which can analyze image data, and then introduce multimodal AI models which analyze various types of different data. Then, we contrast these deep learning techniques with related but more limited techniques such as radiomics, describe how to interpret deep learning studies, and how to initiate such studies at your institution. Ultimately, by empowering orthopaedic surgeons with the knowledge and know-how of deep learning, this review aspires to facilitate the translation of research into clinical practice, thereby enhancing the efficacy and precision of real-world orthopaedic care for patients., (Copyright © 2024 by the American Academy of Orthopaedic Surgeons.)

Background: Recommendations for cosmetics are gaining popularity, but they are not being made with consideration of the analysis of cosmetic ingredients, which customers consider important when selecting cosmetics., Aims: This article aims to propose a method for estimating the efficacy of cosmetics based on their ingredients and introduces a system that recommends personalized products for consumers, combined with AI skin analysis., Methods: We constructed a deep neural network architecture to analyze sequentially arranged cosmetic ingredients in the product and incorporated skin analysis models to get the precise skin status of users from frontal face images. Our recommendation system makes decisions based on the results optimized for the individual., Results: Our cosmetic recommendation system has shown its effectiveness through reliable evaluation metrics, and numerous examples have demonstrated its ability to make reasonable recommendations for various skin problems., Conclusion: The result shows that deep learning methods can be used to predict the effects of products based on their cosmetic ingredients and are available for use in personalized cosmetic recommendations., (© 2024 The Authors. Journal of Cosmetic Dermatology published by Wiley Periodicals LLC.)

Background: Panoramic radiography (PR) is available to determine the contact relationship between maxillary molar teeth (MMT) and the maxillary sinus floor (MSF). However, as PRs do not provide clear and detailed anatomical information, advanced imaging methods can be used., Aim: The aim of this study was to evaluate the diagnostic performance of deep learning (DL) applications that assess the relationship of the MSF to the first maxillary molar teeth (fMMT) and second maxillary molar teeth (sMMT) on PRs with data confirmed by cone beam computed tomography (CBCT)., Methods: A total of 2162 fMMT and sMMT were included in this retrospective study. The contact relationship of teeth with MSF was compared among DL methods., Results: DL methods, such as GoogLeNet, VGG16, VGG19, DarkNet19, and DarkNet53, were used to evaluate the contact relationship between MMT and MSF, and 85.89% accuracy was achieved by majority voting. In addition, 88.72%, 81.19%, 89.39%, and 83.14% accuracy rates were obtained in right fMMT, right sMMT, left fMMT, and left sMMT, respectively., Conclusion: DL models showed high accuracy values in detecting the relationship of fMMT and sMMT with MSF., (Copyright © 2024 Copyright: © 2024 Nigerian Journal of Clinical Practice.)

Objectives: To develop an automatic computer-based method that can help clinicians in assessing spine growth potential based on EOS radiographs., Methods: We developed a deep learning-based (DL) algorithm that can mimic the human judgment process to automatically determine spine growth potential and the Risser sign based on full-length spine EOS radiographs. A total of 3383 EOS cases were collected and used for the training and test of the algorithm. Subsequently, the completed DL algorithm underwent clinical validation on an additional 440 cases and was compared to the evaluations of four clinicians., Results: Regarding the Risser sign, the weighted kappa value of our DL algorithm was 0.933, while that of the four clinicians ranged from 0.909 to 0.930. In the assessment of spine growth potential, the kappa value of our DL algorithm was 0.944, while the kappa values of the four clinicians were 0.916, 0.934, 0.911, and 0.920, respectively. Furthermore, our DL algorithm obtained a slightly higher accuracy (0.973) and Youden index (0.952) compared to the best values achieved by the four clinicians. In addition, the speed of our DL algorithm was 15.2 ± 0.3 s/40 cases, much faster than the inference speeds of the clinicians, ranging from 177.2 ± 28.0 s/40 cases to 241.2 ± 64.1 s/40 cases., Conclusions: Our algorithm demonstrated comparable or even better performance compared to clinicians in assessing spine growth potential. This stable, efficient, and convenient algorithm seems to be a promising approach to assist doctors in clinical practice and deserves further study., Clinical Relevance Statement: This method has the ability to quickly ascertain the spine growth potential based on EOS radiographs, and it holds promise to provide assistance to busy doctors in certain clinical scenarios., Key Points: • In the clinic, there is no available computer-based method that can automatically assess spine growth potential. • We developed a deep learning-based method that could automatically ascertain spine growth potential. • Compared with the results of the clinicians, our algorithm got comparable results., (© 2023. The Author(s), under exclusive licence to European Society of Radiology.)

Almost 35 years after its introduction, coronary artery calcium score (CACS) not only survived technological advances but became one of the cornerstones of contemporary cardiovascular imaging. Its simplicity and quantitative nature established it as one of the most robust approaches for atherosclerotic cardiovascular disease risk stratification in primary prevention and a powerful tool to guide therapeutic choices. Groundbreaking advances in computational models and computer power translated into a surge of artificial intelligence (AI)-based approaches directly or indirectly linked to CACS analysis. This review aims to provide essential knowledge on the AI-based techniques currently applied to CACS, setting the stage for a holistic analysis of the use of these techniques in coronary artery calcium imaging. While the focus of the review will be detailing the evidence, strengths, and limitations of end-to-end CACS algorithms in electrocardiography-gated and non-gated scans, the current role of deep-learning image reconstructions, segmentation techniques, and combined applications such as simultaneous coronary artery calcium and pulmonary nodule segmentation, will also be discussed., (© 2024. The Author(s).)

Thyroid nodules are a common occurrence, and although most are non-cancerous, some can be malignant. The American College of Radiology has developed the Thyroid Imaging Reporting and Data System (TI-RADS) to standardize the interpretation and reporting of thyroid ultrasound results. Within TI-RADS, a category 4 designation signifies a thyroid nodule with an intermediate level of suspicion for malignancy. Accurate classification of these nodules is crucial for proper management, as it can potentially reduce unnecessary surgeries and improve patient outcomes. This study utilized deep learning techniques to effectively classify TI-RADS category 4 thyroid nodules as either benign or malignant. A total of 500 patients were included in the study and randomly divided into a training group (350 patients) and a test group (150 patients). The YOLOv3 model was constructed and evaluated using various metrics, achieving an 84% accuracy in the classification of TI-RADS category 4 thyroid nodules. Based on the predictions of the model, along with clinical and ultrasound data, a nomogram was developed. The performance of the nomogram was superior in both the training and testing groups. Furthermore, the calibration curve demonstrated good agreement between predicted probabilities and actual outcomes. Decision curve analysis further confirmed that the nomogram provided greater net benefits. Ultimately, the YOLOv3 model and nomogram successfully improved the accuracy of distinguishing between benign and malignant TI-RADS category 4 thyroid nodules, which is crucial for proper management and improved patient outcomes., (© 2024. The Author(s).)

Objectives: This study aimed to propose a deep learning (DL)-based framework for identifying the composition of thyroid nodules and assessing their malignancy risk., Methods: We conducted a retrospective multicenter study using ultrasound images from four hospitals. Convolutional neural network (CNN) models were constructed to classify ultrasound images of thyroid nodules into solid and non-solid, as well as benign and malignant. A total of 11,201 images of 6784 nodules were used for training, validation, and testing. The area under the receiver-operating characteristic curve (AUC) was employed as the primary evaluation index., Results: The models had AUCs higher than 0.91 in the benign and malignant grading of solid thyroid nodules, with the Inception-ResNet AUC being the highest at 0.94. In the test set, the best algorithm for identifying benign and malignant thyroid nodules had a sensitivity of 0.88, and a specificity of 0.86. In the human vs. DL test set, the best algorithm had a sensitivity of 0.93, and a specificity of 0.86. The Inception-ResNet model performed better than the senior physicians (p < 0.001). The sensitivity and specificity of the optimal model based on the external test set were 0.90 and 0.75, respectively., Conclusions: This research demonstrates that CNNs can assist thyroid nodule diagnosis and reduce the rate of unnecessary fine-needle aspiration (FNA)., Clinical Relevance Statement: High-resolution ultrasound has led to increased detection of thyroid nodules. This results in unnecessary fine-needle aspiration and anxiety for patients whose nodules are benign. Deep learning can solve these problems to some extent., Key Points: • Thyroid solid nodules have a high probability of malignancy. • Our models can improve the differentiation between benign and malignant solid thyroid nodules. • The differential performance of one model was superior to that of senior radiologists. Applying this could reduce the rate of unnecessary fine-needle aspiration of solid thyroid nodules., (© 2023. The Author(s), under exclusive licence to European Society of Radiology.)

Background: Precapillary pulmonary hypertension (PH) is characterized by a sustained increase in right ventricular (RV) afterload, impairing systolic function. Two-dimensional (2D) echocardiography is the most performed cardiac imaging tool to assess RV systolic function; however, an accurate evaluation requires expertise. We aimed to develop a fully automated deep learning (DL)-based tool to estimate the RV ejection fraction (RVEF) from 2D echocardiographic videos of apical four-chamber views in patients with precapillary PH., Methods: We identified 85 patients with suspected precapillary PH who underwent cardiac magnetic resonance imaging (MRI) and echocardiography. The data was divided into training (80%) and testing (20%) datasets, and a regression model was constructed using 3D-ResNet50. Accuracy was assessed using five-fold cross validation., Results: The DL model predicted the cardiac MRI-derived RVEF with a mean absolute error of 7.67%. The DL model identified severe RV systolic dysfunction (defined as cardiac MRI-derived RVEF < 37%) with an area under the curve (AUC) of .84, which was comparable to the AUC of RV fractional area change (FAC) and tricuspid annular plane systolic excursion (TAPSE) measured by experienced sonographers (.87 and .72, respectively). To detect mild RV systolic dysfunction (defined as RVEF ≤ 45%), the AUC from the DL-predicted RVEF also demonstrated a high discriminatory power of .87, comparable to that of FAC (.90), and significantly higher than that of TAPSE (.67)., Conclusion: The fully automated DL-based tool using 2D echocardiography could accurately estimate RVEF and exhibited a diagnostic performance for RV systolic dysfunction comparable to that of human readers., (© 2024 Wiley Periodicals LLC.)

Objectives: Evaluation of in-stent restenosis (ISR), especially for small stents, remains challenging during computed tomography (CT) angiography. We used deep learning reconstruction to quantify stent strut thickness and lumen vessel diameter at the stent and compared it with values obtained using conventional reconstruction strategies., Methods: We examined 166 stents in 85 consecutive patients who underwent CT and invasive coronary angiography (ICA) within 3 months of each other from 2019-2021 after percutaneous coronary intervention with coronary stent placement. The presence of ISR was defined as percent diameter stenosis ≥ 50% on ICA. We compared a super-resolution deep learning reconstruction, Precise IQ Engine (PIQE), and a model-based iterative reconstruction, Forward projected model-based Iterative Reconstruction SoluTion (FIRST). All images were reconstructed using PIQE and FIRST and assessed by two blinded cardiovascular radiographers., Results: PIQE had a larger full width at half maximum of the lumen and smaller strut than FIRST. The image quality score in PIQE was higher than that in FIRST (4.2 ± 1.1 versus 2.7 ± 1.2, p < 0.05). In addition, the specificity and accuracy of ISR detection were better in PIQE than in FIRST (p < 0.05 for both), with particularly pronounced differences for stent diameters < 3.0 mm., Conclusion: PIQE provides superior image quality and diagnostic accuracy for ISR, even with stents measuring < 3.0 mm in diameter., Clinical Relevance Statement: With improvements in the diagnostic accuracy of in-stent stenosis, CT angiography could become a gatekeeper for ICA in post-stenting cases, obviating ICA in many patients after recent stenting with infrequent ISR and allowing non-invasive ISR detection in the late phase., Key Points: • Despite CT technology advancements, evaluating in-stent stenosis severity, especially in small-diameter stents, remains challenging. • Compared with conventional methods, the Precise IQ Engine uses deep learning to improve spatial resolution. • Improved diagnostic accuracy of CT angiography helps avoid invasive coronary angiography after coronary artery stenting., (© 2023. The Author(s), under exclusive licence to European Society of Radiology.)

Water, an invaluable and non-renewable resource, plays an indispensable role in human survival and societal development. Accurate forecasting of water quality involves early identification of future pollutant concentrations and water quality indices, enabling evidence-based decision-making and targeted environmental interventions. The emergence of advanced computational technologies, particularly deep learning, has garnered considerable interest among researchers for applications in water quality prediction because of its robust data analytics capabilities. This article comprehensively reviews the deployment of deep learning methodologies in water quality forecasting, encompassing single-model and mixed-model approaches. Additionally, we delineate optimization strategies, data fusion techniques, and other factors influencing the efficacy of deep learning-based water quality prediction models, because understanding and mastering these factors are crucial for accurate water quality prediction. Although challenges such as data scarcity, long-term prediction accuracy, and limited deployments of large-scale models persist, future research aims to address these limitations by refining prediction algorithms, leveraging high-dimensional datasets, evaluating model performance, and broadening large-scale model application. These efforts contribute to precise water resource management and environmental conservation., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Renal pathologies often manifest as alterations in kidney size, providing a valuable avenue for employing dynamic parametric MRI as a means to derive kidney size measurements for the diagnosis, treatment, and monitoring of renal disease. Furthermore, this approach holds significant potential in supporting MRI data-driven preclinical investigations into the intricate mechanisms underlying renal pathophysiology. The integration of deep learning algorithms is crucial in achieving rapid and precise segmentation of the kidney from temporally resolved parametric MRI, facilitating the use of kidney size as a meaningful (pre)clinical biomarker for renal disease. To explore this potential, we employed dynamic parametric T 2 mapping of the kidney in rats in conjunction with a custom-tailored deep dilated U-Net (DDU-Net) architecture. The architecture was trained, validated, and tested on manually segmented ground truth kidney data, with benchmarking against an analytical segmentation model and a self-configuring no new U-Net. Subsequently, we applied our approach to in vivo longitudinal MRI data, incorporating interventions that emulate clinically relevant scenarios in rats. Our approach achieved high performance metrics, including a Dice coefficient of 0.98, coefficient of determination of 0.92, and a mean absolute percentage error of 1.1% compared with ground truth. The DDU-Net enabled automated and accurate quantification of acute changes in kidney size, such as aortic occlusion (-8% ± 1%), venous occlusion (5% ± 1%), furosemide administration (2% ± 1%), hypoxemia (-2% ± 1%), and contrast agent-induced acute kidney injury (11% ± 1%). This approach can potentially be instrumental for the development of dynamic parametric MRI-based tools for kidney disorders, offering unparalleled insights into renal pathophysiology., (© 2023 The Authors. NMR in Biomedicine published by John Wiley & Sons Ltd.)

Objectives: There is a need for CT pulmonary angiography (CTPA) lung segmentation models. Clinical translation requires radiological evaluation of model outputs, understanding of limitations, and identification of failure points. This multicentre study aims to develop an accurate CTPA lung segmentation model, with evaluation of outputs in two diverse patient cohorts with pulmonary hypertension (PH) and interstitial lung disease (ILD)., Methods: This retrospective study develops an nnU-Net-based segmentation model using data from two specialist centres (UK and USA). Model was trained (n = 37), tested (n = 12), and clinically evaluated (n = 176) on a diverse 'real-world' cohort of 225 PH patients with volumetric CTPAs. Dice score coefficient (DSC) and normalised surface distance (NSD) were used for testing. Clinical evaluation of outputs was performed by two radiologists who assessed clinical significance of errors. External validation was performed on heterogenous contrast and non-contrast scans from 28 ILD patients., Results: A total of 225 PH and 28 ILD patients with diverse demographic and clinical characteristics were evaluated. Mean accuracy, DSC, and NSD scores were 0.998 (95% CI 0.9976, 0.9989), 0.990 (0.9840, 0.9962), and 0.983 (0.9686, 0.9972) respectively. There were no segmentation failures. On radiological review, 82% and 71% of internal and external cases respectively had no errors. Eighteen percent and 25% respectively had clinically insignificant errors. Peripheral atelectasis and consolidation were common causes for suboptimal segmentation. One external case (0.5%) with patulous oesophagus had a clinically significant error., Conclusion: State-of-the-art CTPA lung segmentation model provides accurate outputs with minimal clinical errors on evaluation across two diverse cohorts with PH and ILD., Clinical Relevance: Clinical translation of artificial intelligence models requires radiological review and understanding of model limitations. This study develops an externally validated state-of-the-art model with robust radiological review. Intended clinical use is in techniques such as lung volume or parenchymal disease quantification., Key Points: • Accurate, externally validated CT pulmonary angiography (CTPA) lung segmentation model tested in two large heterogeneous clinical cohorts (pulmonary hypertension and interstitial lung disease). • No segmentation failures and robust review of model outputs by radiologists found 1 (0.5%) clinically significant segmentation error. • Intended clinical use of this model is a necessary step in techniques such as lung volume, parenchymal disease quantification, or pulmonary vessel analysis., (© 2023. The Author(s).)

Background: Studies on computed tomography (CT) synthesis based on magnetic resonance imaging (MRI) have mainly focused on pixel-wise consistency, but the texture features of regions of interest (ROIs) have not received appropriate attention., Purpose: This study aimed to propose a novel loss function to reproduce texture features of ROIs and pixel-wise consistency for deep learning-based MRI-to-CT synthesis. The method was expected to assist the multi-modality studies for radiomics., Methods: The study retrospectively enrolled 127 patients with nasopharyngeal carcinoma. CT and MRI images were collected for each patient, and then rigidly registered as pre-procession. We proposed a gray-level co-occurrence matrix (GLCM)-based loss function to improve the reproducibility of texture features. This novel loss function could be embedded into the present deep learning-based framework for image synthesis. In this study, a typical image synthesis model was selected as the baseline, which contained a Unet trained mean square error (MSE) loss function. We embedded the proposed loss function and designed experiments to supervise different ROIs to prove its effectiveness. The concordance correlation coefficient (CCC) of the GLCM feature was employed to evaluate the reproducibility of GLCM features, which are typical texture features. Besides, we used a publicly available dataset of brain tumors to verify our loss function., Results: Compared with the baseline, the proposed method improved the pixel-wise image quality metrics (MAE: 107.5 to 106.8 HU; SSIM: 0.9728 to 0.9730). CCC values of the GLCM features in GTVnx were significantly improved from 0.78 ± 0.12 to 0.82 ± 0.11 (p < 0.05 for paired t-test). Generally, > 90% (22/24) of the GLCM-based features were improved compared with the baseline, where the Informational Measure of Correlation feature was improved the most (CCC: 0.74 to 0.83). For the public dataset, the loss function also shows its effectiveness. With our proposed loss function added, the ability to reproduce texture features was improved in the ROIs., Conclusions: The proposed method reproduced texture features for MRI-to-CT synthesis, which would benefit radiomics studies based on image multi-modality synthesis., (© 2023 American Association of Physicists in Medicine.)