1. Microvessel density, a surrogate marker of angiogenesis, is significantly related to survival in multiple myeloma patients.
- Author
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Pruneri, Giancarlo, Ponzoni, Maurilio, Ferreri, Andrés J. M., Decarli, Nicola, Tresoldi, Moreno, Raggi, Francesca, Baldessari, Chiara, Freschi, Massimo, Baldini, Luca, Goldaniga, Maria, Neri, Antonino, Carboni, Nadia, Bertolini, Francesco, and Viale, Giuseppe
- Subjects
NEOVASCULARIZATION ,MULTIPLE myeloma ,PROGNOSIS ,PATIENTS - Abstract
Summary. We evaluated microvessel density (MVD) in bone marrow biopsies (BM) from multiple myeloma (MM) patients after staining with anti-CD34 and anti-CD105 antibodies (mAbs). The anti-CD105 mAb was significantly more sensitive than the anti-CD34 mAb in visualizing blood vessels both in controls and MM samples. MVD was significantly higher in MM than in controls with both anti-CD34 and anti-CD105 mAbs. Patients with low CD34
+ MVD survived longer than patients with higher MVD (P = 0·01), whereas there was no difference in survival between patients with low and high CD105+ MVD. Multivariate analysis confirmed the independent significant association between CD34+ MVD and survival (P = 0·001). [ABSTRACT FROM AUTHOR]- Published
- 2002
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