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Microvessel density, a surrogate marker of angiogenesis, is significantly related to survival in multiple myeloma patients.
- Source :
- British Journal of Haematology; Sep2002, Vol. 118 Issue 3, p817-820, 4p
- Publication Year :
- 2002
-
Abstract
- Summary. We evaluated microvessel density (MVD) in bone marrow biopsies (BM) from multiple myeloma (MM) patients after staining with anti-CD34 and anti-CD105 antibodies (mAbs). The anti-CD105 mAb was significantly more sensitive than the anti-CD34 mAb in visualizing blood vessels both in controls and MM samples. MVD was significantly higher in MM than in controls with both anti-CD34 and anti-CD105 mAbs. Patients with low CD34<superscript>+</superscript> MVD survived longer than patients with higher MVD (P = 0·01), whereas there was no difference in survival between patients with low and high CD105<superscript>+</superscript> MVD. Multivariate analysis confirmed the independent significant association between CD34<superscript>+</superscript> MVD and survival (P = 0·001). [ABSTRACT FROM AUTHOR]
- Subjects :
- NEOVASCULARIZATION
MULTIPLE myeloma
PROGNOSIS
PATIENTS
Subjects
Details
- Language :
- English
- ISSN :
- 00071048
- Volume :
- 118
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- British Journal of Haematology
- Publication Type :
- Academic Journal
- Accession number :
- 7171838
- Full Text :
- https://doi.org/10.1046/j.1365-2141.2002.03654.x