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Multicomponent Synthesis of 5-Cyano-pyrazolo[1,5-a]pyrimidines Enabled by Aerobic Manganese Catalysis Keywords: Manganese catalysis; Strecker reaction; Multicomponent reaction; Cyanation EN Manganese catalysis Strecker reaction Multicomponent reaction Cyanation 871 876 6 03/27/23 20230321 NES 230321 An aerobic Mn(III)-catalyzed one-pot three-component synthesis of 5-cyano-pyrazolo[1,5- I a i ]pyrimidines has been described. These results revealed that the tandem reaction starts with the Strecker reaction and Mn(OAc) SB 3 sb - 2H SB 2 sb O is essential in the following oxidative cyclization process. All of these control experiments strongly support that this tandem reaction involves the Strecker reaction and the sequential Mn-catalyzed cyclization to afford the desired product B 4 aa b . [Extracted from the article]

The front cover picture, provided by Sen Liang, Kun Xu, Cheng‐Chu Zeng, Hong‐Yu Tian, Bao‐Guo Sun, exhibits the advances in using electrochemistry for α‐C−H oxidative functionalization of carbonyl compounds. α‐C−H bond functionalization of carbonyl compounds to afford more versatile functionalized groups has become a promising strategy for atom‐economical C−C and C−X bond formation. Organic electrosynthesis is revolutionizing the way of organic synthesis, and this field has seen explosive growth in recent years. Details can be found in the review on pages 4266–4292 (S. Liang, K. Xu, C.‐C. Zeng, H.‐Y. Tian, B.‐G. Sun, Adv. Synth. Catal. 2018, 360, 4266–4292; DOI: 10.1002/adsc.201800519). [ABSTRACT FROM AUTHOR]

The scalable method represents the first coupling of aryl tetrazoles with mono and 1,1-disubstituted allenes. [ABSTRACT FROM AUTHOR]

An abstract of the article "Regio- and Enantioselective Synthesis of N-Substituted Pyrazoles by Rhodium-Catalyzed Asymmetric Addition to Allenes" by A. M. Haydl and colleagues is presented.

The scalable transformation is based on a benzoic acid/rhodium-catalyst system which affords branched allylic sulfones with good to excellent yields and selectivities. [ABSTRACT FROM AUTHOR]

A library of easily tunable, sterically bulky ligands is synthesized among which the one shown causes the highest conversions and enantiomeric excesses for the products as well as the best ratio of branched to linear products. [ABSTRACT FROM AUTHOR]

In course of this study the reaction is also conducted in water for the first time. [ABSTRACT FROM AUTHOR]

The scalable title reaction tolerates variously functionalized 2H-[1,2′-bipyridin]-2-ones as well as aryl and hetaryl substituted propargyl alcohols, but no alkyl substituted derivatives of the latter. [ABSTRACT FROM AUTHOR]

Anthranilic acid amides are cyclized to the corresponding dihydro-quinazolinones in good yields with dicumyl peroxide as radical methyl donor. [ABSTRACT FROM AUTHOR]

N-Methyl pyrrole, furan and thiophene do not react with (Ia). [ABSTRACT FROM AUTHOR]

2-Aryloylpyridines or quinolines efficiently react with aryl or alkyl substituted α-amino acids, thus offering not only a novel approach to 1,3-diaryl substituted imidazo[1,5-a]pyridines, but also to 3-alkyl-1-aryl substituted derivatives which are difficult to access by previously developed methods. [ABSTRACT FROM AUTHOR]

An efficient Cu(II)-catalyzed oxidative amination of sp3 C-H bonds using air as the terminal oxidant is presented. [ABSTRACT FROM AUTHOR]

The article presents chemical equations related to the article "Cerium(III)-Catalyzed Cascade Cyclization: An Efficient Approach to Functionalized Pyrrolo[1,2-a]quinolines" by C. Feng and others, published in the periodical "Organic & Biomolecular Chemistry" in 2014.