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Multicomponent Synthesis of 5‐Cyano‐pyrazolo[1,5‐a]pyrimidines Enabled by Aerobic Manganese Catalysis.
- Source :
- Advanced Synthesis & Catalysis; 3/21/2023, Vol. 365 Issue 6, p871-876, 6p
- Publication Year :
- 2023
-
Abstract
- Multicomponent Synthesis of 5-Cyano-pyrazolo[1,5-a]pyrimidines Enabled by Aerobic Manganese Catalysis Keywords: Manganese catalysis; Strecker reaction; Multicomponent reaction; Cyanation EN Manganese catalysis Strecker reaction Multicomponent reaction Cyanation 871 876 6 03/27/23 20230321 NES 230321 An aerobic Mn(III)-catalyzed one-pot three-component synthesis of 5-cyano-pyrazolo[1,5- I a i ]pyrimidines has been described. These results revealed that the tandem reaction starts with the Strecker reaction and Mn(OAc) SB 3 sb - 2H SB 2 sb O is essential in the following oxidative cyclization process. All of these control experiments strongly support that this tandem reaction involves the Strecker reaction and the sequential Mn-catalyzed cyclization to afford the desired product B 4 aa b . [Extracted from the article]
Details
- Language :
- English
- ISSN :
- 16154150
- Volume :
- 365
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Advanced Synthesis & Catalysis
- Publication Type :
- Academic Journal
- Accession number :
- 162644768
- Full Text :
- https://doi.org/10.1002/adsc.202201361