1. Cytotoxic lanostane triterpenoids from the stems of Schisandra glaucescens.
- Author
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Liu, Yan, Hu, Jiang, Lv, Yan, Huang, Xiao-Yun, and Zhang, Guo-Xu
- Subjects
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ANTINEOPLASTIC agents , *CELL lines , *CELL surface antigens , *CHROMATOGRAPHIC analysis , *HIGH performance liquid chromatography , *IMMUNODIAGNOSIS , *MOLECULAR structure , *NUCLEAR magnetic resonance spectroscopy , *STATISTICS , *TERPENES , *PLANT extracts , *DATA analysis , *PLANT anatomy , *IN vitro studies - Abstract
Phytochemical investigation on the stems of Schisandra glaucescens resulted into the isolation of three new lanostane triterpenoids, 12-hydroxyschiglausin B (1), 12-hydroxykadsuphilactone B (2), and 20R-hydroxyschinalactone C (3). Structural elucidation of all the compounds was accomplished by spectral methods. The isolated compounds were tested in vitro for cytotoxic activities. As a result, triterpenoids 1 and 2 showed cytotoxic activities for all six tested tumor cell lines with IC50 values less than 15 μM. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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