663 results on '"Xu, Liang"'
Search Results
2. A multi convolution pooling group fault diagnosis model with high generalization across data sets and large receptive field characteristics considering industrial environmental noise.
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Pan, Wujiu, Cao, Shuming, Xu, Liang, Sun, YingHao, and Nie, Peng
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CONVOLUTIONAL neural networks ,FEATURE extraction ,FAULT diagnosis ,DEEP learning ,ROLLER bearings - Abstract
Considering the noise impact in the bearing operating environment and the time-consuming and non-universal design of traditional diagnostic algorithms, this paper proposes a new model for rolling bearing fault diagnosis, which uses convolutional pooling group (CPG) to extract features from data, At the same time, expanding the dual convolutional kernel to obtain a larger receptive field obtained the WCPGCNN (A CPG Convolutional Neural Network with Wide Convolutional Kernel as the First Lay) model based on the CPG network architecture. Firstly, the fault features of the input signal are automatically extracted through four convolutional pooling groups; Next, fault features are further extracted using the fully connected layer, and finally input into the Softmax layer for fault identification. By utilizing algorithms such as Adam, dropout, and batch normalization, the model performs well in terms of accuracy, noise resistance, and timeliness, while also possessing good cross dataset high generalization ability. This article uses the rolling bearing fault standard data from Case Western Reserve University (CWRU) and the American Society for Mechanical Fault Prevention Technology (MFPT), and verifies through multiple controlled experiments that the model established in this article has high accuracy and good generalization characteristics. [ABSTRACT FROM AUTHOR]
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- 2024
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3. Drilling performance of small holes on Cf/SiC composites with brazed diamond grinding rods.
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Wang, Kai, Sun, Qiaoru, Yang, Haotian, Jiao, Xingjian, Wang, Xinyong, Li, Junping, Xu, Liang, and Zhao, Guolong
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Carbon fiber reinforced silicon carbide matrix composites (C
f /SiC composites) are lightweight, high strength, wear-resistant, and heat-resistant, making them widely used in aerospace and other industries. However, machining holes in Cf /SiC composites is a great challenge due to the anisotropy and high hardness of the material. In this paper, a brazed diamond grinding rod was employed to grind 1 mm diameter holes in Cf /SiC composites, and the influence of grinding parameters on grinding force, hole entrance/exit defects, and hole wall quality was investigated. In addition, the material removal mechanism of Cf /SiC composites and the wear mechanism of the diamond grinding rod were explored. The findings showed that the damage at the hole entrance and exit predominantly manifests as tearing and burring. The damage factor at the hole exit is 3.5% larger than that at the hole entrance, and the damage factor at both the hole entrance and exit reduces with the growth of spindle speed and the decrease of feed rate. In addition, the diameter errors of the hole entrances and exits are all less than 10%, and the entrance diameter is 2.9% larger than the exit. The hole wall defects include fiber fracture, silicon carbide matrix peeling, and inherent porosity, with poorer surface quality at fiber orientation angles (FOA) of 90° to 180°. The main wear mechanisms were identified as abrasive wear and the spalling of abrasive grains. [ABSTRACT FROM AUTHOR]- Published
- 2024
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4. Real-space imaging for discovering a rotated node structure in metal-organic framework.
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Feng, Jiale, Feng, Zhipeng, Xu, Liang, Meng, Haibing, Chen, Xiao, Ma, Mengmeng, Wang, Lei, Song, Bin, Tang, Xuan, Dai, Sheng, Wei, Fei, Cheng, Tao, and Shen, Boyuan
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METAL-organic frameworks ,POROUS materials ,SURFACE defects ,ATOMIC structure ,IMAGE analysis - Abstract
Resolving the detailed structures of metal organic frameworks is of great significance for understanding their structure-property relation. Real-space imaging methods could exhibit superiority in revealing not only the local structure but also the bulk symmetry of these complex porous materials, compared to reciprocal-space diffraction methods, despite the technical challenges. Here we apply a low-dose imaging technique to clearly resolve the atomic structures of building units in a metal-organic framework, MIL-125. An unexpected node structure is discovered by directly imaging the rotation of Ti-O nodes, different from the unrotated structure predicted by previous X-ray diffraction. The imaged structure and symmetry can be confirmed by the structural simulations and energy calculations. Then, the distribution of node rotation from the edge to the center of a MIL-125 particle is revealed by the image analysis of Ti-O rotation. The related defects and surface terminations in MIL-125 are also investigated in the real-space images. These results not only unraveled the node symmetry in MIL-125 with atomic resolution but also inspired further studies on discovering more unpredicted structural changes in other porous materials by real-space imaging methods. Resolving the structures of MOFs is significant for understanding their structure-property relation. Here, authors apply a low-dose imaging technique to resolve the atomic structures of building units in MOF MIL-125. A low-symmetry structure of MIL-125 is discovered by directly imaging the rotated Ti-O nodes, different from the unrotated one predicted in previous works. [ABSTRACT FROM AUTHOR]
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- 2024
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5. High-resolution remote thermometry based on Bi3+-doped 0D zinc halide hybrids.
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Shi, Cui-Mi, Xue, Shu-Hua, Wang, Jin-Yun, Xu, Liang-Jin, and Chen, Zhong-Ning
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Developing highly sensitive optical thermometers is of great significance due to their capability to enable remote and non-contact temperature measurements, rendering them highly applicable in diverse and harsh environments. Herein we report a temperature-dependent phosphor of 0D metal halide hybrid by incorporating Bi
3+ into the (MePPh3 )2 ZnCl4 matrix. Through Bi3+ doping, the initially non-luminescent (MePPh3 )2 ZnCl4 matrix exhibits a deep-blue emission centered at 453 nm, with a photoluminescence quantum yield (PLQY) of 5.71% and a Stokes shift of 75 nm at room temperature. Experimental characterization demonstrates that exciton-like luminescence of Bi3+ is mainly responsible for the blue emission. Single crystals of Bi3+ -doped (MePPh3 )2 ZnCl4 show an unusual correlation between photoluminescence (PL) lifetime and temperature. Particularly, the dependence of luminescence lifetime on temperature is most remarkable in the temperature range of 80 to 100 K with an exceptional sensitivity up to 0.09 K−1 , representing one of the best levels for thermometry based on PL decay lifetime. Our work not only provides a viable strategy for designing a novel, environmentally friendly, and stable blue emitter, but also paves the way for precise thermometric application at low temperature. [ABSTRACT FROM AUTHOR]- Published
- 2024
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6. Super-high bed sintering for iron ores: inhomogeneous phenomena and its mechanism during mineralizing.
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Liu, Hui-bo, Xu, Liang-ping, Yang, Xi-duan, Dong, Zhong-lin, Zhong, Qiang, and Li, Guang-hui
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- 2024
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7. Extended State Observer Based Generalized Predictive Control for Aircraft at High Angle of Attack.
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Liu, Junjie, Ji, Yuehui, Xu, Liang, and Chen, Zengqiang
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This paper presents a linear compound control strategy for nonlinear aircraft system at high angle of attack. Firstly, extended state observers are designed to overcome model dependence by estimating and compensating the total disturbances including the parameters uncertainties and strong coupling among channels. Secondly, the controlled subsystems are approximately converted to linear integrals based on dynamics compensation linearization, respectively. Subsequently, the generalized predictive controllers are designed based on the integral type prediction model instead of solving the Diophantine equation online, which reduces the computation burden of inverse control incremental matrix. Finally, some simulation results and analysis for aircraft at high angle of attack are carried out to prove the effectiveness of the proposed control strategy. [ABSTRACT FROM AUTHOR]
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- 2024
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8. Regulation of nitrogen utilization and mycotoxin biosynthesis by the GATA transcription factor AaAreA in Alternaria alternata.
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Wang, Liuqing, Wang, Cheng, Xu, Liang, and Wang, Meng
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GATA proteins ,ALTERNARIA alternata ,TRANSCRIPTION factors ,BIOSYNTHESIS ,NUCLEAR transport ,FUNGAL growth - Abstract
Alternaria alternata is a prevalent postharvest pathogen that generates diverse mycotoxins, notably alternariol (AOH) and alternariol monomethyl ether (AME), which are recurrent severe contaminants. Nitrogen sources modulate fungal growth, development, and secondary metabolism, including mycotoxin production. The GATA transcription factor AreA regulates nitrogen source utilization. However, little is known about its involvement in the regulation of nitrogen utilization in A. alternata. To examine the regulatory mechanism of AaAreA on AOH and AME biosynthesis in A. alternata, we analyzed the impact of diverse nitrogen sources on the fungal growth, conidiation and mycotoxin production. The use of a secondary nitrogen source (NaNO
3 ) enhanced mycelial elongation and sporulation more than the use of a primary source (NH4 Cl). NaNO3 favored greater mycotoxin accumulation than did NH4 Cl. The regulatory roles of AaAreA were further clarified through gene knockout. The absence of AaAreA led to an overall reduction in growth in minimal media containing any nitrogen source except NH4 Cl. AaAreA positively regulates mycotoxin biosynthesis when both NH4 Cl and NaNO3 are used as nitrogen sources. Subcellular localization analysis revealed abundant nuclear transport when NaNO3 was the sole nitrogen source. The regulatory pathway of AaAreA was systematically revealed through comprehensive transcriptomic analyses. The deletion of AaAreA significantly impedes the transcription of mycotoxin biosynthetic genes, including aohR, pksI and omtI. The interaction between AaAreA and aohR, a pathway-specific transcription factor gene, demonstrated that AaAreA binds to the aohR promoter sequence (5'-GGCTATGGAAA-3'), activating its transcription. The expressed AohR regulates the expression of downstream synthase genes in the cluster, ultimately impacting mycotoxin production. This study provides valuable information to further understand how AreA regulates AOH and AME biosynthesis in A. alternata, thereby enabling the effective design of control measures for mycotoxin contamination. [ABSTRACT FROM AUTHOR]- Published
- 2024
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9. Stable zinc anode solid electrolyte interphase via inner Helmholtz plane engineering.
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Luo, Jinrong, Xu, Liang, Yang, Yinan, Huang, Song, Zhou, Yijing, Shao, Yanyan, Wang, Tianheng, Tian, Jiaming, Guo, Shaohua, Zhao, Jianqing, Zhao, Xiaoxu, Cheng, Tao, Shao, Yuanlong, and Zhang, Jin
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SOLID electrolytes ,SHAPED charges ,METALLIC surfaces ,METALWORK ,DENDRITES - Abstract
The inner Helmholtz plane and thus derived solid-electrolyte interphase (SEI) are crucial interfacial structure to determine the electrochemical stability of Zn-ion battery (ZIB). In this work, we demonstrate that introducing β-cyclodextrins (CD) as anion-receptors into Zn(OTf)
2 aqueous electrolyte could significantly optimize the Zn anode SEI structure for achieving stable ZIB. Specifically, β-CD with macrocyclic structure holds appropriate cavity size and charge distribution to encase OTf- anions at the Zn metal surface to form β-CD@OTf- dominated inner Helmholtz structure. Meanwhile, the electrochemically triggered β-CD@OTf- decomposition could in situ convert to the organic-inorganic hybrid SEI (ZnF2 /ZnCO3 /ZnS‒(C-O-C/* CF/* CF3 )), which could efficiently hinder the Zn dendrite growth with maintain the proper SEI mechanical strength stability to guarantee the long-term stability. The thus-derived Zn | |Zn pouch cell (21 cm2 size) with β-CD-containing electrolyte exhibits a cumulative capacity of 6450 mAh−2 cm−2 at conditions of 10 mAh cm−2 high areal capacity. This work gives insights for reaching stable ZIB via electrolyte additive triggered SEI structure regulation. Here, the authors report that introducing βcyclodextrins (CD) as anion-receptors into Zn(OTf)2 aqueous electrolyte could significantly optimize the Zn anode SEI structure for achieving stable ZIB. [ABSTRACT FROM AUTHOR]- Published
- 2024
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10. Exploring task-diverse meta-learning on Tibetan multi-dialect speech recognition.
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Liu, Yigang, Zhao, Yue, Xu, Xiaona, Xu, Liang, Zhang, Xubei, and Ji, Qiang
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SPEECH perception ,DIALECTS ,RECOGNITION (Psychology) ,TIBETANS ,PHONETICS - Abstract
The disparities in phonetics and corpuses across the three major dialects of Tibetan exacerbate the difficulty of a single task model for one dialect to accommodate other different dialects. To address this issue, this paper proposes task-diverse meta-learning. Our model can acquire more comprehensive and robust features, facilitating its adaptation to the variations among different dialects. This study uses Tibetan dialect ID recognition and Tibetan speaker recognition as the source tasks for meta-learning, which aims to augment the ability of the model to discriminate variations and differences among different dialects. Consequently, the model's performance in Tibetan multi-dialect speech recognition tasks is enhanced. The experimental results show that task-diverse meta-learning leads to improved performance in Tibetan multi-dialect speech recognition. This demonstrates the effectiveness and applicability of task-diverse meta-learning, thereby contributing to the advancement of speech recognition techniques in multi-dialect environments. [ABSTRACT FROM AUTHOR]
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- 2024
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11. Inflammation-Responsive Mesoporous Silica Nanoparticles with Synergistic Anti-inflammatory and Joint Protection Effects for Rheumatoid Arthritis Treatment.
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Wu, Ye-zhen, Chen, Wen-yu, Zeng, Ying, Ji, Qi-lin, Yang, Yue, Guo, Xu-liang, and Wang, Xiu
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SILICA nanoparticles ,LABORATORY rats ,RHEUMATOID arthritis ,MICRODIALYSIS ,GLUCOSAMINE - Abstract
Purpose: Joint destruction is a major burden and an unsolved problem in rheumatoid arthritis (RA) patients. We designed an intra-articular mesoporous silica nanosystem (MSN-TP@PDA-GlcN) with anti-inflammatory and joint protection effects. The nanosystem was synthesized by encapsulating triptolide (TP) in mesoporous silica nanoparticles and coating it with pH-sensitive polydopamine (PDA) and glucosamine (GlcN) grafting on the PDA. The nano-drug delivery system with anti-inflammatory and joint protection effects should have good potency against RA. Methods: A template method was used to synthesize mesoporous silica (MSN). MSN-TP@PDA-GlcN was synthesized via MSN loading with TP, coating with PDA and grafting of GlcN on PDA. The drug release behavior was tested. A cellular inflammatory model and a rat RA model were used to evaluate the effects on RA. In vivo imaging and microdialysis (MD) system were used to analyze the sustained release and pharmacokinetics in RA rats. Results: TMSN-TP@PDA-GlcN was stable, had good biocompatibility, and exhibited sustained release of drugs in acidic environments. It had excellent anti-inflammatory effects in vitro and in vivo. It also effectively repaired joint destruction in vivo without causing any tissue toxicity. In vivo imaging and pharmacokinetics experiments showed that the nanosystem prolonged the residence time, lowered the C
max value and enhanced the relative bioavailability of TP. Conclusions: These results demonstrated that MSN-TP@PDA-GlcN sustained the release of drugs in inflammatory joints and produced effective anti-inflammatory and joint protection effects on RA. This study provides a new strategy for the treatment of RA. [ABSTRACT FROM AUTHOR]- Published
- 2024
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12. Coupled Cu doping and Z-scheme heterojunction for synergistically enhanced tetracycline photodegradation.
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Shen, Huidong, Yang, Chunming, Hong, Song, Hao, Leiduan, Xu, Liang, Robertson, Alex W., and Sun, Zhenyu
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TETRACYCLINE ,COPPER ,HETEROJUNCTIONS ,IRRADIATION ,ELECTRIC field effects ,TETRACYCLINES ,CLEAN energy ,SOLAR radiation - Abstract
Semiconductor-based photocatalysis by utilizing solar energy for sustainable organic pollutant elimination has been a promising tactic to alleviate environmental issues. Nevertheless, the development of robust and efficient photocatalysts to degrade organic pollutants still faces major challenges because of insufficient charge separation. Here we design and fabricate a heterojunction consisting of copper, carbon-modified TiO
2 , and sulfur-doped g-C3 N4 nanosheets (i.e., S-C3 N4 /Cu/C-TiO2 ). The heterostructure affords a remarkable synergistic photocatalysis for tetracycline hydrochloride degradation, achieving an 82.6% removal efficiency within 30 min under visible light irradiation, about 15.4 and 7.3 times higher than that of S-C3 N4 and C-TiO2 , respectively. The superior performance is attributed to the synergy between Cu doping and the Z-scheme heterojunction, which not only enhances the interfacial electric field effect, facilitating charge separation, but also boosts the redox capability. The charge carrier transfer between Cu/C-TiO2 and S-C3 N4 follows a Z-scheme, as verified by trapping experiments, electron spin-resonance spectroscopy, and density functional theory calculations. Furthermore, the tetracycline hydrochloride degradation pathways are enunciated by liquid chromatograph mass spectrometry analysis. This work provides an effective approach for constructing high-performance photocatalysts that have potential in environmental remediation. [ABSTRACT FROM AUTHOR]- Published
- 2024
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13. Super-high bed sintering for iron ores: behaviors, causes and solutions of horizontal segregation on strand.
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Xu, Liang-ping, Liu, Hui-bo, Dong, Zhong-lin, Zhong, Qiang, Zhao, Yu-chao, and Li, Guang-hui
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- 2024
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14. The conversion of monolignans to sesquilignans and dilignans is closely correlated to the regulation of Arctium lappa seed germination.
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Zhao, Rong, Yu, Ying, Gao, Mingze, Xing, Yanping, Xue, Jianing, Xu, Liang, and Kang, Tingguo
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Main conclusion: The secondary metabolic conversion of monolignans to sesquilignans/dilignans was closely related to seed germination and seedling establishment in Arctium lappa. Arctium lappa plants are used as a kind of traditional Chinese medicines for nearly 1500 years, and so far, only a few studies have put focus on the key secondary metabolic changes during seed germination and seedling establishment. In the current study, a combined approach was used to investigate the correlation among secondary metabolites, plant hormone signaling, and transcriptional profiles at the early critical stages of A. lappa seed germination and seedling establishment. Of 50 metabolites in methonolic extracts of A. lappa samples, 35 metabolites were identified with LC–MS/MS and 15 metabolites were identified with GC–MS. Their qualitative properties were examined according to the predicted chemical structures. The quantitative analysis was performed for deciphering their metabolic profiles, discovering that the secondary metabolic conversion from monolignans to sesquilignans/dilignans was closely correlated to the initiation of A. lappa seed germination and seedling establishment. Furthermore, the critical transcriptional changes in primary metabolisms, translational regulation at different cellular compartments, and multiple plant hormone signaling pathways were revealed. In addition, the combined approach provides unprecedented insights into key regulatory mechanisms in both gene transcription and secondary metabolites besides many known primary metabolites during seed germination of an important traditional Chinese medicinal plant species. The results not only provide new insights to understand the regulation of key medicinal components of 'ARCTII FRUCTUS', arctiin and arctigenin at the stages of seed germination and seedling establishment, but also potentially spur the development of seed-based cultivation in A. lappa plants. [ABSTRACT FROM AUTHOR]
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- 2024
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15. Bimetallic NiCoP catalysts anchored on phosphorus-doped lignin-based carbon for robust oxygen evolution performance.
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Xiong, Ling-Ying-Zi, Liu, Bo-Wen, Du, Lei, Zhou, Yue-Kuan, Lin, Xu-Liang, and Wang, Huan
- Abstract
Copyright of Rare Metals is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2024
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16. Association between sleep duration and the risk of hyperhomocysteinemia among adults in the United States: National Health and Nutrition Examination Survey, 2005–2006.
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Xu, Liang, Jia, Yuehui, and Xiao, Qiong
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The study aimed to discuss the association between sleep duration and the risk of hyperhomocysteinemia (Hhcy). This cross-sectional study included 4173 adults (≥ 20 years) from the National Health and Nutrition Examination Survey 2005–2006. According to their sleep duration, participants were divided into five subgroups. Multivariate logistic regression analysis models and restrictive cubic spline regressions were used to explore the association between sleep duration and the risk of Hhcy. Compared with the participants who sleep 7 h, sleep deprivation (≤ 5 h) increased the risk of Hhcy, odds ratio (OR) 1.68 (95% confidence interval (CI) 1.06–2.68); Excessive sleep (≥ 9 h) also increased the risk of Hhcy, OR 1.86 (95% CI 1.09–3.14) after adjusting for a series of confounding factors in the entire population. The risk of Hhcy was distributed in a U-shape with sleep duration. Similar results were demonstrated in obese populations. The association between sleep duration and the risk of Hhcy is U-shaped. Both sleep deprivation and excessive sleep can increase the risk of Hhcy. [ABSTRACT FROM AUTHOR]
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- 2024
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17. Phased progressive learning with coupling-regulation-imbalance loss for imbalanced data classification.
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Xu, Liang, Cheng, Yi, Zhang, Fan, Wu, Bingxuan, Shao, Pengfei, Liu, Peng, Shen, Shuwei, Yao, Peng, and Xu, Ronald X.
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CONVOLUTIONAL neural networks , *CLASSIFICATION - Abstract
Deep convolutional neural networks often perform poorly when faced with datasets that suffer from quantity imbalances and classification difficulties. Despite advances in the field, existing two-stage approaches still exhibit dataset bias or domain shift. To counter this, a phased progressive learning schedule has been proposed that gradually shifts the emphasis from representation learning to training the upper classifier. This approach is particularly beneficial for datasets with larger imbalances or fewer samples. Another new method a coupling-regulation-imbalance loss function is proposed, which combines three parts: a correction term, focal loss, and LDAM loss. This loss is effective in addressing quantity imbalances and outliers, while regulating the focus of attention on samples with varying classification difficulties. These approaches have yielded satisfactory results on several benchmark datasets, including Imbalanced CIFAR10, Imbalanced CIFAR100, ImageNet-LT, and iNaturalist 2018, and can be easily generalized to other imbalanced classification models. Deep convolutional neural networks often perform poorly when faced with datasets that suffer from quantity imbalances and classification difficulties. Despite advances in the field, existing two-stage approaches still exhibit dataset bias or domain shift. To counter this, a phased progressive learning schedule has been proposed that gradually shifts the emphasis from representation learning to training the upper classifier. This approach is particularly beneficial for datasets with larger imbalances or fewer samples. Another new method a coupling-regulation-imbalance loss function is proposed, which combines three parts: a correction term, focal loss, and LDAM loss. This loss is effective in addressing quantity imbalances and outliers, while regulating the focus of attention on samples with varying classification difficulties. These approaches have yielded satisfactory results on several benchmark datasets, including Imbalanced CIFAR10, Imbalanced CIFAR100, ImageNet-LT, and iNaturalist 2018, and can be easily generalized to other imbalanced classification models. [ABSTRACT FROM AUTHOR]
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- 2024
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18. The role of comfort, personality, and intention in smartwatch usage during sleep.
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Li, Hongting, Xu, Bingfei, Sun, Zaoyi, Yan, Rui, Wu, Yingchao, Zhang, Haimo, Zhou, Keyuan, and Xu, Liang
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SMARTWATCHES ,STRUCTURAL equation modeling ,PERSONALITY ,SLEEP ,SLEEP hygiene ,INTENTION - Abstract
The comfort of a smartwatch is recognized as a pivotal determinant affecting users' engagement with the device. This study delved into the intricate interplay between smartwatch comfort, users' behavioral intention, and their actual usage behavior within the specific context of sleep. Through the lens of a structural equation model, we find that the appearance and movement dimensions of comfort significantly influence users' intention to wear the smartwatch during sleep, while other dimensions like pressure, harm, attachment, and perceived change do not show significant effects. Furthermore, this intention significantly translated into smartwatch usage behavior. Building on these insights, we subsequently embarked on an exploration of how personality traits interplay with comfort and intention to impact smartwatch usage during sleep. The moderated mediation models revealed that the personality trait of openness acts as a moderator, amplifying the relationship between smartwatch comfort and behavioral intention. Individuals with higher levels of openness exhibit increased inclination to adopt the smartwatch during sleep, even when comfort is compromised. These insights contribute to a nuanced understanding of smartwatch usage behavior and offer guidance for personalized design strategies, especially within the sleep context. [ABSTRACT FROM AUTHOR]
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- 2024
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19. The association between pregnancy levels of blood lipids and the risk of preterm birth.
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Lv, Yao, Xu, Liang, He, Zhong, Liu, Xiaorui, and Guo, Yuna
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BLOOD lipids , *PREMATURE labor , *PREGNANT women , *PREGNANCY , *MULTIPLE pregnancy , *REPRODUCTIVE technology - Abstract
Preterm labor, a condition associated with various risk factors such as a history of prior preterm birth (PTB) and multiple pregnancies, has recently seen an increasing focus on its potential link with dyslipidemia. This study aims to investigate the relationship between dyslipidemia in expectant mothers and the risks of PTB. We studied 6963 mothers who gave birth at the International Peace Maternal and Child Health Hospital of Shanghai Jiaotong University School of Medicine in 2020, among which, 437 women had PTB. We extracted clinical and lipid data from electronic records, using multivariable logistic regression and restricted cubic spline models to explore the link between lipid concentrations (by quartiles) in pregnancy stages and PTB risk. The PTB rate was 6.3%. Early pregnancy in the PTB group showed elevated ApoA, ApoB, CHOL, LDL, and TG levels compared to controls (all P < 0.05). Late pregnancy showed no notable lipid differences. Multivariable analysis revealed elevated ApoA, TG, higher age, BMI ≥ 28 kg/m2, hypertension, assisted reproductive technology and gestational diabetes as PTB risk factors (all P < 0.05). After adjustments, higher ApoA, ApoB, CHOL and TG levels correlated with increased PTB risk. Using the lowest quartile, the adjusted ORs for early pregnancy's highest quartile of ApoA, ApoB, CHOL and TG were 1.348, 1.442, 1.442 and 2.156, respectively. Our findings indicate that dyslipemia in early pregnancy, including elevated levels of ApoA, ApoB, CHOL and TG, are associated with PTB. Managing lipid abnormalities during pregnancy may help reduce the risk of PTB. [ABSTRACT FROM AUTHOR]
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- 2024
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20. ATFTrans: attention-weighted token fusion transformer for robust and efficient object tracking.
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Xu, Liang, Wang, Liejun, and Guo, Zhiqing
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OBJECT tracking (Computer vision) , *TRANSFORMER models , *COMPUTATIONAL complexity , *RESEARCH personnel - Abstract
Recently, fully transformer-based trackers have achieved impressive tracking results, but this also brings a great deal of computational complexity. Some researchers have applied token pruning techniques to fully transformer-based trackers to diminish the computational complexity, but this leads to missing contextual information that is important for the regression task in the tracker. In response to the above issue, this paper proposes a token fusion method that speeds up inference while avoiding information loss and thus improving the robustness of the tracker. Specifically, the input of the transformer's encoder contains search tokens and exemplar tokens, and the search tokens are divided into tracking object tokens and background tokens according to the similarity between search tokens and exemplar tokens. The tokens with greater similarity to the exemplar tokens are identified as tracking object tokens, and those with smaller similarity to the exemplar tokens are identified as background tokens. The tracking object tokens contain the discriminative features of the tracking object, for the sake of making the tracker pay more attention to the tracking object tokens while reducing the computational effort. All the tracking object tokens are kept, and then, the background tokens are weighted and fused to form new background tokens according to the attention weight of the background tokens to prevent the loss of contextual information. The token fusion method presented in this paper not only provides efficient inference of the tracker but also makes the tracker more robust. Extensive experiments are carried out on popular tracking benchmark datasets to verify the validity of the token fusion method. [ABSTRACT FROM AUTHOR]
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- 2024
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21. Super-high bed sintering for iron ores: problems ascertainment.
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Xu, Liang-ping, Liu, Hui-bo, Zhao, Yu-chao, Zhong, Qiang, Dong, Zhong-lin, Li, Guang-hui, and Jiang, Tao
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- 2024
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22. Synthesis and Biological Evaluation of Arctigenin-Dipeptide Derivatives as Potential Anti-Fatigue Agents.
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Zeng, Wanbo, Li, Siyuan, Shi, Weiguo, Tan, Junjie, Li, Xiang, and Xu, Liang
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BIOSYNTHESIS ,BLOOD urea nitrogen ,LONG-distance running ,PHYSICAL mobility ,FATIGUE (Physiology) ,DIPEPTIDES ,LABOR productivity - Abstract
Fatigue is a physiological phenomenon experienced by the human body when it undergoes prolonged physical and mental exertion, which can have detrimental effects on both health and work productivity. Previous research has demonstrated that arctigenin (ArcG) has the ability to enhance the physical performance of mice during exercise. In this study, five ArcG derivatives containing different dipeptides coupled via an ethoxy linker were synthesized and tested for their activities to improve exercise performance in mice. All of the derivatives extended the exhaustion distance of mice in the running wheel test. Derivative Z-B-4 exhibited the highest activity, showing that the mice ran a distance 1.3-fold greater than that of the ArcG group and 3.4-fold greater than that of the sport control group. Furthermore, Z-B-4 was found to increase the concentrations of superoxide dismutase (SOD) and catalase (CAT), while simultaneously decreasing levels of lactic acid (LA) and blood urea nitrogen (BUN) during exercise. This study provides new references and promising lead compounds for the development of antifatigue agents. [ABSTRACT FROM AUTHOR]
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- 2024
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23. Characterization and Application of Membrane-emulsified HLB Microspheres for Quantification of 25-Hydroxy Vitamin D2 and 25-Hydroxy Vitamin D3 in Serum by UPLC-MS/MS.
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Zhang, Jihua, Gong, Zishan, Tie, Hang, Wang, Yanchun, Wang, Xuan, Zhai, Weixiang, Guo, Qiaoyun, Wu, Wenhui, Liu, Jiyang, Xu, Liang, Jing, Wenli, and Zhang, Shuo
- Abstract
Membrane emulsification can obtain microspheres with relatively uniform particle size and pore size, which has unique advantages in the synthesis of polymer microsphere adsorbents and the enrichment and separation of organic compounds. In this study, the Hydrophilic Lipophilic Balance (HLB) solid phase extraction microspheres were prepared by membrane emulsification technique and was used in the pretreatment of samples to detect 25-hydroxy vitamin D
2 (25OH-VD2 ) and 25-hydroxy vitamin D3 (25OH-VD3 ) in serum by UPLC-MS/MS for the first time. To confirm the efficacy of membrane-emulsified (ME) HLB microspheres, three types of microspheres, including ME HLB microspheres, non-membrane-emulsified (non-ME) HLB microspheres and commercial HLB microspheres, were compared for the pretreatment of 25OH-VD2 and 25OH-VD3 . The performance of HLB microspheres was characterized based on the sample recovery values acquired by UPLC-MS/MS analysis. Results showed that among the three types of microspheres, ME HLB microspheres showed the best performance and demonstrated good adsorption properties for 25OH-VD2 and 25OH-VD3 . The recoveries range of 25OH-VD2 and 25OH-VD3 were 96.7–101.4 and 98.7–104.9%, respectively, and the coefficients of variation were 0.67–1.24 and 1.39–2.28%, respectively, which were superior to those of commercial HLB microspheres and non-ME HLB microspheres. Additionally, due to their excellent homogeneity, the ME HLB microspheres exhibited good precision in the determination of low values of 25OH-VD2 and 25OH-VD3 , indicating accurate and simple detection of 25OH-VD2 and 25OH-VD3 with a broad potential for further development. [ABSTRACT FROM AUTHOR]- Published
- 2024
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24. Nanjing Yunjin intelligent question-answering system based on knowledge graphs and retrieval augmented generation technology.
- Author
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Xu, Liang, Lu, Lu, Liu, Minglu, Song, Chengxuan, and Wu, Lizhen
- Subjects
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QUESTION answering systems , *KNOWLEDGE graphs , *PROTECTION of cultural property , *LANGUAGE models , *INFORMATION technology , *KNOWLEDGE base - Abstract
Nanjing Yunjin, a traditional Chinese silk weaving craft, is celebrated globally for its unique local characteristics and exquisite workmanship, forming an integral part of the world's intangible cultural heritage. However, with the advancement of information technology, the experiential knowledge of the Nanjing Yunjin production process is predominantly stored in text format. As a highly specialized and vertical domain, this information is not readily convert into usable data. Previous studies on a knowledge graph-based Nanjing Yunjin Question-Answering System have partially addressed this issue. However, knowledge graphs need to be constantly updated and rely on predefined entities and relationship types. Faced with ambiguous or complex natural language problems, knowledge graph information retrieval faces some challenges. Therefore, this study proposes a Nanjing Yunjin Question-Answering System that integrates Knowledge Graphs and Retrieval Augmented Generation techniques. In this system, the ROBERTA model is first utilized to vectorize Nanjing Yunjin textual information, delving deep into textual semantics to unveil its profound cultural connotations. Additionally, the FAISS vector database is employed for efficient storage and retrieval of Nanjing Yunjin information, achieving a deep semantic match between questions and answers. Ultimately, related retrieval results are fed into the Large Language Model for enhanced generation, aiming for more accurate text generation outcomes and improving the interpretability and logic of the Question-Answering System. This research merges technologies like text embedding, vectorized retrieval, and natural language generation, aiming to overcome the limitations of knowledge graphs-based Question-Answering System in terms of graph updating, dependency on predefined types, and semantic understanding. System implementation and testing have shown that the Nanjing Yunjin Intelligent Question-Answering System, constructed on the basis of Knowledge Graphs and Retrieval Augmented Generation, possesses a broader knowledge base that considers context, resolving issues of polysemy, vague language, and sentence ambiguity, and efficiently and accurately generates answers to natural language queries. This significantly facilitates the retrieval and utilization of Yunjin knowledge, providing a paradigm for constructing Question-Answering System for other intangible cultural heritages, and holds substantial theoretical and practical significance for the deep exploration and discovery of the knowledge structure of human intangible heritage, promoting cultural inheritance and protection. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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25. Oral arsenic plus imatinib versus imatinib solely for newly diagnosed chronic myeloid leukemia: a randomized phase 3 trial with 5-year outcomes.
- Author
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Tian, Jie, Song, Yong-Ping, Zhang, Gao-Chong, Wang, Shu-Fang, Chu, Xiao-Xiang, Chai, Ye, Wang, Chun-Ling, He, Ai-Li, Zhang, Feng, Shen, Xu-Liang, Zhang, Wei-Hua, Yang, Lin-Hua, Nie, Da-Nian, Wang, Dong-Mei, Zhu, Huan-Ling, Gao, Da, Lou, Shi-Feng, Zhou, Ze-Ping, Su, Guo-Hong, and Li, Yan
- Abstract
Purpose: The synergistic effects of combining arsenic compounds with imatinib against chronic myeloid leukemia (CML) have been established using in vitro data. We conducted a clinical trial to compare the efficacy of the arsenic realgar–indigo naturalis formula (RIF) plus imatinib with that of imatinib monotherapy in patients with newly diagnosed chronic phase CML (CP-CML). Methods: In this multicenter, randomized, double-blind, phase 3 trial, 191 outpatients with newly diagnosed CP-CML were randomly assigned to receive oral RIF plus imatinib (n = 96) or placebo plus imatinib (n = 95). The primary end point was the major molecular response (MMR) at 6 months. Secondary end points include molecular response 4 (MR
4 ), molecular response 4.5 (MR4.5 ), progression-free survival (PFS), overall survival (OS), and adverse events. Results: The median follow-up duration was 51 months. Due to the COVID-19 pandemic, the recruitment to this study had to be terminated early, on May 28, 2020. The rates of MMR had no significant statistical difference between combination and imatinib arms at 6 months and any other time during the trial. MR4 rates were similar in both arms. However, the 12-month cumulative rates of MR4.5 in the combination and imatinib arms were 20.8% and 10.5%, respectively (p = 0.043). In core treatment since the 2-year analysis, the frequency of MR4.5 was 55.6% in the combination arm and 38.6% in the imatinib arm (p = 0.063). PFS and OS were similar at five years. The safety profiles were similar and serious adverse events were uncommon in both groups. Conclusion: The results of imatinib plus RIF as a first-line treatment of CP-CML compared with imatinib might be more effective for achieving a deeper molecular response (Chinadrugtrials number, CTR20170221). [ABSTRACT FROM AUTHOR]- Published
- 2024
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26. The remediation of polycyclic aromatic hydrocarbon contaminated soil by immobilized microorganisms using distiller's grains.
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Feng, Bo, Mao, Zhen, Yu, Jinbiao, Wang, Yuqian, Zhang, Zheyu, Xu, Liang, and Lu, Dongqiang
- Subjects
DISTILLERY by-products ,POLYCYCLIC aromatic hydrocarbons ,SOIL microbiology ,PERSISTENT pollutants ,SOIL degradation - Abstract
Polycyclic aromatic hydrocarbons are a persistent organic pollutant, and their biodegradation in the soil is often limited due to the limited degradation ability of indigenous bacteria and the low activity of exogenous PAH degrading bacteria. Immobilized microbial technology can protect microorganisms from the impact of harsh environments, and distiller's grains have the potential as carriers for microbial immobilization. This study aims to use distiller's grains as a microbial carrier, investigate the feasibility of immobilized microorganisms using distiller's grains for remediation of PAH contaminated soil; explore the relationship between soil nutrient content, consumption, and PAH degradation rate; and reveal the mechanism of bioremediation from the perspective of soil enzyme activity and microbial community composition. The results showed that after 72 days of remediation, the removal rates of phenanthrene and pyrene in the treatment of immobilized microorganisms in distiller grains reached 91.78% and 58.59%, respectively. Distiller grains can serve as a carrier for microorganisms, providing them with shelter and nutrients to enhance their chance of survival. Additionally, they can regulate the composition of soil particles and improve aeration, thereby increasing the efficiency of PAH degradation in soil. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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27. A von-Neumann-like photonic processor and its application in studying quantum signature of chaos.
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Yu, Shang, Liu, Wei, Tao, Si-Jing, Li, Zhi-Peng, Wang, Yi-Tao, Zhong, Zhi-Peng, Patel, Raj B., Meng, Yu, Yang, Yuan-Ze, Wang, Zhao-An, Guo, Nai-Jie, Zeng, Xiao-Dong, Chen, Zhe, Xu, Liang, Zhang, Ning, Liu, Xiao, Yang, Mu, Zhang, Wen-Hao, Zhou, Zong-Quan, and Xu, Jin-Shi
- Published
- 2024
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28. Microphysical properties of atmospheric soot and organic particles: measurements, modeling, and impacts.
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Li, Weijun, Riemer, Nicole, Xu, Liang, Wang, Yuanyuan, Adachi, Kouji, Shi, Zongbo, Zhang, Daizhou, Zheng, Zhonghua, and Laskin, Alexander
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SOOT ,CARBONACEOUS aerosols ,CLOUD condensation nuclei ,ICE nuclei ,BIOMASS burning ,WEATHER control ,RADIATIVE forcing - Abstract
Atmospheric soot and organic particles from fossil fuel combustion and biomass burning modify Earth's climate through their interactions with solar radiation and through modifications of cloud properties by acting as cloud condensation nuclei and ice nucleating particles. Recent advancements in understanding their individual properties and microscopic composition have led to heightened interest in their microphysical properties. This review article provides an overview of current advanced microscopic measurements and offers insights into future avenues for studying microphysical properties of these particles. To quantify soot morphology and ageing, fractal dimension (D
f ) is a commonly employed quantitative metric which allows to characterize morphologies of soot aggregates and their modifications in relation to ageing factors like internal mixing state, core-shell structures, phase, and composition heterogeneity. Models have been developed to incorporate Df and mixing diversity metrics of aged soot particles, enabling quantitative assessment of their optical absorption and radiative forcing effects. The microphysical properties of soot and organic particles are complex and they are influenced by particle sources, ageing process, and meteorological conditions. Furthermore, soluble organic particles exhibit diverse forms and can engage in liquid–liquid phase separation with sulfate and nitrate components. Primary carbonaceous particles such as tar balls and soot warrant further attention due to their strong light absorbing properties, presence of toxic organic constituents, and small size, which can impact human health. Future research needs include both atmospheric measurements and modeling approaches, focusing on changes in the mixing structures of soot and organic particle ensembles, their effects on climate dynamics and human health. [ABSTRACT FROM AUTHOR]- Published
- 2024
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29. Research on WSN reliable ranging and positioning algorithm for forest environment.
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Wu, Peng, Yu, Le, Yi, Xiaomei, Xu, Liang, Liu, LiJuan, Yi, YuTong, Jiang, Tengteng, and Tao, Chunling
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WIRELESS sensor networks ,ALGORITHMS - Abstract
Wireless sensor network (WSN) location is a significant research area. In complex environments like forests, inaccurate signal intensity ranging is a major challenge. To address this issue, this paper presents a reliable WSN distance measurement-positioning algorithm for forest environments. The algorithm divides the positioning area into several sub-regions based on the discrete coefficient of the collected signal strength. Then, using the fitting method based on the signal intensity value of each sub-region, the algorithm derives the reference points of the logarithmic distance path loss model and path loss index. Finally, the algorithm locates target nodes using anchor nodes in different regions. Additionally, to enhance the positioning accuracy, weight values are assigned to the positioning result based on the discrete coefficient of the signal intensity in each sub-region. Experimental results demonstrate that the proposed WSN algorithm has high precision in forest environments. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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30. Functionalized conjugated microporous polymer nanowires with a high photocatalytic degradation activity toward organic dyes.
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Zang, Yu, Chen, Yanlin, Yu, Yangyang, Fan, Minyi, Wang, Jianjun, Liu, Jiao, Xu, Liang, Jia, Hongge, Dong, Shaobo, and Miao, Fengjuan
- Subjects
PHOTODEGRADATION ,ORGANIC dyes ,PHOTOCATALYSTS ,NANOWIRES ,CONJUGATED polymers ,BAND gaps - Abstract
Functionalized conjugated microporous polymers (CMPs) containing amino, imino, and hydrazine groups are synthesized by the Sonogashira–Hagihara coupling reaction. Notably, the porosities, thermal stabilities, and morphologies of the CMPs can be controlled by the introduction of functional groups. Here, the relationships between the functional groups and photocatalytic performance are discussed for the first time. The CMP nanowires exhibit excellent photocatalytic performance in organic pollutant degradation: the degradation rate obtained by CMP-I3 bearing naphthalene groups via an imine bond is > 99.99%, and ~ 99.71% of the degradation activity is maintained after five cycles. Notably, the excellent photocatalytic properties of CMP-I3 are imparted by the introduction of the naphthalene groups, which reduced the band gap. The improved charge-transfer activity accounts for the highest and lowest photocurrent intensity and resistance achieved, respectively. Furthermore, the photocatalytic mechanism of CMPs reveals that the superoxide anion is the main active substance in the photocatalytic degradation of dyes. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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31. NLCECA score: a serum inflammatory-tumor biomarker score to predict survival of advanced perihilar cholangiocarcinoma after hepatic arterial infusion chemotherapy.
- Author
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Fu, Shjie, Li, Jie, Fan, Hua, Zheng, Kanglian, Leng, Boyu, Cao, Guang, Xu, Liang, Zhong, Yujie, Niu, Chuanxin, and Wang, Xiaodong
- Subjects
CHOLANGIOCARCINOMA ,NEUTROPHIL lymphocyte ratio ,RECEIVER operating characteristic curves ,CARCINOEMBRYONIC antigen ,BIOMARKERS - Abstract
Prognostic features in advanced perihilar cholangiocarcinoma (pCCA) patients who received first-line hepatic arterial infusion chemotherapy (HAIC) are unknown. The purpose of our study was to develop an applicable score based on serum inflammatory-tumor biomarkers to predict the survival of advanced pCCA patients who received first-line HAIC. In total, 106 advanced pCCA patients were enrolled as the training cohort. The optimal cutoff values of baseline variables were defined by the receiver operating characteristic method or according to previous publications. According to the results of Cox regression analysis, baseline neutrophil-to-lymphocyte ratio (NLR) > 3.19, carcinoembryonic antigen (CEA) > 10 ng/mL, and carbohydrate antigen 19-9 (CA19-9) > 200 U/mL were identified as independent survival predictors, which were used to develop the NLCECA score (NLR, CEA, and CA19-9). When including the NLCECA score in the multivariate analysis, the NLCECA score was the only independent predictor of survival. The risk of survival decreased by 111.9% for each 1-point increase in the NLCECA score. Additionally, the NLCECA score could also predict survival in another 33 patients in the validation cohort (P < 0.001). In summary, the NLCECA score is a potential biomarker system for predicting the survival of advanced pCCA patients who received first-line HAIC. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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- View/download PDF
32. Sonocatalytic degradation of tetracycline by BiVO4/CuWO4 nanocomposites: operational parameters, sonocatalytic mechanism, and degradation pathways.
- Author
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An, Hui-Li, Wang, Xin, Ju, Wan-Ting, Ge, Ying-Di, Zhou, Xin-Yi, Wang, Yang, Zhang, Lin, Xu, Liang, and Wang, Xiao-Fang
- Subjects
TETRACYCLINE ,TETRACYCLINES ,NANOCOMPOSITE materials ,WASTEWATER treatment ,FREE radicals - Abstract
In this study, BiVO
4 /CuWO4 nanocomposites with S-scheme heterojunction structure were prepared firstly and the properties were analyzed by various techniques. The sonocatalytic activity was evaluated by the degradation of tetracycline (TET). Under the optimum experimental conditions of initial concentration of TET = 25 mg/L, composite ratio of BiVO4 and CuWO4 = 15%, catalyst addition = 1 g/L, ultrasonic time = 120 min, ultrasonic power = 500 W, pH = 7, the experiment results showed that BiVO4 /CuWO4 sonocatalyst removed TET by 81.05 ± 2.92%. K2 S2 O8 was verified to enhance the sonocatalytic performance of BiVO4 /CuWO4 efficiently, and the removal ratio of TET could reach 91.25 ± 1.95% within 120 min by using BiVO4 /CuWO4 and K2 S2 O8 . The free radical (ROS) quenching experiment and TA-PL technology proved that the main free radical of degradation was ·OH. The potential sonocatalytic mechanism showed that the enhanced catalytic efficiency was due to the construction of S-scheme heterojunctions, which improved electron–hole pair (e− –h+ ) separation efficiency and rapid kinetics. The speculated TET degradation route of TET included intermediate products was proposed and four reused experiments proved that BiVO4 /CuWO4 had good recyclability. In conclusion, the prepared BiVO4 /CuWO4 composites with S-type heterojunction mechanism have more possibilities in wastewater treatment, which provides a helpful guide for the synthesis and application of composite sonocatalysts. [ABSTRACT FROM AUTHOR]- Published
- 2024
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33. Synthesis of robust and transparent poly(butenyl sorbate) membrane for separation of carbon dioxide/methane.
- Author
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Xu, Liang, Zang, Yu, Wang, Yanqiu, Narumi, Atsushi, Sato, Shin-ichiro, Shen, Xiande, and Kakuchi, Toyoji
- Subjects
- *
MEMBRANE separation , *CARBON dioxide , *MOLECULAR weights , *AMINO group , *DITHIOLS , *METHANE , *ION-permeable membranes , *THIOLS , *DIELECTROPHORESIS - Abstract
In this study, the preparation of robust and transparent poly(butenyl sorbate) (PBS) membranes (PBS-R) was studied in terms of their CO2/CH4 separation performance. The organocatalytic group transfer polymerization of butenyl sorbate was used for the synthesis of PBS with a designed molecular weight and a moderate molecular weight distribution. For the first time, facile fabrication of PBS-R was achieved through thiol-ene addition between the butenyl groups of PBS and dithiols under 365-nm ultraviolet irradiation. The mechanical properties and CO2/CH4 separation performance of the PBS-R membranes were controlled by introducing an amino-triazole functional group and regulating the length and bulkiness of the dithiol spacers during thiol-ene addition. The amino and triazole groups of the PBS-R membrane showed high affinity to CO2, thereby increasing the CO2/CH4 permselectivity from 9.18 to 10.8 and the CO2 permeability from 127 to 142 barrer. The effect of tensile strength on CO2 permeability was evaluated by preparing PBS-R membranes using dithiols with two rigid benzene rings as spacers and flexible spacers. In addition, the effect of the spacer structure on the permselectivity of PBS-R was investigated using 1,4-butanedithiol, 2,2′-oxydiethanethiol, 1,8-octanedithiol, 1,4-benzenedithiol, and 4,4′-thiobisbenzenethiol. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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34. Dynamic Circular Network-Based Federated Dual-View Learning for Multivariate Time Series Anomaly Detection.
- Author
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Zhang, Weishan, Wang, Yuqian, Chen, Leiming, Yuan, Yong, Zeng, Xingjie, Xu, Liang, and Zhao, Hongwei
- Abstract
Multivariate time-series data exhibit intricate correlations in both temporal and spatial dimensions. However, existing network architectures often overlook dependencies in the spatial dimension and struggle to strike a balance between long-term and short-term patterns when extracting features from the data. Furthermore, industries within the business community are hesitant to share their raw data, which hinders anomaly prediction accuracy and detection performance. To address these challenges, the authors propose a dynamic circular network-based federated dual-view learning approach. Experimental results from four open-source datasets demonstrate that the method outperforms existing methods in terms of accuracy, recall, and F1_score for anomaly detection. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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- View/download PDF
35. LOXL1 promotes tumor cell malignancy and restricts CD8 + T cell infiltration in colorectal cancer.
- Author
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Li, Chenxi, Chen, Siqi, Fang, Xiaona, Du, Yaqing, Guan, Xin-Yuan, Lin, Runhua, Xu, Liang, Lan, Ping, and Yan, Qian
- Abstract
Background: Colorectal cancer (CRC) is a leading cause of cancer mortality globally. Lymph node metastasis and immunosuppression are main factors of poor prognosis in CRC patients. Lysyl oxidase like 1 (LOXL1), part of the lysyl oxidase (LOX) family, plays a yet unclear role in CRC. This study aimed to identify effective biomarkers predictive of prognosis and efficacy of immunotherapy in CRC patients, and to elucidate the prognostic value, clinical relevance, functional and molecular features, and immunotherapy predictive role of LOXL1 in CRC and pan-cancer. Methods: Weighted gene co-expression network analysis (WGCNA) was employed to explore gene modules related to tumor metastasis and CD8 + T cell infiltration. LOXL1 emerged as a hub gene through differential gene expression and survival analysis. The molecular signatures, functional roles, and immunological characteristics affected by LOXL1 were analyzed in multiple CRC cohorts, cell lines and clinical specimens. Additionally, LOXL1's potential as an immunotherapy response indicator was assessed, along with its role in pan-cancer. Results: Turquoise module in WGCNA analysis was identified as the hub module associated with lymph node metastasis and CD8 + T cell infiltration. Aberrant elevated LOXL1 expression was observed in CRC and correlated with poorer differentiation status and prognosis. Molecular and immunological characterization found that LOXL1 might mediate epithelial-mesenchymal transition (EMT) process and immunosuppressive phenotypes of CRC. Functional study found that LOXL1 enhanced tumor cell proliferation, migration and invasion. Moreover, high LOXL1 levels corresponded to reduced CD8 + T cell infiltration and predicted poor clinical outcomes of immunotherapy. Similar trends were also observed at the pan-cancer level. Conclusions: Our findings underscore the critical role of LOXL1 in modulating both malignancy and immunosuppression in CRC. This positions LOXL1 as a promising biomarker for predicting prognosis and the response to immunotherapy in CRC patients. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
36. A novel bifunctional metalloporphyrin-based hyper-crosslinked ionic polymer as heterogeneous catalyst for efficiently converting CO2 into cyclic carbonates.
- Author
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Wang, Jianjun, Chen, Jiaqi, Li, Dongning, Liu, Jiao, Shi, Zhichun, Xu, Liang, and Zang, Yu
- Subjects
CONDUCTING polymers ,HETEROGENEOUS catalysts ,COOPERATIVE binding (Biochemistry) ,TURNOVER frequency (Catalysis) ,METALLOPORPHYRINS ,CARBONATES ,POLYELECTROLYTES - Abstract
The rapid development of industrialization generated an urgent requirement for the catalytic conversion of CO
2 into high-value-added chemical products. Herein, a class of novel bifunctional metalloporphyrin-based hyper-crosslinked ionic polymer (ImHCP-Co) was synthesized via one-pot Friedel–Crafts alkylation and quaternization reactions. The obtained bifunctional ImHCP-Co showed a high BET surface area and sufficient CO2 adsorption capacity. Relying on the synergistic effect of the electrophilic and nucleophilic functionalities, the as-prepared ImHCP-Co showed an excellent performance in CO2 cycloaddition using epichlorohydrin as the substrate (99% conversion and 99% selectivity) and can be carried out without any solvents or cocatalysts to afford a high turnover number. Importantly, it could also convert various epoxide substrates into the corresponding cyclic carbonates and can maintain 82.5% of its catalytic ability after 5 cycles. The catalytic mechanism was systematically explained by DFT calculation and proved the cooperative effect of Co2+ centers and nucleophilic Cl− in the catalytic process. This study provides a new avenue for the design and preparation of HCP-based multifunctional catalysts used for the treatment of greenhouse gases. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
37. Suppressing MTERF3 inhibits proliferation of human hepatocellular carcinoma via ROS-mediated p38 MAPK activation.
- Author
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Zheng, Zhihai, Zhao, Youjuan, Yu, Hongjia, Wang, Tingting, Li, Jinhai, Xu, Liang, Ding, Chunming, He, Lan, Wu, Lijun, and Dong, Zhixiong
- Subjects
HEPATOCELLULAR carcinoma ,MITOGEN-activated protein kinases ,CELL cycle ,MITOCHONDRIAL DNA ,INHIBITION of cellular proliferation - Abstract
Mitochondrial transcription termination factor 3 (MTERF3) negatively regulates mitochondrial DNA transcription. However, its role in hepatocellular carcinoma (HCC) progression remains elusive. Here, we investigate the expression and function of MTERF3 in HCC. MTERF3 is overexpressed in HCC tumor tissues and higher expression of MTERF3 positively correlates with poor overall survival of HCC patients. Knockdown of MTERF3 induces mitochondrial dysfunction, S-G2/M cell cycle arrest and apoptosis, resulting in cell proliferation inhibition. In contrast, overexpression of MTERF3 promotes cell cycle progression and cell proliferation. Mechanistically, mitochondrial dysfunction induced by MTERF3 knockdown promotes ROS accumulation, activating p38 MAPK signaling pathway to suppress HCC cell proliferation. In conclusion, ROS accumulation induced by MTERF3 knockdown inhibits HCC cell proliferation via p38 MAPK signaling pathway suggesting a promising target in HCC patients. Targeting mitochondrial transcription termination factor MTERF3 induces mitochondrial dysfunction and inhibits the proliferation via activating ROS-dependent p38 MAPK pathway in hepatocellular carcinoma. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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- View/download PDF
38. Economic Optimization Operation Approach of Integrated Energy System Considering Wind Power Consumption and Flexible Load Regulation.
- Author
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Meng, Qinglin, Xu, Jing, Ge, Leijiao, Wang, Zhongguan, Wang, Jianxiao, Xu, Liang, and Tang, Zhipeng
- Published
- 2024
- Full Text
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39. Integrative transcriptomic and metabolomic analyses reveal the phenylpropanoid and flavonoid biosynthesis of Prunus mume.
- Author
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Wu, Rui, Qian, Chengcheng, Yang, Yatian, Liu, Yi, Xu, Liang, Zhang, Wei, and Ou, Jinmei
- Subjects
PHENYLPROPANOIDS ,FLAVONOIDS ,BIOSYNTHESIS ,METABOLOMICS ,ORNAMENTAL plants ,PRUNUS ,FLAVONOLS - Abstract
Prunus mume is an important medicinal plant with ornamental and edible value. Its flowers contain phenylpropanoids, flavonoids and other active components, that have important medicinal and edible value, yet their molecular regulatory mechanisms in P. mume remain unclear. In this study, the content of total flavonoid and total phenylpropanoid of P. mume at different developmental periods was measured first, and the results showed that the content of total flavonoid and total phenylpropanoid gradually decreased in three developmental periods. Then, an integrated analysis of transcriptome and metabolome was conducted on three developmental periods of P. mume to investigate the law of synthetic accumulation for P. mume metabolites, and the key enzyme genes for the biosynthesis of phenylpropanoids and flavonoids were screened out according to the differentially expressed genes (DEGs). A total of 14,332 DEGs and 38 differentially accumulate metabolites (DAMs) were obtained by transcriptomics and metabolomics analysis. The key enzyme genes and metabolites in the bud (HL) were significantly different from those in the half-opening (BK) and full-opening (QK) periods. In the phenylpropanoid and flavonoid biosynthesis pathway, the ion abundance of chlorogenic acid, naringenin, kaempferol, isoquercitrin, rutin and other metabolites decreased with the development of flowers, while the ion abundance of cinnamic acid increased. Key enzyme genes such as HCT, CCR, COMT, CHS, F3H, and FLS positively regulate the downstream metabolites, while PAL, C4H, and 4CL negatively regulate the downstream metabolites. Moreover, the key genes FLS (CL4312-2, CL4312-3, CL4312-4, CL4312-5, CL4312-6) regulating the synthesis of flavonols are highly expressed in bud samples. The dynamic changes of these metabolites were validated by determining the content of 14 phenylpropanoids and flavonoids in P. mume at different developmental periods, and the transcription expression levels of these genes were validated by real-time PCR. Our study provides new insights into the molecular mechanism of phenylpropanoid and flavonoid accumulation in P. mume. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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- View/download PDF
40. A natural Nrf2 activator glucoraphanin improves hepatic steatosis in high-fat diet-induced obese male mice associated with AMPK activation.
- Author
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Promsuwan, Suratsawadee, Sawamoto, Kazuki, Xu, Liang, Nagashimada, Mayumi, Nagata, Naoto, and Takiyama, Yumi
- Abstract
Genetic and pharmacological activation of the transcription factor nuclear factor, erythroid derived 2, like 2 (Nrf2) alleviates high-fat diet (HFD)-induced obesity in mice; however, synthetic Nrf2 activators are not clinically available due to safety concerns. Dietary glucoraphanin (GR), a naturally occurring compound found in cruciferous vegetables that activates Nrf2 and induces its target antioxidant genes. We previously demonstrated that GR increased thermogenesis and mitigated HFD-induced obesity in lean healthy mice. In this study, we investigated the therapeutic effects of GR on pre-existing obesity and associated metabolic disorders, such as hepatic steatosis, with or without low-fat dietary intervention. Eight-week-old male C57BL/6J mice were fed an HFD for 9 weeks to induce obesity. Subsequently, these obese mice were fed either the HFD or a normal chow diet, supplemented with or without GR, for an additional 11 weeks. GR supplementation did not decrease the body weight of HFD-fed mice; however, it significantly reduced plasma alanine aminotransferase and aspartate aminotransferase levels and hepatic triglyceride accumulation. These improvements in liver damage by GR were associated with decreased expression levels of fatty acid synthesis genes and proinflammatory chemokine genes, suppressed c-Jun N-terminal kinase activation, and reduced proinflammatory phenotypes of macrophages in the liver. Moreover, metabolome analysis identified increased hepatic levels of adenosine 5′-monophosphate (AMP) in HFD-GR mice compared with those in HFD mice, which agreed with increased phosphorylation levels of AMP-activated protein kinase. Our results show that GR may have a therapeutic potential for treating obesity-associated hepatic steatosis. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
41. Analysis of light propagation characteristic in the aero-optic flow field of cone-headed vehicle with side window.
- Author
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Xu, Liang, Zhou, Liye, Wang, Luyang, Zhao, Shiwei, and Wang, Tao
- Abstract
Aero-optic imaging deviation research is carried out for infrared-guided vehicle with cone-head side window, with a focus on the propagation characteristics of light in an aero-optic flow field. When the light entering the aero-optic flow field from the free-stream should be close to the normal, numerous data indicate that the light is refracted away from the normal. This paper divides the aero-optic flow field into two parts and uses the gas density distribution in the aero-optic flow field to propose the hypothesis that there are two modes of refraction when light propagates through the flow field. The results show that light propagates from the optically denser medium to the optically thinner medium after passing through the shock wave and eventually leads to refraction away from the normal when the light enters the aero-optic flow field. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
42. Geometric constraint-triggered collagen expression mediates bacterial-host adhesion.
- Author
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Feng, Yuting, Wang, Shuyi, Liu, Xiaoye, Han, Yiming, Xu, Hongwei, Duan, Xiaocen, Xie, Wenyue, Tian, Zhuoling, Yuan, Zuoying, Wan, Zhuo, Xu, Liang, Qin, Siying, He, Kangmin, and Huang, Jianyong
- Subjects
GENE expression ,BACTERIAL adhesion ,COLLAGEN ,ANIMAL experimentation ,RNA sequencing - Abstract
Cells living in geometrically confined microenvironments are ubiquitous in various physiological processes, e.g., wound closure. However, it remains unclear whether and how spatially geometric constraints on host cells regulate bacteria-host interactions. Here, we reveal that interactions between bacteria and spatially constrained cell monolayers exhibit strong spatial heterogeneity, and that bacteria tend to adhere to these cells near the outer edges of confined monolayers. The bacterial adhesion force near the edges of the micropatterned monolayers is up to 75 nN, which is ~3 times higher than that at the centers, depending on the underlying substrate rigidities. Single-cell RNA sequencing experiments indicate that spatially heterogeneous expression of collagen IV with significant edge effects is responsible for the location-dependent bacterial adhesion. Finally, we show that collagen IV inhibitors can potentially be utilized as adjuvants to reduce bacterial adhesion and thus markedly enhance the efficacy of antibiotics, as demonstrated in animal experiments. Cells in the body live in geometrically constrained microenvironments. Here, Feng at al report that these constraints induce collagen IV expression which is responsible for location dependent bacterial adhesion. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
43. Lightweight target speaker separation network based on joint training.
- Author
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Wang, Jing, Liu, Hanyue, Xu, Liang, Yang, Wenjing, Yi, Weiming, and Liu, Fang
- Subjects
COMPUTATIONAL linguistics ,SPEECH ,SPEECH processing systems ,PROBLEM solving - Abstract
Target speaker separation aims to separate the speech components of the target speaker from mixed speech and remove extraneous components such as noise. In recent years, deep learning-based speech separation methods have made significant breakthroughs and have gradually become mainstream. However, these existing methods generally face problems with system latency and performance upper limits due to the large model size. To solve these problems, this paper proposes improvements in the network structure and training methods to enhance the model's performance. A lightweight target speaker separation network based on long-short-term memory (LSTM) is proposed, which can reduce the model size and computational delay while maintaining the separation performance. Based on this, a target speaker separation method based on joint training is proposed to achieve the overall training and optimization of the target speaker separation system. Joint loss functions based on speaker registration and speaker separation are proposed for joint training of the network to further improve the system's performance. The experimental results show that the lightweight target speaker separation network proposed in this paper has better performance while being lightweight, and joint training of the target speaker separation network with our proposed loss function can further improve the separation performance of the original model. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
44. An experimental study on the impact behavior of cavitation inside tip clearance of a hydrofoil.
- Author
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Cao, Yan-tao, Xu, Liang-hao, and Peng, Xiao-xing
- Abstract
Tip clearance cavitation is one of the most common cavitation phenomena exist on duct propellers, pumps and some hydraulic turbines, which may lead to erosion of the components. Due to the influence of the nearby wall, cavitation inside the tip clearance is more complicated than other cases without interaction. So far, the understanding about the impact mechanism of tip clearance cavitation is still limited. In this paper, to obtain the impact behavior of tip clearance cavitation, a high-speed camera was used to capture the cavitation behavior inside the tip clearance of a hydrofoil, and surface paint coating peeling method was applied to show the impact region. Results indicated that cavitation around the tip of the hydrofoil was composed of a tip separation cavity and a tip leakage vortex cavity, and the one with contribution to impact was the tip separation cavity. Through the comprehensive analysis of the paint peeling region and dynamic behavior of tip separation cavity, the impact was found to be related to the local collapse and rebound of the cloud cavitation shed from the attached part. In addition, the influence of tip clearance size on the behavior of tip clearance cavitation was also investigated. As the tip clearance size increased, the tip separation cavity tended to transfer from sheet cavitation to vortex cavitation. These findings can provide a sound basis for evaluating the erosion risk arising from the tip clearance cavitation. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
45. An efficient extended IHB method for non-linear dynamic analysis with multi-frequency harmonic excitations using an auto adapted truncation technique.
- Author
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Hui, Yi, Xie, Peiyu, Ruan, Qipan, Zhu, Weidong, and Xu, Liang
- Subjects
NONLINEAR analysis ,RUNGE-Kutta formulas ,NONLINEAR systems - Abstract
Demand on the analysis of a nonlinear system under multi-frequency harmonic excitations is commonly encountered in an engineering field, which requires a feasible analysis technique. The existing incremental harmonic balance method, however, shows an apparent deficiency in the calculation efficiency, due to the inappropriate rule of selecting frequency components of solutions. A highly efficient extended incremental harmonic balance extended IHB method is developed to tackle this problem. Firstly, multiple time scales are introduced to express the solutions. Secondly, through detailed examination of the response Fourier spectrum, an auto adapted truncation technique of Fourier series is developed for selection of necessary harmonic terms of solutions. The adopted harmonic terms vary in every round of solution tracing, according to the amplitudes of the harmonic terms of interest. The feasibility of the proposed method is illustrated through three different examples. The accuracy of the method is verified by comparing the obtained results with that those from the Runge–Kutta method. The efficiency of the proposed algorithm is compared with that of the algorithm of the Pusenjak–Oblak method. It is shown that the proposed method can dramatically reduce the number of harmonic terms, as it only needs a maximum of one-fifth of harmonic terms of the existing method. Such results suggest that the proposed method has a strong advantage in the calculation efficiency for analyzing a nonlinear system under multi-frequency harmonic excitations. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
46. Experimental 3D super-localization with Laguerre–Gaussian modes.
- Author
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Hu, Chenyu, Xu, Liang, Wang, Ben, Li, Zhiwen, Zhang, Yipeng, Zhang, Yong, and Zhang, Lijian
- Subjects
- *
MAXIMUM likelihood statistics , *THREE-dimensional imaging , *INFORMATION retrieval , *COMPUTER algorithms , *MICROSCOPY - Abstract
Improving three-dimensional (3D) localization precision is of paramount importance for super-resolution imaging. By properly engineering the point spread function (PSF), such as utilizing Laguerre–Gaussian (LG) modes and their superposition, the ultimate limits of 3D localization precision can be enhanced. However, achieving these limits is challenging, as it often involves complicated detection strategies and practical limitations. In this work, we rigorously derive the ultimate 3D localization limits of LG modes and their superposition, specifically rotation modes, in the multi-parameter estimation framework. Our findings reveal that a significant portion of the information required for achieving 3D super-localization of LG modes can be obtained through feasible intensity detection. Moreover, the 3D ultimate precision can be achieved when the azimuthal index l is zero. To provide a proof-of-principle demonstration, we develop an iterative maximum likelihood estimation (MLE) algorithm that converges to the 3D position of a point source, considering the pixelation and detector noise. The experimental implementation exhibits an improvement of up to two-fold in lateral localization precision and up to twenty-fold in axial localization precision when using LG modes compared to Gaussian mode. We also showcase the superior axial localization capability of the rotation mode within the near-focus region, effectively overcoming the limitations encountered by single LG modes. Notably, in the presence of realistic aberration, the algorithm robustly achieves the Cramér-Rao lower bound. Our findings provide valuable insights for evaluating and optimizing the achievable 3D localization precision, which will facilitate the advancements in super-resolution microscopy. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
47. An Improved Time-Domain Inverse Technique for Localization and Quantification of Rotating Sound Sources.
- Author
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Zhang, Xiaozheng, Li, Yinlong, Zhang, Yongbin, Bi, Chuanxing, Li, Jinghao, and Xu, Liang
- Abstract
The time-domain inverse technique based on the time-domain rotating equivalent source method has been proposed to localize and quantify rotating sound sources. However, this technique encounters two problems to be addressed: one is the time-consuming process of solving the transcendental equation at each time step, and the other is the difficulty of controlling the instability problem due to the time-varying transfer matrix. In view of that, an improved technique is proposed in this paper to resolve these two problems. In the improved technique, a de-Dopplerization method in the time-domain rotating reference frame is first applied to eliminate the Doppler effect caused by the source rotation in the measured pressure signals, and then the restored pressure signals without the Doppler effect are used as the inputs of the time-domain stationary equivalent source method to locate and quantify sound sources. Compared with the original technique, the improved technique can avoid solving the transcendental equation at each time step, and facilitate the treatment of the instability problem because the transfer matrix does not change with time. Numerical simulation and experimental results show that the improved technique can eliminate the Doppler effect effectively, and then localize and quantify the rotating nonstationary or broadband sources accurately. The results also demonstrate that the improved technique can guarantee a more stable reconstruction and compute more efficiently than the original one. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
48. In situ imaging of the atomic phase transition dynamics in metal halide perovskites.
- Author
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Ma, Mengmeng, Zhang, Xuliang, Chen, Xiao, Xiong, Hao, Xu, Liang, Cheng, Tao, Yuan, Jianyu, Wei, Fei, and Shen, Boyuan
- Subjects
PHASE transitions ,METAL halides ,ATOMIC transitions ,PEROVSKITE ,TRANSITION metals ,ELECTRON microscopy - Abstract
Phase transition dynamics are an important concern in the wide applications of metal halide perovskites, which fundamentally determine the optoelectronic properties and stabilities of perovskite materials and devices. However, a more in-depth understanding of such a phase transition process with real atomic resolution is still limited by the immature low-dose electron microscopy and in situ imaging studies to date. Here, we apply an emergent low-dose imaging technique to identify different phase structures (α, β and γ) in CsPbI
3 nanocrystals during an in-situ heating process. The rotation angles of PbI6 octahedrons can be measured in these images to quantitatively describe the thermal-induced phase distribution and phase transition. Then, the dynamics of such a phase transition are studied at a macro time scale by continuously imaging the phase distribution in a single nanocrystal. The structural evolution process of CsPbI3 nanocrystals at the particle level, including the changes in morphology and composition, is also visualized with increasing temperature. These results provide atomic insights into the transition dynamics of perovskite phases, indicating a long-time transition process with obvious intermediate states and spatial distribution that should be generally considered in the further study of structure-property relations and device performance. Phase transition dynamics are an important concern in the wide applications of metal halide perovskites. Here authors apply low-dose imaging technique to reveal the phase transition dynamics of CsPbI3 during in-situ heating process with atomic resolution. [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
49. Screening the optimal modified biochar for nitrogen retention in black soil.
- Author
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Wang, Yifan, Li, Dannan, Liu, Hechun, Wu, Di, Ai, Yunhe, Li, Jianen, Xu, Liang, Liu, Wei, Qu, Jianhua, Tao, Yue, Wang, Jing, Wang, Jianzhi, and Zhang, Ying
- Subjects
BLACK cotton soil ,BIOCHAR ,SOIL leaching ,NITROGEN ,NITROGEN in soils - Abstract
Reducing the environmental problems caused by nitrogen loss and nitrogen pollution is of great significance. The addition of biochar to soil is a new method for increasing nitrogen interception due to the special structural and physicochemical properties of biochar. The optimal modified biochar was screened out after acid–base modification and batch adsorption test in this paper. And then the effects of different soil and biochar mixing methods on soil physicochemical properties and nitrogen adsorption and retention were explored through soil column leaching test. The results showed that the biochar with a pyrolysis temperature of 700 °C had the best adsorption effect on nitrogen after being modified by 0.1 mol/L HCI, and the adsorption capacity of nitrate nitrogen reached 121.46 mg/g. The adsorption process of ammonia nitrogen and nitrate nitrogen conformed to the Langmuir model and was mainly homogeneous monolayer. After mixing the selected modified biochar with black soil, the pH increased by 4.77%, the content of ammonia nitrogen increased by 4.89%, and the nitrate content increased by 16.62%. In this study, the adsorption effect of biochar on nitrogen in black soil was discussed, so as to explore the optimal use of biochar in soil, which provided some reference basis for the relevant research. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
50. Construction and application of a knowledge graph-based question answering system for Nanjing Yunjin digital resources.
- Author
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Xu, Liang, Lu, Lu, and Liu, Minglu
- Subjects
- *
QUESTION answering systems , *MACHINE learning , *KNOWLEDGE graphs , *PROTECTION of cultural property , *DATABASES , *CULTURAL property , *REACTION time - Abstract
Nanjing Yunjin, one of China's traditional silk weaving techniques, is renowned for its unique local characteristics and exquisite craftsmanship, and was included in the Representative List of the Intangible Cultural Heritage of Humanity by UNESCO in 2009. However, with rapid development in weaving technology, ever-changing market demands, and shifting public aesthetics, Nanjing Yunjin, as an intangible cultural heritage, faces the challenge of survival and inheritance. Addressing this issue requires efficient storage, management, and utilization of Yunjin knowledge to enhance public understanding and recognition of Yunjin culture. In this study, we have constructed an intelligent question-answering system for Nanjing Yunjin digital resources based on knowledge graph, utilizing the Neo4j graph database for efficient organization, storage, and protection of Nanjing Yunjin knowledge, thereby revealing its profound cultural connotations. Furthermore, we adopted deep learning algorithms for natural language parsing. Specifically, we adopted BERT-based intent recognition technology to categorize user queries by intent, and we employed the BERT + BiGRU + CRF model for entity recognition. By comparing with BERT + BILSTM + CRF, BERT + CRF and BILSTM + CRF models, our model demonstrated superior performance in terms of precision, recall, and F1 score, substantiating the superiority and effectiveness of this model. Finally, based on the parsed results of the question, we constructed knowledge graph query statements, executed by the Cypher language, and the processed query results were fed back to the users in natural language. Through system implementation and testing, multiple indices including system response time, stability, load condition, accuracy, and scalability were evaluated. The experimental results indicated that the Nanjing Yunjin intelligent question-answering system, built on the knowledge graph, is able to efficiently and accurately generate answers to user's natural language queries, greatly facilitating the retrieval and utilization of Yunjin knowledge. This not only reinforces the transmission, promotion, and application of Yunjin culture but also provides a paradigm for constructing other intangible cultural heritage question-answering systems based on knowledge graphs. This has substantial theoretical and practical significance for deeply exploring and uncovering the knowledge structure of human intangible heritage, promoting cultural inheritance and protection. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
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