10 results on '"Jouda, Jean-Bosco"'
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2. Chemical constituents of the fruits of Gambeya lacourtiana (Sapotaceae).
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Talla, Rostan Mangoua, Jouda, Jean-Bosco, Mawabo, Isabelle Kamga, Tegasne, Catherine, Happi, Gervais Mouthé, Lenta, Bruno Ndjakou, Kapche, Gilbert Deccaux Wabo Fotso, Frese, Marcel, Wandji, Jean, and Sewald, Norbert
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• Isolation of 4 new compounds from the fruits of Gambeya lacourtiana (Sapotaceae). • First report of cerebrosides and ceramide in the genus Gambeya. • Moderate antibacterial activity of lacourtianoside II. • MS/MS fragmentation of compounds 1, 2 and 4 Phytochemical investigation of the fruits of Gambeya lacourtiana led to the isolation of four new compounds, lacourtianol (1) , lacourtianoside I (2) , lacourtianoside II (3) and lacourtianamide (4) together with six known compounds: 3- O -acetylbetulin (5) , 3- O -acetylerythrodiol (6) , β -amyrincaproate (7) , lupeolhexanoate (8) , erythrodiol 3- O -palmitate (9) , and D -mannitol (10). The structures of 1 - 10 were elucidated on the basis of 1D and 2D NMR spectroscopic data, mass spectrometry and by comparison of spectroscopic data with those from the literature. Compounds 1 - 10 were evaluated for their antibacterial activity. Lacourtianoside II (3) exhibited moderate activity against Salmonella typhi CHU, Staphylococcus aureus (ATCC 43300 and ATCC 25923) and Enterobacter cloacae k2 with the same MIC value of 22.3 μM. [ABSTRACT FROM AUTHOR]
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- 2020
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3. Two new indole alkaloids from Tabernaemontana contorta Stapf.
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Foudjo Melacheu, Gertrude Laura, Mfotie Njoya, Emmanuel, Jouda, Jean-Bosco, Wakeu Kweka, Brussine Nadege, Djama Mbazoa, Céline, Wang, Fei, and Wandji, Jean
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Graphical abstract Highlights • Plants of the genus Tabernaemontana mainly contain monoterpenoid indole alkaloids as well as triterpenoids. • This article reports the isolation of two new monoterpenoid indole alkaloids. • The compounds were isolated using usual chromatographic method and their structures elucidated using 1D and 2D NMR. Abstract Two new indole alkaloid derivatives, 5,6-dioxo-11-methoxy voacangine (1) and (-)-apparicin-21-one (2), together with four known compounds, voacangine (3), ursolic acid (4), 3-methoxyursolic acid (5) and asiatic acid (6) were isolated from the fruits of Tabernaemontana contorta Stapf (Apocynaceae). Their structures were determined using 1D and 2D NMR and HRESI-MS measurements. The new indole alkaloids were tested on lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells to determine their inhibitory effect on nitric oxide (NO) production, but did not have any significant inhibitory activity. Compound (1) slightly increased the proliferation of RAW 264.7 cells in relation with the increased level of NO released by these cells. [ABSTRACT FROM AUTHOR]
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- 2019
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4. Secondary metabolites from the stem bark of Stereospermum acuminatissimum and their antimicrobial activity.
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Leutcha, Peron Bosco, Jouda, Jean-Bosco, Tsague Tankeu, Virginie Flaure, Magnibou, Larissa Mekontso, Atia-tul-Wahab, Choudhry, Muhammad Iqbal, and Lannang, Alain Meli
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METABOLITES , *ANTI-infective agents , *SHIGELLA flexneri , *CINNAMIC acid , *ANTIBACTERIAL agents , *ETHYL acetate , *PHYTOCHEMICALS - Abstract
Phytochemical investigation of the stem bark of Stereospermum acuminatissimum resulted in the isolation of seventeen compounds, including four tirucallanes (1 – 4), three hopanes (5 – 7), one oleanane (8), three sterols (9 – 11), three saponins (12 – 14), two cinnamic acids (15 – 16), and one iridoid (17). The dehydration of compound 5 led to compound 5a. The structures of all compounds were elucidated by analysis of spectroscopic and mass spectrometric data. Compounds 1 , 6 and 7 are reported from the Bignoniaceae family for the first time, while compounds 11 – 14 and 16 are reported from S. acuminatissimum for the first time. The in vitro antibacterial activities of some compounds (1 – 5 , 8 , 5a), the crude extract and the ethyl acetate fraction were assessed. The crude extract showed significant antibacterial activity against Staphylococcus aureus , Salmonea pneumonia and Klebsiella pneumoniae with MIC values of 62 μg/mL. Compound 1 revealed moderate antibacterial activities against K. pneumoniae , Shigella flexneri and Methycillin resistant S. aureus with MIC values of 62, 62 and 31 μg/mL respectively. [Display omitted] • Phytochemical investigation of Stereospermum acuminatissimum K. Schum. • Dehydration of one of the isolated compound. • Chemophenetic significance of the isolated compounds. • Antibacterial activities of crude extract, fractions and compounds. [ABSTRACT FROM AUTHOR]
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- 2023
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5. Penialidins A–C with strong antibacterial activities from Penicillium sp., an endophytic fungus harboring leaves of Garcinia nobilis.
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Jouda, Jean-Bosco, Kusari, Souvik, Lamshöft, Marc, Mouafo Talontsi, Ferdinand, Douala Meli, Clovis, Wandji, Jean, and Spiteller, Michael
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ALTERNATIVE medicine , *ANTI-infective agents , *FUNGI , *LEAVES , *MEDICINAL plants , *MOLECULAR structure , *NUCLEAR magnetic resonance spectroscopy , *SPECTRUM analysis , *IN vitro studies , *PHARMACODYNAMICS - Abstract
Three new polyketides named penialidins A–C ( 1 – 3 ), along with one known compound, citromycetin ( 4 ), were isolated from an endophytic fungus, Penicillium sp., harbored in the leaves of the Cameroonian medicinal plant Garcinia nobilis . Their structures were elucidated by means of spectroscopic and spectrometric methods (NMR and HRMS n ). The antibacterial efficacies of the new compounds ( 1 – 3 ) were tested against the clinically-important risk group 2 (RG2) bacterial strains of Staphylococcus aureus and Escherichia coli . The ecologically imposing strains of E. coli (RG1), Bacillus subtilis and Acinetobacter sp. BD4 were also included in the assay. Compound 3 exhibited pronounced activity against the clinically-relevant S. aureus as well as against B. subtilis comparable to that of the reference standard (streptomycin). Compound 2 was also highly-active against S. aureus . By comparing the structures of the three new compounds ( 1 – 3 ), it was revealed that altering the substitutions at C-10 and C-2 can significantly increase the antibacterial activity of 1 . [ABSTRACT FROM AUTHOR]
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- 2014
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6. In vitro cytotoxic activity of isolated acridones alkaloids from Zanthoxylum leprieurii Guill. et Perr
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Ngoumfo, Rostand M., Jouda, Jean-Bosco, Mouafo, Ferdinand T., Komguem, Justin, Mbazoa, Céline D., Shiao, Tze Chieh, Choudhary, Mohammed I., Laatsch, Hartmut, Legault, Jean, Pichette, André, and Roy, René
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CELL-mediated cytotoxicity , *ZANTHOXYLUM , *ACRIDINE , *BIOLOGICAL assay , *CANCER cells , *SPECTRUM analysis , *CHLOROFORM , *THERAPEUTICS ,THERAPEUTIC use of alkaloids - Abstract
Abstract: Chemical investigation of the roots and fruits of Zanthoxylum leprieurii Guill. et Perr. led to the isolation of three new alkaloids including two acridone derivatives, 3-hydroxy-1,4-dimethoxy-10-methyl-9-acridone (2) and 3-hydroxy-1,2-dimethoxy-10-methyl-9-acridone (3) named helebelicine A and B, respectively, and one secobenzo[c]phenantridine, 10-O-demethyl-12-O-methylarnottianamide (10), together with thirteen other compounds. The structures of compounds 2, 3 and 10 as well as those of the known compounds were elucidated by using spectroscopic methods and by comparison with reported data. The brine-shrimp (artemia salina) lethality bioassay of the chloroform extract of the fruits showed modest cytotoxicity with LD50 at 13.1μg/mL. Isolated compounds 1, 4–6 were found to be moderately active against lung carcinoma cells (A549), colorectal adenocarcinoma cells (DLD-1) and normal cells (WS1) with IC50 values ranging from 27 to 77μM. In contrast to the positive control etoposide used, the cytotoxicity of the most active compound 4 was found to be selective against cancer cells in comparison to normal cells WS1 with IC50 of 51±8μM and 4.3±0.4μM, respectively. [Copyright &y& Elsevier]
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- 2010
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7. Pentacyclic triterpenoids and other constituents isolated from the leaves of Gambeya lacourtiana and their antibacterial activity.
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Talla, Rostan Mangoua, Jouda, Jean-Bosco, Mbazoa, Céline Djama, Kapche, Gilbert Deccaux Wabo Fotso, Lenta, Bruno Ndjakou, Sewald, Norbert, and Wandji, Jean
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ANTIBACTERIAL agents , *TRITERPENOIDS , *SALMONELLA typhi , *TRADITIONAL medicine , *CHLOROPHYLL , *PHYTOCHEMICALS , *EPICATECHIN - Abstract
The phytochemical study was done on the leaves of Gambeya lacourtiana. This plant has been used in traditional medicine to treat of different ailments such as uterine heamorrhage, metritis and other vaginal infections. Chromatographic fractionation and purification on the leaves crude extract afforded lupeol acetate (1), lupenone (2), lupeol (3), taraxerol (4) stigmasterol (5), erythrodiol (6), chamaedrydiol (7), methyl pheophorbide-a (8), corosolic acid (9), tormentic acid (10), epicatechin (11) and 22-dihydrospinasterol 3- O - β - D -glucopyranoside (12). The structures of compounds 1 – 12 were elucidated on the basis of 1D and 2D NMR, mass spectrometric and the spectroscopic data as well as comparison with the literature. Compounds 4 , 7 – 10 and 12 were isolated for the first time from Gambeya genus. Crude extract, fractions and compounds 6–12 were evaluated for their antibacterial activity. Methyl pheophorbide-a (8) demonstrated moderate activity against Salmonella typhi CPC with MIC values of 62.5 μg/mL. The chemophenetic significance of these compounds is also discussed. [Display omitted] • Isolation of 12 compounds from the leaves of Gambeya lacourtiana (Sapotaceae). • First report of a chlorophyll type skeleton in the genus Gambeya. • First antibacterial report of the leaves of Gambeya lacourtiana. [ABSTRACT FROM AUTHOR]
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- 2021
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8. Phytochemical analysis of the stems of Angylocalyx oligophyllus (Baker) Baker f. (Fabaceae).
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Kweka Wakeu, Brussine Nadège, Talla, Rostan Mangoua, Jouda, Jean-Bosco, Foudjo Melacheu, Gertrude Laura, Muhammad, Shaiq Ali, Wandji, Jean, and Mbazoa, Céline Djama
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LEGUMES , *BETULINIC acid , *URSOLIC acid , *MASS spectrometry - Abstract
The phytochemical investigation of the CH 2 Cl 2 /MeOH (1:1) crude extract from the stems of Angylocalyx oligophyllus (Baker) led to the isolation and characterization of 2 α ,3 α ,24-trihydroxyolean-12-en-28-oïc acid (1), 2 α ,3 α ,24-trihydroxyolean-11,13(18)-dien-28-oic acid (2) betulinic acid (3), ursolic acid (4), lupeol (5), lupenone (6), 8- O -methylretusin (7), 3-methoxydainzein (8), afromosin (9), β -sitosterol (10), β -sitosterol 3- O - β - D -glucopyranoside (11), and α - D -glucopyranosyl- O -(1 → 2)- β - D -fructofuranoside (12). The structures of compounds 1 – 12 were elucidated on the basis of 1D and 2D NMR, mass spectrometry and the spectroscopic data as well as comparison with the literature. All the isolated compounds (1 – 12) were reported for the first time from the genus Angylocalyx. Compounds 1 and 2 are reported from the Fabaceae family for the first time. The chemophenetic significance of these compounds is also discussed. The stems of Angylocalyx oligophyllus (Baker) Baker f. and isolated compounds. [Display omitted] • Isolation of twelve compounds from the stem of Angylocalyx oligophyllus Baker. (Fabaceae). • First report in these compounds from the genus Angylocalyx. • First report of two compounds from the Fabaceae family. [ABSTRACT FROM AUTHOR]
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- 2022
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9. Chemical constituents of Mussaenda erythrophylla Schumach. & Thonn. (Rubiaceae) and their chemophenetic significance.
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Bouzeko, Inest Larissa T., Dongmo, Faustine Léonie M., Ndontsa, Blanche Laure, Ngansop, Cyrille Armel N., Keumoe, Rodrigue, Bitchagno, Gabin Thierry M., Jouda, Jean Bosco, Mbouangouere, Roukayatou, Tchegnitegni, Billy Toussie, Boyom, Fabrice Fekam, Sewald, Norbert, Lenta, Bruno Ndjakou, Tane, Pierre, Ngouela, Silvère Augustin, and Tene, Mathieu
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RUBIACEAE , *QUINIC acid , *ETHYL acetate , *ACID derivatives , *AMPHOTERICIN B , *TRITERPENOIDS , *HEXANE - Abstract
The chemical investigation of the CH 2 Cl 2 /MeOH (1:1) extract from the aerial part of Mussaenda erythrophylla Schumach. & Thonn. (Rubiaceae) resulted in the isolation of sixteen known compounds (1 – 16) distributed in coumarins, flavonoid glucosides, quinic acid derivatives, triterpenoids, monoglycerid, steroids, tetraterpenoid and polyol. The structures of the compounds were determined by spectrometric and spectroscopic analysis including MS and NMR data followed by their comparison with reported ones in the literature. The chemophenetic significance of the isolated compounds was discussed. The crude extract and some of the isolated compounds were assessed in vitro for their antileishmanial, cytotoxic and antiplasmodial activities. The crude extract of M. erythrophylla showed moderate antileishmanial activity (IC 50 = 61.6 μg/mL) while the hexane soluble fraction showed good antileishmanial activity (IC 50 = 31.06 μg/mL) compared to the reference drug amphotericin B (IC 50 = 0.11 μM). Compounds 11 and 9 also exhibited potent antileishmanial activity (IC 50 = 53.7–52.0 μM). The crude extract as well as the ethyl acetate soluble fraction also exhibited good antiplasmodial activity (IC 50 = 7.43 ± 0.00 μg/mL and 14.49 ± 2.96 μg/mL respectively), while compounds 11 , 15 and 16 showed weak activity with IC 50 > 20 μM compared to the reference drug artemisinin (IC 50 = 0.014 ± 0.001 μM). [Display omitted] • Sixteen compounds isolated from aerial of Mussaenda erythrophylla. • The chemophenetic significance of isolates were studied. • Structures were cleared by extensive NMR and MS techniques. • Isolates showed moderate to significant cytotoxicity towards the parasites. • Compounds were low to moderate active against the parasites. [ABSTRACT FROM AUTHOR]
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- 2021
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10. Rothmanniamide and other constituents from the leaves of Rothmannia hispida (K.Schum.) fagerl. (Rubiaceae) and their chemophenetic significance.
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Nkwenti Wonkam, Argan Kelly, Njanpa Ngansop, Cyrille Armel, Njonte Wouamba, Steven Collins, Jouda, Jean Bosco, Happi, Gervais Mouthe, Boyom, Fabrice Fekam, Sewald, Norbert, and Lenta, Bruno Ndjakou
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RUBIACEAE , *GLYCOSIDES , *LEISHMANIA donovani , *URSOLIC acid , *METABOLITES , *GLUCOSIDES - Abstract
The chemical investigation of the CH 2 Cl 2 /MeOH (1:1) extract of the leaves of Rothmannia hispida (K. Schum.) Fagerl. (Rubiaceae) led to the isolation of a new ceramide rothmanniamide (1) and a naturally isolated alkyl cinnamate derivative n -heptadecyl-4-hydroxy- trans -cinnamate (2), along with fifteen known compounds including lupeol palmitate (3), lupeol (4), a mixture of uvaol (5) and erythrodiol (6), ursolic acid (7), 30- nor -2 α, 3 β -dihydroxyurs-12-ene (8), hederagenin (9), stigmast-22-en-3-ol (10), a mixture of β -sitosterol (11) and stigmasterol (12), stigmast-4,22-dien-3-ol (13), stigmasterol 3- O - β -D-glucoside (14), triacontan-1-ol (15), kaempferol 3- O - β -D-glucopyranoside (16) and D-mannitol (17). Their structures were elucidated with the help of MS and NMR data. Compounds 8 , 10 and 15 were isolated for the first time from the Rubiaceae family. The crude extract and the isolates were assessed in vitro for their antileishmanial activity against Leishmania donovani 1 S (MHOM/SD/62/1 S) promastigotes and cytotoxicity on RAW 264.7 macrophage cells. Compounds 7 and 8 exhibited a highly potent antileishmanial activity with IC 50 values of 0.88 and 1.75 μg/mL, respectively, with good selectivity indexes (SI > 57). The chemophenetic significance of these compounds is also discussed. Image 1 • New secondary metabolites in Rothmannia hispida (K. Schum.) Fagerl. (Rubiaceae). • Three compounds were isolated for the first time from the Rubiaceae family. • Antileishmanial compounds from R. hispida. • The chemophenetic significance of the isolated compounds was discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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