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Research in developed countries has found that paternal involvement has positive and significant effects on early childhood development (ECD). Less is known, however, about the state of paternal involvement and its influence on ECD in rural China. Using data collected in Southern China that included 1,460 children aged 6-42 months and their fathers (as well as their primary caregivers), this study examines the association between paternal involvement and ECD. Although the results demonstrate that the average level of paternal involvement is low in rural China, paternal involvement is related to a significant increase in three domains of ECD (cognition, language, and social-emotional skills). Older children benefit significantly more than do younger children from paternal involvement in all domains of ECD. The results also show that, if the mother is the primary caregiver, the mother's higher educational level and the family's higher socioeconomic status are positively associated with paternal involvement.

Rare and endangered species have narrow geographical distributions and are vulnerable to environmental changes. Studying the impact of future climate change on their distributions and identifying areas of high conservation priority are key to halting biodiversity loss. In this study, we combined a species distribution model with systematic conservation planning to simulate the suitable distributions of rare and endangered vascular plants and vertebrates in Inner Mongolia in the current and future (the 2050s), analyzed the vulnerability of species, and identified areas with high conservation priority. Currently, species richness (SR) of vascular plant was high in the Greater Khingan Mountains, and SR of vertebrates was high on the Hulunbuir Plateau, which are two species-rich areas. By 2050, 41.8% to 54.6% of vascular plants will have a reduced suitable distribution area, versus 46.8% to 51.1% for vertebrates. Vascular plant SR increased significantly in the Mu Us Desert, which became a new species-rich area. Vertebrate SR increased in western Inner Mongolia, but species-rich areas changed little. Species-rich areas are also potentially affected by future land use change, particularly in grassland, forest, and cropland areas with high SR. The current priority biodiversity conservation area covers 12.27 × 104 km2, of which 80.6% is located outside existing protected areas. By 2050, this percentage may increase to 83.4%. Our study revealed the potential pressure of existing protected areas in protecting biodiversity under future climate change, which helps decision-makers develop the most appropriate development strategies in advance to promote China's sustainable development. [ABSTRACT FROM AUTHOR]

Despite rapid economic growth in China since 1978, rural-urban inequality has widened. High levels of socioeconomic inequality can have profound implications for child development and lifelong educational equity. Using a dataset containing early childhood development (ECD) outcomes of 0- to 3-year-olds (N = 9,053) from study sites in Eastern, Central, and Western China, the study finds that the risks of cognitive, language, and motor delay are, respectively, 43.2, 18.3, and 20.7 percentage points higher in rural study sites than in urban Shanghai (ps <.01). Impact evaluation of cluster-randomized experiments shows that parental training (focusing on child psychosocial stimulation and caregiver-child interaction) can improve parenting beliefs and practices (or investments) and ECD outcomes of disadvantaged rural children (p<.01). Such programs can play an important role in advancing progress toward more social equality and economic equity, the stated goals of China's "Common Prosperity" policy. [ABSTRACT FROM AUTHOR]

Summary: Phosphorus (P) fertilization can alleviate a soil P deficiency in grassland ecosystems. Understanding plant functional traits that enhance P uptake can improve grassland management.We measured impacts of P addition on soil chemical and microbial properties, net photosynthetic rate (Pn) and nonstructural carbohydrate concentrations ([NSC]), and root P‐uptake rate (PUR), morphology, anatomy, and exudation of two dominant grass species: Leymus chinensis (C3) and Cleistogenes squarrosa (C4).For L. chinensis, PUR and Pn showed a nonlinear correlation. Growing more adventitious roots compensated for the decrease in P transport per unit root length, so that it maintained a high PUR. For C. squarrosa, PUR and Pn presented a linear correlation. Increased Pn was associated with modifications in root morphology, which further enhanced its PUR and a greater surplus of photosynthate and significantly stimulated root exudation (proxied by leaf [Mn]), which had a greater impact on rhizosheath micro‐environment and microbial PLFAs.Our results present correlations between the PUR and the Pn of L. chinensis and C. squarrosa and reveal that NSC appeared to drive the modifications of root morphology and exudation; they provide more objective basis for more efficient P‐input in grasslands to address the urgent problem of P deficiency. [ABSTRACT FROM AUTHOR]

Much attention has been given to the change rule of a single extreme event, and there are few reports on comprehensive characteristics of multiple extreme events in a certain region. Based on the analyzes of annual frequency of extreme high temperature, extreme low temperature, extreme drought, extreme precipitation, and extreme typhoon events in China from 1961 to 2020, a multi extreme events composite risk grade index (MXCI) was constructed and applied to the comprehensive characteristics analyzes of multiple extreme events in China. The results show that the high value areas of MXCI were mainly located in southeast China and southwest China. Over the past 60 years, the MXCI has shown a decreasing trend in western China and most of southeastern China, and an increasing trend in the middle zone from southwest China to northeast China. Through comparative analysis, MXCI can objectively reflect the comprehensive characteristics of multiple extreme climate events in a region, which is helpful to understand regional extreme climate characteristics and effectively cope with extreme climate risks. [ABSTRACT FROM AUTHOR]

Global warming has constituted a major global problem. Carbon dioxide emissions from the burning of fossil fuels are the main cause of global warming. Therefore, carbon dioxide emission forecasting has attracted widespread attention. Aiming at the problem of carbon dioxide emissions forecasting, this paper proposes a new hybrid forecasting model of carbon dioxide emissions, which combines the marine predator algorithm (MPA) and multi-kernel support vector regression. For further strengthening the prediction accuracy, a novel variant of MPA is proposed, called EGMPA, which introduces the elite opposition-based learning strategy and the golden sine algorithm into MPA. Algorithm test results show that EGMPA can effectively improve the convergence speed and optimization accuracy. The carbon dioxide emission data of China from 1965 to 2020 are taken as the research objects. Root-mean-square error (RMSE), mean absolute error (MAE), and mean absolute percentage error (MAPE) are used to evaluate the performance of the proposed model. The proposed multi-kernel support vector regression model is used to forecast China's carbon dioxide emissions during the "14th Five-Year Plan" period. The results show that the proposed model has RMSE of 37.43 Mt, MAE of 30.63 Mt, and MAPE of 0.32%, which significantly improves the prediction accuracy and can accurately and effectively predict China's carbon dioxide emissions. During the "14th Five-Year Plan" period, China's carbon dioxide emissions will continue to show an increasing trend, but the growth rate will slow down significantly. [ABSTRACT FROM AUTHOR]

Research in developed countries has found that paternal involvement has positive and significant effects on early childhood development (ECD). Less is known, however, about the state of paternal involvement and its influence on ECD in rural China. Using data collected in Southern China that included 1,460 children aged 6–42 months and their fathers (as well as their primary caregivers), this study examines the association between paternal involvement and ECD. Although the results demonstrate that the average level of paternal involvement is low in rural China, paternal involvement is related to a significant increase in three domains of ECD (cognition, language, and social-emotional skills). Older children benefit significantly more than do younger children from paternal involvement in all domains of ECD. The results also show that, if the mother is the primary caregiver, the mother's higher educational level and the family's higher socioeconomic status are positively associated with paternal involvement. [ABSTRACT FROM AUTHOR]

For the day-by-day evaporation observation data in the Yangtze River Basin from 1951 to 2019, the effects of the gradual shift of observation instruments from 20 cm diameter evaporation pan (D20) to E601 evaporation pan after 1980 are discussed, including inconsistent data series, and missing and anomalous data. This study proposes a governance and improvement method for dual-source evaporation data (GIME). The method can accomplish the homogenization of data from different observation series and solve the problem of inconsistent and missing data, and we applied it in practice on data of the Yangtze River Basin. Firstly, the primary and secondary periods of the data were obtained by wavelet periodicity analysis; secondly, we considered the first cycle of observations to be representative of the sample and calculated the conversion relationship between the primary and secondary periods; thirdly, the conversion coefficient between the dual-source observations was calculated, and the results were corrected for stations outside the main cycle; finally, the daily evaporation dataset of E601 pan was established through data fusion and interpolation technology. The study found that the annual average conversion coefficients of the D20 and E601 pans in the Yangtze River Basin are basically between 0.55 and 0.80, and there are obvious differences in different regions. The conversion coefficient is positively correlated with relative humidity, wind speed, minimum temperature and altitude; and negatively correlated with sunshine duration, average temperature and maximum temperature. Evaporation is high in the upper reaches of the basin and low in the middle and lower reaches; in particular, evaporation is highest in the southwest, which is associated with the drought hazards. In addition, the article presents the spatial distribution of the conversion coefficients of D20 and E601 pans in the Yangtze River Basin. The results can realize the rapid correction of the evaporation data of the local meteorological department, and can be extended to the processing of other types of data in similar areas. [ABSTRACT FROM AUTHOR]

Dongting Lake, an important wintering habitat for migratory waterbirds in the East Asian–Australasian Flyway, has suffered serious degradation in recent decades. To restore habitats for biodiversity conservation and flood control, 459 dykes were demolished and 14 were preserved in 2017. However, the direct impact of dyke demolition on wintering waterbirds was not comprehensively assessed. In this study, based on annual waterbird census and habitat data (2013/14–2020/21), we compared the differences in habitat areas and species composition of waterbirds in the dyke‐demolished and preserved areas, and explored whether habitat changes caused by the dyke demolition were responsible for the changes in the number of species and percentages of waterbird individuals. The results indicate that the areas of water (including shallow water) and mudflat habitats significantly decreased, but the vegetation area significantly increased in the dyke‐demolished areas. The species numbers and percentages of waterbird individuals at the community and foraging guilds levels, and the percentages of nine species, were higher in the dyke‐preserved areas than those in the dyke‐demolished areas. Changes in the numbers of species and percentages of individuals of fish eaters, insectivores, and omnivores positively correlated with drastic changes in the percentages of water habitats (including shallow water) after dyke demolition. Effective measures should be carried out to restore hydrological regimes, providing waterbirds sufficient suitable habitats with different water depths. These findings improve our understanding of the influence of dyke demolition on waterbirds and provide insights for wetland management and waterbird conservation. [ABSTRACT FROM AUTHOR]

Background: The increasing numbers of women in the workforce is an inevitable trend in China. More and more employed women stop breastfeeding because of working stressors. Many mothers, however, overcome the challenges and insist on breastfeeding after returning to work. Their individual experience of breastfeeding may provide a new insight to promote and support breastfeeding on employed mothers. This study sought to understand mothers' experience with insisting on breastfeeding after returning to work based on Kumpfer's Resilience Framework in Chinese context. Methods: This qualitative study was designed with semi-structured interviews. Purposive sampling and snowball sampling were employed to recruit 13 full-time working mothers with a stable job in the public sector who continued to breastfeed for 1 month or longer after returning to work in Haikou, Hainan Province, China. Interviews were conducted from January to March 2020 to capture participants' experiences of breastfeed after returning to work. Grounded theory and Kumpfer's Resilience Framework were used to analyze data via a systematic and iterative process. Results: Employed mothers built resilience while continuing to breastfeed after returning to work. The core concept was "dynamic interaction". Other categories were the background and explanation of this phenomenon. For working mothers who continued to breastfeed, resilience involved "dynamic interaction", which started from "experiencing stressors" and "obtaining support", two environmental factors interacted with the individual to "build resilience qualities", which interact with environment led to "behavioral resilience". And then the ongoing dynamic interaction between behavioral resilience and environment ultimately led to three different "weaning processes", including natural weaning, active weaning, and forced weaning. Conclusions: This study identified the framework of resilience in mothers who were in the adversity of breastfeeding after returning to work based on Kumpfer's Resilience Framework. It provided a new insight into the resilience of employed mothers around the world to continue breastfeeding and showed the different culture of breastfeeding on employed mothers. [ABSTRACT FROM AUTHOR]

Background: Jujube (Ziziphus jujuba Mill.) fruit is one of the largest productions in China and its increasing production has drawn considerable attention from researchers. Polysaccharide is one of the most abundant components of jujube, and it represents a major group of biolotegically active constituents. This study intended to investigate the special structure of a homogeneous acidic polysaccharide (PZMP4) produced from Ziziphus Jujuba cv. Muzao fruit using novel methods, including DEAE-Sepharose Fast Flow and Sephacryl S-300 column chromatography. Results: The structure of PZMP4 was determined via high-performance gel permeation chromatography (HPGPC), gas chromatography (GC), Fourier transform infrared spectroscopy (FT-IR), methylation analysis, nuclear magnetic resonance spectroscopy (NMR), scanning electron microscopy (SEM), and atomic force microscopy (AFM). The results reveal that PZMP4 with a molecular weight of 27.90 kDa was composed of rhamnose, arabinose, mannose, glucose, galactose, and galacturonic acid at a ratio of 2.32:2.21:0.22:0.88:2.08:8.83. Advanced structural analysis revealed a netted structure with molecular aggregates of PZMP4. Structural features demonstrated that the basic backbone of PZMP4 appeared to mainly consist of (1→4)-linked GalpA with three branches bonded to O-3 of (1→3)-linked Araf, (1→2)-linked Rhap, and terminated with GalpA. Conclusions: PZMP4's unique structure could imply distinct bioactivities and have considerable utilization in functional food. Highlights: Structural characteristics of PZMP4 were analyzed by HPGPC, GC, FT-IR, GC-MS, NMR, SEM and AFM. PZMP4 mainly consisted of (1→4)-linked GalpA with three branches boned to O-3. The branches included (1→3)-linked Araf, (1→2)-linked Rhap, and terminated with GalpA. [ABSTRACT FROM AUTHOR]

The growing popularity of plant-based milk alternatives has driven the creation of many novel products to meet the consumers' diverse requirements. Red kidney bean (Phaseolus vulgaris L.) is an underutilized legume that might be used to develop a novel plant-based milk alternative due to its high protein content and diverse health benefits. It has demonstrated that the stability and sensory properties of plant-based milk were significantly affected by the cultivars of the raw material. The objectives of this study were unique to compare the physicochemical stability and sensory characteristics of plant-based milk from four different red kidney bean varieties grown in China. Furthermore, the possible differential mechanisms were explored by analyzing the rheological properties, protein solubility, surface hydrophobicity, surface tension, and microstructure of red kidney bean milk. The results showed that compared with the other three red kidney bean varieties, Jizhangyun-2 (JZY-2) exhibited excellent physicochemical stability with a lower centrifugal sedimentation rate (8.04%), smaller particle size distribution (2.54 μm), and higher potential (−23.03 mV). Furthermore, the enhanced protein solubility and surface hydrophobicity, as well as the decreased surface tension and aggregation degree of protein in JZY-2 kidney bean milk were deemed to be responsible for the results. The color and sensory analysis also supported that the JZY-2 kidney bean was suitable to prepare a novel plant-based milk alternative. • Plant-based milk alternatives were produced from four different red kidney bean varieties. • Four red kidney bean milk showed different stability and sensory properties. • Differences in stability and sensory properties were attributed to proteins. • The JZY-2 red kidney bean was more suitable for the production of plant-based milk alternatives. [ABSTRACT FROM AUTHOR]

Much attention has been given to the large-scale anthropogenic influence on extreme temperature changes. However, the possible effects of atmospheric factors and the role of the locally anthropogenic driver on the observed regional change in extreme temperatures have not been well understood. Datasets of the China Meteorological Administration (CMA) were used to examine the possible influence. The data include the homogenized surface air maximum/minimum temperature, surface sunshine duration (SSD), water vapor pressure (VAP), and total cloud cover (CLO) during 1961–2020. We calculated the seasonal means of maximum temperature (Tx (mean)), minimum temperature (Tn (mean)) and diurnal temperature range (DTR) to analyze the characteristics of extreme surface air temperature (ESAT) changes in winter and summer, and their relationship to SSD, VAP , and CLO , as well as the urbanization effect in the extreme temperature indices series. The changes in the trends for SSD and VAP were more closely correlated with ESAT in winter and summer, respectively. The decreasing of SSD led to a slowing of the ESAT warming, while an increase of the VAP led to the intensification of ESAT warming. In addition, CLO also had an important role in the change of ESAT. The seasonal mean correlation coefficient over China mainland between Tn (mean) and VAP were statistically significant and higher than those with SSD and CLO. The seasonal mean correlation between Tx (mean) / DTR and SSD were also statistically significant. The SSD and VAP strongly influenced the Tx (mean) in winter. The urbanization contribution to the DTR trends reached >25% in both winter and summer. SSD strongly influenced the trend of ESAT in urban area whereas CLO/VAP had larger influence on the trend of ESAT in rural area, which were all related to the urbanization effect as observed in the data series. • The decreasing of sunshine duration and increasing of the water vapor led to a slowing and the intensification of the extreme temperature warming, respectively. • The correlation coefficient between minimum temperature and water vapor were statistically significant. The correlation between maximum temperature / diurnal temperature range and sunshine duration were statistically significant. • The trend of sunshine duration strongly influenced on the trend of extreme temperature in urban area, whereas the trend of cloud cover and water vapor had more influence in rural area. [ABSTRACT FROM AUTHOR]

The heart of biogas industry is on, with going on transformation and upgrading. Upgraded biogas, namely biomethane, is a low-carbon, clean, safe and efficient renewable energy, which very often has been neglected in energy debate. However, it shows great contributions to promoting the transformation and upgrading of energy structure and energy security, building an ecological civilization, etc. The successful business cases in Europe have displayed many reasons to keep developing this sector. Hence, taking China as an example, this work aims to benefit the government and energy transition stakeholders more broadly in working together to enable and manage successful biogas industry transition with the experience of European countries. This includes how policymakers can help to guarantee the healthy development of biomethane industry, and what the government and companies can do to boost the market, economy and technology of biomethane. The ultimate target is to prosper the world's biomethane industry to meet people's ever-growing demands for a better life and a beautiful environment. • Biomethane industry is the inevitable way of biogas industry development. • The future direction of biomethane industry should include energy, environment and human health. • Biomethane industry needs to innovate on the existing biogas industry. • The top-level design needs to be in place, and detailed policies need to follow. [ABSTRACT FROM AUTHOR]

Based on the homogenized daily data of 2255 meteorological stations during the past 60 years from 1961 to 2020, the potential evapotranspiration was calculated using the revised FAO56 Penman–Monteith model, and then the annual AI (aridity index, the ratio of annual potential evapotranspiration to annual precipitation) was employed to analyze the dry-wet climate change in China. The GCM models' prediction data was used to analyze the possible trends of dry-wet climate in China by the end of this century. The results showed that in the past 60 years, the climate in China was getting wetter, especially in the western regions of China, including Xinjiang, western Qinghai, Gansu, western Inner Mongolia, and northwestern Tibet. In the last 10 years, China's climate has become more humid. Compared with the 1960s, the total area of aridity has decreased by about 650,000 square kilometers. The changes of different climate zones have regional and periodical characteristics. There was a tendency to get wet periods in all four seasons, especially in summer. Analysis of GCM model projection data shows that by the end of this century, the climate in China would have a general trend of becoming drier. The drier regions are mainly located in the central and eastern parts of China, while the western regions of China continue to maintain the wetting trends. In the case of high emissions, the trends of drying in the central and eastern and wetting in the west are more significant than in the case of medium emission. [ABSTRACT FROM AUTHOR]

• Home-visiting interventions have positive effects on child cognitive development, parenting beliefs and parenting practices of caregivers in rural China. • Home-visiting interventions have null effects on child social-emotional development in rural China. • Three mechanisms are identified through which interventions are able to raise child cognitive development. • Shifting parenting beliefs; increasing parenting practices; and shifting parenting beliefs thus fostering better parenting practices of primary caregivers are the three mechanisms that are driving our overall results of the impact of home-visiting interventions on early child development. To better understand the impacts of parenting interventions (e.g., parental training of psychosocial stimulating activities) on child developmental outcomes and design effective policies to benefit young children, it is essential to identify the mechanisms through which the interventions work. To this end, this paper presents the results of two randomized controlled trials that offered home visitation, parenting trainings to 435 households (with 527 households as the control group) in 174 villages across three provinces in China. The findings from the randomized controlled trials showed that the interventions significantly improved child cognitive development and had a positive effect on the primary caregivers' parenting practices and their parenting beliefs. The analysis suggests three possible mechanisms through which the parenting interventions affected child cognitive development: changing the parenting beliefs of the primary caregivers, shifting the parenting practices of the primary caregivers, and improving the primary caregivers' parenting beliefs, thus fostering better parenting practices. [ABSTRACT FROM AUTHOR]

Background: Social-emotional development during the first three years of life is associated with later social-emotional development and cognitive development. In rural China, research has found large shares of children under age three are developmentally delayed, yet little is known about the paths of social-emotional development before age 3 or how developmental paths predict later social-emotional skills and cognitive skills.Aims: To investigate the paths of child social-emotional development during ages 0-3 and examine how different paths predict social-emotional development and cognitive development at preschool age.Methods: Three waves of longitudinal panel data from 1245 children in rural Western China was collected. Child social-emotional development was measured by the Ages and Stages Questionnaire: Social-Emotional. Child cognitive development was measured by the Bayley Scales of Infant Development and by the Wechsler Preschool and Primary Scale of Intelligence-Fourth Edition. Four paths of child social-emotional development were classified: "never" social-emotionally delayed; "persistently" social-emotionally delayed; "improving," or "deteriorating."Results: 331 (27%) were never social-emotionally delayed; 373 children (30%) were persistently social-emotionally delayed; 149 children (12%) experienced improving social-emotional development; and 392 children (31%) experienced deteriorating social-emotional development. Children who were never social-emotionally delayed or who were on an "improving" path had higher social-emotional development at preschool age (p < .01). Children who were persistently social-emotionally delayed (p < .5) and on a deteriorating path (p < .01) had lower social-emotional development at preschool age. Children on the persistently delay path also were shown to have lower levels of cognitive development at preschool age (p < .01).Conclusions: Different paths of child social-emotional development before age 3 are associated with different social-emotional and cognitive development at preschool age. [ABSTRACT FROM AUTHOR]

The aim of this study was to investigate the therapeutic effect of cryoablation treatment in advanced NSCLC patients who had failed first-line chemotherapy. Eighty-seven patients from ten hospitals in China were enrolled into the study, forty-four patients received cryoablation treatment plus basic treatment (experimental group), and forty-three patients had basic treatment alone (control group). Follow-up was performed once every three months until the end of the study or the death of the patient. The primary endpoints were overall and post-intervention survival; secondary endpoints included tumor markers, solid tumor efficacy, and symptom changes before and after treatment. There was no significant difference in median OS between the two groups of patients (9.0 months vs 11.2 months, P = 0.583). The disease control rate (DCR) and living quality of the experimental group was higher than that of the control group. In terms of OS, indiscriminate use of cryoablation for such patients was not beneficial, though it could improve symptoms of patients. Cryoablation had a significant effect on selected advanced NSCLC patients after the failure of first-line chemotherapy. [ABSTRACT FROM AUTHOR]

Grazing has a profound impact on the availability of soil resources like carbon (C), nitrogen (N), and phosphorus (P) in grasslands. These changes can potentially make it difficult to meet microbial elemental demands, thus affecting microbial C use efficiency (CUE) and soil C dynamics. Nevertheless, it remains unclear how soil microbes respond to stoichiometric imbalances and their consequent effect on microbial CUE. In this study, we investigated the stoichiometry of soil labile resources, microbial biomass, extracellular enzymes, as well as the microbial community composition and microbial CUE, microbial respiration, microbial quotient (q MB), and soil organic carbon (SOC) changes, at sites with four grazing intensities (no grazing, light, medium, and heavy grazing) in a temperate steppe of northern China. Grazing led to decreased stoichiometric imbalances between soil labile resources and microbial biomass, thereby exacerbating limitations of available C on soil microbes. To alleviate this limitation of C, microbes raised the microbial threshold elemental ratios and microbial biomass, and increased fungi dominance rather than increased activities of C-, N-, and P- acquiring enzymes due to increased microbial own growth. Microbes also improved microbial CUE, q MB, and microbial respiration while decreasing SOC under increasing grazing intensity. These integrated adaptations denote that grazing can reduce SOC which is closely affected by soil microbial C utilization induced by resource change conditions despite the increased microbial biomass contribution to SOC. These findings illustrate the regulation of stoichiometric imbalances in soil C dynamics driven by microbes under grazing and improve our understanding of how stoichiometric changes influences soil C flows in semi-arid grassland. [Display omitted] • Grazing lowered stoichiometric imbalances but increased microbial C limitation. • Microbes decreased C-, N-, P-acquiring enzymes for limiting nutrients acquisition. • Microbes increased their biomass, threshold elemental ratios, and fungi:bacteria. • Aggravated grazing induced increased CUE, q MB, and microbial own growth. • Adaptative pathways of microbes resulted a decline of SOC. [ABSTRACT FROM AUTHOR]

• Introduce an evaluation approach for the Ecological Service Value of Water (ESV-W). • Improve the assessment of Ecosystem Services Value (ESV) by introducing the Agricultural Price Index (API) into the Equivalence Factor (EF). • Improve the Water Allocation and Simulation Model (WAS) to simulate and quantify the 'natural-artificial' soil water cycle. • Analysis of the ESV and ESV-W in the Yangtze River Basin from 2005 to 2020. This paper introduces an evaluation approach for the Ecological Service Value of Water (ESV-W) by coupling the assessment of Ecosystem Services Value (ESV) with the Water Allocation and Simulation Model (WAS). The proposed method is applied to evaluate ESV and ESV-W in the Yangtze River Basin from 2005 to 2020. Firstly, an improved Equivalence Factor (EF) method is employed to estimate ESV by considering different land use types and service categories. Then, the enhanced WAS model is used to quantify and identify the role of the 'natural-artificial' soil water cycle in supporting the ecological service functions. Finally, by integrating the ESV evaluation system with the WAS model, the evaluation method for ESV-W is established. The results indicated that from 2005 to 2020, the total ESV increased from 4.0 to 5.6 trillion US Dollars, with forests being the primary contributor among land use types (about 52%), and regulating services are dominating among service categories (about 70%). The spatial distribution of the ESV showed a decreasing trend from southeast to northwest in the Yangtze River Basin, while the ESV-W exhibited high values concentrated along the main stream of the upper reaches of the Yangtze River and lower in the middle. The ESV-W of the 'natural' soil water cycle still dominates (over 96%), but the ESV-W of the 'artificial' soil water cycle has been rapidly increasing in recent years. In 2020, the ESV-W per unit water of precipitation, irrigation, and ecological water were 4.0 Dollars/ m 3 , 0.7 Dollars/ m 3 , and 32.4 Dollars/ m 3 , respectively. This study aims to provide references for the protection of water ecosystems and the sustainable utilization of water resources. It also serves as a reference for improving the evaluation system of ESV. [ABSTRACT FROM AUTHOR]

Global climate has undergone dramatic changes over the past 200 years, accurately identifying the climate transition (from LIA to 20th century warming) and its controlling factors will help to address the risks posed by global warming. Detailed analyses of chronology, grain size, color reflectance (L*, a*) and carbon content (TOC, TIC) were conducted on a 200-year sedimentary record from lake Ebinur in Xinjiang, northwest China. The results show that lake sediments are mainly transported by wind, and there are two kinds of different sources and transport processes. Comparative analysis of multi-proxies reveals that the climate transition took place in 1920 AD. In the early period (1816–1920 AD), the high C values indicate strong transport dynamics; the high proportion of ultrafine component indicates strong pedogenesis, combined with high TOC and a* values, it is inferred that the climate is cold and wet. In the later period (1920–2019 AD), the proxies show opposite changes, which may reveal a warm and dry climate. Based on a comprehensive analysis of multi-drivers, we propose that the increase of solar irradiance played a dominant role in 1920 AD climate transition, and the gradual rise in the concentrations of greenhouse gases may have a positive feedback effect. • Lake Ebinur sediments are mainly transported by wind. • A climate transition occurred in 1920 AD: from cold LIA to 20th century warming. • The increase of solar irradiance is the main driver of the 1920 AD climate transition. [ABSTRACT FROM AUTHOR]

Ecological security (ES) can express the health and integrity of regional ecosystems; hence, a better understanding of regional ES levels and their influencing factors can help to specify sustainable ecological management policies. Levels of ES in the West Liao River Basin were computed for the years of 2000 to 2020 at both the grid and county scale by using the pressure–state–response model, with ecosystem services also included in the assessment system. From 2000 to 2020, the area of both the forests and grasslands increased, due to the Grain for Green Project, which augmented net primary productivity (NPP), an ecosystem production service, and enhanced the overall habitat quality of the basin and promoted improvements to the regional ecological environment. The ES levels in most areas of the West Liao River Basin were improved over time, in that >90% of its area was above the middle level in 2020. The coordinates of "very insecure" moved to the basin's southeast, while "very secure" moved to its northwest, which indicated serious ES problems in the southeast of the basin. When compared with the most economically developed areas or remote areas having societal progress and human activities, generally the moderately developed areas have better ES levels. Further, human factors are more important to ES than natural factors, though all driving factors had enhanced impacts on the change in ES via their interactive effects. By determining the ES levels of the basin, four ecological management zones were then derived for it. We identified the main environmental problems in each ecological management zones and put forward the corresponding management measures, which would make the results more useful for supporting resource management and ecological protection of ecologically fragile areas in the agriculture and pasture interlaced landscape of northern China. • Ecological security levels were improved in most areas of the West Liao River Basin. • Moderately developed areas have better ecological security levels. • From 2000 until 2020, the gravity center of ecological security changed. • Human factors are more important to ecological security than natural factors. • Including ecosystem services can better quantify the ecological security status. [ABSTRACT FROM AUTHOR]

Poncirus polyandra , a plant species with extremely small populations in China, has become extinct in the wild. This study aimed to identify functional genes that improve tolerance to abiotic and biotic stresses. Here, we present a high-quality chromosome-scale reference genome of P. polyandra. The reference genome is 315.78 Mb in size, with an N50 scaffold size of 32.07 Mb, and contains nine chromosomes with 20,815 protein-coding genes, covering 97.82% of the estimated gene space. We identified 17 rapidly evolving nucleotide-binding-site (NBS) genes, three C-repeat-binding factors (CBF) genes, 19 citrus greening disease (Huanglongbing, HLB) tolerance genes, 11 citrus tristeza virus (CTV) genes, and one citrus nematode resistance gene. A divergence time of 1.96 million years ago was estimated between P. polyandra and P. trifoliata. This is the first genome-scale assembly and annotation of P. polyandra , which will be useful for genetic, genomic, and molecular research and provide guidance for the development of conservation strategies. • The whole-genome sequence of Poncirus polyandra is 315.78 Mb with scaffold N50 of 32.07 Mb. • 17 rapidly evolving NBS genes, three CBF genes, 19 HLB tolerance genes, 11 CTV genes, and one citrus nematode resistance gene were identified. • A divergence time of 1.96 million years ago between P. polyandra and P. trifoliata was estimated. [ABSTRACT FROM AUTHOR]

Anthropogenic activities have made phosphorus (P) a new sustainability issue globally. To better understand the mechanisms of soil P dynamics responding to inorganic P fertilization (0–12.5 g P m−2yr−1), we conducted a 2-year field experiment in a temperate grassland in northern China. The P fertilizer was added once per year before the growth period as NaH 2 PO 4. We randomly collected topsoil samples (0–10 cm) and analyzed the soil properties, microbial community, and extracellular enzyme activities, and quantified the soil P fractions using solution 31P nuclear magnetic resonance (31P NMR) spectroscopy. P application promoted transformation from organic P to inorganic P driven by microbial carbon (C) demand and regulated by altered soil properties and microbial characteristics. P addition decreased orthophosphate diesters, especially DNA, due to increased hydrolysis under increased soil pH. This may increase hydrolysates such as α - glycerophosphate and choline phosphate. Orthophosphate monoesters, especially myo -inositol hexaphosphate, also decreased following increased P availability. This could be explained by increased alkaline phosphatase activity and reduced sorption due to a decreased metal (Ca, Al, and Fe) content. Furthermore, P fertilization increased soil NH 4 +-N, thereby increasing the growth of phosphonate-solubilizing microorganisms (Bacillus, Streptomyces, Bradyrhizobium, Mesorhizobium, Penicillium, Aspergillus , and Fusarium). Their increased growth also contributed to inorganic P solubilization and organic P mineralization due to their P-solubilizing specificity. Together, these factors increased inorganic P, especially orthophosphate, which was temporarily immobilized in microbial cells, to regulate the soil-solution P supply, and created a potentially available P sink in the grassland. • Microbial C demand drove transformations from organic P to inorganic P. • Increased soil pH stimulated the hydrolysis of diesters, especially DNA. • Monoesters decreased due to altered alkaline phosphatase activity and metal content. • Soil NH 4 +-N stimulated the growth of phosphonate-solubilizing microorganisms. • Orthophosphate immobilized in microbes regulated the soil solution's P supply. [ABSTRACT FROM AUTHOR]

• Authoritative parenting style is significantly and positively associated with preschool-aged child cognitive development. • Authoritarian parenting style is significantly and negatively associated with preschool-aged child cognitive development. • Mothers, more educated, and higher SES caregivers are more likely to use authoritative parenting style. • Authoritative parenting style has greater benefits in terms of cognitive development for girls than boys. The correlation between parenting style and child cognitive development has been widely documented in Western societies. There has been far less research, however, in non-Western societies and none at all in rural China. This study aimed to investigate the association between parenting style and child cognitive development in rural China. Participants were 1272 preschool-aged children and their primary caregivers. Children were 49 to 65 months old (51% male), and all were ethnically Han. Primary caregivers reported their parenting style, and children were assessed on their cognitive skills. Two alternative approaches (two dimensions and four categories) were used to examine the correlation between parenting style and child cognitive development. The results show a positive correlation between an authoritative parenting style and child cognitive development and show a negative correlation between an authoritarian parenting style and development. When the mother is the primary caregiver, more educated, or from a wealthier family, she is more likely to use an authoritative parenting style and less likely to use an authoritarian one. In addition, the authoritative style has a stronger correlation with the cognitive developmental outcomes of girls than of boys. The findings encourage researchers to conduct future work on how to implement parenting training interventions that are able to ascertain whether parents in rural China can be taught to adopt an authoritative parenting style. Future research should also seek to identify whether an authoritative parenting style produces (in a causal manner) any significant long-term benefits to the cognitive development of children in rural China. [ABSTRACT FROM AUTHOR]

• We use five-wave panel datasets to examine the effects of maternal migration on children's cognition. • The cognition developments were measured by BSID-I and WPPSI-VI. • Maternal migration has negative effects on the cognition of preschool-aged children. • Possible mechanisms include a generational shift in parenting and feeding practices. Preschool-aged children account for over 38 per cent of those left behind. Previous research suggests that maternal migration during early childhood may create a greater negative impact, however, the literature on the effect of maternal migration on cognitive development of preschool aged children is rare. This study uses a unique panel dataset following children from infancy to 63 months and their caregivers to estimate the causal effects of maternal migration on the critical cognitive development of children left behind. We find that maternal migration increases the probability of cognitive delay by six percentage points. Possible mechanisms include a generational shift in parenting and feeding practices leading to reduced engagement in stimulating activities and dietary diversity. To the best of our knowledge, this is the first study to examine the causal effects of maternal migration on cognition during the first six years of life in rural China. [ABSTRACT FROM AUTHOR]

• P limitation under grazing was driven by plant compensatory growth and soil P loss. • Available P concentration in the rhizosphere was increased under grazing. • Plant requirement for P stimulated its transition from organic into inorganic P. • LMWOAs and mycorrhizal fungi mobilized the rhizosphere P. • A medium grazing intensity is conducive to grassland's sustainable development. Soil erosion and phosphorus (P) removal due to livestock production have led to a grave depletion of P in grasslands. Accordingly, understanding how plants cope with such P limitation conditions and which P transition processes operate in the soil under different grazing intensities is imperative for better scientific management of grazed grasslands. Here, we conducted a field experiment that tested the impact of different grazing intensities (light, medium, and heavy) and a control (no grazing) on P-related dynamics in a typical temperate grassland site in Inner Mongolia, China. The increased N:P ratio in leaves of dominant plant species and higher annual primary production (APP) of vegetation that generally ensued under grazing indicated that plants' compensatory growth in response to grazing pressure was a factor contributing to P limitation. Plants' P requirement for growth stimulated P transition in the rhizosphere via the mobilization of low-molecular-weight organic acids (LMWOAs) and mycorrhizal fungi. Specifically, LMWOAs promoted the conversion of stable P into organic P, and mycorrhizal fungi converted that organic P into labile P in the rhizosphere. This P transition process is jointly affected by changes to key soil physiochemical properties and the altered P input from excrement caused by herbivores. Altogether, these results suggest that grazing increases the biological vitality of the soil and accelerates the transition of P in the rhizosphere; and a medium grazing intensity may be more suitable for agricultural production because it provides the highest APP and a more biologically dynamic soil environment. [ABSTRACT FROM AUTHOR]

Anthropogenic activities have increased ecosystem phosphorus (P) inputs and have affected terrestrial ecosystem carbon (C) cycles. However, the fate of soil organic C (SOC) under P addition remains elusive, and the potential mechanisms underlying plant-microbial linkages mediated SOC formation and decomposition are poorly understood. Here, we conducted a field P fertilization experiment to explore the effects on SOC dynamics in a typical temperate grassland in northern China. P addition increased soil P availability and pH, thereby stimulating plant nutrient uptake and growth, leading to higher C inputs to soils via plant biomass (shoots, litter and roots). However, P addition exacerbated microbial N limitation, altered microbial community composition (with a lower fungal to bacterial ratio), shifted microbial life-history strategies, which transitioned from the K -strategy (Acidobacteria, Chloroflexi, and Verrucomicrobia dominant) to the r - strategy (Proteobacteria, Bacteroidetes, and Firmicutes dominant), and modulated their functional characteristics. All of these factors regulated microbial substrate preferences and changed the C components that undergo decomposition. These changes ultimately accelerated the utilization of active C, hampered passive C decomposition, and helped to create a longer-term stable C sink in the grassland. • P addition decreased active C and increased passive C and this resulted in a net increase of SOC. • Increased plant productivity and litter quality improved plant C inputs to the soil. • Altered microbial characteristics regulated their substrate preference, thus stimulating active C loss. • Decreased soil metallic elements may partially weaken the stability of SOC. • Accumulated passive C would be beneficial in creating a longer-term stable C sink. [ABSTRACT FROM AUTHOR]

Carbon (C) assimilation and allocation play a crucial role in determining plant responses to environmental stress such as herbivory. However, the pattern how these grasses allocate assimilated C under increasing herbivory intensity hasn't been fully understand. In this study, we quantified photosynthetic C assimilation and allocation of newly assimilated C among tissues and metabolic processes (structural growth, storage, and defense) under different grazing intensities using 13C tracing of a dominant grass species, Leymus chinensis. Light grazing promoted utilization of newly-assimilated 13C (more than 90% 13C allocated to aboveground tissues on first day after labeling), photosynthetic rate, and reduced mean residence time of 13C of L. chinensis. The photosynthetic capacity and regulation of chlorophyll fluorescence thereby C assimilation were constrained under medium and heavy grazing. Light grazing also increased accumulation of non-structural carbohydrates (NSC) in stems for energy supply to leaf regeneration. As herbivory pressure increased, 13C tracing showed preferential allocation of newly assimilated C to belowground tissues (16–27% 13C on first day after labeling), while upregulating leaf defenses by increasing secondary metabolites and in root storage by NSC accumulation. Although the significant changes showed in C allocation to storage and secondary metabolism of L. chinensis , there are no difference in structural growth (defined as structural biomass= biomass - NSC – secondary metabolites) among grazing intensities. Overall, L. chinensis adopted a conservative C-allocation strategy (upregulated C storage and secondary metabolism) that emphasized long-term survival under increasing herbivory. Light grazing was an optimal grazing intensity that promoted structural growth and C allocation of L. chinensis , which could sustain and even increase grassland productivity. These characteristics of the plant's C allocation strategy provide new insights into the C budget of grassland ecosystems and increase our understanding of the role of C fixation and partitioning when plants respond to environmental challenges. [Display omitted] • Carbon (C) assimilation and allocation was evaluated by 13C tracing technique. • More 13C allocated to aboveground tissues for photosynthesis under light grazing. • Light grazing promoted C fixation and turnover of leaves and NSC storage of stems. • Under grazing pressure L. chinensis increased NSC storage across organs. • The production of SM increased in leaves as increasing herbivory pressure. [ABSTRACT FROM AUTHOR]

Cognitive and social-emotional development in the first three years of life is associated with later skills. However, little is known about the paths of developmental delays in both cognitive and social-emotional skills before age 3 or to what extent these paths predict later developmental outcomes. The aim of this study is to examine the associations between the different paths of developmental delays in both cognitive and social-emotional skills of children before age 3 and the levels of development of the children when they are preschool age. Using a longitudinal data collected at three time points from 1245 children and their caregivers in rural China, we identified four different paths of developmental delays in cognitive and social-emotional before age 3 and examined how these paths are associated with different levels of developmental outcomes at preschool age. We used a non-parametric standardization approach and an ordinary least squares model to perform our analyses. Findings show that rates of developmental delays in either cognitive or social-emotional domain or both domains are high at all different time points, ranging from 20% to 55% for cognitive delays and 42% to 61% for social-emotional delays. Over half of children experienced deteriorating levels of either cognitive or social-emotional development before age 3. A large share of children was found to be persistently delayed in either domain. Only a small share of children raised their levels of development in either domain before age 3. In addition, we identified certain socioeconomic status of the family that are associated with never or deteriorating path of child developmental delays. More importantly, we revealed that different paths of developmental delays before age 3 have predictive power on different levels of developmental outcomes at preschool age. Our results suggest that actions are needed at the earliest times to improve child development when children are still infants or toddlers., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2024 Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)

The association of cardio-ankle vascular index (CAVI), with subclinical cardiac dysfunction in hypertensive patients is unclear. We aim to examine their relationship in hypertensive patients compared with that in normotensive subjects. Our study included 1887 subjects enrolled from Danyang between 2018 and 2019. CAVI was measured using VaSera VS-1500A device. We performed conventional echocardiography to measure ejection fraction (EF) and E/A, tissue Doppler to measure mitral annular early diastolic velocities (e'), and speckle-tracking to estimate left ventricular (LV) global longitudinal strain (GLS). LV mass index (76.3, 80.0, and 84.0 g/m 2 ), and E/e' (7.6, 8.2, and 8.8) were increased and GLS (21.1, 21.0, and 20.4%), E/A (1.2, 1.0, and 0.8) and e' velocity (11.2, 9.4, and 8.2 cm/s) was decreased from tertiles 1-3 of CAVI on unadjusted analyses (P < .001). After adjustment for covariates, GLS, E/A, and e' were still significantly decreased from tertiles 1-3 of CAVI (P ≤ .04). Further sensitive analyses revealed a similar association pattern for diastolic function but not systolic function. Compared with the lowest tertile, subjects with a top tertile of CAVI were at higher risk of subclinical LV systolic dysfunction in hypertensive patients (OR = 2.61; P = .005). Increased CAVI is associated with worse subclinical diastolic function. However, this relationship of CAVI to subclinical systolic function was more prominent in hypertensive patients., (© 2024 The Authors. The Journal of Clinical Hypertension published by Wiley Periodicals LLC.)

Background: Poor development of young children is a common issue in developing countries and it is well established that iron deficiency anemia is one of the risk factors. Research has shown that iron deficiency is a common micronutrient deficiency among children in rural China and can result in anemia. A previous paper using data from the same trial as those used in the current study, but conducted when sample children were younger, found that after 6 months of providing caregivers of children 6-11 months of age free access to iron-rich micronutrient powder (MNP) increased the hemoglobin concentrations (Hb) of their children. However, no effects were found 12 and 18 months after the intervention. The current study followed up the children four years after the start of the original intervention (when the children were 4-5 years old) and aims to assess the medium-term impacts of the MNP program on the nutritional status of the sample pre-school-aged children, including their levels of Hb, the prevalence of anemia, and the dietary diversity of the diets of the children., Methods: At baseline, this study sampled 1,802 children aged 6-11 months in rural Western China. The intervention lasted 18 months. In this medium-term follow-up study that successfully followed 81% (n = 1,464) of children (aged 49-65 months) from the original study population 4 years after the start of the intervention, we used both intention-to-treat (ITT) effect and average treatment on the treated effect (ATT) analyses to assess the medium-term impacts of the MNP distribution program on the nutritional status of sample children., Results: The ITT analysis shows that the MNP intervention decreased the prevalence of anemia of young children in the medium run by 8% (4 percentage points, p < 0.1). The ATT analysis shows that consuming 100 (out of 540) MNP sachets during the initial intervention led to a decrease in anemia of 4% (2 percentage points, p < 0.1). Among children with moderate anemia at baseline (Hb < 100 g/L), the intervention reduced the probability of anemia by 45% (9 percentage points, p < 0.1), and, for those families that complied by consuming 100 (out of 540) sachets, a 25% (5 percentage points, p < 0.05) reduction in the anemia rate was found. The MNP intervention also led to a persistent increase in dietary diversity among children that were moderately anemic at baseline. The results from the quantile treatment effect analysis demonstrated that children with lower Hb levels at baseline benefited relatively more from the MNP intervention., Conclusions: The findings of the current study reveal that the MNP intervention has medium-term effects on the nutritional status of children in rural China. The impacts of the MNP program were relatively higher for children that initially had more severe anemia levels. Hence, the implications of this study are that programs that aim to increase caregiver knowledge of nutrition and improve their feeding practices should be encouraged across rural China. Families, policymakers, and China's society overall need to continue to pay more attention to problems of childhood anemia in rural areas. This is particularly crucial for families with moderately anemic children at an early age as it can significantly contribute to improving the anemia status of children across rural areas of China., Trial Registration: ISRCTN44149146 (15/04/2013)., (© 2024. The Author(s).)

Objective: Our study aims to examine the associations of visceral adipose tissue (VAT) and epicardial adipose tissue (EAT) with subclinical cardiac dysfunction in a Chinese population., Design: Cross-sectional., Background: EAT and VAT are the most important ectopic fat pools which were previously shown to be associated with subclinical cardiac dysfunction. However, few studies simultaneously measured both EAT thickness and VAT area, and explored their associations with cardiac dysfunction. Our study aims to examine the associations of VAT and EAT with subclinical cardiac dysfunction in a Chinese population., Methods: The study subjects were recruited from Danyang County from 2018 to 2019. Using Philips CX50, we recorded EAT thickness at the end-systole in a long-axis view. The subclinical systolic and diastolic function were assessed by two-dimensional speckle tracking, and transmitral and tissue Doppler imaging, respectively. Using Omron HDS-2000, we measured VAT area by dual bioelectrical impedance analysis., Results: The 1558 participants (age, 52.3±12.8 years) included 930 (59.7%) women. Compared with women, men had higher VAT area (99.4 vs 70.1 cm 2 ; p<0.0001) but lower EAT thickness (4.02 vs 4.46 mm; p<0.0001). In simple correlation analyses, EAT thickness and VAT area were positively associated with E/e' ratio (r=0.16 to 0.20; all p<0.0001) and negatively with global longitudinal strain (GLS) and e' (r=-0.12 to -0.37; all p<0.0001). Furthermore, VAT area was associated with left ventricular ejection fraction (LVEF) (r=-0.14; p<0.0001). After adjustment for confounding factors, the association of EAT with GLS and that of VAT with e' and E/e' ratio remained significant (all p≤0.001), whereas the associations of EAT with subclinical diastolic dysfunction and that of VAT with systolic function became non-significant (all p≥0.11). Analyses on further adjustment for LVEF showed similar results., Conclusions: Increased EAT thickness was associated with worse subclinical systolic dysfunction, while greater VAT area was associated with early diastolic dysfunction., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)

Scleroderma yunnanense, an ectomycorrhizal fungus, is a popular edible mushroom within the Yunnan Province of Southwest China that holds great ecological and economic implications. However, despite its significance, there remains limited information about this species. Therefore, we sequenced S. yunnanense genome to identify the functional genes of S. yunnanense involved in secondary metabolite and carbohydrate production pathways. First, we present the 40.43 Mb high-quality reference genome for S. yunnanense, distributed across 35 contigs; moreover, the N50 contig size was found to reach 3.31 Mb and contained 8877 functional genes. Finally, genome annotation was conducted to compare the functional genes of S. yunnanense with protein sequences from different publicly available databases. Taken together, we identified 12 biosynthetic gene clusters across 10 contigs; among these were 13 key mevalonate (MVA) pathway enzymes, a key tyrosinase enzyme in the 3,4-dihydroxyphenylalanine (DOPA) pathway that is responsible for producing DOPA melanins, and 16 enzymes involved in uridine diphosphate glucose biosynthesis. Overall, this study presents the first genome assembly and annotation of S. yunnanense; ultimately, this information will be important in the elucidation of the biological activities and artificial domestication of this fungus., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.)

Phosphorus (P) fertilization can alleviate a soil P deficiency in grassland ecosystems. Understanding plant functional traits that enhance P uptake can improve grassland management. We measured impacts of P addition on soil chemical and microbial properties, net photosynthetic rate (P n ) and nonstructural carbohydrate concentrations ([NSC]), and root P-uptake rate (PUR), morphology, anatomy, and exudation of two dominant grass species: Leymus chinensis (C 3 ) and Cleistogenes squarrosa (C 4 ). For L. chinensis, PUR and P n showed a nonlinear correlation. Growing more adventitious roots compensated for the decrease in P transport per unit root length, so that it maintained a high PUR. For C. squarrosa, PUR and P n presented a linear correlation. Increased P n was associated with modifications in root morphology, which further enhanced its PUR and a greater surplus of photosynthate and significantly stimulated root exudation (proxied by leaf [Mn]), which had a greater impact on rhizosheath micro-environment and microbial PLFAs. Our results present correlations between the PUR and the P n of L. chinensis and C. squarrosa and reveal that NSC appeared to drive the modifications of root morphology and exudation; they provide more objective basis for more efficient P-input in grasslands to address the urgent problem of P deficiency., (© 2023 The Authors New Phytologist © 2023 New Phytologist Foundation.)

Background: Hearing loss is considered one of the most common sensory nervous system defects, about 60% of which are caused by genetic factors. Mutations in the GSDME gene are responsible for post-lingual, progressive, autosomal dominant hearing loss. This study aimed to characterize the genetic mutations and clinical features of a Chinese GSDME family., Methods: After clinical evaluations, high-throughput DNA sequencing was conducted using DNA samples from this family. Sanger sequencing was performed to verify the suspected variants. A detailed genotype and phenotype analysis were carried out. Gene set enrichment analysis (GSEA) was performed to identify the signaling pathway associated with GSDME expression., Results: A known hotspot heterozygous splice-site variation (c.991-15&#95;991&#95;13delTTC) was identified and shown to segregate with the hearing loss phenotype in the family. This pathogenic splice-site variant results in skipping of exon 8. GSEA analysis identified changes in regulation of the cell cycle checkpoint, peroxisome, and amino acid metabolism signaling pathways., Conclusions: We identified a reported mutation in the GSDME gene. Our findings support the 3 bp deletion (c.991-15&#95;991-13del) was a hotspot variation, and it emerged as an essential contributor to autosomal dominant progressive hearing loss in East Asians. GSDME gene is closely associated with a range of signaling pathways. These characterized findings may provide new evidence for pathogenesis., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2022 Lei et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)

Tacrolimus (TAC) is an immunosuppressant widely used in kidney transplantation. TAC displays considerable interindividual variability in pharmacokinetics (PKs). Genetic and clinical factors play important roles in TAC PKs. We enrolled a total of 251 Chinese renal transplant recipients and conducted a genomewide association study (GWAS), linkage disequilibrium (LD), and one-way analysis of variance (ANOVA) to find genetic variants affecting log-transformed TAC trough blood concentration/dose ratio (log[C 0 /D]). In addition, we performed dual luciferase reporter gene assays and multivariate regression models to evaluate the effect of the genetic variants. The GWAS results showed that all 23 genomewide significant single-nucleotide polymorphisms (p < 5 × 10 -8 ) were located on chromosome 7, including CYP3A5*3. LD, conditional association analysis, and one-way ANOVA showed that rs75125371 T > C independently influenced TAC log(C 0 /D). Dual luciferase reporter gene assays indicated that rs75125371 minor allele (C) was significantly associated with increased normalized luciferase activity than the major allele (T) in the Huh7 cells (p = 1.2 × 10 -5 ) and HepaRG cells (p = 0.0097). A model inclusive of age, sex, hematocrit, CYP3A5*3, and rs75125371 explained 37.34% variance in TAC C 0 . These results suggest that rs75125371 T > C is a functional and population-specific variant affecting TAC C 0 in Chinese renal transplant recipients., (© 2022 The Authors. Clinical and Translational Science published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics.)

This paper examines the impact of parental beliefs on child development outcomes (for both cognitive and social−emotional skills) based on a three-wave longitudinal survey in rural China. The survey waves were conducted when the sample children were 18−30 months, 22−36 months, and 49−65 months, respectively. A total of 815 children and their primary caregivers who participated in all three wave surveys were enrolled in this study. Using difference-in-differences and propensity score matching approaches, the results indicate that strengthened parental beliefs have a positive and significant impact on child social−emotional development. Specifically, between the periods of the Wave 1 survey (when children were 18−30 months old) and the Wave 3 survey (when children were 49−65 months old), and between the Wave 2 survey (when children were 22−36 months old) and the Wave 3 survey, strengthened parental beliefs were causally associated with more favorable child social−emotional scores by 0.44 SD (p < 0.01) and 0.49 SD (p < 0.01), respectively. No significant impact, however, was found between the period of the Wave 1 survey and the Wave 2 survey. In contrast, weakened parental beliefs had a negative and significant impact on child social−emotional development. Specifically, weakened parental beliefs were causally associated with worse child social−emotional abilities by 0.35 SD (p < 0.01), 0.30 SD (p < 0.01), and 0.22 (p < 0.05) for the time period of the Wave 1 to Wave 2, Wave 1 to Wave 3, and Wave 2 to Wave 3, respectively. No significant impact of parental beliefs, however, was found on child cognitive development. In addition, the findings of the mediation analysis show that only a marginal impact of parental beliefs on child social−emotional development can be indirectly explained by parental beliefs through parenting practices. This study calls on policy makers to improve parental beliefs and parenting practices in the hope that it will lead to better child development in rural China.

Moisture evolution in Central Asia including Northwest China shows less similarity with its surroundings and attracts a growing number of studies. In this study, a well-dated thick lacustrine sequence is chosen in Northwest China and detailed geochemical analysis is conducted during the Middle Miocene Climate Transition (MMCT, 14-11 Ma). The multi-proxy records (Na2O/Al2O3, CIA, Rb/Sr) revealed that chemical weathering was the strongest during 11.85-11 Ma, the coldest period in 14-11 Ma as evidenced by the global deep-sea oxygen isotope records. Accordingly, we conclude that global climate cooled during MMCT and reached the coldest during 11.85-11 Ma. Thus, the westerly circulation became the strongest during this period, which brought more water vapor to Northwest China and the chemical weathering was significantly improved. On the other hand, the significant decrease in temperature led to the marked weakening of evapotranspiration, and thus the effective humidity was relatively increased. Both aspects contribute greatly to the significant enhancement of chemical weathering in eastern Central Asia. This weathering history of the sediments in the northeastern Tibetan Plateau is of great scientific significance to understanding tectonism and climate change in Asia during MMCT., Competing Interests: The authors have declared that no competing interests exist.

Using a three-wave longitudinal survey conducted in 815 households in rural Western China, this study aims to examine the association between parental self-perception and early childhood development and the mediation effect of parental investment on the association between parental self-perception and child development when the sample children are at different ages in the early childhood (18-30, 22-36, and 49-65 months). The results demonstrate that parental self-perception are positively and significantly associated with child social-emotional development in all three ages of childhood (from 18 to 65 months). Positive and significant association between parental self-perception and child cognitive development is found in the ages from 22 to 65 months. In addition, findings of this study show that parental investment plays a mediating role in the association between parental self-perception and child cognitive development. The study calls on policymakers to help to strengthen parental self-perception and parental investment related to early childhood development, which should result in better child development in rural China., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Wang, Wang, Li, Guo, Hu, Zhang and Rozelle.)

Adenovirus, respiratory syncytial virus, and influenza virus are common causes of respiratory infections. The COVID-19 pandemic had a significant impact on their prevalence. The aim of this study was to analyze the epidemic changes of common respiratory viruses in the Affiliated Hospital of Hangzhou Normal University in Hangzhou, China, from October of 2017 to February of 2021. We collected statistics from 121,529 patients in the outpatient and inpatient departments of the hospital who had throat or nose swabs collected for testing for four virus antigens by the colloidal gold method. Of these, 13,200 (10.86%) were positive for influenza A virus, 8,402 (6.91%) were positive for influenza B virus, 6,056 (4.98%) were positive for adenovirus, and 4,739 (3.90%) were positive for respiratory syncytial virus. The positivity rates of the influenza A virus (0-14 years old, P = 0.376; over 14 years old, P = 0.197) and respiratory syncytial virus (0-14 years old, P = 0.763; over 14 years old, P = 0.465) did not differ significantly by gender. After January of 2020, influenza virus infection decreased significantly. The positivity rate of respiratory syncytial virus remained high, and its epidemic season was similar to before. Strict respiratory protection and regulation of crowd activities have a great impact on the epidemic characteristics of viruses. After major changes in the public health environment, virus epidemics and their mutations should be monitored closely, extensively, and continuously., (© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.)