1. Correlation of Serum Prolactin and Thyroid Stimulating Hormone Concentration in Infertile Women: A Systematic Review and Meta-Analysis.
- Author
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DELINI DEVI RAMADRAS, NOOR AZLIN AZRAINI CHE SOH@YUSOF, NAJIB MAJDI YAACOB, WAN NORLINA WAN AZMAN, and HANISAH ABDUL HAMID
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RISK assessment , *REPRODUCTIVE health , *INFERTILITY , *META-analysis , *CHI-squared test , *THYROID hormones , *PROLACTIN , *SYSTEMATIC reviews , *MEDLINE , *THYROTROPIN , *WOMEN'S health , *ONLINE information services , *CONFIDENCE intervals , *DISEASE risk factors - Abstract
Infertility affects millions of people of reproductive age worldwide. Thyroid hormones and prolactin (PRL) affect reproduction and pregnancy; therefore, these two hormones influence fertility. This systematic review and meta-analysis aimed to summarise the strength of the correlation between serum PRL and thyroid stimulating hormone (TSH) in infertile women and to explore selected factors influencing the correlation. We conducted a systematic search of online databases (PubMed, Scopus, ScienceDirect, SAGE and Google Scholar) from inception until March 2021 and a manual search of the bibliographies of the included studies to identify relevant publications. The original research paper describing the correlation between PRL and TSH in reproductive-age women with infertility (primary and secondary) was included. The risk of bias was assessed using the Joanna Briggs Institute Critical Appraisal Checklist for Analytical Cross-Sectional Studies. A random effect model was used to estimate the pooled correlations of PRL and TSH, followed by an assessment of heterogeneity and a sensitivity analysis. From a total of 822 relevant articles identified, 11 were eligible and included in this systematic review and meta-analysis. The random effect pooled correlation estimates between PRL and TSH was 0.431 (95% CI: 0.251, 0.582), with substantial heterogeneity between the included studies (I² = 80%, τ ² = 0.067, P < 0.001). No significant publication bias was observed. Study region, types of infertility, sample size and year of the study did not influence the correlation estimates. Our results highlighted a significant positive moderate correlation between serum PRL and serum TSH in infertile women. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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