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164 results on '"Illario, Maddalena"'

2. Polypharmacy Management in Chronic Conditions: A Systematic Literature Review of Italian Interventions.

Author

Perrella, Lara, Mucherino, Sara, Casula, Manuela, Illario, Maddalena, Orlando, Valentina, and Menditto, Enrica

Subjects
ITALIAN literature, POLYPHARMACY, CHRONIC diseases, DRUG side effects, PATIENT compliance
Abstract

Background: Potentially inappropriate polypharmacy (PIP) is among the major factors leading to adverse drug reactions, increased healthcare costs, reduced medication adherence, and worsened patient conditions. This study aims to identify existing interventions implemented to monitor and manage polypharmacy in the Italian setting. Methods: A systematic literature review (PROSPERO: CRD42023457049) was carried out according to the PRISMA statement guidelines. PubMed, Embase, ProQuest, and Web of Science were queried without temporal constraints, encompassing all published papers until October 2023. Inclusion criteria followed the PICO model: patients with polypharmacy; interventions to monitor/manage polypharmacy regimen versus no/any intervention; outcomes in terms of intervention effectiveness and cost variation. Results: After duplicate deletion, 153 potentially relevant publications were extracted. Following abstract and full-text screenings, nine articles met the inclusion criteria. Overall, 78% (n = 7) were observational studies, 11% (n = 1) were experimental studies, and 11% (n = 1) were two-phase studies. A total of 44% (n = 4) of the studies involved patients aged ≥ 65 years, while 56% (n = 5) were disease-specific. Monitoring was the most prevalent choice of intervention (67%; n = 6). Outcomes were mainly related to levels of polypharmacy (29%; n = 6) and comorbidities (29%; n = 6), effectiveness rates (14%; n = 3), and avoidable costs (9%; n = 2). Conclusions: This review outlines that Italy is still lacking in interventions to monitor/manage PIP, addressing an unmet need in developing patient-tailored strategies for reducing health-system burden. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Next-generation ARIA care pathways for rhinitis and asthma: a model for multimorbid chronic diseases

Author

Bousquet, J. Jean, Schünemann, Holger J., Togias, Alkis, Erhola, Marina, Hellings, Peter W., Zuberbier, Torsten, Agache, Ioana, Ansotegui, Ignacio J., Anto, Josep M., Bachert, Claus, Becker, Sven, Bedolla-Barajas, Martin, Bewick, Michael, Bosnic-Anticevich, Sinthia, Bosse, Isabelle, Boulet, Louis P., Bourrez, Jean Marc, Brusselle, Guy, Chavannes, Niels, Costa, Elisio, Cruz, Alvaro A., Czarlewski, Wienczyslawa, Fokkens, Wytske J., Fonseca, Joao A., Gaga, Mina, Haahtela, Tari, Illario, Maddalena, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Le, L. T. T., Larenas-Linnemann, Desiree, Laune, Daniel, Lourenço, Olga M., Menditto, Enrica, Mullol, Joaquin, Okamoto, Yashitaka, Papadopoulos, Nikos, Pham-Thi, Nhân, Picard, Robert, Pinnock, Hilary, Roche, Nicolas, Roller-Wirnsberger, Regina E., Rolland, Christine, Samolinski, Boleslaw, Sheikh, Aziz, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valiulis, Arunas, Valovirta, Erkka, Vasankari, Tuula, Ventura, Maria-Teresa, Walker, Samantha, Williams, Sian, Akdis, Cezmi A., Annesi-Maesano, Isabella, Arnavielhe, Sylvie, Basagana, Xavier, Bateman, Eric, Bedbrook, Anna, Bennoor, K. S., Benveniste, Samuel, Bergmann, Karl C., Bialek, Slawomir, Billo, Nils, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Bonini, Mateo, Bonniaud, Philippe, Bouchard, Jacques, Briedis, Vitalis, Brightling, Christofer E., Brozek, Jan, Buhl, Roland, Buonaiuto, Roland, Canonica, Giorgo W., Cardona, Victoria, Carriazo, Ana M., Carr, Warner, Cartier, Christine, Casale, Thomas, Cecchi, Lorenzo, Cepeda Sarabia, Alfonso M., Chkhartishvili, Eka, Chu, Derek K., Cingi, Cemal, Colgan, Elaine, de Sousa, Jaime Correia, Courbis, Anne Lise, Custovic, Adnan, Cvetkosvki, Biljana, D’Amato, Gennaro, da Silva, Jane, Dantas, Carina, Dokic, Dejand, Dauvilliers, Yves, Dedeu, Antoni, De Feo, Giulia, Devillier, Philippe, Di Capua, Stefania, Dykewickz, Marc, Dubakiene, Ruta, Ebisawa, Motohiro, El-Gamal, Yaya, Eller, Esben, Emuzyte, Regina, Farrell, John, Fink-Wagner, Antjie, Fiocchi, Alessandro, Fontaine, Jean F., Gemicioğlu, Bilun, Schmid-Grendelmeir, Peter, Gamkrelidze, Amiran, Garcia-Aymerich, Judith, Gomez, Maximiliano, González Diaz, Sandra, Gotua, Maia, Guldemond, Nick A., Guzmán, Maria-Antonieta, Hajjam, Jawad, O’B Hourihane, John, Humbert, Marc, Iaccarino, Guido, Ierodiakonou, Despo, Illario, Maddalena, Ivancevich, Juan C., Joos, Guy, Jung, Ki-Suck, Jutel, Marek, Kaidashev, Igor, Kalayci, Omer, Kardas, Przemyslaw, Keil, Thomas, Khaitov, Mussa, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Kowalski, Marek L., Kritikos, Vicky, Kull, Inger, Leonardini, Lisa, Lieberman, Philip, Lipworth, Brian, Lodrup Carlsen, Karin C., Loureiro, Claudia C., Louis, Renaud, Mair, Alpana, Marien, Gert, Mahboub, Bassam, Malva, Joao, Manning, Patrick, De Manuel Keenoy, Esteban, Marshall, Gailen D., Masjedi, Mohamed R., Maspero, Jorge F., Mathieu-Dupas, Eve, Matricardi, Poalo M., Melén, Eric, Melo-Gomes, Elisabete, Meltzer, Eli O., Menditto, Enrica, Mercier, Jacques, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Moda, Giuliana, Mogica-Martinez, Maria-Dolores, Mohammad, Yousser, Montefort, Steve, Monti, Ricardo, Morais-Almeida, Mario, Mösges, Ralf, Münter, Lars, Muraro, Antonella, Murray, Ruth, Naclerio, Robert, Napoli, Luigi, Namazova-Baranova, Leila, Neffen, Hugo, Nekam, Kristoff, Neou, Angelo, Novellino, Enrico, Nyembue, Dieudonné, O’Hehir, Robin, Ohta, Ken, Okubo, Kimi, Onorato, Gabrielle, Ouedraogo, Solange, Pali-Schöll, Isabella, Palkonen, Susanna, Panzner, Peter, Park, Hae-Sim, Pépin, Jean-Louis, Pereira, Ana-Maria, Pfaar, Oliver, Paulino, Ema, Phillips, Jim, Picard, Robert, Plavec, Davor, Popov, Ted A., Portejoie, Fabienne, Price, David, Prokopakis, Emmanuel P., Pugin, Benoit, Raciborski, Filip, Rajabian-Söderlund, Rojin, Reitsma, Sietze, Rodo, Xavier, Romano, Antonino, Rosario, Nelson, Rottem, Menahenm, Ryan, Dermot, Salimäki, Johanna, Sanchez-Borges, Mario M., Sisul, Juan-Carlos, Solé, Dirceu, Somekh, David, Sooronbaev, Talant, Sova, Milan, Spranger, Otto, Stellato, Cristina, Stelmach, Rafael, Suppli Ulrik, Charlotte, Thibaudon, Michel, To, Teresa, Todo-Bom, Ana, Tomazic, Peter V., Valero, Antonio A., Valenta, Rudolph, Valentin-Rostan, Marylin, van der Kleij, Rianne, Vandenplas, Olivier, Vezzani, Giorgio, Viart, Frédéric, Viegi, Giovanni, Wallace, Dana, Wagenmann, Martin, Wang, De Y., Waserman, Susan, Wickman, Magnus, Williams, Dennis M., Wong, Gary, Wroczynski, Piotr, Yiallouros, Panayiotis K., Yorgancioglu, Arzu, Yusuf, Osman M., Zar, Heahter J., Zeng, Stéphane, Zernotti, Mario, Zhang, Luo, Zhong, Nan S., Zidarn, Mihaela, the ARIA Study Group, and the MASK Study Group

Published
2019
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6. Challenges in anti‐aging medicine–trends in biomarker discovery and therapeutic interventions for a healthy lifespan.

Author

Popescu, Iuliana, Deelen, Joris, Illario, Maddalena, and Adams, Jan

Subjects
AGING prevention, ACTIVE aging, OLDER people, CELLULAR aging, PHOSPHOPROTEIN phosphatases
Abstract

We are facing a growing aging population, along with increasing pressure on health systems, caused by the impact of chronic co‐morbidities (i.e. cancer, cardiovascular and neurodegenerative diseases) and functional disabilities as people age. Relatively simple preventive lifestyle interventions, such as dietary restriction and physical exercise, are important contributors to active and healthy aging in the general population. However, as shown in model organisms or in 'in vitro' conditions, lifestyle‐independent interventions may have additional health benefits and can even be conceived as possible reversers of the aging process. Thus, pharmaceutical laboratories, research institutes, and universities are putting more and more effort into finding new molecular pathways and druggable targets to develop gerotherapeutics. One approach is to target the driving mechanisms of aging, some of which, like cellular senescence and impaired autophagy, we discussed in an update on the biology of aging at AgingFit 2023 in Lille, France. We underline the importance of carefully and extensively testing senotherapeutics, given the pleiotropism and heterogeneity of targeted senescent cells within different organs, at different time frames. Other druggable targets emerging from new putative mechanisms, like those based on transcriptome imbalance, nucleophagy, protein phosphatase depletion, glutamine metabolism, or seno‐antigenicity, have been evidenced by recent preclinical studies in classical models of aging but need to be validated in humans. Finally, we highlight several approaches in the discovery of biomarkers of healthy aging, as well as for the prediction of neurodegenerative diseases and the evaluation of rejuvenation strategies. [ABSTRACT FROM AUTHOR]

Published
2023
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7. Exploratory Factor Analysis (EFA) of the Short Functional Geriatric Evaluation (SFGE) to Assess the Multidimensionality of Frailty in Community-Dwelling Older Adults.

Author

Liotta, Giuseppe, Lorusso, Grazia, Madaro, Olga, Formosa, Valeria, Gialloreti, Leonardo Emberti, Donnoli, Clara, Riccardi, Fabio, Orlando, Stefano, Scarcella, Paola, Apostolo, Joao, Silva, Rosa, Dantas, Carina, van Staalduinen, Willeke, De Luca, Vincenzo, Illario, Maddalena, Gentili, Susanna, and Palombi, Leonardo

Published
2023
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9. Assessment Tools of Biopsychosocial Frailty Dimensions in Community-Dwelling Older Adults: A Narrative Review.

Author

De Luca, Vincenzo, Femminella, Grazia Daniela, Patalano, Roberta, Formosa, Valeria, Lorusso, Grazia, Rivetta, Cristiano, Di Lullo, Federica, Mercurio, Lorenzo, Rea, Teresa, Salvatore, Elena, Korkmaz Yaylagul, Nilufer, Apostolo, Joao, Silva, Rosa Carla, Dantas, Carina, van Staalduinen, Willeke H., Liotta, Giuseppe, Iaccarino, Guido, Triassi, Maria, and Illario, Maddalena

Published
2022
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11. Digital Health Europe (DHE) Twinning on severe asthma-kick-off meeting report

Author

Bousquet, Jean, Bedbrook, Anna, Czarlewski, Wienczyslawa, De Carlo, Giuseppe, Fonseca, Joao A., Ballester, Miguel A. Gonzalez, Illario, Maddalena, Koskinen, Seppo, Laatikainen, Tiina, Onorato, Gabrielle L., Palkonen, Susanna, Patella, Vincenzo, Nhan, Pham-Thi, Puggioni, Francesca, Ventura, Maria Teresa, Joos, Guy, Kuna, Piotr, Louis, Renaud, Makris, Michael, Zalud, Petra, Zuberbier, Torsten, Bachert, Claus, Brussino, Luisa, Carreiro-Martins, Pedro, Carrion y Ribas, Carme, Chalubinski, Maciej, Costa, Elisio M., de Vries, Govert, Gemicioglu, Bilun, Gennimata, Dimitra, Micheli, Yann, Niedoszytko, Marek, Regateiro, Frederico S., Romantowski, Jan, Taborda-Barata, Luis, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Viart, Frederic, Laune, Daniel, HUS Inflammation Center, Department of Pathology, Department of Dermatology, Allergology and Venereology, and Helsinki University Hospital Area

Subjects
ALLERGIC RHINITIS, CHRONIC RESPIRATORY-DISEASES, POLICY DEVELOPMENT, ARIA, 3121 General medicine, internal medicine and other clinical medicine, education, INNOVATION PARTNERSHIP, MULTIMORBIDITY, IMPLEMENTATION, AIR-POLLUTION, GENERATION CARE PATHWAYS, PERSON-CENTERED CARE
Abstract

Non

Published
2021

12. Digital Health Europe (DHE) Twinning on severe asthma-kick-off meeting report

Author

Bousquet, Jean Bedbrook, Anna Czarlewski, Wienczyslawa De Carlo, Giuseppe Fonseca, Joao A. Ballester, Miguel A. Gonzalez and Illario, Maddalena Koskinen, Seppo Laatikainen, Tiina and Onorato, Gabrielle L. Palkonen, Susanna Patella, Vincenzo and Nhan, Pham-Thi Puggioni, Francesca Ventura, Maria Teresa and Joos, Guy Kuna, Piotr Louis, Renaud Makris, Michael and Zalud, Petra Zuberbier, Torsten Bachert, Claus Brussino, Luisa Carreiro-Martins, Pedro Carrion y Ribas, Carme and Chalubinski, Maciej Costa, Elisio M. de Vries, Govert and Gemicioglu, Bilun Gennimata, Dimitra Micheli, Yann and Niedoszytko, Marek Regateiro, Frederico S. Romantowski, Jan and Taborda-Barata, Luis Toppila-Salmi, Sanna Tsiligianni, Ioanna and Viart, Frederic Laune, Daniel

Published
2021

13. Report on SHAFE policies, strategies and funding

Author

Dantas, Carina, Illario, Maddalena, Paul, Cosmina, Cieśla, Agnieszka, Seifert, Alexander, Chikalanow, Alexandre, Haj Taieb, Amine, Perandres, Ana, Jaksić Stojanović, Andjela, Ferenczi, Andrea, Grgurić, Andrej, Klimczuk, Andrzej, Moen, Anne, Efthymiou, Areti, Poli, Arianna, Blazeviciene, Aurelija, Rexhepi, Avni, Garcia-Zapirain, Begonya, Benli, Berrin, Huesbp, Bettina, Berry, Damon, Pavlovski, Daniel, Lambotte, Deborah, Guardado, Diana, Todoroi, Dumitru, Shcherbakova, Ekateryna, Voropaev, Evgeny, Naselli, Fabio, Rotaru, Flaviana, Melero, Francisco, Matteo Apuzzo, Gian, Mijatović, Gorana, Marston, Hannah, Kelly, Helen, Belani, Hrvoje, Ljubi, Igor, Modlane Gorgenyi, Ildikó, Baraković Husić, Jasmina, Lumetzberger, Jennifer, Apóstolo, Joao, Deepu, John, Dinsmore, John, van Hoof, Joost, Lubi, Kadi, Valkama, Katja, Yamada, Kazumasa, Martin, Kirstin, Fulgerud, Kristin S., Lebar, Lea, Lhotska, Lenka, Angelini, Leonardo, Colonna, Liane, Gonzalez López, Lucia, Vidovićova, Lucie, Spiru, Luiza, Diaconu, Mara, Lyubenova, Mariyana, Cimbaljević, Marija, Dzida, Marija, Gosović, Marko, Fernandez, Marta, Kampel, Martin, Nagode, Mateja, Solarević, Milica, Zechner, Minna, Dmitrieva, Natali, Gapanovich-Kaidalov, Nikolai, Ovayolu, Nimet, Joransson, Nina, Durmishi Manahasa, Odeta, Ovayolu, Ozlem, Boland, Pauline, Roseiro, Pedro, Silva, Rosa, Cziker, Roxana Elena, Baraković, Sabina, Tomsone, Signe, Santana, Silvina, Hvalic-Touzery, Simona, Hansen, Sonja, Muller, Sonja, Danschutter, Stefan, Sharshakova, Tamara, Loncar-Turukalo, Tatjana, Vasiljev, Vanja, Lethola, Ville, Alexin, Zoltan, Staalduinen, Willeke van, and SHINE 2Europe

Subjects
Sozialwissenschaften, Soziologie, O33, Gerontologie, Alterssoziologie, D19, R58, O18, health, Sozialpolitik, Social Policy, Q58, Smart Healthy Age-Friendly Environments, wellbeing, smart, ddc:330, age-friendly, ddc:300, H54, Social sciences, sociology, anthropology, environments, Gerontology
Abstract

The objective of Working Group (WG) 4 of the COST Action NET4Age-Friendly is to examine existing policies, advocacy, and funding opportunities and to build up relations with policy makers and funding organisations. Also, to synthesize and improve existing knowledge and models to develop from effective business and evaluation models, as well as to guarantee quality and education, proper dissemination and ensure the future of the Action. The Working Group further aims to enable capacity building to improve interdisciplinary participation, to promote knowledge exchange and to foster a cross-European interdisciplinary research capacity, to improve cooperation and co-creation with cross-sectors stakeholders and to introduce and educate students SHAFE implementation and sustainability (CB01, CB03, CB04, CB05). To enable the achievement of the objectives of Working Group 4, the Leader of the Working Group, the Chair and Vice-Chair, in close cooperation with the Science Communication Coordinator, developed a template (see annex 1) to map the current state of SHAFE policies, funding opportunities and networking in the COST member countries of the Action. On invitation, the Working Group lead received contributions from 37 countries, in a total of 85 Action members. The contributions provide an overview of the diversity of SHAFE policies and opportunities in Europe and beyond. These were not edited or revised and are a result of the main areas of expertise and knowledge of the contributors; thus, gaps in areas or content are possible and these shall be further explored in the following works and reports of this WG. But this preliminary mapping is of huge importance to proceed with the WG activities. In the following chapters, an introduction on the need of SHAFE policies is presented, followed by a summary of the main approaches to be pursued for the next period of work. The deliverable finishes with the opportunities of capacity building, networking and funding that will be relevant to undertake within the frame of Working Group 4 and the total COST Action. The total of country contributions is presented in the annex of this deliverable.

Published
2021

14. ARIA digital anamorphosis: digital transformation of health and care in airway diseases from research to practice

Author

Bousquet, Jean, Anto, Josep M., Bachert, Claus, Haahtela, Tari, Zuberbier, Torsten, Czarlewski, Wienczyslawa, Bedbrook, Anna, Bosnic-Anticevich, Sinthia, Walter Canonica, G, Cardona, Victoria, ElisioCosta, Cruz, Alvaro A, Erhola, Marina, Fokkens, Wytske J, Fonseca, Joao A, Illario, Maddalena, CarlosIvancevich, Juan, Jutel, Marek, Klimek, Ludger, PiotrKuna, Kvedariene, Violeta, Le, Ltt, Larenas-Linnemann, Desiree, Laune, Daniel, Lourenço, Olga M, Melén, Eric, Mullol, Joaquim, Niedoszytko, Marek, Odemyr, Mikaëla, Okamoto, Yoshitaka, Papadopoulos, Nikos G, Patella, Vincenzo, Pfaar, Oliver, Pham-Thi, Nhân, Rolland, Christine, Samolinski, Boleslaw, Sheikh, Aziz, Sofiev, Mikhail, SuppliUlrik, Charlotte, Todo-Bom, Ana, Tomazic, Peter V, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valiulis, Arunas, Valovirta, Erkka, Ventura, Maria-Teresa, Walker, Samantha, Williams, Sian, Price, David, and Roberts, Graham

Abstract

Digital anamorphosis is used to define a distorted image of health and care that may be viewed correctly using digital tools and strategies. MASK digital anamorphosis represents the process used by MASK to develop the digital transformation of health and care in rhinitis.It strengthens the ARIA change management strategy in the prevention and managementof airway disease. The MASK strategy is based on validated digital tools. Using the MASK digital tool and the CARAT online enhanced clinical framework, solutions for practical steps of digital enhancement of care are proposed.

Published
2021

15. Digital transformation of health and care in airway diseases from research to practice

Author

Bousquet, Jean, Anto, Josep M., Bachert, Claus, Haahtela, Tari, Zuberbier, Torsten, Czarlewski, Wienczyslawa, Bedbrook, Anna, Bosnic-Anticevich, Sinthia, Walter Canonica, G., Cardona, Victoria, Costa, Elisio, Cruz, Alvaro A., Erhola, Marina, Fokkens, Wytske J., Fonseca, Joao A., Illario, Maddalena, Ivancevich, Juan Carlos, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Le, L. T.T., Larenas-Linnemann, Désirée E., Laune, Daniel, Lourenço, Olga M., Melén, Erik, Mullol, Joaquim, Niedoszytko, Marek, Odemyr, Mikaëla, Okamoto, Yoshitaka, Papadopoulos, Nikos G., Patella, Vincenzo, Pfaar, Oliver, Pham-Thi, Nhân, Rolland, Christine, Samolinski, Boleslaw, Sheikh, Aziz, Sofiev, Mikhail, Suppli Ulrik, Charlotte, Todo-Bom, Ana, Tomazic, Peter Valentin, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valiulis, Arunas, Valovirta, Erkka, Ventura, Maria Teresa, Walker, Samantha, Williams, Sian, Yorgancioglu, Arzu, Agache, Ioana, Akdis, Cezmi A., Almeida, Rute, Ansotegui, Ignacio J., Annesi-Maesano, Isabella, Arnavielhe, Sylvie, Basagaña, Xavier, D. Bateman, Eric, Bédard, Annabelle, Bedolla-Barajas, Martin, Becker, Sven, Bennoor, Kazi S., Benveniste, Samuel, Bergmann, Karl C., Bewick, Michael, Bialek, Slawomir, E. Billo, Nils, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Bonini, Matteo, Bonniaud, Philippe, Bosse, Isabelle, Bouchard, Jacques, Boulet, Louis Philippe, Bourret, Rodolphe, Boussery, Koen, Braido, Fluvio, Briedis, Vitalis, Briggs, Andrew, Brightling, Christopher E., Brozek, Jan, Brusselle, Guy, Brussino, Luisa, Buhl, Roland, Buonaiuto, Roland, Calderon, Moises A., Camargos, Paulo, Camuzat, Thierry, Caraballo, Luis, Carriazo, Ana Maria, Carr, Warner, Cartier, Christine, Casale, Thomas, Cecchi, Lorenzo, Cepeda Sarabia, Alfonso M., H. Chavannes, Niels, Chkhartishvili, Ekaterine, Chu, Derek K., Cingi, Cemal, Correia de Sousa, Jaime, Costa, David J., Courbis, Anne Lise, Custovic, Adnan, Cvetkosvki, Biljana, D'Amato, Gennaro, da Silva, Jane, Dantas, Carina, Dokic, Dejan, Dauvilliers, Yves, De Feo, Giulia, De Vries, Govert, Devillier, Philippe, Di Capua, Stefania, Dray, Gerard, Dubakiene, Ruta, Durham, Stephen R., Dykewicz, Marc, Ebisawa, Motohiro, Gaga, Mina, El-Gamal, Yehia, Heffler, Enrico, Emuzyte, Regina, Farrell, John, Fauquert, Jean Luc, Fiocchi, Alessandro, Fink-Wagner, Antje, Fontaine, Jean François, Fuentes Perez, José M., Gemicioğlu, Bilun, Gamkrelidze, Amiran, Garcia-Aymerich, Judith, Gevaert, Philippe, Gomez, René Maximiliano, González Diaz, Sandra, Gotua, Maia, Guldemond, Nick A., Guzmán, Maria Antonieta, Hajjam, Jawad, Huerta Villalobos, Yunuen R., Humbert, Marc, Iaccarino, Guido, Ierodiakonou, Despo, Iinuma, Tomohisa, Jassem, Ewa, Joos, Guy, Jung, Ki Suck, Kaidashev, Igor, Kalayci, Omer, Kardas, Przemyslaw, Keil, Thomas, Khaitov, Musa, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Kouznetsov, Rostislav, Kowalski, Marek L., Kritikos, Vicky, Kull, Inger, La Grutta, Stefania, Leonardini, Lisa, Ljungberg, Henrik, Lieberman, Philip, Lipworth, Brian, Lodrup Carlsen, Karin C., Lopes-Pereira, Catarina, Loureiro, Claudia C., Louis, Renaud, Mair, Alpana, Mahboub, Bassam, Makris, Michaël, Malva, Joao, Manning, Patrick, Marshall, Gailen D., Masjedi, Mohamed R., Maspero, Jorge F., Carreiro-Martins, Pedro, Makela, Mika, Mathieu-Dupas, Eve, Maurer, Marcus, De Manuel Keenoy, Esteban, Melo-Gomes, Elisabete, Meltzer, Eli O., Menditto, Enrica, Mercier, Jacques, Micheli, Yann, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Mitsias, Dimitirios I., Moda, Giuliana, Mogica-Martinez, Maria Dolores, Mohammad, Yousser, Montefort, Steve, Monti, Ricardo, Morais-Almeida, Mario, Mösges, Ralph, Münter, Lars, Muraro, Antonella, Murray, Ruth, Naclerio, Robert, Napoli, Luigi, Namazova-Baranova, Leyla, Neffen, Hugo, Nekam, Kristoff, Neou, Angelo, Nordlund, Björn, Novellino, Ettore, Nyembue, Dieudonné, O'Hehir, Robyn, Ohta, Ken, Okubo, Kimi, Onorato, Gabrielle L., Orlando, Valentina, Ouedraogo, Solange, Palamarchuk, Julia, Pali-Schöll, Isabella, Panzner, Peter, Park, Hae Sim, Passalacqua, Gianni, Pépin, Jean Louis, Paulino, Ema, Pawankar, Ruby, Phillips, Jim, Picard, Robert, Pinnock, Hilary, Plavec, Davor, Popov, Todor A., Portejoie, Fabienne, Price, David, Prokopakis, Emmanuel P., Psarros, Fotis, Pugin, Benoit, Puggioni, Francesca, Quinones-Delgado, Pablo, Raciborski, Filip, Rajabian-Söderlund, Rojin, Regateiro, Frederico S., Reitsma, Sietze, Rivero-Yeverino, Daniela, Roberts, Graham, Roche, Nicolas, Rodriguez-Zagal, Erendira, Roller-Wirnsberger, Regina E., Rosario, Nelson, Romano, Antonino, Rottem, Menachem, Ryan, Dermot, Salimäki, Johanna, Sanchez-Borges, Mario M., Sastre, Joaquin, Scadding, Glenis K., Scheire, Sophie, Schmid-Grendelmeier, Peter, Schünemann, Holger J., Sarquis Serpa, Faradiba, Shamji, Mohamed, Sisul, Juan Carlos, Solé, Dirceu, Somekh, David, Sooronbaev, Talant, Sova, Milan, Spertini, François, Spranger, Otto, Stellato, Cristiana, Stelmach, Rafael, Thibaudon, Michel, To, Teresa, Toumi, Mondher, Usmani, Omar, Valero, Antonio A., Valenta, Rudolph, Valentin-Rostan, Marylin, Pereira, Marilyn Urrutia, van der Kleij, Rianne, Van Eerd, Michiel, Vandenplas, Olivier, Vasankari, Tuula, Vaz Carneiro, Antonio, Vezzani, Giorgio, Viart, Frédéric, Viegi, Giovanni, Wallace, Dana, Wagenmann, Martin, Wang, De Yun, Waserman, Susan, Wickman, Magnus, Williams, Dennis M., Wong, Gary, Wroczynski, Piotr, Yiallouros, Panayiotis K., Yusuf, Osman M., Zar, Heather J., Zeng, Stéphane, Zernotti, Mario E., Zhang, Luo, Shan Zhong, Nan, Zidarn, Mihaela, and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

Subjects
ARIA, rhinitis, CARAT, MASK, Immunology, Immunology and Allergy, asthma, digital transformation of health and care
Abstract

Funding: MA reports personal fees from POCI-01-0145-FEDER-029130 mINSPIRERS—mHealth to measure and improve adherence to medication in chronic obstructive respiratory diseases—generalization and evaluation of gamification, peer support and advanced image processing technologies from ERDF (European Regional Development Fund) funded by the COMPETE2020 and by National Funds through FCT (Fundação para a Ciência e a Tecnologia)… Digital anamorphosis is used to define a distorted image of health and care that may be viewed correctly using digital tools and strategies. MASK digital anamorphosis represents the process used by MASK to develop the digital transformation of health and care in rhinitis. It strengthens the ARIA change management strategy in the prevention and management of airway disease. The MASK strategy is based on validated digital tools. Using the MASK digital tool and the CARAT online enhanced clinical framework, solutions for practical steps of digital enhancement of care are proposed. publishersversion published

Published
2021

16. ARIA digital anamorphosis: Digital transformation of health and care in airway diseases from research to practice

Author

Bousquet, Jean Anto, Josep M. Bachert, Claus Haahtela, Tari and Zuberbier, Torsten Czarlewski, Wienczyslawa Bedbrook, Anna and Bosnic-Anticevich, Sinthia Walter Canonica, G. Cardona, Victoria Costa, Elisio Cruz, Alvaro A. Erhola, Marina and Fokkens, Wytske J. Fonseca, Joao A. Illario, Maddalena and Ivancevich, Juan-Carlos Jutel, Marek Klimek, Ludger Kuna, Piotr Kvedariene, Violeta Le, L. T. T. Larenas-Linnemann, Desiree E. Laune, Daniel Lourenco, Olga M. Melen, Erik and Mullol, Joaquim Niedoszytko, Marek Odemyr, Mikaela Okamoto, Yoshitaka Papadopoulos, Nikos G. Patella, Vincenzo Pfaar, Oliver Pham-Thi, Nhan Rolland, Christine Samolinski, Boleslaw Sheikh, Aziz Sofiev, Mikhail Suppli Ulrik, Charlotte Todo-Bom, Ana Tomazic, Peter-Valentin and Toppila-Salmi, Sanna Tsiligianni, Ioanna Valiulis, Arunas and Valovirta, Erkka Ventura, Maria-Teresa Walker, Samantha and Williams, Sian Yorgancioglu, Arzu Agache, Ioana Akdis, Cezmi A. Almeida, Rute Ansotegui, Ignacio J. Annesi-Maesano, Isabella Arnavielhe, Sylvie Basagana, Xavier D. Bateman, Eric Bedard, Annabelle Bedolla-Barajas, Martin Becker, Sven and Bennoor, Kazi S. Benveniste, Samuel Bergmann, Karl C. and Bewick, Michael Bialek, Slawomir E. Billo, Nils and Bindslev-Jensen, Carsten Bjermer, Leif Blain, Hubert Bonini, Matteo Bonniaud, Philippe Bosse, Isabelle Bouchard, Jacques and Boulet, Louis-Philippe Bourret, Rodolphe Boussery, Koen and Braido, Fluvio Briedis, Vitalis Briggs, Andrew Brightling, Christopher E. Brozek, Jan Brusselle, Guy Brussino, Luisa and Buhl, Roland Buonaiuto, Roland Calderon, Moises A. and Camargos, Paulo Camuzat, Thierry Caraballo, Luis Carriazo, Ana-Maria Carr, Warner Cartier, Christine Casale, Thomas and Cecchi, Lorenzo Cepeda Sarabia, Alfonso M. H. Chavannes, Niels and Chkhartishvili, Ekaterine Chu, Derek K. Cingi, Cemal and Correia de Sousa, Jaime Costa, David J. Courbis, Anne-Lise and Custovic, Adnan Cvetkosvki, Biljana D'Amato, Gennaro da Silva, Jane Dantas, Carina Dokic, Dejan Dauvilliers, Yves and De Feo, Giulia De Vries, Govert Devillier, Philippe Di Capua, Stefania Dray, Gerard Dubakiene, Ruta Durham, Stephen R. Dykewicz, Marc Ebisawa, Motohiro Gaga, Mina El-Gamal, Yehia Heffler, Enrico Emuzyte, Regina Farrell, John and Fauquert, Jean-Luc Fiocchi, Alessandro Fink-Wagner, Antje and Fontaine, Jean-Francois Fuentes Perez, Jose M. Gemicioglu, Bilun and Gamkrelidze, Amiran Garcia-Aymerich, Judith Gevaert, Philippe Gomez, Rene Maximiliano Gonzalez Diaz, Sandra and Gotua, Maia Guldemond, Nick A. Guzman, Maria-Antonieta and Hajjam, Jawad Huerta Villalobos, Yunuen R. Humbert, Marc and Iaccarino, Guido Ierodiakonou, Despo Iinuma, Tomohisa and Jassem, Ewa Joos, Guy Jung, Ki-Suck Kaidashev, Igor and Kalayci, Omer Kardas, Przemyslaw Keil, Thomas Khaitov, Musa and Khaltaev, Nikolai Kleine-Tebbe, Jorg Kouznetsov, Rostislav and Kowalski, Marek L. Kritikos, Vicky Kull, Inger La Grutta, Stefania Leonardini, Lisa Ljungberg, Henrik and Lieberman, Philip Lipworth, Brian Lodrup Carlsen, Karin C. and Lopes-Pereira, Catarina Loureiro, Claudia C. Louis, Renaud and Mair, Alpana Mahboub, Bassam Makris, Michael Malva, Joao and Manning, Patrick Marshall, Gailen D. Masjedi, Mohamed R. and Maspero, Jorge F. Carreiro-Martins, Pedro Makela, Mika and Mathieu-Dupas, Eve Maurer, Marcus De Manuel Keenoy, Esteban and Melo-Gomes, Elisabete Meltzer, Eli O. Menditto, Enrica and Mercier, Jacques Micheli, Yann Miculinic, Neven Mihaltan, Florin Milenkovic, Branislava Mitsias, Dimitirios I. Moda, Giuliana Mogica-Martinez, Maria-Dolores Mohammad, Yousser and Montefort, Steve Monti, Ricardo Morais-Almeida, Mario and Mosges, Ralph Munter, Lars Muraro, Antonella Murray, Ruth and Naclerio, Robert Napoli, Luigi Namazova-Baranova, Leyla and Neffen, Hugo Nekam, Kristoff Neou, Angelo Nordlund, Bjorn and Novellino, Ettore Nyembue, Dieudonne O'Hehir, Robyn and Ohta, Ken Okubo, Kimi Onorato, Gabrielle L. Orlando, Valentina Ouedraogo, Solange Palamarchuk, Julia Pali-Scholl, Isabella Panzner, Peter Park, Hae-Sim Passalacqua, Gianni and Pepin, Jean-Louis Paulino, Ema Pawankar, Ruby Phillips, Jim Picard, Robert Pinnock, Hilary Plavec, Davor Popov, Todor A. Portejoie, Fabienne Price, David Prokopakis, Emmanuel P. Psarros, Fotis Pugin, Benoit Puggioni, Francesca and Quinones-Delgado, Pablo Raciborski, Filip and Rajabian-Soderlund, Rojin Regateiro, Frederico S. Reitsma, Sietze Rivero-Yeverino, Daniela Roberts, Graham Roche, Nicolas Rodriguez-Zagal, Erendira Rolland, Christine and Roller-Wirnsberger, Regina E. Rosario, Nelson Romano, Antonino and Rottem, Menachem Ryan, Dermot Salimaki, Johanna and Sanchez-Borges, Mario M. Sastre, Joaquin Scadding, Glenis K. and Scheire, Sophie Schmid-Grendelmeier, Peter Schunemann, Holger J. and Sarquis Serpa, Faradiba Shamji, Mohamed Sisul, Juan-Carlos and Sofiev, Mikhail Sole, Dirceu Somekh, David Sooronbaev, Talant Sova, Milan Spertini Spranger, Otto Stellato, Cristiana Stelmach, Rafael Thibaudon, Michel To, Teresa and Toumi, Mondher Usmani, Omar Valero, Antonio A. Valenta, Rudolph Valentin-Rostan, Marylin Pereira, Marilyn Urrutia and van der Kleij, Rianne Van Eerd, Michiel Vandenplas, Olivier and Vasankari, Tuula Vaz Carneiro, Antonio Vezzani, Giorgio and Viart, Frederic Viegi, Giovanni Wallace, Dana Wagenmann, Martin Wang, De Yun Waserman, Susan Wickman, Magnus and Williams, Dennis M. Wong, Gary Wroczynski, Piotr Yiallouros, Panayiotis K. Yusuf, Osman M. Zar, Heather J. Zeng, Stephane and Zernotti, Mario E. Zhang, Luo Shan Zhong, Nan Zidarn, Mihaela

Abstract

Digital anamorphosis is used to define a distorted image of health and care that may be viewed correctly using digital tools and strategies. MASK digital anamorphosis represents the process used by MASK to develop the digital transformation of health and care in rhinitis. It strengthens the ARIA change management strategy in the prevention and management of airway disease. The MASK strategy is based on validated digital tools. Using the MASK digital tool and the CARAT online enhanced clinical framework, solutions for practical steps of digital enhancement of care are proposed.

Published
2021

17. Rethinking palliative care in a public health context: addressing the needs of persons with non-communicable chronic diseases - CORRIGENDUM

Author

Tziraki, Chariklia, Grimes, Corrina, Ventura, Filipa, O'Caoimh, Ronan, Santana, Silvina, Zavagli, Veronica, Varani, Silvia, Tramontano, Donatella, Apóstolo, João, Geurden, Bart, Luca, Vincenzo de, Tramontano, Giovanni, Romano, Maria Rosaria, Anastasaki, Marilena, Lionis, Christos, Rodríguez-Acuña, Rafael, Capelas, Manuel Luís, Afonso, Tânia dos Santos, Molloy, D. William, Liotta, Giuseppe, Iaccarino, Guido, Triassi, Maria, Eklund, Patrik, Roller-Wirnsberger, Regina, Illario, Maddalena, Tziraki, C., Grimes, C., Ventura, F., O'Caoimh, R., Santana, S., Zavagli, V., Varani, S., Tramontano, D., Apostolo, J., Geurden, B., De Luca, V., Tramontano, G., Rosaria Romano, M., Anastasaki, M., Lionis, C., Rodriguez-Acuna, R., Capelas, M. L., Dos Santos Afonso, T., William Molloy, D., Liotta, G., Iaccarino, G., Triassi, M., Eklund, P., Roller-Wirnsberger, R., Illario, M., and Veritati - Repositório Institucional da Universidade Católica Portuguesa

Subjects
palliative care, multimorbidity, public health, Public Health, Environmental and Occupational Health, Development, integrated, non-communicable chronic diseases (NCCDs), Care Planning
Abstract

Non-communicable chronic diseases (NCCDs) are the main cause of morbidity and mortality globally. Demographic aging has resulted in older populations with more complex healthcare needs. This necessitates a multilevel rethinking of healthcare policies, health education and community support systems with digitalization of technologies playing a central role. The European Innovation Partnership on Active and Healthy Aging (A3) working group focuses on well-being for older adults, with an emphasis on quality of life and healthy aging. A subgroup of A3, including multidisciplinary stakeholders in health care across Europe, focuses on the palliative care (PC) model as a paradigm to be modified to meet the needs of older persons with NCCDs. This development paper delineates the key parameters we identified as critical in creating a public health model of PC directed to the needs of persons with NCCDs. This paradigm shift should affect horizontal components of public health models. Furthermore, our model includes vertical components often neglected, such as nutrition, resilience, well-being and leisure activities. The main enablers identified are information and communication technologies, education and training programs, communities of compassion, twinning activities, promoting research and increasing awareness amongst policymakers. We also identified key ‘bottlenecks’: inequity of access, insufficient research, inadequate development of advance care planning and a lack of co-creation of relevant technologies and shared decision-making. Rethinking PC within a public health context must focus on developing policies, training and technologies to enhance person-centered quality life for those with NCCD, while ensuring that they and those important to them experience death with dignity.

Published
2020

18. Next-generation ARIA care pathways for rhinitis and asthma: a model for multimorbid chronic diseases

Author

Bousquet, J Jean, Schünemann, Holger J, Togias, Alkis, Erhola, Marina, Hellings, Peter W, Zuberbier, Torsten, Agache, Ioana, Ansotegui, Ignacio J, Anto, Josep M, Bachert, Claus, Becker, Sven, Bedolla-Barajas, Martin, Bewick, Michael, Bosnic-Anticevich, Sinthia, Bosse, Isabelle, Boulet, Louis P, Bourrez, Jean Marc, Brusselle, Guy, Chavannes, Niels, Costa, Elisio, Cruz, Alvaro A, Czarlewski, Wienczyslawa, Fokkens, Wytske J, Fonseca, Joao A, Gaga, Mina, Haahtela, Tari, Illario, Maddalena, Klimek, Ludger, Kuna, Piotr, et al, University of Zurich, and Bousquet, J Jean

Subjects
2403 Immunology, ARIA, MASK, 10183 Swiss Institute of Allergy and Asthma Research, 2740 Pulmonary and Respiratory Medicine, Care pathways, Health care transformation, 2723 Immunology and Allergy, 610 Medicine & health, POLLAR, Rhinitis
Published
2019

19. Interactions Between EIP on AHA Reference Sites and Action Groups to Foster Digital Innovation of Health and Care in European Regions.

Author

Illario, Maddalena, De Luca, Vincenzo, Onorato, Gabrielle, Tramontano, Giovanni, Carriazo, Ana Maria, Roller-Wirnsberger, Regina Elisabeth, Apostolo, Joao, Eklund, Patrik, Goswami, Nandu, Iaccarino, Guido, Triassi, Maria, Farrell, John, and Bousquet, Jean

Subjects
DIGITAL health, ACTIVE aging, MEDICAL care, COLLECTIVE action, INFORMATION sharing
Abstract

The article describes some of the achievements of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA), after eight years in operation. These results were achieved thanks to the collaborative work of the action groups (AGs) and reference sites (RSs). RS regional ecosystems include key organisations committed to investing in innovation to foster active and healthy ageing. The AGs are groups of professionals committed to sharing their knowledge and skills in active and healthy ageing. This article reports on the approach used by the EIP on AHA to bring together experts and regions in identifying and addressing these challenges. Synergies between AGs offered substantial support to RSs, allowing regional health and care priorities and challenges to be identified and pursued through AG commitments. Building upon the experiences of the EIP on AHA, the Reference Sites Collaborative Network has set up a number of thematic action groups that bring together multidisciplinary experts from across Europe to address the main health and social care challenges at regional, national and European level. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
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20. Chefs in Future Integrated Healthcare -- Current State and Innovation Needs: A First Overview of the NECTAR Project (aN Eu Curriculum for Chef gasTro-Engineering in Primary Food Care).

Author

WINTERS, MARJOLEIN, WAGNER, VALENTINA, PATALANO, ROBERTA, LINDNER, SONJA, ALVINO, SERENA, ROLLER-WIRNSBERGER, REGINA, MÜLLER-RIEDLHUBER, HEIDEMARIE, PAIS, SANDRA, BORRIELLO, MATILDE, FARREL, JOHN, VLAEMYNCK, GEERTRUI, VAN GEMST, MARTIJN, GEURDEN, BART, DEN WIJNGAERT, LOBKE VAN, GOOSSENS, EDWIG, ILLARIO, MADDALENA, and HERZOG, CAROLIN

Subjects
INTEGRATED health care delivery, NECTAR, NUTRITIONAL requirements, COOKS, FOOD consumption, INTERPROFESSIONAL education
Abstract

People in need of care, chronic or acute, often present problematic food intake and special nutritional needs. Integrated, person-centred and pro-active food and nutritional care delivery has been proven effective for people in health care. However, skills mismatches have been reported in different professions involved, which also applies to the role of chefs in healthcare. The EU funded project NECTAR aims at closing this gap by creating a new job profile, called Chef Gastro-Engineering (CGE). The current publication summarizes the status quo in hospitals and gives a perspective on the future role of chefs in integrated healthcare delivery. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

21. ARIA pharmacy 2018: Allergic rhinitis care pathways for community pharmacy

Author

Bosnic-Anticevich, Sinthia, Costa, Elísio, Menditto, Enrica, Lourenço, Olga, Novellino, Ettore, Bialek, Slawomir, Briedis, Vitalis, Buonaiuto, Roland, Chrystyn, Henry, Cvetkovski, Biljana, Di Capua, Stefania, Sousa, Jaime Correia de, De Carlo, Giuseppe, Demoly, Pascal, Devillier, Philippe, Dykewicz, Mark S, Gaga, Mina, El-Gamal, Yehia, Fonseca, João, Fokkens, Wytske J, Kuna, Piotr, Kowalski, Marek, Guzmán, Maria Antonieta, Haahtela, Tari, Hellings, Peter W, Illario, Maddalena, Ivancevich, Juan Carlos, Just, Jocelyne, Kaidashev, Igor, Khaitov, Musa, Khaltaev, Nikolai, Keil, Thomas, Larenas-Linnemann, Désirée, Kvedariene, Violeta, Klimek, Ludger, Laune, Daniel, Le, Lan T T, Lodrup Carlsen, Karin C, Mahboub, Bassam, Maier, Dieter, Malva, João, Manning, Patrick J, Okamoto, Yoshitaka, Ohta, Ken, Almeida, Mário Morais, Mösges, Ralph, Mullol, Joaquim, Münter, Lars, Murray, Ruth, Naclerio, Robert, Namazova-Baranova, Leyla, Nekam, Kristof, Nyembue, Tshipukane Dieudonné, Okubo, Kimi, Palkonen, Susanna, Onorato, Gabrielle L, O'Hehir, Robyn E, Panzner, Petr, Papadopoulos, Nikolaos G, Park, Hae-Sim, Pawankar, Ruby, Pfaar, Oliver, Phillips, Jim, Plavec, Davor, Stellato, Cristiana, Somekh, David, Popov, Todor A, Potter, Paul C, Prokopakis, Emmanuel P, Roller-Wirnsberger, Regina E, Rottem, Menachem, Ryan, Dermot, Samolinski, Boleslaw, Sanchez-Borges, Mario, Schunemann, Holger J, Sheikh, Aziz, Todo-Bom, Ana Maria, To, Teresa, Sisul, Juan Carlos, Tomazic, Peter Valentin, Toppila-Salmi, Sanna, Valero, Antonio, Valiulis, Arunas, Valovirta, Errka, Ventura, Maria Teresa, Wagenmann, Martin, Kritikos, Vicky, Bousquet, Jean, Wallace, Dana, Waserman, Susan, Wickman, Magnus, Yiallouros, Panayiotis K, Yorgancioglu, Arzu, Yusuf, Osman M, Zar, Heather J, Zernotti, Mario E, Zhang, Luo, Zidarn, Mihaela, Orlando, Valentina, Mair, Alpana, Zuberbier, Torsten, Paulino, Ema, Salimäki, Johanna, Söderlund, Rojin, Tan, Rachel, Williams, Dennis M, Wroczynski, Piotr, Agache, Ioana, Ansotegui, Ignacio J, Cruz, Alvaro A, Anto, Josep M, Bedbrook, Anna, Bachert, Claus, Bewick, Mike, Bindslev-Jensen, Carsten, Brozek, Jan L, Canonica, Giorgio Walter, Cardona, Victoria, Carr, Warner, Casale, Thomas, Czarlewski, Wienczyslawa, Chavannes, Niels H, and uBibliorum

Subjects
Care pathways, Pharmacist, Allergic Rhinitis and its Impact on Asthma, Asthma, Rhinitis
Abstract

Pharmacists are trusted health care professionals. Many patients use over-the-counter (OTC) medications and are seen by pharmacists who are the initial point of contact for allergic rhinitis management in most countries. The role of pharmacists in integrated care pathways (ICPs) for allergic diseases is important. This paper builds on existing studies and provides tools intended to help pharmacists provide optimal advice/interventions/strategies to patients with rhinitis. The Allergic Rhinitis and its Impact on Asthma (ARIA)-pharmacy ICP includes a diagnostic questionnaire specifically focusing attention on key symptoms and markers of the disease, a systematic Diagnosis Guide (including differential diagnoses), and a simple flowchart with proposed treatment for rhinitis and asthma multimorbidity. Key prompts for referral within the ICP are included. The use of technology is critical to enhance the management of allergic rhinitis. However, the ARIA-pharmacy ICP should be adapted to local healthcare environments/situations as regional (national) differences exist in pharmacy care.

Published
2019

23. Next-generation ARIA care pathways for rhinitis and asthma: a model for multimorbid chronic diseases: Review

Author

Schünemann, Holger J., Yiallouros, Panayiotis K., Bousquet, J. Jean, Togias, Alkis, Erhola, Marina, Hellings, Peter W., Zuberbier, Torsten, Agache, Ioana, Ansotegui, Ignacio J., Anto, Josep M., Bachert, Claus, Becker, Sven, Bedolla-Barajas, Martin, Bewick, Michael, Bosnic-Anticevich, Sinthia, Bosse, Isabelle, Boulet, Louis P., Bourrez, Jean Marc, Brusselle, Guy, Chavannes, Niels, Costa, Elisio, Cruz, Alvaro A., Czarlewski, Wienczyslawa, Fokkens, Wytske J., Fonseca, Joao A., Gaga, Mina, Haahtela, Tari, Illario, Maddalena, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Le, L. T. T., Larenas-Linnemann, Desiree, Laune, Daniel, Lourenço, Olga M., Menditto, Enrica, Mullol, Joaquin, Okamoto, Yashitaka, Papadopoulos, Nikos, Pham-Thi, Nhân, Picard, Robert, Pinnock, Hilary, Roche, Nicolas, Roller-Wirnsberger, Regina E., Rolland, Christine, Samolinski, Boleslaw, Sheikh, Aziz, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valiulis, Arunas, Valovirta, Erkka, Vasankari, Tuula, Ventura, Maria-Teresa, Walker, Samantha, Williams, Sian, Akdis, Cezmi A., Annesi-Maesano, Isabella, Arnavielhe, Sylvie, Basagana, Xavier, Bateman, Eric, Bedbrook, Anna, Bennoor, K. S., Benveniste, Samuel, Bergmann, Karl C., Bialek, Slawomir, Billo, Nils, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Bonini, Mateo, Bonniaud, Philippe, Bouchard, Jacques, Briedis, Vitalis, Brightling, Christofer E., Brozek, Jan, Buhl, Roland, Buonaiuto, Roland, Canonica, Giorgo W., Cardona, Victoria, Carriazo, Ana M., Carr, Warner, Cartier, Christine, Casale, Thomas, Cecchi, Lorenzo, Cepeda Sarabia, Alfonso M., Chkhartishvili, Eka, Chu, Derek K., Cingi, Cemal, Colgan, Elaine, de Sousa, Jaime Correia, Courbis, Anne Lise, Custovic, Adnan, Cvetkosvki, Biljana, D’Amato, Gennaro, da Silva, Jane, Dantas, Carina, Dokic, Dejand, Dauvilliers, Yves, Dedeu, Antoni, De Feo, Giulia, Devillier, Philippe, Di Capua, Stefania, Dykewickz, Marc, Dubakiene, Ruta, Ebisawa, Motohiro, El-Gamal, Yaya, Eller, Esben, Emuzyte, Regina, Farrell, John, Fink-Wagner, Antjie, Fiocchi, Alessandro, Fontaine, Jean F., Gemicioğlu, Bilun, Schmid-Grendelmeir, Peter, Gamkrelidze, Amiran, Garcia-Aymerich, Judith, Gomez, Maximiliano, González Diaz, Sandra, Gotua, Maia, Guldemond, Nick A., Guzmán, Maria-Antonieta, Hajjam, Jawad, O’B Hourihane, John, Humbert, Marc, Iaccarino, Guido, Ierodiakonou, Despo, Ivancevich, Juan C., Joos, Guy, Jung, Ki-Suck, Jutel, Marek, Kaidashev, Igor, Kalayci, Omer, Kardas, Przemyslaw, Keil, Thomas, Khaitov, Mussa, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Kowalski, Marek L., Kritikos, Vicky, Kull, Inger, Leonardini, Lisa, Lieberman, Philip, Lipworth, Brian, Lodrup Carlsen, Karin C., Loureiro, Claudia C., Louis, Renaud, Mair, Alpana, Marien, Gert, Mahboub, Bassam, Malva, Joao, Manning, Patrick, De Manuel Keenoy, Esteban, Marshall, Gailen D., Masjedi, Mohamed R., Maspero, Jorge F., Mathieu-Dupas, Eve, Matricardi, Poalo M., Melén, Eric, Melo-Gomes, Elisabete, Meltzer, Eli O., Mercier, Jacques, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Moda, Giuliana, Mogica-Martinez, Maria-Dolores, Mohammad, Yousser, Montefort, Steve, Monti, Ricardo, Morais-Almeida, Mario, Mösges, Ralf, Münter, Lars, Muraro, Antonella, Murray, Ruth, Naclerio, Robert, Napoli, Luigi, Namazova-Baranova, Leila, Neffen, Hugo, Nekam, Kristoff, Neou, Angelo, Novellino, Enrico, Nyembue, Dieudonné, O’Hehir, Robin, Ohta, Ken, Okubo, Kimi, Onorato, Gabrielle, Ouedraogo, Solange, Pali-Schöll, Isabella, Palkonen, Susanna, Panzner, Peter, Park, Hae-Sim, Pépin, Jean-Louis, Pereira, Ana-Maria, Pfaar, Oliver, Paulino, Ema, Phillips, Jim, Plavec, Davor, Popov, Ted A., Portejoie, Fabienne, Price, David, Prokopakis, Emmanuel P., Pugin, Benoit, Raciborski, Filip, Rajabian-Söderlund, Rojin, Reitsma, Sietze, Rodo, Xavier, Romano, Antonino, Rosario, Nelson, Rottem, Menahenm, Ryan, Dermot, Salimäki, Johanna, Sanchez-Borges, Mario M., Sisul, Juan-Carlos, Solé, Dirceu, Somekh, David, Sooronbaev, Talant, Sova, Milan, Spranger, Otto, Stellato, Cristina, Stelmach, Rafael, Suppli Ulrik, Charlotte, Thibaudon, Michel, To, Teresa, Todo-Bom, Ana, Tomazic, Peter V., Valero, Antonio A., Valenta, Rudolph, Valentin-Rostan, Marylin, van der Kleij, Rianne, Vandenplas, Olivier, Vezzani, Giorgio, Viart, Frédéric, Viegi, Giovanni, Wallace, Dana, Wagenmann, Martin, Wang, De Y., Waserman, Susan, Wickman, Magnus, Williams, Dennis M., Wong, Gary, Wroczynski, Piotr, Yorgancioglu, Arzu, Yusuf, Osman M., Zar, Heahter J., Zeng, Stéphane, Zernotti, Mario, Zhang, Luo, Zhong, Nan S., Zidarn, Mihaela, Bousquet, J., Hellings, P. W., Aberer, W., Agache, I., Akdis, C. A., Akdis, M., Aliberti, M. R., Almeida, R., Amat, F., Angles, R., Annesi-Maesano, I., Ansotegui, I. J., Anto, J. M., Arnavielle, S., Asayag, E., Asarnoj, A., Arshad, H., Avolio, F., Bacci, E., Bachert, C., Baiardini, I., Barbara, C., Barbagallo, M., Baroni, I., Barreto, B. A., Basagana, X., Bateman, E. D., Bedolla-Barajas, M., Bedbrook, A., Bewick, M., Beghé, B., Bel, E. H., Bergmann, K. C., Benson, M., Bertorello, L., Białoszewski, A. Z., Bieber, T., Bialek, S., Bindslev-Jensen, C., Bjermer, L., Blain, H., Blasi, F., Blua, A., Bochenska Marciniak, M., Bogus-Buczynska, I., the ARIA Study Group, the MASK Study Group, Briedis, Vitalis, uBibliorum, Yiallouros, Panayiotis K. [0000-0002-8339-9285], Costa, Elisio [0000-0003-1158-1480], Kritikos, Vicky [0000-0003-3955-0002], Gaga, Mina [0000-0002-9949-6012], Prokopakis, Emmanuel P. [0000-0002-1208-1990], Togias, Alkis [0000-0001-9009-5717], Erhola, Marina [0000-0002-1364-9023], Bosnic-Anticevich, Sinthia [0000-0001-5077-8329], Lourenço, Olga M. [0000-0002-8401-5976], Ierodiakonou, Despo [0000-0002-7862-2016], Health Services Management & Organisation (HSMO), Obstetrics & Gynecology, Universidade do Minho, Laboratoire de Génie Informatique et Ingénierie de Production (LGI2P), IMT - MINES ALES (IMT - MINES ALES), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Bousquet, J. J., Schunemann, H. J., Togias, A., Erhola, M., Hellings, P. W., Zuberbier, T., Agache, I., Ansotegui, I. J., Anto, J. M., Bachert, C., Becker, S., Bedolla-Barajas, M., Bewick, M., Bosnic-Anticevich, S., Bosse, I., Boulet, L. P., Bourrez, J. M., Brusselle, G., Chavannes, N., Costa, E., Cruz, A. A., Czarlewski, W., Fokkens, W. J., Fonseca, J. A., Gaga, M., Haahtela, T., Illario, M., Klimek, L., Kuna, P., Kvedariene, V., Le, L. T. T., Larenas-Linnemann, D., Laune, D., Lourenco, O. M., Menditto, E., Mullol, J., Okamoto, Y., Papadopoulos, N., Pham-Thi, N., Picard, R., Pinnock, H., Roche, N., Roller-Wirnsberger, R. E., Rolland, C., Samolinski, B., Sheikh, A., Toppila-Salmi, S., Tsiligianni, I., Valiulis, A., Valovirta, E., Vasankari, T., Ventura, M. -T., Walker, S., Williams, S., Akdis, C. A., Annesi-Maesano, I., Arnavielhe, S., Basagana, X., Bateman, E., Bedbrook, A., Bennoor, K. S., Benveniste, S., Bergmann, K. C., Bialek, S., Billo, N., Bindslev-Jensen, C., Bjermer, L., Blain, H., Bonini, M., Bonniaud, P., Bouchard, J., Briedis, V., Brightling, C. E., Brozek, J., Buhl, R., Buonaiuto, R., Canonica, G. W., Cardona, V., Carriazo, A. M., Carr, W., Cartier, C., Casale, T., Cecchi, L., Cepeda Sarabia, A. M., Chkhartishvili, E., Chu, D. K., Cingi, C., Colgan, E., De Sousa, J. C., Courbis, A. L., Custovic, A., Cvetkosvki, B., Damato, G., Da Silva, J., Dantas, C., Dokic, D., Dauvilliers, Y., Dedeu, A., De Feo, G., Devillier, P., Di Capua, S., Dykewickz, M., Dubakiene, R., Ebisawa, M., El-Gamal, Y., Eller, E., Emuzyte, R., Farrell, J., Fink-Wagner, A., Fiocchi, A., Fontaine, J. F., Gemicioglu, B., Schmid-Grendelmeir, P., Gamkrelidze, A., Garcia-Aymerich, J., Gomez, M., Diaz, S. G., Gotua, M., Guldemond, N. A., Guzman, M. -A., Hajjam, J., O'Hourihane, J. B., Humbert, M., Iaccarino, G., Ierodiakonou, D., Ivancevich, J. C., Joos, G., Jung, K. -S., Jutel, M., Kaidashev, I., Kalayci, O., Kardas, P., Keil, T., Khaitov, M., Khaltaev, N., Kleine-Tebbe, J., Kowalski, M. L., Kritikos, V., Kull, I., Leonardini, L., Lieberman, P., Lipworth, B., Lodrup Carlsen, K. C., Loureiro, C. C., Louis, R., Mair, A., Marien, G., Mahboub, B., Malva, J., Manning, P., De Manuel Keenoy, E., Marshall, G. D., Masjedi, M. R., Maspero, J. F., Mathieu-Dupas, E., Matricardi, P. M., Melen, E., Melo-Gomes, E., Meltzer, E. O., Mercier, J., Miculinic, N., Mihaltan, F., Milenkovic, B., Moda, G., Mogica-Martinez, M. -D., Mohammad, Y., Montefort, S., Monti, R., Morais-Almeida, M., Mosges, R., Munter, L., Muraro, A., Murray, R., Naclerio, R., Napoli, L., Namazova-Baranova, L., Neffen, H., Nekam, K., Neou, A., Novellino, E., Nyembue, D., O'Hehir, R., Ohta, K., Okubo, K., Onorato, G., Ouedraogo, S., Pali-Scholl, I., Palkonen, S., Panzner, P., Park, H. -S., Pepin, J. -L., Pereira, A. -M., Pfaar, O., Paulino, E., Phillips, J., Plavec, D., Popov, T. A., Portejoie, F., Price, D., Prokopakis, E. P., Pugin, B., Raciborski, F., Rajabian-Soderlund, R., Reitsma, S., Rodo, X., Romano, A., Rosario, N., Rottem, M., Ryan, D., Salimaki, J., Sanchez-Borges, M. M., Sisul, J. -C., Sole, D., Somekh, D., Sooronbaev, T., Sova, M., Spranger, O., Stellato, C., Stelmach, R., Ulrik, C. S., Thibaudon, M., To, T., Todo-Bom, A., Tomazic, P. V., Valero, A. A., Valenta, R., Valentin-Rostan, M., Van Der Kleij, R., Vandenplas, O., Vezzani, G., Viart, F., Viegi, G., Wallace, D., Wagenmann, M., Wang, D. Y., Waserman, S., Wickman, M., Williams, D. M., Wong, G., Wroczynski, P., Yiallouros, P. K., Yorgancioglu, A., Yusuf, O. M., Zar, H. J., Zeng, S., Zernotti, M., Zhang, L., Zhong, N. S., Zidarn, M., UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, and UCL - (MGD) Service de pneumologie

Subjects
Allergy, IMPACT, Respiratory Medicine and Allergy, ARIA Study Group, Health care transformation, Care pathways, Rhinitis, ARIA, MASK, POLLAR, Review, GUIDELINES, Medical and Health Sciences, PATIENT-CARE, 0302 clinical medicine, immune system diseases, 11. Sustainability, Health care, Medicine and Health Sciences, Outras Ciências Médicas [Ciências Médicas], Immunology and Allergy, Medicine, 030212 general & internal medicine, mHealth, health care economics and organizations, Lungmedicin och allergi, Rhinitis, Self-management, 616.2 [udc], Environmental exposure, POLLAR, 3. Good health, CHRONIC RESPIRATORY-DISEASES, Care pathways, HEALTH, Life Sciences & Biomedicine, Pulmonary and Respiratory Medicine, SEASONAL ALLERGIC RHINITIS, medicine.medical_specialty, animal structures, MASK, Health care transformation, EUROPEAN INNOVATION PARTNERSHIP, ARIA, Immunology, Health literacy, 03 medical and health sciences, INTERMITTENT, BUDESONIDE-FORMOTEROL, As an example for chronic disease care, MASK (Mobile Airways Sentinel NetworK), a new project of the ARIA (Allergic Rhinitis and its Impact on Asthma) initiative, and POLLAR (Impact of Air POLLution on Asthma and Rhinitis, EIT Health), in collaboration with professional and patient organizations in the field of allergy and airway diseases, are proposing real-life ICPs centred around the patient with rhinitis, and using mHealth to monitor environmental exposure. Three aspects of care pathways are being developed: (i) Patient participation, health literacy and self-care through technology-assisted "patient activation", (ii) Implementation of care pathways by pharmacists and (iii) Next-generation guidelines assessing the recommendations of GRADE guidelines in rhinitis and asthma using real-world evidence (RWE) obtained through mobile technology. The EU and global political agendas are of great importance in supporting the digital transformation of health and care, and MASK has been recognized by DG Santé as a Good Practice in the field of digitally-enabled, integrated, person-centred care. Conclusion: In 20 years, ARIA has considerably evolved from the first multimorbidity guideline in respiratory diseases to the digital transformation of health and care with a strong political involvement, Air pollutants, adverse effects, Air pollution, Asthma, physiopathology, physiopathology [In all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support the transformation of the health care system into integrated care with organizational health literacy. Main body], Patient participation, SELF-MANAGEMENT, MASK Study Group, Ciências Médicas::Outras Ciências Médicas, udc:616.2, Care pathway, Science & Technology, business.industry, RC581-607, medicine.disease, respiratory tract diseases, Integrated care, 030228 respiratory system, 13. Climate action, Family medicine, Immunologic diseases. Allergy, Clinical Medicine, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

Background: In all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support the transformation of the health care system into integrated care with organizational health literacy. Main body: As an example for chronic disease care, MASK (Mobile Airways Sentinel NetworK), a new project of the ARIA (Allergic Rhinitis and its Impact on Asthma) initiative, and POLLAR (Impact of Air POLLution on Asthma and Rhinitis, EIT Health), in collaboration with professional and patient organizations in the field of allergy and airway diseases, are proposing real-life ICPs centred around the patient with rhinitis, and using mHealth to monitor environmental exposure. Three aspects of care pathways are being developed: (i) Patient participation, health literacy and self-care through technology-assisted “patient activation”, (ii) Implementation of care pathways by pharmacists and (iii) Next-generation guidelines assessing the recommendations of GRADE guidelines in rhinitis and asthma using real-world evidence (RWE) obtained through mobile technology. The EU and global political agendas are of great importance in supporting the digital transformation of health and care, and MASK has been recognized by DG Santé as a Good Practice in the field of digitally-enabled, integrated, person-centred care. Conclusion: In 20 years, ARIA has considerably evolved from the first multimorbidity guideline in respiratory diseases to the digital transformation of health and care with a strong political involvement., Partly funded by POLLAR (Impact of Air POLLution on Asthma and Rhinitis, EIT Health), and ARIA.

Published
2019

24. ARIA pharmacy 2018 'Allergic rhinitis care pathways for community pharmacy'

Author

Yiallouros, Panayiotis K., Larenas‐Linnemann, Désirée E., Bosnic‐Anticevich, Sinthia, Costa, Elisio, Menditto, Enrica, Lourenço, Olga, Novellino, Ettore, Bialek, Slawomir, Briedis, Vitalis, Buonaiuto, Roland, Chrystyn, Henry, Cvetkovski, Biljana, Capua, Stefania Di, Kritikos, Vicky, Mair, Alpana, Orlando, Valentina, Paulino, Ema, Salimäki, Johanna, Söderlund, Rojin, Tan, Rachel, Williams, Dennis M., Wroczynski, Piotr, Agache, Ioana, Ansotegui, Ignacio J., Anto, Josep M., Bedbrook, Anna, Bachert, Claus, Bewick, Mike, Bindslev‐Jensen, Carsten, Brozek, Jan L., Canonica, Giorgio Walter, Cardona, Victoria, Carr, Warner, Casale, Thomas B., Chavannes, Niels H., Sousa, Jaime Correia de, Cruz, Alvaro A., Czarlewski, Wienczyslawa, Carlo, Giuseppe De, Demoly, Pascal, Devillier, Philippe, Dykewicz, Mark S., Gaga, Mina, El‐Gamal, Yehia, Fonseca, João, Fokkens, Wytske J., Guzmán, Maria Antonieta, Haahtela, Tari, Hellings, Peter W., Illario, Maddalena, Ivancevich, Juan Carlos, Just, Jocelyne, Kaidashev, Igor, Khaitov, Musa, Khaltaev, Nikolai, Keil, Thomas, Klimek, Ludger, Kowalski, Marek L., Kuna, Piotr, Kvedariene, Violeta, Laune, Daniel, Le, Lan T. T., Carlsen, Karin C. Lodrup, Mahboub, Bassam, Maier, Dieter, Malva, Joao, Manning, Patrick J., Morais‐Almeida, Mário, Mösges, Ralph, Mullol, Joaquim, Münter, Lars, Murray, Ruth, Naclerio, Robert, Namazova‐Baranova, Leyla, Nekam, Kristof, Nyembue, Tshipukane Dieudonné, Okubo, Kimi, O'Hehir, Robyn E., Ohta, Ken, Okamoto, Yoshitaka, Onorato, Gabrielle L., Palkonen, Susanna, Panzner, Petr, Papadopoulos, Nikolaos G., Park, Hae-Sim, Pawankar, Ruby, Pfaar, Oliver, Phillips, Jim, Plavec, Davor, Popov, Todor A., Potter, Paul C., Prokopakis, Emmanuel P., Roller‐Wirnsberger, Regina E., Rottem, Menachem, Ryan, Dermot, Samolinski, Bolesław, Sanchez‐Borges, Mario, Schunemann, Holger J., Sheikh, Aziz, Sisul, Juan Carlos, Somekh, David, Stellato, Cristiana, To, Teresa, Todo‐Bom, Ana Maria, Tomazic, Peter Valentin, Toppila‐Salmi, Sanna, Valero, Antonio, Valiulis, Arunas, Valovirta, Errka, Ventura, Maria Teresa, Wagenmann, Martin, Wallace, Dana, Waserman, Susan, Wickman, Magnus, Yorgancioglu, Arzu, Yusuf, Osman M., Zar, Heather J., Zernotti, Mario E., Zhang, Luo, Zidarn, Mihaela, Zuberbier, Torsten, Bousquet, Jean, Yiallouros, Panayiotis K. [0000-0002-8339-9285], Costa, Elisio [0000-0003-1158-1480], Kritikos, Vicky [0000-0003-3955-0002], Gaga, Mina [0000-0002-9949-6012], Papadopoulos, Nikolaos G. [0000-0002-4448-3468], and Prokopakis, Emmanuel P. [0000-0002-1208-1990]

Abstract

Pharmacists are trusted health care professionals. Many patients use over-the-counter (OTC) medications and are seen by pharmacists who are the initial point of contact for allergic rhinitis management in most countries. The role of pharmacists in integrated care pathways (ICPs) for allergic diseases is important. This paper builds on existing studies and provides tools intended to help pharmacists provide optimal advice/interventions/strategies to patients with rhinitis. The Allergic Rhinitis and its Impact on Asthma (ARIA)-pharmacy ICP includes a diagnostic questionnaire specifically focusing attention on key symptoms and markers of the disease, a systematic Diagnosis Guide (including differential diagnoses), and a simple flowchart with proposed treatment for rhinitis and asthma multimorbidity. Key prompts for referral within the ICP are included. The use of technology is critical to enhance the management of allergic rhinitis. However, the ARIA-pharmacy ICP should be adapted to local healthcare environments/situations as regional (national) differences exist in pharmacy care. 74 7 1219 1236

Published
2019

25. Health tourism: an opportunity for sustainable development

Author

Illario, Maddalena, De Luca, Vincenzo, Leonardini, Lisa, Kucharczyk, Maciej, Parent, Anne-Sophie, Dantas, Carina, Jegundo, Ana Luísa, Van Staalduinen, Willeke, Ganzarain, Javier, Comisso, Leopoldo, Bramezza, Carlo, Carriazo, Ana Maria, Maritati, Antonio, Tramontano, Giovanni, Capozzi, Pierfrancesco, Goossens, Eva, Cotrone, Carmela, Costantini, Arianna, Ciliberti, Michela, Femiano, Maria, D’Amore, Antonio, Forlenza, Maria, Ruggiero, Rosa, Bianchi, Attilio, Augustin, Lua, Marrazzo, Vincenzo, Dello Ioio, Tristano, Capaldo, Steven J., Crudeli, Aurelio, De Cesare, Giovanni, Cuccaro, Fausta, Bracale, Giancarlo, Tramontano, Donatella, Postiglione, Amedeo, Matera, Camilla, Coscioni, Enrico, Bousquet, Jean, Illario, M, De Luca, V, Leonardini, L, Kucharczyk, M, Parent, A S, Dantas, C, Jegundo, A L, van Staalduinen, W, Ganzarain, J, Comisso, L, Bramezza, C, Carriazo, A M, Maritati, A, Tramontano, G, Capozzi, P, Goossens, E, Cotrone, C, Costantini, A, Ciliberti, M, Femiano, M, D'Amore, A, Forlenza, M, Ruggiero, R, Bianchi, A, Landier, Jean Augustin, Marrazzo, V, Dello Ioio, T, Capaldo, S, Crudeli, A, De Cesare, G, Cuccaro, F, Bracale, G, Tramontano, D, Postiglione, A, Matera, C, Coscioni, E, and Bousquet, J

Subjects
Active ageing, health tourism, age-friendly environments, age-friendly environment, Articles, innovation, accessibility
Abstract

In February 2017, the “Programma Mattone Internazionale Salute” (ProMis), that is the Italian Program for Internationalization of Regional Health Systems of the Ministry of Health (MoH), presented the first version of its Position Paper on Health Tourism, which embeds a first shared approach to the recommendations expressed by the European Committee of Regions (CoR) on “Age-Friendly” tourism. The CoR stresses the importance of local and regional authorities in the coordination of multi-sectoral policies such as healthcare, social assistance, transport, urban planning and rural development in relation to the promotion of mobility, security, accessibility of services, including health care and social services. “Age-friendly” tourism is an example of an innovative tourist offer that strives to meet the health needs of the entire “traveling” population, with an integrated and cross-sector approach that involves various organizations operating in sectors such as healthcare, accessibility and transport. The aim of the workshop was to explore the interest of the stakeholders to participate in a systemic action in the field of “health” tourism, and to identify priority implementation areas that offer opportunities to take advantage of validated, innovative experiences that strengthen the accessibility to health and social services in regional, national and international contexts. This effort provides the opportunity to take advantage of aligning the European Structural and Investment Funds (ESIF) to the development of tourism, coherently with the needs and resources of local and regional health authorities.

Published
2019

26. Next-generation ARIA care pathways for rhinitis and asthma: a model for multimorbid chronic diseases

Author

Bousquet, J. Jean Schunemann, Holger J. Togias, Alkis and Erhola, Marina Hellings, Peter W. Zuberbier, Torsten Agache, Ioana Ansotegui, Ignacio J. Anto, Josep M. Bachert, Claus and Becker, Sven Bedolla-Barajas, Martin Bewick, Michael and Bosnic-Anticevich, Sinthia Bosse, Isabelle Boulet, Louis P. and Bourrez, Jean Marc Brusselle, Guy Chavannes, Niels Costa, Elisio Cruz, Alvaro A. Czarlewski, Wienczyslawa Fokkens, Wytske J. Fonseca, Joao A. Gaga, Mina Haahtela, Tari and Illario, Maddalena Klimek, Ludger Kuna, Piotr Kvedariene, Violeta Le, L. T. T. Larenas-Linnemann, Desiree Laune, Daniel Lourenco, Olga M. Menditto, Enrica Mullo, Joaquin and Okamoto, Yashitaka Papadopoulos, Nikos Nhan Pham-Thi Picard, Robert Pinnock, Hilary Roche, Nicolas Roller-Wirnsberger, Regina E. Rolland, Christine Samolinski, Boleslaw Sheikh, Aziz Toppila-Salmi, Sanna Tsiligianni, Ioanna Valiulis, Arunas Valovirta, Erkka Vasankari, Tuula Ventura, Maria-Teresa Walker, Samantha Williams, Sian Akdis, Cezmi A. and Annesi-Maesano, Isabella Arnavielhe, Sylvie Basagana, Xavier and Bateman, Eric Bedbrook, Anna Bennoor, K. S. Benveniste, Samuel Bergmann, Karl C. Bia, Slawomir Billo, Nils and Bindslev-Jensen, Carsten Bjermer, Leif Blain, Hubert Bonini, Mateo Bonniaud, Philippe Bouchard, Jacques Briedis, Vitalis and Brightling, Christofer E. Brozek, Jan Buhl, Roland and Buonaiuto, Roland Canonica, Giorgo W. Cardona, Victoria and Carriazo, Ana M. Carr, Warner Cartier, Christine Casale, Thomas Cecchi, Lorenzo Cepeda Sarabia, Alfonso M. and Chkhartishvili, Eka Chu, Derek K. Cingi, Cemal Colgan, Elaine de Sousa, Jaime Correia Courbis, Anne Lise Custovic, Adnan Cvetkosvki, Biljana D'Amato, Gennaro da Silva, Jane and Dantas, Carina Dokic, Dejand Dauvilliers, Yves Dedeu, Antoni De Feo, Giulia Devillier, Philippe Di Capua, Stefania and Dykewickz, Marc Dubakiene, Ruta Ebisawa, Motohiro and El-Gamal, Yaya Eller, Esben Emuzyte, Regina Farrell, John and Fink-Wagner, Antjie Fiocchi, Alessandro Fontaine, Jean F. and Gemicioglu, Bilun Schmid-Grendelmeir, Peter Gamkrelidze, Amiran Garcia-Aymerich, Judith Gomez, Maximiliano Gonzalez Diaz, Sandra Gotua, Maia Guldemond, Nick A. Guzman, Maria-Antonieta Hajjam, Jawad Hourihane, John O'B Humbert, Marc Iaccarino, Guido Ierodiakonou, Despo Ivancevich, Juan C. Joos, Guy Jung, Ki-Suck Jutel, Marek Kaidashev, Igor and Kalayci, Omer Kardas, Przemyslaw Keil, Thomas Khaitov, Mussa Khaltaev, Nikolai Kleine-Tebbe, Jorg Kowalski, Marek L. Kritikos, Vicky Kull, Inger Leonardini, Lisa and Lieberman, Philip Lipworth, Brian Carlsen, Karin C. Lodrup and Loureiro, Claudia C. Louis, Renaud Mair, Alpana Marien, Gert and Mahboub, Bassam Malva, Joao Manning, Patrick Keenoy, Esteban De Manuel Marshall, Gallen D. Masjedi, Mohamed R. and Maspero, Jorge F. Mathieu-Dupas, Eve Matricardi, Poalo M. and Melen, Eric Melo-Gomes, Elisabete Meltzer, Eli O. Mercier, Jacques Miculinic, Neven Mihaltan, Florin Milenkovic, Branislava Moda, Giuliana Mogica-Martinezl, Maria-Dolores and Mohammad, Yousser Montefort, Steve Monti, Ricardo and Morais-Almeida, Mario Moesges, Raft Munter, Lars Muraro, Antonella Murray, Ruth Naclerio, Robert Napoli, Luigi and Namazova-Baranova, Leila Neffen, Hugo Nekam, Kristoff Neou, Angelo Novellino, Enrico Nyembue, Dieudonne O'Hehir, Robin and Ohta, Ken Okubo, Kimi Onorato, Gabrielle Ouedraogo, Solange Pali-Schoell, Isabella Palkonen, Susanna Panzner, Peter Park, Hae-Sim Pepin, Jean-Louis Pereira, Ana-Maria and Pfaar, Oliver Paulino, Ema Phillips, Jim Plavec, Davor and Popov, Ted A. Portejoie, Fabienne Price, David Prokopakis, Emmanuel P. Pugin, Benoit Raciborski, Filip and Rajabian-Soderlund, Rojin Reitsma, Sietze Rodo, Xavier and Romano, Antonino Rosario, Nelson Rottem, Menahenm Ryan, Dermot Salimaki, Johanna Sanchez-Borges, Mario M. Sisul, Juan-Carlos Sole, Dirceu Somekh, David Sooronbaev, Talant and Sova, Milan Spranger, Otto Stellato, Cristina Stelmach, Rafael Ulrik, Charlotte Suppli Thibaudon, Michel To, Teresa and Todo-Bom, Ana Tomazic, V, Peter Valero, Antonio A. and Valenta, Rudolph Valentin-Rostan, Marylin van der Kleij, Rianne and Vandenplas, Olivier Vezzani, Giorgio Viart, Frederic and Vieg, Giovanni Wallace, Dana Wagenmann, Martin Wang, De Y. and Waserman, Susan Wickman, Magnus Williams, Dennis M. and Wong, Gary Wroczynski, Piotr Yiallouros, Panayiotis K. and Yorgancioglu, Arzu Yusuf, Osman M. Zar, Heahter J. Zeng, Stephane Zernotti, Mario Zhang, Luo Zhong, Nan S. and Zidarn, Mihaela ARIA Study Grp MASK Study Grp

Abstract

Background In all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support the transformation of the health care system into integrated care with organizational health literacy. Main body As an example for chronic disease care, MASK (Mobile Airways Sentinel NetworK), a new project of the ARIA (Allergic Rhinitis and its Impact on Asthma) initiative, and POLLAR (Impact of Air POLLution on Asthma and Rhinitis, EIT Health), in collaboration with professional and patient organizations in the field of allergy and airway diseases, are proposing real-life ICPs centred around the patient with rhinitis, and using mHealth to monitor environmental exposure. Three aspects of care pathways are being developed: (i) Patient participation, health literacy and self-care through technology-assisted “patient activation”, (ii) Implementation of care pathways by pharmacists and (iii) Next-generation guidelines assessing the recommendations of GRADE guidelines in rhinitis and asthma using real-world evidence (RWE) obtained through mobile technology. The EU and global political agendas are of great importance in supporting the digital transformation of health and care, and MASK has been recognized by DG Sante as a Good Practice in the field of digitally-enabled, integrated, person-centred care. Conclusion In 20 years, ARIA has considerably evolved from the first multimorbidity guideline in respiratory diseases to the digital transformation of health and care with a strong political involvement.

Published
2019

27. ICT-Supported Interventions Targeting Pre-frailty: Healthcare Recommendations from the Personalised ICT Supported Service for Independent Living and Active Ageing (PERSSILAA) Study

Author

O’Caoimh, Rónán, Molloy, D. William, Fitzgerald, Carol, van Velsen, Lex, Cabrita, Miriam, Nassabi, Mohammad Hossein, de Vette, Frederiek, van Weering, Marit Dekker, Jansen-Kosterink, Stephanie, Kenter, Wander, Frazer, Sanne, Rauter, Amélia P., Turkman, Antónia, Antunes, Marília, Turkman, Feridun, Silva, Marta S., Martins, Alice, Costa, Helena S., Albuquerque, Tânia Gonçalves, Ferreira, António, Scherillo, Mario, De Luca, Vincenzo, Abete, Pasquale, Colao, Annamaria, García-Rudolph, Alejandro, Sanchez-Carrion, Rocío, Sánchez, Javier Solana, Gomez Aguilera, Enrique J., Illario, Maddalena, Hermens, Hermie, Vollenbroek-Hutten, Miriam, Maciaszek, Leszek, O Donoghue, John, Molloy, William, Rocker, Carsten, Ziefle, Martina, O'Caoimh, R., Molloy, D. W., Fitzgerald, C., Van Velsen, L., Cabrita, M., Nassabi, M. H., de Vette, F., van Weering, M. D., Jansen-Kosterink, S., Kenter, W., Frazer, S., Rauter, A. P., Turkman, A., Antunes, M., Turkman, F., Silva, M. S., Martins, A., Costa, H. S., Albuquerque, T. G., Ferreira, A., Scherillo, M., De Luca, V., Abete, P., Colao, A., Garcia-Rudolph, A., Sanchez-Carrion, R., Sanchez, J. S., Gomez Aguilera, E. J., Illario, M., Hermens, H., and Vollenbroek-Hutten, M.

Subjects
Gerontology, Institutionalisation, media_common.quotation_subject, Psychological intervention, Healthcare Recommendations, Pre-frailty, Guideline, Guidelines, 03 medical and health sciences, 0302 clinical medicine, Health care, media_common.cataloged_instance, 030212 general & internal medicine, European union, media_common, Information and Communication Technology, Nutrição Aplicada, Frailty, business.industry, Active ageing, Healthcare recommendation, Healthcare recommendations, Information and Communications Technology, Service (economics), Psychology, business, 030217 neurology & neurosurgery, Independent living, Information and communication technology, Estilos de Vida e Impacto na Saúde
Abstract

Part of the Communications in Computer and Information Science book series (CCIS, volume 869) As society ages, healthcare systems are preparing for an increasing prevalence of frail, co-morbid and older community-dwellers at risk of adverse outcomes including falls, malnutrition, hospitalisation, institutionalisation and death. Early intervention is desirable and pre-frailty, before onset of functional decline, may represent a suitable transition stage to target, albeit evidence for reversibility and appropriate interventions are limited. No consensus on the definition, diagnosis or management of pre-frailty exists. This work describes 25 healthcare related findings from the recently completed PERsonalised ICT Supported Service for Independent Living and Active Ageing (PERSSILAA) project, funded under the 2013–2016 European Union Framework Programme 7 (grant #610359). PERSSILAA developed a comprehensive Information and Communication Technologies (ICT)-supported platform to screen, assess, intervene and then monitor community-dwellers in two regions (Enschede in the Netherlands and Campania in Italy) in order to address pre-frailty and promote active and healthy ageing, targeting three important pre-frailty subdomains: nutrition, cognition and physical function. Proposed definitions of pre-frailty, ICT-based approaches to screen and monitor for the onset of frailty and targeted management strategies employing technology across these domains are described. The potential of these 25 healthcare recommendations in the development of future European guidelines on the screening and prevention of frailty is explored. PERSSILAA (PERsonalised ICT Supported Service for Independent Living and Active Ageing) from the European Community’s Seventh Framework Programme under grant agreement (FP7-ICT- 610359). Tânia Gonçalves Albuquerque acknowledges her PhD grant (SFRH/BD/99718/2014) funded by FCT, FSE and MEC info:eu-repo/semantics/publishedVersion

Published
2018

28. European Summit on the Prevention and Self-Management of Chronic Respiratory Diseases : report of the European Union Parliament Summit (29 March 2017)

Author

Hellings, Peter W., Borrelli, David, Pietikainen, Sirpa, Agache, Ioana, Akdis, Cezmi, Bachert, Claus, Bewick, Michael, Botjes, Erna, Constantinidis, Jannis, Fokkens, Wytske, Haahtela, Tari, Hopkins, Claire, Illario, Maddalena, Joos, Guy, Lund, Valerie, Muraro, Antonella, Pugin, Benoit, Seys, Sven, Somekh, David, Stjärne, Pär, Valiulis, Arunas, Valovirta, Erkka, Bousquet, Jean, Department of Dermatology, Allergology and Venereology, Clinicum, and HUS Inflammation Center

Subjects
Allergy, IMPACT, INNOVATION PARTNERSHIP, EUFOREA, RHINITIS, Mobile health technology, ALLERGY PROGRAM 2008-2018, CHRONIC RHINOSINUSITIS, Advocacy, eye diseases, Asthma, TIME, PRECISION MEDICINE, 3121 General medicine, internal medicine and other clinical medicine, GA(2)LEN, IMPLEMENTATION
Abstract

On March 29, 2017, a European Summit on the Prevention and Self-Management of Chronic Respiratory Diseases (CRD) was organized by the European Forum for Research and Education in Allergy and Airway Diseases. The event took place in the European Parliament of Brussels and was hosted by MEP David Borrelli and MEP Sirpa Pietikainen. The aim of the Summit was to correspond to the needs of the European Commission and of patients suffering from CRD to join forces in Europe for the prevention and self-management. Delegates of the European Rhinologic Society, European Respiratory Society, European Academy of Allergy and Clinical Immunology, European Academy of Paediatrics, and European Patients Organization EFA all lectured on their vision and action plan to join forces in achieving adequate prevention and self-management of CRD in the context of Precision Medicine. Recent data highlight the preventive capacity of education on optimal care pathways for CRD. Self-management and patient empowerment can be achieved by novel educational on-line materials and by novel mobile health tools enabling patients and doctors to monitor and optimally treat CRDs based on the level of control. This report summarizes the contributions of the representatives of different European academic stakeholders in the field of CRD.

Published
2017

29. Active and Healthy Ageing and Independent Living 2016

Author

Illario, Maddalena, Vollenbroek-Hutten, Miriam M. R., Molloy, D. William, Menditto, Enrica, Iaccarino, Guido, Eklund, Patrik, Illario, Maddalena, Vollenbroek-Hutten, Miriam M. R., William Molloy, D., Menditto, Enrica, Iaccarino, Guido, and Eklund, Patrik

Subjects
Quality of life, Population ageing, Social care systems, Article Subject, Geriatrik, IR-101822, lcsh:Geriatrics, lcsh:RC952-954.6, Editorial, METIS-318493, Geriatrics, indepent living, Geriatrics and Gerontology, EWI-27144, healthy ageing, Health care systems
Abstract

This article has no abstract

Published
2016

30. Is diet partly responsible for differences in COVID-19 death rates between and within countries?

Author

Bousquet, Jean, Anto, Josep M., Iaccarino, Guido, Czarlewski, Wienczyslawa, Haahtela, Tari, Anto, Aram, Akdis, Cezmi A., Blain, Hubert, Canonica, G. Walter, Cardona, Victoria, Cruz, Alvaro A., Illario, Maddalena, Ivancevich, Juan Carlos, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Laune, Daniel, Larenas-Linnemann, Désirée, Mullol, Joaquim, and Papadopoulos, Nikos G.

Subjects
COVID-19, ANGIOTENSIN converting enzyme, FOOD habits, ANIMAL nutrition, REGIONAL differences
Abstract

Reported COVID-19 deaths in Germany are relatively low as compared to many European countries. Among the several explanations proposed, an early and large testing of the population was put forward. Most current debates on COVID-19 focus on the differences among countries, but little attention has been given to regional differences and diet. The low-death rate European countries (e.g. Austria, Baltic States, Czech Republic, Finland, Norway, Poland, Slovakia) have used different quarantine and/or confinement times and methods and none have performed as many early tests as Germany. Among other factors that may be significant are the dietary habits. It seems that some foods largely used in these countries may reduce angiotensin-converting enzyme activity or are anti-oxidants. Among the many possible areas of research, it might be important to understand diet and angiotensin-converting enzyme-2 (ACE2) levels in populations with different COVID-19 death rates since dietary interventions may be of great benefit. [ABSTRACT FROM AUTHOR]

Published
2020
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31. Monitoring Biochemical and Structural Changes in Human Periodontal Ligaments during Orthodontic Treatment by Means of Micro-Raman Spectroscopy.

Author

Perillo, Letizia, d’Apuzzo, Fabrizia, Illario, Maddalena, Laino, Luigi, Di Spigna, Gaetano, Lepore, Maria, and Camerlingo, Carlo

Subjects
PERIODONTAL ligament, STRUCTURAL health monitoring, CORRECTIVE orthodontics, RAMAN spectroscopy, SPECTROMETRY, LIGAMENTS
Abstract

The aim of the study was to examine the biochemical and structural changes occurring in the periodontal ligament (PDL) during orthodontic-force application using micro-Raman spectroscopy ( μ-RS). Adolescent and young patients who needed orthodontic treatment with first premolar extractions were recruited. Before extractions, orthodontic forces were applied using a closed-coil spring that was positioned between the molar and premolar. Patients were randomly divided into three groups, whose extractions were performed after 2, 7, and 14 days of force application. From the extracted premolars, PDL samples were obtained, and a fixation procedure with paraformaldehyde was adopted. Raman spectra were acquired for each PDL sample in the range of 1000–3200 cm−1 and the more relevant vibrational modes of proteins (Amide I and Amide III bands) and CH2 and CH3 modes were shown. Analysis indicated that the protein structure in the PDL samples after different time points of orthodontic-force application was modified. In addition, changes were observed in the CH2 and CH3 high wavenumber region due to local hypoxia and mechanical force transduction. The reported results indicated that μ-RS provides a valuable tool for investigating molecular interchain interactions and conformational modifications in periodontal fibers after orthodontic tooth movement, providing quantitative insight of time occurring for PDL molecular readjustment. [ABSTRACT FROM AUTHOR]

Published
2020
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32. NutriLive: An Integrated Nutritional Approach as a Sustainable Tool to Prevent Malnutrition in Older People and Promote Active and Healthy Ageing—The EIP-AHA Nutrition Action Group

Author

Illario, Maddalena, Maione, Angela Serena, Rusciano, Maria Rosaria, Goossens, Edwig, Rauter, Amelia, Braz, Nidia, Jager-Wittenaar, Harriet, Di Somma, Carolina, Crola, Catherine, Soprano, Maria, Vuolo, Laura, Campiglia, Pietro, Iaccarino, Guido, Griffiths, Helen, Hartman, Tobias, Tramontano, Donatella, Colao, Annamaria, and Roller-Wirnsberger, Regina

Subjects
Article Subject
Abstract

The present document describes a nutritional approach that is nested in the European Innovation Partnership for Active and Healthy Aging (EIP-AHA) and aims to provide the first common European program translating an integrated approach to nutritional frailty in terms of a multidimensional and transnational methodology. The document has been developed by the A3 Nutrition Action Area of the EIP-AHA and aims at providing a stepwise approach to malnutrition in older citizens, identifying adequate interventions based on a unified assessment and ICT-supported solutions. “NutriLive” is an integrated nutritional approach, represented by a structured Screening-Assessment-Monitoring-Action-Pyramid-Model (SAM-AP). Its core concept is the stratification of the nutritional needs, considered by the working group as the key for targeted, effective, and sustainable interventions. “NutriLive” tries to close gaps in epidemiological data within an aging population, creating a unified language to deal with the topic of nutrition and malnutrition in Europe. By assembling all the validated screening, assessment, and monitoring tools on malnutrition in a first pyramid, which is interrelated to a second intervention pyramid, the A3 Nutrition WG identifies a common, integrated vision on the nutritional approach to frailty, which applies to the various health care settings.

Published
2016
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33. 269 Early Identification of Frailty: Developing an International Delphi Consensus for a Definition of Pre-frailty.

Author

Sezgin, Duygu, O'Donovan, Mark, Wong, Jean Woo, Bandeen-Roche, Karen, Liotta, Giuseppe, Fairhall, Nicola, Laso, Angel Rodríguez, Apóstolo, João, Clarnette, Roger, Holland, Carol, Roller-Wirnsberger, Regina, Illario, Maddalena, Mañas, Leocadio Rodríguez, Vollenbroek-Hutten, Miriam, Yavuz, Burcu Balam, Balci, Cafer, Pernas, Francisco Orfila, Paul, Costança, Ahern, Emer, and Romero-Ortuno, Roman

Subjects
CONFERENCES & conventions, CONSENSUS (Social sciences), FRAIL elderly
Abstract

Background Frailty is associated with a prodromal stage called pre-frailty, a potentially reversible and highly prevalent condition before frailty becomes established. Despite this, there is no widely accepted definition of pre-frailty to support its early identification and management. This study applied an international consensus approach to define and better understand pre-frailty. Methods A modified electronic two-round Delphi Consensus study was conducted. In all, 23 experts from 12 countries with different backgrounds participated. The questionnaire was developed following a systematic literature review. An online consensus meeting was conducted with eight Delphi participants and two external experts. Qualitative and quantitative methods were employed for data analysis. An agreement level of 70% was applied for accepting statements. Results A total of 71 statements were circulated in Round 1. Of these, 52.8% were accepted. Fifty-one statements were re-circulated in Round 2, of which 92.1% were accepted. The online consensus meeting produced a consensus statement describing the concept, multi-factorial nature, and mechanism of pre-frailty as well as assessment, prevention and management approaches. All experts agreed that physical and non-physical factors such as psychological and social capacity are involved in the development of pre-frailty, potentially adversely affecting health and health-related quality of life outcomes. Practitioners should regard pre-frailty as a multi-factorial, multi-dimensional, and non-linear process that does not inevitably lead to frailty. It might be reversed or attenuated by targeted interventions. Brief, feasible and validated tools are recommended for opportunistic screening or case-finding followed by confirmation with multi-dimensional assessment. Conclusion It is difficult to establish consensus on one compact definition of pre-frailty, which is a multi-dimensional concept not only associated with physical impairment, but also with cognitive, nutritional, socioeconomic and other aspects of frailty. However, it may be too early to agree on an operational definition of pre-frailty since none yet exists for frailty. [ABSTRACT FROM AUTHOR]

Published
2019
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34. GRKs and β-Arrestins: "Gatekeepers" of Mitochondrial Function in the Failing Heart.

Author

Sorriento, Daniela, Gambardella, Jessica, Fiordelisi, Antonella, Iaccarino, Guido, and Illario, Maddalena

Subjects
MITOCHONDRIAL physiology, ARRESTINS, HOMEOSTASIS, CELL death, HEART function tests, ORGANELLES
Abstract

Mitochondrial regulation of energy production, calcium homeostasis, and cell death are critical for cardiac function. Accordingly, the structural and functional abnormalities of these organelles (mitochondrial dysfunction) contribute to developing cardiovascular diseases and heart failure. Therefore the preservation of mitochondrial integrity is essential for cardiac cell survival. Mitochondrial function is regulated by several proteins, including GRK2 and β-arrestins which act in a GPCR independent manner to orchestrate intracellular signaling associated with key mitochondrial processes. It is now ascertained that GRK2 is able to recover mitochondrial function in response to insults. β-arrestins affect several intracellular signaling pathways within the cell which in turn are involved in the regulation of mitochondrial function, but a direct regulation of mitochondria needs further investigations. In this review, we discuss the recent acquisitions on the role of GRK2 and β-arrestins in the regulation of mitochondrial function. [ABSTRACT FROM AUTHOR]

Published
2019
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35. A case study of polypharmacy management in nine European countries: Implications for change management and implementation.

Author

McIntosh, Jennifer, Alonso, Albert, MacLure, Katie, Stewart, Derek, Kempen, Thomas, Mair, Alpana, Castel-Branco, Margarida, Codina, Carles, Fernandez-Llimos, Fernando, Fleming, Glenda, Gennimata, Dimitra, Gillespie, Ulrika, Harrison, Cathy, Illario, Maddalena, Junius-Walker, Ulrike, Kampolis, Christos F., Kardas, Przemyslaw, Lewek, Pawel, Malva, João, and Menditto, Enrica

Subjects
POLYPHARMACY, CHANGE management, DRUG marketing, TELECOMMUNICATION systems, HOSPITAL care
Abstract

Background: Multimorbidity and its associated polypharmacy contribute to an increase in adverse drug events, hospitalizations, and healthcare spending. This study aimed to address: what exists regarding polypharmacy management in the European Union (EU); why programs were, or were not, developed; and, how identified initiatives were developed, implemented, and sustained. Methods: Change management principles (Kotter) and normalization process theory (NPT) informed data collection and analysis. Nine case studies were conducted in eight EU countries: Germany (Lower Saxony), Greece, Italy (Campania), Poland, Portugal, Spain (Catalonia), Sweden (Uppsala), and the United Kingdom (Northern Ireland and Scotland). The workflow included a review of country/region specific polypharmacy policies, key informant interviews with stakeholders involved in policy development and implementation and, focus groups of clinicians and managers. Data were analyzed using thematic analysis of individual cases and framework analysis across cases. Results: Polypharmacy initiatives were identified in five regions (Catalonia, Lower Saxony, Northern Ireland, Scotland, and Uppsala) and included all care settings. There was agreement, even in cases without initiatives, that polypharmacy is a significant issue to address. Common themes regarding the development and implementation of polypharmacy management initiatives were: locally adapted solutions, organizational culture supporting innovation and teamwork, adequate workforce training, multidisciplinary teams, changes in workflow, redefinition of roles and responsibilities of professionals, policies and legislation supporting the initiative, and data management and information and communication systems to assist development and implementation. Depending on the setting, these were considered either facilitators or barriers to implementation. Conclusion: Within the studied EU countries, polypharmacy management was not widely addressed. These results highlight the importance of change management and theory-based implementation strategies, and provide examples of polypharmacy management initiatives that can assist managers and policymakers in developing new programs or scaling up existing ones, particularly in places currently lacking such initiatives. [ABSTRACT FROM AUTHOR]

Published
2018
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36. The Amino-Terminal Domain of GRK5 Inhibits Cardiac Hypertrophy through the Regulation of Calcium-Calmodulin Dependent Transcription Factors.

Author

Sorriento, Daniela, Santulli, Gaetano, Ciccarelli, Michele, Maione, Angela Serena, Illario, Maddalena, Trimarco, Bruno, and Iaccarino, Guido

Subjects
CARDIAC hypertrophy, TRANSCRIPTION factors, G protein-coupled receptor kinases, HEART cells, CALMODULIN
Abstract

We have recently demonstrated that the amino-terminal domain of G protein coupled receptor kinase (GRK) type 5, (GRK5-NT) inhibits NFκB activity in cardiac cells leading to a significant amelioration of LVH. Since GRK5-NT is known to bind calmodulin, this study aimed to evaluate the functional role of GRK5-NT in the regulation of calcium-calmodulin-dependent transcription factors. We found that the overexpression of GRK5-NT in cardiomyoblasts significantly reduced the activation and the nuclear translocation of NFAT and its cofactor GATA-4 in response to phenylephrine (PE). These results were confirmed in vivo in spontaneously hypertensive rats (SHR), in which intramyocardial adenovirus-mediated gene transfer of GRK5-NT reduced both wall thickness and ventricular mass by modulating NFAT and GATA-4 activity. To further verify in vitro the contribution of calmodulin in linking GRK5-NT to the NFAT/GATA-4 pathway, we examined the effects of a mutant of GRK5 (GRK5-NTPB), which is not able to bind calmodulin. When compared to GRK5-NT, GRK5-NTPB did not modify PE-induced NFAT and GATA-4 activation. In conclusion, this study identifies a double effect of GRK5-NT in the inhibition of LVH that is based on the regulation of multiple transcription factors through means of different mechanisms and proposes the amino-terminal sequence of GRK5 as a useful prototype for therapeutic purposes. [ABSTRACT FROM AUTHOR]

Published
2018
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37. Preventing and managing falls: an international online survey.

Author

Herzog, Carolin, Tramontano, Giovanni, Roller-Wirnsberger, Regina, Illario, Maddalena, Curran, Marie, and Hendry, Anne

Subjects
THERAPEUTICS, POSTURAL balance, COMMUNITY health services, CONFERENCES & conventions, HUMAN services programs, PRIMARY health care, ACCIDENTAL falls, ELDER care, OLD age
Abstract

Introduction: Rates of falls increase with ageing and age-related biological and functional changes. Most falls in later life occur as a result of a complex interaction between multiple intrinsic and environmental risk factors. Falls and falls-related injuries are major public health problems that often require healthcare intervention and rehabilitation (1) and recurrent falls are a frequent trigger for older people and their families seeking long term institutional care. Therefore, the prevention and management of falls has substantial relevance for integrated care systems. This study sought to obtain international insight into the implementation of pathways or programs addressing balance, mobility and/or falls prevention in primary care or community services. Methods: A survey template was created to include the key elements detected during a literature review conducted by MUG. The template included questions on screening, assessment, intervention components, target group, professionals involved and tools used for assessment and/or monitoring experience and outcomes. Members of IFIC's international Special Interest Groups(SIGs) on Ageing and Frailty, Intermediate Care were invited to complete an online EU Survey tool available from 01.06-01.08.2021. Responses were analysed by two researchers and results considered by the co-authors in an online focus group. Results: 16 people from 11 countries completed the online survey. 9/16 reported fully implemented falls programs or care pathways in their region or country: UK (3), Ireland (1), Spain (1), Indonesia (1), Peru (1), Australia (1) and Northwest USA (1). Seven examples are focused on older citizens but one is for older people with frailty & neurodegenerative diseases (New South Wales, Australia) and one is a pathway for patients in Indonesia, independent of disease and/or age limits. Professional disciplines involved differed across countries but allied health professionals and nurses were commonly involved. Family physicians were involved in only the examples from the USA and Indonesia. Specialist physicians in geriatric medicine were involved in five of the examples. Five programs involved pharmacists to advise on medication and two programs involved trained volunteers. Public/patient information and education was the most common intervention and was the sole intervention in the Spanish example reported. Three of the nine programs did not routinely evaluate patient experience or functional outcomes. Only three pathways enabled patient level data to flow through the electronic care record. Conclusion: The international survey offers initial insight into implemented pathways and programs for the prevention and management of falls in primary care and community settings in different countries. It paves the way for a more targeted survey and Delphi consensus process on the design and benchmarking of integrated services to address the challenge of falls in ageing societies. Implications: The evidence-based examples in the survey highlight processes and interventions that are readily transferable and where adoption will facilitate standardization and improved quality of care. The next phase aims to agree key components and performance indicators to allow future benchmarking and system-based evidence generation on prevention and management of falls in the community. [ABSTRACT FROM AUTHOR]

Published
2022
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38. THE "MPI PORTABLE" WEB-APP: A MULTI-LANGUAGE DIGITAL TOOL FOR THE CGA-BASED ASSESSMENT OF MULTIDIMENSIONAL FRAILTY IN OLDER PEOPLE IN DIFFERENT SETTINGS.

Author

Barbagelata, Marina, Volta, Erica, Cella, Alberto, Maresca, Federico, Ferri, Alberto, Lupo, Angelo, Bergotto, Carlo Berutti, De Benedetto, Marco, Iaccarino, Guido, Illario, Maddalena, Genazzani, Armando, Trompetto, Carlo, Mori, Laura, Arabia, Gennarina, Pignolo, Loris, Tonin, Paolo, Custodero, Carlo, and Pilotto, Alberto

Published
2022

40. Oxidative Stress Mediates the Antiproliferative Effects of Nelfinavir in Breast Cancer Cells.

Author

Soprano, Maria, Sorriento, Daniela, Rusciano, Maria Rosaria, Maione, Angela Serena, Limite, Gennaro, Forestieri, Pietro, D’Angelo, Dario, D’Alessio, Matteo, Campiglia, Pietro, Formisano, Pietro, Iaccarino, Guido, Bianco, Roberto, and Illario, Maddalena

Subjects
BREAST cancer diagnosis, CANCER cells, BREAST cancer patients, BREAST cancer treatment, OXIDATIVE stress
Abstract

The discovery of the anti-proliferative activity of nelfinavir in HIV-free models has encouraged its investigation as anticancer drug. Although the molecular mechanism by which nelfinavir exerts antitumor activity is still unknown, its effects have been related to Akt inhibition. Here we tested the effects of nelfinavir on cell proliferation, viability and death in two human breast cancer cell lines and in human normal primary breast cells. To identify the mechanism of action of nelfinavir in breast cancer, we evaluated the involvement of the Akt pathway as well as the effects of nelfinavir on reactive oxygen species (ROS) production and ROS-related enzymes activities. Nelfinavir reduced breast cancer cell viability by inducing apoptosis and necrosis, without affecting primary normal breast cells. The antitumor activity of nelfinavir was related to alterations of the cell redox state, coupled with an increase of intracellular ROS production limited to cancer cells. Nelfinavir treated tumor cells also displayed a downregulation of the Akt pathway due to disruption of the Akt-HSP90 complex, and subsequent degradation of Akt. These effects resulted to be ROS dependent, suggesting that ROS production is the primary step of nelfinavir anticancer activity. The analysis of ROS-producers and ROS-detoxifying enzymes revealed that nelfinavir-mediated ROS production was strictly linked to flavoenzymes activation. We demonstrated that ROS enhancement represents the main molecular mechanism required to induce cell death by nelfinavir in breast cancer cells, thus supporting the development of new and more potent oxidizing molecules for breast cancer therapy. [ABSTRACT FROM AUTHOR]

Published
2016
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41. A Community-Based, Technology-Supported Health Service for Detecting and Preventing Frailty among Older Adults: A Participatory Design Development Process.

Author

van Velsen, Lex, Illario, Maddalena, Jansen-Kosterink, Stephanie, Crola, Catherine, Di Somma, Carolina, Colao, Annamaria, and Vollenbroek-Hutten, Miriam

Subjects
*GERIATRIC nutrition, *FRAIL elderly, *INFORMATION technology, *MEDICAL care, *QUESTIONNAIRES, *SURVEYS, *THEMATIC analysis, *COMMUNITY services, *NUTRITIONAL status
Abstract

Frailty is a multifaceted condition that affects many older adults and marks decline on areas such as cognition, physical condition, and nutritional status. Frail individuals are at increased risk for the development of disability, dementia, and falls. There are hardly any health services that enable the identification of prefrail individuals and that focus on prevention of further functional decline. In this paper, we discuss the development of a community-based, technology-supported health service for detecting prefrailty and preventing frailty and further functional decline via participatory design with a wide range of stakeholders. The result is an innovative service model in which an online platform supports the integration of traditional services with novel, Information Communication Technology supported tools. This service is capable of supporting the different phases of screening and offers training services, by also integrating them with community-based services. The service model can be used as a basis for developing similar services within a wide range of healthcare systems. We present the service model, the general functioning of the technology platform, and the different ways in which screening for and prevention of frailty has been localized. Finally, we reflect on the added value of participatory design for creating such health services. [ABSTRACT FROM AUTHOR]

Published
2015
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42. Self-Assessment of Adherence to Medication: A Case Study in Campania Region Community-Dwelling Population.

Author

Menditto, Enrica, Guerriero, Francesca, Orlando, Valentina, Crola, Catherine, Di Somma, Carolina, Illario, Maddalena, Morisky, Donald E., and Colao, Annamaria

Subjects
CHI-squared test, CONFIDENCE intervals, STATISTICAL correlation, DRUGS, HEALTH, HEALTH education, HEALTH promotion, INTERVIEWING, CASE studies, MULTIVARIATE analysis, SCIENTIFIC observation, PATIENT compliance, SELF-evaluation, STATISTICS, SURVEYS, LOGISTIC regression analysis, PREDICTIVE validity, DESCRIPTIVE statistics, ODDS ratio
Abstract

Objectives. The aim of the study was to assess self-reported medication adherence measure in patients selected during a health education and health promotion focused event held in the Campania region. The study also assessed sociodemographic determinants of adherence. Methods. An interviewer assisted survey was conducted to assess adherence using the Italian version of the 8-item Morisky Medication Adherence Scale (MMAS-8). Participants older than 18 years were interviewed by pharmacists while waiting for free-medical checkup. Results. A total of 312 participants were interviewed during the Health Campus event. A total of 187 (59.9%) had low adherence to medications. Pearson’s bivariate correlation showed positive association between the MMAS-8 score and gender, educational level and smoking (P<0.05). A multivariable analysis showed that the level of education and smoking were independent predictors of adherence. Individuals with an average level of education (odds ratio (OR), 2.21, 95% confidence interval (CI), 1.08–4.52) and nonsmoker (odds ratio (OR) 1.87, 95% confidence interval (CI), 1.04–3.35) were found to be more adherent to medication than those with a lower level of education and smoking. Conclusion. The analysis showed very low prescription adherence levels in the interviewed population. The level of education was a relevant predictor associated with that result. [ABSTRACT FROM AUTHOR]

Published
2015
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43. Targeting the CaMKII/ERK Interaction in the Heart Prevents Cardiac Hypertrophy.

Author

Cipolletta, Ersilia, Rusciano, Maria Rosaria, Maione, Angela Serena, Santulli, Gaetano, Sorriento, Daniela, Del Giudice, Carmine, Ciccarelli, Michele, Franco, Antonietta, Crola, Catherine, Campiglia, Pietro, Sala, Marina, Gomez-Monterrey, Isabel, De Luca, Nicola, Trimarco, Bruno, Iaccarino, Guido, and Illario, Maddalena

Subjects
CARDIAC hypertrophy, GENE targeting, CALMODULIN, PROTEIN kinases, EXTRACELLULAR signal-regulated kinases, PHENYLEPHRINE, PREVENTION
Abstract

Aims: Activation of Ca2+/Calmodulin protein kinase II (CaMKII) is an important step in signaling of cardiac hypertrophy. The molecular mechanisms by which CaMKII integrates with other pathways in the heart are incompletely understood. We hypothesize that CaMKII association with extracellular regulated kinase (ERK), promotes cardiac hypertrophy through ERK nuclear localization. Methods and Results: In H9C2 cardiomyoblasts, the selective CaMKII peptide inhibitor AntCaNtide, its penetratin conjugated minimal inhibitory sequence analog tat-CN17β, and the MEK/ERK inhibitor UO126 all reduce phenylephrine (PE)-mediated ERK and CaMKII activation and their interaction. Moreover, AntCaNtide or tat-CN17β pretreatment prevented PE induced CaMKII and ERK nuclear accumulation in H9C2s and reduced the hypertrophy responses. To determine the role of CaMKII in cardiac hypertrophy in vivo, spontaneously hypertensive rats were subjected to intramyocardial injections of AntCaNtide or tat-CN17β. Left ventricular hypertrophy was evaluated weekly for 3 weeks by cardiac ultrasounds. We observed that the treatment with CaMKII inhibitors induced similar but significant reduction of cardiac size, left ventricular mass, and thickness of cardiac wall. The treatment with CaMKII inhibitors caused a significant reduction of CaMKII and ERK phosphorylation levels and their nuclear localization in the heart. Conclusion: These results indicate that CaMKII and ERK interact to promote activation in hypertrophy; the inhibition of CaMKII-ERK interaction offers a novel therapeutic approach to limit cardiac hypertrophy. [ABSTRACT FROM AUTHOR]

Published
2015
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49. Exploiting GRK2 Inhibition as a Therapeutic Option in Experimental Cancer Treatment: Role of p53-Induced Mitochondrial Apoptosis.

Author

Gambardella, Jessica, Fiordelisi, Antonella, Santulli, Gaetano, Ciccarelli, Michele, Cerasuolo, Federica Andrea, Sala, Marina, Sommella, Eduardo, Campiglia, Pietro, Illario, Maddalena, Iaccarino, Guido, and Sorriento, Daniela

Subjects
PROTEIN metabolism, ANIMAL experimentation, APOPTOSIS, CELL receptors, MICE, MITOCHONDRIA, PHOSPHORYLATION, PHOSPHOTRANSFERASES, THYROID gland tumors, TUMORS, IN vitro studies, IN vivo studies, CHEMICAL inhibitors
Abstract

Simple Summary: The involvement of GRK2 in cancer growth and an inverse correlation with p53 levels were suggested in breast cancer. Furthermore, increased GRK2 expression and activity were detected in thyroid cancer, but its effects and mechanisms of action were not investigated yet. This study aimed to explore the role of GRK2 in thyroid cancer both in vitro and in vivo and its crosstalk with p53. We demonstrated that thyroid cancer cells bearing a mutant form of p53 but not p53 null cells rely on GRK2 as a mechanism of proliferation by regulating p53 levels. Indeed, GRK2 indirectly induces p53 degradation through means of its catalytic activity. The pharmacological inhibition of the kinase effectively inhibits cancer growth by inducing p53-dependent mitochondrial pathways of apoptosis. Our results demonstrate a p53-dependent effect of GRK2 in cancer and suggest kinase inhibition as a potential therapeutic strategy for thyroid cancer. The involvement of GRK2 in cancer cell proliferation and its counter-regulation of p53 have been suggested in breast cancer even if the underlying mechanism has not yet been elucidated. Furthermore, the possibility to pharmacologically inhibit GRK2 to delay cancer cell proliferation has never been explored. We investigated this possibility by setting up a study that combined in vitro and in vivo models to underpin the crosstalk between GRK2 and p53. To reach this aim, we took advantage of the different expression of p53 in cell lines of thyroid cancer (BHT 101 expressing p53 and FRO cells, which are p53-null) in which we overexpressed or silenced GRK2. The pharmacological inhibition of GRK2 was achieved using the specific inhibitor KRX-C7. The in vivo study was performed in Balb/c nude mice, where we treated BHT-101 or FRO-derived tumors with KRX-C7. In our in vitro model, FRO cells were unaffected by GRK2 expression levels, whereas BHT-101 cells were sensitive, thus suggesting a role for p53. The regulation of p53 by GRK2 is due to phosphorylative events in Thr-55, which induce the degradation of p53. In BHT-101 cells, the pharmacologic inhibition of GRK2 by KRX-C7 increased p53 levels and activated apoptosis through the mitochondrial release of cytochrome c. These KRX-C7-mediated events were also confirmed in cancer allograft models in nude mice. In conclusion, our data showed that GRK2 counter-regulates p53 expression in cancer cells through a kinase-dependent activity. Our results further corroborate the anti-proliferative role of GRK2 inhibitors in p53-sensitive tumors and propose GRK2 as a therapeutic target in selected cancers. [ABSTRACT FROM AUTHOR]

Published
2020
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