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2024 MAR 9 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Current study results on Heart Disorders and Diseases - Heart Failure have [...]

A new paper published in Trends in Pharmacological Sciences by researchers at Insilico Medicine and ETH Zurich highlights the potential of TNIK as a therapeutic target for various aging-related diseases, including fibrosis, cancer, obesity, and Alzheimer's. The lead drug in Insilico's pipeline, INS018_055, is an AI-designed TNIK inhibitor currently in Phase II trials for idiopathic pulmonary fibrosis. TNIK has been found to play a significant role in cell migration, cytoskeletal organization, and cell proliferation in both healthy and malignant cells. The paper also explores TNIK's potential as a metabolic controller for combating obesity and Type 2 diabetes, as well as its emerging role in neurodegeneration. The researchers attribute TNIK's involvement in multiple diseases to its association with major hallmarks of aging. [Extracted from the article]

2020 JAN 9 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- New research on Women's Health - Obstetrics and Gynecology is the subject of a [...]

2019 APR 8 (NewsRx) -- By a News Reporter-Staff News Editor at Stem Cell Week -- Current study results on Cancer have been published. According to news reporting originating in [...]

The article discusses the position paper on hepatitis A vaccines issued by the World Health Organization (WHO) Strategic Advisory Group of Experts (SAGE) on Immunization at its meeting in April 2022 and replaces the 2012 WHO position paper. Topics include data in the updated 2022 systematic evidence review, such as data on efficacy, effectiveness and safety of multidose and single dose vaccines, and evidence generated from the 2012 systematic review considered in the updated paper.

A recent study conducted in Campinas, Brazil, provides recommendations for the diagnosis and treatment of post-extubation laryngitis (PEL) in children. The study utilized a modified Delphi method and involved specialists in pediatric otolaryngology and pediatric and neonatal intensive care. The study found that stridor was the most common symptom, and airway endoscopy was recommended for definitive diagnosis. Systemic corticosteroids, specifically dexamethasone, were recommended as part of the medical treatment. The study also highlighted the importance of a multidisciplinary approach in managing post-extubation laryngitis. [Extracted from the article]

A report from the State University of Campinas (UNICAMP) in Brazil provides recommendations for the diagnosis and treatment of post-extubation laryngitis (PEL) in children. The research involved a multidisciplinary expert-based opinion and used a modified Delphi method. The report highlights the importance of airway endoscopy in making treatment decisions, although there is no consensus on the dosage and length of treatment. The study also recommends the use of systemic corticosteroids, specifically dexamethasone, as part of the medical treatment for PEL. The management of post-extubation laryngitis is challenging and can benefit from a multidisciplinary approach. [Extracted from the article]

Now more than ever, health and safety are of the utmost importance. Even before the outbreak of COVID-19, consumers were taking a particular interest in their health and well-being. Currently, [...]

Researchers at the Ludeman Family Center for Women's Health Research at the University of Colorado Anschutz Medical Campus have published a paper in the Journal for Women's Health Research highlighting the need for improved diagnosis and treatment of coronary heart disease (CHD) in women. The paper emphasizes that CHD presents differently in women compared to men, leading to underdiagnosis and undertreatment in women and a higher mortality rate. The American Heart Association/American College of Cardiology has added a section to their Guideline for the Evaluation of Chest Pain focused on the unique symptoms experienced by women. The researchers hope that their paper will help healthcare providers better diagnose and treat CHD in women. [Extracted from the article]

The article discusses the April 2017 position paper on measles vaccination published by the World Health Organization (WHO). Topics explored include the declining incidence of measles during the 2000-2015 period which may be attributed to vaccination, infant mortality from measles in countries such as Nigeria, Pakistan and India, and details about the measles virus, diagnosis of this infection, and administration of measles vaccines.

The article discusses a position paper issued by the World Health Organization (WHO) on malaria vaccine and focuses on the evidence about the only candidate to have received a positive regulatory assessment. Topics cited include the main factors explaining why the burden of morbidity and mortality due to malaria is concentrated in sub-Saharan Africa such as poor housing conditions and the implementation of malaria control activities like the deployment of long-lasting insecticidal nets.

The article informs that Alnylam Pharmaceuticals Inc. has published a scientific paper on lipid nanoparticles for delivering ribonucleic acid interference (RNAi) therapeutics. It further informs that the research study was led by scientists from AlCana Technologies Inc. and the University of British Columbia. It mentions the RNAi therapeutics manufactured by the company which include ALN-TTR02 for treating transthyretin-mediated amyloidosis and ALN-PCS for treating hypercholesterolemia.

The article presents the position paper issued by the World Health Organization on human papillomavirus (HPV) vaccines. It offers information on HPV which is reportedly a common reproductive tract viral infection that can lead to various conditions including precancerous lesions. It explores the epidemiology of HPV-related diseases and discusses a multicentre clinical trial on the prevalence of HPV infection in heterosexual men.

The article discusses the position paper of the World Health Organization (WHO) on vaccination of Haemophilus influenzae type b (Hib). It mentions that the paper replaces the 2006 WHO position paper and summarizes developments in Hib vaccine. It presents the epidemiology of the Hib infection and disease, vaccines, and WHO position. It says the WHO recommends the inclusion of conjugate Hib vaccines in infant immunization programmes, given its shown safety and efficacy.

The article presents notes for a research paper on dysthymia published by Sara Biggs Chaney.

The article presents a position paper on hepatitis A vaccine which replaces the first WHO HAV position paper in 2000 and incorporates most recent developments. The paper mainly summarizes the background information on hepatitis A virus (HAV) such as its pathogenesis, clinical manifestations and etiological diagnosis. It includes the use of HAV vaccine in large-scale immunization programmes and the current WHO position on HAV vaccines worldwide.

The article reports on a series of updated position papers issued by the World Health Organization (WHO) regarding the vaccines and combinations of vaccines against diseases like pertusis that have an international public health impact. The position papers are concerned with the use of vaccines in immunization programmes. Moreover, the papers have been reviewed by many experts within and outside the organization.

A recent study conducted at Dartmouth College on fruit flies has provided evidence that oocytes, the cells that become eggs, regularly rejuvenate the protein linkages that bind chromosomes together. This finding could potentially help older women reduce their risk of pregnancy complications as they age. As women age, their oocytes also age, leading to a loss of cohesive linkages and an increased risk of miscarriages and chromosomal abnormalities in babies. The researchers discovered that in fruit fly oocytes, new cohesive linkages form on the chromosomes to replace the originals, suggesting that rejuvenation may be possible in human oocytes as well. Further research is needed to understand this process in humans and develop therapeutic strategies to enhance rejuvenation in older women. [Extracted from the article]

The article presents updated papers by the World Health Organization (WHO) on vaccines and combination of vaccines against diseases that have international public health impact. It states that influenza-associated diseases and deaths worldwide represent a public health problem with socioeconomic implications. WHO recommends seasonal influenza vaccination for pregnant women followed by children, the elderly, individuals with chronic conditions and health-care workers.

The article offers information on the World Health Organization (WHO) position paper on rubella vaccines, which aims to provide guidance on the use of vaccines in immunization. It says that rubella is a mild viral disease which commonly affects young adults and children worldwide. It mentions several licensed attenuated rubella vaccines such as TO-336, Matsuura, and Takahashi. Furthermore, the efficacy of rubella vaccine to prevent rubella and congenital rubella syndrome (CRS) is discussed.

The article presents a position paper on human rabies vaccines from the World Health Organization (WHO). It tackles the use of vaccines in large-scale immunization programmes, and explores combinations of vaccines that have an international public health impact. It incorporates developments in human rabies vaccine and provides grading tables that evaluate the quality of its scientific evidence.

This article discusses the integration of developmental and multi-level approaches in somatic process groups, with a focus on the importance of interpersonal relationships in therapeutic settings. The paper presents a somatico-developmental framework for trauma-healing methodologies, incorporating principles from somatic psychology, developmental sciences, and contemplative sciences. The authors introduce a case study of a 2-week residency program called "Relational Embodiment," which includes meditation, individual therapy, group sessions, and collective tasks. The article emphasizes the significance of interpersonal dynamics in somatic therapeutic contexts and suggests the use of participatory action research to enhance individual therapeutic processes. [Extracted from the article]

A research paper titled "Single-cell analysis of anti-BCMA CAR T cell therapy in patients with central nervous system autoimmunity" was published in the journal Science Immunology. The paper discusses the use of a fully human BCMA targeting autologous CAR-T cell injection called Equecabtagene Autoleucel in the treatment of patients with neuromyelitis optica spectrum disorder (NMOSD). The study analyzes the molecular characteristics of CAR-T cells in the central nervous system, reveals the mechanism of immune remodeling during CAR-T therapy, and compares the molecular differences of CAR-T cells between autoimmune diseases and cancers. The research provides insights into the potential of CAR-T cell therapy for autoimmune diseases. [Extracted from the article]

The article presents information on meningococcal vaccines. Meningitis is caused by meningococcus (Neisseria meningitidis). It gets transmitted through respiratory droplets and stays in human nasopharynx. Though it occurs in small outbreaks, it can appear as epidemics in some regions like the sub-Saharan Africa. Important risk factors include crowding, tobacco smoke, asplenia and human immunodefficiency virus (HIV) infection.

The article focuses on the aim of billionaire Li Ka-shing investment in Well Health Technologies Corp., a startup that's acquiring clinics and electronic medical records providers. Topics discussed include information on Canada's healthcare system that aim to providing free and tax-funded medical treatment; aim of Well Health Technologies Corp. to bringing software tools in clinics to make practices more efficient; and information of lack of adoption of medical technologies in Canada.

The author explores the effectiveness of creative writing as a tool for the reflective/reflexive practitioner. She states that writing freely in response to prompts from a tutor, or initiated by some impulse, opened up insights and intuitions that paralleled free association in the therapy room. She describes four exercises that she developed for exploring whether creative writing could develop reflexivity in a counsellor's exploration of her/his work with clients.

The article presents several studies on women's health in Great Britain. It includes a randomized, double-blind placebo-controlled trial to examine the effect of metformin on fat distribution and metabolic syndrome in women with polycystic ovarian syndrome, a randomized study of thromboprophylaxis in women with unexplained consecutive miscarriages, and the relation between hormone replacement therapy and coronary heart disease.

A recent study conducted by researchers at Graphic Era (Deemed to be University) in Uttarakhand, India, explores the pharmacological significance of Catharanthus roseus, also known as Vinca Rosea or Madagascar periwinkle, in cancer management. The study highlights the traditional uses and medicinal properties of alkaloids derived from C. roseus, including their efficacy in treating various cancers such as Hodgkin's lymphoma and leukemia. The research also discusses strategies for enhancing alkaloid production from C. roseus and provides insights into the signaling pathways and biological role of Vinca alkaloids in cancer. This study offers a comprehensive overview of the therapeutic potential of C. roseus in cancer treatment. [Extracted from the article]

A new study on head and neck cancer has been conducted by researchers at the First Hospital of Shanxi Medical University in China. The study aimed to understand the current research landscape of drug resistance in head and neck cancer. The researchers analyzed papers published between 2000 and 2023 and found that China and the United States were the major contributors in this field. The study identified key scholars and research hotspots, such as cisplatin resistance, metastasis, and ferroptosis. The findings provide valuable insights for researchers and highlight the current status and challenges in drug-resistant therapies for head and neck cancer. [Extracted from the article]

The article presents the views of general practitioners (GPs) on various health issues. Research conducted on topics including the use of corticosteroids over antibiotics in mildly infected eczema in children, impact of lifestyle changes on Haemoglobin (HbA1c) levels in type 2 diabetes patients, and omission of steroids for treating lower respiratory tract infection (LRTI) in non-asthmatic adults is discussed.

This article discusses the promise of stem cell therapies in the field of regenerative medicine and disease treatment. It explores the different types of stem cells, their unique properties, and their potential applications in treating various diseases. The paper also examines the current state of stem cell research, including successes and challenges, and addresses the ethical and regulatory considerations in this field. The aim of the article is to provide insights into the transformative potential of stem cell therapies, focusing on both current achievements and future prospects. Please note that this preprint has not yet undergone peer review. [Extracted from the article]

Suggests alternative uses of old copies of "The Saturday Evening Post." Shoe trees; Self-defense weapon; Therapeutics; Paper profit.

A recent scoping review conducted by researchers at the Keenan Research Centre for Biomedical Science in Toronto, Canada, explores the potential of microRNA (miRNA)-based therapies for sepsis. Sepsis is a life-threatening condition caused by a dysregulated response to infection, resulting in organ failure and high mortality rates. The review identified 51 articles that employed miRNA-based therapeutic interventions in animal models of sepsis, with 15 studies extending their inquiry to include or reference human clinical data. The findings suggest that miRNAs may hold promise as potential therapeutic candidates for sepsis-induced organ dysfunction. However, the review also highlights concerns regarding the quality and complexity of the biology and models used to assess therapeutic potential. [Extracted from the article]

A report from the University of Manchester discusses the use of Between-Session Homework (BSH) in psychotherapy. The research highlights the importance of BSH in driving change within various therapeutic approaches and emphasizes the need for therapists to have proficiency and competence in implementing BSH. The report provides an overview of the subject, empirical research supporting the efficacy of BSH, strategies for integrating and monitoring BSH in clinical practice, and ways to foster client engagement with BSH. The report also introduces six papers that further explore the topic. [Extracted from the article]

A recent study conducted by researchers at the University of Mumbai explores the potential of stem cell therapy in addressing neurological disorders such as Parkinson's Disease, Alzheimer's Disease, Multiple Sclerosis, Stroke, and Spinal cord injuries. The researchers highlight the increasing prevalence and complexity of these disorders and the need for effective medical interventions. The study examines the reparative and regenerative properties of stem cells and provides a comprehensive overview of their impact on expanding treatment options for neurological disorders. Real-life case studies are also evaluated to illustrate successful outcomes. [Extracted from the article]

A study conducted at Nanjing Xiaozhuang University explores the role of retinol in modern medicine, specifically its impact on obesity, type 2 diabetes, and cancer treatment. The research highlights the unique effects of retinol in preventing and treating metabolic diseases, as well as its potential applications in cancer therapy. The study analyzes the molecular mechanisms through which retinol influences disease states and discusses the challenges and prospects of its clinical application. The research concludes that retinol not only provides scientific evidence for further applications but also offers new therapeutic perspectives in clinical medicine. [Extracted from the article]

A study conducted at the Hebrew University of Jerusalem explores the role of artificial intelligence (AI) in mental health therapy, specifically focusing on the importance of empathy. The researchers propose a hybrid model where AI supports therapeutic processes without replacing the essential human elements of empathy and emotional engagement. The study emphasizes the nuanced role of empathy in therapy, highlighting that while AI can simulate empathic interactions, it lacks the ability to genuinely connect on an emotional level and care. The research suggests that AI can handle certain tasks in therapy, but human therapists should be involved in situations requiring deep empathy and compassion. [Extracted from the article]

A recent study conducted by researchers at Beijing Sport University explores the molecular mechanisms and therapeutic potential of lysophosphatidic acid (LPA) and its receptors in mood regulation. The study highlights the increasing prevalence of mood disorders, particularly among American adolescents and young adults, and the association between mood disorders and suicidal outcomes. The researchers conducted a comprehensive literature search and identified 21 scientific papers that suggest LPA/LPA receptor modulation could be beneficial in treating mood disorders. The study opens new avenues for future research into the influence of LPA and its receptors on emotional behavior in animals and humans. [Extracted from the article]

Epigenetics is the study of heritable changes in gene expression that do not involve alterations to the underlying DNA sequence. This paper explores the mechanisms of epigenetic regulation, their roles in various human diseases, and the current state of epigenetic therapeutics. Epigenetic modifications, such as DNA methylation and histone modification, can turn genes on or off without changing the DNA sequence, influencing cell differentiation, development, and responses to environmental factors. Abnormal epigenetic changes can lead to diseases such as cancer, neurological disorders, cardiovascular diseases, type 2 diabetes, and infections. Recent technological advancements have enhanced our ability to study and manipulate the epigenome, and epigenetic therapies, or "epidrugs," have shown promise in treating diseases with aberrant epigenetic modifications. However, challenges remain in achieving gene-specific targeting and minimizing toxicity and off-target effects. Future research should focus on improving the specificity and efficacy of epigenetic therapies and understanding the complex interactions between different epigenetic marks. [Extracted from the article]

A recent report from researchers at the Faculty of Pharmacy in Uttarakhand, India, highlights the increasing demand for herbal creams over synthetic creams due to their lower toxicity and fewer side effects. The report aims to provide clinical data-based evidence on the formulation and development of herbal creams, including their composition and manufacturing processes. The researchers reviewed 150 papers from 1995 to July 2023, focusing on various clinical and therapeutic applications of herbal creams, such as anti-inflammatory, dermatitis, anti-trauma, anti-aging, anti-acne, and vulvovaginal creams. However, the report concludes that more human clinical trials with larger sample sizes are needed to establish the safety and efficacy of herbal creams with higher accuracy. [Extracted from the article]

The article presents information on the health of women's bodies. There are numerous factors that cause women's breasts to change overtime like a change in exercise routine or use of birth control pills. Itching in the buttocks may be caused by an allergy to toilet paper and can be treated with hydrocortisone.

The article focuses on cytology procedures in veterinary dermatology, emphasizing its pivotal role in diagnosing various conditions such as infections and neoplasia. Topics covered include techniques for sample collection, staining methods like Diff-Quik, and microscopic examination, ensuring accurate identification and treatment guidance for dermatological issues in animals.