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Objective To study the m RNA expression of TNF-α and IL-6 in the peripheral blood from liver failure patients before and after MARS treatment in the improving and worsening groups. Methods Thirty-three patients with liver failure were treated with MARS treatment, and the expression of TNF-αmRNA and IL-6 mRNA in the peripheral blood of patients were detected using RT-PCR method. Results Strong positive expression could be observed in all liver failure patients before MARS treatment, while the strong positive expression rates of TNF-αmRNA and IL-6 mRNA of patients in improving group were lower than those in worsening group after MARS treatment. Conclusion TNF-αmRNA and IL-6 mRNA in the peripheral blood can be taken as an indicator for the prognosis of liver failure patients. [ABSTRACT FROM AUTHOR]

The pathological features of ankylosing spondylitis( AS) include inflammatory bone destruction and ectopic bone formation. Variety of cytokines and signaling pathways are involved in these two processes. At present,tumor necrosis factor-а and interleukins are most well-known inflammatory cytokines which lead to bone damage. Meanwhile, appearing of many newbiomarkers,such as Wnt / β-catenin signaling pathway and BMP / TGF-β signaling pathway,are attracting more and more attention.The study of the relationship between cytokines and signal pathways may reveal the mechanism of inflammation and pathological ossification in AS,which provides the evidence for the long-term use of anti-TNF drugs. [ABSTRACT FROM AUTHOR]

Objective　To compare the three low concentrationss of medical ozone for treating knee osteoarthritis （OA） through intra-articular injection using the established knee OA model in dogs．Methods　Forty healthy male dogs were randomly divided into Group A （the air group）， Group B （the １０ ug／ml medical ozone group）， Group C （the ２０ ug／ml medical ozone group）， and group D （the ３０ ug ／ml medical ozone group）， with １０ dogs in each group．The left knee joints were selected as Group N （the normal control group）．Hulth method was used to create OA model．The range of knee motion was measured before modeling， successful modeling， and before execution of the dogs．Nitrale reduetase （NR） method was used to detect the concentration of TNFa in the joints．Results　The range of knee motion in Group A decreased obviously after ８ weeks．The increased was more in Group B， C， and D after the therapy than that at the successful modeling．The range of knee motion in Group C increased more obviously than that in Group B and D （P ＜０．０５）．Articular cartilage pathological damage was found in the right knees of the dogs in ４ groups， and the most serious cartilage lesion was in Group A and the lest in group C．TNF－a concentration in Group C decrased more obviously than that in Group A， B， and D， which was of statistical difference （P ＜０．０５）．Conclusion　The ２０ ug／ml medical ozone can reduce inflammatory reaction， enhance the ability to eliminate free radicals of the body， and inhibit the expression of TNF-a. [ABSTRACT FROM AUTHOR]

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Objective: To study the Significance of interleukin-8 (IL-8), tumor necrosis factor-a (TNF-α) and insulin-like growth factor-I (IGF-I) expression changed in peripheral in chronic obstructive pulmonary disease(COPD)with acute exacerbation. Methods:100 cases acute exacerbation of COPD were selected from our hospital during the period from December 2013 to December 2014, as die observation group, and 100 cases healthy were also selected from the same period, as the control group, IL-8, TNF-α and IGF-I levels in peripheral of die study group before and after treatment stable and the control group were detected. Results: IL-S. TNF-α and IGF-I levels iii peripheral before treatment of the observation group were significantly higher than stable after treatment, the difference was statistically significant (P<0.05): IL-8. TNF-α and IGF-I levels in peripheral stable after treatment of the observation group were significantly higher than the control group, the difference was statistically significant (P<0.05). Conclusion: IL-S. TNF-α and IGF-I levels in peripheral in acute exacerbation of COPD were significantly increased, stable after treatment the levels can significantly reduced. IL-S. TNF-α and IGF-I levels has important implications for the diagnosis and treatment of COPD. [ABSTRACT FROM AUTHOR]