强直性脊柱炎炎性骨破坏和病理性骨化的信号转导机制.

The pathological features of ankylosing spondylitis( AS) include inflammatory bone destruction and ectopic bone formation. Variety of cytokines and signaling pathways are involved in these two processes. At present,tumor necrosis factor-а and interleukins are most well-known inflammatory cytokines which lead to bone damage. Meanwhile, appearing of many newbiomarkers,such as Wnt / β-catenin signaling pathway and BMP / TGF-β signaling pathway,are attracting more and more attention.The study of the relationship between cytokines and signal pathways may reveal the mechanism of inflammation and pathological ossification in AS,which provides the evidence for the long-term use of anti-TNF drugs. [ABSTRACT FROM AUTHOR]