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Objective To explore the predictive value of novel anthropometric indicators for the long-term prognosis in patients with acute myocardial infarction (AMI). Methods A total of 712 patients diagnosed with AMI in the People's Hospital of Xinjiang Uygur Autonomous Region from January 2018 to December 2019 were selected as research subjects, and divided into an event group and a non-event group according to whether major cardiovascular adverse events (MACEs) occurred during the period of follow-up. Gensini score was used to quantitatively assess the degree of coronary artery stenosis. Spearman correlation analysis was used to explore the correlation between the new anthropometric indicators and Gensini score. Receiver operating characteristic (ROC) curve was used to evaluate the ability of new anthropometric indicators to predict MACEs, and the patients were grouped according to the optimal cut-off value. Kaplan-Meier curve was used to analyze the survival difference between the groups. Multivariate Cox regression was used to analyze the independent risk factors of MACEs. Results During a median follow-up of 27 (20, 39 ) months, a total of 125 patients developed MACEs. As compared with those in the non-event group, the patients in the event group had a higher proportion of hypertension, diabetes and abdominal obesity, higher HbA1c and FBG levels, and longer body weight and waist circumference. The LAP index, CMI index, BRI index and Gensini score were significantly increased, and the differences were statistically significant (P < 0.05). Spearman correlation analysis showed that LAP index, CMI index and BRI index were positively correlated with Gensini score (r = 0.233, 0.126, 0.272, P < 0.001). ROC curve analysis showed that the AUC of LAP index, CMI index, VAI index, BRI index and ABSI index were 0.745, 0.640, 0.490, 0.874 and 0.506 respectively ; Kaplan-Meier curve analysis showed that the cumulative incidence of MACEs in LAP index, CMI index and BRI index was significantly increased in the high-value group (Log-rank test, P < 0.05). The results of multivariate Cox regression analysis after adjusting confounding showed that CMI index (HR = 1.430, 95%CI: 1.049 ~ 1.952, P = 0.024) and BRI index (HR = 1.332, 95%CI: 1.234 ~ 1.439, P < 0.001)were independent risk factors for MACEs. Conclusions CMI index and BRI index of new anthropometric indicators are independent risk factors for long-term prognosis in patients with AMI. [ABSTRACT FROM AUTHOR]

Background The occurrence and development of acute coronary syndrome (ACS) are closely associated with inflammatory responses, but the relationship between dietary inflammatory potential and severity of coronary artery disease of ACS patients is currently unknown. Objective To investigate the relationship between dietary inflammatory potential evaluated by dietary inflammation index (DII) and severity of coronary artery disease in ACS patients. Methods Convenient sampling method was used to select 309 patients diagnosed as ACS for the first time by coronary arteriography in the Department of Cardiology, the Second Affiliated Hospital of Harbin Medical University from April 2022 to March 2023, and they were divided into DII-1 group (from -8.35 to -4.56), DII-2 group (from -4.55 to -0.77), DII-3 group (from -0.76 to 3.02) and DII-4 group (from 3.03 to 6.81) according to the quartile of DII, into Q1 group (4-32 scores), Q2 group (34-52 scores), Q3 group (54-84 scores) and Q4 group (86-192 scores) according to the quartile of Gensini score. Demographic and clinical features, overall DII, and DII of nutrient were compared in ACS patients with different severity of coronary artery stenosis, multivariate Logistic regression analysis was used to analyze the relation of DII with the severity of coronary artery stenosis. Results There was significant difference in educational level, LDL-C, LP-a, overall DII, DII of total fat, saturated fatty acids, vitamin E, carotene in ACS patients with different severity of coronary artery stenosis, respectively (P≤0.05). After the correction of confounders of educational level, LDL-C and LP-a, the multivariate Logistic regression analysis showed that, DII-4 group was the influencing factor of Q2 group (OR=15.389, 95%CI=1.595-148.432), Q3 group (OR=15.102, 95%CI=1.620-140.788) and Q4 group (OR=17.319, 95%CI=1.901-157.807), respectively (P

Objective To investigate the relativity between levels of activated transcription factor 6 (ATF6) or calcium / calmodulin-dependent protein kinase Ⅱ (CaMKⅡ), and coronary heart disease (CHD) and the degree of coronary artery stenosis. To study their predictive value on CHD. Methods We selected 265 patients with CHD who had undergone coronary angiography, and collected their clinical data. According to the coronary angiographic results and the median of Gensini Score (38 points), these patients were divided into mild stenosis group (Gensini Score≤38 points, n = 105), moderate and severe stenosis group (Gensini Score>38 points, n = 100); those with normal coronary angiographic results were enrolled into control group (n = 60). The expression levels of ATF6 and CaMKⅡ were observed and statistically analyzed among the three groups. Results Compared with the control group, the levels of serum ATF6 and CaMKⅡ in the mild stenosis group, and moderate and severe stenosis group were both significantly higher; the levels increased with the increasing degree of coronary artery stenosis, with statistically significant differences (P<0. 05). According to Logistic regression analysis, ATF6 and CaMKⅡ may be independent risk factors for coronary heart disease. ROC curve analysis showed that the AUC value of the combination of serum ATF6 and CaMK Ⅱ in predicting CHD was 0. 749 ( 95% CI 0. 676 0. 822), with a sensitivity of 0. 663 and a specificity of 0. 717. Its diagnostic efficiency was higher than that of either of ATF6 or CaMKⅡ alone. Conclusion The levels of serum ATF6 and CaMKⅡ are positively correlated with the degree of coronary artery stenosis. The levels of ATF6 and CaMKⅡ have predictive value for CHD, which are expected to provide more references for diagnosing CHD and evaluating its severity [ABSTRACT FROM AUTHOR]

Objective To investigate the association between fibrinogen/albumin ratio （FAR） and the severity of coronary artery lesions in patients with premature coronary artery disease （PCAD）. Methods Clinical data of patients who initially underwent coronary angiography （CAG） due to chest pain， male patients aged < 55 years old and female aged < 65 years old， were collected. A total of 261 patients were recruited in this study. According to CAG results， all patients were divided into the non-coronary heart disease group and PCAD group. Relevant indexes and data of patients in two groups were collected and FAR was calculated. The degree of coronary artery lesions was evaluated according to the Gensini score （GS）. The differences of fibrinogen （Fib）， albumin （ALB） and FAR levels were compared between two groups， and the relationship between these three indexes and GS was discussed. Results Compared with the non-coronary heart disease group， the Fib and FAR levels were increased， whereas the ALB level was decreased in the PCAD group， and the differences were statistically significant （all P < 0.05）. Spearman correlation analysis showed that Fib and FAR levels were positively correlated with GS， while albumin level was negatively correlated with GS. Among three indexes， FAR had the highest correlation. Logistic regression analysis suggested that increased Fib and FAR levels were the risk factors for increased degree of stenosis of coronary lesions （OR>1）， whereas increased ALB level was a protective factor （OR

Background Coronary heart disease (CHD) is the leading cause of death world wide. Coronary angiography is often used as an effective approach for the diagnosis of CHD. However, coronary angiography accounts for relatively low percentagein examination approaches due to the limitation of various conditions in primary care, and more meaningful biomarkers need to be explored to provide a basis for primary care physicians to diagnose and treat CHD. In the previous study of our research group, it is found that early growth response 3 (Egr3) gene may be a susceptibility factor in the heterogeneity of CHD pathogenesis, and there are few reports on the correlation between CHD and Egr3 gene and inflammatory biomarkers. Objective To investigate the correlation between Egr3, interleukin-6 (IL-6) and CHD, as well as their expression levels and the severity of coronary stenosis, so as to provide a favorable laboratory basis for clinical diagnosis and treatment inprimary care. Methods A total of 110 patients who admitted to the Fifth Affiliated Hospital of Xinjiang Medical University for CHD symptoms and completed coronary artery angiography (CAG) during June to December 2021 were collected and divided into the mild stenosis group (group A≤52 points, n=50) , moderate-severe stenosis group (group B>52 points, n=30) and control group (group C, n=30) according to the CAG results and median Gensini score (52 points) . Serum Egr3 and IL-6 levels of the included patients were measured by enzyme-linked immunosorbent assay. Results The IL-6 level in group B was higher than that in group A and group C (P

Aim To investigate the correlation between triglyceride-glucose (TyG) index and the severity of coronary artery disease assessed in patients with acute myocardial infarction (AMI). Methods The study restrospectively selected 424 patients with AMI in the Fourth Affiliated Hospital of Xinjiang Medical University from January 2020 to March 2023. Clinical data and results of coronary angiography (CAG) were collected. Gensini score was used to quantitatively assess the degree of coronary artery stenosis. According to tertiles of the Gensini, the patients were classified into three groups: low Gensini score group (<45 points, n =140), medium Gensini score group (45 ~ 86 points, n =143), and high Gensini score group (≥87 points, n =141). The associations between TyG index and the occurrence of coronary artery disease with high Gensini score by Logistic regression analysis; Spearman correlation was used to analyze the correlation between TyG index and Gensini score in AMI patients; ROC curve was used to analyze the value of TyG index in predicting the severity of coronary artery lesions. Results TyG index of high Gensini score group was significantly higher than that of low and medium Gensini score group (P<0. 05). Logistic regression analysis showed that TyG index was an independent risk factor for severe coronary lesions in AMI patients (OR=13. 327, 95%CI: 2. 642 ~67. 235, P =0. 002). Spearman correlation analysis showed that TyG index was positively correlated with the severity of coronary artery disease (r =0. 331, P<0. 001). ROC curve analysis showed that the area under curve of TyG index was 0. 680 (95%CI: 0. 630 ~0. 731, P<0. 001). When the cut-off value of TyG index was 1. 555, the predicted efficacy of of severe coronary artery disease in patients with AMI was the highest, with a sensitivity of 79. 4% and a specificity of 50. 5%. Conclusion TyG, as a novel biomarker, was significantly and independently associated with the severity of the coronary arteries in patients with AMI. [ABSTRACT FROM AUTHOR]

Objective To investigate the association between fibrinogen/albumin ratio (FAR) and the severity of coronary artery lesions in patients with premature coronary artery disease (PCAD) . Methods Clinical data of patients who initially underwent coronary angiography （CAG) due to chest pain, male patients aged < 55 years old and female aged < 65 years old, were collected. A total of 261 patients were recruited in this study. According to CAG results, all patients were divided into the non-coronary heart disease group and PCAD group. Relevant indexes and data of patients in two groups were collected and FAR was calculated. The degree of coronary artery lesions was evaluated according to the Gensini score (GS) . The differences of fibrinogen (Fib), albumin (ALB) and FAR levels were compared between two groups, and the relationship between these three indexes and GS was discussed. Results Compared with the non-coronary heart disease group, the Fib and FAR levels were increased, whereas the ALB level was decreased in the PCAD group, and the differences were statistically significant (all P < 0.05) . Spearman correlation analysis showed that Fib and FAR levels were positively correlated with GS, while albumin level was negatively correlated with GS. Among three indexes, FAR had the highest correlation. Logistic regression analysis suggested that increased Fib and FAR levels were the risk factors for increased degree of stenosis of coronary lesions (OR>1), whereas increased ALB level was a protective factor (OR<1) .The receiver operating characteristic (ROC) curve showed that the area under the ROC curve (AUC) of Fib was 0.800, the sensitivity was 73.90% and the specificity was 83.20%. The AUC of ALB was 0.925, the sensitivity was 95.70% and the specificity was 85.30%. The AUC of FAR was 0.991, the sensitivity was 97.80% and the specificity was 93.70%. FAR was more valuable in predicting the degree of stenosis of coronary artery lesions than Fib and ALB. Conclusions FAR is positively correlated with GS, and closely correlated with the severity of coronary artery lesions in PCAD patients. FAR yields better value in predicting the severity of coronary artery lesions in PCAD patients than Fib and ALB. [ABSTRACT FROM AUTHOR]

Objective To investigate the correlation of monocytes and high-density lipoprotein cholesterol ratio(MHR) and albumin with the severity of coronary artery lesions in patients with unstable angina pectoris. Methods We enrolled 342 patients with unstable angina pectoris. According to the Gensini score of their coronary angiography results, they were divided into Gensini≤ 20 group, 2040 group. The differences in biochemical indicators between the groups were compared, and the correlation between the different indicators and the Gensini score was analyzed. According to the MHR quartile grouping, there were differences between the comparison groups. LDL-C was divided into subgroups and then subjected to multifactor Logistic regression analysis. Results MHR differed significantly among low, moderate and high grade lesions (P<0.05). Subgroup analysis showed that in low LDL-C group, Gensini score was positively correlated with MHR(P<0.05), while in high LDL-C group, Gensini score was negatively correlated with albumin(P<0.05). Multivariate Logistic regression analysis showed that the MHR level of patients with high Gensini score was 102.375 times higher than that of patients with low Gensini score(P<0.05). In the group with high LDL-C, the serum albumin level in the group with low Gensini score was 1.431 times that in the group with high Gensini score and 1.218 times that in the group with moderate Gensini score(all P<0.05). Conclusion In patients with unstable angina pectoris, especially when LDL-C levels are not high, both high MHR and low serum albumin are independent risk factors for the severity of coronary artery disease. [ABSTRACT FROM AUTHOR]

Objetive: To investigate the relationship between serum levels of alarin and chemerin and the presence and severity of coronary artery disease (CAD) in patients. The study population was constitutive of 112 CAD patients, who had performed the coronary angiography for suspecting CAD, and 86 healthy individuals as the control group. Angiographic CAD was defined as a narrowing of lumen diameter ≥ 50 % in at least one major epicardial coronary artery. The severity of CAD was identified by the Gensini score. Serum levels of alarin and chemerin were measured using enzyme linked immunosorbent assay (ELISA). Body mass index, systolic blood pressure, diastolic blood pressure, total cholesterol, triglycerides, and low density lipoprotein cholesterol and high density lipoprotein cholesterol levels were significantly higher in patients with CHD compared with healthy subjects in the control group (P<0.05); Serum alarin levels was notably higher in patients with CAD (n=112) than those in the control group (n=86) (0.62±0.18 vs. 0.41±0.19 μg/L, P<0.05). In addition, patients with CAD had higher alarin levels than healthy individuals (124.7±19.3 vs. 88.6±10.9 ng/mL, P<0.05). Serum alarin and chemerin levels had the significant positive correlation with the Gensini score, respectively (r=0.51， P<0.05; r=0.62, P<0.05). Multivariate logistic regression analysis indicated that serum alarin and chemerin levels were the independent predictors for identifying the existence of angiographic CAD (OR=0.91, 95%CI: 0.90-0.92; P<0.05 and OR=0.93，95%CI: 0.90-0.95; P<0.05, respectively). In this study, serum alarin and chemerin levels in patients with CAD were significantly higher than those in healthy subjects, and serum alarin and chemerin levels were significantly positively correlated with the severity of CAD. [ABSTRACT FROM AUTHOR]

To investigate the correlation between the levels of serum secreted curly protein 5 (SFRP5), fibroblasts growth factor 21 (FGF21) and insulin-like growth factor 1 (IGF-I) and blood lipids and the severity of coronary artery disease in patients with coronary atherosclerotic heart disease (CHD). A total of 109 patients with CHD (CHD group) who were admitted to our hospital from June 2018 to June 2021 were selected. According to the types of CHD, they were divided into stable angina group (SAP group, 32 cases), unstable angina group (UA group, 42 cases) and acute myocardial infarction group (AMI group, 35 cases). According to Gensini score, they were divided into mild lesion group (≤ 20 scores, 42 cases), moderate lesion group (21~40 scores, 44 cases) and severe lesion group (> 40 scores, 23 cases). 53 patients with normal results of coronary angiography in our hospital at the same time were selected as the control group. Serum SFRP5, FGF21, IGF-I and blood lipid levels were detected and compared in each group, and the correlation between serum SFRP5, FGF21, IGF-I and blood lipids and Gensini score were analyzed. The serum SFRP5, FGF21, IGF-I and HDL-C levels in patients with CHD with different types and degrees of coronary artery disease were lower than those in the control group, while the serum TC, TG and LDL-C levels were higher than those in the control group, the differences were statistically significant (P<0.05). The differences comparison of serum SFRP5, FGF21 and IGF-I levels showed that UA group was lower than SAP group, AMI group was lower than UA group, moderate lesion group was lower than mild lesion group, and severe lesion group was lower than moderate lesion group, the differences were statistically significant (P<0.05). The differences comparison of serum TC and LDL-C levels showed that UA group was higher than SAP group, AMI group was higher than UA group, moderate lesion group was higher than mild lesion group, and severe lesion group was higher than moderate lesion group, the differences were statistically significant (P<0.05). There were no significant differences in serum TG and HDL-C levels between SAP group, UA group and AMI group, as well as between mild lesions group, moderate lesions group and severe lesions group (P>0.05). Pearson correlation analysis showed that serum SFRP5, FGF21 and IGF-I levels were negatively correlated with TC, LDL-C and Gensini score (P<0.05). The serum SFRP5, FGF21 and IGF-I levels in patients with CHD are decreased, which are related to the increase of blood lipids level and the aggravation of CHD lesions. [ABSTRACT FROM AUTHOR]

Objective To evaluate the causes and influencing factors of re-hospitalization of patients with coronary heart disease by coronary angiography, so as to guide clinical diagnosis and treatment decisions and reduce re-hospitalization. Methods From January 2013 to December 2019, a total of 316 patients who were hospitalized twice with coronary angiography and/or percutaneous coronary intervention were analyzed retrospectively, including 235 males and 81 females, with a male to female ratio of 2.9∶1. According to the times of hospitalization, they were divided into the first hospitalization group and the second hospitalization group, with an average age of 59.45 ± 10.09 years and 60.47±10.16 years. The average time interval between the two hospitalizations was 14.30±11.67 months. Among them, 265 patients were diagnosed with coronary heart disease for the first time and percutaneous coronary intervention (PCI), accounting for 83%. Results After two hospitalizations, there were significant differences in LDL-C, TG, diabetes history smoking history, drinking history, first-time clinical diagnosis, severity of lesion (Gensini score) of each blood vessel (LAD, RCA, LCX), and stent placement of each blood vessel between the two groups (P < 0.05). The number of diabetic patients increased during the second hospitalization, with significant difference (P < 0.05) Multivariate Logistic regression analysis showed that LDL-C control was not up to standard, and the low rate of reaching the standard (13.3%, 31.0%) was an independent risk factor affecting the second hospitalization of patients with coronary heart disease (OR = 1.985, 95%CI 1.506 ～2.617). RCA, LAD and LCX were the protective factors for the second hospitalization of patients with coronary heart disease [(OR = 0.304, 95%CI 0.144～0.642), (OR = 0.184, 95%CI 0.099～0.343), (OR = 0.228, 95%CI 0.123 ～0.424)] Compared with those who were diagnosed as ST-segment elevation myocardial infarction (STEMI) for the first time, active revascularization treatment was a protective factor for re-hospitalization of patients who were diagnosed as stable angina pectoris (SAP), unstable angina pectoris (UAP) and non-ST-segment elevation myocardial infarction (NSTEMI) again [ (OR = 0.071, 95%CI 0.031～0.163), OR = 0.323, 95%CI 0.117～0.743, P < 0.05]. However, there was no significant difference in age, TC, HDL-C, Cre, BUN, UA, FPG, hypertension and vascular diseases of various coronary arteries (P > 0.05). Conclusion Strict control of LDL-C level in patients with coronary heart disease can effectively prevent and control the progress of diabetes, and actively carry out effective revascularization on seriously diseased coronary vessels during the first hospitalization can reduce the occurrence of second hospitalization. [ABSTRACT FROM AUTHOR]

Objective To analyze the relationship between methylenetetrahydrofolate reductase （MTHFR） gene polymorphism and severity of coronary heart disease. Methods A total of 400 patients who were to undergo coronary angiography and stent implantation when necessary were tested with folate metabolism 677 gene. And according to MTHFR C677T polymorphism，these patients were divided into three groups：C / C，C / T，T / T and Gensini score of coronary artery was used to evaluate the mace events （including cardiac death，myocardial infarction，heart failure，readmission for cardiac reasons and target vessel revascularization） within 180 days after PCI. Results （1） Patients with MTHFR C677T T/T genotype had significantly higher Gensini scores than those with C/T and C/C genotypes （P < 0.05）. （2） Patients with MTHFR C677T T/T genotype had significantly higher mace events than those with C/T and C/C genotypes after 180 days of PCI （P < 0.05）. Conclusion （1） There is a significant correlation between MTHFR gene polymorphism and severity of coronary heart disease；（2） There is a significant correlation between MTHFR gene polymorphism and the mace events after 180 days of PCI. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Modern Laboratory Medicine is the property of Journal of Modern Laboratory Medicine Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

To analyze the relationship between serum anti-apoptotic polypeptide (HN), C1q/TNF-related protein 3 (CTRP3) and blood lipid and severity of illness in patients with coronary heart disease. A total of 360 patients with CHD (CHD group) who were admitted to the Second Affiliated Hospital of Xi'an Medical University from January 2017 to December 2018 were selected, and 100 healthy subjects in the same period were selected as healthy control group (NC group), the serum HN, CTRP3, blood lipid and baseline data were compared between the two groups. CHD patients were divided into single-vessel lesion group (n=131), double-vessel lesion group (n=119) and multi-vessel lesion group (n=110) according to the number of lesion branches, .Gensini score was measured according to the results of coronary angiography, Pearson correlation analysis was used to analyze the correlation between HN and CTRP3 and blood lipid and Gensini scores. The proportion of smoking history, systolic blood pressure, fasting blood sugar, total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL-C) in CHD group were higher than those in NC group(P<0.05), while serum HN, CTRP3 and high density lipoprotein (HDL-C) were lower than those in NC group (P<0.05); The smoking history, fasting blood glucose, TC level and Gensini score in CHD double-vessel lesion group and multi-vessel lesion group were higher than those in single-vessel lesion group, and CTRP3 and HDL-C levels were lower than those in single-vessel lesion group. Systolic blood pressure in multi-vessel lesion group was higher than that in single-vessel lesion group, the smoking history, fasting blood sugar and Gensini score in multi-vessel lesion group were higher than those in double-vessel lesion group, and CTRP3 in multi-vessel lesion group was lower than that in double-vessel lesion group (all P<0.05). Pearson correlation analysis showed that serum HN level was positively correlated with HDL-C level in patients with CHD, and serum CTRP3 level was negatively correlated with Gensini scores in patients with CHD (P<0.05). The serum HN and CTRP3 levels are significantly decreased in patients with CHD. HN is positively correlated with HDL-C. The degree of CTRP3 reduction is related to the severity of illness in patients with CHD. It could be considered as an auxiliary serological index to evaluate the severity of illness in patients with CHD. [ABSTRACT FROM AUTHOR]

Objective To investigate the changes of serum IgG4 and high sensitivity Creactive protein(hs CRP) levels in patients with different subtypes coronary heart disease(CHD) before and after atorvastatin treatment and their correlation with the disease conditions of patients with CHD. Methods A total of 193 patients with CHD treated in the hospital from March 2017 to February 2018 were selected as research objects. All of the patients were divided into 3 subtypes group :unstable angina pectoris group(UAP group, n = 92) , stable angina pectoris (SAP group, n = 60) , acute myocardial infarction group (AMI, n = 41) . T he serum IgG4 and hs CRP levels were detected by double antibody sandwich enzyme linked immunosorbent assay in each subgroup. The correlation between IgG4, hs CRP levels and the coronary artery lesions count and Gensini score were analyzed. All of the patients were treated with atorvastatin (40 mg/d) for 1 month, the changes of IgG4 and hs CRP levels were observed before and after treatment. Results Before treatment, the IgG4, hs CRP levels and coronary artery lesions count, Gensini score: AMI group were higher or more than those of UAP group and SAP group, UAP group were higher or more than those of SAP group, the differences were statistically significant(P O. 05) ; IgG4 level of AMI group were higher than that of UAP group and SAP group, the differences were statistically significant (P 0. 05) . Compared with before treatment, the hs CRP levels of three groups were decreased after treatment, the differences were sta tistically significant (P< O. 05) , but there were no significant differences among each subgroup (P> O. 05) . Conclusions The serum IgG4 and hs CRP levels have significant differences in patients with different subtypes CHD, and positively correlated with the coronary artery lesions count and Gensini score. Atorvastatin can effectively reduce the levels of IgG4 and hs CRP. [ABSTRACT FROM AUTHOR]

Objective To investigate the relationship between the fragmented QRS (fQRS) and the degree of coronary artery lesion and left ventricular function in patients with non-ST elevation acute myocardial infarction (NSTEAMI). Methods Data of 183 patients with NSTEAMI who underwent coronary angiography in the department of cardiology of our hospital from January 2018 to October 2019 were retrospectively analyzed. According to the presence of fQRS (two or more adjacent leads) on the resting ECG, patients were divided into fQRS group (n=84) and nfQRS group (n=99). The clinical characteristics, coronary angiography data and echocardiography were analyzed between the two groups. Results The blood biochemical indexes such as cTnI, CK, CK-MB, LDH, TC, TG, LDL-C, Scr and hs-CRP were significantly increased in fQRS group compared to those of nfQRS group (P＜0.05). Gensini score and NT-proBNP value were significantly higher, LVEF was significantly lower, in fQRS group than those in nfQRS group (P＜0.01). Logistic regression analysis showed that the higher cTnI, CK-MB and Gensini score, and the lower LVEF were risk factors for fQRS in NSTEAMI patients. The fQRS group was then divided into two subgroups. The Gensini score of the lead number > 3 and the proportion of coronary artery lesion＞3 were significantly higher than those with the lead number≤3 group. Conclusion For NSTEAMI patients with fQRS on the ECG, especially those with more leads of fQRS, the coronary artery lesion is more serious, the left ventricular function is worse and myocardial ischemia is more severe. [ABSTRACT FROM AUTHOR]

Copyright of Imaging Science & Photochemistry is the property of Imaging Science & Photochemistry Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To observe the expression of serum microribonucleic acid-335 ( miR-335) and latent transforming growth factor binding protein 2 ( LTBP-2) in patients with coronary heart disease ( CHD)，and to explore its significance. Methods Totally 102 patients with CHD were divided into 36 cases of stable angina pectoris ( SAP) ( SAP group)， 32 cases of unstable angina pectoris ( UAP) ( UAP group)，and 34 cases of acute myocardial infarction (AMI) ( AMI group) according to the type of disease. According to Gensini score, 102 CHD patients were divided into the mild lesion group (37 cases)，moderate lesion group (40 cases)，and severe lesion group (25 cases). Another 40 patients with nonCHD diagnosed by coronary angiography were taken as the control group. The levels of fasting blood glucose, triglyceride (TG)，total cholesterol (TC)，low density lipoprotein cholesterol ( LDL-C )，and high density lipoprotein cholesterol (HDL-C) were measured by automatic biochemical analyzer. Real-time fluorescence quantitative polymerase chain reaction and enzyme-linked immunosorbent assay were used to detect the levels of serum miR-335 and LTBP-2，respectively. The relationships between severity of CHD and serum levels of miR-335 and LTBP-2 were analyzed by Preason correlation. Results There were no significant differences in systolic blood pressure，diastolic blood pressure，fasting blood glucose，TG， TC，LDL-C, or HDL-C between the control group, SAP group, UAP group, and AMI group ( all P > 0. 05 ) . The levels ofserum miR-335 in the control group, SAP group, UAP group, and AMI group decreased gradually, while the level of serum LTBP-2 increased gradually. The result of one-way anova showed that there was significant difference in serum level of miR335 and LTBP-2 between groups (all P < 0. 05). Pearson correlation analysis showed that the severity of CHD was negatively correlated with serum level of miR-335 (r = -0. 673, P < 0. 05 )，while was positively correlated with LTBP-2 ( r = 0. 705，P [ABSTRACT FROM AUTHOR]

Objective To investigate the correlation of Apo-A and Apo-B/Apo-A ratio with the degree of coronary artery stenosis (CHD) in patients with coronary heart disease. Methods Totally 234 patients with coronary heart disease examined with coronary angiography were collected. We collected blood lipid and calculated blood lipid ratio, such as non-HDL-C, TG/HDL-C, TC/HDL-C, LDL-C/HDL-C, and Apo-B/Apo-A. Gensini score was calculated according to the result of CAG. We analyzed the correlation between the blood lipid indicators and the Gensini score with the Spearman correlation analysis. Linear regression analysis was made of the correlation between those meaningful indicators and the Gensini score. Results There were no significant differences in age, hypertension, diabetes or smoking index between all Gensini score groups. The illness course in middle-score group was longer than that in low-score group and high-score group (P =0.023, P =0.002). There was a significant difference in Apo-A between the groups (P=0.009, P<0.001, P=0.013). The levels of TC, Apo-B and LPα in high-score group were lower than those in low-score group (P=0.008, P=0.001, P=0.002). The levels of HDL-C and Apo-B/Apo-A ratio in both middle-score and high-score group were lower than those in low-score group (P=0.008, P=0.001). The Spearman correlation analysis between various risk factors and Gensini score found that HDL-C and Apo-A had negative correlation with Gensini score (r=-0.166, r=-0.294), the ratios of LDL-C/ HDL-C and Apo-B/Apo-A were positively correlated with Gensini score (r=0.159, r=0.170). By multi-factor linear regression, Apo-A was negatively related with Gensini score (β= -62.249), and Apo-B/Apo-A ratio was positively associated with Gensini score (β =31.311). Conclusion Apo-A and Apo-B/Apo-A ratios are the independent risk factors for the stenosis degree of coronary artery in patients with CHD. They are reliable predictors for the risk of CHD. [ABSTRACT FROM AUTHOR]

Objective: To investigate the correlation of neutrophils/lymphocyte(NLR), mean platelet volume(MPV) with gensini score in Acute coronary syndrome(ACS). Methods: 156 cases of ACS patients were divided into three groups according to the results of coronary angiography: single lesion group, double branch lesions, tripathic group. The NLR, MPV, Gensini score and general clinical data were compared between different groups and the correlation of different index were analyzed. Results: Compared with the single vessel lesion group and double branch lesion group, the percentage of patients with smoking and diabetes, the serum LDL-C、HDL-C,UA, NLR, MPV and Gensini score were significantly increased in the three branches of lesion group(P<0.05); Compared with single vessel lesion group, the above index were significantly increased in he double branch lesion group(P<0.05). There was no significant difference in the age, gender, percentage of patients with hypertension, TC, TG and Cr between the three groups(P>0.05). The Pearson correlation analysis showed that NLR and MPV were positively correlated with Gensini score(r=0.482, 0.702, P<0.05). Conclusions: The MPV and NLR were significantly positive correlated with the degree of coronary artery disease in patients with ACS, and they can effectively assess the degree of coronary artery stenosis. [ABSTRACT FROM AUTHOR]

Objective: To investigate the correlation between serum lipoprotein related phospholipase A2 (Lp-PLA2), high sensitive C reactive protein (hs-CRP), interleukin-27 (IL-27) and matrix metalloproteinase-9 (MMP-9) levels and Gensini score in elderly patients with coronary heart disease. Methods: A total of 142 patient with coronary heart disease, who were treated in Second Affiliated Hospital of Army Medical University from October 2015 to February 2018 were chosen as research subjects and were divided into unstable angina pectoris (UAP) group (n=54), stable angina pectoris (SAP) group (n=40) and acute myocardial infarction (AMI) group (n=48) according to different types of coronary heart disease; meanwhile, the patients were further divided into mild (n=47), moderate (n=51) and severe (n=44) according to the Gensini score. The levels of Lp-PLA2, hs-CRP, IL-27, MMP-9 and Gensini score were compared among different coronary heart disease types and severity, and the correlation between the above indexes levels and Gensini score was analyzed. Results: The levels of Lp-PLA2, hs-CRP, IL-27 and MMP-9 and Gensini score in AMI group were higher than those in UAP group and SAP group, and the UAP group was higher than the SAP group (P<0.05). The levels of Lp-PLA2, hs-CRP, IL-27 and MMP-9 and Gensini score in severe patients were higher than those in moderate and mild patients,and moderate patients were higher than mild patients (P <0.05). The results of Spearman correlation analysis showed that Lp-PLA2, hs-CRP, IL-27 and MMP-9 levels were positively correlated with Gensini score in the patients with coronary heart disease (P <0.05). Conclusion: The levels of Lp-PLA2,hs-CRP, IL-27 and MMP-9 in the elderly patients with coronary heart disease are positively correlated with Gensini score of coronary artery disease, which is helpful to assess the severity of coronary heart disease in elderly patients according in the clinical application. [ABSTRACT FROM AUTHOR]

Objective: To investigate t he correlation between obstructive sleep apnea (OSA) and coronary vascular lesion se verity in the patients with acute coronary syndrome (ACS) . Methods: A total of 220 cases of ACS admitted and treated in the cardiology department of this hos pital from May to December 2019 were enrolled and completed the bedside sleep respiration monitaring by using Watch PAT 200™. According to the apnea hypopnea index (AHI), the cases were divided into the OSA group (AHI> 15, n = 139) and control group (AHI≤15, n = 81). The general clinical data and sleep monitoring data were collected for both groups. Then the correlation between OSA and coronary vascular injury severity in the OSA patients was analyzed. Results: The body mass index [(25.2± 3.3)kg/m²] and calcification semiquantitative score [ (2.7 ± 1.4) points] in the OSA patients of the OSA group were significantly higher than (24.2±3. 2) kg/ m² and (2.3±1.4) points in the control group, and the differences were statistically significant (P<0. 05) ; AHI had the positive correlation with coronary arterial calcification semiquantitative score (r = 0. 142, P = 0.035). Conclusion: The patients with ACS complicating OSA have a higher proportion, moreover their coronary arterial vascular calcification degree is higher. [ABSTRACT FROM AUTHOR]

Objective To investigate the correlation between heart rate variability { HRV ) indexes and coronary artery stenosis. Methods Ninety-six patients specifically diagnosed with coronary artery stenosis by coronary angiography were enrolled in this study. They had been admitted to our hospital from December 2015 to December 2017. According to the grading system of coronary artery stenosis) Gensini score) . they were divided into mild stenosis group(31 cases), moderate stenosis group (33 cases) and severe stenosis group(32 cases). All patients underwent 24-hour ambulatory electrocardiography examination. We [compared the HRV indexes among the 3 groups, including standard deviation of NN intervals! SDNN) . standard deviation of all 5-min averaged intervals( SDANN) . mot mean square of successive differences in RR interval( rMSSD) . percentage of RR intervals differing more than 50 ms from the preceding one( pNN50 ) . and the ratio of low frequency to high frequency ( LF/HF). Pearson linear correlation analysis was used to reveal the correlation between HRV and the severity of coronary artery stenosis ( Gensini score). Results SDNN. SDANN. rMSSD and pNN50 of mild stenosis group were higher than those of moderate and severe stenosis groups while these indexes of moderate stenosis group were higher than those of severe stenosis group, all with statistically significant differences( P <0.05 ). The LF/HF and Gensini scores of mild stenosis group were lower than those of moderate and severe stenosis groups while these indexes of moderate stenosis group were lower than those of severe stenosis group, all with statistically significant differences! P <0.05 ). Pearson linear correlation analysis revealed that SDNN. SDANN. rMSSD and pNN50 were negatively correlated with Gensini score( r = -0. 890, -0. 877. -0. 843 and -0. 802 ;P <0. 05 ). There was a positive correlation hetween LF/HF and Gensini score( r = 0. 872. P < 0. 05 ). Conclusion HRV indexes were different among the patients with varied severity of coronary artery stenosis. The more severe the coronary stenosis, the lower were SDNN. SDANN. rMSSD and pNN50. and the higher was LF/HF. and vice versa. HRV indexes were strongly correlated with the degree of coronary stenosis. [ABSTRACT FROM AUTHOR]

Objective To investigate the association of low level of free thyroxin (FT4) within normal range with the severity of coronary artery disease (CAD) and carotid atherosclerosis. Methods We enrolled 312 consecutive patients who underwent coronary angiography (CAG) and divided them into CAD group (196 cases) and non-CAD group (116 cases) according to CAG results. We calculated Gensini score and divided CAD group into≤10 Gensini score group (n=65), 10-30 Gensini score group (n=67) and >30 Gensini score group (n=64). Thyroid hormone level, carotid intima-media thickness (CIMT) and other clinical data were measured and compared between the groups, and the correlation analysis was used to find the relationship of FT4 level with Gensini score. By taking CIMT reference value of 0.9mm as the standard, we divided the patients into thickened IMT group (IMT≥0.9mm) and normal IMT group (IMT<0.9mm). Results The level of FT4 was significantly lower in CAD group and subgroups than in non-CAD group (P<0.05). The level of FT4 was negatively correlated with Gensini score (P<0.05). The levels of FT4 and TT4 were significantly lower in thickened CIMT group than in normal CIMT group (P<0.05). Conclusion Low level of FT4 within normal range is significantly related to the severity of CAD, and low level of FT4 can be used as an independent risk factor for the severity of CAD. Low levels of FT4 and TT4 are significantly related to carotid atherosclerosis. [ABSTRACT FROM AUTHOR]

Objective To investigate the risk factors for in-stent restenosis (ISR) after percutaneous coronary intervention (PCI). Methods We made a retrospective analysis of clinical and coronary angiographic data of 215 patients followed up with coronary angiography undergoing PCI in our hospital. The patients were divided into ISR group (n=102) and non-ISR group (n=113) according to the result of coronary angiography (CAG). The patients were also divided into two groups according to the serum level of high-sensitivity c-reactive protein (HsCRP). Univariate and multivariate regression analyses were performed to determine the relationship between the relevant factors and ISR. Results According to the univariate analysis, the morbidity rate of diabetes was higher in ISR group (43% vs. 30%, P<0.05). The patients in ISR group were significantly older [(68.31±8.24) vs. (65.27±9.69), P<0.05]. The HsCRP level of ISR group was higher than that of non-ISR group [(2.40±1.75)mg/L vs. (1.52±1.57)mg/L, P<0.001]. The serum total cholesterol level of ISR group was significantly higher than that of non-ISR group [(3.65±0.97)mmol/L vs. (3.35±0.88)mmol/L, P<0.05]. The serum low density lipoprotein cholesterol level was significantly higher than that of non-ISR group [(1.99±0.70)mmol/L vs. (1.74±0.74)mmol/L, P<0.05]. ISR group had higher Gensini score (P<0.001). However, Logistic multivariate regression analysis identified that only age, diabetes, HsCRP and Gensini score were independent predictors of ISR. Conclusion Age, diabetes, HsCRP and Gensini score are independent predictors of ISR. The serum total cholesterol and LDL-C levels are related to ISR, but they cannot be used independently as predictors of restenosis. [ABSTRACT FROM AUTHOR]

Objective： To explore the relationship between lgE levels in serum and coronary heart disease. Methods： All 135 en- rolled patients in our hospital were divided into the coronary heart disease （CHD） group and non-coronary heart disease （non-CHD） group according to the results of coronary angiography. The CHD group was subgrouped into stable angina pectoris （SAP） group, unsta- ble angina pectoris （UAP） group and acute myocardial infarction （AMI） group according to the clinical symptoms. The degree of arterial occlusion was quantified using the Gensini score. The total IgE level was measured by SIEMENS BNII automatic immuno scatter tur- bidimeter. The serum IgE levels between CHD and non-CHD group were compared, and a comparison of the IgE levels among SAP, UAP and AMI group was also carried out. Furthermore, the relationship of IgE ranges and Gensini score was analyzed. Results： The serum IgE level in non-CHD group （32.3 （13.5, 61） KU/L） was significantly lower than that of the CHD group （69 （26.4, 169） KU/L） （P=0.001）. And the serum IgE levels of UAP （78.6 （37.0, 191.0） KU/L） and AMI group （118.5 （75.3, 148.1） KU/L） were both significantly higher than that of the SAP group （36.7 （20.7, 96.7） KU/L） （P=0.034 and P=0.001）. Besides, we found that the serum IgE level of pa- tients with multi-vessel disease （67.2 （30.9, 249.0） KU/L） was significantly higher compared to that of patients with single-vessel disease （34.6 （18.1, 59.0） KU/L） （P=0.039）. Finally, Gensini score was increased with the increase of serum IgE level. Conclusions： Serum IgE level was increased in CHD patients compared with that in non-CHD ones. Moreover, serum IgE level was related to the state and severity of CHD, which may provide references for the diagnosis and monitoring of CHD. [ABSTRACT FROM AUTHOR]

Objective: To explore the role of platelet-to-lvmphocyte ratio(PLR) in evaluating the severity of coronary lesion in patients with acute coronary syndrome (ACS). Methods: A total of 168 patients with ACS who undergoing coronary angiography in department of cardiovascular medicine of Nanjing First Hospital were included in this study from March 2015 to March 2017. The severity of coronary artery was evaluated using Gensini score. A Spearman correlation analysis was used for the relationship between PLR and Gensini score. Results: There were significant differences irr the white blood cells, lymphocyte and low density lipoprotein between UA. NSTEMI and STEMI groups (P< 0.05). White blood cells and lymphocyte were higher irr STEMI group compared to that of UA and NSTEMI. and serum LDL level was significant lower than that of UA and NSTEMI groups. Further analysis showed that white blood cells and lymphocyte hi NSTEMI group were significantly higher than UA group, but LDL was lower than UA group. Moreover, the PLR and Gensini score in NSTEMI and STEMI groups were significantly higher than in UA group (P<0.05). There was a positive significant correlation between PLR and Gensini score (r=0.2205. P=0.0114). Multiple stepwise regression analysis showed that both PLR and white blood cells are influence factors for Gensini score. Conclusions: PLR is significantly related to the severity of coronary lesion. Higher level of PLR indicated more serious artery lesion in patients with ACS. [ABSTRACT FROM AUTHOR]

Objective: To investigate the correlation of thickness of epicardial adipose tissue (EAT) with the severity of coronary artery stenosis. Methods: 167 cases of patients were selected and allocated into 2 groups according to the coronary angiography(coronary arteriography, the CAG), normal coronary group（n=65cases）and coronary heart disease lesion group(1 coronary artery lesions in 50%or higher) or higher（n=102 cases）. Thoracic echocardiography was used to measure the EAT thickness and review the CAG image Gensini score. Results: The thickness of the EAT in the normal coronary group and coronary heart disease lesion group were 3.89± 0.2 mm, 6.19 ± 1.19 mm, which was significantly higher in the coronary heart disease group (P<0.001). The mean Gensini score of patients with thickness of EAT <5, 5-7 and >7 mm were 7.21± 7.73, 37.80 ± 29.55 and 29.55 ± 27.26; the Syntax score were 7.13 ± 7.70, 19.71± 7.27 and 7.27 ± 4.31. The EAT thickness and Gensini score (r = 0.621; P < 0.001), the Syntax score (r = 0.689, P < 0.001), and pathological changes of coronary heart disease were associated with the severity of coronary artery stenosis. Conclusions: EAT thickness and the complexity of the coronary artery stenosis and Gensini score, Syntax score. [ABSTRACT FROM AUTHOR]

Objective To investigate the relationship between the ratio of neutrophil to lymphocyte(NLR), hypersensitive Creactive protein(hs-CRP)and the severity of acute coronary syndromes(ACS). Methods From Jan.2017 to Feb.2018, 125 patients with ACS were enrolled as ACS group. 60 patients with suspicious angina pectoris symptoms such as chest pain and chest tightness but without obvious stenosis were enrolled as control gorup. The severity of coronary stenosis in ACS patients was evaluated according to Gensini score. According to GS score, ACS patients were divided into low level group, median level group and high level group. The levels of neutrophils, lymphocytes, NLR and hs-CRP were compared among the groups. Results The levels of neutrophils, NLR and hs-CRP in ACS group were significantly higher than control group(P<0.05). There were significantly differences in neutrophils and NLR values among the groups with different Gensini score(P<0.05). With the increasing of Gensini score, the levels of neutrophils and NLR increased gradually. There were no differences in lymphocyte and hs-CRP between any two groups(P>0.05). Conclusion NLR and hs-CRP could be independent risk factors of ACS. The level of NLR might be closely related to the degree of coronary stenosis, which could be used to predict the degree of ACS lesion. hs-CRP might not be correlated with the severity of ACS. [ABSTRACT FROM AUTHOR]

Objective: To investigate the correlation between the left ventricular mass index (LVMI) and the severity of coronary artery lesions of patients with coronary heart disease plus hypertension. Methods: 168 patients with coronary heart disease and high blood pressure were selected as the research objects. All patients after admission had heart ultrasound examination. According to the median level of LVMI, they were divided into groupA (LVMI≥ 115.71 g/m2, n = 82) and groupB (LVMI < 115.71 g/m2, n = 86). Record the general clinical data of patients and related laboratory examination indexes, coronary lesions and Gensini score, and compare the differences between the two groups. Multiple linear regression equation was applied to analyze the related factors influencing the Gensini score. Results: The systolic blood pressure (SBP), and levels of triglycerides (TG), b-type brain natriuretic peptide (BNP), serum creatinine (Scr) were higher in group A than in group B (P<0.05). Gensini score in group A was higher than in group B (P<0.05). And the proportion of triple vessel lesions was higher in group A than in group B (P<0.05). The LVMI was the highest in the group of high Gensini score (P<0.05), and lowest in the group of low Gensini score (P<0.05). Pearson correlation analysis showed that the Gensini score had positive correlation with LVMI (P<0.05). It was also positively correlated with SBP, TG, Scr, BNP (P<0.05). Multiple linear regression analysis showed that LVMI was an independent risk factor of the increased Gensini score (P<0.05). Conclusions: The increase of LVMI had positive correlation with the severity of coronary artery lesions of hypertension coronary heart disease patients combined with high blood pressure. LVMI could be the independent risk factor of the severity of coronary lesions. [ABSTRACT FROM AUTHOR]

Objective To investigate the relationship of high sensitivity C reactive protein (hs-CRP), interleukin-6 (IL-6) and soluble IL-6 receptor (sIL-6R) with the severity of clinical symptoms and coronary artery lesions in coronary heart disease (CHD) patients. Methods A total of 522 CHD patients were recruited and divided into three groups: stable angina pectoris (SAP), unstable angina pectoris (UAP) and acute myocardial infarction (AMI) groups. Another 102 healthy individuals served as normal controls (NCs). We calculated Gensini score according to the result of coronary angiography (CAG), collected clinical data and compared the groups. Multiple linear regression analysis was used to investigate the relationship of hs-CRP, IL-6 and sIL-6R with Gensini score. Results The plasma hs-CRP, IL-6 levels were significantly higher and sIL-6R level was signficantly lower in SAP, UAP and AMI groups than in NC group (P<0.05). There was a positive correlation between IL-6 level and Gensini score but a negative correlation between sIL-6R and Gensini score presented by multiple linear regression analysis (P<0.05). Conclusion In CHD patients, plasma hs-CRP, IL-6 and sIL-6R levels are significantly related to the severity of clinical manifestations and coronary artery stenosis. These indicators may help predict the severity of CHD. [ABSTRACT FROM AUTHOR]

Objective To investigate the correlation of endothelial inflammation in patients with acute myocardial infarction (AMI) with no-reflow and severity of coronary lesion. Methods A total of 120 patients with AMI were all treated with percutaneous coronary intervention (PCI). The patients who had intraoperative no-reflow were in case group (n=40). The patients who were also treated by PCI but did not have no-reflow in the same period in our hospital served as the control group (n=80). According to the results of coronary angiography, no-reflow group patients were divided into three subgroups: single lesion group (n=14), two-lesion group (n=10), and three-lesion group (n=16). We monitored these patients’ immediate postoperative endothelial microparticles (EMPs) and soluble intercellular adhesion molecule-1 (sICAM-1) levels in both groups with flow cytometry and ELISA methods. Results In the case group, immediate postoperative EMPs and sICAM-1 levels in the blood circulation were significantly higher than those in the control group. EMPs area and sICAM-1 area under the curve in the case group were 0.755 and 0.701, which showed that EMPs and sICAM-1 levels had a good correlation with the occurrence of non-reflow in AMI patients after PCI. Gensini score and EMPs level rose with the increase of the lesion counts, and the level of EMPs was positively correlated with Gensini score. Conclusion In patients with AMI, the EMPs and sICAM-1 levels can well predict the occurrence of no-reflow and are of some value in predicting the severity of coronary lesion. [ABSTRACT FROM AUTHOR]

Objective: To investigate the correlation between drinking, smoking and coronary lesion severity. Methods: 343 cases of male patients examined by coronary angiography were selected, those who had high blood pressure, diabetes, liver, renal dysfunction were excluded. The patients were divided into four groups, smoking and drinking group (86 cases), smoking + no drinking group (135 cases), no smoking+drinking group (16 cases), no smoking and no drinking group (106 cases). The situation of coronary artery was evaluated by Gensini coronary score, logistic regression analysis was performed to assess the risk factors of coronary artery lesion. Results: Gensini score is highest (33.89± 31.14) in smoking + no drinking group compared with that in other three groups (P＜0.05). Gensini score is 9.31± 10.88 in No smoking+drinking group, which was lower than other groups (P＜0.05). Univariate analysis showed that age, alcohol consumption, TG, HDL-C are risk factors for coronary heart disease, logistic regression analysis showed that alcohol consumption was protective factors of coronary heart disease, age and TG were risk factors of coronary heart disease. Conclusions: Smoking was a risk factor of coronary artery diseases, while drinking was a protective factor of coronary heart disease. [ABSTRACT FROM AUTHOR]

Objective: To analyze the correlation of lipoprotein(a) [Lp(a)] with the clinical stability and severity of coronary artery stenosis in patients with coronary artery disease (CAD)., Methods: A total of 531 patients undergoing coronary angiography in Nanfang Hospital between January, 2013 and December, 2016 were enrolled in this study. At the cutoff Lp(a) concentration of 300 mg/L, the patients were divided into high Lp(a) group ( n =191) and low Lp(a) group ( n =340). In each group, the patients with an established diagnosis of CAD based on coronary angiography findings were further divided into stable angina pectoris (SAP) group and acute coronary syndrome (ACS) group. The correlation between the severity of coronary artery stenosis and Lp(a) was evaluated., Results: The patients in high and low Lp(a) groups showed no significant differences in age, gender, body mass index, smoking status, hypertension, or diabetes ( P &gt;0.05). Multivariate logistic regression analysis revealed that age, gender, and serum levels of low-density lipoprotein cholesterol (LDL-C) and Lp(a) were independent risk factors for CAD in these patients. A high Lp(a) level was associated with an increased risk of CAD (OR=2.443, 95%CI: 1.205-4.951, P =0.013). The patients with a high Lp(a) level were at a significantly higher risk of CAD than those with a low Lp(a) level irrespective of a low or high level of LDL-C ( P =0.006 and 0.020). In the patients with CAD, the ACS group had a significantly higher Lp(a) level than the SAP group ( P &lt; 0.001); the proportion of the patients with high Gensini scores was significantly greater in high Lp(a) group than in low Lp(a) group (17.3% vs 5.6%, P =0.026), and a linear relationship was found between Lp(a) level and Gensini score (R=0.130, P =0.006)., Conclusions: Serum level of Lp(a) is an independent risk factor for CAD, and an increased Lp(a) is the residual risk for CAD. In patients with CAD, a high Lp(a) level is associated with the clinical instability and severity of coronary artery stenosis.

Objective: To investigate the correlation of the expression of platelet microRNA-223 (miR-223) with the degree of platelet activation and the severity of coronary lesions in patients with coronary artery disease (CAD). Methods: A total of 204 consecutive patients underwent coronary artery angiography (CAG) at Beijing Anzhen Hospital between April and December 2016 were enrolled. According to CAG results, all the patients were divided into two groups: 112 patients in CAD group and 92 patients in control group. Real-time fluorescent quantitative PCR was used to detect the expression level of platelet miR-223 and mRNA of its target gene P2Y12. Flow cytometry was performed to detect the expression of platelet associated complement-1 (PAC-1). Results: Compared with control group, the expression level of platelet miR-223 in CAD group was higher [(1.27 (1.17, 1.32) vs 0.73 (0.64, 0.79), P <0.001], while the expression level of P2Y12 mRNA was lower [0.75 (0.51, 0.96) vs 1.00 (0.80, 1.64), P <0.001]. The positive expression rate of PAC-1 of CAD group was higher than that of control group ( P <0.001). The expression level of platelet miR-223 was negatively correlated with the expression of P2Y12 ( r =-0.39, P =0.02), but positively correlated with the expression of PAC-1 ( r =0.50, P <0.001). The platelet miR-223 expression level had a positive correlation with the Gensini score in CAD group ( r =0.90, P <0.001), but had no significant correlation with platelet aggregation ( r =-0.06, P =0.36). Conclusion: The expression level of platelet miR-223 in patients with CAD may be an indicator for monitoring platelet activation and assessing the severity of CAD.