冠心病患者血清HN、CTRP3 与血脂及病情严重程度的关系研究*.

To analyze the relationship between serum anti-apoptotic polypeptide (HN), C1q/TNF-related protein 3 (CTRP3) and blood lipid and severity of illness in patients with coronary heart disease. A total of 360 patients with CHD (CHD group) who were admitted to the Second Affiliated Hospital of Xi'an Medical University from January 2017 to December 2018 were selected, and 100 healthy subjects in the same period were selected as healthy control group (NC group), the serum HN, CTRP3, blood lipid and baseline data were compared between the two groups. CHD patients were divided into single-vessel lesion group (n=131), double-vessel lesion group (n=119) and multi-vessel lesion group (n=110) according to the number of lesion branches, .Gensini score was measured according to the results of coronary angiography, Pearson correlation analysis was used to analyze the correlation between HN and CTRP3 and blood lipid and Gensini scores. The proportion of smoking history, systolic blood pressure, fasting blood sugar, total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL-C) in CHD group were higher than those in NC group(P<0.05), while serum HN, CTRP3 and high density lipoprotein (HDL-C) were lower than those in NC group (P<0.05); The smoking history, fasting blood glucose, TC level and Gensini score in CHD double-vessel lesion group and multi-vessel lesion group were higher than those in single-vessel lesion group, and CTRP3 and HDL-C levels were lower than those in single-vessel lesion group. Systolic blood pressure in multi-vessel lesion group was higher than that in single-vessel lesion group, the smoking history, fasting blood sugar and Gensini score in multi-vessel lesion group were higher than those in double-vessel lesion group, and CTRP3 in multi-vessel lesion group was lower than that in double-vessel lesion group (all P<0.05). Pearson correlation analysis showed that serum HN level was positively correlated with HDL-C level in patients with CHD, and serum CTRP3 level was negatively correlated with Gensini scores in patients with CHD (P<0.05). The serum HN and CTRP3 levels are significantly decreased in patients with CHD. HN is positively correlated with HDL-C. The degree of CTRP3 reduction is related to the severity of illness in patients with CHD. It could be considered as an auxiliary serological index to evaluate the severity of illness in patients with CHD. [ABSTRACT FROM AUTHOR]