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Objective：To investigate the effect of gonadotropin ⁃ releasing hormone agonist（GnRH ⁃ a）trigger on the laboratory technical indicators of embryos during natural cycle in vitro fertilization（IVF）in patients with diminished ovarian reserve（DOR). Methods：A retrospective study was conducted to analyze the data of patients with DOR who underwent natural IVF cycles in the Reproductive Medicine Center of the Affiliated Obstetrics and Gynaecology Hospital of Nanjing Medical University from January 1, 2018 to April 30, 2023. According to whether the GnRH⁃a trigger was used, the patients were divided into the trigger group and the non⁃trigger group, with 300 cycles in the trigger group and 47 cycles in the non⁃trigger group. A 1∶3 propensity score matching（PSM） was performed to compare the total number of oocytes retrieved, transferable embryos, high⁃quality embryos normal fertilization rate, oocyte utilization rate, high⁃quality embryos rate, and non⁃retrieved oocytes rate between the two groups. Results：A total of 165 cycles were included the（46 cycles in the non⁃trigger group and 119 cycles in the trigger group）after PSM, and the high⁃quality embryo rate in the trigger group was higher than that in the non⁃trigger group（61.1% vs. 35.0%, P=0.045). There were no significant differences in the total number of oocytes retrieved, the number of transferable embryos, the number of high⁃quality embryos, the normal fertilization rate, the oocyte utilization rate, and the non⁃retrieved oocyte rate between the two groups（all P > 0.05). Conclusion：The use of GnRH⁃a trigger during the natural cycle can improve the rate of high⁃quality embryos in patients with DOR. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effect of growth hormone (GH) supplementation on the clinical outcomes in non-diminished ovarian reserve(DOR) patients with previous in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) failure. Methods: It was a retrospective, self-controlled study. The clinical outcomes of the first and se cond IVF/ICSI cycle in 174 non-DOR patients undergoing the second IVF/ICSI cycle with GH supplement, from January 1st, 2018 to December 31st, 2021 in our center, were analyzed. Results: The gonadotropin(Gn) dosage per day, number of oocytes retrieved, 2PN cleavage rate, high-quality embryo rate, embryo implantation rate and clinical pregnancy rate were significantly increased, and Gn duration were significantly decreased in the GH group compared with control group(P＜0.05). The clinical pregnancy rate was not affected by the ovarian stimulation protocol, while the differences of Gn dosage, endometrial thickness, fertilization rate and abortion rate were not statistically significant (all P＞0.05). Subgroup analysis indicated that the antral follicle count (AFC), clinical pregnancy rate and live birth rate in the ＜35 years group were higher than those in the ≥35 years group (all P＜0.05)，while there were no significant differences in body mass index (BMI), anti-mullerian hormone (AMH), basic follicle stimulating hormone(FSH), Gn duration and dosage, endometrial thickness on the day of embryo transfer, number of oocytes retrieved, fertilization rate, 2PN cleavage rate, high -quality embryo rate, embryo implantation rate and abortion rate between the two groups(all P＞0.05). Conclusions: GH supplementation can improve the ovarian function and response, and clinical outcome for those non-DOR patients with previous IVF/ ICSI failure, especially for young patients. [ABSTRACT FROM AUTHOR]

Objective To explore the effectiveness of intraovarian injection of platelet-rich plasma(PRP) in the treatment of patients with diminished ovarian reserve(DOR), aiming to provide new diagnostic and therapeutic ideas for the treatment. Methods A total of 22 patients with DOR who underwent autologous PRP ovarian injection at the Reproductive Medical and Genetic Center of Qinzhou Maternal and Child Health Hospital from January 2021 to December 2023 were collected. Among them, 12 patients underwent assisted reproductive technology for pregnancy. The patient′s anti-Müllerian hormone (AMH), antral follicle count (AFC), basal follicle-stimulating hormone (FSH), basal luteinizing hormone (LH) and basal estradiol (E2) levels were observed. Results The levels of AMH, AFC, basal FSH, basal LH and basal E2 in 22 patients improved after treatment compared with those before treatment. Of the 12 patients who received assisted reproduction, 2 had IVF cycle canceled due to poor ovarian reaction. Ten patients obtained embryos, of which 5 obtained high-quality embryos. Conclusion Intraovarian injection of autologous PRP can effectively improve ovarian reserve function in patients with DOR.

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Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of International Reproductive Health/Family Planning is the property of Editorial Board of the Journal of International Reproductive Health/Family Planning and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Modern Laboratory Medicine is the property of Journal of Modern Laboratory Medicine Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的 比较高龄、低龄卵巢储备功能下降 (DOR) 患者联合应用重组人生长激素 (r-GH) 与脱氢表雄酮 (DHEA) 治疗前后血清卵巢功能相关指标。方法 54 例 DOR 患者按照年龄不同分为高龄组(≥35岁,29例)和低龄组(<35岁,25例),两组均于月经第3天开始每日皮下注射r-GH 2个单位,同时口服 DHEA 75 mg, 连续治疗3个月经周期。比较两组治疗前后血清卵泡刺激素 (FSH)、雌二醇(E_2)、抗苗勒氏管激素 (AMH)及窦卵泡数 (AFC)。结果 与同组治疗前比较,低龄组治疗后 AMH、AFC 升高,高龄组治疗后 FSH 水平降低 (P均<0. 05)。与高龄组比较,低龄组 AFC 治疗前后差值变化更为显著 (P <0. 05)。结论 r-GH 联合DHEA 治疗可改善女性卵巢功能,低龄女性改善更为明显,高龄女性无明显改善,仅表现为基础 FSH 水平下降。 [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To investigate the efficacy of combined laparoscopic-endoscopic lower esophageal sphincterotomy and modified Dor fundoplication for cardiochalasia patients., Methods: Clinical data of 11 cardiochalasia patients who underwent combined laparoscopic-endoscopic lower esophageal sphincterotomy and modified Dor fundoplication by the same medical team from January 2015 to December 2016 at The Second Hospital of Jilin University were retrospectively analyzed. The procedure was as follows: an incision was made in the anterior wall of esophagus and dissection of esophageal muscular layer was performed, then the bulged esophageal mucosa was covered by the fundus after 180 degrees fold to the right (fundoplication), finally the gastric fundus was joined to the right diaphragmatic foot by 3 to 5 knotted suture. The efficacy was judged by the Eckardt scoring standard: the postoperative Eckardt score ≤3 points indicated effectiveness, otherwise the treatment was invalid., Results: Combined laparoscopic-endoscopic lower esophageal sphincterotomy and modified Dor fundoplication was completed successfully in all the 11 patients without any subsequent laparotomy and death. The mean operative time was 85 (78 to 137) min, blood loss was 15 (5 to 35) ml, and no upper digestive tract perforation occurred. The mean postoperative hospital stay was 7.0(6 to 9) d. After the operation, the pressure of lower esophageal sphincter decreased significantly compared to that before operation [(5.31±6.23) mmHg vs. (35.72±17.13) mmHg, P<0.05], and the Eckardt score decreased significantly as well (0.53±0.56 vs. 6.17±1.17, P<0.05). During the follow-up of 2 to 23 months, there was no postoperative mortality. One case experienced mild gastroesophageal reflux 6 months after operation, and another patient had recurrent dysphagia 17 months after operation, who both were improved after receiving proton pump inhibitors or gastric dynamic drugs, and balloon dilation., Conclusion: Combined laparoscopic-endoscopic lower esophageal sphincterotomy and modified Dor fundoplication is an effective and safe surgical procedure for cardiochalasia with minimal invasion and fast recovery.

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Copyright of Journal of International Reproductive Health/Family Planning is the property of Editorial Board of the Journal of International Reproductive Health/Family Planning and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of International Reproductive Health/Family Planning is the property of Editorial Board of the Journal of International Reproductive Health/Family Planning and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To compare the efficacy and safety among laparoscopic Nissen, Toupet and Dor fundoplication in the treatment of hiatal hernia complicated with gastroesophageal reflux disease (GERD)., Methods: Clinical data of 276 patients of hiatal hernia complicated with GERD undergoing operation in our hospital from December 2012 to January 2015 were retrospectively analyzed, including 149 patients of laparoscopic Nissen fundoplication (Nissen group), 41 of laparoscopic Toupet fundoplication (Toupet group), and 86 patients of laparoscopic Dor fundoplication (Dor group). Esophageal reflux status, esophageal manometry, GERD Q rating scale, and postoperative recovery were compare among the three groups., Results: Reflux status was improved significantly in the three groups after operation(all P<0.05),except that the efficacy in reducing reflux episodes and reflux longest time was not obvious in Toupet group(P>0.05). There were no significant differences in postoperative reflux time, acid reflux time ratio, reflux longest time ratio, DeMeester score among the three groups (all P>0.05). Pairwise comparison showed that Dor group was significantly better than Toupet group in reducing the number of reflux episode(14.36±10.58 vs. 29.83±19.71) and long-reflux (0.64±0.21 vs. 6.20±3.48)(both P<0.05), but Nissen group was better than these two groups in reducing the number of long-reflux (0.38±0.16, P<0.05). As compared to pre-operation, the postoperative esophageal sphincter pressure and residual pressure increased significantly, and the relaxation rate reduced significantly (all P<0.05), while the episode of ineffective swallowing increased significantly in Toupet group (11.25±2.04 vs. 6.36±3.26, P<0.05). The contrast in esophageal manometry between Toupet and Dor group showed that Dor group was better than Toupet group in the recovery of lower esophageal sphincter pressure (mean resting breathing) [(20.69±13.95) mmHg vs.(12.91±6.89) mmHg] and the decrease of ineffective swallowing [9.15±6.44 vs. 11.25±2.04](both P<0.05), while such results of Dor group were similar to Nissen group[(19.87±10.40) mmHg, 6.15±2.95, all P>0.05]. The GERD Q scores were significantly decreased after operation in 3 groups(Nissen group:10.94±2.20 vs.7.41±1.43, t=11.667, P=0.001; Toupet group: 10.91±2.02 vs.7.18±1.33, t=5.109, P=0.005; Dor group: 10.69±1.69 vs. 7.10±1.30, t=7.610, P=0.002). There was no significant difference in GERD Q scores among three groups (F=1.465, P=0.207). The operative time, blood loss, hospital stay and complications were not significantly different among 3 groups (all P>0.05). Follow-up period was 12-51 months (median 19 months), and no significant difference in recurrence was found [Nissen group: 2 cases (1.3%), Toupet group: 1 case (2.4%), Dor group: 1 case (1.2%), χ 2 =0.363, P=0.834]., Conclusions: It is safe and feasible for these three laparoscopic fundoplications to the treatment of hiatal hernia complicated with GERD. But laparoscopic Nissen and Dor fundoplication are better than Toupet fundoplication in reducing the number of reflux episodes, suppressing long reflux, increasing lower esophageal sphincter pressure (mean resting respiration) and decreasing the incidence of postoperative dysphagia.

The geothermal resource has some advantages in energy-saving and emission-reduction. They include enormous reserves, high energy utilization efficiency, and low-cost operation and have played an important role in achieving the targets of carbon peak and carbon neutrality as the only renewable-clean energy on the planet that is not affected by weather and seasons. A systematical analysis of the developing courses and new progress of foreign countries’ middle-deep high-temperature geothermal resources was carried out to analyze the occurrence characteristics and development status of high-temperature geothermal resources. Furthermore, in comparison to the development of high-temperature geothermal resources in China, several suggestions which may provide a reference for the utilization of middle-deep geothermal resources in China are put forward for the actual demands. Conventional hydrothermal geothermal resources in China generally have mature power technology and significant potential. However, in comparison to the total resources, geothermal resources in China have a low development degree and significant development potential. Significantly, a variety of rare mineral resources are associated with geothermal fluids in China, but some issues exist in the development of the associated mineral resources in high-temperature geothermal fluids, such as unclear trace element distribution and development potential, resulting in a low level of resource development. Consequently, based on the potential evaluation of the associated mineral resources, comprehensive utilization of the associated mineral resources in deep geothermal fluids should be strengthened. High-temperature heat harm has become a significant problem as engineering construction in the high-temperature geothermal area has advanced, and the mining depth of mineral resources has gradually increased. The high-temperature heat harm not only has a serious impact on the health of workers but also impedes the construction process and raises costs. However, the resource attribute of high-temperature heat harm, on the other hand, has received little attention. Hence, there is relatively little research on the “resource utilization of heat energy” in deep mines and engineering construction, resulting in the waste of geothermal resources. Based on the potential evaluation of “heat harm resources,” more attention should be paid to the utilization of “heat harm resources” in engineering construction and “ore-thermal co-mining” in deep mines, as well as actively developing high-temperature heat harm resource utilization technology. In general, more attention should be paid to the development of China’s middle-depth geothermal resources. The development of an enhanced geothermal system based on conventional hydrothermal geothermal resources could be more effective. Furthermore, geothermal resource utilization should not be limited to geothermal fluid; associated mineral resources and high-temperature heat-harm resources have enormous resource potential as well.

Objective To evaluate the effectiveness of combining the GOAL questionnaire and Epworth sleepiness scale (ESS) for screening obstructive sleep apnea (OSA). Methods A total of 2,958 participants were recruited from the Sleep Medicine Center and underwent overnight polysomnography and screening questionnaires including GOAL, ESS, STOP - Bang questionnaire (SBQ), and NoSAS score. Sensitivity, specificity, positive predictive value, negative predic- tive value, diagnostic odds ratio (DOR), and area under the curve (AUC) were assessed for each tool. Results The GOAL questionnaire demonstrated higher sensitivity and DOR for OSA screening (sensitivity = 0.831; DOR 3.72) compared to the STOP - Bang questionnaire and NoSAS score. When the GOAL questionnaire was combined with the ESS, specificity and DOR significantly increased to 0. 894 and 4. 22, respectively. Participants with a GOAL score of 3 and ESS score 11 had a high likelihood (probability = 0.96) of OSA. Conclusion The combination of the GOAL questionnaire and ESS exhibits excellent diagnostic capabilities and effectively screens for OSA. Sequential screening with the GOAL questionnaire followed by ESS enhances predictive accuracy and facilitates early diagnosis in suspected OSA patients. [ABSTRACT FROM AUTHOR]

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Objective To systematically assess the available screening tools and to identify the most appropriate tool for screening sarcopenia in the community-dwelling elderly. Methods PubMed, Web of Science, CNKI, Wanfang Data, and VIP databases were searched to collect studies on the diagnostic accuracy of sarcopenia screening tools from database establishment to December 2022. Literature screening, data extraction, and risk bias evaluation were conducted by two researchers independently. Meta-analysis and network meta-analysis were performed using Stata 16.0 and R 4.4.2 software. Results A total of 22 studies comprising 10 969 participants were included. Eight screening tools were identified, including SARC-F (strength, assistance walking, rise from a chair, climb stairs and falls), CC (calf circumference), SARC-CALF (a combination of SARC-F with calf circumference), Mini Sarcopenia Risk Assessment questionnaire (MSRA-7, MSRA-5), SARC-F+EBM (SARC-F combined with age and BMI), Ishii test, and the finger ring test. The meta-analysis revealed that the area under the summary receiver operating characteristic curve (AUC) was 0.86 in SARC-CALF (95%CI: 0.82, 0.88), 0.85 in CC (95%CI: 0.81, 0.89), 0.80 in SARC-F (95%CI: 0.76, 0.83), 0.77 in MSRA-5 (95%CI: 0.73, 0.81), and 0.67 in MSRA-7 (95%CI: 0.63, 0.71), respectively. SARC-CALF, CC, and SARC-F showed relatively high accuracy, with SARC-CALF boasting the highest accuracy. The network meta-analysis revealed that SARC-CALF yielded higher diagnostic odds ratios (DOR) and superiority indices (SI) compared with SARC-F using the golden diagnostic criteria of AWGS 1, EWGSOP 1, EWGSOP 2, IWGS, and SCWD. Specifically, under the AWGS 1 criteria, both DOR and SI of SARC-CALF were found to surpass those of SARC-F and CC. Conclusion SARC-CALF should be advocated as the preferred screening tool for sarcopenia screening in the community-dwelling elderly. Further researches combined with risk prediction and interventions is needed to validate the comprehensive effectiveness of SARC-CALF. [ABSTRACT FROM AUTHOR]

Objective To explore the clinical effects of Tiaojing Zhuyun mixture combined with regulating menstration and promoting pregnancy by thirteen acupuncture in the treatment of Declining Ovarian Function (DOR) combined with follicular dysplasia infertility. Methods From January 1, 2022 to January 1, 2023, 60 cases of infertility patients with DOR follicular dysplasia were treated in our hospital, and the above cases were randomly divided into experimental group : Tiaojing Zhuyun mixture+ regulating menstration and promoting pregnancy by thirteen acupuncture + Clomiphene group ; Control group : Clomiphene group, 30 cases each. The improvement of FSH, maximum follicle size and ovulation, uterine artery blood flow index, endometrial thickness and pregnancy were observed after treatment. Results The improvement of follicle stimulating hormone, maximum follicle size, endometrial thickness and uterine artery blood flow indexes in Tiaojing Zhuyun mixture+ regulating menstration and promoting pregnancy by thirteen acupuncture + Clomiphene group were better than clomiphene group. The difference between groups was statistically significant (P < 0.05). The ovulation rate was 66.7% and the pregnancy rate was 40%. The ovulation rate was 40% higher than the control group, and the pregnancy rate was 20%. The difference between groups was statistically significant (P < 0.05). Conclusion In the patients with DOR follicular dysplasia infertility, Tiaojing Zhuyun mixture combined with regulating menstration and promoting pregnancy by thirteen acupuncture can improve the level of follicle stimulating hormone, promote follicular maturation and ovulation, reduce the resistance of uterine artery blood flow, increase the thickness of endometrial, promote pregnancy, and have fewer adverse reactions. [ABSTRACT FROM AUTHOR]

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Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To explore the protein differences between decreased ovarian reserve (DOR), premature ovarian failure (POF), and the normal control group using proteomic technology; and Additionally, to analyze the differential proteins to further elucidate the possible mechanisms of ovarian reserve decline and premature ovarian failure. Methods DOR model mice were prepared by a single intraperitoneal injection of 60 mg/kg cyclophosphamide combined with 6 mg/kg busulfan, while POF model mice were prepared by a single intraperitoneal injection of 120 mg/kg cyclophosphamide combined with 12 mg/kg busulfan. The mice′s estrous cycles were continuously observed after drug administration to determine the success of the modeling. After successful modeling, differential proteins were screened, and bioinformatics methods were used for functional annotation and enrichment analysis of the identified differential proteins to analyze their possible mechanisms. Results A total of 148 differential proteins with fold changes of more than 1.2 were screened in the DOR group, and 149 differential proteins were identified in the POF group. Enrichment analysis showed that the differentially expressed proteins in the DOR group were mainly involved in biological processes such as vitamin B6 metabolism, pyridoxal phosphate synthesis, and oxidative stress, and they were enriched in pathways such as vitamin B6 metabolism, α-linolenic acid metabolism, and PPAR signaling. On the other hand, the differentially expressed proteins in the POF group were mainly involved in biological processes such as lipid metabolism and inflammatory response, and they were enriched in pathways such as glycosphingolipid biosynthesis, arachidonic acid metabolism, and ribosome. Conclusion The pathogenesis of DOR and POF is complex, involving processes like oxidative stress and inflammatory response. The α-linolenic acid signaling pathway may be an important pathway involved in the occurrence of DOR, and HIST1 H1 C, CA3, and FABP4 may be important targets for its occurrence. The arachidonic acid metabolism signaling pathway may be an important pathway involved in the occurrence of POF, and HIST1 H1 C, D2 HGDH, and CYP4 F3 may be important targets for its occurrence. [ABSTRACT FROM AUTHOR]

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Objective To evaluate the efficacy of HE’ s Yangchao Granule(HSYC) combined with acupuncture for infertile patients with diminished ovarian reserve ( DOR) with kidney deficiency syndrome. MethodsThis was a randomized, double-blinded, controlled clinical trial. A total of 120 infertile patients with DOR with kidney deficiency syndrome were randomly assigned into the HSYC+sham-acupuncture group, placebo+acupuncture group, HSYC+acupuncture group, and placebo+shamacupuncture group at a 1 ∶1 ∶1 ∶1 ratio, with 30 patients each group. One menstrual cycle was one course of treatment, and all participants received three courses of treatment and were followed for an additional three months. Before and after each treatment course, anti-Müllerian hormone ( AMH), follicle stimulating hormone(FSH), and the value of FSH/luteinizing hormone(LH) were measured on the second or third day of menstruation through blood tests. Meanwhile, the antral follicle count(AFC) was examined by ultrasound. Before and after each treatment course, the traditional Chinese medicine(TCM) syndrome score and menstrual blood loss map score were calculated on the fifth day of menstruation. Besides, the pregnancy condition was followed three months after treatment. ResultsAfter three courses of treatment, compared with the placebo+sham-acupuncture group, AMH was increased (P<0. 05), AFC was increased (P <0. 05), FSH and FSH/ LH were decreased(P <0. 05) in the HSYC+acupuncture group. After three courses of treatment, compared with the placebo + sham-acupuncture group, the menstrual blood loss map score was increased (P<0. 05), and the TCM syndrome score was decreased (P<0. 05) in the HSYC+acupuncture, placebo+acupuncture, and HSYC+sham-acupuncture group. ConclusionThe combination of HSYC and acupuncture, or acupuncture, or HSYC has a certain effect on improving the TCM symptoms and menstrual blood volume of infertile patients with DOR with kidney deficiency syndrome. The combination of HSYC and acupuncture can significantly increase the level of AMH, reduce the level of FSH and the value of FSH/LH, and increase AFC of infertile patients with DOR with kidney deficiency syndrome, which is better than the effects of HSYC or acupuncture treatment alone. [ABSTRACT FROM AUTHOR]

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Copyright of Journal of Beijing University of Traditional Chinese Medicine is the property of Journal of Beijing University of Traditional Chinese Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Shanghai Jiaotong University (Medical Science) is the property of Journal of Shanghai Jiaotong University (Medical Science) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective　To observe the clinical efficacy of acupuncture and moxibustion combined with kidney-tonifying herbs in the treatment of diminished ovarian reserve ( DOR) with kidney-essence deficiency syndrome, and its effect on the oxidative stress of follicular fluid and the mitochondrial activity of ovarian granulosa cells in patients with DOR. Methods　Sixty DOR infertility patients with kidneyessence deficiency syndrome who were treated with assisted reproductive technology at Hebei Family Planning Science and Technology Research Institute and Hebei Reproductive and Gynecology Hospital from March 2018 to December 2019 were included as the observation objects. The patients were classified into the control group and observation group by random envelope, with 30 cases per group. The control group was treated with the conventional controlled ovarian hyperstimulation technique, while the observation group was treated with acupuncture and moxibustion combined with kidney-tonifying herbs on the basis of the control group. Acupuncture and moxibustion were performed once a week, with no acupuncture or moxibustion and no medication during menstruation. The patients were subjected to continuous treatment for three menstrual cycles, traditional Chinese medicine(TCM) syndrome scores, number of oocytes retrieved, fertilization rate, cleavage rate, excellent embryo rate, cancellation rate of transplantation, and clinical pregnancy rate were observed and compared between the two groups. On the day of serum human chorionic gonadotropin ( hCG) injection, the levels of serum estradiol and progesterone were detected. The levels of superoxide dismutase (SOD), glutathione peroxidase (GSHPx), catalase (CAT), and malondialdehyde (MDA) in the follicular fluid, as well as the mitochondrial activity in ovarian granulosa cells were detected in the laboratory. Results 　There was no significant change in TCM syndrome scores in the control group before and after treatment. Compared with the control group after treatment, the TCM syndrome scores in the observation group were lower than those in the control group, and the TCM syndrome scores in the observation group after treatment were lower than those before treatment (P<0. 05). In the observation group, the excellent embryo rate increased, and the cancellation rate of transplantation decreased compared with those in the control group (P<0. 05). There was no significant difference in the number of oocytes retrieved, fertilization rate, cleavage rate, and clinical pregnancy rate in the observation group compared with those in the control group. The levels of serum estradiol and progesterone in the observation group were higher than those in the control group on the day of hCG injection (P<0. 01). Compared with the control group, the content of GSH-Px in the follicular fluid in the observation group was increased(P<0. 05), the levels of SOD, CAT and MDA were not significantly different, and the mitochondrial activity of ovarian granulosa cells was enhanced (P < 0. 05). Conclusion　Acupuncture and moxibustion combined with kidney-tonifying herbs can improve the symptoms of kidney deficiency in DOR patients with kidney-essence deficiency syndrome, and can also effectively increase the levels of serum estradiol and progesterone on the day of hCG injection, increase the excellent embryo rate, and reduce the cancellation rate of transplantation. The mechanism may be related to the enhancement of follicular fluid GSH-Px activity and the enhancement of mitochondrial activity of ovarian granulosa cells. [ABSTRACT FROM AUTHOR]

Objective To compare clinical efficacy of three different ovulation induction protocols in the treatment of the patients with diminished ovarian reserve (DOR). Methods The clinical data of 207 fresh cycles and 139 frozen embryo transfer cycles of DOR patients who received in vitro fertilization or intracytoplasmic sperm injection in the Reproductive medicine center of Zhongda hospital affiliated to southeast university from August 2018 to October 2021 were retrospectively analyzed. According to different ovulation induction protocols, they were divided into GnRH-antagonist protocol group (32 cycles), Mini-stimulation protocol group (107 cycles) and Luteal-phase ovarian stimulation protocol group (68 cycles). The general situation, medicationin in treatment, laboratory indexes, effects and clinical outcomes were compared among groups. Results The total amount of gonadotropin (Gn), days of Gn, the number of eggs retrieved and the amount of Gn required for each mature (MIi) egg in the mini-stimulation protocol group were lower than those in the other two groups (P < 0. 05), the estradiol level on trigger day in the mini-stimulation protocol group was lower than that in the GnRH-antagonist protocol, and the level of luteinizing hormone on trigger day in the luteal-phase ovarian stimulation protocol group was lower than that in the other two groups ( P < 0. 05). The number of MIi eggs in the GnRH-antagonist protocol group was higher than in the ministimulation protocol groups (P < 0. 05), and the clinical pregnancy rate in the GnRH-antagonist protocol group was higher than those in the other two groups (P < 0. 05). The number of transplantable embryos in GnRH-antagonist protocol group was slightly higher than that in the other two groups (P = 0. 052). There were no significant differences in abortion rate and live birth rate among the three groups (P >0. 05). Conclutions GnRH-antagonist protocol can make DOR patients obtain more MIi eggs and transplantable embryos, and can improve the pregnancy outcome of patients. [ABSTRACT FROM AUTHOR]

Copyright of Journal of International Reproductive Health/Family Planning is the property of Editorial Board of the Journal of International Reproductive Health/Family Planning and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Southeast University / Dongnan Daxue Xuebao is the property of Journal of Southeast University Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: Combination of ascender and lander and ascender of Change’ E-5(CE-5) detectors successively landed on the moon successfully. The mission and landing modes of these two detectors are different, so we use different methods to determine their landing positions. Methods: The lunar positions are obtained with the combined the data from unified X-band (UXB) tracking network and very long baseline interferometry (VLBI) network. The method of joint statistical positioning is investigated to determine CE-5 combination of ascender and lander. Although data precision between the data-transmission signal and side-tone signal of differential of range (DOR) is marked, their effects on the positioning are not significant. Longer scale of observation data help improving the position precision, but the total length of 1 h satisfies the accuracy requirements. Results: The kinematic statistical method by polynomial fitting is used to determine the landing trajectory and the lunar position of CE-5 ascender, and is compared with the point positioning method. Their differences are better than 40 m. The landing moment of CE-5 ascender is also calculated to millisecond accuracy. Conclusions: Our method will provide a valuable reference for the lunar positioning of detectors in the future phase IV of Chinese lunar project. [ABSTRACT FROM AUTHOR]

Objective To investigate the optimal preparation method of bisphenol A (BPA) -induced diminished ovarian reserve (DOR) rat models, and to clarify the attributes of traditional Chinese medicine (TCM) syndromes. Methods Eighteen clean female SD rats aged 3 and 6 months with regular estrous cycle were selected and were randomly divided into the low-dose, medium-dose and high-dose BPA groups. The rats in the low-dose, medium-dose and high-dose BPA groups were given 50，100，and 200 mg/kg BPA mixed suspension orally, once a day until they showed unregular estrous cycles. The general performance and vaginal smear were observed everyday. The estrous cycle of rats was observed by vaginal smear; the abdominal aortic blood of rats was collected, and serum was separated. Serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), anti-Müllerian hormone (AMH), and inhibin-B (INHB) were detected by ELISA. We took bilateral ovaries, observed the morphology of ovarian tissues, and calculated the proportion of follicles at all levels and the ovarian index. We chose the model preparation method used in the group which had the most significant change of the indexes as the best method. The 18 successful model rats were randomly divided into the control group, Yougui pill group, and Yangjingzhongyu decoction group, with 6 in each. The model rats in the control group， Yougui pill group and Yangjingzhongyu decoction group were given distilled water, Yougui pill for treatment of kidny-yang deficiency, and Yangjingzhongyu decoction for kidny-yin deficiency by 1 mL/100 g body weight, for 2 consecutive weeks， respectively. The changes of estrous cycle, symptoms of kidney-yang deficiency, ovarian tissue morphology, ovarian index, proportion of follicles at all levels, serum hormone, INHB and AMH levels were compared between these two groups. Results All model rats in the BPA groups aged 3 and 6 months had reduced activity and liked to crouch and bunch. The disturbance time of estrous cycles of model rats aged 3 month in the medium-dose BPA group was significant shorter as compared with that of the other groups, and they showed decreased levels of AMH and primordial follicles and increased atretic follicles. Therefore, the preparation method in the 3-month-old rat model of the medium-dose BPA group was the best method. One rat in the Yangjingzhongyu decoction group and 5 rats in Yougui pill group resumed regular estrous cycle while all rats in the control group continued to be in disorder. The number of regular estrus cycle recovery in the Yougui pill group （5）was higher than that in the control group（0）and Yangjingzhongyu decoction group (1), while the symptom of kidneyyang deficiency improved more significantly. The ovaries of rats in the control group were pale, small and hard, while those of the Yougui pill group were bigger and ruddy. The ovaries of Yougui pill group had good elasticity and multiple growth follicles on the surface. There were fewer follicles on the ovarian surface and poor elasticity in the rats of Yangjingzhongyu decoction group. Compared with the other two groups, the Yougui pill group had higher proportion of primordium follicle, lower atresia follicle, and higher AMH level (all P<0. 05). Conclusions The DOR animal models can be successfully prepared by intragastric administration of 100 mg/kg BPA in 3-month clean SD rats. The attribute of TCM syndrome of the rat models is kidney-yang deficiency by means of syndrome differentiation through formula. [ABSTRACT FROM AUTHOR]

Objective To explore the association between idiopathic diminished ovarian reserve and thyroid autoimmunity (TAI). Methods After excluding the patients with known causes compromising diminished ovarian reserve (iatrogenic, genetic and other autoimmune diseases other than TAI), 348 eligible patients with detections of anti-Müllerian hormone (AMH), thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), thyroid per⁃ oxidase antibody (TPOAB) and thyroglobulin antibody (TGAB)on the same day were enrolled. These patients were then divided into two groups according to AMH value：the diminished ovarian reserve (DOR) group and the normal ovarian re⁃ serve (NOR)group. The levels of thyroid hormones and antibodies, and the prevalence of hypothyroidism and thyroglobulin autoantibody (TPOAb and TGAb) were compared between the DOR group and NOR group. According to the age, the patients were divided into three different age groups of low childbearing age (21-30 years), middle childbearing age (31- 35 years), and high childbearing age (36-40 years). The differences in the above indicators were compared between the two groups of different childbearing age groups. Results For the whole study population, no significant differences were found in the levels of thyroid hormones, antibodies or the prevalence of hypothyroidism and positive antithyroid antibody between the DOR group and NOR group (all P>0. 05). After age stratification, in the middle childbearing age group, the level of TSH in the DOR group was lower than that in the NOR group, and the positive rate of TPOAb was higher (both P< 0. 05). The effect of TPOAb positivity on ovarian reserve had statistical difference after adjusting for age and TSH level in the binary Logistic regression model (OR=3. 387, P<0. 05). Conclusion In the middle childbearing age group (31-35 years old), idiopathic DOR is related to high TPOAb positive rate. [ABSTRACT FROM AUTHOR]

Copyright of Geomatics & Information Science of Wuhan University is the property of Geomatics & Information Science of Wuhan University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Clinical Hepatology / Linchuang Gandanbing Zazhi is the property of Journal of Clinical Hepatology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

OBJECTIVE: To probe into the effects of Zishen Tiaochong method and growth hormone on outcome of in vitro fertilization and embryo transfer (IVF-ET) in women with diminished ovarian reserve (DOR) at different age. METHODS: Pregnancy outcomes of 217 patients with DOR undergoing IVF-ET in Guangdong Women and Children Hospital from Jan. 2017 to Jan. 2019 were analyzed retrospectively, including 105 patients < 35 years old and 112 patients ≥35 years old. All patients were on antagonist regimens and were on the first cycle of superovulation. In each age group, according to different pretreatment methods, all patients were divided into the traditional Chinese medicine group, the GH group and the control group. The traditional Chinese medicine group was given intervention of Zishen Tiaochong method, the GH group was pretreated with GH, and the control group was not pretreated with TCM or GH. Differences in clinical and laboratory indexes and pregnancy outcomes were observed in the three groups within the two age groups. RESULTS: There was no significant change in ovarian response and clinical outcome in patients with DOR aged <35 years old after GH intervention. The thickness of intrauterine membrane on the day of transplantation, number of harvested eggs and two prokaryotes (2PN) fertilization rate of the traditional Chinese medicine group were slightly higher than those of the GH group and the control group, but the difference was not statistically significant (P>0. 05). For patients with DOR aged ≥35 years old, the total application time and total dose of Gonadotropin (Gn) in the CH group were significantly lower than those in the traditional Chinese medicine group and the control group; the optimal embryo rate in the GH group was significantly higher than that in the traditional Chinese medicine group and the control group, with statistically significant difference (P<0. 05). Regardless of patients aged ≥35 years old or aged <35 years old, the endometrial thickness of patients in the traditional Chinese medicine group was the lowest during menstruation, which was significantly different from the GH group and the control group (P<0. 05). Within the two age groups, there was no statistically significant difference in the implantation rate, pregnancy rate and clinical pregnancy rate in the traditional Chinese medicine group, CH group and the control group, the difference was not statistically significant (P>0. 05). CONCLUSIONS: The intervention of GH in the elderly (≥35 years old) patients with DOR can improve the ovarian reactivity to a certain extent, while Zishen Tiaochong method is more effective in younger (< 35 years old) patients with DOR, and Zishen Tiaochong method can promote the endometrium spallation during menstruation and increase the endometrium thickness on the day of transplantation. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Modern Medicine & Health is the property of Journal of Modern Medicine & Health and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)