DOR患者自然周期体外受精应用 GnRH⁃a 扳机对胚胎实验室技 术指标的影响.

Objective：To investigate the effect of gonadotropin ⁃ releasing hormone agonist（GnRH ⁃ a）trigger on the laboratory technical indicators of embryos during natural cycle in vitro fertilization（IVF）in patients with diminished ovarian reserve（DOR). Methods：A retrospective study was conducted to analyze the data of patients with DOR who underwent natural IVF cycles in the Reproductive Medicine Center of the Affiliated Obstetrics and Gynaecology Hospital of Nanjing Medical University from January 1, 2018 to April 30, 2023. According to whether the GnRH⁃a trigger was used, the patients were divided into the trigger group and the non⁃trigger group, with 300 cycles in the trigger group and 47 cycles in the non⁃trigger group. A 1∶3 propensity score matching（PSM） was performed to compare the total number of oocytes retrieved, transferable embryos, high⁃quality embryos normal fertilization rate, oocyte utilization rate, high⁃quality embryos rate, and non⁃retrieved oocytes rate between the two groups. Results：A total of 165 cycles were included the（46 cycles in the non⁃trigger group and 119 cycles in the trigger group）after PSM, and the high⁃quality embryo rate in the trigger group was higher than that in the non⁃trigger group（61.1% vs. 35.0%, P=0.045). There were no significant differences in the total number of oocytes retrieved, the number of transferable embryos, the number of high⁃quality embryos, the normal fertilization rate, the oocyte utilization rate, and the non⁃retrieved oocyte rate between the two groups（all P > 0.05). Conclusion：The use of GnRH⁃a trigger during the natural cycle can improve the rate of high⁃quality embryos in patients with DOR. [ABSTRACT FROM AUTHOR]