To observe the clinical efficacy and effects of Baofei ointment for maintenance treatment of advanced non-small cell lung cancer (NSCLC). 48 patients with stage III~IV NSCLC who were hospitalized in Liaoning Cancer Hospital, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, and Second Hospital of Shenyang Second Traditional Chinese Hospital from October 2017 to October 2018 patients with tumor who have entered the maintenance treatment stage after first-line chemotherapy were divided into two groups according to the random number table method. Months according to the RECIST criteria for the evaluation of the efficacy of solid tumors to evaluate the effect of the lesions, comparing the disease control rate, KPS score before and after treatment, weight, TCM symptoms, immune function changes and the occurrence of side effects in the two groups. The DCR rate of the control group was slightly lower than that of the observation group at 2, 4, 6, 8, 10, 12, and 14 months after treatment (P>0.05). After treatment, the total improve- ment rate of KPS score in the observation group after treatment was 91.67 %, and the total improvement rate in weight change was 93.75 %, which were significantly higher than those in the control group (62.50 %, 66.67 %, P<0.05). The TCM symptom score of the two groups after treatment were significantly lower than before treatment (P<0.05), and the observation group was significantly lower than the control group (P<0.05). The total effective rate of the observation group was 83.33 %, significantly higher than the control group (45.83 %, P<0. 05). After treatment, the CD3+ and CD4+ cell counts and CD4+ /CD8+ values in the peripheral blood T lymphocyte subsets of the two groups were significantly higher than before treatment (P<0.05), and the above indicators in the observation group were significantly higher than the control group (P<0.05), although the CD8+ cell count in T lymphocyte subsets was slightly higher than before treatment, the difference between the groups was not statistically significant (P>0.05). The incidence of neutropenia and nausea and vomiting in the control group was higher than that in the observation group (P<0.05), and there was no difference between the two groups in the incidence of thrombocytopenia and diarrhea (P>0.05). Baofei cream could better control the development of NSCLC, improve the clinical symptoms, improve the immunity, and have no obvious toxic and side effects after long-term use. [ABSTRACT FROM AUTHOR]