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Copyright of Transportation Science & Technolgy is the property of Transportation Science & Technology Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

To observe the clinical efficacy and effects of Baofei ointment for maintenance treatment of advanced non-small cell lung cancer (NSCLC). 48 patients with stage III~IV NSCLC who were hospitalized in Liaoning Cancer Hospital, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, and Second Hospital of Shenyang Second Traditional Chinese Hospital from October 2017 to October 2018 patients with tumor who have entered the maintenance treatment stage after first-line chemotherapy were divided into two groups according to the random number table method. Months according to the RECIST criteria for the evaluation of the efficacy of solid tumors to evaluate the effect of the lesions, comparing the disease control rate, KPS score before and after treatment, weight, TCM symptoms, immune function changes and the occurrence of side effects in the two groups. The DCR rate of the control group was slightly lower than that of the observation group at 2, 4, 6, 8, 10, 12, and 14 months after treatment (P>0.05). After treatment, the total improve- ment rate of KPS score in the observation group after treatment was 91.67 %, and the total improvement rate in weight change was 93.75 %, which were significantly higher than those in the control group (62.50 %, 66.67 %, P<0.05). The TCM symptom score of the two groups after treatment were significantly lower than before treatment (P<0.05), and the observation group was significantly lower than the control group (P<0.05). The total effective rate of the observation group was 83.33 %, significantly higher than the control group (45.83 %, P<0. 05). After treatment, the CD3+ and CD4+ cell counts and CD4+ /CD8+ values in the peripheral blood T lymphocyte subsets of the two groups were significantly higher than before treatment (P<0.05), and the above indicators in the observation group were significantly higher than the control group (P<0.05), although the CD8+ cell count in T lymphocyte subsets was slightly higher than before treatment, the difference between the groups was not statistically significant (P>0.05). The incidence of neutropenia and nausea and vomiting in the control group was higher than that in the observation group (P<0.05), and there was no difference between the two groups in the incidence of thrombocytopenia and diarrhea (P>0.05). Baofei cream could better control the development of NSCLC, improve the clinical symptoms, improve the immunity, and have no obvious toxic and side effects after long-term use. [ABSTRACT FROM AUTHOR]

Objective To investigate the clinical efficacy and safety of liposome paclitaxel in maintenance therapy of advanced squamous cell lung carcinoma patients. Methods After 4-6 cycles of first-line treatment, 57 patients with advanced squamous cell lung carcinoma were randomized into liposomal paclitaxel monotherapy maintenance treatment group(experimental group, n=29) and follow-up observation group(control group, n=28). Efficacy and side effects were observed in experimental group. PFS and OS were compared between two groups. Results CR, PR, SD, PD rates of experimental group were 0, 13.8%, 44.8%, 41.4%, and disease control rate(DCR) was 58.6%. The major toxicities were myelosuppression and gastrointestinal reactions. PFS and median survival time(MST) of two groups were 5.7 vs. 2.4 months and 7.3 vs. 4.9 months(both P < 0.05). The patient's quality of life(QOL) was better in experimental group, compared with control group. Conclusion As a maintenance therapy after the first-line treatment of advanced squamous cell lung carcinoma, liposomal paclitaxel could significantly improve PFS, OS and QOL of patients, and the adverse reactions are tolerable.

Copyright of Practical Oncology Journal is the property of Journal of Practical Oncology Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the proportion of drug abuse of methadone maintenance treatment (MMT) objects and to identify its related factors. Methods A total of 1 960 MMT objects in 14 MMT clinics in Shanghai were recruited to participate in a cross-section study. Questionnaire including demographic information, drug abuse and MMT information were surveyed. Urine sample was collected to conduct multi-drug test as a biological marker to identify morphine, methamphetamine (crystal meth), marijuane, methylenedioxy methamphetamine (ecstasy), and ketamine (specieal K) abuse. Results The average age of the 1 960 objects was (49.3±8.7) years old. The average duration of drug abuse was (19.0±6.0) years. About 23.3% of all the objects self-reported they had used club drug before, and 7.1% had abused drug in the past one month. Urine test showed that among the 1 960 objects, 9.1% had abused morphine, 3.7% had abused methamphetamine, 0.1% had abused ketamine, 0.3% had abused ecstasy and 0.2% had abused marijuana. Multiple logistic regression analysis showed that group of negative attitude towards club drug offered by friends had lower risk of abusing morphine (OR=0.23, 95%CI: 0.14-0.39) and club drug (OR=0.08, 95%CI: 0.05-0.15). The group of no contacts with drug abuse companion (OR=0.59, 95%CI: 0.40-0.87) and not having dropped out during MMT (OR=0.44, 95%CI: 0.30-0.64) had lower risk of abusing morphine. Compared with group of having good relationship with family and having daily methadone dose of 0-39 mL, the group of having ordinary relationship with family (OR=2.40, 95%CI: 1.17-4.92) and having daily methadone dose of 40-59 mL (OR=1.96, 95%CI: 1.05-3.65) had higher risk of abusing morphine. Compared with group of attending MMT for less than 3 years, the group of attending MMT for 4-6 years had lower risk of abusing morphine (OR=0.51, 95%CI: 0.31-0.82) and club drug (OR=0.41, 95%CI: 0.17-0.97). Conclusions Drug abuse of morphine and club drug were common during MMT clinics in Shanghai, and is related with the family, contacts with drug abuse companion, drop out during MMT, and years eurolled in MMT. Pertinence publicity and behavioural intervention should be undertaken to reduce drug abuse in MMT objects. [ABSTRACT FROM AUTHOR]

Lung cancer is the leading cause of death from cancer in the world. The treatment remains one of the most challenging tasks in the medical world. The discovery and development of epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) have had a major impact in the treatment of non small cell lung cancer (NSCLC). But the efficacy of EGFR-TKI in EGFR wild-type patients is limited, and the limited EGFR mutation incidence also prompts researchers to study what is the best treatment choice for patients with NSCLC who are negative for EGFR mutations. This review will discuss the research status in treatment choice for EGFR wild-type NSCLC.

Multiple myeloma is a monoclonal plasma cell malignant proliferative disease，accounting for about 10% of malignant tumors of blood system. In recent years， due to the application of hematopoietic stem cell transplantation and the application of MDT by combining new drug such as thalidomide, lenalidomide and bortezomib, the average survival of MM patients was significantly longer than before. The treatment strategy should be individualized before treatment according to the patient's age，physical condition and complications. In this paper, the treatment strategy of multiple myeloma patients were reviewed. [ABSTRACT FROM AUTHOR]

Objective: To investigate the clinical efficacy of ginsenoside Rg3 in maintenance treatment of patients with advanced non-small cell lung cancer(NSCLC) after chemotherapy. Methods: A total of 120 patients with advanced NSCLC, who were treated with the first-line chemotherapy and without progression disease in Affiliated Hospital of Chengdu University of Traditional Chinese from November 2010 to November 2014, were selected and randomly divided into experiment group(n=60) and control group(n=60). The control group was only regularly followed up and observed, while the experiment group was maintained with ginsenoside Rg3. Then the clinical efficacy, the changes of immune indexes and the quality of life before and after treatment and the incidence of adverse reactions in the two groups were compared. Results: The disease control rate(DCR) of experimental group was obviously higher than that of control group(P<0.05). The immune indexes of two groups after treatment were lower than before treatment, meanwhile, the indexes of experimental group were significantly higher than those of control group(P<0.05). The improvement rate of KPS score in the experimental group after treatment was significantly higher than that in the control group(P<0.05). There was no treatment-related death during the whole maintenance treatment. Conclusion: Using ginsenoside Rg3 in the maintenance treatment of patients with advanced NSCLC after chemotherapy can improve the immune function and increase the quality of life, with good safety and efficacy,which is worthy of clinical promotion. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Lung Cancer is the property of Chinese Journal of Lung Cancer and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To comprehensively evaluate the long-term efficacy and safety of coated metal stent implantation for ureteroscopic lithotripsy related refractory ureteral stricture (URL-rUS)., Methods: Electronic medical records of 30 patients (31 affected renal units) receiving coated metal stent implantation for URL-rUS from Sept. 2018 to Aug. 2021 at Peking University People' s Hospital were reviewed for analysis. Coated metal stents were implanted in retrograde approach via ureteroscope. Last outpatient follow-up was set as endpoint. Baseline information, stricture characteristics and decompression strategy before coated metal stent implantation were retrospectively collected. Serum creatinine (Scr) concentration and renal pelvis width (RPW) were used as renal function indicators. Peri-operative and long-term complications and according outcomes were recorded. For the patients who had double J tubes implanted for drainage before operation, Ureteral Stent Symptom Questionnaire (USSQ) was applied to evaluate the stent-related discomforts and quality of life (QoL) before and after surgery. Data analysis was conducted with SPSS (version 25.0; SPSS, Chicago, IL, USA)., Results: Totally 30 patients with 31 affected renal units were included. All the patients previously underwent unsuccessful traditional endoscopic balloon dilation or endoureterotomy before receiving coated metal stent implantation. The mean age was (45.5±9.3) years old. The median follow-up time were 14 (6-36) months. All coated metal stents were successfully placed with a median duration of 60 (30-195) min. No severe peri-operative complications occurred. At endpoint, 28 (90.3%) sides of coated metal stents remained unobstructed with a longest indwelling time of 36 months. Causes of failures included stent migration (1 case, 3.2%), encrustation (1 case, 3.2%) and repeated stent related urinary tract infection (1 case, 3.2%). When compared with the baseline, significant reductions were observed in both Scr concentration and RPW at endpoint [(90.7±19.5) mmol/L vs. (83.1±18.5) μmol/L, P < 0.01, for Scr; (2.5±1.3) cm vs. (1.9±0.8) cm, P < 0.01, for RPW], indicating good preservation of renal function and remission of hydronephrosis. For 26 patients with double J stents before operation, significant reduction of USSQ average score (100.4±6.6 vs. 82.1±4.9, P < 0.01) evidenced better life quality preserving ability of coated metal stent versus double J stent., Conclusion: Coated metal stent implantation is a safe and minimally invasive management of ureteral stricture providing a satisfying long-term patency rate, after which the patients' quality of life and renal function could be both improved. This method could serve as a promising alternative long-term maintenance treatment option for patients with URL-US, especially when traditional endoscopic interventions failed.

Objective To analyze the reasons of dropping out in the patients with methadone maintenance treatment and the population characteristics in order to adopt the corresponding intervention measures for increasing the retention rate and reducing the risk of HIV and HCV infection. Methods The accumulative 24 389 patients with methadone treatment in the monitoring data in the methadone maintenance treatment clinic of Chongqing City from 2007 to 2012 were collected, among them 10 572 cases of treatment dropping out were emphatically analyzed. Then the dropping out situation of methadone treatment in Chongqing City was statistically analyzed. Results A total of 24 389 cases of methadone maintenance treatment were accumulated during 2007-2012 in Chonqing City,including accumulative 10 572 cases of dropping out,the dropping out rate was 43.3%. The top five of dropping out reasons were respectively no treatment for 7 d without causes, unable to contact, disease/pregnancy, out-migration for work/on business/doing business/migration/go abroad, illegal criminal activity and being caught without relation with drug;the patients of male,low cultural degree,short drug use time,treatment dose<60 mg/d were more likely to quit the methadone maintenance treatment;the HIV and HCV infection rates in the dropping out crowds were 4.0% (428/10 572) and 65.9% (6 962/10 572) respectively,in which the HIV/HCV merge infection rate was 3.1% (328/10 572),accounting for 76.6% (328/428) of HIV infection people. Conclusion The dropping out rate of methadone maintenance treatment in Chongqing City from 2007 to 2012 is higher,the HCV infection situation in the dropping out crowds is serious. The intervention on the drug users of male,low cultural level,short drug use time and low treatment dose should be strengthened in order to increase the retention rate of methadone maintenance treatment and decrease the infection risk. [ABSTRACT FROM AUTHOR]

Objective: To explore the status of glucocorticoid application in patients with systemic lupus erythematosus (SLE) in China. Methods: Epidemiological survey was used. The SLE patients who met the 1997 classification criteria of American College of Rheumatology were enrolled. The usage of glucocorticoid and related adverse reactions were recorded and analyzed. Results: A total of 400 SLE patients were enrolled, including 35 men and 365 women. The average age was (37.4±14.0) years old, and the average duration of disease was (6.7±5.8) years. There were 310 patients using glucocorticoid as maintenance. Sixty-one percent ( n =244) patients started using medium dose (prednisone 30-<60 mg/d) as the initial treatment of glucocorticoid, which lasted for(37±11)days.The time of drug duration in patients with low dose prednisone (7.5-<30 mg/d)and high dose (60-100 mg/d) was(92±20)and(17±3)days respectively ( P <0.05 between 3 groups). However, patients receiving different initial dosage were of no discrepancy in the maintenance therapy. During maintenance, even though 51.0% ( n =158) patients were on prednisone 2.5-5 mg/d, the duration of drug use in >5-10 mg/d groupwas longer[(29.9±3.3) months]. Patients with involvement of internal organs had a higher tendency to use 60-100 mg/d prednisone or pulse-dose therapy in the initial treatment, nevertheless these two groups had no difference of maintenance dosage. Among all 400 patients, 62 patients withdrew glucocorticoid, including 17 patients with disease remission (4.3%), 44 by self-withdrawal and one with adverse reaction. Conclusion: In China, the medium dosage of glucocorticoid is the most common initial treatment in patients with SLE.Prednisone 2.5-5 mg/d was the most common choicefor maintenance therapy. Currently, the proportion of glucocorticoid withdrawal remains low in SLE patients achieving remission.