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BackgroundSchizophrenia patients often face high level of stigma and low level of self-esteem， significantly hindering their recovery. Mindfulness-based intervention has proven be effective in reducing stigma and improving self-esteem. However， traditional mindfulness intervention typically involve high costs and require long-term professional involvement.ObjectiveTo explore the effects of blended mindfulness interventions on stigma and self-esteem in patients with stable schizophrenia， so as to provide references for reducing stigma， enhancing self-esteem and promoting recovery.MethodsPatients receiving outpatient treatment at the Third Hospital of Daqing from June 2022 to January 2023， who met the diagnostic criteria for schizophrenia in the International Classification of Diseases， tenth edition （ICD-10） and were in a stable phase， were recruited for the study （n=84）. According to the random number table method， participants were randomly assigned to study group and control group， with 42 cases in each group. Both groups received treatment with the second-generation antipsychotic medications， while the study group additionally received blended mindfulness intervention for 8 weeks， with sessions lasting 45~60 minutes， three times a week. Both groups were evaluated with Five Facet Mindfulness Questionnaire （FFMQ）， Internalized Stigma of Mental Illness Inventory （ISMI） and Rosenberg Self-Esteem Scale （RSES） at baseline and after 8-week intervention. Covariance analysis was used to compare the FFMQ， ISMI and SES scores between two groups after 8-week intervention.ResultsAfter 8-week intervention， there were statistically significant differences between two groups in total FFMQ scores， as well as in the observation， acting with awareness， non-judgment and non-reactivity subscale scores （F=50.680， 12.952， 13.567， 22.799， 14.043， P

[Objective] Accurately forecasting energy demand and carbon emissions is the key to realize carbon peaking and neutrality. However, how to manipulate scenario measures to change the Environmental Kuznets Curve (EKC) inflection point, which signifies the timing of carbon peaking, remains a crucial research topic. As the forefront of China’s economy, it is of great guiding value for Zhejiang Province to explore its peak carbon dioxide emissions turning point and path. [Methods] This paper constructs a localized LEAP-Zhejiang model, designs baseline and comprehensive scenarios, and simulates energy consumption and greenhouse gas emissions in various sectors such as residential life, transportation, industry, agriculture, services, and energy conversion in Zhejiang Province from 2020 to 2050, and pays special attention to the impact of policies on the turning point of EKC. [Results] (1) Under the comprehensive scenario, the greenhouse gas emissions of Zhejiang Province will be greatly reduced during the forecast period compared with the baseline scenario, and will reach the peak in 2029. The emission intensity is significantly reduced to only 17.65% of the baseline scenario. This remarkable improvement is primarily attributed to the proactive transformation of the energy structure, successfully shifting from a coal and oil-dominated baseline scenario to an electricity-dominated comprehensive scenario. (2) The green energy sector sub-scenario emerges as the primary driving force for emissions reduction, delivering notable contributions through the green transformation of the energy structure. While the industrial sector remains a significant player in emissions reduction, its contribution rate is declining year by year. In contrast, the tertiary industry, particularly the transportation sector, is experiencing a steady increase in its energy-saving and emission-reduction contribution rate, showcasing a positive trend towards green transformation. (3) The popularization of new energy vehicles has been proved that it can effectively change the position of inflection point of EKC and achieve inflection point crossing, intuitively reflecting the positive effect of this measure in accelerating the arrival of carbon peaking in the province. [Conclusion] Zhejiang Province can adopt three major strategies to address climate change. Firstly, optimize the energy structure by increasing the proportion of renewable energy and constructing an intelligent energy system. Secondly, promote new energy vehicles by providing policy support and charging facilities to lead the way towards green transportation. Thirdly, enhance public environmental awareness, support carbon sequestration technologies, and encourage afforestation and low-carbon lifestyles.

Vascular cognitive impairment (VCI) denotes a wide range of cognitive deficiencies resulting from cerebrovascular risk factors and cerebrovascular diseases. Sirtuin 1 (SIRT1), as a deacetylase, can mediate the deacetylation of histones and non-histone proteins. It is involved in regulating multiple pathophysiological processes of VCI, including neuroinflammation reduction, oxidative stress inhibition, cell apoptosis decrease, and blood-brain barrier protection, serving as a target for VCI treatment. This paper summarizes SIRT1 and the molecular mechanisms of targeting SIRT1 in order to provide a reference for the clinical treatment of VCI.

Stroke is a common neurological disease. Post-stroke sensory disorder is one of the common complications of stroke， which has severe negative impact on motor function and activity participation of patients. Transcranial direct current stimulation （tDCS）， a technique that uses 1 to 2 mA of direct current to modulate the cerebral cortex， is non-invasive， safe and well tolerated by patients. This study elaborates on the theoretical basis and mechanism of action of tDCS in treating post-stroke sensory disturbances， and analyzes and summarizes the application of tDCS in post-stroke sensory disturbances， confirming the effectiveness of tDCS， providing strong support for further clinical research of tDCS in the field of post-stroke rehabilitation.

Objective To investigate the clinical characteristics of patients with coronary artery spasm (CAS) combined with obstructive stenosis and the impact of stent implantation on their prognosis. Methods A retrospective observational study was conducted on patients admitted to Nanjing Jiangbei Hospital from June 2009 to June 2021, diagnosed with coronary artery spasm syndrome (CASS). Based on the results of coronary angiography (CAG), patients were divided into two groups: those combined with obstructive stenosis (n=24) and those without obstructive stenosis (n=20). The efficacy of medical treatment or combined stent implantation was observed, and major adverse cardiovascular events (MACE) or death were monitored during follow-up. Results There were no statistically significant differences between the group CAS combined with obstructive stenosis and the group CAS without obstructive stenosis in terms of gender, age, risk factors (hypertension, diabetes, alcohol abuse, smoking), laboratory test indicators ［peak values of blood glucose (Glu), low-density lipoprotein cholesterol (LDL-C),total cholesterol］, myocardial injury markers ［cardiac troponin T (cTnT), creatine kinase isoenzyme (CK-MB)］, ejection fraction (EF), and proportion of inferior wall ST segment elevation on electrocardiogram (P>0.05). Among 24 cases of spastic coronary artery complicated with obstructive stenosis, 5 cases (20.83%) were treated with drugs, and 19 cases (79.17%) underwent PCI ［15 cases (78.95%) had PCI on spastic and obstructive stenostic coronary arteries and 4 cases (21.05%) had PCI on non-spastic coronary arteries］. Among 20 cases of spastic coronary artery without stenosis, 16 cases had right coronary artery (RCA)spasm (including 13 cases had RCA completely normal with spasm, 3 cases with 20%-30% stenosis), 4 cases of left anterior descending artery (LAD) spasm (2 cases of completely normal, 2 cases with 30%-40% stenosis), and only 1 case (5.00%) underwent PCI in non-spastic coronary artery. in the group with coronary artery spasm and obstructive stenosis, the follow-up period ranged from 24 to 129 (64.13±29.80) months, with 4 cases of angina recurrence, 1 case of in-stent stenosis, and 1 case of very late stent thrombosis leading to acute myocardial infarction requiring emergency PCI. In the group without stenosis, the follow-up period ranged from 30 to 168 (64.75±32.54) months, with 7 cases of angina recurrence and 1 death. The incidence of MACE (25.00% vs40.00%) was not statistically significant between the two groups (P＞0.05). Conclusion Patients with CAS and obstructive stenosis can choose medical treatment combined with stent implantation for good prognosis, but guidance under intracoronary imaging is necessary.

Objective To investigate the related influence factors of neonatal transfusion-associated necrotizing enterocolitis （TANEC）. Methods Clinical data of neonates with necrotizing enterocolitis （NEC） treated by surgery were retrospectively analyzed. All participants were divided into the TANEC and non-TANEC groups. Clinical characteristics， maternal conditions， laboratory test results， intraoperative conditions and clinical prognosis were subject to univariate and multivariate Logistic regression analyses. Related factors of TANEC were identified. The predictive values of these factors were determined by the receiver operating characteristic （ROC） curve and the area under the ROC curve （AUC）. Results A total of 51 infants were enrolled in this study， including 13 cases in the TANEC group and 38 in the non-TANEC group. Univariate analysis showed statistically significant differences in birth weight， Apgar-1 score， gestational age， number of transfusions， patent ductus arteriosus and hemoglobin level between two groups （all P < 0.05）. Multivariate Logistic regression analysis revealed that the number of transfusions and hemoglobin level were the related factors for the incidence of TANEC （both P < 0.05）. ROC curve verified that the AUC of the number of transfusions was 0.882 （95% CI 0.794-0.969）， 0.857 （95% CI 0.747-0.968） for hemoglobin level， and 0.907 （95% CI 0.822-0.992） for the two combined， respectively. Conclusion The number of blood transfusion and hemoglobin level are associated with the occurrence of TANEC， and the combination of these two can better predict the incidence of TANEC.

Dysphagia is a common complication after stroke, and early screening, correct assessment, and timely intervention can improve patient outcomes. This article reviews the research progress affecting the outcomes of patients with stroke dysphagia from the aspects of swallowing function screening and evaluation, and feeding management. (吞咽障碍是脑卒中患者常见并发症, 早期筛查、正确评估、及时干预可改善患者结局。本文从吞咽筛查和评估、进食管理等内容对影响脑卒中吞咽障碍患者结局的研究进展进行综述。)

BackgroundCompared with male adolescents， depression among female adolescents is of higher prevalence and greater severity. The level of generalized trust correlates with the severity of depression， and attachment correlates with the level of generalized trust. Therefore， based on the mediating role of generalized trust between attachment and depression， this study explores the pathogenesis of depression in female adolescents.ObjectiveTo explore the mediating role of generalized trust between paternal， maternal and peer attachment and depression in female adolescents， so as to provide references for improving the depression of female adolescents.MethodsThis study included 73 female adolescents who met the diagnostic criteria for depressive disorder in the International Classification of Diseases， tenth edition（ICD-10） as well as received outpatient and inpatient treatment in Hangzhou Seventh People's Hospital between March 2022 and October 2022. Investigation was conducted by use of Revised Inventory of Parent and Peer Attachment （IPPA-R）， the Inclusive General Trust Scale （IGTS） and Children's Depression Inventory （CDI）. Pearson correlation analysis was used to explore the correlation between each scale score. The Bootstrap method was used to test the mediating role of generalized trust between attachment and depression.Results① CDI score in female adolescents with depression was negatively correlated with scores of paternal， maternal and peer attachment in IPPA-R （r=-0.463， -0.459， -0.447， P

Penicillium expansum, a common spoilage organism in postharvest fruits, can cause fruit decay and deterioration and endanger human health. It is of great significance to investigate the antimicrobial mechanism of the antimicrobial peptide from Paenibacillus ehimensis on P. expansum spores. The antimicrobial activity of the antimicrobial peptide against P. expansum spores was determined by using the two-fold dilution method as well as measuring the time-killing curve. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) were used to evaluate the effect of the antimicrobial peptide on the ultrastructure of P. expansum spores. The effects of the antimicrobial peptide on the cell membrane and reactive oxygen species (ROS) accumulation of P. expansum were analyzed by fluorescence probes. The results showed that the minimum inhibitory concentration (MIC) of the antimicrobial peptide against P. expansum spores was 3.5 AU/mL. The spore germination rate was significantly decreased by 28.30%, 84.57% and 100% by the antimicrobial peptide at concentrations of 0.5 MIC, 1 MIC and 2 MIC compared with the blank control (P < 0.05). After treatment with the antimicrobial peptide, the spores appeared seriously sunken, the intracellular contents were leaked out, and the morphology and structure were changed. The antimicrobial peptide damaged the cell wall of P. expansum, resulting in the leakage of alkaline phosphatase. The antimicrobial peptide depolarized the cell membrane potential in a dose-dependent manner, and increased the cell membrane permeability, leading to K+ leakage. The fluidity of the cell membrane was increased, which in turn resulted in a significant decrease in DPH fluorescence intensity (P < 0.05). The integrity of the cell membrane was damaged by the antimicrobial peptide, so the fluorescence intensity of SYTOX-Green and the contamination rate of PI were increased. Moreover, the antimicrobial peptide at 1 MIC and 2 MIC increased the fluorescence intensity of DCFH-DA significantly (P < 0.05) and resulted in ROS accumulation, which affected the physiology and metabolism of P. expansum spores. This study indicated that the target sites of the antimicrobial peptide against P. expansum spores were mainly the cell membrane and ROS metabolism.

Objective: Ferroptosis may be an important mechanism of high glucose and high fat-induced pancreatic β cell death. This study investigated the effect and mechanism of grape seed procyanidin extract (GSPE) on ferroptosis in pancreatic β cells induced by high glucose and high fat. Methods: An islet β cell injury model was established by treating MIN6 cells with 25 mmol/L glucose and 200 μmol/L sodium palmitate. Then, the cells were transfected with nuclear factor erythroid 2-related factor 2 small-interfering RNA (Nrf2 siRNA) and treated with 10, 20, 30, 40, 50, 75 and 100 mg/L GSPE. The cell activity was detected by the cell counting kit-8 (CCK8) assay, and the levels of intracellular glutathione (GSH), malonaldehyde (MDA) and reactive oxygen species (ROS) were detected by commercial kits. The protein expression of Nrf2, heme oxygenase-1 (HO-1), NADPH:quinone oxidoreductase-1 (NQO1), iron metabolism indicator transferrin receptor 1 (TfR1), divalent metal transporter 1 (DMT1), ferritin, solute carrier family 7 member 11 (SLC7A11), glutathione peroxidase 4 (GPX4) and acyl-CoA synthetase long-chain family member 4 (ACSL4) were measured by Western blot. Results: Compared with the control group, high glucose and high fat caused intracellular iron deposition, up-regulated the protein expression levels of TfR1, DMT1 and ferritin, increased the levels of MDA, ROS and ACSL4, decreased the level of GSH and down-regulated the protein expression levels of GPX4 and SLC7A11. Intervention with GSPE could activate the Nrf2 signaling pathway to up-regulate GPX4 and SLC7A11 protein expression and increase the level of GSH. GSPE could also decrease the levels of MDA, ROS and ACSL4 and iron metabolism indices (TfR1, DMT1 and ferritin protein expression), thereby preventing ferroptosis in MIN6 cells induced by high glucose and high fat. After?inhibition of the Nrf2 signaling pathway?by?Nrf2-siRNA?transfection, the protective effect of GSPE was inhibited and the expression of the antioxidant enzymes HO-1, GPX4 and SLC7A11 was decreased. Conclusion: GSPE reduces ferroptosis induced by high glucose and high fat possibly by activating the Nrf2 signaling pathway and up-regulating antioxidant enzymes, consequently improving the cell viability of MIN6 cells.

Focusing on the issue of error detection in terminal guidance radar under sea clutter background, research on sea clutter suppression and discrimination is conducted. The target identification and classification algorithm based on Tri-feature training is adopted, and the target amplitude, peak duration range and fluctuation rate are used as feature quantities. The radial basis function (RBF) is selected as the kernel function, which has strong nonlinear mapping ability and can better represent the relationship between data in high-dimensional space. Then, the support vector machine ( SVM) target identification and classification classifier design and experimental data verification are carried out. Verified by publicly available measured data, the accuracy rate of the proposed algorithm has reached over 97%. Compared with the traditional template matching recognition method, the target identification and classification algorithm based on Tri-feature training has higher identification accuracy, which proves the effectiveness and progressiveness of the proposed method. [ABSTRACT FROM AUTHOR]

Dental resin materials have been widely used in the treatment of dental defects. However, the polymerization shrinkage of the resin materials tends to cause microleakage and accumulation of bacterial plaque, which leads to secondary dental caries. Endowing dental resin with antibacterial properties is an important way to solve this problem. Adding antibacterial agents to dental resin is the main method to give it antibacterial properties. Antimicrobial agents are mainly divided into three types: release type, non-release type and mixed type. In terms of antibacterial effects, the selection and addition of antibacterial agents will affect the antibacterial and mechanical properties of dental resin materials; and the long-term antibacterial effect of antimicrobial agents in the oral cavity remains to be verified; as antimicrobial agents or other environmental factors can lead to drug resistance and even dormant persistent bacteria. In recent years, researchers have been committed to improving the antibacterial effect by modifying antibacterial agents. The sustained release of antimicrobial agents via carriers is also the main research direction. This paper reviews the research progress on the antibacterial properties of dental resin materials.

To elucidate the mechanism of microbial inhibition on the formation of tobacco-specific nitrosamines (TSNAs), Bacillus flexus Ni3, a high-temperature-resistant strain capable of degrading nicotine with high efficiency, was isolated from cigar tobacco using the major precursors of TSNAs as the substrate. The inhibitory ability of strain Ni3 on TSNAs in cigar tobacco leaves was evaluated through shake flask culture experiments and simulated agricultural stack fermentation. The key genes involved in the degradation of TSNAs in strain Ni3 were identified by whole genome sequencing. The results showed that: 1) The nicotine degradation rate of strain Ni3 was 56% within 72 h in the nicotine fermentation medium with an initial nicotine mass concentration of 1.5 g/L. When the initial concentration of TSNAs was 10 mg/L, the degradation rates of NNN, NNK, NAT and NAB were 23%, 64%, 26%, and 27%, respectively. 2) Compared with the control group, the accumulation amounts of NNN, NNK, NAT and NAB on the 9th day of fermentation with Ni3 bacterial suspension decreased by 41%, 53%, 53% and 53%, respectively, and the total TSNAs decreased by 46%. 3) The whole genome sequencing analysis showed that there were 7 genes of strain Ni3 that might be involved in the degradation of TSNAs precursors. Therefore, B. flexus Ni3 has greater application potential in inhibiting the formation of TSNAs during the fermentation of cigar tobacco leaves. [ABSTRACT FROM AUTHOR]

Objective To explore the association between DLL3 expression and chemosensitivity of advanced SCLC patients to cis-platinum/etoposide therapy, and to evaluate the prognostic value of DLL3. Methods We selected 64 patients diagnosed as stage Ⅲ/Ⅳ SCLC. Protein levels of DLL3 were examined by immunohistochemistry. χ2 test was used to analyze the relation between DLL3 expression and chemotherapy efficacy. Kaplan-Meier and Cox multivariate analysis were used to investigate the impacts of DLL3 and other factors on PFS and OS of advanced SCLC patients. Results DLL3 was detected in 84.1% (54/64) of the samples and not associated with gender, age, smoking history or stage (P > 0.05). The response rate(RR) and disease control rate in DLL3-high group were lower than those in DLL3-low group (P < 0.05); PFS of patients with low DLL3 expression were better than those with high DLL3 expression (P < 0.05). DLL3 expression, tumor stage and tumor diameter were independent prognostic factors for PFS, and tumor stage was an independent prognostic factor for OS of advanced SCLC patients. Conclusion DLL3 is related to the response rate of EP chemotherapy and PFS. It may become a biomarker for predicting chemosensitivity. DLL3 has no predictive value for long-term prognosis of patients with advanced SCLC.

Professor Wei Qingqi is a well-known ecocritic scholar in China and currently teaches at the School of Foreign Languages, Southeast University. He has been engaged in environmental criticism, ecofeminist studies, gender studies, and literary translation for a long time, and has successively completed two national social science fund projects. He has published dozens of academic papers in authoritative domestic and foreign academic journals, and has published monographs on ecological criticism, such as Green-Clap Scholarship: An Interpretive Study of Ecocriticism (2010), Ecofeminism (2019), as well as dozens of translated works, including Going Away to Think(2010), When Women Were Birds (2021) and Oryx and Crake (2021). He has won the Excellent Achievement Award in Philosophy and Social Science of Jiangsu Province, Zijin Mountain Translation Award and the nomination for the Lu Xun Literature Prize in Translation. At the request of the editorial department of Poyang Lake Journal, Liu Dandan conducted an in-depth interview with Professor Wei Qingqi regarding the current status and the prospect of environmental humanities. In the interview, Professor Wei expects an outlook that ecocriticism will push us beyond the narrow and closed boundaries of humanities to think about our connections with the other-than-human realm. An environmental holism is the driving force for the sustainability of ecofeminism, and it is also the reasonable choice for social progressive movements that are determined to go onto a higher stage both at the theoretical and practical levels. Ecofeminism with a holistic critical approach will thereby play an even more active role in general literary and cultural studies. [ABSTRACT FROM AUTHOR]

A bacterial strain exhibiting antimicrobial activity was identified in farmland soil and screened using the transparent circle and agar diffusion methods. The strain was identified through morphological observation, physical and chemical analysis, and 16S rDNA sequence alignment, and the antimicrobial substances produced by the strain were identified using extracellular enzyme activity assay, protease hydrolysis, ammonium sulfate precipitation, membrane analysis, and stability analysis. The results showed that the identified strain was Lysobacter enzymogenes L-43, which demonstrated good antibacterial activity and no hemolysis. The antibacterial substances produced by L. enzymogenes L-43 had a broad antimicrobial spectrum and maintained a good inhibitory effect on Gram-positive bacteria. The diameter of the inhibition zone exceeded 10 mm. The antibacterial substances had no lysozyme activity and did not contain hydrogen peroxide. They were sensitive to protease E, protease K, pepsin, and trypsin, and the antibacterial activity recovery rate was 73.43%~79.00%. After membrane analysis, when the molecular weight cut-off of the dialysis bag was 3 500 u and 10 000 u, the antibacterial activity recovery rates were 93.43% and 59.82%, respectively. It was preliminarily determined that the antibacterial substances were mainly polypeptides with molecular weights between 3 500~10 000 u. The substances showed good thermal, acid-base, metal ion, chemical reagent, and storage stability, and the antibacterial activity recovery rate was 85.66% after treatment at 121 °C for 30 min. The antibacterial recovery rate was higher than 80% at pH 2~10, further confirming that the antibacterial substance was a polypeptide. In conclusion, the antibacterial substances produced by L. enzymogenes L-43 are stable peptides with a broad antibacterial spectrum. The findings of this study provide a foundation for the development of antibacterial strains and their metabolites. [ABSTRACT FROM AUTHOR]

Owing to the large radius of potassium ions, the SPAN cathode suffers large volume change during the cycling process, which causes structure collapse and serious capacity fade. Herein, the effects of sodium carboxymethyl cellulose (CMC) and polyvinylidene fluoride (PVDF) on the electrochemical performance of SPAN cathode in K-S battery were investigated, and the reason of CMC binder improving the electrochemical performance of SPAN cathode was further explored by kinetic test and SEM test. The rate performance test results showed that the SPAN electrode prepared by CMC binder displayed capacity of 1 256, 1 161, 1 058, 946, 716, 538 mAh/g at 0. 1C, 0. 2C, 0. 5C, 1C, 2C, 3C. And the capacity remained 1 253 mAh/g when the current density returns to 0. 1C, which was far better than the rate performance of SPAN electrode prepared by PVDF binder. Besides, the cycle performance test results showed that the SPAN electrode prepared by CMC binder could deliver a high reversible capacity of 822 mAh/g after 100 cycles at 0. 5C, corresponding to a high capacity retention of 75. 6%. The mechanism test results showed that benefit from the abundant oxygen-containing active functional groups in the CMC structure which could not only strengthen chemical interactions with active materials, alleviate the volume change of SPAN cathode during the charge/discharge process, but also accelerate the transport of potassium ion. The SPAN electrode prepared by CMC binder demonstrated a high rate performance and cycle performance compared to the case of PVDF binder. The finding of this study provided an effective strategy to restrain the volume expansion of potassium-sulfur batteries, to maintain the stability of the conductive network inside the electrode, thereby to improve the rate performance and cycle stability. [ABSTRACT FROM AUTHOR]

BACKGROUND: A large number of studies have confirmed that light therapy combined with sodium hyaluronate has a significant effect on knee osteoarthritis. The combination use is highly safe, but there is still lack of evidence-based evidence. OBJECTIVE: To perform a meta-analysis of light therapy combined with sodium hyaluronate for knee osteoarthritis. METHODS: English databases (PubMed, OVID, EMBASE} and Chinese databases (CNKI, WanFang, VIP, China Biomedical Literature Database) were retrieved by computer for relevant articles regarding randomized controlled trials of light therapy combined with sodium hyaluronate in the treatment of knee osteoarthritis. The search time was from the inception to July 1, 2019. The quality of the included studies was evaluated and relevant clinical data in the literature were extracted. The results were analyzed by RevMan 5.3. RESULTS AND CONCLUSION: A total of 16 articles were included, involving 1 505 patients. The experimental group was treated with light therapy combined with sodium hyaluronate, and the control group was treated with sodium hyaluronate. The meta-analysis results showed that compared with the control group, the experimental group showed higher total clinical effective rate (odds ratio (OR}=4.20, 95% confidence interval (Cl) [2. 75, 6.39], P < 0.000 01 ), higher cure rate (OR=2.62, 95%C/[1. 78, 3.86], P < 0.000 01 ), lower visual analogue scale score (mean difference (MD)=-1.51, 95%C/[-2.15, -0.87], P < 0.000 01), and better Lysholm score (MD=13.30, 95%C/[6.82, 19.78], P < 0.000 01 ). There was no significant difference in the incidence of adverse reactions between the experimental and control groups ( OR=0.64, 95%C/ [0.25, 1.63], P=0.35). Light therapy combined with sodium hyaluronate for knee osteoarthritis has greater advantages than intraarticular injection of sodium hyaluronate alone, with high efficacy and safety. However, further investigations with high-quality and large sample size randomized controlled studies are still warranted. [ABSTRACT FROM AUTHOR]

In line with the problems of water production and liquid accumulation in gas wells, the technology for foam drainage gas recovery is mainly used in Sulige Gas Field. The traditional technology for foam drainage gas recovery is manually injected from trucks, which has a lot of work and costs much, and gas wells are hard to control. For this reason, and in combination with field demand and wellhead conditions, a device has been developed which can remote control and automatically drop solid ball-like displacing agent, which increases the foaming time of the agent, improves the agent efficiency and also effectively reduces the labor intensity and labor cost. This device is powered by solar panels, so it has a low energy consumption and can satisfy the demand for chemical addition according to fixed time interval, fixed amount and fixed frequency. The ball storage barrel is designed to be at atmospheric pressure and easy to add bubbles to displace balls manually. The success test of this technique provides a new concept for digitized drainage gas recovery for Sulige Gas Field and has a broad application prospect. It is suggested to further promote the use this technique. [ABSTRACT FROM AUTHOR]

Fishing work in horizontal wells is a high difficult and high risky operation. The horizontal section has large friction resistance and difficult torque transmission, so the conventional fishing string assembly of jarring, back off, and casing milling is hard to obtain expected results. According the problem above, combined with the lithology of openhole section, some aspects are studied, such as increasing effective drilling pressure, decreasing wellbore friction resistance, revering jarring assembly, and operimizing fishing and milling tools, resulting in optimization of the conventional fishing string. The fishing operation on Well NB35-2-B29hst1 proved that the optimized fishing string increased sharply the fishing efficiency of openhole horizontal wells and decreased operation risk, which could be a reference for fishing operations on similar wells. [ABSTRACT FROM AUTHOR]

Inflammatory injury of the intestine is often accompanied by symptoms such as damage to intestinal mucosa, increased intestinal permeability, and intestinal motility dysfunction. Inflammatory factors spread throughout the body via blood circulation, and can cause multi-organ failure. Pyroptosis is a newly discovered way of programmed cell death, which is mainly characterized by the formation of plasma membrane vesicles, cell swelling until the rupture of the cell membrane, and the release of cell contents, thereby activating a drastic inflammatory response and expanding the inflammatory response cascade. Pyroptosis is widely involved in the occurrence of diseases, and the underlying mechanisms for inflammation are still a hot spot of current research. The caspase-1 mediated canonical inflammasome pathway of pyroptosis and caspase-4/5/8/11-mediated non-canonical inflammasome pathway are closely related to the occurrence and development of intestinal inflammation. Therefore, investigation of the signaling pathways and molecular mechanisms of pyroptosis in intestinal injury in sepsis, inflammatory bowel diseases, infectious enteristic, and intestinal tumor is of great significance for the prevention and treatment of intestinal inflammatory injury.

Objective: To identify the landmarks of transpterygoid approach and to report its application in a series of cases., Methods: Two silicon-injected adult cadaveric heads(4 sides) were dissected by performing an endoscopic endonasal transpterygoid approach after CT scanning for imaging guidance. High-quality pictures were obtained. This approach was used to treat twelve patients with skull base lesions including 3 spontaneous cerebrospinal fluid (CSF) leaks in the lateral recess of the sphenoid sinus, 2 neurofibromas and 2 Schwannomas involving the pterygopalatine fossa and infratemporal fossa, 1 dermoid cyst involving the middle fossa and infratemporal fossa, 1 invasive fungal sinusitis invading the middle fossa base, 1 basal cell adenoma in the upper parapharyngeal space, 1 chondrosarcoma in the parasellar region and 1 adenoid cystic carcinoma. Clinical records were reviewed., Results: In terms of approach dissection, important landmarks, such as the sphenopalatine foramen and artery, vidian canal and nerve, foramen rotundum and maxillary branch of trigeminal nerve, foramen ovale and mandibular branch of trigeminal nerve, as well as pterygoid segment of Eustachian tube were identified. In terms of clinical data, three patients with spontaneous CSF leak underwent repair. Six patients with benign lesions underwent complete tumor resection. In the patient with invasive fungal disease, thorough debridement was undertaken and antifungal drug was administered for one month. For these benign skull base lesions, there was no recurrence during the follow-up period. In the patient with chondrosarcoma, most of the tumor was removed in the first operation, and was followed by two endoscopic operations because of fast growth of the tumor. Final control was achieved with chemotherapy and radiation. In the patient with adenoid cystic carcinoma, tumor recurred five years after surgery, and was reoperated., Conclusion: An understanding of the landmarks of the transpterygoid approach is paramount for surgically dealing with disease located within and adjacent to the region of the pterygoid process of the sphenoid bone. The endoscopic endonasal transpterygoid approach is feasible and safe in selected patients with skull base lesions.

Objective: To explore the application of immediate recurrent laryngeal nerve reconstruction in the treatment of thyroid cancer invading the recurrent laryngeal nerve., Methods: Ten patients with thyroid cancer invading unilateral recurrent laryngeal nerve underwent radical surgery and immediate recurrent laryngeal nerve reconstruction. The reconstructive surgical approach included recurrent laryngeal nerve decompression surgery, end-to-end anastomosis of the recurrent laryngeal nerve, anastomosis of ansa cervicalis nerve to the recurrent laryngeal nerve, and nerve-muscle pedicle (NMP) technique. Among the ten patients, one underwent nerve decompression, one underwent end-to-end anastomosis of the recurrent laryngeal nerve, seven had anastomosis of ansa cervicalis to recurrent laryngeal nerve, and one case had anastomosis of ansa cervicalis to recurrent laryngeal nerve combined with nerve-muscle pedicle (NMP) technique. The effect of surgery was evaluated by videolaryngoscopy, maximum phonation time (MPT), phonation efficiency index (PEI) and voice assessment. T-test was used in the statistical analysis., Results: All of the 10 patients had no complications including tumor recurrence and hypoparathyroidism after the surgery. Their hoarseness symptoms were improved, and the patients returned to normal or near-normal voice. Postoperative videolaryngoscopy showed that paralyzed vocal cord returned to normal muscle tone and volume, and the vocal cord vibration and mucosal wave were symmetric and the patients got good glottal closure. The pre- and post-operative maximum phone times of the patients were (4.52 ± 0.89) s and (11.91 ± 1.87) s, respectively (P < 0.01). The pre- and post-operative phonation efficiency indices were (1.37 ± 0.43) s/L and (4.02 ± 1.33) s/L, respectively (P < 0.05)., Conclusions: In patients with thyroid cancer invading unilateral recurrent laryngeal nerve, immediate recurrent laryngeal nerve reconstruction following radical surgery of thyroid cancer can effectively achieve recovery in phonation function and improve the quality of life of the patients.

Objective: To describe a modified lateral pharyngoplasty with partial transsection of levator veli palatine muscle in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) and report the primary outcomes., Method: Retrospective review was performed in sixty patients with OSAHS. All the patients underwent modified surgical procedures, including partial transsection of levator veli palatine muscle and high soft palatoplasty., Result: The patients with a reduction of the AHI at least 50% were 6 (6/60, 10%). The patients with a reduction of the AHI at least 50% and a postoperative AHI < 20 were 44 (44/60, 73.3%). The patients with a postoperative AHI < 5 were 10 (10/60, 16.7%). Postoperative complications were postoperative bleeding in two cases (3.3%) and short-term velopharyngeal insufficiency in 10 cases (16.7%)., Conclusion: Lateral pharyngoplasty with partial transsection of levator veli palatine muscle provides a safe and effective procedure for selected OSAHS patients with oropharyngeal collapse as the main site.

Objective: To investigate the diagnosis and therapy of space-occupying lesion of middle skull base involving sphenoid sinus., Method: A retrospective analysis was performed. Eighteen patients with extradural space-occupying lesion of middle skull base involving sphenoid sinus underwent transnasal endoscopic surgery., Result: One case of primary empty sella turcica was misdiagnosed as sphenoidal sinus cyst. One case of fibrous dysplasia and one case of meningioma were all misdiagnosed as mycotic sphenoiditis. Total rate of misdiagnosis was 16.7%. Among the 18 cases, 17 cases underwent complete resection of the lesion, and only 1 case underwent major resection of the lesion. The amount of blood loss during surgery ranged between 100 ml and 2,500 ml. One case had bacterial meningitis which was cured after corresponding treatment. One case was blind in both eyes. And the other case died of pulmonary embolism., Conclusion: Transnasal endoscopic surgery is feasible and practical to treat benign space-occupying lesion of sphenoidal sinus and extradural lesion of middle skull base involving sphenoidal sinus. Definite diagnosis, accurate location and careful operation are important to complete the surgery successfully.

With the image data (SPOT), soil utilization map (1:50000) and other related materials of Harbin, and under the support of GIS, RS and GPS techniques, this paper obtained the landscape pattern of Harbin suburb and the Digital Elevation Model (DEM) of Harbin. Indices including mean patch area, landscape dominance, mean slope, mean altitude, and fragmentation degree were selected and synthetically analyzed, with the ecological landscape planning made by DEM model. The results showed that 3S techniques could help to decide typical landscape types. The landscape type database was established, and the landscape type thematic map was generated, with land use status and landscape distribution, physiognomy, and land use types combined. The ecological landscape planning was described in large scale with the image data and DEM combined, and the landscape structure of Harbin suburb was reflected directly with the ecological landscape planning and DEM combined, which improved the ecological function in this region, and provided scientific bases to the healthy development in urban-rural integration area.

Objective: To find a way of reserving normal high quality phonatory function after vocal cord surgery., Methods: Various benign lesions (vocal nodules, polyp of vocal cord, cyst of vocal cord, etc) as well as premalignant lesion and early glottic cancer were treated with minimally excision, lateral microflap, medial microflap, submucosal infusion, mucosal stripping or epithelium stripping of phonomicrosurgical techniques to achieve minimally invasion., Results: The 1,044 (99.8%) patients suffering from vocal nodules, polyp or cyst and 12 Reinke's edema achieved a normal phonation within a week. The recovery of normal phonation in 20 Reinke's edema, 31 vocal cases needed 1-3 months, by mucosal stripping. The restoration of phonation on 5 papilloma, 36 early malignancy were better than trans-cervical operation. After 5 year follow-up, 3 cases of vocal cord premalignant lesions received the re-stripping operation. 32 cases of early glottic cancer remained tumor free, 5 cases relapsed and 2 cases received the re-stripping operation, and 2 cases received laryngectomy operation., Conclusion: The phonomicrosurgery may cure vocal disease and reserves good voice function.