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To comprehensively explore the nutritional quality and construct evaluation system, this paper studied the effects of different planting ways and growing years on the 23 nutritional qualities of Tonggu Polygonatum cyrtonema Hua, and constructs of its evaluation system by correlation, factors, and clustering analysis. The results showed that the content of ethanol-soluble extractives, protein, essential amino acids (EAA), medicinal amino acids (MAA), ash and 5 constant mineral elements in Polygonatum cyrtonema Hua from greenhouse planting (GP) was the highest, and the nutritional score of EAA was also the optimal. Also, the content of polysaccharide and saponins in Polygonatum cyrtonema Hua from open planting (OP) was the most, and the four trace elements (Fe, Mn, Zn and Se) were the highest in underwood planting (UP). The Polygonatum cyrtonema Hua from wild (W) had the highest content of flavonoids and total phenols. In addition, as the extension of growing years, the content of ethanol-soluble extractives, lipid, and polysaccharides in Tonggu Polygonatum cyrtonema Hua increased gradually, while there was no significant difference in the saponins, flavonoids and total phenols (P>0.05). However, the content of starch, crude fiber, protein, ash, nutritional score of EAA and mineral elements in Polygonatum cyrtonema Hua was negatively correlated with the growing years. In particular, the decline of nutritional quality in GP was the most significant. Through the analysis of correlation, factor, and cluster, the 22 indicators of nutritional quality were simplified into 13 indicators, and then a comprehensive evaluation model was established by principal component analysis (PCA). It was found that the comprehensive score (−1.331~1.161) of nutritional quality of 8 types was GP-3>UP-3>W-4>GP-5>GP-4>OP-3>UP-4>OP-4, that is, the nutritional quality of GP-3 was optimal. And on this basis, a 6-level standard for the nutritional quality comprehensive evaluation of Polygonatum cyrtonema Hua was established. These results will provide a theoretical basis for the screening of raw materials for development of high-value products and variety improvement of Polygonatum cyrtonema Hua.

There are frequent cataclastic rockfall disasters in southwest mountainous areas. To accurately simulate the process of rockfall movement and quantify the risk of rockfall, it must first determine the volume of rockfall. However, to date, there is no effective and reliable method to estimate the volume of rockfall. This study constructed an effective method of estimating cataclastic rock rockfall volume based on image recognition. The application and verification of this method was conducted at the rockfall of Yaohe Dam in Shimian of Yaxi Expressway in 2020. Through in-site measurement and close photogrammetry of UAV, the partition and sampling area of rockfall accumulation area are determined. Using the open-source software of image processing (ImagePy), a quick block identification step is established, and characteristic parameters, such as equivalent particle size, perimeter, and area of blocks, are extracted. The method of estimating the volume of cataclastic rock rockfall based on the volume distribution of blocks was applied and verified by rock rockfall in the field. The results show that: (1) ImagePy software has high speed and accuracy in block image recognition; (2) The obtained distribution curve of rock volume is nearly consistent with that measured in the field; (3) The estimated volume of rock rockfall in Yaohe Dam accounts for nearly 80% of the volume obtained by three-dimensional point-cloud difference method. Thus, it is feasible to use image recognition technology to extract the particle size and estimate the size of cataclastic rock mass, and it has the advantages of high efficiency and accuracy. This method can be applied to rapid assessment of cataclastic rock mass and quantitative risk assessment. Statistical block volume distribution can provide data support for fragmentation research.

Objective The impact and fracture of rockfall are important reasons for the difficulty in predicting movement trajectories, and the geometric characteristics of slope bodies are key factors affecting the movement. Methods To study the crushing process of rockfalls and the influence of slope geometry characteristics on the movement of rockfall blocks, discrete element method (PFC2D) simulation technology was used to establish a rockfall free-fall-impact model to analysethe rock mass structure and slope geometry characteristics of typical rockfall disaster points. The fragmentation process of rockfall under different fall heights and impact angles is analysed, and the block motion velocity, crack number and impact force are obtained. Moreover, the two-parameter Weibull distribution is used to describe the fragmentation degree of blocks. Results The experimental results reveal that the fracture process can be divided into three stages: Contact-disintegration, extrusion-fragmentation and independent movement. Rock mass fragmentation starts at the impact point, disintegration occurs along the structural plane first, and fragmentation occurs on the new fracture plane. Sudden changes of the block velocity, crack quantity and impact force occur in the contact-disintegration and compression-fragmentation stages. The block velocity plummets, exhibiting a "step effect", and the impact force rises sharply, revealing a "double peak phenomenon". Moreover, when the fall height increases or the impact angle decreases, the "step effect" and "double peak phenomenon" become more obvious. Under the same impact angle, an increase of the fall height results in the increase of impact kinetic energy, thus increasing the degree of fragmentation and decreasing the particle size distribution range and characteristic particle size. At the same fall height, an increase in the impact angle causes that the contact area is reduced, and the degree of breakage is reduced, increasing the particle size distribution range and characteristic particle size. Conclusion The present results provide technical support for revealing the impact fragmentation mechanism of rockfall slopes and predicting the trajectory of block motion.

V-Raf murine sarcoma viral oncogene homolog B (BRAF) alteration is one of the most essential driver genes of non-small cell lung cancer (NSCLC). BRAF encodes serine/threonine protein kinases, and its mutations typically lead to protein compositional activation, thereby activating the mitogen-activated protein kinase kinase (MEK) signaling pathway. A promising new approach for the treatment of mutated BRAF and/or downstream MEK may provide customized treatment opportunities for BRAF driven NSCLC patients. However, combination therapy is necessary to overcome the difficulties such as short duration of benefit, poor therapeutic effect of non-V600 BRAF mutations and susceptibility to drug resistance. This article reviewed the progress in structural characteristics, related signaling pathways, mutation types of BRAF gene, and the clinical pathological relationship between BRAF mutations and NSCLC, as well as the therapy, in order to provide more evidences for clinical doctors to make treatment decisions.

ObjectiveTo investigate the prevalence of chronic kidney disease (CKD) and the association of obesity with CKD among hypertension patients registered at community health service centers in suburb of Shanghai. MethodsThe participants of the study were 3 600 hypertensive patients randomly recruited from chronic disease patients registered at two community health service centers in a suburban district of Shanghai city. Face-to-face interview with a self-designed questionnaire and the International Physical Activity Questionnaire, physical examination, laboratory tests were conducted among the participants during October – December 2021. Unconditional multivariate logistics regression model was adopted to analyze the association between body mass index [BMI] and CKD. ResultsOf the 2 991 participants finally included in the analysis, 1 037 (34.67%) were identified as having CKD and the number (proportion) of the participants with decreased estimated glomerular filtration (eGFR), proteinuria, and hematuria were 464 (15.51%), 677 (22.63%), and 99 (3.31%), respectively. After adjusting for age, sex, education, smoking, alcohol drinking, physical activity, diabetes, blood lipids and blood pressure control, unconditional multivariate logistic regression analysis revealed that the participants with obesity (BMI ≥ 28.0) were at a significantly increased risk of having CKD (odds ratio [OR] = 1.498，95% confidence interval [95%CI]: 1.203 – 1.866), decreased estimated glomerular filtration (OR = 1.340，95%CI: 1.001 – 1.793), and proteinuria (OR = 1.388，95%CI: 1.088 – 1.771) compared to those with normal or low body weight (≤ 23.9). Conclusion The prevalence of CKD was high and positively correlated with obesity among hypertension patients registered at community health service centers in suburb of Shanghai.

The Redamen rare metal deposit is located in the south western part of Keeryin pegmetite typed ore field in western Sichuan. It is a special deposit in the aspects of surrounding rock, element mineralization zoning and distance. The ore with different elevation (3540~3830 m) of the same vein and the same orebody is systematically collected, spodumene single mineral is selected to analyze the C-H-O isotope composition and features of inclusions in different minerals.The inclusions in minerals are mainly liquid-rich inclusions. The salinity of the inclusions in spodumene is 8%~20%, and the homogenization temperature is 180~330℃. The inclusions belong to the ore-forming fluid with medium-low salinity and medium-high temperature. The inclusions in quartz have salinity of 0%~8%, homogenization temperature of 150~240℃, and belong to low salinity and low temperature fluid. The results of C-H-O isotope test show that the δD/‰ of spotamene in the Redamen rare metal deposit ranges from -97.5 to -104.7 (average of -102.8). Compared with the Lijiagou deposit in the southeast of the ore field, the δD/‰ of spodumene is obviously smaller, with the δ18OH2O/‰ ranging from -0.34 to 2.88 (average of 1.032). However, it is basically consistent with the main metallogenic period of spodumene in Lijiagou deposit, indicating that the ore-forming fluid of late mineralization (that is, the main metallogenic period of spodumene) is mixed with meteoric water. The δ13CV-PDB/‰ of spodumene in the Redamen rare metal deposit ranges from -10 to -16.6, with an average of -12.7, indicating that the carbon source in the main mineralization period (spodumene formation period) has a mixed nature of magmatic system and meteoric precipitation system, which is related to the low temperature alteration of magmatic mantle source (granite, mantle multi-phase system) and may be mixed with CO2 generated by the decarboxylation of deposited organic materials. Through the study of mineral C-H-O isotopes and fluid inclusions, the source and evolution process of ore-forming fluids were further clarified.

Post-fire debris flow is a special torrent containing a large amount of loose material, which is closely related to forest fire. Its characteristics are significantly different from the conventional debris flow. Therefore, conventional debris flow prevention experience is not completely applicable to it. After the fire that broke out on March 30 in Xichang, debris flow occurred frequently in burned area, seriously threatening the safety of local people's lives and property. It is necessary and urgent to study the characteristics of debris flow after fire and put forward comprehensive prevention and control measures. This study takes Dianchichang gully in Xichang, Liangshan Yi Autonomous Prefecture, Sichuan Province as a typical case. Analyzed the characteristics of burned area and watershed. Studied the characteristics of post-fire debris flow disaster. And proposed the corresponding prevention and control measures. The results show that the burned area covered 83.37%, seriously burned areas accounted for 33.47%, resulting in widely spread ash layer. Slope provenance accounted for 69.83%. Post-fire debris flow occurred one month after the forest fire, and a total of 5 debris flows occurred in the first rainy season. Moreover, the threshold of debris flow starting rainfall is small and the occurrence of debris flow increases rapidly. The post-fire debris flows in the study site are characterized by high frequency and sudden occurrence. Accordingly, the corresponding prevention and control measures were propound as follows. The rapid emergency treatment measures include clarifying dead wood on slope surface, vegetation restoration, and building of simple barrier dams in gully. Medium-term governance measures are debris dams in gully and grit basins. And long-term prevention measures are a combination of forest fire prevention and vegetation protection. This scheme has been implemented in Dianchichang gully. Since the completion of these projects, the effects of comprehensive treatments have been preliminarily proved effective for the mitigation of this type of special debris flow. It can provide reference for post-fire debris flow prevention in the future.

Sulfur (S2-) is closely related to the migration and enrichment of arsenic (As) in the water environment, but its mechanism of action in different aqueous medium is still unclear. To determine the adsorption characteristics of As by river sand, a common aqueous medium in the hyporheic zone, under the action of S2-, the adsorption kinetics experiment of As on river sand and the adsorption experiment of As by river sand under the action of S2- are designed and carried out. Combined with simulation calculation by PHREEQC and characterization tests based on XRD, SEM-EDS, XPS and FTIR, the mechanism of action is further identified. The results show that the adsorption of As by river sand reaches adsorption equilibrium at approximately 200 h and the adsorption capacity of As(Ⅴ) is significantly higher than that of As(Ⅲ) at the solid-to-liquid ratio of 25 g/L; with increasing S2- concentration, the adsorption capacity of river sand to As decreases gradually. The simulation and characterization test results show that a small amount of As is adsorbed on the surface of river sandandis mainly combined with Fe and Al on its surface. The adsorption of As (Ⅲ) may also be related to SiS2 that is formed after the fracture of the Si-O bondwith S2-. The main influence mechanism of S2- on the adsorption of As by river sand is as follows: ① the addition of S2- increases the pH of the solution and decreases Eh, thus inhibiting the adsorption of As; ②under the condition of adding S2-, Fe and Al on the surface of river sand can form compounds such as AlAs, AlAsO4, FeS2 and Fe4As2O11 with S and As, which reduces the active sites of As adsorption on the surface of river sand.

【Objective】With the implementation of "plastic ban" in Hainan Province, the traditional plastic bandage of rubber tree bud grafting can no longer be used, and it is urgent to use degradable materials as bandage in the process of rubber tree bud grafting.【Method】With Badi degradable bandage grafted by different workers as budding bandage, the effects of traditional plastic bandage and Badi degradable bandage on the survival rate, sprouting rate and growth potential of mini-seedling buddings and young seedling buddings of rubber tree were compared.【Result】The survival rate of mini-seedling buddings with traditional bandage was 47.33%-70.70% and the sprouting rate was 90.00%-99.53%, while the survival rate of buddings with Badi degradable film was 35.32%-57.00% and the sprouting rate was 86.18%-92.56%, indicating that the survival rate and sprouting rate of buddings with the traditional bandage were significantly higher than those with Badi bandage. In the first leaf whorl, the leaf whorl distance with the traditional bandage (19.24 cm) was significantly higher than that with the Badi degradable film (18.06 cm), and there was no significant difference in other growth indexes. In the second leaf whorl, the stem diameter of traditional bandage (4.62 mm) was significantly higher than that of Badi degradable film (4.06 mm), while the whorl distance of Badi degradable film (11.27 cm) was significantly higher than that of traditional bandage (9.88 cm), but there was no significant difference in the growth indexes of other scions. Among the young seedling buddings, the survival rate of traditional bandage treatment was 92.70%-98.09% and the sprouting rate was 93.64%-99.75%, while the survival rate of Badi degradable film treatment was 73.33%-86.67% and the sprouting rate was 92.50%-96.85%, indicating that the budding survival rate of the traditional bandage treatment was significantly higher than Badi bandage treatment, and the sprouting rates were above 90%, there was no significant difference in the growth indexes of scions.【Conclusion】The budding survival rates of mini-seedlings and young seedlings were significantly reduced by the Badi degradable film, and the sprouting rate of mini-seedlings and the growth potential of scions were significantly affected, but the growth potential of young seedling budding was not significantly affected. The bud grafting skill of the graft worker was also one of the key factors affecting the budding survival rate. Therefore, Badi degradable film could not be widely used in the mini-seedling buddings, but could be properly used in the young seedling budding of rubber tree.

On March 30, 2020, a forest fire broke out in Jingjiu Township, Xichang City, and the vegetation in Xiangshui gully watershed was burned in a large area by forest fire. In the rainy season of the same year, debris flow broke out in many gullies in the Xiangshui gully watershed, of which 1#, 2#, 3# gullies were adjacent to residential houses and cultivated land, and the impact of the debris flow was relatively serious. Through field investigation, remote sensing interpretation, and outdoor test, taking Xiangshui gully 1#, 2#, 3# gully as the research object, the differences of permeability characteristics, slope erosion, and gully erosion under different forest fire intensities are analyzed, so as to reveal the disaster mechanism of post-fire debris flow of Xiangshui gully. The results show that forest fire is an important inducement for the outbreak of debris flow, and the rainfall threshold of debris flow after the fire will be significantly reduced. Forest fire disturbance leads to the decrease of the permeability coefficient of slope soil in varying degrees. The more serious the forest fire intensity is, the smaller the permeability coefficient is, and the rainfall is transformed into slope runoff in a larger proportion to participate in slope erosion. With the increase of rainfall times, the depth of slope soil erosion in light, moderate and severe fire areas increased. The difference of erosion depth between moderate and severe forest fire intensity is small, and it is significantly higher than that in light areas, indicating that when the forest fire intensity reaches moderate, the slope soil will be eroded to a greater extent. For the gully with similar topographic conditions, the more serious the forest fire intensity is, the stronger the erosion capacity of debris flow is, which is finally reflected in the greater the number of landslide bodies on both sides of the gully and the greater the width and depth of the gully.

The traditional high-level remote landslide recognition efficiency which relies on the artificial discrimination of geological experts is low. In this paper, an automatic landslide terrain recognition model based on deep learning is developed to improve the efficiency of the screening of potential landslide hazard in a large area. The model takes remote sensing images, DEM data, geological zones, river system and other geological observation data of the target area as input. For the huge difference of different types of observation data, a feature branch network is designed and constructed to accurately extract the corresponding landslide features: Among them, deep network architecture is used to extract complex features from optical image data, and shallow network architecture is used to extract features from structured data such as altitude, geological composition, river and fault zone distribution. Subsequently, a feature fusion module was designed to fuse the extraction results of the two networks to obtain a comprehensive landslide hazard feature. The model performs semantic segmentation of the landslide area based on the extracted landslide features, and achieves accurate pixel-level landslide terrain classification and positioning. The experimental results show that the recognition accuracy(ACC) of the model reaches 0.85, which can provide technical support for automatic landslide identification.

The riparian zone is a typical groundwater-surface water interaction zone, and there are few research reports on the behavior of arsenic in this interaction zone under different hydrodynamic conditions. In this study, the river sand samples from the riparian zone are collected to carry out indoor column experiments, the influence of different hydrodynamic factors (including flow velocity and particle size) on the migration of arsenic in the river sand are analyzed, and related models are established. The results show that (1) at a flow rate of 0.5 mL/min, the adsorption rate of the river sand on As(V) and the time required to reach an equilibrium state are both faster than those on As(III), and the smaller the particle size, the more obvious the phenomenon; at a flow rate of 1.0 mL/min, the adsorption rate of the river sand with different particle sizes on As(V) increases with the increasinng particle size, but there is no significant difference in the adsorption of As(III). (2) In a packed column filled with sand of the same particle size, the adsorption capacity of the river sand for As(III) and As(V) decreases with the increasing flow velocity. (3) Under the conditions of different flow rates and particle sizes, the migration processes of As(III) and As(V) in the sand column are more in line with the Thomas model, and the fitting R2 are higher than those of the Yoon-Nelson and Adams-Bohart models under the same conditions. Among them, at low flow rates, the Thomas model fitting R2 (≥0.94) to the migration processes of As(III) and As(V) in the particle size of 0.15−0.25 mm are significantly better than that of the larger particle size of 1.00−2.00 mm. At high flow rates, the model has little difference in fitting R2 to the migration process of arsenic in different particle sizes.

Bauxite-type vanadium deposit in north sichuan is a newly discovered type of vanadium deposit. Through the study of process mineralogy and selectivity of vanadium, it is found that vanadium has two kinds of occurrence states: The main is an independent mineral in the form of vanadite, and the other is in the form of isomorphism in sericite and illite. The experimental study on the washability of vanadium ore shows that the bauxite type vanadium ore is economic. The valuable element vanadium and molybdenum in ore can be recovered effectively by the combined flowsheet of “ Recovery of sulfide by heavy separation- recovery of vanadium and molybdenum from tailings by roasting in air and alkaline leaching-Recovery of clay ore by leaching residue”. The associated pyrite and clay minerals in ore are utilized synthetically. After the test, the slag leaching rate of vanadium is 74.42%, the liquid leaching rate of vanadium is 75.97%, the slag leaching rate of molybdenum is 88.77%, the liquid leaching rate of molybdenum is 91.00%.

Landslide dams formed by unstable slope usually blocks the river, and later fail to trigger huge floods threatening the downstream residents' lives and properties.In order to improve the ability of active disaster reduction and prevention, it is urgent to construct a method to quickly predict and judge the ability of landslide to build dams.This paper firstly extracts the geomorphic characteristic parameters of 70 typical landslides based on literature reading and remote sensing, including 50 damming landslides.The five parameters (landslide volume, area, relief, length and river width) are determined by K-S test and M-W U test, and the Boruta algorithm is used to determine the factor importance.Then, the Bayes discriminance method and logistic regression method are used to build a prediction model of the landslide dam, in which the accuracy exceeds 90%.The threshold equation combined with H and L/Wr is determined by using factors with high importance and significant differences and the ratio method in order to carry out a rapid judgment of landslide dams formation.The statistic analysis of the landslide geomorphic characteristics of different triggering factors and the prediction result of V-Wr empirical formula determine the relationship between landslide dams formation and triggering factors, providing technical support for the further construction of prediction models for the formation of landslide dams with different inducements.

On May 7, 2020, a forest fire broke out in Zhongba Village, Luji Township, Xide County, Liangshan Yi Autonomous Prefecture, Sichuan Province, covering an area of about 6.7 km2. After the forest fire, the ash on the slope was about 2～6 cm thick, and the surface soil structure was disturbed. Under the heavy rainfall of about 20 min in the evening of June 4, the post-fire debris flow disaster broke out in the four gullies at the back mountain of Zhongba Village, which is a great threat to the 164 residents of 41 households in the gully mouth. Through remote sensing interpretation and field investigation, the fire intensity and deposit distribution characteristics of four gullies in the burned area are identified, the development characteristics of post-fire debris flow in Zhongba Village, Xide County are analyzed, and the risk assessment is carried out. Based on the real-time rainfall data obtained from group survey and group prevention, a set of early-warning and risk avoidance scheme for debris flow in mountain areas after fire is proposed, which has been verified by this example.

GWHP system is easy to cause the thermal breakthrough which will reduce the operation efficiency, when the site area is small. In the design of GWHP, by setting up a thermal barrier well between the pumping and recharging well can reduce the heat transfer speed between pumping and recharging well, which is conducive to prolonging the occurrence time of thermal breakthrough. 36 groups of GWHP operation scenarios under the cooling condition are simulated through heat transfer model, and the influence of the location, structure and recharge quantity of the thermal barrier well on the thermal breakthrough and the aquifer’s temperature field are analyzed. The results show that the increase of recharge quantity of the thermal barrier well is conducive to improving the thermal barrier effect, but the degree of improvement decreases with the increase of recharge quantity. At the same time, with the increase of recharge quantity, the maximum drawdown will increase linearly. The location of the thermal barrier well has little influence on the aquifer temperature field and the closer the barrier well is to the recharging well, the later the thermal breakthrough time will be. Increasing the length of the filter tube in the heat barrier well can improve the thermal barrier effect, and the effect of the thermal barrier is gradually enhanced with the increase of the recharge quantity. In addition, through the long-time simulation of model, it is found that the operation of the heat barrier well can concentrate the energy near the recharging well. When the GWHP adopts the exchange operation mode of pumping and recharging well, it can make full use of the aquifer energy storage and improve the operation efficiency of heat pump.

Traditional clinical nutrition research mostly stay at the stage of human and animal experiments. Cell model experiment has gradually become an important way in clinical nutrition research nowadays. Firstly, this review mainly summarizes the cells commonly used in nutrition research and gives a general introduction of diseases in clinical nutrition using cell models such as atherosclerotic cardio-cerebrovascular disease, sarcopenia, kidney diseases, tumor, gastrointestinal diseases, liver damage, allergic inflammation, burns and so on. Then it focuses mainly on the diseases which are the leading death causes of the Chinese residents, reviewing the use of cell models the advantages as well as their scientific significance and the development and application trend of cell model (3D cell, cytome, microfluidic, high throughput and high content). Finally, the limitations of cell model experiments in clinical nutrition are summarized, and new technologies used in cell model experiments of clinical nutrition are prospected.

Background and objective Surgical procedure is the main method of treating lung cancer. Meanwhile, postoperative pneumonia (POP) is the major cause of perioperative mortality in lung cancer surgery. The preoperative pathogenic airway bacterial colonization is an independent risk factor causing postoperative pulmonary complications (PPC). This cross-sectional study aimed to explore the relationship between preoperative pathogenic airway bacterial colonization and POP in lung cancer and to identify the high-risk factors of preoperative pathogenic airway bacterial colonization. Methods A total of 125 patients with non-small cell lung cancer (NSCLC) underwent thoracic surgery in six hospitals of Chengdu between May 2015 and January 2016. Preoperative pathogenic airway bacterial colonization was detected in all patients via fiber bronchoscopy. Patients’ PPC, high-risk factors, clinical characteristics, and the serum surfactant protein D (SP-D) level were also analyzed. Results The incidence of preoperative pathogenic airway bacterial colonization among NSCLC patients was 15.2% (19/125). Up to 22 strains were identified in the colonization positive group, with Gram-negative bacteria being dominant (86.36%, 19/22). High-risk factors of pathogenic airway bacterial colonization were age (≥75 yr) and smoking index (≥400 cigarettes/year). PPC incidence was significantly higher in the colonization-positive group (42.11%, 8/19) than that in the colonization-negative group (16.04%, 17/106)(P=0.021). POP incidence was significantly higher in the colonization-positive group (26.32%, 5/19) than that in the colonization-negative group (6.60%, 7/106)(P=0.019). The serum SP-D level of patients in the colonization-positive group was remarkably higher than that in the colonization-negative group [(31.25±6.09) vs (28.17±5.23)](P=0.023). The incidence of preoperative pathogenic airway bacterial colonization among NSCLC patients with POP was 41.67% (5/12). This value was 3.4 times higher than that among the patients without POP (OR=3.363, 95%CI: 1.467-7.711). Conclusion An intimate correlation was observed between POP and pathogenic airway bacterial colonization in lung cancer. The high-risk factors of pathogenic airway bacterial colonization were age and smoking index.

Background and objective There are incresing lung cancer patients detected and diagnosed at the intermediate stage when the pre-malignant or early lesions are amenable to resection and cure, owing to the progress of medical technology, the renewal of detection methods, the popularity of medical screening and the improvement of social health consciousness. The aim of this study is to investigate the risk factors of the occurrence of postoperative cardio-pulmonary complications in stage I non-small cell lung cancer (NSCLC) patients, based on routine laboratory tests, basic characteristics, and intraoperative variables in hospital. Methods The 421 patients after lobectomy in patients with stage I NSCLC at the West China Hospital of Sichuan University from January 2012 to December 2013 were included into the study and stratified into complication group and non-complication group, according to whether to occur postoperative cardio-pulmonary complications after lobectomy in 30 days. Results Of them, 64 (15.2%) patients were finally identified and selected into the complication group, compared with 357 (84.8%) in non-complication group: pneumonia (8.8%, 37/421) was the primary complication, and other main complications included atelectasis (5.9%, 25/421), pleural effusion (≥middle) (5.0%, 21/421), persistent air leak (3.6%, 15/421); The operation time (P=0.007), amount of blood loss (P=0.034), preoperative chronic obstructive pulmonary disease (COPD) (P=0.027), white blood cell (WBC) count (P

Background and objective Diagnostic modes may play an important role in treatments, but minimal information is available regarding their relationship in patients with lung cancer. This study may contribute to decision making in clinics and public health centers. Methods The records of 505 hospitalized surgical patients with lung cancer at the Department of Thoracic Surgery, West China Hospital of Sichuan University from January 2013 to December 2013 were retrospectively reviewed. The patients were categorized into physical examination group (PEG, 131 patients) and symptomatic group (SG, 374 patients). Surgical approach, pathological stage, and diagnostic mode were analyzed. Results Low-dose computed tomography (46.6%, 61/131) and computed radiography (51.1%, 67/131) were used as key diagnosis methods in 131 patients in PEG. The percentage of hospitalized surgical patients with lung cancer detected via physical examination in the city (35.4%, 80/229) was also significantly higher than in the township (18.1%, 50/276) (P

An wireless catching and transferring system of next generation network was introduced. With the advanced technology of IPv6, IEEE 802.11n and cloud computing, the system provided an effective solution, meeting the needs of professional journalists to catch and transfer quickly at large games and meetings.

Background and objective The growth of tumor often faced up with lackness of blood and oxygen, and it has been reported that Annexin A1 may be involved in tumor. The aim of this investigation is to explore the characteristics of expression of Annexin A1 in lung adenocarcinoma A549 cells after hypoxia. Methods A549 cells were exposured to either normoxia (21%O2) or hypoxia (1%O2) condition for 4 h, 12 h, 24 h. The expressions of Annexin A1 mRNA levels were measured by RT-PCR. The expressions of Annexin 1 protein were investigaged by Western blot. The relative content of reactive oxygen species (ROS) were assayed by special kit. The expressions of nuclear translocation of NF-κB was assayed by Western blot; After been treated with ROS scavenger NAC and PDTC, the levels of Annexin 1 protein of A549 cells were measured by Western blot. Results Compared with normoxia group, the Annexin A1 mRNA in hypoxia group increased after 4 h, and then decreased gradually; Moreover, Annexin 1 protein levels of A549 cells were also increased when treated with hypoxia. An increaing of ROS production in cells exprosed to hypoxia was detected. NAC and PDTC inhibited hypoxia-induced Annexin A1 increase. Conclusion Hypoxia upregulates the expression of Annexin A1 in lung adenocarcinoma A549 cells, in which process ROS-NF-κB may paticipate in.

With the advent of the Internet of things and the era of Cyber Physical System,more data can be collected and analyzed,and industrial big data have become important driving force for industry innovation and transformation.Unlike traditional Internet big data,industrial big data are closely integrated with industrial logic.The difference between industrial big data and internet big data was compared in detail.Combined with the classical cases,the process of demand driven transformation of traditional manufacturing industry and the development path of industrial big data were expounded.The structure and working principles of industrial big data platform were introduced.At last,taking the excavator business as an example,it shows the application effect of the industrial big data platform,and that having a share in data and models will make data based application produce more value was put forward.

The goal of distributed consensus is quite simple i.e.how to decide a value among a group of coordinated processes in the distributed environment.However,the problem is turned out to be very difficult while facing the different distributed environment.The even harder problem is that some consensus protocols are hard to be implemented in practical systems.Some results of distributed consensus algorithms under different distributed environment assumptions were reviewed.In addition,some practical systems based on consensus for achieving high reliability were discussed.

Background The gradual increase in blood lipid levels is becoming a significant public health concern. The role of diet in the development of dyslipidemia is crucial. Traditional nutritional epidemiology mainly focuses on individual foods or food groups. However, in our daily lives, we do not only consume isolated nutrients or specific foods, which makes it challenging to determine the specific impact of individual dietary components on dyslipidemia. Currently, there is a lack of research both domestically and internationally that investigates the relationship between dietary patterns and dyslipidemia in the population of Southern Jiangxi (Gannan) . Objective To analyze the relationship between dietary patterns and dyslipidemia in Southern Jiangxi, with the aim of contributing to evidence-based nutritional policies. Methods Data from the Gannan chronic disease cohort 2020 survey data. A multi-stage stratified cluster random sampling method was used to select research participants among permanent residents aged 35 and above in Southern Jiangxi from July to August 2020. Demographic data were collected through standardized questionnaires and physical examinations. Fasting blood glucose and lipid levels were measured. Dietary surveys utilized a food frequency questionnaire, and patterns were identified through factor analysis. The patterns were categorized into quartiles (Q1-Q4) based on factor scores. Logistic regression was used to assess the impact of patterns on dyslipidemia. Results The study included 1 508 residents, with a prevalence of dyslipidemia of 36.07% (544/1 508). Residents who consumed adequate amounts of water, did not have a history of hypertension, and had a history of diabetes showed a higher prevalence of dyslipidemia (P

Methotrexate (MTX) is a therapeutic drug that is widely used in clinic for treatment of a variety of cancers. However, MTX has limited selectivity and serious cytotoxicity, at the same time, there are problems such as narrow therapeutic window and large individual variability in metabolism and excretion of MTX. Therefore, blood concentration monitoring is required for MTX administration in clinical practice. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has the advantages of strong specificity, good separation characteristics, high sensitivity and fast detection speed, which has become the internationally recognized “gold standard” for blood concentration monitoring of drugs. In this study, an isotope dilution mass spectrometry method was developed for accurate measurement of MTX in serum by the house-made QLIT-6610MD quadrupole-linear ion trap liquid chromatography-mass spectrometer. Unlike the traditional triple quadrupole QqQ tandem mass spectrometer, the quadrupole-linear ion trap (Q-LIT) mass spectrometer adopts the quadrupole-linear ion trap direct axial coupling design, i.e., a single linear ion trap is used to replace the QqQ tandem mass spectrometer’s back-end fragmentation cell and the quadrupole, and no other components are installed between the quadrupole and linear ion trap, which greatly streamlines the quality and efficiency of the mass spectrometer while ensuring the original performance of the instrument. With this unique configuration, the QLIT-6610MD instrument uses a simultaneous fragmentation and accumulation technique, which remarkedly reduces matrix-induced interferences and effectively reduces space charge effects. Serum samples were pretreated with methanol to precipitate proteins and the supernatants were measured by QLIT-6610MD spectrometer. The linear correlation coefficient (R2＞0.999 0) is obtained for MTX in the range of 10-5 000 μg/L. The limit of quantification is 10 μg/L. The precision of the quality control is better than 6.94%, and the recoveries of spiked serum samples are 86.39%-97.84% with a coefficient of variation less than 8.04%. We used the QLIT-6610MD and AB QTRAP 6500+ liquid chromatography-mass spectrometers to analyze 70 clinical serum samples for comparison of the performance of the house-made instrument by means of Pearson’s coefficient and BLand-ALtman method. The results showed that the QLIT-6610MD mass spectrometry achieves a similar level of performance to AB ATRAP 6500+ instrument, and provides a new domestic instrument option for clinical mass spectrometry. In addition, this study explores the possibility applying the multi-stage fragmentation technique (MSn) to determine MTX in serum, gaining fundamental data for future studies.

再酯化甘油三酯（rTG）型鱼油是甘油三酯(TG)、甘油二酯(DG)、甘油一酯(MG)和乙酯(EE)的混合物。为了解rTG型鱼油不同结构酯的组成及其对产品稳定性的影响，采用高效液相色谱-示差折光检测器检测了来自国内外10个厂家的18个批次rTG型鱼油中不同结构油脂的含量，与天然TG型鱼油和EE型鱼油进行比较，并考察了TG含量对rTG型鱼油产品稳定性的影响。结果表明：rTG型鱼油中TG含量在52.17%~94.80%，其中只有4个批次样品高于90%，偏甘酯含量在4.96%~38.97%，EE含量在0.28%~13.10%，其中有7个批次样品EE含量超过了5%，不符合欧洲药典（EP10.3）要求；天然TG型鱼油的TG含量在97%以上，EE型鱼油的EE含量在99%以上；与TG含量低( 64.09%）的rTG型鱼油产品相比，TG含量高（90.80%）的rTG型鱼油产品酸值和过氧化值相对原料变化较小；加速氧化过程中，TG含量高的rTG型鱼油产品的酸值稳定,但TG含量低的rTG型鱼油产品酸值明显增高。rTG型鱼油产品的稳定性可能与TG含量有关，TG含量高的rTG型鱼油的稳定性比TG含量低的更好。Abstract：Re-esterified triglyceride (rTG) type fish oil is a mixture of triglycerides (TG), diglycerides (DG), monoglycerides (MG) and ethyl esters (EE). In order to learn about the distribution of different structural esters in rTG type fish oil and their effects on product stability, 18 batches of rTG type fish oil from 10 factories in domestic and abroad were collected, the contents of different structure esters were determined by HPLC-differential refractive index detector and compared to nature TG type fish oil and EE type fish oil, and effect of TG content on the stability of fish oil product was investigated. The results showed that the TG content in rTG type fish oil was 52.17%-94.80%, among which only 4 batches samples were higher than 90%. The content of partial glycerides ranged from 4.96% to 38.97%, and the EE content ranged from 028% to 13.10%, with 7 batches samples exceeding 5%, which did not meet the requirements of European Pharmacopoeia(EP10.3). The TG content in natural TG type fish oil was above 97%, and the EE content in EE type fish oil was above 99%. Compared with rTG type fish oil products with low TG content (64.09%), rTG type fish oil products with high TG content (90.80%) had relatively small changes in acid value and peroxide value compared to raw materials. During the accelerated oxidation process, the acid value of rTG type fish oil products with high TG content was stable, while the acid value of rTG type fish oil products with low TG content significantly increased. TG content may be related to the stability of rTG type fish oil, and rTG type fish oil with high TG content has better stability than rTG type fish oil with low TG content.

Objective: The purpose of this study was to explore the impact of dry heating time on the Maillard reaction between rice bran polysaccharide (RBP) and whey protein isolate (WPI) in order to develop a new emulsifier for the preparation of nanoemulsions encapsulating lipid-soluble substances. Methods: The changes in absorbance at 294 nm (A294 nm), browning degree, color and free amino acid content were monitored during the Maillard reaction under dry heating condition, and the molecular mass, particle size, emulsifying activity and emulsion stability, and microstructure of the reaction product were characterized. Meanwhile, the Maillard reaction product was used to prepare soybean oil nanoemulsion. Results: As indicated by the changes in A294 nm, browning degree, color difference and free amino acid content, the Maillard reaction took place, and the color of the product became darker with an increase in reaction time. The molecular mass of the reaction product was 17 kDa, and a uniform particle size distribution was observed at 12 h of reaction. The Maillard reaction significantly improved the emulsifying activity and emulsion stability of WPI (P < 0.05). Nanoemulsion containing WPI-RBP complex at 12 h of reaction was more stable than the one containing WPI and showed uniform particle size distribution, and it could resist the negative impact of acid and salt ions. Conclusion: The Maillard reaction between WPI and RBP effectively improve the emulsifying properties of WPI, and the reaction product can be used as a new emulsifier in the food field.

Food-derived protein hydrolysates/peptides and saccharides are valuable and exploitable food resources. Covalent complexes formed by the Maillard reaction of food-derived protein hydrolysates/peptides and saccharides are superior in their structure and nutritional functions. Therefore, the Maillard reaction has been widely used to improve the functional characteristics of protein hydrolysates, and has currently become a hot spot in the field of food research. This article reviews the sources of raw materials for and the mechanism of the Maillard reaction between food-derived protein hydrolysates/peptides and saccharides and the preparation methods, structural characteristics, functional properties, nutritional and biological activities of the Maillard reaction products as well as their current applications and future prospects in the fields of food and medicine. This review provides a new idea for the development of functional food products based on the Maillard reaction between food-derived protein hydrolysates/peptides and saccharides, and provides a theoretical basis to explore their health effects in the future.

Traffic flow prediction plays a key role in intelligent transportation system.However,due to its complex spatial-temporal dependence and its uncertainty,research becomes extremely challenging.Some existing methods mainly use a single time series and input it into a recurrent neural network to capture temporal dependency.Moreover,most models only simply stack temporal modules and spatial modules,resulting in ineffective feature fusion.To address these issues,this paper proposes a multi-time scale spatial-temporal graph neural network model.The model divides the sequence data into three time-scale sequences,then puts sequence data into the ST-Blocks to extract the spatial-temporal features of data,and finally makes the prediction.In ST-Block,graph convolutional network and variant Transformer are used to capture spatial dependency and temporal dependency respectively,and the output feature of the two sub-modules are fused through a gate mechanism.A large number of experiments are conducted on two real data sets in this paper,including short-term and long-term prediction,and the results show the excellent performance of MTSTGNN model on the task of traffic flow prediction.

In this study, the chemical profiling of Jingyin Granules and the tissue distribution of nine major constituents in this Chinese medicine were performed after oral administration of Jingyin Granules to rats, by using UHPLC-Q-Exactive Orbitrap HR-MS. An Acquity UPLC BEH C&#95;(18) chromatographic column(2.1 mm×100 mm, 1.7 μm) was used as solid phase, while the mobile phase was methanol and 0.1% formic acid water for gradient elution. The major constituents in this Chinese medicine were quickly and accurately identified, via comparison with the retention times and MS/MS spectra of the standards. A total of 106 chemicals were identified from Jingyin Granules, including 24 kinds of organic acids, 47 kinds of flavonoids, 10 kinds of iridoids, and 21 kinds of saponins and 4 kinds of other compounds. After oral administered Jingyin Granules to rats, 48, 30, 25, 23, 45, 34, 39, 26, 19 prototype compounds were identified in serum, heart, liver, spleen, lung, kidney, brain, fat, and testicles, respectively. Meanwhile, an LC-MS based analytical method was established for simultaneous determination of chlorogenic acid, swertiamarin, caffeic acid, sweroside, liquiritin, prim-O-glucosylcimifugin, arctiin, 5-O-methylvisammioside and arctigenin in biological samples. The tissue distribution(serum, liver and lung) of these nine aim constituents in rats after oral administration of Jingyin Granules were investigated. It was found that these nine constituents could be quickly absorbed into circulation system and then distributed to liver and lung tissues. Except arctigenin, the exposure of other eight aim constituents to serum and lung was peaked at 1 h. At 1 h, the exposure of these components to lung tissue were ranked as follows: swertiamarin [(75 191.0±3 483.21) ng·g~(-1)]&gt;arctiin [(2 716.5±36.06) ng·g~(-1)]&gt;5-O-methylvisammioside [(585.1±0.71) ng·g~(-1)]&gt;arctigenin [(437.45±3.18) ng·g~(-1)]&gt;chlorogenic acid [(308.1±5.66) ng·g~(-1)]&gt;prim-O-glucosylcimifugin [(211.35±2.19) ng·g~(-1)]&gt;sweroside [(184.3±9.05) ng·g~(-1)]&gt;caffeic acid [(175.95±2.05) ng·g~(-1)]&gt;liquiritin [(174.78±153.34) ng·g~(-1)]. In summary, an UHPLC-Q-Exactive Orbitrap HR-MS method has been established for rapid and accurate identification of the constituents in Jingyin Granules, while the tissue distribution of nine major absorpted constituents were investigated in rats following oral administration of Jingyin Granules. These findings provided key information and guidance for further studies on pharmacodynamic substances and clinical applications of Jingyin Granules.

Started from the needs of clinical teaching and practice of acupuncture and moxibustion, based on the acupuncture Tongren education and assessment model, the virtual acupuncture teaching system was developed with the help of virtual reality (VR) technology, and applied to the course teaching of meridian and acupoint and needling and moxibustion method of Acupuncture Sciences . Compared with conventional teaching, this system can effectively improve practical operation test scores of students, meanwhile, it has higher interest, interactivity and helpfulness for knowledge learning, and improve independent learning ability, learning effect and memory depth, so student's satisfaction is higher.

Objective: To know the status of Enterobius vermicularis infection in children in Jiangxi Province in 2014, so as to provide the evidence for the formulation of prevention and control measures., Methods: A survey was performed according to the scheme of the 3rd Principal Human Parasites of Jiangxi Province in 2014. Based on the ecological regions, a stratified cluster sampling method was applied by the economic and geographic situation. There were 84 survey sites from 28 counties, and the basic data were also collected in the different investigation sites, and the round-end tube adhesive cellophane anal swab was used to examine E. vermicularis eggs for the children aged 3-6 years., Results: A total of 1 486 children aged 3-6 years were detected, the E. vermicularis infection rate was 13.73% (204/1 486), and the infection rates were 13.89% (114/821) and 13.53% (90/665) in the male and female, respectively. The infection rate in the different age groups showed a gradual rise then fall trend, the lowest infection rate was 10.05% (38/378) in the 3-year age group, and the highest infection rate was 18.24% (81/444) in the 5-year age group. The infection rates in the high, medium and low-income survey sites were 13.79% (87/631), 17.23% (51/296), and 11.81% (66/559), respectively. The E. vermicularis infection rates in the 4 ecological regions were from 12.34% to 17.74%, but there was no significant difference among the different ecological regions ( P > 0.05)., Conclusions: The status of E. vermicularis infection in children in Jiangxi Province is relatively serious, and therefore, the parasitic disease control sectors should continue to strengthen the monitoring and control work of E. vermicularis infection in children.

Objective: To evaluate the clinical effects of bone graft from the mandible in repairing orbital floor defects., Methods: Bone grafts from the mandible were used to treat 11 cases of orbital floor defects and followed up for 6-12 months., Results: The surgical incisions healed primarily in all 11 patients. The orbital floor structure was restored. No vision loss, limited eye movement, implant infection, or resorption were observed postoperatively, and no complications occurred in the supply area., Conclusions: Bone grafts from the mandible were an ideal material to repair orbital floor defects.

Objective: To investigate the clinical effects, indications and key techniques of debridement, internal fixation, and reconstruction with titanium mesh in lumbar tuberculosis via a posterior-only approach in adults., Methods: The clinical data of 26 patients with monosegment lumbar tuberculosis treated with surgery from March 2012 to March 2014 was retrospectively analyzed. Among them, 15 cases were male and 11 cases were female, and patients' age ranged from 21 to 68 years old (average, 44.7 years old). All patients suffered from back pain and/or pain with radiation to the legs. The clinical efficacy was evaluated based on the complications, erythrocyte sedimentation rate (ESR), imaging examination, and back and leg pain score of visual analogue scale (VAS)., Results: All operations were successful in 26 patients with an average operation time of (2.4±0.8) h (range from 2 to 4 h), with an average blood loss of (320±86) ml(range from 200 to 700 ml) .VAS was decreased from (5.7±1.4) points preoperatively to (1.6±0.5) points 2 weeks postoperatively ( P <0.01); and ESR was decreased from (42.8±10.4)mm/h preoperatively to (12.1±5.6)mm/h 3 months after surgery ( P <0.01). All the patients were followed up for 24 to 48 months with an average of(28.3±5.8) months. One patients suffered from the recurrence of TB and sinus tract formation at 2 months after surgery, and was cured by stronger anti-tuberculosis drugs, local debridement with drainage, and sinus tract healed at 3 months after operation. All intervertebral bone graft obtained fusion within 1 year after operation and no local recurrence of TB was found at final follow-up., Conclusions: Debridement, internal fixation, and reconstruction with titanium mesh via a posterior-only approach is a effective and safe method for the treatment of monosegment lumbar tuberculosis, especially for the patients with secondary spinal stenosis., Competing Interests: The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose.

Objective: To detect changes of thyroid stimulating hormone (TSH) with gender, age and levels of thyroid peroxidase antibodies (TPO-Ab) in patients with subclinical hypothyroidism, and to establish composite reference intervals for TSH and free thyroxine (FT4) in determination of subclinical hypothyroidism., Methods: From Oct. 2011 to July 2012, 7 964 healthy people (males: 4 789, females: 3 175) undergoing medical examinations were recruited. Their serum levels of TSH and FT4 were determined. Of those participants, 794 were also tested for TPO-Ab. The serum TSH and FT4 data were transformed into normal distributions, with outliers being eliminated and a correction for skewness (0. 909 and 0. 384, respectively) and kurtosis (2.605 and 1.947, respectively). The composite reference intervals were established according to the Mahalonobis distance formula., Results: Serum TSH increased with age and TPO-Ab. Using the conventional reference standards, 358 participants were identified with subclinical hypothyroidism, which included 230 at 41-70 years of age and 43 showing TPO-Ab positive. In contrast, using composite reference intervals, 301 participants were identified with subclinical hypothyroidism, which included 142 at 41-70 years of age and 25 showing TPO-Ab., Conclusion: The conventional cutoff values for FT4 and TSH separately lead to overestimation of the prevalence of subclinical thyroid disease.

Objective: To evaluate the efficacy and toxicity of paclitaxel with low-dose cisplatin and 5-fluorouracil continuous infusion in the treatment of advanced gastric carcinoma., Methods: The patients were treated with paclitaxel liposome 60 mg/m(2) i.v. gtt on d1, 8, 15, DDP 15 mg×m(-2)×d(-1) by i.v. gtt on d1-5, 5-Fu 500 mg×m(-2)×d(-1) by civ for 120 h, administered every 21 days., Results: Out of the whole group, 3 cases achieved CR, 29 cases achieved PR with an ORR of 54.2% and median TTP of 7.1 months. Out of 40 cases in the primary treatment, 3 cases achieved CR, 22 cases achieved PR with an ORR of 62.5% and median TTP of 7.6 months. Out of 20 evaluable retreated cases, no case achieved CR, 7 cases achieved PR with an ORR of 36.8% and median TTP 6.3 months. The main toxicities were hematological toxicities, nausea and vomiting of grade I-II., Conclusion: The combination regimen of paclitaxel, low-dose cisplatin and 5-fluorouracil is effective and well tolerated for patients with advanced gastric carcinoma, especially for primary treatment cases. It is worthy of further study.

Objective: To investigate the apoptosis of human breast cell line MCF-7 cells induced by gemcitabine and radiation., Methods: The MTT method was applied to study the growth inhibition of MCF-7 treated with gemcitabine, radiation, gemcitabine and radiation. The apoptosis index (AI) was analyzed by flow cytometry. The morphology of the MCF-7 cells apoptosis was observed by transmission electron microscopy., Results: When MCF-7 cells were treated with gemcitabine at different concentrations for 24 h, the cell growth inhibition rate was increased in a concentration-dependent manner. The apoptotic indexes (AI) of MCF-7 of four groups by flow cytometry revealed. The AI of (R+D) group was significantly different from those of the radiation group and the gemcitabine group (P<0.05). Condensed chromation, nuclear fragmentation and apoptotic body of MCF-7 cells were found by transmission electron microscope., Conclusion: The apoptosis of human breast cancer cell line, MCF-7 cells, could be induced by gemcitabine. Gemcitabine can significantly enhance the radiation-induced apoptosis of MCF-7 cells.

Objective: To evaluate the curative effects of AO clavicular hook plate in the treatment of dislocation of acromioclavicular joint and fracture of distal clavicle., Methods: We retrospectively analyzed the clinical data of 39 patients with acromioclavicular joint dislocation or distal clavicle fractures treated with clavicular hook plate: 16 suffered from dislocation of acromioclaviculr joint, 18 suffered from far end collarbone fractures, and 5 patients had both symptoms., Results: The 39 patients were followed up for 12 months averagely. All patients got good reduction and fixation. The acromioclavicular joint subluxation, breakage, and loosening of the clavicular hook plate were not observed. The acromioclavicular joint recovered quickly., Conclusion: AO clavicular hook plate is a good choice for acromioclavicular joint dislocation and distal clavicular fracture.