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In order to effectively provide guidance for the selection of aircraft dissimilar metals from the perspective of corrosion protection, the corrosion behavior of typical aircraft lap structures was studied by finite element simulation and corrosion test for the specific service environment of aircraft. The aluminum alloy, composite material and lap joints were subjected to cyclic immersion corrosion test in the laboratory. Then the galvanic corrosion law between aluminum alloy and composite was revealed by polarization curve measurement test, macroscopic and microscopic morphology observation, fatigue test and XRD measurement. Taking the electrochemical parameters measured by polarization curve as boundary conditions, the corrosion simulation model of lap joint was established. After 0 cycle and 10 cycles of cyclic immersion corrosion test, the results show that the self-corrosion potential and self-corrosion current density of aluminum alloy are -802 mV and 2.357×10-7 A/cm2, -872 mV and 1.477×10-6 A/cm2. The self-corrosion potential and self-corrosion current density of composite material are -240 mV and 6.217×10-7 A/cm2, -98 mV and 2.286×10-7 A/cm2, respectively. With the extension of the corrosion cycle, 7B04 aluminum alloy shows a trend of increasing self-corrosion rate and negative shift of self-corrosion potential, while composite material shows a trend of positive shift of self-corrosion potential and slowly increasing self-corrosion rate. The corrosion products of lap joints gradually increase and the corrosion degree becomes more and more serious. With the extension of corrosion cycle, fatigue life decreases and the depth of corrosion pits increases. The corrosion products include Al(OH)3, Al2O3, AlCl3. The simulation results of lap joints are in good agreement with cyclic immersion corrosion test results. The corrosion prone parts of the typical lap structure of the aircraft were given, and the law of galvanic corrosion was revealed, which points out the direction for the corrosion protection of the aircraft structure.

Deoxynivalenol(DON)，as a secondary metabolite of some fusarium species，has been harmful to the food and feed industry.To improve spore-producing ability of Bacillus subtilis，the fermentation pH，temperature，supplemental carbon source and duration of Bacillus subtilis that efficiently degraded DON were studied in 5L-quadruple fermenters.The best fermentation conditions were determined，the fermentation pH was controlled at 7.5 and the temperature was controlled by stages，kept at 37 ℃ for first 12 hours，then raised to 39 ℃ until the end; 10 g/L molasses was added once at the 12th hour，then the fermentation was terminated at the 30th hour.Under the optimal conditions，the number of spores could reach 2.9×1010 CFU/mL and the spores’ rate could reach 96.7%.The fermentation liquid were further prepared into direct inoculated microbial inoculum and applied to remove DON from grain processing by-products; Under the condition that dry matter content in the composite material culture medium was not more than 30%，and the inoculation amount of the bacterium preparation was more than 0.1%，DON in the grain by-products could be effectively removed by fermentation and the highest degradation rate could reach 98.8%.

In order to predict the elastic constants of 3D four-direction braided composites, unit cell model was established for braided composites with 20°,30°,45° braided angle respectively. The elastic properties of the interior cell and the surface cell were predicted using both the stiffness volume average method and the numerical analysis method, and all quasi-static tensile tests were performed on MTS machine. The experimental results, theoretical analysis and numerical simulation results were analyzed. It is found that the axial tensile modulus decreases,and the transverse tensile modulus and transverse shear stiffness increases with the increase of braiding angles because of the decrease of the component of carbon fiber stiffness in the direction of the carrier movement and the increase of the transverse component of carbon fiber stiffness. Tests reveal that the stress-strain curve for the extension tests of specimen of 20° braided angle exhibit linear elastic type, the stress-strain curve of 30° specimen shows nonlinear characters, the stress-strain curve of 45° specimen shows bilinear relation, but the transverse tensile stress-strain curves of all the specimens are basically linear. Combining the longitudinal and transverse tensile test results with the theoretical and numerical data, it is found that the stiffness volume average method and the numerical analysis methods are able to predict the stiffness in the direction of the carrier movement of 3D braided composites well. However, the prediction precision for the transverse stiffness of specimen is not satisfactory, mainly because these methods neglect the interface damage between the fiber and the matrix in tests.

In view of problem that traditional double-threshold spectrum sensing algorithm cannot make full use of information of sensing users between two thresholds, the paper proposed a double-threshold spectrum sensing algorithm based on D-S theory. When signal energy received by the sensing users lies between the two thresholds, the algorithm does not give judging result directly but makes local judgment, namely it uses D-S theory to make data fusion. Simulation result shows that detection probability of double-threshold spectrum sensing algorithm based on D-S theory is higher than one of the traditional double-threshold spectrum sensing algorithm, which improves performance of spectrum sensing.

Objective To evaluate the impact of DRG medical insurance payment reform on the quality development of a tertiary comprehensive hospital in Guangxi. Methods This study selected data on all inpatient settlement cases in the hospital from 2020 to 2021, and calculated the DRG grouping of all cases according to the national CHS-DRG version 1.0 grouping plan. The interruption time series analysis method was further used to analyze the level and trend changes of indicators after the DRG policy reform in hospitals in December 2020.These indicators included total weight, case group index, cost consumption index, time consumption index, average length of stay, average hospitalization cost per visit, etc. They were used to evaluate the hospital' s medical service capacity, medical service efficiency, and medical safety, in order to understand the quality of the hospital. Results A total of 72 089 cases were included in this study. Indicators such as cost consumption index (β = -0.242, P = 0.001), time consumption index (β = -0.119, P = 0.002), average length of stay (β = -1.543, P = 0.011), proportion of high incidence cases (β = -0.028, P = 0.026), and average cost of hospitalization (β = -3 669.366, P = 0.026) showed an immediate decrease during the implementation of DRG policy. Conclusion After implementing the DRG policy reform, the hospital has significantly improved the efficiency of medical services, but still faces the challenge of adjusting structure and increasing quality. [ABSTRACT FROM AUTHOR]

Objective To investigate the effect of fibroblast growth factor receptor 3 (FGFR3) on articular cartilage superficial zone cells (SPZCs). Methods C57 mice were randomly divided into two groups: a sham operated group (sham group) and a group of surgically induced unstable medial meniscus model group (DMM group). The histological morphology of articular cartilage was microscopied by Safranin O/Fast Green-stained in 4 weeks and 8 weeks after surgery. Apoptosis and FGFR3 protein expression were detected by immunohistochemical staining microscopy. Primary SPZCs were separated and randomly divided into control group and Fgfr3 knockdown treatment group. The genes and protein expression related to chondrocyte extra cellular matrix synthesis, degradation and chondrocytehypertrophy were detected by RT-qPCR and Western blot. Results Compared with the sham group, the keen cartilage of mice in DMM group showed a pioneer damage of SPZCs after surgery; Immunohistochemistry results showed an increase in chondrocyte apoptosis and a decrease in expression of MMP-13 and FGFR3(P＜0.05). Primary SPZCs were transfected with small interfering RNA (siRNA) to knockdown Fgfr3; RT-qPCR results showed that the mRNA expression of genes related to the synthesis of cartilage extracellular matrix aggrecan and Col2 was reduced; And the mRNA expression of extracellular matrix degradation-related genes Mmp13 and Adamts5 was increased. The mRNA expression of chondrocyte hypertrophy-related genes Col10 and Mmp13 was increased. Western blot and RT-qPCR results were consistent and the expression l of MMP13 protein was significantly increased, while the expression of collagen Ⅱ and aggrecan protein was significantly decreased (P＜0.05). Conclusions Knockdown of Fgfr3 induces damage to primary SPZCs in mice resulting in early osteoarthritis (OA) development.

The experiment was conducted to compare the effect of different sources pigment additives on growth performance, slaughter performance and skin coloration of Danzhou chickens. A total of two hundred and ten 150-day-old Danzhou chickens with similar body weight were randomly divided into seven groups, with five replicates in each group and six chickens in each replicate. Danzhou chickens in control group were fed with basal diet, chickens in group I and group II were given a basal diet supplemented with 10 mg/kg carophyll red + 20 mg/kg carophyll yellow, 20 mg/kg carophyll red + 40 mg/kg carophyll yellow, respectively, chickens in group III and group IV were given a basal diet added 100, 200 mg/kg of turmeric extract, respectively, and chickens in group V and group VI were given a basal diet supplemented with 500, 1 000 mg/kg of marigold extract. The trial period was 28 d. The results showed that compared with control group, the growth performance and slaughter performance of Danzhou chickens in each experimental group was not significant (P>0.05). On the 28th day, b* value of back skin of Danzhou chickens in group II and group VI was significantly higher than that in control group (P<0.05), and abdominal skin b* value of Danzhou chickens in group II were higher than control group (P<0.05). Compared with control group, the abdominal fat percentage of Danzhou chickens in group IV was significantly decreased (P<0.05). The study indicates that the addition of three kinds of pigment additives to diet can improve the skin pigmentation of Danzhou chickens in different degrees. [ABSTRACT FROM AUTHOR]

Abstract [Objective] The study aims to investigate the soil seed bank and seedling regeneration characteristics of Amygdalus ledebouriana in Xinjiang, and to explore the limiting factors affecting the population regeneration of A . ledebouriana. [Methods] A . ledebouriana in the Ta􀆳e Basin of Xinjiang was used as the research object, and the soil seed bank and seedling regeneration were studied by means of field plot investigation, soil sample collection, and seedling number and grade statistics under the mother plant. [Results] (1) The average density of seeds in the soil seed bank of A . ledebouriana was 96.45 m2. The complete seed density of the Tuoli population was the highest, and the density of seeds eaten by the Yumin population was the highest, while the insect-eaten seeds only appeared in the Tacheng population. (2) The seeds of A . ledebouriana were mainly distributed in the litter layer, accounting for 56.29% of the total seeds, S2 (0-5 cm) soil layer accounted for 29.07%, and S3 (5-10 cm) soil layer accounted for 14.65%. The horizontal diffusion distance of soil seeds was proportional to the slope of A . ledebouriana. (3) No seedlings were found in the investigated A . ledebouriana seedlings. Grade Ⅰ seedlings accounted for 51.12% of the total number of seedlings. A . ledebouriana seedlings were concentrated in the range of 50 cm from the base of the mother plant. [Conclusion] The distribution characteristics of soil seed bank of A . ledebouriana is near the mother plant and the surface, and the characteristics of seedling regeneration is also near the mother plant distribution. Under natural conditions, gnawed seeds, insect-infested seeds, and niche loss are the main reasons why A . ledebouriana seedlings cannot germinate and the regeneration of seedlings is limited.

Objective: This stydy aimed to develop a new type of fried potato ball and evaluate its quality. Methods: In this study, potatoes were used as the main raw materials to make mashed potatoes after cooking and then fried into potato balls. The effects of whey protein addition on color difference, texture properties, rheological properties, sensory quality and starch digestibility of fried potato balls were explored. Results: Compared with non-whey protein addition, the supplementation of whey protein could significantly improve the L* （brightness value）, a* （redness value）, and the cohesion, adhesion, and elasticity of potato balls （P＜0.05）. The higher the amount of whey protein powder （0 ~ 2.5 g/100 g）, the lower the hardness and the higher the elasticity of potato balls. The addition of whey protein can promote the starch digestibility of fried potato balls. Conclusion: The color, taste, hardness, elasticity and other comprehensive qualities of fried potato balls were the best when the whey protein supplemental level was 2 g/100 g.

ObjectiveTo investigate the status of different antiretroviral therapy（ART） initiation times in patients with HIV/AIDS and analyze the relevant characteristics and influencing factors of delayed ART.MethodsFrom December 2018 to December 2020， a survey was conducted among adult HIV/AIDS patients treated in 28 designated AIDS prevention and treatment institutions in Beijing， Shanghai， Guangdong， Jiangsu， Henan， Jiangxi， Guangxi， Yunnan and other places. Data of the basic demographic information， lifestyle and chronic disease prevalence， and characteristics of diagnosis and treatment were collected. The characteristics and related factors of delayed ART were compared and analyzed.ResultsThe median age of 1 741 patients was 41 years old （IQR： 32‒52）. The initial CD4 count of most patients was less than 200 cells·μL-1（51.4%）. Among them， 1 027 patients had delayed ART （59.0%）， and the association between ART initiation time and initial CD4 count varied with the time of diagnosis of HIV infection. Multivariate logistic analysis showed that the older age （aOR=0.99， 95%CI： 0.98‒0.99） was associated with a higher rate of starting ART within 1 month after diagnosis， while those diagnosed before 2017 and with the initial CD4 count >200 cells·μL-1 were more likely to delay ART. Delayed initiation of ART may be a risk factor for poor sleep quality and co-infection in HIV/AIDS patients.ConclusionWith the expansion of free ART in China， the proportion of delayed ART with HIV/AIDS shows a downward trend. Timely ART management should be strengthened for the young HIV/AIDS patients and patients with high CD4 counts.

Tall object not only has a high probability of being struck by downward lightning, but also is easy to trigger upward lightning. Comparing with 2D optical observation, reconstructed 3D observation by dual-station optical observation can better reflect the real characteristics of the lightning channel. Based on the synchronous dual-station optical observations from the Tall-Object Lightning Observatory in Guangzhou (TOLOG), an upward lightning triggered by a nearby positive cloud-to-ground (CG) flash at Guangzhou Tower is investigated, and 2D and 3D development characteristics of the upward leader are compared.The result shows that the length of 3D channel is 5.4 km, which is 1.5 times of 2D channel. 3D channel is developed at a height of more than 4.6 km in the vertical direction and about 800 m in the horizontal direction. 2D speed ranges from 1.8×104 to 4.5×105 m·s-1, with an average of 1.8×105 m·s-1. 3D speed ranges from 3.8×104 to 7.2×105 m·s-1, with an average value of 2.8×105 m·s-1. Within 10 ms after the leader initiation, 3D and 2D speeds show roughly the same trend. After 10 ms, 2D rate decreases significantly and changes little over time, while 3D speed shows an obvious irregular fluctuation with time. The ratio of 3D speed and 2D speed ranges from 1 to 4.7, with an average of 1.5. The ratio remains stable at 1-2 for the first 10 ms after leader initiation and then shows irregular fluctuations with time. In fact, due to the change of horizontal development direction of the channel 10 ms after the leader initiation, the distance between the channel and the station-1 increases rapidly, leading to increasing speed difference between 3D and 2D observations. The cause for the fluctuation of 3D speed and 2D speed ratio is that the angle between the development direction of the channel and the sight direction of the observation station changes greatly. The results of 2D and 3D vary greatly at a certain stage of upward leader development, which further proves the importance of analyzing 3D development characteristics of lightning.

Almond oil is a functional vegetable oil obtained from apricot kernel by pressing, extracting and other technologies, which has the effects of anti-oxidation, anti-inflammation, anti-tumor and prevention of cardiovascular diseases. In this review, the extraction process, nutritional composition and health effect of almond oil were summarized, and the future development tendency of almond oil was prospected.

Morphing wing is one of the important development directions of future aircraft design, and the study of in-plane deformation of the morphing wing surface has received widespread attention. In this paper, four aspects in-cluding variable span length, variable sweep angle, variable chord length and combined deformation are analyzed to describe the current status of domestic and international research on in-plane morphing wings, summarize the defor-mation mechanism and its advantages and disadvantages, and analyze the future development trend of morphing wing. In view of the current research situation and the application requirements of the morphing wing, the key tech-nologies of the morphing wing are proposed, including the morphing skin technology, morphing mechanism, intelli-gent actuator, sensor and control network. The application requirements of each key technology and the existing problems are analyzed furthermore. The future development direction is summarized, which can provide some references for the design and application realization of in-plane morphing wings.

Based on V93000 ATE, a test system using external power boost conversion module and programmable gain instrumentation operational amplifier was designed to meet the requirements of mass production of multi-sites ADC with large-swing and high-precision. The theoretical and test results show that the ADC test system can generate 29.4 V ramp and 29.1 V sine wave signals with peak to peak value. The SNR of test signal is better than 105 dB and THD is better than -103 dB, which can meet the test requirements of 16 bit high-precision and ±10 V high input swing multi-sites ADC.

Introduction: The aim of current study was to develop a questionnaire with good reliability and validity for measuring Taiwanese adolescents' total and domain-specific time spent engaging in various sedentary behaviors. Methods: Ninety-seven junior high school students in Changhua City participated in this study. They completed the questionnaire twice over a one-week period and wore a tri-axial accelerometer during this period. The test-retest reliability was examined by Spearman's rank correlation and paired-samples t-test. The criterion-related validity in total sedentary time per day was first examined by Spearman's rank correlation between self-report measurement and accelerometer-assessed measurement. In addition, a Bland-Altman Plot was used to compare the consistency between these two measurements. Results: The results showed that the mean self-reported total sedentary time was 6.11 (SD = 2.98) hours. With regard to the test-retest reliability, there was no significant difference in total and domain specific time of self-report sedentary behavior, except for "Studying/Doing homework." The Spearman's rank correlation coefficients of the total sedentary time per day, and the two domain specific items, "Using a computer for fun" and "Playing/practicing a musical instrument," were higher than the recommended level 0.70. The coefficients of the other five items, "Using the phone," "Out-of-school-hours tutoring," "Reading for fun," "Passive transport," and "Using a computer for homework," ranged between 0.60 and 0.69. The reliability of the remaining Three items-"Studying/Doing homework," "Watching TV," and "Doing crafts or others," ranged from 0.50 to 0.59. Results also showed that there was a significant correlation in total sedentary time between self-report measurement and accelerometer-assessed measurement (Spearman's ρ = 0.55), indicating a good criterion-related validity. According to Bland-Altman Plot, compared to accelerometer- assessed measurement, the self-report questionnaire underestimated the total sedentary time per day about 1.36 hours, which was better (i.e., less underestimated) than previous research. Conclusion: The current study showed the preliminary evidence that our questionnaire was useful for measuring the sedentary behavior in Taiwanese adolescents with acceptable reliability and validity. [ABSTRACT FROM AUTHOR]

Objective To explore the influencing factors for delayed facial palsy after microvascular decompression for hemifacial spasm. Methods We retrospectively analyzed 306 cases of hemifacial spasm undergoing microvascular decompression. The cases were divided into facial paralysis group and control group according to whether postoperative delayed facial paralysis occurred, comparing gender, age, disease duration, hypertension, diabetes, old cerebral infarction, spasm position, pre-operation Cohen grade, number of responsible vessels, severe indentation between two groups. Single factor and multivariate stepwise Logistic regression analysis were used to determine the risk factors for delayed facial palsy after microvascular decompression. Results Delayed facial palsy occurred in 21 cases (6.86% ). House brackmann (H-B) grade III in 2 cases, IV in 17 cases, V in 2 cases. Multivariate stepwise Logistic regression analysis showed that disease duration (OR = 1.130, 95%CI: 1.004-1.271; P = 0.042) and severe indentation (OR = 0.167, 95%CI: 0.056-0.495; P = 0.001) were the risk factors for delayed facial palsy after microvascular decompression. During 0.50-5.00 years' follow - up, 19 patients with delayed faoial palsy recovered completely, and 2 patients recovered to H-B grade II. Conclusions Severe indentation and disease duration were risk factors for delayed facial palsy after microvascular decompression. Delayed facial palsy is generally self-healing with a good prognosis. [ABSTRACT FROM AUTHOR]

Objective To compare the efficacy of local anesthesia and general anesthesia of subthalamic nucleus deep brain stimulation (STN-DBS) for Parkinson's disease (PD). Methods Forty PD patients who underwent bilateral STN - DBS from January 2015 to January 2018 were retrospectively analyzed. Twenty-two patients underwent local anesthesia and 18 patients underwent general anesthesia. Pre- and post-operative Unified Parkinson's Disease Rating Scale-III (UPDRS-III), Hoehn-Yahr, Activities of Daily Living (ADL), Wechsler Adult Intelligence Scale (WAIS), Wechsler Memory Scale (WMS), Hamilton Depression Rating Scale (HAMD)-17 and Hamilton Anxiety Rating Scale (HAMA)-14 were used to assess the motor symptoms, daily living function, cognitive function, memory, anxiety and depression. Results The target deviation of the second electrode in general anesthesia group was lower than that in local anesthesia group [(0.98 ± 0.39) mm vs. (1.21 ± 0.35) mm; t = - 2.041, P = 0.048], the target deviation of the first electrode was not statistically significant [(0.96 ± 0.29) mm vs. (1.01 ± 0.35) mm; t = - 0.496, P = 0.623]. At 6, 12, and 24 months after surgery, the "on" and "off" UPDRS-III scores (P = 0.001, for all) and Hoehn-Yahr (P = 0.001, for all) in the general anesthesia group and the local anesthesia group were all significantly decreased compared with baseline, ADL score significanly increased (P = 0.001, for all). There were no significant differences in "on" and "off" UPDRS-III, Hoehn-Yahr, ADL, WAIS and WMS scores between 2 groups (P > 0.05, for all). One day after surgery, the HAMA-14 in the local anesthesia group was higher than baseline (P = 0.027), in the general anesthesia group, HAMD-17 (P = 0.008) and HAMA-14 (P = 0.001) scores were lower than 1 d before surgery. The HAMD-17 (P = 0.001, for all) and HAMA - 14 (P = 0.001, for all) of 2 groups at 6, 12 and 24 months after surgery were all lower than baseline, 1 d before and 1 d after surgery. HAMD-17 score in the general anesthesia group was lower than the local anesthesia group (P = 0.048). Conclusions Both general anesthesia and local anesthesia STN- DBS can significantly improve PD motor symptoms and quality of life, as well as relieve the depression and anxiety symptoms, without affecting cognitive function and memory. Attention should be paid to mood fluctuations in using different anesthesia during the perioperative period. Choice of anesthesia method should be based on the patient's condition and indications. [ABSTRACT FROM AUTHOR]

The complement system is a self-protection mechanism of the human body. The abnormal activation of the complement system is involved in the occurrence and development of various diseases. The application of complement inhibitors in many rare diseases was a milestone in leading to the progress of such disease as paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), and others. Recently, the application of complement inhibitors has gradually expanded to other complement-related diseases. This review summarizes the literature on the current application of complement inhibitors in rare diseases and looks into the prospects of the application in the rare diseases.

Maintaining the normal operation of inlet filtration system is of great significance to ensure the operation efficiency of gas turbine unit. The maintenance economic benefit analysis model of gas turbine inlet filtration system was established, and the total maintenance cost was divided into three parts, i. e., initial cost, shutdown cost and performance degradation cost. Secondly, based on the model, the optimization methods of filter replacement and compressor washing maintenance cycle were proposed. Finally, the adjustment mode of maintenance strategy under the condition of abnormal degradation of inlet filtration system was explored. The results show that the economic benefits of gas turbine operation can be significantly improved by combining the degradation state evaluation of inlet filtration system and adjusting the maintenance cycle accordingly.

Background Anti - CV2/CRMP5 antibodies - associated paraneoplastic peripheral neuropathy (PPN) is a poorly understood disease due to its rarity. This study aimed to summarize the clinical manifestations, electrophysiological and pathological characteristics of anti-CV2/CRMP5 antibodies-associated PPN and reviewed related literatures, so as to improve the understandings on this disease. Methods The clinical data of 2 patients with anti - CV2/CRMP5 antibodies - associated PPN were retrospectively reviewed, including their clinical manifestations, electrophysiological and pathological characteristics, treatment and follow-up. Results Case 1 was a 52-year-old woman who initially presented with a 3-year history of slowly progressive numbness of limbs, which presented from right leg and gradually spread to her left arm and right ring finger and little finger. Then she suffered from weakness of left leg, weakened muscle strength of left hand and had difficultly in lifting left arm. Serum anti - CV2/CRMP5 antibodies were weakly positive, and anti-Hu, Yo, Ri, amphiphysin antibodies were negative. EMG showed peripheral neurogenic damage. Nerve tissue biopsy showed chronic severe active axonal peripheral neuropathy. There was no improvement after two courses of intravenous immunoglobulin (IVIg) and then she received steroid pulse treatment and sequential therapy. The symptom was still not improved 2 months after discharge, and oral azathioprine was added. Follow-up in one year, the numbness and weakness were improved. Case 2 was an 18-year-old man who presented with one-month history of limbs weakness with fluctuating symptoms and positive results of fatigue test. Serum anti-CV2/CRMP5 antibodies were positive. Acetylcholine receptor antibodies (AchR-Ab) was 27.47 nmol/L, and cerebrospinal fluid (CSF) protein was 1360 mg/L. EMG showed symmetrical involvement of sensorimotor nerves of all limbs, mainly demyelination. Repetitive nerve stimulation (RNS) showed low - frequency amplitude decreased progressively. Needle biopsy of thymus showed type B3 thymoma. The patient was diagnosed as myasthenia gravis (MS), peripheral neuropathy and type B3 thymoma. He was treated by IVIg, oral pyridostigmine bromide and chemotherapy. EMG 10 months after discharge showed worsened neurogenic damage of four limbs. Serum anti-CV2/CRMP5 antibodies were still positive. Conclusions Anti-CV2/ CRMP5 antibodies -- associated paraneoplastic peripheral neuropathy patients can present a symmetric or asymmetric sensorimotor peripheral neuropathy with either axonal or demyelinating damage. Immunotherapy maybe effective. [ABSTRACT FROM AUTHOR]

Objective To investigate the features of clinical phenotype and gene mutation of progressive myoclonic epilepsy (PME). Methods and Results The main clinical features of a 43-year-old man were photosensitive seizures, progressive cerebellar ataxia and peripheral neuropathy. Skeletal muscle biopsy showed typical ragged - red fibers (RRF), large amount of mitochondria accumulating under the muscular membrane, and tubular or concentric mitochondrial cristae. A heterozygous c.8344A > G mutation of mitochondrial DNA (mtDNA) was identified from peripheral whole blood cells. The final diagnosis was myoclonic epilepsy with ragged-red fibers (MERRF). Conclusions PMEs are a group of disorders with similar clinical presentations and individual characteristics. The diagnosis of PME should be considered by analyzing the clinical features, pathological results and gene detection. MERRF presents highly clinical heterogeneous features. [ABSTRACT FROM AUTHOR]

The Modified-ASME model is mainly used for the failure assessment of ultra-fine particle nuclear graphite, but the model has not yet passed experimental verification. This article first uses ABAQUS software to establish a four-point stress experimental model to verify the Modified-ASME model. It is found that the error between the calculation result of the model and the experiment is more than 20%, which could not meet the requirement that the error in engineering design should be less than 18%. Therefore, the model should be optimized. This paper optimizes the Modified-ASME model based on the Brazilian disk experiment and the correction of Weibull parameters. The error between the optimized Modified-ASME model calculation results and the experiment is within 10%, which meets the design requirements.

Objective To investigate the transcriptomic characteristics of the brain tissue in patients with Rasmussen encephalitis (RE). Methods RNA-seq technique was used to detect the gene expression profiles in the brain tissues from 4 patients with RE and 4 with temporal lobe epilepsy (TLE) admitted to Sanbo Brain Hospital, Capital Medical University between April, 2008 and December, 2013. Results Cluster analysis showed significant differences in the differentially expressed genes (DEGs) in the brain tissue between the patients with RE and those with TLE. We identified a total of 1 285 DEGs, of which 782 (60.9%) were down-regulated and 503 (39.1%) were up-regulated in RE. The up-regulated DEGs were mainly enriched in the pathways associated with neuronal signal transduction, possibly in relation with frequent seizures in patients with RE; the down-regulated DEGs were mainly enriched in the pathways associated with cytoskeleton, cell cycle and chemotaxis, which may be related to neuronal loss and regeneration and immune responses to infection by some pathogens in the brain tissue of patients with RE. TAS2R40, HTR4 and NAP1L2 were identified as the key up-regulated DEGs, and CXXC1, SEPTIN8 and CCR7 as the key down-regulated DEGs. Conclusion The brain tissue of patients with RE shows characteristic transcriptomic changes, and the DEGs are mainly enriched in neuronal signal transduction, cell cycle and chemotaxis-related pathways.

There is a lot of dynamic knowledge in real world, the traditional semantic Web ontology and context-aware system were not suitable to deal with the dynamic knowledge. To solve this problem, this paper proposed a pragmatic Web driven context-aware system by virtue of the advantage of pragmatic Web in expressing dynamic knowledge, and designed its framework. This system employed an efficient context capturing technique to improve the accuracy of captured context information, and deduced the high-level context with decision capability by reasoning. Finally, achieving user-centric personalizes recommendation service by a method of agent based context-aware service discovery. [ABSTRACT FROM AUTHOR]

At present, the volume of ontology's Abox in semantic Web of things is always too large, which is not easy for users to understand or reason about ontology. To solve this problem, this paper proposed a method based on equivalence relation. Summary ontology's Abox through searching, mapping and deleting the equivalence individuals. It designed and implemented a prototype system of ontology Abox's summarization. Some experimental examples of public ontologies prove that on the premise of reserving the original semantics, this method can streamline the redundant assertions of ontology's Abox, decrease ontology's volume, reduce storage pressure, so that it can be more convenient for ontology understanding, reusing and other ontology-related operations. [ABSTRACT FROM AUTHOR]

Phoneme segmentation is often necessary in research of Tibetan TTS or phonetics. Artificial segmentation is a hard job and time-consuming. The acoustic model of Tibetan language is not precise or robust enough because of resource-deficiency. Therefore, it is not precise enough when the method of auto-segmentation is adopted. Lhasa dialect of Tibetan is chosen as the study object. Phone set and dictionary of Tibetan are established. Common phones are obtained on the basis of distance between phone models. GMM-HMM models of English and Lhasa Tibetan are fused. Silences and short pauses are autojudged. Words network is established and then expanded to be a models (or monophones) network. All frames of parameters are segmented and aligned to sates of models by using Viterbi algorithm. Experiments demonstrate that phones are segmented and the result is better than the method of using pure Tibetan models. [ABSTRACT FROM AUTHOR]

In order to research the vertical mechanical behavior of steel frame-prefabricated concrete lateral resistance wall fabricated structure, a full-scale specimen consisting of steel frame and prefabricated concrete lateral resistance wall was tested under vertical load. The vertical load distribution relationship between steel frame and lateral resistance wall and the changing law of frame beams deflection were investigated along with the influencing factors analysis by ABAQUS finite element software during the construction and the use phase. The results show that frame columns withstand most of the vertical load, and lateral resistance wall withstands minor vertical load during the construction and installation phase. In the use phase, frame columns and lateral resistance wall share the vertical load together. The vertical load sharing ratios of frame columns and lateral resistance wall are 32% and 68%, respectively. In the construction and installation phase, minor pre-tightening force and bottom-up bolt screwing order make the wall withstand smaller vertical load. In the use phase, the vertical load sharing ratio of lateral resistance wall is raised as the wall width to beam span ratio is increased, and the non-centered arrangement of lateral resistance wall brings out uneven share of the vertical load for the frame columns. [ABSTRACT FROM AUTHOR]

In geosynchronous synthetic aperture radar (GEO SAR), due to the high orbit curvature, the traditional slant range mode cannot descript the "near-far-near" slant range history at apogee. This paper presented a modified range model in which curvature was negative to descript the range history at apogee in GEO SAR accurately. Based on the modified model, an accurate two-dimension spectrum of GEO SAR echo was obtained. Then, a modified Chirp-Scaling algorithm for apogee in GEO SAR was presented. At the same time, in order to focus wide swath in GEO SAR, the phase error caused by the linear variation of velocity in range direction can be compensated in azimuth processing. Finally, the simulation result of a large scene (100 km x 100 km) proves that the CS algorithm based on the modified range model can achieve the focusing image of GEO SAR at apogee. [ABSTRACT FROM AUTHOR]

The Wlvnt fiber fineness discussion system was used to study the relationship between the morphology of medullar layer, the column number of the medulla, the medulla index and the fiber fineness. The formate was used for rabbit hair and the three -dimensional structure of the medulla layer was observed. The results show that regardless of the fineness, rabbit fiber contains the medulla layer, just the morphology, the column number, the width of the medulla layer are different. With the increase of rabbit fiber fineness, the morphology of medulla layer varies from the irregular dot, discontinuous medulla to the multiple columns medulla, and the column number of medulla grows in ladder type and the medulla index increases. [ABSTRACT FROM AUTHOR]

The aircraft structure is an important part of the air-frame, and its manufacturing process is complex. It is difficult to recognize the target in the computer-aided process planning(CAPP) system. According to the characteristics of structural parts, CAPP system is constructed based on manufacturing feature of air-frame parts to improve the production efficiency. Six manufacturing features are summed up according to the machining process by researching on classification of common aircraft structural parts. In the VC++6.0 environment, a coding system based on manufacturing feature is designed according to OPITZ standard. The step retrieval algorithm is designed for feature recognition between target parts and entity library parts. The similarity of features is achieved between the target parts and the physical library parts. Taking the frame parts with 44 slots as an example, 40 manufacturing features are automatically identified by the algorithm program. The automatic recognition rate is 91%. The result shows the feasibility and correctness of the algorithm in CAPP system.

Probability distribution of monophones and triphones in Lhasa Tibetan are calculated and the necessity of establishinga contextuai acoustic modei in AST for Lhasa Tibetan is analyzed. Phoneme is chosen as basic unit for acoustic models. According to the characteristics of Tibetan, a pronunciation dictionary based on single syllable is established. Main issues and algorithms for triphone models based on decision tree are discussed. According to IPAs and characteristics of Lhasa dialect, 38 phoneme sub-sets and question sets for triphone modeling are established. 8170 sentences of 20 speakers are recorded to train the models. Contextual continuous Hidden Markov Models/HMM) based on triphones are es-tablished and trained on HTK platform. The recognition results under different sates number and mixtures are analyzed. And the framework for large-vocabulary continuous speech recognition of Lhasa Dialect is established. [ABSTRACT FROM AUTHOR]

Background: The Ministries of Justice and Education have implemented adolescent substance abuse prevention programs for many years. Rates of substance abuse among high school students continue to rise in spite of such programs. Purpose: This study investigates adolescents' substance abuse-related knowledge and attitudes and self-confidence to resist substance use in order to identify predictive factors of poor adolescent resistance to substance use. Methods: A cross-sectional study survey gathered data on substance abuse-related knowledge and attitudes and self-confidence to resist substance use from 243 second-year senior high school students studying at two schools in northern Taiwan. Results: Participants were most knowledgeable about tobacco (80.2%), followed by alcohol (72.0%), ecstasy (56.0%), and marijuana (30.0%). Only 19.3% demonstrated an understanding of the harmful effects of using Ketamine. A 10-point Likert scale measured participant substance use attitudes. Alcohol was the substance participants were most willing to use (2.18 ± 3.27), followed by tobacco (0.66 ± 2.19), ecstasy (0.45 ± 1.88), Ketamine (0.43 ± 1.93), and marijuana (0.38 ± 1.83). Participants had higher awareness of the harmful effects of Ketamine (t = -2.37, p = .018), marijuana (t = -2.33, p = .021), and tobacco (t = -2.02, p = .044), with participants reporting greater self-confidence to resist using these three substances. Multiple regression analysis found the three most important factors affecting participant self-confidence to resist substance use to be gender (ß = .26, p < .001), knowledge about the substance (ß = .15, p = .028), and attitude toward substance use (ß = -.20, p < .001). Conclusions / Implications for Practice: Level of harmful effects knowledge and attitudes toward use varied among the various substances considered in this paper. Being female, having strong knowledge about the substance, and negative attitude toward substance use correlated with higher levels of self-confidence to resist substance use. Study results will be used in ongoing research designed to establish an empirical basis for adolescent substance use prevention and research, the results of which may be used directly by school nurses and military training education nurses. [ABSTRACT FROM AUTHOR]

The effects of hygrothermal aging on the interlaminar shear strength of T700/TDE-85 composites were studied by short-beam method and double-incision method. The relationship between moisture absorption and aging time was discussed, and the fracture surface morphology was analyzed. The experimental results show that the moisture absorption law of the two specimens is in accordance with Fickle's second law, but the saturated moisture absorption rate and moisture absorption time are different. The moisture absorption rates and saturated moisture absorption rates of the specimens of double incision method are higher than those of the short beam method. The interlaminar strength of double-incision test is more obvious than that of short-beam under hygrothermal aging conditions, the interlaminar shear strength retention rates of short-beam method's specimens are 74.5%, 61.0%, 53.2% and 50.6% at 500 h intervals and the interlaminar shear strength retention rates of double-incision method's specimens are 60.9%, 38.3%, 42.6% and 33.0% at 500 h intervals. The failure mode of short-beam specimen is more complicated than that of double-incision with the increase of hygrothermal aging time.

Patients with cerebral hemorrhage in basal ganglia were treated with hemocoagulase combined with aminomethylbenzoic acid from May 2010 to April 2013 in our hospital, and hematoma volume and neurological impairment were compared with the control group before and after treatment. This study confirmed that hemocoagulase combined with aninomethylbenzoic acid is a safe and effective method for cerebral hemorrhage in basal ganglia. It can effectively prevent the hematoma enlargement and improve neurological function and prognosis. [ABSTRACT FROM AUTHOR]

A location prediction algorithm based on movement tendency (LP-MT) was proposed, which not only buils moving object's historical activity model borrowing from Markov thinking, but also added movement tendency as an important reference of location prediction. Besides, each of the historical stay regions was considered as a candidate of future location. According to the characteristics of the future location, algorithm results were divided into prediction locations and recommendation locations. Experiment results on real dataset show LP-MT method can ensure good efficiency and improve the accuracy by 10% compared with the existing algorithms.

It is to address torquing an individual tooth using a gate spring. The gate spring is made of a rectangular stainless steal wire, in the shape of a gate, which is incorporated to the arehwire by spot welding. Torque is generated by the combined effects of the gate spring and the arehwire. After 2 - 3 months, the gate spring can obviously torque individual tooth. [ABSTRACT FROM AUTHOR]