1. The research progress of macrophage glycolysis in sepsis.
- Author
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MA Xinglong, ZHOU Changjian, XIE Peng, SHEN Songxuan, MIAO Yanmei, SONG Jiamei, and XIE Leiyu
- Subjects
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GLYCOLYSIS , *SEPSIS , *MACROPHAGES , *INFLAMMATION , *IMMUNE response - Abstract
Sepsis is a heterogeneous syndrome. It is caused by infections, attributing to immune dysfunction pathologically. The disease is characterized by macrophage-mediated inflammation and immune response throughout its development. During septic development, macrophages metabolize crucially with glycolysis remarkably enhanced. The glycolystic enhancement facilitates septic development by promoting the inflammatory response of macrophages and altering their phenotype. Therefore, direct or indirect inhibition of macrophagic glycolysis can alleviate sepsis and neutralize damages to organs functionally, promoting the polarization of anti-inflammatory phenotype. In this review, we aim to investigate the relationship between macrophagic glycolysis and sepsis, focusing on researching into relevant molecular mechanisms by which glycolysis is regulated for treating sepsis. It is concluded that interfering with macrophagic glycolysis may serve as a novel therapeutic strategy for treating sepsis. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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