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Objective To summarize the clinical characteristics of peripheral nerve hyperexcitability syndrome (PNHS). Methods and Results Ten patients with PNHS were admitted to He'nan Provincial People's Hospital from October 2018 to April 2022, with the clinical phenotypes of Morvan syndrome in 5 cases, Issacs syndrome in 4 cases, and cramp-fasciculation syndrome (CFS) in one case. There were 10 cases with clinical manifestations of muscle twitching, 8 of dysautonomia, 7 of central nervous system symptoms, 7 of limb weakness, 6 of sensory deficits, and 2 of cramping and muscle stiffness. Five cases were positive for autoimmune antibodies. Two cases had MRI abnormalities located in the brainstem, left occipital lobe and right thalamus. Ten cases had EMG abnormalities, including afterdischarges of F - wave in 10 cases, unit potential of spontaneous motion abnormalities in 10 cases, fasciculation potentials in 10 cases, myokymic discharges in 8 cases, and neuromyotonic and myokymic discharges in 3 cases. Three cases underwent only symptomatic therapy, and 7 cases underwent symptomatic therapy and immunomodulatory treatments. Except for one case who lost of follow-up, 5 cases had a good prognosis, 2 cases with poor prognosis, and 2 cases died. Conclusions PNHS is a heterogeneous group of clinical manifestations. Electrophysiological appearance of afterdischarges may be a sensitive indicator for the diagnosis of PNHS.

Temperature swing adsorption is one of most important means of the enrichment of xenon, and temperature is an important factor affecting adsorbent performance for xenon. In this paper, the dynamic adsorption experimental platform at ultra-low temperatures was designed, based on which the adsorption characteristics of carbon molecular sieve for xenon was studied within the temperature range of -110 ℃ to -60 ℃. The effects of xenon volume fraction, gas flow rate, inlet pressure, and inner diameter of the adsorption column on xenon adsorption performance were analyzed at -110 ℃. The results show that at -110 ℃, the volume fraction of xenon and flow rate have the most significant effects on the dynamic adsorption coefficient of xenon, while the effects of the inlet pressure and the inner diameter of the adsorption column are less than the above two factors within a certain range.

Territorial space ecological restoration has become a significant strategy for the construction of China's ecological civilization. It is also an important strategic task related to national ecological security and human well-being. The continuous expansion of space in urban agglomerations and the high-intensity development of cities have exacerbated the fragmentation of natural landscapes. The ecological security of urban agglomerations and the ecological restoration of territorial spaces have become key issues of common concern to the government and scholars. Currently, the research on ecological restoration of territorial space mostly focuses on the identification of ecological restoration areas based on the key components of ecological security patterns and rarely discusses the coordinated protection and restoration of urban agglomerations by combining the ecological security patterns with human activities. It is particularly necessary to identify the ecological restoration areas and build a technical paradigm for ecological protection and territorial space restoration that can provide a basic support for the ecological integration, construction, and sustainable development of urban agglomerations. Based on ecological network construction and human disturbance assessment, this study diagnoses the territorial space ecological restoration areas of Guangdong-Hong Kong-Macao Greater Bay Area and proposes ecological protection and restoration strategies for the territorial space ecological source restoration area, ecological corridor restoration area, and stepping stone restoration area. The results showed that: (1) Human activities in the Guangdong-Hong Kong-Macao Greater Bay Area had high interference intensities and a wide impact on the ecological environment; areas with high and relatively high interference accounted for 48.65% of the total area, mainly concentrated in the central part of the Greater Bay Area. (2) The ecological network of Guangdong-Hong Kong-Macao Greater Bay Area presented a relatively stable characteristic pattern of "2 breadth lines and 4 length lines". The 2-breadth lines included the continuous mountains in the north and the ecological protection belt of the southern coastal waters. The 4-length lines included the eastern and western land corridors and the central water corridors. (3) The ecological source restoration area of the Guangdong-Hong Kong-Macao Greater Bay Area was 4,687.42 km2, the ecological corridor restoration length was 1,362.71 km, and the stepping stone restoration area was 833.82 km2, mainly distributed in Zhaoqing, Huizhou, and Jiangmen. To limit human disturbance and restore ecological functions, strategies for territorial space ecological restoration were proposed based on the ecological network function and structural integrity; (4) It is urgent for government departments to overcome the concept of regionalism and build a consensus on the co-disposal of ecological restoration in the territorial space. The construction of cross-domain collaborative governance institutions will efficiently promote the ecological restoration of cross-regional territorial spaces. Considering both human and ecological systems, this study discussed the ecological restoration schema in key areas of ecological networks, coastal ecological restoration areas, and trans-regional ecological restoration areas. The method for urban agglomeration territorial space ecological restoration was formed, including "ecological network pattern-human activity disturbance-restoration area diagnosis-restoration strategy," which will provide a framework for promoting the territorial space ecological protection and restoration in the Guangdong-Hong Kong-Macao Greater Bay Area.

Since the 21st century, the term "scene" has been widely used in various fields, mainly involving sociology, communication, education, the Internet, commercial marketing and so on. Academic circles have also carried out scene-related research to form their own definitions and theories. With the continuous innovation of technical means, the connotation of a scene is constantly enriched, from the face-to-face physical space dimension to the multi-dimensional information space, and gradually evolved into the scene characteristics of spatio-temporal integration. However, there is still a lack of complete theoretical research and practical discussion on what is the scene, what are the elements of the scene, and how to combine the specific scene to guide and carry out the scene planning and design in different fields. The existing scene theory cannot be well applied in the field of urban development, and cannot help the scene related research of coordinated development of urban agglomeration. By combing the development context of scene theory at home and abroad, this study makes an in-depth interpretation and analysis of the connotation and characteristics of the scene. It is believed that the scene contains six characteristic elements, such as time, space, object, problem, path and value. The scene is a kind of specific interactive relationship formed by a series of actions, based on the key issues and objectives of the events under specific spatio-temporal conditions, with technology and resources as the media. The construction of the scene can meet the needs of stakeholders and create and realize value. The theoretical system of scene planning including scene elements, scene hierarchy characteristics and scene planning methods is constructed. It is considered that scene planning is a systematic process to realize specific social, economic or ecological functions and values by integrating existing resources and technologies to carry out scene construction and design, focusing on key issues and objectives with stakeholders as its center, under the environmental factors of social and economic development, government policies and technological innovation. From the perspectives of scene recognition, scene construction, scene evaluation and scene application, the new exploration of scene planning tools is realized to guide scene practice in different fields. Taking the coordinated development of urban agglomeration in the Guangdong-Hong Kong-Macao Greater Bay Area as an example, this study excavates the current problems and development objectives of the Greater Bay Area based on the scene planning method, identifies 100 important scene units representing the coordinated development direction of urban agglomeration in the Greater Bay Area, and identifies and analyzes each scene element for these scene units, so as to provide basic support for further scene construction. Finally, taking the ecological corridor construction of urban agglomeration in the Guangdong-Hong Kong-Macao Greater Bay Area as an application example, the scene planning method is preliminarily applied to analyze the scene elements, so as to provide a basis for the next practical exploration work such as scene evaluation and scene application demonstration. The theoretical system of scene planning is not only a further extension of the scene concept, but also an overall coordination tool to promote the coordinated development of urban agglomeration. It can provide theoretical basis and practical guidance for the future scene research on the coordinated development of urban agglomeration, and help the collaborative construction of urban agglomeration. In the future, it is suggested to carry out specific scene analysis and scene design on the industry, population, transportation, environment, infrastructure and public services of the GBA urban agglomeration, and gradually realize the in-depth exploration of the coordinated development theory and mechanism innovation of the Guangdong-Hong Kong-Macao Greater Bay Area through the scene planning theory.

With an aim of maximizing the efficiency of edge offloading and the resource utilization of edge computing server simultaneously, a new flow-of-traffic prediction based edge computing offloading solution was proposed for Internet of vehicles (IoV).Firstly, both the efficiency utility function of vehicle and the resource utilization of mobile edge computing (MEC) server were established by considering task priority.Next, the formulated dual-objective optimization problem was transformed into a double auction problem between vehicles and MEC servers.Finally, based on the designed flow-of-traffic based pricing function of vehicle and MEC server, a McAfee auction algorithm was adopted to complete the edge computing process.Simulation results show that benefiting from the flow-of-traffic prediction information, the proposed solution can significantly improve both the efficiency of computation offloading and the utilization of computation resource.

Objective At present, the structural system of prefabricated underground stations in China presents diversified development characteristics, but lacks systematic classification. Therefore, the research progress on the structural performance of open-cut prefabricated underground stations is sorted out. Method Aiming at the current mainstream structure forms, the structural system characteristics of open-cut prefabricated underground stations are systematically summarized. The research on the structural performance of the above stations is organized from prefabricated elements, joint connections and overall structure three levels. The development direction of open-cut prefabricated underground stations is proposed. Result & Conclusion The structure of open-cut prefabricated underground stations can be classified into two categories: prefabricated-monolithic type and fully-assembled type. The research on prefabricated components of assembled underground station mainly focuses on the bearing performance of assembled plate components. The joint connection of prefabricated components is related to the bearing and seismic performance of the overall structure for the prefabricated underground station, and therefore is the focus of the research. The bearing and seismic performance of prefabricated underground structures is mainly investigated by numerical methods, and lacks experimental data on the overall structure. Studies on the load bearing performance of the above station considering the whole life cycle will become an important research direction.

Interplanetary meteoroids and space debris can impact satellites orbiting the Earth or spacecraft traveling to the Moon. Targeting China Space Station (CSS), 7 satellites selected from the constellation of Beidou Navigation Satellite System Phase III (BDS-3), and 3 spacecraft orbiting the Moon, we have adopted in the paper the Meteoroid Engineering Model 3, Divine-Staubach meteoroid environment model, and Jenniskens-McBride meteoroid steam model to analyze the meteoroid environment with the mass range of 10–6~10 g. Orbital Debris Engineering Model 3.1 space debris model is used to analyze the orbital debris environment faced by these satellites. The flux of space debris with a size larger than 100 μm is compared with that of the meteoroids. The results show that the space debris flux encountered by China Space Station is much higher than that of the meteoroids with sizes in the above range. And quite the opposite, the meteoroids flux impacting the 7 satellites from the BDS-3 is higher. Upon adopting the double-layer Whipple protection measure, the catastrophic collision flux of these satellites encountering meteoroids is about 10–6 times of that without protection, or even less, implying that the Whipple protection effectively guarantees the safety of the satellites in orbit. Besides, it is also found that the flux of the high-density meteoroid population encountered by each satellite is greater than that of the low-density population, whereas the impact velocity is lower for each satellite. These results can aid the orbit selection and the protection design for satellites and spacecraft.

Objective To observe the clinical effects of scraping on hypertensive ischemic stroke based on the theory of " Qi Circulation " . Methods Totally Sixty patients with hypertensive ischemic stroke who met the inclusion criteria were randomly divided into observation group and control group, with 30 patients in each group. All patients received conventional drugs and rehabilitation nursing, and patients in the observation group were treated with a 30-45 minutes of meridian scraping treatment based on "Qi Circulation " theory, once a week for 4 weeks. The changes of blood pressure, homocysteine (Hcy), matrix metalloproteinase-9(MMP-9) and blood lipid indexes including total cholesterol (TC), triglyceride (TG), high-density lipoproteincholesterol(HDL-C) and low-density lipoproteincholesterol(LDL-C) before and after intervention were compared between the two groups. Results Level of blood pressure, Hcy, TC, TG and LDL-C in 2 groups were decreased after intervention (P＜0. 05), better improvement was reported in the observation group than that in the control group (P＜0. 05). Conclusion Scraping based on the theory of "Qi Circulation" can effectively reduce blood pressure, Hcy, MMP-9, TC, TG, LDL-C levels in patients with prehypertensive ischemic stroke, and can be promoted and applied as a safe and effective adjuvant therapy. (目的 观察基于“一气周流”理论刮痧干预高血压缺血性脑卒中的临床疗效。方法 将符合纳入标准的60例高血压缺血性脑卒中患者随机分为观察组和对照组, 各30例。对照组给予常规药物及康复护理对症支持治疗; 观察组在对照组基础上基于“一气周流”理论, 选择相应经络刮痧, 每次45～60min, 每周1次, 两组疗程均4周。比较两组患者干预前后血压、同型半胱氨酸(Hcy)、基质金属蛋白酶-9(MMP-9)和血脂［总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)］变化情况。结果 两组患者血压、Hcy、TC、TG、LDL-C均较干预前降低, 差异有统计学意义(P

Background Dyslipidemia has become one of the global public health issues. However, the relationship between air pollution and dyslipidemia has been rarely reported. Objective To explore the relationship between air pollutant exposure and dyslipidemia in middle-aged and elderly people in mining areas. Methods A total of 1 965 residents over 45 years old were sampled using cluster random sampling from mining areas in western Hunan from 2018 to 2019. The general data and lipid indices were obtained by using an interviewer-administered questionnaire survey, a physical examination and a laboratory test. The level of air pollution of the mining area was calculated by inverse distance weighted interpolation, and the average daily dose (ADDtotal) of air pollutants of each resident was calculated, and used to divide them into Q1 group (0.5-0.7 m3·kg-1·d-1, n=172), Q2 group (>0.7-0.9 m3·kg-1·d-1, n=870), Q3 group (>0.9-1.1 m3·kg-1·d-1, n=717), and Q4 group (>1.1 m3·kg-1·d-1, n=172). Unconditional Logistic regression was used to analyze the relationship between ADDtotal and dyslipidemia. Results The annual average concentration of PM2.5 in the two mining areas exceeded the National Air Quality Standard (Ⅱ). The prevalence rate of dyslipidemia was 25.3% (498/1 965). There were statistically significant differences in mean age and body mass index (BMI), prevalence of smoking and hypertension between patients with normal and dyslipidemia (P

In recent years, skin tissue engineering technology has provided new treatment ideas for large-area wound repair. Skin tissue regeneration is mainly based on the use of appropriate tissue scaffolds. There are several types of scaffolds, such as porous, fibrous, microsphere, hydrogel, and acellular scaffolds. Scaffold materials include natural materials and synthetic materials, but either type of single material has its own limitations. At present, most scaffolds are composed of two or more materials to form composites. Therefore an important direction of skin tissue engineering research in the future involves deeply understanding the properties, advantages and disadvantages of the various biomaterials and scaffolds currently used and exploring the construction of biomaterials and scaffolds with better performance. This article reviews the research progress and application value of different tissue scaffolds and scaffold materials in skin tissue engineering, in order to provide reference for clinical application and research and development in the field of wound repair.

The optimization of capacity allocation of traditional microgrid has limited effect on improving economic efficiency. To solve this problem, a microgrid model based on the coupling of landfill gas power generation (LGPG) and power to gas (P2G) is propoed to improve economic efficiency. Considering the influence of carbon trading and the time value of capital on the optimal allocation of capacity, the full life cycle theory and net present value analysis method in economics are introduced. Then the mutation particle swarm optimization algorithm is used to obtain the optimal allocation of capacity in four scenarios for maximizing the benefit of the whole life cycle. The optimal operation scheme is obtained by Cplex under the optimal allocation of capacity of the traditional microgrid model and the proposed microgrid model. The simulation results show that the economic efficiency of proposed microgrid model based on LGPG-P2G is higher than that of tranditionl microgrid model under the background of carbon trading.

This paper reviewed the clinical data of a patient with postherpetic neuralgia, summarized the intervention effect of five-element music therapy and acupoint massage and related nursing measures. Five-element music theory was conducted under the guidance of traditional Chinese medicine, combined with manipulation massage on selected acupoints. Comprehensive nursing interventions such as dietary guidance and emotional care were carried out to improve treatment efficacy of pain relief in patients with postherpetic neuralgia. (本文总结1例五行音乐联合穴位按摩治疗带状疱疹后遗神经痛(PHN)患者的护理经验, 通过辨证施乐, 给予患者聆听音乐, 并选取相关穴位进行手法按摩, 同时配合饮食护理、情志护理等综合干预措施, 有效改善PHN患者疼痛症状。)

Aiming at the mutation in demodulation of the envelope estimation function, a local mean decomposition method for singular interval envelope reconstruction is proposed. This method determines that the reason for the sudden change in the demodulation of the envelope estimation function is the intersection of the envelopes, and defines the local area where the intersection exists as a singular interval. Combined with the extreme value symmetry theory, the interpolation points in this interval are expanded, and the cubic Hermitian interpolation is used to perform local reconstruction. A singular interval envelope reconstruction algorithm is formed. The simulation signal and the application of fault diagnosis of reciprocating compressor bearing prove that the proposed method solves the envelope crossing problem, suppresses the demodulation mutation phenomenon, and the decomposition result has more obvious fault characteristics.

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Objective: To study the physical and geometric factors that affect the extrusion effect between particles in the spiral extrusion dewatering device for kitchen waste, and to provide reference for selecting the parameters of the spiral extrusion and dewatering device. Methods: Based on the discrete element method, the state of the extruded particles was analyzed, and the extrusion situation of the material particles in the device was simulated by changing the filling coefficient, spiral speed and inclination angle. Results: When there was some inclination angle in the screw extrusion dehydration device with variable pitch, the filling coefficient increased and the rotation speed up, and the extrusion pressure between the material particles increased accordingly. Conclusion: When the filling rate was 60%, the screw speed was 60 r/min, and the angle was 15°, the extrusion performance of the screw extrusion device could be significantly improved.

Objective To investigate the infection features of high-risk human papillomavirus (HR-HPV) and screening characteristics of HR-HPV-negative cases in patients with cervical high-grade squamous intraepithelial lesion (HSIL). Methods A retrospective analysis was conducted on the screening results of 459 patients who were pathologically diagnosed as cervical HSIL in our hospital from January 2019 to August 2020. The positive detection rates of HR-HPV test, thinprep cytologic test (TCT), and their joint screening were compared among the patients, and the analysis of key points to avoid missed diagnosis were conducted in HR-HPV negative cases. Results Among the 459 HSIL patients, the single subtype infection accounted for 71.90% (330 cases), multiple infection 22.22% (102 cases); the positive rate of HR-HPV was 91.94% (422 cases), and the monotype infection with the highest positive rate was HPV subtype 16 (45.76%). The positive detection rates of the 3 tests were 77.34%, 64.27% and 82.79% respectively, with significant difference (P < 0.01). Moreover, 25 cases (67.57%) in the HR-HPV negative group had worse than ASCUS results of TCT, while 3 cases (8.11%) with ASCUS and 9 cases (24.32%) with negative TCT results were referred to colposcopy due to clinical symptoms, and 6 HR-HPV negative cases with normal colposcopy showed abnormal TCT results. Conclusion HR-HPV infection and monotype infection are predominant in cervical HSIL patients. The combined screening of HR-HPV and TCT has the highest positive diagnostic rate, while the HR-HPV negative patients usually have obvious clinical symptoms and TCT abnormalities.

This review summarized the research status of NADES on the extraction and separation of phenols, discussed the main factors affecting the extraction efficiency, and prospected the future development direction.

Intensive agriculture is the way for production and management in modern agriculture, which increases the yield per unit area of farmland, brings a series of environmental and ecological problems, and limits the sustainability of agriculture. Landscape preference focuses on different stakeholders' preferences for landscape, reflects the influences of human's subjective feelings and behaviors on landscape. Based on the agricultural landscape of Fengqiu County in Henan Province, we investigated the characteristics of the landscape elements which stakeholders preferred and analyzed the reasons using the questionnaire survey and other related methods. We proposed several suggestions for future development of the agricultural landscape in study area. The results showed that stakeholders preferred the landscape element which is simple and easy to manage, and emphasized the production and economic functions of agricultural landscape. Experts and local environmentalists preferred the landscape elements with multiple functions and benefits, as well as complex landscape configurations with high heterogeneity, with the aim to develop the multifunctional agricultural landscape. Factors such as education level, professional background and types of intervie-wees had obvious influences on the landscape preference of stakeholders. The decision-making beha-vior of government, the degree of economic compensation, and the technological support of eco-agriculture would be the important factors determining the possible development of landscape structure and function in the future. [ABSTRACT FROM AUTHOR]

Objective To evaluate the safety and efficacy of carbon ion and proton therapies for pancreatic cancer (PaC). Methods The databases were electronically searched to collect the studies about the carbon ion and proton therapies for PaC from inception to June 2019. Two reviewers independently screened literature and extracted data. A Meta-analysis was performed by STATA 12.0 and MetaAnalyst Beta 3.13 software. Results A total of 8 studies involving 459 PaC patients were included. The incidence of grade 2, 3 and 5 gastrointestinal (GI) ulcer toxicities in PaC patients treated with carbon ion and proton therapies were 7%, 2% and 0; the incidence of grade 2, 3 and 4 anorexia toxicities were 6%, 3.2% and 0; the 1- and 2-year OS rates were 77% and 45%; the 2-year local control (LC), 1-year freedom from local progression (FFLP) and 1-year local recurrence(LR) rates were 81%, 88% and 15%. The incidence of grade 2, 3, 2-3 GI ulcer toxicities in carbon ion and proton therapies for PaC were 6.8%, 1.5%, 9.2% and 3.5%, 8.3%, 6.1% (P < 0.05); and the 1- and 2-year OS were 77.1%, 44.4% and 77.6%, 49.7% (P > 0.05). Conclusion Carbon ion and proton therapies for PaC are safe and effective; and the security and effectiveness of the two methods are similar.

To investigate the effect of long-term fertilization on lignin accumulation and clarify its influencing factors in subtropical agricultural upland soils, alkaline CuO oxidation and gas chromatography was performed to quantify the amount of lignin and its monomers components (V, S and C). The soil samples were collected from the fertilization treatments of NPK and NPKS (NPK combined with straw) in Huanjiang County, Guangxi Province (limestone soil) and Taoyuan County, Hunan Province (red soil). The results showed that NPK had no significant effect on the lignin content (SumVSC) of limestone soil, whereas the content in red soil significantly increased by (55±1)%. For the NPKS treatment, the lignin content in limestone and red soil increased by (328±4)% and (456±9)%, respectively. After the same fertilization treatment, the proportion of cinnamyl (C)-type significantly increased in red soil, while a significant increase of vanillyl (V)-type monomers occurred in limestone soil, indicating that lignin degradation in agricultural soils was monomer specific. Furthermore, the acid-to-aldehyde ratios of syringyl-type [(Ac/Al)S] or vanillyl-type [(Ac/Al)V] monomers tended to decrease after long-term fertilization with the higher value for limestone soil, suggesting the degree of lignin degradation in limestone was higher than that in red soil. Soil organic matter and total nitrogen were not correlated with lignin content, but were significantly correlated with the composition of VSC monomers. Meanwhile, the available nutrient content in the soil (available nitrogen, phosphorus, and potassium) was closely related to the contents and components of V, S, and C-type monomers (P<0.05). It indicated that the availability of soil nutrition should be considered as a key factor for the accumulation of lignin. [ABSTRACT FROM AUTHOR]

The article presents a study that evaluates the molecular characterization of Escherichia coli isolated from dogs wherein the results show that the isolates from diseased dogs were resistant to more antibiotics than those from healthy dogs.

The article focuses on a study which examines Brucella melitensis rough vaccine strain M111 ghosts' preparation and characterization.

In view of problems of poor extensibility, single communication mode and difficult locating of fault point existed in current miner's lamp charging monitoring and management system, an intelligent miner's lamp charging monitoring and management system was designed. In the system, charging unit collects miner's lamp condition in real-time, control unit receives the collected data through RS485 bus and transmits it to CAN/Ethernet module through CAN bus, server receives the data through Ethernet,monitoring software displays charging condition according to the data uploaded by the server and sends miner's information to the charging unit. The test results show that the system can accurately collectminer's lamp condition and realize real-time miner's lamp monitoring and miner's information management.

The article discusses a study on expression and activity of New Delhi metal-ß-lactamase-1 based on culture temperature, inducing time and Isopropyl ß-D-1-thiogalactopyranoside concentration to study expression conditions of recombinant protein. It states that protein was identified by matrix-assisted laser desorption-ionization (MALDI-TOF-MS) and ethylenediaminetetraacetic acid (EDTA) has an inhibitory effect on fusion protein enzymatic activity in vitro.

Transport route optimization of dangerous goods makes lower transportation risk and cost of the enterprise, meanwhile it provides basis reference for the government decision. On the basis of urban master planning, the characteristics of transport of dangerous goods was analyzed, and then the index system on transport of dangerous goods was established. In order to implement this research and quantify the indicators, road characteristics and nature of land along the section has been used to evaluate the risk, simultaneously, the emergency response capacity was considered as the correction factor to improve the risk model, and the BPR impedance function was applied to calculate the transportation costs, then the calculation process of transportation risk and costs was given with an example of Pingxiang, Jiangxi. On this basis, a bi-objective optimization model was created with the target of risk and cost, and method of solving the model was discussed. This model provides a theoretical basis for the transport network of dangerous goods planning and design for its simplicity, practicality and operability. [ABSTRACT FROM AUTHOR]

As one of the key enzymes involved in lignin decomposition of forest litter, laccase plays an important role in the carbon cycling in forest ecosystem. By using TA cloning and sequencing, a comparative study was conducted on the basidiomycetous laccase gene diversity in the O horizon (litter layer) and A horizon (surface soil layer, 0 - 2 0 cm) in two subtropical forests ( a primeval evergreen deciduous broadleaved mixed forest and an artificial masson pine forest). For the same soil horizons, the basidiomycetous laccase gene diversity and richness were higher in the primeval forest than in the masson pine forest; for the same forest ecosystems, the basidiomycetous laccase gene diversity and richness in the primeval forest were slightly higher in O horizon than in A horizon , but those in the masson pine forest were apparently lower in O horizon than in A horizon. The two forest soils had the same dominant laccase gene-containing basidiomycetous populations, and most of the populations had high similarity of amino acid sequence to Mycena sp. or Pleurotus sp. belonging to Agaricales. Comparing with the A horizon in primeval forest and the O horizon in masson pine forest, the O horizon in primeval forest and the A horizon in masson pine forest had a relatively uniform distribution of basidiomycetous populations. The nucleotide sequence similarity of basidiomycetous laccase gene between the O and A horizons in the masson pine forest was higher than that in the primeval forest. This study showed that vegetation and soil horizon had significant effects on the basidiomycetous laccase gene diversity and community structure, and the discrepancies in the substrate availability for basidiomycetes and in the soil pH induced by the vegetation and soil horizon could be the driving forces. [ABSTRACT FROM AUTHOR]

Uncontrolled intersection vehicle delay is of great significance for evaluating the intersection service level, so that it is necessary to study a relative practical delay calculation method. This paper analyzes vehicles operating characteristic; divides the vehicle delay into waiting delay and acceleration-deceleration delay; uses probability theory to derive an iterative method which includes the average service time and service time variance of every approach ; describes the queue phenomenon of uncontrolled intersection with M/G/I queuing system; proposes the average waiting delay formula; and puts forward the acceleration-deceleration delay of uncontrolled intersection by using the method of signal intersection for reference. It is showed that the theoretically calculated values are close to observed values of delay that come from an uncontrolled intersection of shizi street and xuan-wei street in Harbin. [ABSTRACT FROM AUTHOR]

Trip production forecast is one of key components of traffic demand analysis, which directly determines the scale and layout of different urban traffic facilities. The mechanism of artificial neural network (ANN) and influential factors of trip production were analyzed, therefore, a four-layer back-propagation neural network ( BP neural network) model was set up to forecast the trip production, in which the input neurons are land-uses of different traffic zones and the output is trip production. Meanwhile, the model was calibrated and testified with traffic survey data from the urban integrative transportation planning of Ganzhou city. Furthermore, the results were compared with those obtained from trip production rate method and multiple linear regression method, It is showed that forecast precision of the BP neural network is relatively high. [ABSTRACT FROM AUTHOR]

As the problem of tramp children becomes in the limelight, the needs and growth of the tramp children have aroused the public concern. At present, the traditional social aid mode is of little avail in practice. The introduction of social work has brought new methods and perspectives in solving the problem, promoting the aid work of tramp children in a humanitarian, specialized way. [ABSTRACT FROM AUTHOR]

In order to make the crosswalk serve cross-street pedestrian better and do not influence the vehicles greatly, setting conditions and the location of uncontrolled crosswalk on road section were studied. The law of pedestrians and vehicles moving on the road with or without the setting of uncontrolled crosswalk was analyzed, and two methods of calculating total traffic expenses under above two conditions were proposed. The comparison shows that the setting of uncontrolled crosswalk should obey the maximal traffic benefit. Then an optimal location model for uncontrolled crosswalk sitting was established on the basis of the minimal total expenses, the enumeration method and inherit algorithm were used to optimize the location, and example verification was given. This study can be used to guide the setting of uncontrolled crosswalk on road section and optimize the pedestrian crossing environment. [ABSTRACT FROM AUTHOR]

The article presents a study which examines the adherence of enterohemorrhagic Escherichia coli (EHEC) O157:H7 mutants to human epidermoid cancer (HEp-2) cells. Researchers develop a LEE-encoded regulator (LER) deletion mutant of O157:H7 by the use of a suicide vector pCVD442, and analyze the mutant's attachments to HEP-2 cell by the utilization of polymerase chain reaction (PCR). Results show the importance of LER gene to the capability of the mutant to attach to HEp-2 cells.

Taking sweeping robot as the research object,solving the requirement of climbing higher steps and automatically adapting to different step heights in the process of robot running. An adaptive auxiliary obstacle climbing mechanism is designed,which is connected with the main driving wheel of the machine and is triggered by connecting rod mechanism when the step is touched to increase the additional driving force. The whole process of obstacle crossing is modeled by Euler dynamic equation. Combined with the application of the product in the actual family environment,the formula for calculating the torque of the key design parameters is given after excluding the distracters. Finally,the practical data of the mainstream products in the market are calculated,and the feasibility and application value of the auxiliary mechanism on the specific products are verified.

Hydrosalpinx with a high incidence in women of child-bearing age not only damages their fertility, but also has an obvious adverse effect on the outcomes of IVF-ET. it is always a problem how to handle properly hydrosalpinx before IVF-ET,even there is not a international guideline for standard treatment. There are several classical methods including transvaginal hydrosalpinx aspiration, salpingectomy, proximal tubal ligation, distal salpingostomy and fallopian tube proximal end occlusion. Based on recent publications on the pretreatment protocols of hydrosalpinx before IVF-ET,the advantages and disadvantages of those protocols were reviewed in this paper, while the hysteroscopic fallopian tube proximal end occlusion was especially evaluated, including its feasibility and safety. This therapy has recently been proved to be efficient. It is inconclusive which of the current pretreatment protocols for hydrosalpinx to be better. Hysteroscopic fallopian tube proximal end occlusion, as a new method with advantages of wider indications, effeciency, mild invasion, simple and economic method, is worthy of being recommended in clinical application. [ABSTRACT FROM AUTHOR]

The high-concentration of methane accumulating in a tilted roadway could produce gas flow pressure.This gas flow pressure can induce airflow disorder in the tilted roadway and its lateral roadways.In this paper, an experimental system was constructed for representing parallel downward ventilation roadways.With this system, a series of experiments were conducted to study the gas flow pressure-induced airflow disorder in coal mine roadways.The tilted roadway was saturated with 100% concentration methane while the lateral roadway was saturated with air for all experiments.The resistance coefficient of the tilted roadway and the lateral roadway were changed in different experiments.The experimental results indicate that the gas flow pressure could cause complex airflow changes in parallel downward ventilation roadways and lead to methane and airflow reciprocation in the roadways.A vibration model was developed based on a simplification of the experimental system.The vibration model can explain the effects of windage on the damping force of the vibration.Both the experiment and model results indicate that the windage increase of the tilted roadway or the lateral roadway can weaken the airflow vibration.Analysis of the methane movement in the experimental system indicates that for the tilted roadway and the lateral roadway an windage increase in one roadway is helpful for the airflow stability but harmful for its own gas discharge.If gas accumulation appears in an in situ downward ventilation roadway, the windage of the lateral roadway should be increased without delay to keep the system airflow stable and to discharge the accumulated methane as soon as possible.

The traditional reliability evaluation is based on the failure data,which needs a large amount of statistical data and samples,and comprises the characteristics of long test cycle and high cost. To solve this problem,without failure data,a method of reliability evaluation was proposed which was based on the performance degradation data. The performance degradation model was built in the method which was based on the least square support machine. With the help of NSGA-II,the parameters optimization of the method above had been done,and the process of parameters optimization and reliability evaluation was given.Last but not least,the availability of the method is validated.

A seeker optical system of non-spherical dome with large fineness ratio is purposed in this paper. Properties of the aberration and its correction methods are analyzed and discussed. The designed dome optical system has the following features: fineness ratio is 2, operating waveband is the middle infrared spectrum, half of the field is 30 degrees, and its F number is 2. The results show that the image quality is approaching the diffraction limit and satisfies the requirements of imaging optical system. [ABSTRACT FROM AUTHOR]

Abstract: Along with China′s economic development, the dissolution of heavy metals in port minerals stockyard has became important contamination sources of soil and water, which can't be ignored. The amount of heavy metal dissolution is related to the species of heavy metals. Through the static soaking test, according to the leaching of heavy metals to determine the typical mineral products and the typical heavy metal factor to study the influence of time, pH and temperature on release of heavy metals in typical products at Tianjin port stockyard. The results showed that the amounts of heavy metals released from lead ore and copper ore were the greatest. Zn, Pb and Cd in the lead ore and Ni in the copper ore were the typical heavy metal factor, and were found to be 1-3 orders of magnitude higher than other heavy metal ions. The concentration of Zn, Pb, and Cd in lead ore increased with time, and the concentration of Ni in the copper ore basically remained stable. The concentration of Zn, Pb and Cd in the lead ore and Ni in the copper ore had no significant differences with the change of pH (3.5 to 7.5). The concentration of Zn, Pb, and Cd in the lead ore increased with temperature (20-40℃). The concentration of Ni in the copper ore showed a downward trend above 30℃. This study preliminarily investigated the basic rule of dissolution of heavy metals in minerals and provides data to support and control the dissolution of heavy metals in the port stockyard.

本研究目的是探討透過使用本研究所設計的地理桌遊牌卡遊戲融入世界地理課程時，遊戲中學生的遊戲自我效能、遊戲興趣、認知負荷與地理桌遊的遊玩自信心提升之相關性為何。為達本研究目的，本研究從新北市國中蒐集 149 份有效資料，經由信度及效度檢驗後，使用VirtualPLS 統計軟體進行研究模型驗證。研究結果顯示：在地理桌遊活動的情境中，遊戲自我效能對於遊戲興趣呈現正影響，遊戲自我效能與認知負荷呈現負影響；最後，遊戲興趣能有 效地幫助地理桌遊的遊玩自信心提升，而認知負荷則會負向影響地理桌遊的遊玩自信心提升。由此可見，牌卡桌遊活動是可以融入地理課程的一種良好教學方式，如果學習內容設計得宜，透過玩中學的過程中，讓學習者獲得知識並進行複習。 This study explored the integration of geography board games into a world geography curriculum. Through this game, students’ gameplay self-efficacy, gameplay interest, cognitive load, and self-confidence were evaluated. This study collected 149 valid data to test the reliability and validity, and VirtualPLS statistical software was employed. The study results demonstrated that in the context of geography board games, gameplay self-efficacy were positively correlated with gameplay interest and negatively correlated with cognitive load. Additionally, gameplay interest in geography board games was found to effectively improve self-confidence. The study results indicate that well-designed learning content enables learners’ knowledge gains and gives them the chance to review the content during the process of playing.

Objective To explore the role of student research training program(SRTP) in improving the scientific research interest, basic knowledge and basic ability of undergraduate-master's consecutive medical students. Methods A questionnaire survey was conducted among 69 medical students who were in the 2015 and 2016 clinical programs. They participated in and completed SRTP. And some situations was statistic analysis including students' SRTP team formation, project implementation, satisfaction, and academic results(published papers). Results 85% of the project direction was to be completed independently by the project team members under the guidance of the mentor.The comprehensive scientific research ability of students at the later stage of the project was obviously higher than the beginning of the project.More than 85% of students were satisfied with the completion of the SRTP course. SRTP had a significant improvement in students' scientific research thinking, communication and collaboration ability, experimental habits, and learning ability. There were shortcomings such as low student publications and low quality. Conclusions SRTP can be used as a pre-cultivation link for the improvement of scientific research ability of undergraduate-master's consecutive medical students. It plays a bridge role of scientific research ability in continuous cultivation of undergraduate-master degree, and which has important reference value for talent training in medical universities.

Objectives: To develop effective measures to reduce antibiotic use duration in very low birth weight (VLBW) preterm infants in the neonatal intensive care unit through quality improvement methods., Methods: The study population consisted of hospitalized VLBW preterm infants, with the percentage of hospitalization time during which antibiotics were used from November 2020 to June 2021 serving as the baseline. The specific quality improvement goal was to reduce the duration of antibiotic use. Factors affecting antibiotic use duration in preterm infants were analyzed using Pareto charts. Key drivers were identified, and specific interventions were formulated based on the stages of antibiotic use. Changes in the percentage of antibiotic use duration were monitored with run charts until the quality improvement target was achieved., Results: From November 2020 to June 2021, the baseline antibiotic use duration percentage was 49%, with a quality improvement target to reduce this by 10% within 12 months. The Pareto analysis indicated that major factors influencing antibiotic duration included non-standard antibiotic use; delayed cessation of antibiotics when no infection evidence was present; prolonged central venous catheter placement; insufficient application of kangaroo care; and delayed progress in enteral nutrition. The interventions implemented included: (1) establishing sepsis evaluation and management standards; (2) educating medical staff on the rational use of antibiotics for preterm infants; (3) supervising the enforcement of antibiotic use standards during ward rounds; (4) for those without clear signs of infection and with negative blood cultures, discontinued the use of antibiotics 36 hours after initiation; (5) reducing the duration of central venous catheterization and parenteral nutrition to lower the risk of infection in preterm infants. The control chart showed that with continuous implementation of interventions, the percentage of antibiotic use duration was reduced from 49% to 32%, a statistically significant decrease., Conclusions: The application of quality improvement tools based on statistical principles and process control may significantly reduce the antibiotic use duration in VLBW preterm infants. Citation:Chinese Journal of Contemporary Pediatrics, 2024, 26(7): 736-742 .

Moringa oleifera leaves are known for their &quot;Virechana&quot;(purgative) effect in Ayurvedic medicine in India. This study compared the purgative effects and mechanisms of M. oleifera leaves with the reference Rhei Radix et Rhizoma to establish a foundation for the further application of M. oleifera leaves in traditional Chinese medicine(TCM). Using network pharmacology and molecular docking methods, this study identified the material basis, common targets, and signaling pathways through which Rhei Radix et Rhizoma and M. oleifera leaves exerted their purgative pharmacological effects. A low-fiber diet-induced constipation mouse model was established to measure fecal parameters and small intestinal propulsion rate, and histological changes in the colon were observed using HE staining. Relative expression levels of relevant genes and target proteins were assessed using RT-qPCR and immunohistochemistry, respectively. The results showed that mapping the targets of Rhei Radix et Rhizoma and M. oleifera leaves onto the biological process network of constipation revealed close proximity, indicating that they may exert their therapeutic effects on constipation through similar biological processes. Molecular docking results indicated that compounds such as sennoside C and isoquercitrin could target serine/threonine protein kinases(AKT1) and mitogen-activated protein kinase 3(MAPK3), thereby affecting MAPK and calcium signaling pathways to promote defecation. Animal experiments demonstrated that both M. oleifera leaves and Rhei Radix et Rhizoma increased the number of fecal pellets and water content in constipated mice, improved small intestine motility, colon mucosal thickness, and muscle layer thickness, upregulated the gene expression levels of AKT1 and MAPK3 in the colon, and downregulated the expression of AQP3 protein. These findings suggest that M. oleifera leaves and Rhei Radix et Rhizoma share similarities in their therapeutic efficacy and mechanisms for treating constipation. Using Rhei Radix et Rhizoma as a reference can provide a better understanding of the characteristics of the &quot;Virechana&quot;(purgative) effect of M. oleifera leaves in TCM.

The study investigated the chemical constituents from the whole herb of Carpesium cernuum. Three new diterpenoids were isolated from the whole herb of C. cernuum by column chromatography on silica gel, Sephadex LH-20, and semi-preparative HPLC. Their structures were identified by MS, NMR and other spectral techniques. The isolates were identified as(5Z)-2-oxo-2, 10, 14-trimethylhexadeca-5, 13-diene-11α, 18-diol(1),(2E, 10E)-7-[(acetyloxy)methyl]-3, 11, 15-trimethylhexadeca-2, 10, 14-triene-1, 12α-diol(2),(2E, 6Z)-3, 11, 15-trimethylhexadeca-2, 6, 14-triene-1, 12α, 19-triol(3), respectively. The cytotoxic activity of compounds 1-3 were investigated with DU-145, MCF-7, and A549 cells by MTT. The results showed that compound 1 and 3 had certain inhibitory effects on MCF-7 cells, with the inhibition rates of 45.06% and 29.40%, respectively.