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OBJECTIVE: Exercise intervention is one of the main treatments for fibromyalgia, but there is no consistent conclusion on the choice of different exercise modalities. In this article, a network Meta-analysis was used to comprehensively and quantitatively evaluate the effects of different exercise modalities on fibromyalgia syndrome. METHODS: PubMed, EMbase, Scoups, The Cochrane Library, Web of Science, CNKI, WanFang Database, and China Biomedical Literature Database were searched for relevant literature, with a search timeframe from the establishment of each database to June 2023. The outcome indicators included five continuous variables, including fibromyalgia impact questionnaire-revised (FIQ) scores, visual analogue scale (VAS) scores, quality of life, quality of sleep, and depression. The Cochrane Risk of Bias Assessment Tool was used to evaluate the quality of the included literature. RevMan 5.4 software was used to perform effect sizes, subgroup analyses, and sensitivity analyses of the data. Stata 17 software was used to perform reticulation and network Meta-analysis of the data. RESULTS: A total of 13 articles with 14 randomized controlled trials were finally included. The overall methodological quality of the literature was high. The results of traditional Meta-analysis showed that, compared with the control group, exercise therapy significantly improved the FIQ score [standardized mean difference (SMD)=-0.67, 95% confidence interval (CI): -0.83 to -0.50, P < 0.01], VAS score (SMD=-0.72, 95% CI:-0.90 to -0.54, P < 0.01), quality of life (SMD=1.03, 95% CI: 0.45 to 1.61, P=0.000 5), sleep quality (SMD=-0.62, 95% CI: -0.98 to -0.25, P=0.001), and depression (SMD=-0.63, 95% CI: -1.09 to -0.18, P=0.007). Network Meta-analysis showed that the probability of optimal intervention effect of exercise modalities on FIQ scores was ranked as: mind-body exercise (86.5) > resistance exercise (70.5) > aerobic exercise (41.7); the probability of optimal intervention effect of exercise modalities on VAS scores was ranked as: resistance exercise (85.3) > mind-body exercise (74.3) > aerobic exercise (34.5). CONCLUSION: Exercise therapy significantly improves FIQ scores, VAS scores, quality of life, sleep quality, and depression in patients with fibromyalgia syndrome. Mind-body exercise and resistance exercise are the most effective exercise modalities to reduce FIQ scores and VAS scores in patients with fibromyalgia syndrome. [ABSTRACT FROM AUTHOR]

AIM: To investigate the effects of exercise preconditioning （EP） combined with electroacupuncture（ EA） on learning and memory ability of rats with vascular dementia（ VD）, and to explore role of hippocampal ferroptosis in this process. METHODS: Seventy-two male SD rats were randomly divided into non-EP group and EP group, with 36 rats in each group. The rats were subjected to EP, and subsequently to establish the VD model. The rats from non-EP group were randomly divided into sham group, model group （VD group） and VD-EA group, each with 12 rats, while those in EP group were randomly divided into EP-sham group, EP-VD group and EP-VD-EA group, each with 12 rats. All rats in EP group underwent 4 weeks of swimming exercise training, 5 d per week, 30 min per day. At the end of the 4th week, the rats in VD, EP-VD, EP-VD-EA and VD-EA groups were used to induce the VD model, and the rats in sham and EP-sham groups received a sham surgery to simulate the VD model. On the 7th day after successful modeling, the rats in EP-VD-EA and VD-EA groups were treated with EA for 4 weeks, 6 d per week, 30 min per day. At the end of the intervention, the learning and memory ability of the rats was evaluated using Morris water maze. Neuron morphology in the CA1 area of rat hippocampus was observed through Nissl staining. Ferrous ion （Fe2+）, malondialdehyde （MDA） and reduced glutathione（ GSH） contents in the rat hippocampal tissues were quantified using the colorimetric assay. The expression levels of ferroptosis-related proteins, nuclear factor E2-related factor 2（ Nrf2） and glutathione peroxidase 4（ GPX4）, in the hippocampal tissues were quantified by Western blot method. RESULTS: Compared with sham group, the rats in VD group exhibited longer mean evasion latency and decreased number of traversals across the plateau （P<0. 01）. The neurons in the CA1 region of the hippocampus were loose and disorganized, exhibiting an irregular cellular morphology. The hippocampal Fe2+ and MDA content was elevated, and the GSH content was reduced （P<0. 01）. The protein levels of hippocampal Nrf2 and GPX4 were decreased （P<0. 01）. Compared with VD group, the rats in EP-VD, EP-VD-EA and VD-EA groups showed a shorter average escape latency and an increased number of traversals across the plateau （P< 0. 05）. Neurons in the hippocampal CA1 area were more neatly arranged, showing regular cellular morphology. The hippocampal Fe2+ and MDA contents of the rats in EP-VD group were significantly reduced（P<0. 01）, while the GSH content was elevated （P<0. 05）. Hippocampal Fe2+ and MDA contents were significantly reduced and GSH contents were significantly increased in EP-EA and EA groups （P<0. 01）. The protein levels of hippocampal Nrf2 and GPX4 in EP-VD, EPVD-EA and VD-EA groups were significantly increased （P<0. 01）. CONCLUSION: Exercise preconditioning combined with EA improves learning and memory ability in VD rats by reducing hippocampal intra-neuronal iron overload, maintaining organismal redox homeostasis, and inhibiting ferroptosis. [ABSTRACT FROM AUTHOR]

Objective To investigate the effect of individual exercise training on the rehabilitation of patients with coronary heart disease (CHD) after percutaneous coronary intervention (PCI). Methods A total of 81 patients between January 2021 and December 2023 were randomly allocated into an observation group (n = 41) and a control group (n = 40) using a simple random number Tab.method. The control group received routine post- operative rehabilitation intervention, while the observation group received individualized exercise training as the core component of cardiac rehabilitation intervention. The study compared the effects of rehabilitation, cardiac function parameters [left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD)], exercise endurance measures [6-minute walking distance (6MWD)], and quality of life assessed by Seattle Angina Pecina Scale (SAQ) scores between the two groups before and after a three-month intervention period. Results The total recovery response rate in the observation group was higher than that in the control group (P < 0.05). LVEF, LVEDD, 6 MWD, maximum exercise load and SAQ scales (P > 0.05), LVEF were higher than before intervention (t = 3.345, 2.480, 3.165, 5.016, 2.059, 4.582, 4.443, 3.353, P < 0.05), and LVEDD was lower than before intervention (t = 3.335, P < 0.05). Conclusion The individualized exercise training-based cardiac rehabilitation program demonstrates potential for enhancing cardiac function and exercise endurance in patients with CHD following PCI, thereby improving their overall quality of life. This finding holds significant clinical implications. [ABSTRACT FROM AUTHOR]

Background Anthracyclines are fundamental in the chemotherapy treatment of breast cancer, but these treatments often lead to changes in physique, such as increased body fat and decreased cardiopulmonary function, alongside gastrointestinal reactions and bone marrow suppression, thereby impacting the patients' quality of life. Current studies on the ameliorative effects of exercise on these side effects yield inconsistent results, necessitating further research. Clinically, the efficacy and safety of exercise prescriptions in mitigating these chemotherapy side effects in breast cancer patients warrant further exploration. Objective This study aims to investigate the effectiveness and safety of aerobic exercise in improving the physique and quality of life of breast cancer patients during anthracycline-based chemotherapy. Methods This study is a randomized controlled trial involving 44 adult female breast cancer patients who received anthracycline-based chemotherapy at Beijing Chaoyang Sanhuan Cancer Hospital, from March 2022 to January 2023. They were randomly assigned to an exercise group (23 participants) and a control group (21 participants). The control group was informed about personalized exercise guidance after chemotherapy. The exercise group, under the supervision of rehabilitation therapists, engaged in workouts during their hospital stay and continued personalized exercise interventions at home with self-monitoring and remote supervision by researchers. Key outcome measures, including physique and quality of life, were collected before and after chemotherapy, along with the incidence and severity of gastrointestinal reactions, bone marrow suppression, and exercise-related adverse events. Covariance analysis, using pre-chemotherapy data as covariates, compared the physique and quality of life between the two groups. Results Four participants were lost during the intervention and follow-up, leaving 40 participants (21 in the exercise group, 19 in the control group). No severe adverse events were observed during the exercise intervention. The average compliance with the exercise intervention was 81.8%; average compliance per exercise session was 91.9%, and average compliance with exercise intensity was 92.5%. Post-chemotherapy, the exercise group showed lower body fat weight, body fat percentage, visceral fat area, waist circumference, waist-to-hip ratio, and significantly higher grip strength of the dominant hand and relative peak oxygen uptake (VO2peak) compared to the control group (P

Background Telerehabilitation based on digital medical care can efficiently improve the health status of patients after radiofrequency ablation of atrial fibrillation. However, the current participation rate in telerehabilitation is low. Objective To analyse the reasons for refusal of exercise rehabilitation in patients after radiofrequency ablation of atrial fibrillation in the context digital medical care based on the theory of leisure constraints. Methods Patients after radiofrequency ablation of atrial fibrillation in the inpatient department or outpatient clinic of Department of Cardiology, at the First Affiliated Hospital of Nanjing Medical University from July to September 2022 were selected as the study subjects by using the purposive sampling method. The phenomenological approach was adopted to collect data from patients who refused exercise telerehabilitation after radiofrequency ablation through semi-structured interviews, and Colaizzi analysis was used to summarize the reasons. Results A total of 14 patients were finally included in this study. Three themes including self-limiting factors, interpersonal limiting factors, and structural limiting factors, and twelve sub-themes were extracted, namely, low level of digital literacy, negative illness perception, psychological distress caused by disease, digital medical trust crisis, deep-rooted personal exercise habits, alienation sense from rehabilitation team, insufficient social network establishment, economic burden related to equipment acquisition, harsh climate, low rehabilitation service capacity in primary care, constraints of available time by role pressure, and poor applicability of wearable devices. Conclusion The reasons for refusal to exercise telerehabilitation include lack of literacy and trust in digital medical care, high level of illness perception and psychological distress, poor exercise habits, rehabilitation team and peer alienation, economic burden, harsh climate, lack of capacity and personal time for rehabilitation service capacity in primary care, and inadequate applicability of existing wearable devices.

Objective To evaluate the efficacy of repetitive facilitative exercise combined with low-frequency acupoint electrical stimulation therapy in the recovery of patients with upper limb motor dysfunction after stroke. Methods Sixty-two patients with upper limb motor dysfunction after stroke were divided into the observation group (n = 31) and control group (n=31). Patients in the control group were treated with conventional rehabilitation training combined with low-frequency acupoint electrical stimulation in Department of Neurology, and those in the observation group were treated with repetitive facilitative exercise besides the interventions in the control group. The efficacy of the two groups was evaluated by Fugl-Meyer Motor Assessment (FMA) scale, Modified Ashworth scale (MAS) and Modified Barthel Index (MBI) scale before treatment and at 2 weeks after treatment, respectively. Results The FMA scores after treatment were significantly higher than pre-treatment scores in two groups, the FMA scores in the observation group were significantly higher than those in the control group, and the difference of the FMA scores between pre- and post-treatment in the observation group was significantly larger compared with that in the control group (all P<0.05). After treatment, the MAS grade was decreased compared with that before treatment in two groups, and the degree of grade decrease in the observation group was greater than that in the control group (all P<0.05). The MBI scores after treatment were higher than those before treatment in two groups, the MBI scores in the observation group were higher than those in the control group, and the difference of the MBI scores between pre- and post-treatment in the observation group was larger than that in the control group (all P<0.05). Conclusion Repetitive facilitative exercise combined with low-frequency acupoint electrical stimulation therapy yields high efficacy in the recovery of upper limb motor function, mitigation of muscular spasm and improvement of daily living capability after stroke. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Clinical Healthcare is the property of Chinese Journal of Clinical Healthcare and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: Postmenopausal osteoporosis significantly increases the risk of fracture, which seriously affects the quality of life of patients. Exercise therapy is an important non-drug means and prevention and treatment strategy for patients with osteoporosis, in which strength training is the best mode, but its specific biological mechanism has not been determined. OBJECTIVE: To investigate the effects of strength training on bone morphology, materials and biomechanics in ovariectomized rats and to explore the mechanism of extracellular matrix remodeling. METHODS: Forty-eight female Sprague-Dawley rats were divided into sham operation group, sham operation exercise group, ovariectomized group and ovariectomized exercise group according to the random number table method. The menopausal animal model was established by bilateral ovariectomy in the ovariectomized group and ovariectomized exercise group, while sham operation was performed in the sham operation group and sham operation exercise group. Four weeks after operation, the sham operation exercise group and the ovariectomized exercise group underwent 12-week tail weight-bearing ladder training, and the sham operation group and the ovariectomized group were raised quietly in the cage. The bilateral femur and tibia were separated after training. The right tibia was used for dual-energy X-ray densitometry and biomechanical, biophysical and biochemical analyses, the left tibia was detected using micro-computed tomography for bone microstructural examination, the right femur was subjected to hematoxylin-eosin staining for histological observation, and the left femur was used for western blot and gelatin zymography detection of protein expression and enzyme activity of extracellular matrix metabolismrelated factors, respectively. RESULTS AND CONCLUSION: Compared with the sham operation group, the maximal load and stiffness decreased (P < 0.05), bone density, bone mineral density, bone inorganic matter content, bone calcium content decreased (P < 0.05), bone water content increased (P < 0.05), trabecular bone volume fraction, trabecular connectivity density, and trabecular number decreased (P < 0.05), trabecular separation, structural model index increased (P < 0.05), bone adipocyte number and cross-sectional area increased (P < 0.05), matrix metalloproteinase-2 activity decreased (P < 0.05), and protein expression of tissue inhibitor of metalloproteinase-1 and osteoprotegerin increased (P < 0.05) in the ovariectomized group. Compared with the ovariectomized group, the maximal load, stiffness, fracture load and resilience increased (P < 0.05), bone mineral density, bone mineral content, bone mineral density, bone inorganic matter content, and bone calcium content increased (P < 0.05), bone water content decreased (P < 0.05), trabecular separation and bone marrow area decreased (P < 0.05), trabecular bone thickness, cortical bone volume fraction, cortical bone area fraction, cortical bone thickness, and cortical bone porosity increased (P < 0.05), bone adipocyte number and cross-sectional area reduced (P < 0.05), matrix metalloproteinase-2 activity increased (P < 0.05), and protein expression of tissue inhibitor of metalloproteinase-1, Runt-related transcription factor 2 and osteoprotegerin decreased (P < 0.05) in the ovariectomized exercise group. To conclude, strength training can protect against bone injury caused by estrogen deficiency, which is characterized by improvement of bone biomechanical properties, bone tissue composition and bone microstructure, and its mechanism is related to the regulation of extracellular matrix remodeling. [ABSTRACT FROM AUTHOR]

Intracerebral hemorrhage (ICH) is a serious disease that endangers human health. Dysfunction after ICH brings a high disability rate and has become a serious public health problem. Therefore, it is very important to explore effective rehabilitation methods for the prevention and treatment of ICH. The effectiveness of exercise therapy in improving dysfunction after ICH is obvious. It can promote angiogenesis, nerve regeneration and synaptic plasticity, and reduce inflammatory response, oxidative stress and apoptosis after ICH to play a neuroprotective role. However, the molecular mechanism by which exercise therapy plays a neuroprotective role in ICH remains unknown. Therefore, this article reviewed the clinical and animal experimental evidence of exercise therapy in the prevention and treatment of ICH, in order to reveal the potential neuroprotective mechanism of exercise therapy, and provide a theoretical basis for exercise therapy in the field of ICH functional rehabilitation. [ABSTRACT FROM AUTHOR]

AIM: To investigate the effects of exercise training (swimming combined with wheel running) on dendritic spine remodeling in the medial prefrontal cortex of rats with autism spectrum disorder (ASD) induced by valproic acid (VPA), and to explore the roles of microtubule affinity regulating kinase 1 (MARK1), microtubule-associated protein 1A (MAP1A) and postsynaptic density protein-95 (PSD-95). METHODS: The ASD model rats and normal control rats were generated by collecting the male offspring of rats exposed to VPA or normal saline during pregnancy. The rats were randomly divided into an exercise group and a sedentary group, with 9 to 11 rats in each group. The effect of exercise on the sociability of the rats with ASD was evaluated by a social behavior test. The density and morphology of dendritic spines in the prelimbic cortex (PrL) and infralimbic cortex (IL) were observed following stereotaxic injection of a fluorescent virus. Western blot was used to assess the protein expression of PSD-95 and synaptophysin (Syn), and RNA in situ hybridization was used to determine the RNA expression and colocalization of MARK1, MAP1A and PSD-95. RESULTS : The time spent in the chamber containing an unfamiliar rat and the time and frequency of sniffing the unfamiliar rat were significantly lower in the ASD model group than that in the control group, demonstrating that the sociability of the ASD model rats was impaired (P<0. 05). After exercise intervention, the social behavior of the ASD model rats significantly improved (P<0. 05). The total spine density, mushroom spine density, and stubby spine density were significantly increased in the PrL but not in the IL of the ASD model rats, and these changes were effectively reversed after exercise intervention. Western blot analysis showed that exercise intervention effectively abrogated the increase in the protein expression of PSD-95 in the PrL of the ASD model rats (P<0. 05). However, the expression of Syn in the PrL and the expression of PSD-95 and Syn in the IL were not significantly different. RNA in situ hybridization experiments showed that exercise intervention effectively reduced the number of RNA-positive particles of MARK1, MAP1A and PSD-95 in the PrL of the ASD model rats and reduced the colocalization of MARK1 and MAP1A, MARK1 and PSD-95 and MAP1A and PSD-95. CONCLUSION: Exercise intervention may improve the remodeling of dendritic spines through MARK1/MAP1A/PSD-95 signaling in the PrL, thereby improving the social behavior of ASD model rats. [ABSTRACT FROM AUTHOR]

OBJECTIVE: With the increasing aging population, the decline of cognitive ability in older adults has received widespread attention. High-intensity interval training (HIIT) has been applied as an emerging exercise intervention to improve cognitive ability in older adults, but its efficacy is still controversial. This study aimed to investigate the effects of HIIT intervention on cognitive ability in older adults, in order to provide a theoretical basis for its application in improving cognitive ability in older adults. METHODS: Randomized controlled trials regarding the effect of HIIT on cognitive ability in older adults were retrieved from databases including CNKI, WanFang, PubMed, Embase, and Web of Science, from the database inception to November 2022. The Cochrane Collaboration’s tool for assessing risk of bias in randomized controlled trials was used to evaluate the methodological quality, and RevMan 5.3 software was used for the Meta-analysis of outcome indicators in the included literature. RESULTS: A total of 8 randomized controlled trials, including 4 high-quality and 4 low-quality studies with 369 participants, were included in the Meta-analysis. Meta-analysis showed that (1) compared with moderate-intensity continuous training (MICT), HIIT could effectively improve the maximal oxygen uptake of older adults [weighted mean difference (WMD)=3.78, 95% confidence interval (CI): 2.79, 4.77, P < 0.000 01]. Subgroup analysis showed that with long-term intervention (intervention period ≥ 6 weeks), compared with the MICT group, the HIIT group could significantly improve the executive function [standardized mean difference (SMD)=0.36, 95%CI: 0.20-0.52, P < 0.000 1) and its sub-function inhibition ability (SMD=0.35, 95%CI: 0.17-0.52, P < 0.000 1) of older adults. (2) Compared with the control group, the HIIT group could effectively improve the maximal oxygen uptake of older adults (WMD=6.75, 95%CI: 4.20-9.29, P < 0.000 01), memory (SMD=0.20, 95%CI: 0.03-0.37, P=0.02), executive function (SMD=0.87, 95%CI: 0.52-1.22, P < 0.000 01), and its sub-function inhibition ability (SMD=0.89, 95%CI: 0.46-1.33, P < 0.000 1). Subgroup analysis showed that with long-term intervention (intervention period ≥ 6 weeks), compared with the control group, the HIIT group could effectively improve the executive function (SMD=0.75, 95%CI: 0.41-1.09, P < 0.000 1), its sub-function inhibition ability (SMD=0.50, 95%CI: 0.19-0.81, P=0.002), and switching ability (SMD=1.65, 95%CI: 0.86-2.44, P < 0.000 1). (3) With a single intervention, compared with the control group, the HIIT group could effectively improve the executive function (SMD=1.25, 95%CI: 0.39-2.11, P=0.004) and its sub-function inhibition ability (SMD=2.40, 95%CI: 0.87-3.92, P=0.002). CONCLUSION: HIIT can effectively improve the executive function and its sub-function inhibition ability of older adults, but has no improvement effect on memory ability. At the same time, long-term HIIT intervention is superior to MICT in improving aerobic capacity and executive function of older adults. [ABSTRACT FROM AUTHOR]

BACKGROUND: Patients with Alzheimer’s disease mainly show cognitive and memory dysfunctions. Aerobic exercise can inhibit endoplasmic reticulum stress and improve cognitive function of the patients. However, whether aerobic exercise can inhibit endoplasmic reticulum stress dependent neuroinflammation is still unclear. OBJECTIVE: To explore the effect of aerobic exercise on neuroinflammation and cognitive impairment in a mouse model of Alzheimer’s disease. METHODS: Fifty C57BL/6J wild-type male mouse mice were randomly divided into wild-type control and wild-type exercise groups, while another 50 APP/ PS1 double transgenic male mice were randomly divided into Alzheimer’s disease group and Alzheimer's disease exercise group, with 25 mice in each group. Mice in the wild-type exercise and Alzheimer's disease exercise groups received aerobic exercise training (treadmill training, 45 min/d, 12 m/min, 5 d/wk, 8 weeks in total). Mice in the wild-type control and Alzheimer’s disease groups were placed on the quiet running platform. Morris water maze test was used to detect the cognitive ability of mice. Hematoxylin-eosin staining and Nissl staining were used to detect hippocampal tissue damage in mice. Thioflavin-S staining was used to detect β-amyloid content in hippocampal tissue. Immunohistochemistry was used to detect β-amyloid and p-Tau levels in hippocampal tissue. Immunofluorescence staining was used to detect the number of positive cells for neuroinflammation-related factors in hippocampal tissue. Western blot was used to detect p-IRE1, IRE1, p-PERK, PERK, ATF6, GRP78, Bip, Caspase-12, Iba-1, and GFAP protein levels. RESULTS AND CONCLUSION: Compared with the wild-type control group, escape latency was increased, the number of times they reached the previous platform and the time they stayed on the platform were decreased, β-amyloid and Tau levels, p-IRE1/IRE1, p-PERK/PERK, ATF6, GRP78, Bip, Caspase-12, Iba-1, and GFAP protein levels, Iba-1+, Iba-1+ TNF-α+, Iba-1+ IL-6+, Iba-1+ IL-1β+, GFAP+, GFAP+ TNF-α+, GFAP+ IL-6+, GFAP+ IL-1β+ positive cells in hippocampal tissue were increased, and Iba-1+ IL-4+, Iba-1+ IL-10+, GFAP+ IL-4+, GFAP+ IL-10+ positive cells were decreased in the Alzheimer’s disease group (P < 0.05). Compared with Alzheimer’s disease group, escape latency was decreased, the number of times they reached the previous platform and the time they stayed on the platform were increased, β-amyloid and Tau levels, p-IRE1/IRE1, p-PERK/PERK, ATF6, GRP78, Bip, Caspase-12, Iba-1, GFAP protein levels, Iba-1+, Iba-1+ TNF-α+, Iba-1+ IL-6+, Iba-1+ IL-1β+, GFAP+, GFAP+ TNF-α+, GFAP+ IL-6+, and GFAP+ IL-1β+ positive cells in hippocampal tissue were decreased, and Iba-1+ IL-4+, Iba-1+ IL-10+, GFAP+ IL-4+, GFAP+ IL-10+ positive cells were increased in the Alzheimer’s disease exercise group (P < 0.05). To conclude, aerobic exercise can reduce cognitive impairment in Alzheimer’s disease mice by inhibiting endoplasmic reticulum stress and neuroinflammation in hippocampal tissue. [ABSTRACT FROM AUTHOR]

BACKGROUND: Exercise improves Alzheimer’s disease, dementia, and age-related cognitive abilities. A potential mediator between exercise and these health benefits may be adult hippocampal neurogenesis. Therefore, it is of great significance to explore whether and how exercise affects the adult hippocampal neurogenesis process in Alzheimer’s disease mice. OBJECTIVE: To observe the effect of aerobic exercise on adult hippocampal neurogenesis of Alzheimer’s disease mice, and to explore whether aerobic exercise can promote their adult hippocampal neurogenesis. METHODS: Three-month-old wild-type (C57BL/6Jnju) and APP/PS1 double transgenic Alzheimer’s disease mice were randomly divided into four groups: wild control group, wild exercise group, Alzheimer’s disease control group and Alzheimer’s disease exercise group, with 20 mice in each group. The control group did not do exercise, and the exercise group did aerobic exercise for 5 months. After exercise intervention, real-time PCR, immunofluorescence and western blot assay were used to detect the expression levels of DCX, Ki67, βIII-tubulin and NeuN in the hippocampal tissue of mice in each group. RESULTS AND CONCLUSION: The expressions of DCX, βIII-tubulin and NeuN in the hippocampal dentate gyrus in the Alzheimer’s disease control group were significantly lower than those in the wild control group (P < 0.05). The expressions of DCX, Ki67, βIII-tubulin and NeuN were significantly higher in the hippocampal dentate gyrus in the Alzheimer’s disease exercise group than those in the Alzheimer’s disease control group (P < 0.05). It is indicated that longterm aerobic exercise intervention can strengthen the proliferation, migration and differentiation of neurons during adult hippocampal neurogenesis and significantly increase the number of neuronal precursor cells and new neurons in Alzheimer’s disease mice. [ABSTRACT FROM AUTHOR]

The patients undergoing the treatment of assisted reproductive technology, as a special group that is different from other groups of diseases, are prone to sleep disorders due to the impact of physiological and psychosocial factors. In this review, the current status, assessment tools, and non-pharmacological intervention of sleep disorders in patients undergoing assisted reproductive technology were introduced. The appropriate tools were used to evaluate the degree of sleep disorders effectively. The appropriate intervention measures can improve the sleep quality of patients, including digital cognitive behavioral therapy, mindfulness-based stress reduction, music therapy, aerobic and resistance exercises and progressive muscle relaxation. This review will provide a reference for the evaluation of sleep disorders and non-pharmacological intervention for those patients undergoing assisted reproductive technology for pregnancy. [ABSTRACT FROM AUTHOR]

Objective: To compare the intervention effects of neck resistance training in different postures on chronic nonspecific neck pain(CNSNP)and explore a more efficient exercise therapy for CNSNP. Method: Fifty- one CNSNP patients (age 41.0 ± 5.0 years) were randomly divided into three groups: prone neck resistance training group (group A, n=17), sitting neck resistance training group (group B, n=17) and prone control group (group C, n=17). The test measures included visual analog score (VAS), Neck Disability Index (NDI), craniocervical Angle (CVA), cervical range of motion (ROM), and Root Mean Square (RMS) of neck muscles. All measures were measured before intervention and 4 weeks after intervention. Result: The intervention effect of group A was better than that of group B and group C. Neck pain score (VAS), Neck Disability Index (NDI), craniocervical Angle (CVA), cervical flexion range of motion (ROM), cervical extension range of motion(ROM), RMS(superior tract of the trapezius muscle, flexion；Sternocleidomastoid muscle, resting; Sternocleidomastoid muscle, extension) were significantly different from those in groups B and C(P＜0.05). There was no significant difference in RMS (upper tract of the trapezius muscle, resting) between Group A and Group B(P＞0.05), but there was a significant difference from Group C(P＜ 0.05). Conclusion: Neck resistance training in the prone position can more effectively reduce the VAS and RMS of neck muscles and increase the ROM and CVA of neck muscles. Author's address College of Sports Science and Health, Capital University of Physical Education and Sport, Beijing, 100191 [ABSTRACT FROM AUTHOR]

Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: Mitochondrial quality control is a complex process, which involves three aspects: mitochondrial biogenesis, mitochondrial dynamics change and mitochondrial autophagy, among which mitochondrial dynamics change is the intermediate link between mitochondrial biogenesis and mitochondrial autophagy. Mitochondria can improve their own quality control through dynamics change and then maintain their stable state. OBJECTIVE: To explore the molecular mechanism underlying the influence of exercise on mitochondrial dynamics, so as to provide theoretical basis for improving mitochondrial network homeostasis and promoting functional health. METHODS: Using the method of literature review, CNKI, Bailianyun Library, PubMed, Web of Science, EBCSO were searched for relevant literature with the keywords of “Exercise, Mitochondrial Steady State, Mitochondrial Quality Control, Mitochondrial Dynamics, Mitochondrial Fusion and Mitochondrial Division” in Chinese and English. The finally obtained literature was screened, read, and summarized. RESULTS AND CONCLUSION: Dynamin-related proteins 1/2 are responsible for mitochondrial fission, while mitofusins 1/2 and optic atrophy type 1 mediate the fusion of outer membrane and inner mitochondrial membranes respectively. Exercise training can improve the function of mitochondria by up-regulating the protein expression of mitofusins 1/2 and optic atrophy type 1 and down-regulating the protein expression level of dynamin-related protein 1, promoting mitochondrial fusion and inhibiting mitochondrial fission. The findings that a single acute exercise affects changes in mitochondrial dynamics are controversial. Furthermore, there is tissue variability in exercise-mediated changes in mitochondrial dynamics. [ABSTRACT FROM AUTHOR]

After lung cancer surgery, lung function impairment is an unavoidable issue in clinical practice, with factors such as surgical methods, resection sites, and individual differences leading to variations in the extent of lung function loss and recovery time points. This article summarizes the introduction and role of lung function tests, the effects of different surgical methods, resection sites, and physical rehabilitation training on lung function. The aim is to compare the extent of lung function loss in patients undergoing different surgical methods and resection sites, providing a reference for developing personalized exercise rehabilitation care plans for patients. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Clinical Healthcare is the property of Chinese Journal of Clinical Healthcare and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: Lower limb peri-knee muscle strength training and neuromuscular electrical stimulation are generally safe and effective rehabilitation methods for patellofemoral joint pain, but the mechanism of their intervention is still unclear. OBJECTIVE: To determine the effect of muscle strength training combined with neuromuscular electrical stimulation on pain, lower extremity function and biomechanical characteristics in patients with patellofemoral pain. METHODS: Thirty-seven patients with patellofemoral pain were randomly divided into muscle strength training combined with electrical stimulation group (trial group, n=19) and muscle strength training group (control group, n=18). Both groups underwent intervention training for 6 weeks, three times a week. The visual analog scale and anterior knee pain scale were used to evaluate the pain level and functional level of the knee. Kinematic and kinetics data during running were collected by using an infrared motion capture system and a three-dimensional force platform simultaneously. A two-way analysis of variance with repeated measures (group*time) was applied to analyze the data. RESULTS AND CONCLUSION: (1) After the intervention, the visual analog scale scores of the trial group and the control group were significantly decreased (P < 0.001), and the anterior knee pain scale scores were significantly increased (Ptrial group < 0.001, Pcontrol group=0.001) in the trial group and control group. The anterior knee pain scale scores of the trial group were significantly higher compared to the control group after the intervention (P=0.001). (2) The peak knee flexion angle (P=0.011), peak knee extension moment (P < 0.001), the peak knee internal rotation moment (P=0.008), the peak patellofemoral stress (P < 0.001) and the peak patellofemoral contact force (P < 0.001) were significantly decreased in the trial and control groups during running after the intervention compared with those before the intervention. (3) In conclusion, both muscle strength training and muscle strength training combined with electrical stimulation training are helpful to improve the subjective pain and lower limb function of patellofemoral pain patients, enhance the movement pattern during running and reduce the stress of the patellofemoral joint. Compared with muscle strength training alone, muscle strength training combined with electrical stimulation can improve lower limb function more significantly. [ABSTRACT FROM AUTHOR]

BACKGROUND: Skeletal muscle insulin resistance is the key pathological link of type 2 diabetes. Static exercise can effectively improve skeletal muscle insulin resistance, but the mechanism remains unclear. OBJECTIVE: To explore the mechanism of static exercise on insulin resistance in the skeletal muscle of type 2 diabetic mice based on the phosphatidyl inositol 3-kinase (PI3K)/protein kinase B (AKT)/glucose transporter (GLUT4) signaling pathway. METHODS: After 1 week of adaptive feeding, 7 out of 40 C57BL/6 mice were randomly selected as blank group and fed common diet, while the other mice were fed high-fat diet and taken to prepare type 2 diabetes models through the low-dose streptozotocin intraperitoneal injection. Twenty-four mice were successfully modeled and they were randomly divided into model group (n=8), metformin group (n=8) and static exercise group (n=8), which continued to be fed high-fat diet. The metformin group was given 200 mg/kg metformin dissolved in normal saline (2 ml/kg) by gavage, once a day, for 6 weeks. The static exercise group was given normal saline daily by gavage and carried out static exercise, 30 minutes a day, 6 days per week. The model group was given the same dose of normal saline daily by gavage without exercise intervention. After the intervention, the fasting blood glucose of each group was detected, the intraperitoneal glucose tolerance test was performed, and the area under the glycemic curve was calculated. Glycosylated hemoglobin, serum insulin, insulin resistance index were detected by ELISA. Total cholesterol, triglyceride, high-density lipoprotein, low-density lipoprotein were detected using biochemical methods. The mRNA expression levels of PI3K, AKT and GLUT4 in the gastrocnemius of mice were detected by real-time quantitative PCR. Morphological changes of the gastrocnemius were observed by hematoxylin-eosin staining, and the cross-sectional area of muscle fibers was calculated. RESULTS AND CONCLUSION: Compared with the blank group, fasting blood glucose, glycosylated hemoglobin, area under the glycemic curve, insulin resistance index, total cholesterol, triglyceride and low-density lipoprotein levels were significantly increased in the model group (P < 0.01, P < 0.05). Whereas, these indicators were significantly lower in the static exercise and metformin group than the model group (P < 0.01, P < 0.05). Compared with the blank group, serum insulin and high-density lipoprotein levels were significantly declined in the model group (P < 0.01) and the mRNA expression of PI3K, AKT and GLUT4 in the gastrocnemius of mice were also significantly reduced (P < 0.01). These indicators were significantly elevated in the metformin group and static exercise group compared with the blank group (P < 0.01). Compared with the blank group, the muscle fibers in the model group were disordered, and the muscle cells atrophied and the muscle fiber gap widened. The cross-sectional area of muscle fibers was significantly decreased in the model group compared with the blank group (P < 0.01). Compared with the model group, atrophy of the gastrocnemius fibers and muscle fiber space were improved in the static exercise group and the metformin group, and the cross-sectional area of muscle fiber was significantly increased in both groups (P < 0.01). These findings indicate that static resistance training may promote glucose uptake and utilization by up-regulating the expression of PI3K, AKT and GLUT4 mRNA in skeletal muscle tissue, thereby improving the morphology and function of skeletal muscle tissue, alleviating insulin resistance and regulating glucose homeostasis. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: Resistance exercise increases muscle mass and improves muscle strength, but there is a lack of conclusive evidence on its effects on body composition. Controversial results from randomized controlled trials and multiple Meta-analyses pose a problem for clinical decisions on exercise interventions. OBJECTIVE: Based on the methodological paradigm of umbrella review, to explore the efficacy and safety of resistance exercise in improving the body composition of overweight and obese people. METHODS: We searched PubMed, Cochrane Library, Web of Science, and CNKI for systematic reviews on the effect of resistance exercise in overweight and obese people published from database inception to August 31, 2022. Chinese search terms included “anti-resistance, resistance, self-weight, Meta, Metaanalysis, body composition, body fat percentage, fat mass, lean body mass, body mass.” English search terms included “resistance training, strength training, weight-lifting strengthening program, body composition, body fat distribution, Meta-analysis, data pooling, overviews, clinical trial, clinical trial overviews.” PRISMA was used to evaluate the methodological quality of the included studies, and a GRADE evaluation system was used to grade the quality of evidence. RESULTS AND CONCLUSION: A total of 14 Meta-analyses were included, and GRADE evidence quality evaluation showed that 2 outcome indicators were intermediate, 12 were low, and 14 were extremely low. Compared with the control group, 23 of the 32 outcome measures showed significant improvement. The intervention effect of resistance exercise on body fat percentage has reached a consensus, but the intervention effects on lean body mass, body mass index and visceral fat still need further confirmation. Resistance exercise is an effective and safe method to improve the body composition of overweight and obese people. The overall quality of the research and the evidence quality of the outcome indicators included in the systematic evaluation are generally low. In the future, the initial state, exercise goal and willingness of the subjects should be fully combined on the basis of clarifying the sample characteristics and refining the scheme design. Through multiple, scientific and personalized exercise prescription designs of water, air and elastic resistance, the safety and compliance of resistance exercise can be improved, providing clear evidence-based support and decision-making basis for resistance exercise intervention. [ABSTRACT FROM AUTHOR]

BACKGROUND: In recent years, with the improvement of living standards, non-alcoholic fatty liver disease has a gradually increasing trend. miRNA-122 is one of the most abundant microRNAs in the liver, which plays an important role in maintaining the environmental stability and differentiation of the liver. Exercise training is a non-drug treatment for non-alcoholic fatty liver disease, which may improve liver lipid metabolism by regulating the expression of miRNA-122. OBJECTIVE: To review the effects of miRNA-122 on the pathological factors related to non-alcoholic fatty liver disease as well as the effects of exercise on the expression of miRNA-122 and the occurrence and development of nonalcoholic fatty liver disease. METHODS: The first author searched the databases of CNKI, WanFang, VIP, PubMed, Geenmedical, EBSCO, Medline, Web of Science, and Elsevier using “non-alcoholic fatty liver disease, microRNA, microRNA-122, lipid metabolism, inflammatory response, insulin resistance, exercise, physical exercise, exercise training” as the English and Chinese search terms for all relevant literature published before June 5, 2022. All included documents were screened, summarized, and analyzed. Finally, 68 documents were included for review. RESULTS AND CONCLUSION: Compared with the healthy control group, the expression of circulating miRNA-122 is increased in patients with non-alcoholic fatty liver disease. The level of miRNA-122 may show different expression levels at different stages of non-alcoholic fatty liver disease. miRNA-122 can regulate the expression of downstream-related proteins, influence lipid metabolism, inflammatory response, insulin resistance and other pathogenic factors in nonalcoholic fatty liver disease by targeting base complementary pairing sites on mRNA or directly acting as physiological ligands of some RNA receptors. Different exercise modes can improve non-alcoholic fatty liver disease. Therefore, patients with non-alcoholic fatty liver disease need to complete at least 120 minutes of moderate-intensity exercise every week to have a positive effect. For patients who can tolerate various exercises, priority should be given to the combination of aerobic and resistance exercises 4-5 times a week. The exercise intensity should be 50%-70% of the maximum heart rate and the exercise should last for > 3 months. For patients with poor tolerance, resistance exercise may be more feasible than aerobic exercise. In addition, patients with non-alcoholic fatty liver disease can also choose proper exercise modes according to their own disease conditions (such as liver enzymes and lipid levels). Exercise can be used as a feasible strategy to prevent non-alcoholic fatty liver disease, reduce liver steatosis, and alleviate liver inflammatory response and insulin resistance. Exercise training can regulate the expression of miRNA-122, but in patients with non-alcoholic fatty liver disease, the effect of exercise on miRNA-122 and its related signal pathways remains to be studied. [ABSTRACT FROM AUTHOR]

Objective: To explore the influence of metformin combined with exercise therapy on the clinical effect of patients with gestational diabetes mellitus（GDM). Methods: 89 patients with gestational diabetes admitted to Beijing Aerospace General Hospital from March 2020 to March 2022 were were randomly divided into observation group（n=45） and control group（n=44） according to the coin toss method. The control group was given metformin hydrochloride tablets orally, while the observation group was given exercise therapy on the basis of the control group.The clinical efficacy, blood glucose indicators, oxidative stress indicators, inflammatory factor levels,pregnancy outcomes, and adverse reactions of the two groups of patients were compared. Results: After treatment, After treatment, the total effective rate of clinical efficacy in the observation group was 93.33%（42/45), which was higher than 75.00%（33/44） in the control group（P＜0.05). After treatment, fasting blood glucose（FPG), 2 h plasma glucose（2hPG), and glycosylated hemoglobin（HbAlc） in both groups decreased, and the observation group was significantly lower than the control group（all P＜0.05). After treatment, the levels of superoxide dismutase（SOD） in both groups increased and the observation group was significantly higher than the control group, while the levels of malondialdehyde（MDA） and reactive oxygen species（ROS） decreased and the observation group was significantly lower than the control group（all P＜0.05). After treatment, the level of hypersensitive C-reactive protein（hs-CRP), tumor necrosis factor（TNF-α), interleukin-6（IL-6） in both groups decreased and the observation group was significantly lower than that in the control group（all P＜0.05). The incidence of cesarean section and premature delivery in the observation group was lower than that in the control group（all P＜0.05). There was no difference in the total incidence of adverse events between the two groups during treatment（P＞0.05). Conclusion: Metformin combined with exercise therapy can effectively control blood glucose levels in GDM patients, optimize oxidative stress indicators, reduce inflammatory factor levels, and improve pregnancy outcomes, and has certain safety. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective:To explore the clinical study of single inhaler triple therapy combine with early pulmonary rehabilitation exercise training for the treatment in patients with moderate to severe chronic obstructive pulmonary disease (COPD) .Methods:According to the random number table method,84 patients with moderate to severe COPD who were admitted to The Second Affiliated Hospital of Shantou University Medical College from July 2022 to January 2023 were divided into control group (42 cases,treated with single inhaler triple therapy) and experimental group (42 cases,treated with early pulmonary rehabilitation exercise training on the basis of control group) .The pulmonary function indicators[forced vital capacity (FVC),forced expiratory volume in one second (FEV1),FEV1/FVC],blood gas analysis indicators[degree of blood oxygen saturation (Sa O2),arterial partial pressure of oxygen (Pa O2),arterial partial pressure of carbon dioxide (Pa CO2) ],6-minute walking distance (6MWD),COPD assessment test (CAT) scores,frequency of acute exacerbation during treatment,and serum inflammatory factors[tumor necrosis factor-α (TNF-α),interleukin-6 (IL-6),C-reactive protein (CRP) ]were observed and compared in two groups.Results:After treatment,the FEV1,FVC and FEV1/FVC in experimental group were higher than those in control group (P＜0.05) .After treatment,the Pa CO2in experimental group was lower than that in control group,while the Pa O2and Sa O2in experimental group were higher than those in control group (P＜0.05) .After treatment,6MWD in experimental group was higher than that in control group,while the CAT scores and frequency of acute exacerbation during treatment in experimental group were lower than those in control group (P＜0.05) .After treatment,serum TNF-α,IL-6 and CRP levels in experimental group were lower than those in control group (P＜0.05) .Conclusion:Single inhaler triple therapy combine with early pulmonary rehabilitation exercise training for the treatment in patients with moderate to severe COPD,which can enhance the exercise endurance,improve the ability of life activities,reduce the frequency of diseases acute exacerbation during treatment,it can also improve blood gas analysis and pulmonary function indicators,and reduce serum inflammatory factor levels. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Clinical Healthcare is the property of Chinese Journal of Clinical Healthcare and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To evaluate the application effect of home-based exercise therapy in community-dwelling elderly patients with mild cognitive impairment (MCI) and depression. Methods From January 2021 to December 2022, 60 community-dwelling elderly patients with MCI and depression who were screened at medical institutions were randomly divided into the control group and the intervention group. According to the basic requirements of national public health service, community medical staff carried out group follow-up once every quarter, and patients were intervened by general lifestyle interventions and health education for 6 months. On the basis of routine interventions, the intervention group received home-based exercise therapy for 6 months. The Geriatric Depression Scale(GDS), The Montreal Cognitive Assessment (MoCA), Brathel Index (BI) for Activity of Daily Living were adopted for effectiveness assessment of exercise therapy on cognitive function, depression level and daily living ability of patients. Results After 6 months of intervention, the score ofGDS in the intervention group was lower than that in the control group, with a significant difference (P＜0. 01); The total score of MoCA and subscale scores of Visuospatial/Executive, Attention, Language, Abstraction, Delayed recall and Orientation in the intervention group were higher than those in the control group (P＜0. 01); The score of BI in the intervention group was higher than that in the control group, with a significant difference (P＜0. 01). Conclusion Home-based exercise therapy can alleviate the depressive symptoms, improve the cognitive function and activity of daily living among community-dwelling elderly patients with MCI and depression (目的 探讨以家庭为基础的运动疗法对社区老年轻度认知障碍(MCI)伴抑郁患者的影响。方法 选取2021年1月—2022年12月, 经医疗机构筛查并居住在上海市奉贤区社区的60名MCI伴抑郁症状的患者, 随机分为对照组和干预组。对照组依据国家基本公共卫生服务要求, 由课题组成员在相应社区每季度开展团体讲座, 普及MCI相关健康教育知识, 饮食、运动等生活方式, 干预6个月; 干预组在对照组的基础上, 增加了以家庭为基础的运动疗法, 干预6个月。对比两组患者老年抑郁量表(GDS)、蒙特利尔认知评估量表(MoCA)和Barthel指数评定量表(BI)得分情况。结果 干预后, 干预组GDS量表评分低于对照组, 差异有统计学意义(P＜0. 01); 干预组MoCA量表视空间与执行能力、注意力、语言功能、抽象思维、延迟回忆和定向力维度评分以及总分高于对照组, 差异有统计学意义(P＜0. 01); 干预组患者BI量表评分较对照组提高, 差异有统计学意义(P＜0. 01)。结论 以家庭为基础的运动疗法可以缓解社区老年MCI伴抑郁患者的抑郁症状, 改善认知功能, 提高日常生活能力, 并延缓MCI病情进展。)

The prevalence of overweight and obesity has been increasing yearly and become a global public health problem with a range of consequences causing widespread concern. Weight loss can reduce the incidence of type 2 diabetes, cardiovascular risk, and all-cause mortality. The most common approaches of weight loss are drug therapy, surgery and lifestyle interventions including diet and exercise, however, exercise intervention remains the healthiest and most fundamental approach of weight loss. Exercise can reduce cellulite, increase muscle mass and improve metabolism. The combination of exercise and other weight loss approaches can reduce adverse reactions and produce better results. Continuing exercise after weight loss can also effectively prevent rebound and maintain weight loss effects. This paper reviews the definition, mechanism, effect, and management of "exercise is the foundation of weight loss", and provide a reference for weight loss through exercise in the context of the experience of Zhongda Hospital.

Background Adolescent idiopathic scoliosis (AIS) is a progressive three-dimensional skeletal deformity that affects spinal mobility and trunk symmetry. It was previously believed that AIS was not accompanied with pain, but recent studies have shown that approximately 31.5% of the patients complain of low back pain, which may due to factors such as paravertebral muscle imbalance and fatigue. Objective To observe morphological changes of paravertebral multifidus muscles at the top of the main curvature after high energy laser therapy (HILT) combined with physiotherapy scoliosis specific exercise (PSSE) in AIS patients with low back pain by using musculoskeletal ultrasound. and evaluate the clinical effect of treatment on the correction of paravertebral muscle imbalance. Methods A total of 30 patients with AIS RigoE1 admitted to the Scoliosis Correction Center of the Fifth Hospital of Harbin from December 2020 to December 2021 were selected for a randomized single-blind controlled trial and divided into the experimental group (n=15) and control group (n=15) , the experimental group was treated with HILT combined with PSSE, and the control group was only treated with HILT. Musculoskeletal ultrasound, visual analogue scale (VAS) scores, range of motion of the patient's lumbar joints and Roland-Morris lumbar spine dysfunction questionnaire (RDQ) were performed before and 4 weeks after treatment in both groups. Pearson correlation analysis was used to investigate whether there was a correlation between the changes in the multifidus muscles after treatment and the treatment effect. Results The cross-sectional area of the convex side of multifidus muscles, anterior flexion, left lateral flexion, left rotation and right rotation of the experimental group were higher than those of the control group after treatment (P

Depressive disorder, as one of the major diseases in the world, has always received much attention for its prevention and treatment. As an emerging treatment, exercise therapy has optimistic application prospect with the advantages such as lower cost, fewer side effects and easier implementation, compared to conventional treatments such as drug therapy and physical therapy. Relevant studies have explored the mechanism of exercise in the treatment of depressive disorder, but the mechanism is not clear yet, which may involve improving the levels of neurobiochemical molecules, inhibiting inflammatory response, regulating neuroendocrine system, improving neuroplasticity, and other aspects. Exercise therapy has been proved to have similar biological effects with antidepressants, and may have overlapping effects with other treatments. Early intervention can benefit both non- diseased and already diseased populations to a certain extent. At present, there is still a gap in the clinical field related to exercise therapy for depressive disorder, and there are few high-quality studies. The design of exercise therapy plans is still in the exploratory stage, and there is no consensus on the design of exercise therapy plans. Additionally, there is a lack of relevant exercise therapy guidelines for clinicians to refer to. This review systematically introduces the biological mechanism of exercise therapy for depressive disorder, summarizes the clinical research results in this field carried out at home and abroad, and analyzes the current program and advantages and disadvantages of exercise therapy, in order to provide reference for the in-depth development of the exercise therapy researches.

BACKGROUND: Beta-amyloid (Aβ) accumulation and deposition in the hippocampus can affect synaptic morphology and function, resulting in impaired synaptic plasticity, which is considered to be the root cause of learning and memory deficits of Alzheimer’s disease. It is not yet clear whether aerobic exercise can alleviate Aβ-induced synaptic damage and improve the learning and memory abilities of patients with Alzheimer’s disease. OBJECTIVE: To observe the effect of aerobic exercise on the hippocampal synaptic structure and synapse marker proteins, synaptophysin and postsynaptic dense 95, in a rat model of Alzheimer’s disease induced by Aβ1-42, so as to investigate the mechanism by which aerobic exercise influences learning and memory ability of patients with Alzheimer’s disease. METHODS: Eighty healthy Sprague-Dawley rats were randomly divided into four groups (n=20 per group): control group, exercise group, Aβ1-42 model group, and Aβ1-42 exercise group. Rats in the latter two groups were injected with 10 μL of Aβ1-42 (1 μg/μL) into the bilateral hippocampi, while those animals in the former two groups were injected 10 μL of normal saline in the same way. Rats in the two exercise groups began aerobic exercise training on the 2nd day after injection and the training lasted for 5 weeks, 6 days per week. Morris water maze test was conducted to test the spatial learning and memory ability of rats. Then brain tissue samples of rats were taken. The hippocampal synaptic structure and the expression of synaptophysin and postsynaptic dense 95 in the hippocampus were detected by electron microscopy, immunofluorescence, and western blot assay. RESULTS AND CONCLUSION: (1) In the Morris water maze test, the average escape latency of all rats was gradually shortened during the location-based navigation training. The average escape latency decline rate of the Aβ1-42 exercise group was slower than that of the control group but showed a faster trend compared with that of the Aβ1-42 model group. (2) In the space exploration experiment, the frequency of platform crossing and retention time in the target quadrant were significantly lower in the Aβ1-42 exercise and Aβ1-42 model groups than the control group (P < 0.01, P < 0.05), but were significantly increased in the Aβ1-42 exercise than the Aβ1-42 control group (P < 0.05). Moreover, there was no significant difference between the exercise and control groups (P > 0.05). (3) Under the electron microscope, compared with the control group, the number of synapses decreased (P < 0.01) and the thickness of postsynaptic compacts became thinner in the Aβ1-42 model group (P < 0.05). Compared with the Aβ1-42 model group, the Aβ1-42 exercise group had an increase in the number of synapses (P < 0.05) and the thickness of postsynaptic compacts (P < 0.05). (4) Results from the immunofluorescence and western blot detections showed that the expressions of postsynaptic dense 95 and synaptophysin in the hippocampus were significantly lower in the Aβ1-42 model group than the control group (P < 0.01, P < 0.05), while the expression levels in the Aβ1-42 exercise group was significantly higher than those in the Aβ1-42 model group (P < 0.01, P < 0.05). (5) These findings indicate that aerobic exercise can effectively reduce Aβ1-42-induced damage to the hippocampal synaptic structure and promote the expression of hippocampal postsynaptic dense 95 and synaptophysin in rats, which may be one of the mechanisms by which aerobic exercise alleviates the learning and memory impairment in Alzheimer’s disease rats caused by Aβ1-42 toxicity. [ABSTRACT FROM AUTHOR]

BACKGROUND: Postpartum diastasis rectus abdominis have a high incidence, which has a certain adverse effect on the physical and mental health of parturients. Exercise therapy is one of the main treatment methods, but there is still a lack of consensus on which exercise can promote its repair more effectively. OBJECTIVE: To observe the immediate effects of curl-up movement, abdominal breathing, pelvic floor muscle contraction and combined exercise on interrectus distance using high-frequency ultrasound. METHODS: Thirty-nine eligible subjects with postpartum diastasis rectus abdominis were recruited 2-6 months after delivery. Inter-rectus distance was measured using high-frequency ultrasound at 4.5 cm above the umbilicus, at the level of the umbilicus and at 4.5 cm below the umbilicus in five movement patterns: resting state, curl-up movement, abdominal breathing, pelvic floor contraction and combined movement. RESULTS AND CONCLUSION: There was no significant difference in the inter-rectus distance between the resting state and the other four movement patterns at 4.5 cm above the umbilicus (P > 0.05). At the level of the umbilicus, the inter-rectus distance was significantly decreased in the curl-up movement compared with the resting state (P < 0.01), while the inter-rectus distance significantly increased in the combined exercise compared with the resting state (P < 0.05). At the 4.5 cm below the umbilicus, the inter-rectus distance decreased in the curl-up movement compared with the resting state (P < 0.05), while the inter-rectus distance tended to increase in the other three movements compared with the resting state, but there was no statistical difference (P > 0.05). There was no significant difference in the inter-rectus distance between spontaneous delivery group and cesarean section group at the resting state (all P > 0.05). However, at the umbilical level, the inter-rectus distance in the multiparity group was significantly wider than that in the primiparity group (P < 0.05). At 4.5 cm below the umbilicus, the body mass index was positively correlated with the inter-rectus distance (r=0.359, P=0.025). In terms of immediate effects, curl-up movement can reduce the inter-rectus distance, while abdominal breathing, pelvic floor contraction and combined exercise have the opposite effects. Parturients with multiple births and a high body mass index may be more likely to develop postpartum diastasis rectus abdominis. Results from this study will provide a theoretical basis for the rehabilitation treatment of postpartum diastasis rectus abdominis. [ABSTRACT FROM AUTHOR]

BACKGROUND: As a new and objective method for the measurement and treatment of muscle training, pressure biofeedback can provide real-time feedback to improve the accuracy and effectiveness of deep neck flexor exercises. However, there are few reports on clinical studies related to pressure biofeedback and neck deep muscle exercise in China. OBJECTIVE: To investigate the clinical efficacy of pressure biofeedback training combined with deep neck flexor exercises in patients with chronic neck pain. METHODS: A total of 60 patients with chronic neck pain treated in the Out-Patient Department and Orthopedic Ward of the First Affiliated Hospital of Guangxi University of Chinese Medicine from April to October 2021 were enrolled in this study. These patients were selected and divided into experimental group and control group. The former group used pressure biofeedback to perform deep neck flexor exercises, while the latter group performed regular deep neck flexor exercises. The primary outcome was the peak pressure measured by pressure biofeedback at each follow-up point (1, 2, and 3 months after treatment) and the secondary outcomes were peak pressure maintenance time as well as the Northwick Park Neck Pain Questionnaire score. RESULTS AND CONCLUSION: (1) There were significant differences in peak pressure value and peak pressure maintenance time before and after exercises in the two groups (P < 0.05). Compared with the control group, the peak pressure value and maintenance time were significantly higher in the experimental group at each time point (P < 0.05). (2) The Northwick Park Neck Pain Questionnaire score in each group was significantly lowered at each time point after exercises (P < 0.05), and the score in the experimental group was significantly lower than that in the control group at 2 and 3 months after exercises (P < 0.05). (3) To conclude, pressure biofeedback combined with deep neck flexor exercises can effectively alleviate the symptoms of chronic neck pain, feedback real-time exercise results for patients, and increase the sustainability of functional exercises, which is a simple, convenient, and low-cost treatment for neck pain and can be a part of the community re-education program for prophylaxis and treatment. [ABSTRACT FROM AUTHOR]

BACKGROUND: At present, there are many treatment methods for low back pain; however, most of them cannot fundamentally solve the problem. How to effectively reduce the incidence of low back pain is worth thinking about by clinical workers. OBJECTIVE: To explore the influencing factors of low back pain in middle-aged and elderly people in China, construct a nomogram prediction model for low back pain and guide exercise and rehabilitation therapy with different intensities and frequencies according to the occurrence probability of low back pain to reduce the incidence of low back pain. METHODS: The follow-up data from the China Health and Retirement Longitudinal Study (CHARLS) in 2015 were used to determine whether low back pain occurred or not. Fourteen variables, including age, sex, marriage, place of residence, exercise, education level, smoking, alcohol consumption, depressive symptoms, body mass index, sleep duration, left hand muscle strength, right hand muscle strength and waist circumference, were used as independent variables to analyze the independent influencing factors of the occurrence of low back pain in middle-aged and elderly people and construct the nomogram prediction model. The calibration curve and receiver operating characteristic curve of the model were drawn, and the C index was calculated to evaluate the discrimination and calibration degree of the prediction model. RESULTS AND CONCLUSION: (1) A total of 6 059 middle-aged and elderly patients were selected. Patients with low back pain were selected as the disease group (n=1 263), and those without low back pain were selected as the control group (n=4 796). The original data set was constructed. The original data set was divided into training set (n=4 243) and verification set (n=1 816) at a ratio of 7:3. (2) According to the results of multivariate logistics regression analysis, four variables, including education level, depressive symptoms, sleep duration and right hand muscle strength, were identified to construct the nomogram prediction model, and the area under the receiver operating characteristic curve of the model was 0.726. The calibration curve fit was good, and the calibration curve generated by bootstrops method was good for the internal verification of the model. The validation set was used for the external verification. The area under the receiver operating characteristic curve of external verification was 0.740 and the calibration graph fit was good, indicating that the model had good discrimination and calibration degree. (3) According to the factors such as education level, depressive symptoms, sleep duration, and right hand grip strength, the probability of occurrence of low back pain can be predicted by using the nomogram prediction model, and early prevention can improve the quality of life of middle-aged and elderly people. [ABSTRACT FROM AUTHOR]

Cardiopulmonary function is a powerful indicator of overall health and cardiovascular or all-cause mortality. Exercise is an important non-pharmacological treatment modality in the prevention and management of hypertension, primarily including continuous aerobic exercise, high-intensity interval training, and resistance exercise. Different exercise patterns not only contribute to blood pressure reduction in hypertensive patients, but also effectively improve cardiopulmonary function. This article provides a review of the impact of various exercise modalities, particularly aerobic exercise, on the cardiopulmonary function of hypertensive patients, aiming to offer assistance in formulating scientific exercise intervention strategies for individuals with hypertension. [ABSTRACT FROM AUTHOR]

The design and evaluation of exercise training subject is an important part of military training， the quality and effectiveness of military training can be effectively improved by scientific training subject design and reasonable subject design and evaluation methods. In view of difficulty to design exercise training subject and the unscientific evaluation of exercise training subject， the paper analyzes the requirements of training subject design, studies the design method of training subject and training mode based on task, and proposed similarity-based the evaluation method for training subject design. The research results have formed a complete set of training project design and evaluation model, it can provide reference for the army to organize exercises and training. [ABSTRACT FROM AUTHOR]

BACKGROUND: Frailty is the result of the interaction between aging process and some chronic diseases, which increases the risk of disability and other adverse consequences due to the decline of body function. Exercise is considered to be one of the main strategies for the elderly to fight against physical injury related to frailty, but most elderly patients with frailty do not carry out any systematic exercise intervention.OBJECTIVE: To describe the research progress of different exercises in improving frailty syndrome in the elderly, thereby providing reference and basis for the pre-treatment of frailty by exercise in the elderly in different states. METHODS: A computer-based search of PubMed, Web of Science, CNKI, VIP and WanFang databases was performed for relevant articles using “exercise, physical activity, frailty, aging, multi-component intervention” as keywords in Chinese and English. Finally, 72 selected articles were summarized. RESULTS AND CONCLUSION: Among the exercise forms suitable for frailty syndrome in the elderly, aerobic training is the foundation, strength training is the core, power training and flexibility training are auxiliary, and balance training and virtual training are supplementary. Multicomponent exercise interventions are the best choice in the elderly. For the healthy elderly, aerobic and strength trainings are the main forms of exercise, supplemented by balance training, flexibility training and power training. For the elderly at the early stage of frailty, strength and aerobic trainings are the main forms of exercise, supplemented by balance training, flexibility training and power training. For the elderly with frailty, multicomponent interventions involving strength, endurance, power, balance and flexibility trainings were preferred. For the elderly inpatients, strength training is the main form of exercise, and aerobic, virtual, balance and flexibility trainings as the auxiliary forms of exercise are selected. With the increase of frailty, exercise intensity and exercise time should gradually decrease in the elderly in different states. [ABSTRACT FROM AUTHOR]

Introduction: We aimed to compare differences in pulse wave velocity (PWV) parameters between resistance-trained individuals and those without habitual aerobic training and to investigate whether the changes in myocardial perfusion and left ventricular energy waste in response to different intensities of acute resistance exercise differed between the groups. Methods: This study used a repeated measures design. Twenty-two habitually resistance-trained men were recruited and divided into a combined exercise-trained group (aerobic and resistance exercise training [RT+ET]; mean age = 23 ± 1 years; n = 11) and a resistance-trained only group (RT; mean age = 25 ± 1 years; n = 11) based on self-reported weekly aerobic exercise time (>150 minutes/week as recommended). Subjects were randomly assigned to perform a single bicep-curl at 40% or 80% 1RM (10 repetitions/set, 5 sets), respectively, after performing different PWV tests (ultrafast local carotid PWV and carotid-femoral and brachial-ankle PWV) and one-repetition maximum of bicep curls (1RM). The exercise sessions were performed at least 24 hours apart. Radial arterial waveforms were acquired before and after exercise using a vascular tonometer to obtain carotid blood pressure, subendocardial viability ratio (SEVR), and left ventricular energy waste. Systolic time intervals (STI) were also used to assess cardiac sympathetic activity. Results: The RT group had a higher PWV than the RT+ET group in all arterial stiffness measures, although these differences were not significant. A single bicep curl exercise at different intensities did not cause a significant increase in carotid arterial pressure in either group. Following exercise, RT showed an increase in carotid pulse pressure at 80% 1RM (p = .07), a significant decrease in SEVR (p = .02), and an increase in left ventricular energy waste (p = .08), which was significantly higher than that in the RT+ET group (p = .02). However, no significant changes in myocardial perfusion and left ventricular energy waste were observed in the RT+ET group after exercise. No significant changes of STI index were observed in either group. Conclusions: The attenuation of cardiac stress induced by an acute bout of high-intensity resistance exercise appears to be better in habitually combined exercise-trained young adults than in their resistance-trained only counterparts, indicating the importance of combining aerobic exercise with a regular training program in this population. [ABSTRACT FROM AUTHOR]

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OBJECTIVE: Exercise intervention is considered the cornerstone of rehabilitation after anterior cruciate ligament reconstruction. However, no clear conclusion has been reached regarding which exercise therapy is more effective in improving knee muscle strength and function in patients after anterior cruciate ligament reconstruction. To this end, this study used a network meta-analysis method to compare the efficacy of exercise therapy after anterior cruciate ligament reconstruction, providing evidence-based medical basis for selecting the best exercise therapy. METHODS: A computer search was conducted in PubMed, Web of Science, Embase, The Cochrane Library, and EBSCO to collect randomized controlled trials addressing exercise therapy following anterior cruciate ligament reconstruction. The search time limit was from the establishment of the database to 2023-11- 20. Outcome indicators included three continuous variables: quadriceps muscle strength, hamstring muscle strength, and knee joint function score. EndNote X9.1 was used for literature screening. The Cochrane risk of bias assessment tool was used to evaluate the quality of the included literature. The GRADE score was used to rate the strength of evidence for the results of the article. Network meta-analysis was performed using Stata 16.0. RESULTS: A total of 36 randomized controlled trials were included, involving 1179 patients undergoing anterior cruciate ligament reconstruction. The overall quality of the included literature was moderate. Nine types of exercise therapies were involved: isokinetic training, cross training, eccentric training, aquatic rehabilitation, blood flow restriction training, motor control training, plyometric training, whole-body vibration training, and multimodal training; the control measure was conventional rehabilitation training. The results of the network meta-analysis showed that compared with conventional rehabilitation training, eccentric training [standardized mean difference (SMD)=2.08, 95% confidence interval (CI): 0.56 to 3.60, P=0.007) had the best improvement effect on quadriceps muscle strength in patients undergoing anterior cruciate ligament reconstruction, followed by multimodal training (SMD=1.69, 95% CI: 0.11 to 3.27, P=0.249) and whole body vibration training (SMD=0.81, 95% CI: 0.11 to 1.51, P=0.042). In terms of improving patients’ hamstring muscle strength, multimodal training (SMD=2.08, 95% CI: 0.30 to 3.86, P=0.022) had the best effect, followed by plyometric training (SMD=1.51, 95% CI: 0.18 to 2.84, P=0.026) and isokinetic training (SMD=1.37, 95% CI: 0.06 to 2.67, P=0.039). Multimodal training (SMD=4.60, 95% CI: 2.40 to 6.80, P < 0.001) was the most effective in improving knee joint function scores, followed by eccentric training (SMD=1.75, 95% CI: 0.24 to 3.25, P=0.023) and aquatic rehabilitation (SMD=1.65, 95% CI: 0.07 to 3.24, P=0.041). CONCLUSION: Evidence of low to moderate strength suggests that multimodal training may be the most effective exercise therapy in improving knee muscle strength and function in patients after anterior cruciate ligament reconstruction, followed by eccentric training, plyometric training, isokinetic training, whole body vibration training, and aquatic rehabilitation. More high-quality clinical randomized controlled trials are still needed in the future to verify the reliability of the conclusions. [ABSTRACT FROM AUTHOR]

Background Exercise is one of inexpensive and effective interventions for the prevention and treatment of postmenopausal osteoporosis, but relevant pieces of evidence are wide-ranging and fragmented, and there is no standardized and comprehensive exercise guidance program on clinic. Objective To screen and assess the evidence of exercise interventions for postmenopausal osteoporosis, then summarize the best pieces. Methods We systematically searched clinical practice guidelines, clinical decisions, evidence summaries, expert consensuses and systematic reviews regarding exercise interventions for postmenopausal osteoporosis in databases of BMJ Best Practice, Up To Date, DynaMed, National Institute for Health and Care Excellence, Guidelines International Network, Scottish Intercollegiate Guidelines Network, National Guideline Clearinghouse, webs of Registered Nurses' Association of Ontario, International Osteoporosis Foundation, Royal Osteoporosis Society, National Osteoporosis Foundation, Royal Australian College of General Practitioners, American College of Obstetricians and Gynecologists, Society of Obstetrics and Gynaecologists of Canada, Medlive, JBI, Cochrane Library, CINAHL, Web of Science, PubMed, Embase, CNKI and SinoMed from inception to January 2022. All relevant evidence was summarized and extracted according to the theme. Appraisal of Guidelines for Research and Evaluation (AGREEⅡ) was used to evaluate the quality of the guidelines, Critical Appraisal for Summaries of Evidence (CASE) was used to evaluate the quality of clinical decisions, the authenticity assessment tool of the expert consensus of the JBI Evidence-Based Health Care Center in Australia (2016 edition) was used to evaluate the quality of expert consensuses, the Australian JBI Evidence-based Health Care Centre System Evaluation Methodology Quality Evaluation Tool (2016 edition) was used to evaluate the quality of the systematic reviews. Results A total of 18 studies were included, including seven guidelines, two clinical decisions, four expert consensuses and five systematic reviews. Twenty-two pieces of evidence were extracted, involving five aspects: pre-exercise assessment, exercise type, exercise intensity and time, health education and precautions. Conclusion This paper extracts the best evidence of exercise intervention for postmenopausal osteoporosis patients from five aspects: pre-exercise assessment, exercise type, exercise intensity and time, health education and precautions. To reduce the risks of falls and fractures and improve quality of life in postmenopausal women with osteoporosis, it is suggested to provide these women with rational exercise guidance developed based on the best evidence.

Objective: To analyze the influencing factors of cancer-related fatigue (CRF) in patients with non Hodgkin lymphoma (NHL) chemotherapy, and to explore the intervention effect of aerobic exercise on CRF in patients with NHL chemotherapy. Methods: 142 cases of patients with NHL chemotherapy who were admitted to The First Affiliated Hospital of Air Force Military Medical University from March 2021 to April 2022 were selected, the self-made questionnaire was used to collect data from the research subjects, a total of 142 questionnaires were distributed, and 142 questionnaires were recovered, among which 138 were valid, the effective recovery rate was 97.18%. According to the occurrence of CRF, patients were divided into CRF group (n=109) and non-CRF group (n=29). Multivariate Logistic regression was used to analyze the influencing factors of patients with CRF after NHL chemotherapy. Patients with CRF after NHL chemotherapy were given aerobic exercise intervention, and the CRF, depression and anxiety degree of patients were compared before and after intervention. Results: The CRF status of 138 patients with NHL was investigated, 109 of them had occurrence of CRF, the incidence rate was 78.99%. Univariate analysis showed that the occurrence of CRF in patients with NHL chemotherapy were related to employment situation, tumor stage, chemotherapy cycle, social support degree, Hamilton Depression Scale (HAMD) score, Hamilton Anxiety Scale (HAMA) score (P<0.05). The results of multivariate Logistic regression analysis showed that tumor with stage IV, 3~4 cycles of chemotherapy cycle, high HAMD score and high HAMA score were risk factors for CRF in patients with NHL chemotherapy, and high social support degree was a protective factor (P<0.05). After intervention, the perceptual dimension, behavioral dimension, cognitive dimension, affective dimension, and total score in the CRF group were all decreased compared with those before intervention (P<0.05). After intervention, HAMA and HAMD scores in the CRF group were decreased compared with those before intervention(P<0.05). Conclusion: The occurrence of CRF in patients with NHL chemotherapy is affected by factors such as chemotherapy cycle, HAMD score, HAMA score, and and high social support degree. And adhere to aerobic exercise can reduce fatigue, relieve depression and anxiety status. [ABSTRACT FROM AUTHOR]