非霍奇金淋巴瘤化疗患者癌因性疲乏的影响因素分析 及有氧运动的干预效果研究.

Objective: To analyze the influencing factors of cancer-related fatigue (CRF) in patients with non Hodgkin lymphoma (NHL) chemotherapy, and to explore the intervention effect of aerobic exercise on CRF in patients with NHL chemotherapy. Methods: 142 cases of patients with NHL chemotherapy who were admitted to The First Affiliated Hospital of Air Force Military Medical University from March 2021 to April 2022 were selected, the self-made questionnaire was used to collect data from the research subjects, a total of 142 questionnaires were distributed, and 142 questionnaires were recovered, among which 138 were valid, the effective recovery rate was 97.18%. According to the occurrence of CRF, patients were divided into CRF group (n=109) and non-CRF group (n=29). Multivariate Logistic regression was used to analyze the influencing factors of patients with CRF after NHL chemotherapy. Patients with CRF after NHL chemotherapy were given aerobic exercise intervention, and the CRF, depression and anxiety degree of patients were compared before and after intervention. Results: The CRF status of 138 patients with NHL was investigated, 109 of them had occurrence of CRF, the incidence rate was 78.99%. Univariate analysis showed that the occurrence of CRF in patients with NHL chemotherapy were related to employment situation, tumor stage, chemotherapy cycle, social support degree, Hamilton Depression Scale (HAMD) score, Hamilton Anxiety Scale (HAMA) score (P<0.05). The results of multivariate Logistic regression analysis showed that tumor with stage IV, 3~4 cycles of chemotherapy cycle, high HAMD score and high HAMA score were risk factors for CRF in patients with NHL chemotherapy, and high social support degree was a protective factor (P<0.05). After intervention, the perceptual dimension, behavioral dimension, cognitive dimension, affective dimension, and total score in the CRF group were all decreased compared with those before intervention (P<0.05). After intervention, HAMA and HAMD scores in the CRF group were decreased compared with those before intervention(P<0.05). Conclusion: The occurrence of CRF in patients with NHL chemotherapy is affected by factors such as chemotherapy cycle, HAMD score, HAMA score, and and high social support degree. And adhere to aerobic exercise can reduce fatigue, relieve depression and anxiety status. [ABSTRACT FROM AUTHOR]