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In the context of population ageing, the number of elderly patients with dementia is increasing day by day. This disease seriously affects the quality of life of the elderly and causes huge burdens and pressures on families and society. At this stage, issues such as low level of attention at the national and social levels, weak ability of active screening and identification, high treatment and care costs, and fragmented social service system are prominent in the elderly dementia. It is imperative to actively explore the construction of a care system that covers the entire life cycle of dementia in the elderly, which is composed of multiple welfare subjects such as the government, community, family, market, and civil society organizations. Based on the practice of the full-cycle support project for elderly patients with dementia and their families in Beijing X Hospital, the research takes the theory of welfare pluralism as the framework, and constructs the implementation path and mechanism of the welfare pluralism care system for the elderly with dementia through action research. Based on the portrayal of the reality of the elderly with dementia, health social workers break through the shortcomings of the original medical social work service, such as the single service object, the confinement of the service place, the disconnection of the needs of patients with different disease cycles, and the poor effect of the resource link, etc., turn to the perspective of health social work to use the method of action research to try to break the situation from four directions: in the stage of early detection of dementia, we can clarify the responsibilities of service subjects and maximize service effectiveness; in the stage of early treatment of dementia, we can break down barriers between service subjects and realize the value of resources flow; in the stage of self-management of patients with dementia, we can mobilize the subjective initiative of service subjects to achieve positive transformation of target group; in the dementia friendly advocacy stage, we can respond to the internal needs of service subjects and achieve sustainable development of the care system.

A 38-year-old female presented with irregular menstruation and hirsutism that started at age of 16 and diagnosed with polycystic ovary syndrome at age of 29 with elevated testosterone. When treated with ethinestradiol cyproterone tablets, her menstruation returned to normal and androgen levels was not changed. At age of 38 she was referred to the hospital with infertility, a diagnosis of nonclassical 21-hydroxylase deficiency was confirmed using 17-hydroxyprogesterone, dehydroepiandrosterone-sulfate, a cosyntropin-stimulation test and genetic test. This case suggested that nonclassical congenital adrenal hyperplasia should be considered when a patient is presented with oligomenorrhea, hirsutism with hyperandrogenemia and infertility.

Background The problem of population aging is serious in China, and chronic diseases comorbidity is becoming more and more common. Objective Based on the health ecology model, to systematically understand the main influencing factors of chronic disease comorbidity among the elderly in China, and to provide scientific reference for the prevention and control of chronic disease comorbidity among the elderly in China. Methods Based on the follow-up data of China Health and Retirement Longitudinal Study (CHARLS) 2018, a total of 10 779 samples aged ≥60 years were selected in March 2021. After excluding the samples with missing data and unqualified data, a total of 7 354 samples was included in this study. With the occurrence of chronic comorbidities (having ≥2 chronic conditions) as the dependent variable and the inclusion of independent variables according to the 5 dimensions of the health ecology model, a multivariate Logistic regression model was used to analyze the influencing factors of chronic disease comorbidity in the elderly. Results Among the elderly≥60 years old in China, the comorbidity rate of chronic diseases was 65.16% (4 792/7 354) , with 32.16% (1 541/4 792) patients suffered from two kinds of chronic diseases, and the diseases with the largest combination of two comorbidities were hypertension with arthritis or rheumatism〔16.42% (253/1 541) 〕. The results of the multivariate Logistic analysis showed that for the risk of comorbidities of chronic diseases in the elderly, females were higher than that in males〔OR (95%CI) =1.371 (1.177, 1.596) 〕, those over 70 years old were higher than those aged 60-70 years old〔OR (95%CI) =1.189 (1.061, 1.333) 〕, those who slept for 6-8 hours or more than 8 hours at night were lower than those who slept for less than 6 hours at night〔OR (95%CI) =0.759 (0.678, 0.850) , OR (95%CI) =0.686 (0.572, 0.821) 〕, those who took nap time of 0.5-1.0 h and over 1.0 h were higher than those of less than 0.5 h 〔OR (95%CI) =1.238 (1.102, 1.391) , OR (95%CI) =1.219 (1.604, 1.396) 〕, those who felt general and less satisfied with their health were higher than those who were very satisfied〔OR (95%CI) =1.755 (1.537, 2.004) , OR (95%CI) =5.890 (4.930, 7.037) 〕, those who registered in urban areas were higher than those in the rural areas〔OR (95%CI) =1.167 (1.036, 1.315) 〕, those living in the central and western regions were higher than those in the eastern region〔OR (95%CI) =1.311 (1.158, 1.483) , OR (95%CI) =1.491 (1.315, 1.692) 〕, those who were working were lower than those who had worked〔OR (95%CI) =0.768 (0.680, 0.866) 〕, and those with annual income > 50 000 per capita were higher than that of less than 20 000 yuan〔OR (95%CI) =1.413 (1.009, 1.978) 〕. Conclusion The incidence of chronic diseases comorbidity is higher in the elderly in China. The influencing factors of comorbidity of chronic diseases are multi-level and multi-dimensional. There are complex relationships between different influencing factors, which suggest strengthening multi-dimensional intervention and management of chronic diseases from individual to environment, so as to improve the health level of the population.

Polyester-ether glycol was synthesized with poly(polyol adipate) as starting agent, epoxy alkane as the polymerization monomer, and alkali metal as catalyst. The effects of catalyst dosage on the polymerization was discussed, and its structure was characterized by FTIR and GPC. The self-made polyester-ether glycol was used to prepare polyurethane high-resilience foam and polyurethane elastomer, and the effects of polyester-ether glycol on their mechanical properties were studied. The results showed that the optimum catalyst concentration was 0.6%. When polyester-ether glycol was applied to polyurethane high resilience foam with the addition amount of 15%, it had a significant effect on improving the mechanical properties of the products. Compared with traditional propylene glycol polyether, polyurethane synthesized with polyester-ether glycol had significant advantages in mechanical properties. [ABSTRACT FROM AUTHOR]

Smart contracts running on the blockchain platform completethe establishment and automatic execution of a greements between different participants,and also manage a large number of digital assets.The frequent exposure of smart contract loopholes has caused incalculable economic losses.Fuzzing is an effective dynamic vulnerability detection technique that has been applied to smart contract security research.This paper analyzes the problem of insufficient summarization of smart contract fuzzing in existing review work,and proposes a basic framework for smart contract fuzzing.Taking Ethereum smart contracts as an example,which are currently the most widely studied in smart contract security,the account mechanism and transaction structure closely related to smart contracts are introduced,and the characteristics of smart contracts that are different from traditional programs are summarized.The vulnerabilities of smart contracts are expounded,and the vulnerabilities covered by these smart contract fuzzing techniques are compared.Furthermore,the input generation of the existing smart contract fuzzing technology is analyzed from the aspects of single transaction and transaction sequence.The input mutation is summarized from the functional level,transaction level and transaction sequence level.The use of test oracles for existing smart contract fuzzing techniques is briefly described.In addition,the corresponding technical evaluation indicators are also summarized.Finally,the problems faced by smart contract fuzzing are proposed,and the future research directions are prospected.

Therapeutic radiopharmaceuticals combine radionuclides with carriers. It uses radionuclide suitable radiation energy and range in the tissue, selectively concentrated irradiation of diseased tissue, while avoiding damage to normal tissue and achieving the desired therapeutic effect. It is mainly used for cancer treatment or relief of tumor-related symptoms. It is widely used in tumor diagnosis and treatment, myocardial imaging, early detection of neurodegenerative diseases and imaging diagnosis of inflammatory tissues. In recent years, with the rapid development of targeted ligands and the wide application of new medical nuclides, radiotherapeutic drugs have attracted more and more attention. At present, nuclides such as 153Sm, 89Sr, 223Ra, 90Y, 131I and 177Lu are commonly used to treat cancer, bone metastasis, liver cancer and thyroid cancer, and show exciting potential in treatment. The research on radiotherapeutic drugs is also increasing rapidly. The clinical application and development status of radiopharma in the market and in the research stage are briefly introduced, in order to provide reference for the research and development of radiopharma in China.

Objective To investigate factors related to hypertension and their importance degrees in Kazakhs,from Altay city, Xinjiang Uygur Autonomous Region, with different occupations (citizen, farmer, and nomad) for target hypertension prevention. Methods According to the proportions of three occupation populations, 1 668 Kazakhs aged 30 years or older were selected by random cluster sampling from 2012 to 2013, in Hongdun Town, Altay City, Xinjiang. Hypertension related factors were investigated. We used random forest model to explore the factors related to hypertension and their importance degrees in different occupational groups. Results 1 646 participants were included in this study. We ranked the importance of hypertension related factors by feature importance scores. The top five hypertension related factors were waist circumference,triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), body mass index (BMI), and age for citizen; age, LDL-C, total cholesterol (TC), TG, and waist circumference for farmer. Age, BMI, waist circumference, TC, and LDL-C for nomad (feature importance scores＞0.06). The prediction accuracy of random forest models of hypertension for citizen, farmer, and nomad were 0.82, 0.69, and 0.76, respectively. Conclusions In different occupational groups, obesity and blood lipids were related to hypertension in different degrees, so the target of hypertension prevention should be carried out for different occupational groups. With the process of urbanization, urban residents should be well informed to controlling central obesity.

GH4720Li superalloy has been widely employed in high-performance aero engines turbine disks and other rotating component due to the excellent high temperature strength, anti-fatigue, corrosion resistance and long-term structural stability. The mechanism of function and evolution rule of γ'phase in GH4720Li superalloy was summed up in this paper. The relationship between γ'phase and high-temperature properties and the interaction law of γ'phase and residual stress were analyzed. In addition, the research progress of the new superalloy which was designed on the basis of GH4720Li superalloy was summarized, the future application of partitioned cooling technology and dual-organization dual-performance disk preparation technology was prospected.

Objective To analyze the spatial distribution characteristics, efficiency, and influencing factors of pension institutions in Dongguan, so as to provide reference for optimizing the resource allocation of pension institutions in Dongguan. Methods The resource allocation data of pension institutions in Dongguan were obtained by questionnaire survey, and the spatial distribution characteristics and efficiency of pension institutions were analyzed and evaluated based on GIS and three-stage DEA model. Results There was a good spatial coupling between the resources of pension institutions in Dongguan and the elderly population over 60 years old; the lowest occupancy rate was 12.50%, the highest was 100.005%, and the phenomenon of "difficulty in finding a bed" and "half of the beds were vacant" coexisted. In the third stage, the average comprehensive efficiency decreased from 0.679 to 0.635, and environmental factors had a great influence on the efficiency of resource allocation in Dongguan. There were great differences in the efficiency of pension institutions in different areas. The comprehensive efficiency of urban areas was 0.784, which exceeded the average level of the whole city (0.635). The comprehensive efficiency of the eastern industrial park was only 0.439, which did not reach the average level of the whole city. The per capita regional GDP and the level of aging had a negative impact on efficiency. Conclusion It is suggested to rationally allocate the resources of pension institutions, optimize regional development planning, promote the upgrading of institutional pension services, improve the efficiency of resource allocation, and provide improved reference scheme for improving the service level of pension institutions in Dongguan. [ABSTRACT FROM AUTHOR]

Through literature research, the unplugging mechanism of various wellbore unplugging fluids was analyzed, and the application progress, advantages and disadvantages of various types of commonly used wellbore deplugging fluids were summarized. The research progress of new deplugging working fluids such as organic deplugging working fluid, organic slow-release microlactic acid deplugging working solution and composite deplugging working fluid was introduced. The problems existing in the preparation and practical application of plugging fluids were analyzed, and the development trend of unplugging liquids in the future was proposed. [ABSTRACT FROM AUTHOR]

CCK as brain-gut peptide, binds to its receptor (CCKR) and participates in physiological processes such as feeding and digestion in animals. In order to study the function of CCKs and CCKRs in largemouth bass (Micropterus salmoides) in feeding activities, the coding sequences of CCK1, CCK2, CCK1R and CCK2R were cloned in this study. Their lengths were 414, 387, 1368 and 1359 bp, and their encodes were 137, 128, 455 and 452 amino acids, respectively. Fluorescence quantitative results showed that both CCK1 and CCK2 were highly expressed in brain, followed by intestinal, while CCK1R and CCK2R were highly expressed in gallbladder and brain, respectively. Within 24h after ingestion, the relative expressions of CCK1, CCK2, CCK1R and CCK2R increased first and then decreased. The relative expression of CCK1, CCK1R and CCK2R reached the highest value at 3h after ingestion, while the relative expression of CCK2 was at 12h after ingestion. The relative expression reached the highest value (P<0.05). During fasting, the relative expression of CCK1, CCK1R and CCK2R was significantly increased on the 14th day of fasting (P<0.05). The relative expression trends of CCK1, CCK1R and CCK2R after refeeding were similar to those after meals, showing a trend of first increasing and then decreasing. However, there was no significant change in the relative expression of CCK2 during fasting and refeeding. In conclusion, the results of this study indicated that CCK1 can be combined with CCK1R and CCK2R to act as a satiety signal factor to regulate physiological processes such as feeding and digestion of largemouth bass by suppressing appetite; CCK2 may act as a short-term appetite factor to regulate feeding. Activity. The results of this study can provide a theoretical basis for the regulation of feeding activities of largemouth bass. [ABSTRACT FROM AUTHOR]

In order to construct evaluation system of different waxy maize varieties during germination for low temperature tolerance, 48 waxy maize varieties were used as test materials to measure 10 indicators on germination and growth under low temperature stress. And the low temperature tolerances of waxy maize varieties were comprehensively evaluated by principal component analysis, membership function method, cluster analysis and regression analysis. The results showed that 10 measurement indexes were transformed into 2 independent comprehensive indexes by principal component analysis, including root growth factor and seed germination factor. The comprehensive score model of low temperature tolerance of waxy maize was established, Y=0.647 7Y1+ 0.144 2Y2, where Y1 and Y2 were scores of the two principal components, respectively. Y1 included relative root dry weight, relative root surface area, relative root volume, and relative root length, which could reflect the state of root growth of waxy maize under low temperature stress; and Y2 included relative seedling dry weight, relative germination rate, relative vitality index, and relative germination potential, which could reflect the germination of waxy maize under low temperature stress. The 48 waxy maize varieties were ranked by affiliation function method for low temperature tolerance, and the five varieties with the strong low temperature resistance were screened, including 'Runcainuo 686' 'Jingpo 82' 'Runnuo 175' 'Runnuo 605' and 'Tianguinuo 932'. The cluster analysis classified 48 waxy maize varieties into 4 groups. The regression analysis showed that the relative root dry weight, relative seedling length, relative germination potential, relative germination rate, relative seedling dry weight and relative root surface area could be used as important indicators for the evaluation of low-temperature tolerance of waxy maize. The comprehensive evaluation of multiple methods could effectively screen and classify waxy maize varieties with different low-temperature tolerances, which provided reference for the evaluation of waxy maize low-temperature tolerance and the screening of low-temperature tolerance germplasm resources. [ABSTRACT FROM AUTHOR]

PURPOSE: To investigate the effects of TiN and TiCN coating on corrosion resistance of pure titanium in the simulated oral environment. METHODS: The dental pure titanium commonly used in making removable denture was casted with 15 specimens, 10mmxl0mmxlmm in size. The specimens were randomly divided into group A, group B and group C. In the group B and group C, the specimens were coated with a thickness of 2.5p.m TiN and TiCN coating on surface by multi-arc physical vapor deposition, respectively. After microscopic energy spectrum analysis, microstructure and phase diffraction were examined by FESEM. Hardness and Young modulus of the various coating were determined by nanoindentation. The polarization curves of all specimens in artificial saliva were measured by PARSTAT'2273 electrochemical station. The data were analyzed with SPSS 17.0 software package for t test, one-way ANOVA and nonparametric test. RESULTS: Both the mierohardness and elastic modulus in the group B and group C were significantly superior to those in the group A (P<0.001). Meanwhile, both the microhardness and elastic modulus in the group C were significantly higher than those in the group B (P<0.01). Corrosion potential (Ecorr) was group A > group B > group C (P< 0.05). However, corrosion current density (Icorr) was significantly lower in the group A than in the group B, and in the group A than in the group C (P<0.01), while not significantly different between the B and group C (P>0.05).Breakdown potential (Ecorr) was group A

To meet the need of monitoring the crack damage located at bolt hole of metallic bolted-joint structure, a kind of damage monitoring smart washer with rosette eddy current sensor was proposed. The influences of washer electromagnetic properties on monitoring capability were analyzed based on constructed semi-analytic model, and experiment of 2A12-T4 aluminum alloy under constant loading spectrum was carried out to validate analysis results. Semi-analytic model results show that amplitude ratio variation of smart washer increases with washer relative permeability, while decreases with washer conductivity. The result of fatigue crack monitoring experiment of 2A12-T4 aluminum alloy under constant loading spectrum verifies the damage monitoring capability of smart washer with aluminum alloy and stainless steel materials. However, monitoring curve of smart washer with stainless steel material is smoother than that with aluminum alloy material, which indicates that the smart washer with steel stainless material has a better monitoring capability. The first channel of smart washer is capable of monitoring on accumulated damage and the other three channels are capable of quantitative monitoring on fatigue crack, with monitoring precision of 1 mm. [ABSTRACT FROM AUTHOR]

Usually, the design optimization only deals with individual component of the truck because of the complex coupling relation between the cab and frame of the truck under assembly environment. Focusing on the complete optimal problem, a new conception of static modal stiffness was introduced and the sensitivity of static modal stiffness was define& The method for computing static modal stiffness sensitivities was also developed. Above proposed method has been applied to analyze and design the truck's cab, where a finite element model for full vehicle was used and the cab was divided into 15 super-elements. It is concluded that the obtained static modal stiffness sensitivities could be used to improve the design of the cab. [ABSTRACT FROM AUTHOR]

In order to judge, the bearing safety of homogeneous ground that the heavy forcing plates acted on, static and dynamic outfield tests were carried out. According the static plate loading method, the outfield test that bearing plates simulating the static procedure of heavy forcing plates was performed. By the similarity criterion Π theorem, the pneumatic impact test of reduced proportional plate simulating the dynamic procedure of forcing plate was completed. Based on the outfield tests, the paper studied the S - t curves that express the variety of settlement with time, the P - S/D curves that express the soil settlement correlative relation among bearing plates with different sizes under the corresponding load, the P - S curves under static and dynamic loads as well as the contrast between them. To the homogeneous soil ground in outfield tests, S - t curves indicate that the static load method is reasonable, and P - S/D curves appear a linear proportional relation in the limit load range. The settlement under dynamic load is much less than that under static load. The deformation stiffness under dynamic load is higher than that under static load. The settlement caused by instant dynamic impact can be ignored. [ABSTRACT FROM AUTHOR]

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Copyright of Journal of Food Safety & Quality is the property of Journal of Food Safety & Quality Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In order to study the changes of taste substances of Fugu bimaculatus during cold storage, a rapid method to detect the freshness of Fugu bimaculatus during cold storage (0 °C and 4 °C) was established. The results of total bacterial count (TVC) were used as the criterion of fish freshness, and the response value of electronic tongue sensor was used as the dependent variable. The partial least squares (PLSR) and multiple linear regression (MLR) methods were used to establish the TVC prediction model, which can be used to distinguish the freshness of Fugu bimaculatus in different cold storage periods, and the model was verified. The results showed that both PLSR and MLR models can predict the freshness of fish at different refrigeration periods, but the MLR model had a better fit. The training sets (Rc²) of the TVC prediction models for the 0 C and 4 C groups were 0.98 and 0.99, respectively, The coefficient of determination (Rv²) of the prediction set was 0.97 and 0.99, the root means square error (RMSEV) of the training set was 0.40 and 0.08, and the root mean square error (RMSEP) of the prediction is 0.44 and 0.08. External verification results showed that the accuracy of the model test set was 100%, and it had a good predictive ability. The above results showed that the electronic tongue technology could be used as a rapid detection method for the freshness of the Fugu bimaculatus in the cold storage process. Taken together, these results suggest that electronic tongue technology can be used as a rapid detection method for the freshness of the Fugu bimaculatus in the cold storage process. [ABSTRACT FROM AUTHOR]

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