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[Purpose/Significance] In the current context of economic globalization, innovation ecosystem has become an important driving force to promote enterprise innovation development in China, the article interprets the knowledge management standard ISO30401 released in 2018 and tries to provide ideas for the construction and optimization of the innovation ecosystem of Chinese enterprises. [Method/Process] This paper began with an interpretation of the new global standard for knowledge management, ISO30401, and took the enterprise knowledge management system as an entry point, attempting to introduce the new knowledge management system into the construction of China's innovation ecosystem in terms of the establishment of a knowledge management system, changing the form of knowledge organisation, clarifying leadership roles and responsibilities in enterprise knowledge management, technological and infrastructural innovation and promoting the formation of a knowledge management culture within the enterprise. [Result/Conclusion] Knowledge in the innovation ecosystem flows in a continuous cycle among innovation subjects, the establishment of the knowledge management system will help enterprises to form a systematic and standardized knowledge management ability, effectively use the knowledge cycle, obtain knowledge advantages and competitive advantages, and constantly enhance the innovation ability of enterprises.

Objective: To explore pharmaceutical care by clinical pharmacists in the individualized treatment with voriconazole, so as to provide reference for rational use of drugs. Methods: Through analysis of the treatment of 3 cases by voriconazole, the clinical thinking of clinical pharmacists involved in drug treatment was clearly elucidated, and the entry point of pharmaceutical care was analyzed. Results; Based on the results of therapeutic drug monitoring (TDM ), clinical pharmacists proposed proper adjustment in the voriconazole treatment profile, and as a result, clinical efficacy was improved, the rate of adverse drug reactions (ADRs) was reduced, and more importantly medication safety was well ensured. Conclusion; TDM is a powerful tool for active involvement of clinical pharmacists in the individualized treatment with voriconazole, and its proper application could improve clinical efficacy and drug safety. [ABSTRACT FROM AUTHOR]

Objective: To investigate the distribution and exposure levels of pesticides in raw water and drinking water in China, as well as to assess the potential health risks associated with long-term consumption., Methods: A total of 83 typical water plants were selected in key river basins in China to collected samples of the raw water, finished water, and tap water. The online-solid phase extraction coupled with liquid chromatography-tandem mass spectrometry method was used to determine 13 pesticides, including acetochlor, atrazine, dimethoate, malathion, carbofuran, dichlorvos, chlorpyrifos, parathion, trifluralin, isoprothiolane, simetryn, methyl parathion, and metalaxyl, as well as 6 environmental metabolites, including carbendazim, malaoxon, 3-hydroxycarbofuran, deethyl atrazine, deisopropyl atrazine and hydroxy atrazine. The carcinogenic and non-carcinogenic risks of these pesticides were assessed., Results: The concentrations of total amount of pesticides in the samples ranged from 0.1 ng/L to 1299.4 ng/L, with a median value of 64.7 ng/L. The detection rates of 5 pesticides or their metabolites exceeds 80%, namely acetochlor, atrazine, hydroxyl atrazine, deethyl atrazine, and metalaxyl. More than 6 pesticides or their metabolites were detected in 77.7% of the total 498 samples. The total concentration of pesticides during the wet season ranged from 1.1 ng/L to 1299.4 ng/L, with a median of 69.2 ng/L and a median average daily dose of 2.3 ng/(kg·d). The total concentration of pesticides in the dry season samples ranged from 0.1 ng/L to 543.5 ng/L, with a median of 60.2 ng/L and a median average daily dose of 2.0 ng/(kg·d). Among the 498 samples, the maximum carcinogenic risk of dichlorvos was 2.0×10~(-7), and the maximum carcinogenic risk of trifluralin was 1.1×10~(-10). The non-carcinogenic HI of 19 pesticides and metabolites pesticides was ≤6.0×10~(-3). Among them, the maximum HI of the middle route of the South to North Water Diversion Project, the lower reaches of the Yellow River, the eastern route of the South to North Water Diversion Project, the Liaohe River, and the Songhua River basin was 2.0×10~(-3)-6.0×10~(-3), while the HI of other basins was less than 1.0×10~(-3)., Conclusion: Different concentrations of pesticides have been detected in raw water, finished water, and tap water of key river basins in China, with the highest total concentration of detected reaching 1299.4 ng/L. The carcinogenic risk was lower than 10~(-6) and the non-carcinogenic hazard index of 19 pesticides was less than 1, and both below the acceptable level. Because of the universality and diverse occurrence of these pesticides in drinking water, long-term exposure to pesticides is still a concern.

In order to monitor the risk of pesticide pollutants in drinking water, an analytical method based on online-solid phase extraction coupled with ultra performance liquid chromatography-triple quadrupole mass spectrometry (online-SPE-UPLC-MS/MS) was established for the simultaneous rapid screening and determination of 107 pesticides and metabolites (organophosphorus, organic nitrogen, organic heterocycle, carbamate, amide, benzoyl urea, neonicotinoid, etc.) in raw water and drinking water. Different injection volumes (5, 10, and 15 mL) were compared. The detection response increased with an increase in the injection volume, but the matrix effect also became more pronounced. Under the premise of ensuring the sensitivity of the method and meeting the detection requirements, the injection volume was selected as 5 mL. Accordingly, the samples were filtered through a 0.22-μm hydrophilic polytetrafluoroethylene filter, and then, 5 mL samples were injected into the online-SPE system by the automatic sampler. After adsorption on an X Bridge C 18 online-SPE column, the samples were washed with pure water and eluted by gradient elution using acetonitrile and 0.1% formic acid aqueous solution as the mobile phases, with separation on an ACQUITY HSS T 3 column. The samples were detected by multiple reaction monitoring with electrospray ionization in positive and negative ion modes, and quantified by an external standard method. Using raw water and drinking water as the sample matrices, the accuracy and precision of the method were verified. The 107 pesticides and metabolites showed good linear relationships in different ranges with correlation coefficients ( r 2 )>0.995. The limits of detection (LODs, S/N =3) of the method were 0.03-1.5 ng/L, and the limits of quantification (LOQs, S/N =10) were 0.1-5.0 ng/L. The target pesticides were spiked at concentration levels of 1, 20, and 50 ng/L. The spiked recoveries of the 107 targets in raw water and drinking water samples were 60.6%-119.8% and 61.2%-119.0%, respectively. The corresponding relative standard deviations (RSDs, n =6) were 0.3%-18.6% and 0.4%-17.1%. The pesticide residues in raw water and drinking water were determined by this method. Amide herbicides, triazine herbicides, triazole insecticides, carbamate insecticides, and neonicotinoid insecticides had high detection rates. The detected concentrations ranged from 0.1 to 97.1 ng/L in raw water and from 0.1 to 93.6 ng/L in drinking water. The sample consumption of online-SPE method was lower than that in the traditional off-line SPE methods, which greatly improved the convenience of sample collection, storage, and transportation. The samples only need to be filtered before injection and analysis. The method is simple to operate and shows good reproducibility. With this online-SPE method, only 23 min were required from online enrichment to detection completion. The developed method has the advantages of high analytical speed and high sensitivity. The method is suitable for the trace analysis and determination of 107 typical pesticides in raw water and drinking water, which effectively improves the detection efficiency of pesticides in water and has high potential for practical application. It can extend technical support for the pollution-level analysis of typical pesticides and metabolites in drinking water and provide an objective basis for human health risk assessment.

Objective: To develop a method for the determination of 11 perfluorinated compounds(PFCs) in drinking water by solid phase extraction-ultra performance liquid chromatography tandem mass spectrometry(UPLC-MS/MS)., Methods: The target analytes in water samples were concentrated and purified by Oasis WAX SPE column and eluted with 5 mL methanol and 7 mL 0. 1% ammonia-methanol solution. The eluent was blown to near dryness under a nitrogen gas, diluting with methanol water solution(3∶7, V/V) to 1 mL for analysis by UPLC-MS/MS., Results: There were good liner relationship in the range of 0. 5-50 μg/L. The detection limit and the limit of quantitation were 0. 03-0. 7 ng/L and 0. 5-3. 0 ng/L, respectively. The recoveries of 11 PFCs at three different spiked concentrations were 90. 0%-122. 3%, 87. 1%-130. 0% and 80. 0%-113. 7%, respectively, and the relative standard deviation were 1. 95%-8. 59%, 1. 27%-9. 08% and 2. 17%-10. 51%(n=6), respectively., Conclusion: This method has wide linear range, low detection limit and limit of quantitation, applicable for simultaneous analysis and monitorting of 11 PFCs in drinking water.

An analytical method for the determination of carbamate pesticides (carbofuran, carbaryl, isoprocarb and diethofencarb) in reservoir water using hollow fiber-based liquid phase microextraction (HF-LPME) coupled with high performance liquid chromatography (HPLC) was developed. Some main experimental parameters that affect the extraction efficiency were optimized. Toluene was selected as both the extraction solvent and the impregnation solvent. The extraction was carried out at room temperature (20 degrees C ) in a 5 mL Teflon-lined septum cap vial filled with 4.5 mL of sample solution at a stirring rate of 720 r/min for 20 min. The extract was dried under nitrogen stream at room temperature. The dried residue was then dissolved in the mobile phase for HPLC analysis. The separation was carried out on a Baseline C18 column (4.6 mm x 250 mm, 5.0 microm) with methanol-water (60:40, v/v) as the mobile phase at a flow rate of 1.0 mL/min. The detection for carbofuran, carbaryl, isoprocarb and diethofencarb was selected at 200, 223, 200 and 208 nm, respectively. The average enrichment factors for the four analytes were greater than 45. The linear range for the quantification of the four analytes was 10 - 100 microg/L (r > 0.99). The limits of detection (LODs) were 5, 1, 5 and 3 microg/L (S/N = 3) for carbofuran, carbaryl, isoprocarb and diethofencarb, respectively. Good recoveries (82.0% - 102.2%) and good reproducibilities (2.0% - 6.2%, n = 6) were achieved.