Objective To study the efficacy of fibrinogen (FIB) concentrate combined with carboprost tromethamine in the early treatment of postpartum hemorrhage (PPH). Methods Patients with PHH admit-ted to the hospital from January 2018 to May 2021 were selected as study subjects and divided into the experi-mental group (32 cases) and the control group (32 cases) by randomized number tables. The experimental group was treated with (0. 2-0. 3g) / 10 kg FIB concentrate combined with 250 jig carboprost tromethamine, and the control group was treated with 250 pg carboprost tromethamine. The clinical efficacy and blood loss, coagulation indexes [activated partial thrombin time (APTT), plasma thrombin time (TT),prothrombin time (PT),FIB,and D-dimer (D-D)] before and after medication of the two groups were compared. Results The total effective rate of experimental group was 90. 62% (29/32),which was significantly higher than that of the control group 68.75% (22/32),and the difference was statistically significant (P<0. 05). There was no statistical significance in the blood loss between the two groups at 15 min postpartum (P>0. 05), and the blood loss in the experimental group was significantly less than that in the control group at two hours after drug treatment and 24 hours after postpartum, with statistical significance (P<0.05). There was no statistical significance in APTT,TT,PT,FIB and D-D values between the two groups before delivery ( P >0. 05). APTT, TT,PT and D-D values of the experimental group were significantly lower than those of the control group after delivery, while FIB value was significantly less than that in the control group at two hours after drug treatment and 24 hours after postpartum, with statistical significance (P<0.05). There was no statistical significance in APTT, TT,PT, FIB and D-D values between the two groups before delivery (P>0.05). APTT, TT,PT and D-D values of the experimental group were significantly lower than those of the control group after delivery, while FIB value was significantly higher than that of the control group, with statistical significance (P<0.05). Conclusion The combination of FIB concentrate and carboprost tromethamine in the treatment of PPH has better effect, less blood loss and better coagulation function, which is worthy of further clinical research and promotion. [ABSTRACT FROM AUTHOR]